<?xml version="1.0" encoding="UTF-8"?>
<uniprot xmlns="http://uniprot.org/uniprot"
 xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
 xsi:schemaLocation="http://uniprot.org/uniprot http://www.uniprot.org/docs/uniprot.xsd">
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYG8</accession>
    <name>J7LYG8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3654"/>
    <dbReference type="EnsemblBacteria" id="AFR42833">
        <property type="protein sequence ID" value="AFR42833"/>
        <property type="gene ID" value="Gmet_3654"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3654"/>
    <dbReference type="HOGENOM" id="CLU_2464640_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="88" mass="9828" checksum="1F5F57771DC741F6" modified="2012-10-31" version="1">MKCPHCSCSSQREITLGAYGASRSYLECEHCGNLWSPYQEHFYMNCPKCAKSPGGDIFLTGDDKLPTILCHDCGMPWVVLDTKKRLPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PQ1</accession>
    <name>Q39PQ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_A3568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514727.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3568"/>
    <dbReference type="EnsemblBacteria" id="ABB33773">
        <property type="protein sequence ID" value="ABB33773"/>
        <property type="gene ID" value="Gmet_A3568"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3568"/>
    <dbReference type="eggNOG" id="ENOG5032U5F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2129858_0_0_7"/>
    <dbReference type="OMA" id="WSVVIRY"/>
    <dbReference type="OrthoDB" id="1808576at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="113" mass="12515" checksum="ABA5C906E5C46A59" modified="2005-11-22" version="1">MANTETIDYAILQRLIEAGAIRGAEVIGQPGGWSVIFKYGMTERALGVRGGKVRIFRKIETLVAYLRELGIVQFTVNAANYDPTTTIRPGRPDTSERMKRAFAVAQDIKEGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q61</accession>
    <name>Q39Q61_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilB/PulE/GspE family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514208.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3401"/>
    <dbReference type="EnsemblBacteria" id="ABB33613">
        <property type="protein sequence ID" value="ABB33613"/>
        <property type="gene ID" value="Gmet_3401"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3401"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_2_0_7"/>
    <dbReference type="OMA" id="PYVRLKK"/>
    <dbReference type="OrthoDB" id="443928at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SSE_N" evidence="1">
        <location>
            <begin position="43"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="540" mass="57638" checksum="DC6F5ED3DBCE3335" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q83</accession>
    <name>Q39Q83_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Endolytic peptidoglycan transglycosylase RlpA</fullName>
            <ecNumber evidence="3">4.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rlpA</name>
        <name evidence="6" type="ordered locus">Gmet_3379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the RlpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512605.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3379"/>
    <dbReference type="EnsemblBacteria" id="ABB33591">
        <property type="protein sequence ID" value="ABB33591"/>
        <property type="gene ID" value="Gmet_3379"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3379"/>
    <dbReference type="eggNOG" id="COG0797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042923_7_1_7"/>
    <dbReference type="OMA" id="THGRIID"/>
    <dbReference type="OrthoDB" id="2027419at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02071">
        <property type="entry name" value="RlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034718">
        <property type="entry name" value="RlpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009009">
        <property type="entry name" value="RlpA-like_DPBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012997">
        <property type="entry name" value="RplA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03330">
        <property type="entry name" value="DPBB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="SSF50685"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00413">
        <property type="entry name" value="rlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009992535" description="Endolytic peptidoglycan transglycosylase RlpA" evidence="3">
        <location>
            <begin position="31"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DPBB_1" evidence="5">
        <location>
            <begin position="55"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="16360" checksum="1F5D4757D6C7BFA8" modified="2005-11-22" version="1" precursor="true">MVSVYRKGRLATLIILCQAFFQIQTLSLQADEIAAKATTEGVASATTKADEGVIGTASYYAKRYNGRRMTSGKRYNPQELTAAHPTLPLGTKVKVVNVANNREVTVTITDRCRKKVSHFIDLSRAAARKLGFLGRGTTVVRIITLDEAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QH2</accession>
    <name>Q39QH2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Isovaleryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_3289</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512512.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3289"/>
    <dbReference type="EnsemblBacteria" id="ABB33502">
        <property type="protein sequence ID" value="ABB33502"/>
        <property type="gene ID" value="Gmet_3289"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3289"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_1_7"/>
    <dbReference type="OMA" id="CFITNSG"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901565">
        <property type="term" value="P:organonitrogen compound catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd01156">
        <property type="entry name" value="IVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034183">
        <property type="entry name" value="IVD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="11">
        <location>
            <begin position="15"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="10">
        <location>
            <begin position="128"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="9">
        <location>
            <begin position="235"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="246"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="369"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="162"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="342"/>
            <end position="346"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="371"/>
            <end position="373"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR634183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="390" mass="42676" checksum="778586271F2C1B4B" modified="2005-11-22" version="1">MKAYPTLNFDLGETSSILRETVKEFAAKEITPRATDIDRDNHFPMDLWPKMGQLGLLGVTVSEEYGGAAMGYLEHVIAMEELSRASASVGLAYGAHSNLCVNQIFRNGNESQRRKYLPKLISGEHVGALAMSEPGAGSDVVSMRLRADKKGDRFILNGNKMWITNGPHADTLVVYAKTDMNAGPRGITAFLIEKGFKGFSTAQKLDKLGMRGSDTCELVFENCEVPEENILGGVGRGVNVLMSGLDYERAVLASGPLGIMQACMDVVVPYLHERKQFDQPIGQFQLMQGKIADMYTTLNASRAYVYAVANACTRGETSRKDCAGAILYAAEKATWMALEAIQCLGGNGYINEYPTGRLLRDAKLYEIGAGTSEIRRMLIGRELFEETVHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QH7</accession>
    <name>Q39QH7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366174.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3284"/>
    <dbReference type="EnsemblBacteria" id="ABB33497">
        <property type="protein sequence ID" value="ABB33497"/>
        <property type="gene ID" value="Gmet_3284"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3284"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_7"/>
    <dbReference type="OMA" id="FQEACWA"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="272" mass="29679" checksum="7DDF52BF25D22EE7" modified="2005-11-22" version="1">MTMAMPQLTDATLELSERVALLTFCRNDVRNALTGTTLVDDILATLDWANRTPEVSVLVMTGEGAAFSSGGNVKEMRDRQGIFSGSSMTIQDQYRRGIQRIPLAMERAEIPLIASVNGPAIGAGFDLACMCDIRIGSSEAVVGETFINLGIIPGDGGAWFLQRLVGYQRAAELTFTGRLVDATEALKLGIFLEVTEPTQLIPRSHELASRIASKSPHAVRMTKRLMKHAQRGDLADFLDLCACFQGMAHHTDDHREAINAFLEKRAPVYAGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-08-10" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QP7</accession>
    <name>LON_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lon protease</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lon</name>
        <name type="ordered locus">Gmet_3214</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="1">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512652.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QP7"/>
    <dbReference type="SMR" id="Q39QP7"/>
    <dbReference type="STRING" id="269799.Gmet_3214"/>
    <dbReference type="MEROPS" id="S16.001"/>
    <dbReference type="EnsemblBacteria" id="ABB33427">
        <property type="protein sequence ID" value="ABB33427"/>
        <property type="gene ID" value="Gmet_3214"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3214"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_7"/>
    <dbReference type="OMA" id="KKMNPVM"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000396571" description="Lon protease">
        <location>
            <begin position="1"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="3">
        <location>
            <begin position="22"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="2">
        <location>
            <begin position="605"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="788"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="692"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="735"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="369"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="823" mass="91223" checksum="92D55831BA3458FF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QQ6</accession>
    <name>RIMO_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein S12 methylthiotransferase RimO</fullName>
            <shortName evidence="1">S12 MTTase</shortName>
            <shortName evidence="1">S12 methylthiotransferase</shortName>
            <ecNumber evidence="1">2.8.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal protein S12 (aspartate-C(3))-methylthiotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosome maturation factor RimO</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimO</name>
        <name type="ordered locus">Gmet_3205</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-SH + AH2 + L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 2 S-adenosyl-L-methionine = 3-methylsulfanyl-L-aspartate(89)-[ribosomal protein uS12]-hydrogen + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37087"/>
            <dbReference type="Rhea" id="RHEA-COMP:10460"/>
            <dbReference type="Rhea" id="RHEA-COMP:10461"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:29961"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:73599"/>
            <dbReference type="EC" id="2.8.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthiotransferase family. RimO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512643.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QQ6"/>
    <dbReference type="SMR" id="Q39QQ6"/>
    <dbReference type="STRING" id="269799.Gmet_3205"/>
    <dbReference type="EnsemblBacteria" id="ABB33418">
        <property type="protein sequence ID" value="ABB33418"/>
        <property type="gene ID" value="Gmet_3205"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3205"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_0_1_7"/>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103039">
        <property type="term" value="F:protein methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018339">
        <property type="term" value="P:peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01865">
        <property type="entry name" value="MTTase_RimO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005840">
        <property type="entry name" value="Ribosomal_S12_MeSTrfase_RimO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041582">
        <property type="entry name" value="RimO_TRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43837">
        <property type="entry name" value="PTHR43837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18693">
        <property type="entry name" value="TRAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00274">
        <property type="entry name" value="ribosomal_protein_S12_methylth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01125">
        <property type="entry name" value="TIGR01125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000374845" description="Ribosomal protein S12 methylthiotransferase RimO">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="1">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="143"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="376"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="445" mass="50210" checksum="D3765733199B4C98" modified="2005-11-22" version="1">MKEKVSMVSLGCPKNLVDAEVMLGCLAKDQYEITTDEHEADIIIVNTCSFIGDAKKESIDTILDLADRKHDGRCKLLVVTGCLPQRYQEELATELPEVDIFVGTADYPRIAEIIAEKRGVAEQLRYISDPNYIFDESLPRLKSSPAYTAYLKIAEGCSNCCSYCVIPSLRGALRSRPLDNLLMEARTLVATGTREINLIAQDITAWGRDLPGSPTLEELVRELAKIVGLRWIRLLYAYPDGITDGLIEIIKTEPKVCKYLDIPIQHISDPVLKRMNRRSTEPQIRALIAKIRAEIPEIALRTSLIVGFPGETEEDFRTLLHYVEETQFDRLGVFCYSREEGTPAAGMEDQVSERVKRDRYKKLMKVQARLSFKRNRRLIDTEEEVIVEGYSDETDLLLKGRSSRQAPDIDGQVYITAGNANVGDIVRLRITDSSDYDLIGEIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QT1</accession>
    <name>Q39QT1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513897.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3180"/>
    <dbReference type="EnsemblBacteria" id="ABB33393">
        <property type="protein sequence ID" value="ABB33393"/>
        <property type="gene ID" value="Gmet_3180"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3180"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_504098_0_0_7"/>
    <dbReference type="OMA" id="CPRFKND"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="330"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="540" mass="61215" checksum="097B3C5513353ED1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QW3</accession>
    <name>Q39QW3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33361.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513864.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3148"/>
    <dbReference type="EnsemblBacteria" id="ABB33361">
        <property type="protein sequence ID" value="ABB33361"/>
        <property type="gene ID" value="Gmet_3148"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3148"/>
    <dbReference type="eggNOG" id="ENOG5033I4X">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200299_0_0_7"/>
    <dbReference type="OMA" id="NNREHAK"/>
    <dbReference type="OrthoDB" id="2082274at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223002" evidence="1">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33361.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="73" mass="8162" checksum="6BF69A531872D055" modified="2012-10-31" version="2">MGRGVVVAFFFCMLALAACSGKGAQELFETAQFEEKQHNLEHARKLYEEIIAKHPQSELAAKAKERLNAMPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QY5</accession>
    <name>Q39QY5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514300.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3125"/>
    <dbReference type="EnsemblBacteria" id="ABB33339">
        <property type="protein sequence ID" value="ABB33339"/>
        <property type="gene ID" value="Gmet_3125"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3125"/>
    <dbReference type="eggNOG" id="COG3439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126998_1_1_7"/>
    <dbReference type="OMA" id="LPCKIVV"/>
    <dbReference type="OrthoDB" id="1819840at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016796">
        <property type="entry name" value="UCP021774"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03625">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021774">
        <property type="entry name" value="UCP021774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="SSF103247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF302" evidence="1">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="132" mass="14454" checksum="B6547865AA568595" modified="2005-11-22" version="1">MELTTSYAFGKTVGMGYVEAVARVREELGKEGFGVLTEIDVTEKFREKLGRDFRDYIILGACNPAMAWEAFQRELNIGTLLPCNVCVYTDDDGKTVVMVMDPVAALGVIGNAELTEVAAAVRQKMERVLAAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R83</accession>
    <name>COAE_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dephospho-CoA kinase</fullName>
            <ecNumber evidence="1">2.7.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephosphocoenzyme A kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaE</name>
        <name type="ordered locus">Gmet_3026</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3'-dephospho-CoA + ATP = ADP + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18245"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoaE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514340.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39R83"/>
    <dbReference type="SMR" id="Q39R83"/>
    <dbReference type="STRING" id="269799.Gmet_3026"/>
    <dbReference type="EnsemblBacteria" id="ABB33241">
        <property type="protein sequence ID" value="ABB33241"/>
        <property type="gene ID" value="Gmet_3026"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3026"/>
    <dbReference type="eggNOG" id="COG0237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057180_0_0_7"/>
    <dbReference type="OMA" id="VRWEMYR"/>
    <dbReference type="OrthoDB" id="1515383at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00356"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00376">
        <property type="entry name" value="Dephospho_CoA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00152">
        <property type="entry name" value="TIGR00152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000243291" description="Dephospho-CoA kinase">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DPCK" evidence="1">
        <location>
            <begin position="3"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00376"/>
        </source>
    </evidence>
    <sequence length="201" mass="21828" checksum="27780D79AE7A7231" modified="2005-11-22" version="1">MLVIGLTGGIASGKSTVARILERLGATIIDADLLAREAVLPGTPAHRAIVAAFGTEILLPDATIDRKALGRIVFANPDARRRLEAITHPAIARLSQARLAEARRSDAPAVFYVAPLLIEAGAADRVDDIWVVYADRETQLARLTERDGIGRGEAEQRLAAQMPMDEKASYGSAVIDNRGTSEETERQVVALWKERIEKNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RA0</accession>
    <name>Q39RA0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514322.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3009"/>
    <dbReference type="EnsemblBacteria" id="ABB33224">
        <property type="protein sequence ID" value="ABB33224"/>
        <property type="gene ID" value="Gmet_3009"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3009"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064298_0_0_7"/>
    <dbReference type="OMA" id="RINMFLR"/>
    <dbReference type="OrthoDB" id="1238363at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014127">
        <property type="entry name" value="CHP02757"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09674">
        <property type="entry name" value="DUF2400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02757">
        <property type="entry name" value="TIGR02757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="285" mass="31549" checksum="1EE181106CBB4FD3" modified="2005-11-22" version="1">MDFKTVLDNLYAARSTRHLANDPLSFCHRFVAPEDREIAGLVASCLAYGNVKIILRNLETVFAALGPSPRRFVERFELEEGLRLFAGFKHRFNDGRDLCALLLAARTMIEEADTIGDFFLGCHDPHAEDITSSLTEFSAAILAFDYAPVFGSDAIPADSYFPFFFPSPASGSACKRLCMYLRWMVRPADGIDLGVWKGVSPGQLVIPVDAHIRRICRSLGFTKRKQADWRMAREITAALRQLDPADPVKYDFPLCHLGISEGCDGTVQPLCRQCPVVELCGAGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RB2</accession>
    <name>Q39RB2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514488.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2997"/>
    <dbReference type="EnsemblBacteria" id="ABB33212">
        <property type="protein sequence ID" value="ABB33212"/>
        <property type="gene ID" value="Gmet_2997"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2997"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124904_1_1_7"/>
    <dbReference type="OrthoDB" id="1775689at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223184" evidence="1">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="133" mass="14537" checksum="89B26AE3F7385067" modified="2005-11-22" version="1">MMARCLVLFTVALLAASLAGSARAEIFVVSNSGTSLDSDEIFDVFLGGKQFSGDTKLVPVDNAAAHEEFLAKVLRMSHSRYTALWIRKSFRDGTRQPPVKAGDTETIEFVRKTPGAVGYVRVLPKGLKVIRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RE1</accession>
    <name>Q39RE1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512901.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2968"/>
    <dbReference type="EnsemblBacteria" id="ABB33183">
        <property type="protein sequence ID" value="ABB33183"/>
        <property type="gene ID" value="Gmet_2968"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2968"/>
    <dbReference type="eggNOG" id="COG4190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130787_1_0_7"/>
    <dbReference type="OMA" id="FPYDAVH"/>
    <dbReference type="OrthoDB" id="1887301at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="113" mass="12828" checksum="0F26C37302559BA7" modified="2005-11-22" version="1">MRTVTLEIASREKINRRFLRAFDDESQGAFISFESPELLFKVISGRRWDLLKVMTGAGPMTIREAARRMKRDVKAVHADVHVLLKAGIVQKTDKGLIVFPFDAVHVDFMLKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RF2</accession>
    <name>Q39RF2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2955</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2955"/>
    <dbReference type="EnsemblBacteria" id="ABB33172">
        <property type="protein sequence ID" value="ABB33172"/>
        <property type="gene ID" value="Gmet_2955"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2955"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056435_5_1_7"/>
    <dbReference type="OMA" id="EGRNAIW"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="39"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="201" mass="22177" checksum="59C31E0313B7CAB9" modified="2005-11-22" version="1">MSDRKTMWDERYDTTDFVYGREPNAFLAEVVQQIPPGDVLCLAEGEGRNAVFLAKQGHRVLAVDSSAVGLVKAARLAEESGVRIETETADLAEFAIEPVCWDAIVSIFCHVPPQVRRALHRKVVEGLRPGGLFILEAYTPAQLKLRTGGPPTEEVMMTLAGLREELAGLEFLQAREIEREVVEGRFHTGRGAVVQVVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RF6</accession>
    <name>Q39RF6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2951"/>
    <dbReference type="EnsemblBacteria" id="ABB33168">
        <property type="protein sequence ID" value="ABB33168"/>
        <property type="gene ID" value="Gmet_2951"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2951"/>
    <dbReference type="eggNOG" id="COG5587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036742_2_1_7"/>
    <dbReference type="OMA" id="YKTHQGA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012808">
        <property type="entry name" value="CHP02453"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015996">
        <property type="entry name" value="UCP028451"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36452">
        <property type="entry name" value="PTHR36452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09365">
        <property type="entry name" value="DUF2461"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028451">
        <property type="entry name" value="UCP028451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02453">
        <property type="entry name" value="TIGR02453"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="239" mass="28190" checksum="9838F5D80C502D34" modified="2005-11-22" version="1">MGRHRLVKEKAMDDRPRGTFTGFSPQTVTFLSSLAGNNTKAWFETHRGDYEERLLEPMKALVAELSDFMLSIDQDFVTVPGRAISRIHRDTRFSRDKSPYKTTLWITFKRQITEWRDAPCYFFELTACSYRFGMGFYSASKGTMDRLRETIERKPAQFRETVAFLGGQKRFVLEGEVYRRPLRHDLPEDLQEWHRRKNLYLVCNRQPDNALFSRKLVDDLRTGFGMLAPFYDYLLKARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RF8</accession>
    <name>Q39RF8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein CstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cstA-1</name>
        <name evidence="11" type="ordered locus">Gmet_2948</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512884.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2948"/>
    <dbReference type="EnsemblBacteria" id="ABB33166">
        <property type="protein sequence ID" value="ABB33166"/>
        <property type="gene ID" value="Gmet_2948"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2948"/>
    <dbReference type="eggNOG" id="COG1966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010531_2_0_7"/>
    <dbReference type="OMA" id="MLAESFV"/>
    <dbReference type="OrthoDB" id="457782at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="553"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="31"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="10">
        <location>
            <begin position="451"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="642" mass="68261" checksum="2F7C47A0671B5439" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RJ6</accession>
    <name>THIC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphomethylpyrimidine synthase</fullName>
            <ecNumber evidence="1">4.1.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hydroxymethylpyrimidine phosphate synthase</fullName>
            <shortName evidence="1">HMP-P synthase</shortName>
            <shortName evidence="1">HMP-phosphate synthase</shortName>
            <shortName evidence="1">HMPP synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thiamine biosynthesis protein ThiC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiC</name>
        <name evidence="2" type="synonym">thiC-1</name>
        <name type="ordered locus">Gmet_2910</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 5'-deoxyadenosine + CO + formate + 3 H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:24840"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512846.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RJ6"/>
    <dbReference type="SMR" id="Q39RJ6"/>
    <dbReference type="STRING" id="269799.Gmet_2910"/>
    <dbReference type="PRIDE" id="Q39RJ6"/>
    <dbReference type="EnsemblBacteria" id="ABB33128">
        <property type="protein sequence ID" value="ABB33128"/>
        <property type="gene ID" value="Gmet_2910"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2910"/>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013181_2_2_7"/>
    <dbReference type="OMA" id="TWELFRD"/>
    <dbReference type="OrthoDB" id="505395at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00089">
        <property type="entry name" value="ThiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037509">
        <property type="entry name" value="ThiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000242266" description="Phosphomethylpyrimidine synthase">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="188"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33128.1"/>
        </source>
    </evidence>
    <sequence length="436" mass="47004" checksum="0EC5702BC4CAB84C" modified="2005-11-22" version="1">MATTQLEYARQGIITDKMKEAALAEGVSPEFIREGIAAGTIIICHNIKHGNGRPLAVGKGLRTKVNANIGTSADDTDITKELEKARVAVRHGADAIMDLSTGGPVDEIRRAIIAETNACIGSVPLYQAALDAVRTKKKAIVDMTVDDIFEGIIKHAEDGVDFITVHCGVTRSTVERMKNEGRLMDVVSRGGAFTVEWMAYNNCENPLFEHFDRLLEITKAYDMTLSLGDGFRPGCLADATDRAQIHELIILGELTQRAQAAGVQVMIEGPGHVPLNQIEANILLQKRLCHGAPFYVLGPLVTDIAPGYDHITCAIGGAIAASAGADFLCYVTPSEHLRLPSVEDVREGVIASRIAAHAADIAKGVKGAMEKDIAMAKCRKKLDWEGQFNLSLDPEKAQRLRAESGVAEHGACTMCGEFCAYKVMDDAMEKQRAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RM7</accession>
    <name>Q39RM7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514610.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2879"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33097">
        <property type="protein sequence ID" value="ABB33097"/>
        <property type="gene ID" value="Gmet_2879"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2879"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_4_0_7"/>
    <dbReference type="OMA" id="FFCYCED"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="328" mass="35953" checksum="83D5505BA5E0E1BE" modified="2005-11-22" version="1">MTGLKPRVSVIVLTWNGKRYLPGCLGALAVQTFRDFEVILVDNGSEDGSGQYVREAFPWVRLVELPENLGFAEGNNRGLATAQGKLIVTLNNDTLAEPGFLAELVGAAERYPRAGMIAALLVNFYDPARIDAAGIAPGFDGLGYCLGHGEPVGAPWDTSREVFGPSAGAALYRREMIDEIGFFDAAFFAYAEDFDLAWRGRRAGWPCMTAPQAVVRHVHSATSGTESPFTIYHIHRNKWYVLLKDWPTRLLLRHLPRILMADLAALSVALLKGRGGAALRARWGVLAALPWLLVKRREDDGKRAPLPVEQLFARGLSLAALKRKLGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RQ1</accession>
    <name>Q39RQ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamin biosynthesis thiocarboxylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiF-1</name>
        <name evidence="2" type="ordered locus">Gmet_2855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514561.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2855"/>
    <dbReference type="EnsemblBacteria" id="ABB33073">
        <property type="protein sequence ID" value="ABB33073"/>
        <property type="gene ID" value="Gmet_2855"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2855"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_0_7"/>
    <dbReference type="OMA" id="GTIGAMQ"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="10"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="248" mass="26310" checksum="43049F41F0D2A660" modified="2005-11-22" version="1">MLTAEQSERYARHLILENVGEVGQERLLAGRVMVIGAGGLGSPVALYLAAAGVGTIGIADSDRVELSNLQRQIAHHTADLGRPKVVSAREKMAAMNPDVTVIPFETRVEASNIAEIIADFDFVIDATDNFAAKFLINDACVAAGKPFSHGGILRFNGQTMTVLPGESPCYRCIFPEPPESDEVATACSRAGVIGVLPGVIGTIQATEAIKYLMGIGELLTGRLLTYSALALKFREVPIKKKLTCPACG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S07</accession>
    <name>Q39S07_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1638 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511710.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2749"/>
    <dbReference type="EnsemblBacteria" id="ABB32967">
        <property type="protein sequence ID" value="ABB32967"/>
        <property type="gene ID" value="Gmet_2749"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2749"/>
    <dbReference type="eggNOG" id="ENOG5032QZS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099367_0_0_7"/>
    <dbReference type="OMA" id="IDARQNF"/>
    <dbReference type="OrthoDB" id="1919156at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012437">
        <property type="entry name" value="DUF1638"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07796">
        <property type="entry name" value="DUF1638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1638" evidence="1">
        <location>
            <begin position="32"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="193" mass="21893" checksum="E3ABF8E9301712C9" modified="2005-11-22" version="1">MPADVLVVSCGIFRDELAALGRAGKFPWPVRFLDSMLHMEPERLEQALTALVQSLAGQRIVLLFGDCQARMDLLASREGACRVKGHNCCELVLGREEYRRLRREGAFFLLPEWTARWREVFRERLGFVTPESARLFMQEMHRRIFYLDTGVVPVPAETLAEIGCYVGLPVEVKAVAPDRLADAVRKALEGFNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S12</accession>
    <name>Q39S12_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511715.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2744"/>
    <dbReference type="EnsemblBacteria" id="ABB32962">
        <property type="protein sequence ID" value="ABB32962"/>
        <property type="gene ID" value="Gmet_2744"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2744"/>
    <dbReference type="eggNOG" id="COG3753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084747_5_0_7"/>
    <dbReference type="OMA" id="WVSTGQN"/>
    <dbReference type="OrthoDB" id="1984170at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045372">
        <property type="entry name" value="YidB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027405">
        <property type="entry name" value="YidB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20159">
        <property type="entry name" value="YidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140804">
        <property type="entry name" value="SSF140804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="135" mass="13757" checksum="B1065BE362531FAE" modified="2005-11-22" version="1">MGLLDELVSKATGMLGGGQGEGQEGLLGGVMEMLGGQGGLGNLVQNFKDKGLGDIISSWVSTGQNLPINADQIKEGLGSETIQNLAAKVGISPDDLSSKLSELLPGVVDKLTPDGQIPEGGLLEKGLEFLKGKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S69</accession>
    <name>Q39S69_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32905.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32905">
        <property type="protein sequence ID" value="ABB32905"/>
        <property type="gene ID" value="Gmet_2687"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2687"/>
    <dbReference type="eggNOG" id="ENOG502ZMUP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174745_4_0_7"/>
    <dbReference type="OMA" id="QKPMSSV"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223325" evidence="2">
        <location>
            <begin position="19"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32905.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="67" mass="6560" checksum="535FBD3E88416F04" modified="2012-10-31" version="2">MKKLLSLTLCLAMAVAFAAGCKKKEEAPAPAPAEQAAPAPAAPAQAPMSSAKAPAPEAAPAAPAEHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SC3</accession>
    <name>Q39SC3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511829.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2632"/>
    <dbReference type="EnsemblBacteria" id="ABB32851">
        <property type="protein sequence ID" value="ABB32851"/>
        <property type="gene ID" value="Gmet_2632"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2632"/>
    <dbReference type="eggNOG" id="COG4704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125018_1_0_7"/>
    <dbReference type="OMA" id="IALYTHE"/>
    <dbReference type="OrthoDB" id="2066470at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018673">
        <property type="entry name" value="DUF2141"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09912">
        <property type="entry name" value="DUF2141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223204" evidence="1">
        <location>
            <begin position="23"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="142" mass="15275" checksum="309C5F25058BC331" modified="2005-11-22" version="1">MVRFAALLVACLLILQLKPAVAETLLVTVTGFRGVRGTLYVTVWGDEAHFLTDLRRAAARRVLPVSGPEMTVAVEGLSRGVYAVTAFQDENGNGELDRNFIGVPKEPAGVSNDARGMMGPPKFKAAAIVLDRASRSVPLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SF6</accession>
    <name>Q39SF6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ech-hydrogenase-related complex, HyfE-like integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ehrC-1</name>
        <name evidence="7" type="ordered locus">Gmet_2599</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511862.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2599"/>
    <dbReference type="EnsemblBacteria" id="ABB32818">
        <property type="protein sequence ID" value="ABB32818"/>
        <property type="gene ID" value="Gmet_2599"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2599"/>
    <dbReference type="eggNOG" id="COG4237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088957_1_0_7"/>
    <dbReference type="OMA" id="VFGYCLM"/>
    <dbReference type="OrthoDB" id="1806321at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038730">
        <property type="entry name" value="HyfE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38601">
        <property type="entry name" value="PTHR38601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="213" mass="23060" checksum="13B1D7B7D1DA776E" modified="2005-11-22" version="1">MSSFADQLLVLVMLINLIMLGTSRLMFSIRAVAAQGVILGILPGLIHPFSGHLASITVGIILAKGVAIPYFIGGAVRKAQIRREVEPFIGYVPTLLLGAVFTALSFVFAERLPLAPEHRDLLFVPASIATLLCGFLILTTRRKAISQVIGYLVMENGIFVFGLLLTEAMPVMVEAGALLDLLVGIFVMGIVINHISREFSSIDTSRLRALKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SK7</accession>
    <name>Q39SK7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32767.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513486.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32767">
        <property type="protein sequence ID" value="ABB32767"/>
        <property type="gene ID" value="Gmet_2548"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2548"/>
    <dbReference type="HOGENOM" id="CLU_2682548_0_0_7"/>
    <dbReference type="OMA" id="CFGIDEF"/>
    <dbReference type="OrthoDB" id="2214950at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32767.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="74" mass="8186" checksum="F6DFC495806BE16D" modified="2012-10-31" version="2">MLVEISFPLLQDISSPFILNCFGIDEFLLVFFIGLGTIAFACQLVPGVLLFVSMVRSIYSFPRPDTRPSAEGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SL2</accession>
    <name>Q39SL2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2543</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513491.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2543"/>
    <dbReference type="EnsemblBacteria" id="ABB32762">
        <property type="protein sequence ID" value="ABB32762"/>
        <property type="gene ID" value="Gmet_2543"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2543"/>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045686_1_1_7"/>
    <dbReference type="OMA" id="DPGIFWN"/>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="253" mass="27550" checksum="0F1F09DB8F18CEF7" modified="2005-11-22" version="1">MNPERTVKWFLQELQAFFVLSARAVVRIFRRPWYYREFITQLDKMGVGSLFIVCLTGLFTGMVMALQALIQLKPFAATSYVGGMVAVTMVKELGPVLSSLMVAGRVGSSITAELGTMVVTEQVDAMRVEGTDIITRLVTSRLKAMLVAMPLLAVVTDALALLGGYVIASGYDINLLMYWKSLSQFMVFQDLVEGVAKPFVFGFLIAMIGSYAGLTTSGGAEGVGAAAKRAVVVSSIMVLVCDFFMTKIFIVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SM4</accession>
    <name>Q39SM4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-dependent peptidase, M16 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514522.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2529"/>
    <dbReference type="EnsemblBacteria" id="ABB32750">
        <property type="protein sequence ID" value="ABB32750"/>
        <property type="gene ID" value="Gmet_2529"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2529"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_6_1_7"/>
    <dbReference type="OMA" id="RLMRYEY"/>
    <dbReference type="OrthoDB" id="1077305at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="2">
        <location>
            <begin position="67"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="3">
        <location>
            <begin position="208"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="479" mass="52761" checksum="D4713524767F3123" modified="2005-11-22" version="1">MIIVKRFALIILVALLPVVAFGAEAKKADPRTMTFPPLVFEVPKTERVVLNNGMVVHMLPDRELPLVSLTAYVNVGSIYEPADKTGLAGLTGAVMRSGGTRELAPSALDAELEFMASGVESSIGADSGGVSLTCLKRNLPRTLELFAQVMMAPAFSEDRVALAKKRTIEALRRQNDDSKEIADREFQKAVYPNHPLGRVPTVETVTAITRDDMVAFHREYFHPNNVILAVAGDFDKKEMIALLEKTFAGWKREEIAFPSVPEPAREVKPVVLLARKAVPQSAIRMGHPGIDKNNPDLYAIRVMDYILGGGFTSRLMTEIRSNEGLAYNVHASFDIGRRFIGTFEAETETKSETTAKAIGLMRAIIAGMTKEPVTDAELTLAKDSIINSFIFGFARTDAVVAQRARIEFYGYPEGYLENYRANIAKVTKDDVLRVARKYLKPDRMVTVVAGDDKTFDKPLSTFGTVEEIKLENGTEKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SN4</accession>
    <name>Q39SN4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux pump, RND family, membrane fusion lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366066.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2519"/>
    <dbReference type="EnsemblBacteria" id="ABB32740">
        <property type="protein sequence ID" value="ABB32740"/>
        <property type="gene ID" value="Gmet_2519"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2519"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_1_7"/>
    <dbReference type="OMA" id="RGCIDNR"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223481" evidence="3">
        <location>
            <begin position="20"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="63"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="382" mass="40434" checksum="4E471BD5770419C3" modified="2005-11-22" version="1">MNVSKICMHALLLFAVPLAGCKGDEAKKSPAVKPPVAVEVIAVAPRDLVEGVEVTGSLEPKFYADVKTQIPGLVKQVYVTEWLRVRKGTPLARIDVAEAEAMVKRAEASVESARAGLAQAQVGANRAERELTRILKLKESGLATQQGVDDARTESAAAQARIEAAQAQIRVAQEEVRQARARQAKGLVVSPLDGVVALRDVNVGDLASDAAASKPIFRIVDNRVLNLTVTVPSADSARVKVGQPLEFTVDALPGKTFMGRVMYINPELSSADRSLRVIAEVRNDGDRLKGGLFAKGRIITGQRPKVVQVPRGALTTWDTAARKGNLFIVAGTTAKLRQVETGAVSGDSVEIVKGVGAGEQIVARGGFNLKDGDTVSVAGGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SQ5</accession>
    <name>Q39SQ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anthranilate synthase, glutamine amidotransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trpG</name>
        <name evidence="2" type="ordered locus">Gmet_2496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514650.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2496"/>
    <dbReference type="EnsemblBacteria" id="ABB32719">
        <property type="protein sequence ID" value="ABB32719"/>
        <property type="gene ID" value="Gmet_2496"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2496"/>
    <dbReference type="eggNOG" id="COG0512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_1_2_7"/>
    <dbReference type="OMA" id="TEHGHAM"/>
    <dbReference type="OrthoDB" id="1561172at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GATase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="189" mass="20903" checksum="D09406CE0FA7F752" modified="2005-11-22" version="1">MLLMIDNYDSFTYNIVQYFGELGEDVRVFRNDGITLEEIERLAPERLVISPGPCSPEEAGISVAAIRHFAGKIPILGVCLGHQSIGAAFGGKVVRSSTLMHGKTSPIHHNGQGLFRGLPNPFNATRYHSLVVERATFPDCLEITAWVEEGEVMGLAHRELPIWGVQFHPESILTEGGMDILKNFLEMTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SS8</accession>
    <name>Q39SS8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Mannose-6-phosphate isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512428.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2471"/>
    <dbReference type="EnsemblBacteria" id="ABB32696">
        <property type="protein sequence ID" value="ABB32696"/>
        <property type="gene ID" value="Gmet_2471"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2471"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_4_1_7"/>
    <dbReference type="OMA" id="TYVPQCT"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MannoseP_isomer" evidence="1">
        <location>
            <begin position="7"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="126" mass="14505" checksum="6F0A835B0FB761F2" modified="2005-11-22" version="1">MLERGERPWGTYTVLEENTSYKIKRIEVNPGQRLSLQMHHHRSEHWIVVSGTARVTCGDEEYVVNVNESTFIPIGRNHRLENPGKIPLVIIEVQSGEYLGEDDIVRFDDDYNRCEPGTETFSGETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ST5</accession>
    <name>Q39ST5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Magnesium-dependent deoxyribonuclease, TatD family, and radical SAM domain iron-sulfur oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32689.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366057.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2464"/>
    <dbReference type="EnsemblBacteria" id="ABB32689">
        <property type="protein sequence ID" value="ABB32689"/>
        <property type="gene ID" value="Gmet_2464"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2464"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047239_0_0_7"/>
    <dbReference type="OMA" id="CSFCAKF"/>
    <dbReference type="OrthoDB" id="543500at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023821">
        <property type="entry name" value="rSAM_TatD-assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01111">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04038">
        <property type="entry name" value="tatD_link_rSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="271"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32689.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="462" mass="51241" checksum="4DB05E78E36DFF66" modified="2012-10-31" version="2">MNETGFLIDTHAHIDGHDFVADFDEVLGRAAEAGLSHIITVGADLESSQAACELARKHDHIYCAVGVHPHDASRVTERCYQVIRELAQGNPKVVAIGEIGLDFYRDRSPRDEQERVFRHFIRLARELALPIIVHDRDAHDRVMAILREEKAAEVGGVLHCFSGDLAMARECVEMGFYLSIPGTVTYPSNEQLREVVRGIRTEHLLIETDCPYLSPVPHRGKRNEPAYVRLTATKVAELKGLTLEDVGRITSLNARRLFGIGGKDQAARIAYRIRNSLYLNITNRCSNRCSFCAKFDDFTVKGHYLQLDHEPNFDEVMAAIGDPGPVDEVVFCGYGEPMLRIDLIREVAAELKKRGLRIRINTDGQANLVHGRNVLPELEGLIDCISVSLNAADAETYARLCNTPFGTAGFDGICRFLTEATKHIPKVVATAVTVPGVDIAAVRSLAETLGVEFREREYAEVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SU1</accession>
    <name>G6PI_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-6-phosphate isomerase</fullName>
            <shortName evidence="1">GPI</shortName>
            <ecNumber evidence="1">5.3.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoglucose isomerase</fullName>
            <shortName evidence="1">PGI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphohexose isomerase</fullName>
            <shortName evidence="1">PHI</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgi</name>
        <name type="ordered locus">Gmet_2458</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GPI family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512442.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SU1"/>
    <dbReference type="SMR" id="Q39SU1"/>
    <dbReference type="STRING" id="269799.Gmet_2458"/>
    <dbReference type="EnsemblBacteria" id="ABB32683">
        <property type="protein sequence ID" value="ABB32683"/>
        <property type="gene ID" value="Gmet_2458"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2458"/>
    <dbReference type="eggNOG" id="COG0166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033288_0_0_7"/>
    <dbReference type="OMA" id="CPAYAYG"/>
    <dbReference type="OrthoDB" id="417261at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="PTHR11469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000230918" description="Glucose-6-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00473"/>
        </source>
    </evidence>
    <sequence length="529" mass="56857" checksum="AEEC53EDC83FEB2D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SW3</accession>
    <name>Q39SW3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdpD</name>
        <name evidence="9" type="ordered locus">Gmet_2436</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512464.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2436"/>
    <dbReference type="EnsemblBacteria" id="ABB32661">
        <property type="protein sequence ID" value="ABB32661"/>
        <property type="gene ID" value="Gmet_2436"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2436"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_113_1_7"/>
    <dbReference type="OMA" id="LWATAFQ"/>
    <dbReference type="OrthoDB" id="1293707at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038318">
        <property type="entry name" value="KdpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025201">
        <property type="entry name" value="KdpD_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003852">
        <property type="entry name" value="Sig_transdc_His_kinase_KdpD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13493">
        <property type="entry name" value="DUF4118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02702">
        <property type="entry name" value="KdpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0407">Ion channel</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="674"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="888" mass="97720" checksum="81F35FCE5E6CD686" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T63</accession>
    <name>Q39T63_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513284.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2336"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32561">
        <property type="protein sequence ID" value="ABB32561"/>
        <property type="gene ID" value="Gmet_2336"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2336"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975773_0_0_7"/>
    <dbReference type="OMA" id="WHINHAP"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="66"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="146"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="285" mass="33749" checksum="4780B2AE6F65A01E" modified="2005-11-22" version="1">MIDDLLNFFNSFNVVKNYKLINQLKNEVDTLKSRLDIPRELLDGFYADRNSREYREVYEKDAPLVTVCIGTYNRGKLLVERSVRSVLEQSYGNIELIVVGDCCTDDTPRLVQGITDPRFRFINLPERGNYPENPLHRWCVAGTVPFNYALSQARGDFITHLDDDDEFVPDRIEKLVKFIQREKADLVWHPFWYERSNGRWAMRKAQEFSGGKVTTSSIFYHRWFTAVPWDIEAYRYQEPGDWNRLRKIKYLGARVARYPEPLLRHYCERNQESLSSRTIQTRNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TG7</accession>
    <name>Q39TG7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365985.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2230"/>
    <dbReference type="EnsemblBacteria" id="ABB32457">
        <property type="protein sequence ID" value="ABB32457"/>
        <property type="gene ID" value="Gmet_2230"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2230"/>
    <dbReference type="eggNOG" id="COG3804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050509_0_0_7"/>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045760">
        <property type="entry name" value="DAP_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19328">
        <property type="entry name" value="DAP_DH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DapB_N" evidence="3">
        <location>
            <begin position="12"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DAP_DH_C" evidence="4">
        <location>
            <begin position="145"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="367" mass="40979" checksum="D7A4850314AA5989" modified="2005-11-22" version="1">MRRETPYKVIVWAPGYLGTACIREILKRPEFELVGVLAYSESKNGKDVGELLGIDPIGVTMTTDQEKIFNMKADCVLHAGTNIMDDTPRNQEVVRLLESGKNVIAAPSYHFPQIHGPEFVAMLTNACQKGGVSLHGTGINPGFFAERLAVTLTGMVNEIDYIRCQEYFDLKNVEAVRMLKACTFGMTLEKAQSIIGRIEKGSENYYHSTVAHACHILGHDVERIAVKSTFTPAREDMHLKASGVTIKKGEVACWEHTWTGYVDGKPFFFLDEIFYLGQEYCPVETKGDHYRIIIEGKPVSVNMKMDLMASVEKDLHYREGDNTTPGYYATAMPMIQTIPVVCEAAPGIVYPTTFAHYARDYRNLVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TJ5</accession>
    <name>Q39TJ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-dependent flavin oxidoreductase, Oye family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2202</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365958.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2202"/>
    <dbReference type="EnsemblBacteria" id="ABB32429">
        <property type="protein sequence ID" value="ABB32429"/>
        <property type="gene ID" value="Gmet_2202"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2202"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_1_2_7"/>
    <dbReference type="OMA" id="GWVHRAH"/>
    <dbReference type="OrthoDB" id="1308229at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="2"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="383"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="688" mass="73289" checksum="3E0DF6E13BEE70B8" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TJ9</accession>
    <name>Q39TJ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365954.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2198"/>
    <dbReference type="EnsemblBacteria" id="ABB32425">
        <property type="protein sequence ID" value="ABB32425"/>
        <property type="gene ID" value="Gmet_2198"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2198"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_5_2_7"/>
    <dbReference type="OMA" id="TWEFDCH"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="378" mass="41289" checksum="6FFFB95B63EFD50C" modified="2005-11-22" version="1">MNYSLNDEQKILKDTARSFFTEELKSSLVREVEEDEQGYSRKLWESIAEFGWMGTIIPEEFGGFEATFFELSLILEEMGYAGYAGPFFSTVVLGALTILTAGTPEQKRSVLEEVSLGKRLMTLALEETGDGPSACEIATTAKKVADGFLLNGCKRFVPFAHVADTIICAARTGDGGKNGEEGISLFLVDRRSQGVSIEVLNTIARDKQCDVVFNNVLVSGDSLLGEAGEGWQLLQGVLRVASVAKCAEMVGGARKVLEMVVEYAKTRKQFGQPIGSFQAIQHHCANMLTCLDSSALLTFYASKRIGQGLSYEKEAAMCKAWVSDSYRKLTALGHQVMGGVGFIDESDLQIYFRRAKAAEQALGDATYHREIVAQLMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TM0</accession>
    <name>Q39TM0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2175"/>
    <dbReference type="EnsemblBacteria" id="ABB32404">
        <property type="protein sequence ID" value="ABB32404"/>
        <property type="gene ID" value="Gmet_2175"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2175"/>
    <dbReference type="eggNOG" id="ENOG5033C42">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653557_0_0_7"/>
    <dbReference type="OMA" id="ITGHHEA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="401" mass="45157" checksum="98353A0BB7D49888" modified="2005-11-22" version="1">MNSQSIHAMNQESFPECRSRFLGQGVVLLLWFANIYDMGGGFGIKYASFALAMLYLFLHFKPFPMDSQTSHLFMFLFLLWPVLSLLHSVIAGAELSLAISQMTAFPAAIVFFLVIQSVRPRYALSVFLYTMLSLAVIVIALYLLMWFTSPFADMFMRIFSSEAHGYIGYRPFGNIFMPNVYLKATLFLVPVYVYFLFMAKPIHALIALLALVVAFSKAGFALCLLFTLYFLFLHRGDRRYKAAVIVLFIAVTPLVLGFEQFTEELLRSLTGEAETAQVRIGYLDSLLAMFGEDPASLLIGQGPGAVFYARNLGAFVSNIELDHLNAIRKFGLPWFMAFTAFVLAVSYRLFRSQPAEERALGLALLSLFIAAGTNPVLLSPAFLMFMAMATDFYWRRDETAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TQ1</accession>
    <name>Q39TQ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513061.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32373">
        <property type="protein sequence ID" value="ABB32373"/>
        <property type="gene ID" value="Gmet_2144"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2144"/>
    <dbReference type="eggNOG" id="ENOG502ZAZX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_640548_0_0_7"/>
    <dbReference type="OMA" id="DKWPLVR"/>
    <dbReference type="OrthoDB" id="729267at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="428" mass="46440" checksum="503374D32C5729BF" modified="2005-11-22" version="1">MEKYAVRRMFKGQLATGFAALALSFIVAAFLWPAWSLTVKALYGILAGPGLSAAEPKEAGQLIGAVARGTFFWTAINSWIWLTLVMGNYGKTSLTEKQPWAGIYYTIVGWLVGAGAFLALISFMGIWWKPFSLAIMFVPRTAADVAMAFEAWEASNFYALAVIIAQIPLVSLLQKWPFAGKAEKPVESFGVIAMGIAVTFIVWMAMIVPSWMKLSLGGEQIVAPPFGNWPAFAAFCQAYVIFAIMPVEGGELYPMKLFTRKQPLMGIIGFAIALAAGFVMPPIIKGIIAPLNLVSGPPLDAVAASLELSVIVFMLAWHHLFEDYPSAALVPNTAARVCCRIAIWSIGGTVYGVIWLKTFKLIPYGANDLGMGVPPLGILAGQFALLMTLLFLNTFFDKWPLVRKVPLSVPEDIPLPADEQAGFEAMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U48</accession>
    <name>Q39U48_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512953.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1997"/>
    <dbReference type="EnsemblBacteria" id="ABB32226">
        <property type="protein sequence ID" value="ABB32226"/>
        <property type="gene ID" value="Gmet_1997"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1997"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183667_0_0_7"/>
    <dbReference type="OrthoDB" id="84156at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223271" evidence="1">
        <location>
            <begin position="21"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="234" mass="24944" checksum="3A202D1311DB3C9F" modified="2005-11-22" version="1">MAKLAAKLTMRMLLAGLALADVSWGADIPPAIEFLSPREGTTVHGEISIEARVSNPSVVDFVEFYLQEPGAKDRYAWREYGLPPYVWGGKGYKLDTRLFADGPASVVLYCYTGGAKPASEKRVHFTIDNSKPVVRIVSPTDRSSVDGAFPVKVELIASKGKGNPGGVVAVSVLVDGTLVQKMTKPPFETSVDTCLMAPGLHLIRVVAENGEGLTGSDSVLINRKAGTGLLRGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UD1</accession>
    <name>Q39UD1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response receiver sensor diguanylate cyclase, GAF domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2019" name="Elife" volume="8" first="0" last="0">
            <title>Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration.</title>
            <authorList>
                <person name="Hallberg Z.F."/>
                <person name="Chan C.H."/>
                <person name="Wright T.A."/>
                <person name="Kranzusch P.J."/>
                <person name="Doxzen K.W."/>
                <person name="Park J.J."/>
                <person name="Bond D.R."/>
                <person name="Hammond M.C."/>
            </authorList>
            <dbReference type="PubMed" id="30964001"/>
            <dbReference type="DOI" id="10.7554/eLife.43959"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.35 ANGSTROMS) OF 294-459</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511930.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="6D9M">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.35 A"/>
        <property type="chains" value="A=294-459"/>
    </dbReference>
    <dbReference type="PDBsum" id="6D9M"/>
    <dbReference type="SMR" id="Q39UD1"/>
    <dbReference type="STRING" id="269799.Gmet_1914"/>
    <dbReference type="EnsemblBacteria" id="ABB32143">
        <property type="protein sequence ID" value="ABB32143"/>
        <property type="gene ID" value="Gmet_1914"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1914"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_28_7"/>
    <dbReference type="OMA" id="FNTRYLH"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="323"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="6D9M"/>
        </source>
    </evidence>
    <sequence length="459" mass="51517" checksum="3C30C4A8FBAF3F76" modified="2005-11-22" version="1">MDKILVVEDDRFFRQMYVDLLKEDGYEVDTVTSGARALELLSANDYQLVITELVIPGMSGIELLTRVKQQMPTVDVILVTGHANVESAVLALKSGARDYLLKPFNHEEFKHTVALCFEQRRLINENYELKELLNLFQIGQNIANCIDMERLSAVVLDALTNEIGADRAIGLFHHKDDNLALKEFKGFSEEAAQKLAEAFRKNFCIETNDGSVINKINATPLVSGAEFDGLELSEGLLLVIRSKGEVQGVVVIFNNPGQKLPFDYKQKSIQFLLEQSTLAFENASRYSNARDMLYIDELTGLFNYRYLDISLDREIKRADRFGSTVSMIFIDLDFFKGVNDTHGHLVGSQVLNEMGMLLKKSVREVDIVIRYGGDEFTVMLVETGEKGAATVAERIRRSIEGHTFLAAEGFNIRLTASLGYACYPADTQSKLELLELADKAMYQGKEQGKNCVFRATAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UF1</accession>
    <name>Q39UF1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RecBCD enzyme subunit RecC</fullName>
            <ecNumber evidence="6">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Exonuclease V subunit RecC</fullName>
            <shortName evidence="6">ExoV subunit RecC</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Helicase/nuclease RecBCD subunit RecC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">recC</name>
        <name evidence="8" type="ordered locus">Gmet_1894</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild-type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RecC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511950.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1894"/>
    <dbReference type="EnsemblBacteria" id="ABB32123">
        <property type="protein sequence ID" value="ABB32123"/>
        <property type="gene ID" value="Gmet_1894"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1894"/>
    <dbReference type="eggNOG" id="COG1330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007513_0_0_7"/>
    <dbReference type="OMA" id="SFDLMQY"/>
    <dbReference type="OrthoDB" id="1320159at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009338">
        <property type="term" value="C:exodeoxyribonuclease V complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01486">
        <property type="entry name" value="RecC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006697">
        <property type="entry name" value="RecC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041500">
        <property type="entry name" value="RecC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17946">
        <property type="entry name" value="RecC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000980">
        <property type="entry name" value="RecC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01450">
        <property type="entry name" value="recC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecC_C" evidence="7">
        <location>
            <begin position="783"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1060" mass="118536" checksum="9CA43F2C396DCB7A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UF7</accession>
    <name>Q39UF7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Diadenylate cyclase</fullName>
            <shortName evidence="10">DAC</shortName>
            <ecNumber evidence="10">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="10">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dacA</name>
        <name evidence="12" type="ordered locus">Gmet_1888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511956.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1888"/>
    <dbReference type="EnsemblBacteria" id="ABB32117">
        <property type="protein sequence ID" value="ABB32117"/>
        <property type="gene ID" value="Gmet_1888"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1888"/>
    <dbReference type="eggNOG" id="COG1624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038561_0_1_7"/>
    <dbReference type="OMA" id="ILWQGEL"/>
    <dbReference type="OrthoDB" id="1300262at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014046">
        <property type="entry name" value="C-di-AMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004793">
        <property type="entry name" value="UCP004793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="11">
        <location>
            <begin position="80"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="255" mass="27833" checksum="BE3006BC03D7FBF0" modified="2005-11-22" version="1">MPDSLQLFGWRDLVDITLVTFIIYRVILLLKGKVAARLLLILAILGTLYFLTSLVGLDTLHWILRSLFGSFIIILVIVFQHDLRRALVSLGRSGKERDYEVEEASEAIDGLTTALADLSARRHGALIVIEREMGVSAHLQTGTEIDAKITSEILTSIFLPYSPIHDGAVVIQRGKLTKAGCFLPLSQNPAISKSLGTRHRAALGLTEVVDAVALVVSEETGQMSVVIGGKLMPMPDGGSLRKALKRLIEPQWLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UL8</accession>
    <name>Q39UL8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Indolepyruvate oxidoreductase subunit IorA</fullName>
            <shortName evidence="13">IOR</shortName>
            <ecNumber evidence="3 13">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 13">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="primary">iorA-1</name>
        <name evidence="16" type="ordered locus">Gmet_1827</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 13">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="13 14">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of the IorA and IorB subunits.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="3 13"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512018.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1827"/>
    <dbReference type="EnsemblBacteria" id="ABB32056">
        <property type="protein sequence ID" value="ABB32056"/>
        <property type="gene ID" value="Gmet_1827"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1827"/>
    <dbReference type="eggNOG" id="COG4231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017727_0_0_7"/>
    <dbReference type="OMA" id="IGDSTFM"/>
    <dbReference type="OrthoDB" id="342322at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017721">
        <property type="entry name" value="IorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006439">
        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03336">
        <property type="entry name" value="IOR_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 13 14" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13 14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="523"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="15">
        <location>
            <begin position="557"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR006439-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB32056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="585" mass="63115" checksum="2DCADEDB01B9571E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UP7</accession>
    <name>Q39UP7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Type II restriction endonuclease, zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1797</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512049.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1797"/>
    <dbReference type="REBASE" id="11548">
        <property type="entry name" value="GmeMrrP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32027">
        <property type="protein sequence ID" value="ABB32027"/>
        <property type="gene ID" value="Gmet_1797"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1797"/>
    <dbReference type="eggNOG" id="COG0551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050636_0_0_7"/>
    <dbReference type="OMA" id="EKYLVQC"/>
    <dbReference type="OrthoDB" id="1999861at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003916">
        <property type="term" value="F:DNA topoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Mrr_cat" evidence="3">
        <location>
            <begin position="108"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="zf-C4_Topoisom" evidence="2">
        <location>
            <begin position="242"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="zf-C4_Topoisom" evidence="2">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="355" mass="38706" checksum="E35C4CE82182F57D" modified="2005-11-22" version="1">MARQRTSPMEDMILVASKLPWWACLLLALVSYAVLHTMAMRPVMPATVVPGQMGDAVARGLITTLAMFGQYVMPFAFALAALLSAVTSSRQKKLYDTVAGRGDVAALNEMGWDEFEMLVGEHFRRQGFQVTRQGGNGPDGGVDLILKNGGETYLVQCKQWKAYKVGVQPVRELYGVMASRGAVGGYVVTSGKFTDEAVDFARGLNVELIDGRQLRQIIDNARRPSTDVVRHEIFPKAVSSPNCPKCGAEMKKRVARQGSNAGREFWGCSTYPKCKGIVPVTINQDTDQAKVTMQPTIPPVDASKKLCPQCGEELVLRQFQSGPRIGQQFYGCLTCKKGWPVDTLAQHAALADGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39US0</accession>
    <name>Q39US0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513330.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1773"/>
    <dbReference type="EnsemblBacteria" id="ABB32004">
        <property type="protein sequence ID" value="ABB32004"/>
        <property type="gene ID" value="Gmet_1773"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1773"/>
    <dbReference type="eggNOG" id="COG3169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133782_0_0_7"/>
    <dbReference type="OMA" id="WYGHLKH"/>
    <dbReference type="OrthoDB" id="1929935at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007437">
        <property type="entry name" value="DUF486"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38482">
        <property type="entry name" value="PTHR38482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04342">
        <property type="entry name" value="DMT_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021239">
        <property type="entry name" value="UCP021239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="109" mass="12444" checksum="7DD6B1641C57FCC3" modified="2005-11-22" version="1">MRTIVLLALSNIFMTFAWYAHLKNLRAAPWYIAVIVSWGIAFFEYLIQVPANRMGYGTFSLGQLKIMQEVITLAVFVPFAVYYMGQPLKLDYLWAACCLAGAVFFIFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39US6</accession>
    <name>Q39US6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Signal peptidase I</fullName>
            <ecNumber evidence="3 6">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">lepB</name>
        <name evidence="9" type="ordered locus">Gmet_1767</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peptidase S26 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="3 6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513336.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1767"/>
    <dbReference type="MEROPS" id="S26.025"/>
    <dbReference type="EnsemblBacteria" id="ABB31998">
        <property type="protein sequence ID" value="ABB31998"/>
        <property type="gene ID" value="Gmet_1767"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1767"/>
    <dbReference type="eggNOG" id="COG0681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028723_1_3_7"/>
    <dbReference type="OMA" id="IEPRWIP"/>
    <dbReference type="OrthoDB" id="1741894at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43390">
        <property type="entry name" value="PTHR43390"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S26" evidence="8">
        <location>
            <begin position="32"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="226" mass="25888" checksum="C6C785E760F0E824" modified="2005-11-22" version="1">MDYKNSQYGSNNAMGERPAAEEPQVKKKHIVREYAESIIIAVILALIIRTFVVQAFKIPSGSMEDTLAIGDHILVCKFIYGTKIPFTDMKIAPIREPKRGDVIVFEYPEDPSKDFIKRVIGVPGDEIRVIMKTVYVNGKPYKIPQEVHKENEVIAAAQNPRDNFGPVTVPAGSYFVMGDNRDRSYDSRFWGFVKSEQIKGLAFIKYWSWDRDNMRVRWKSIGDLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39US9</accession>
    <name>Q39US9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein YhbY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yhbY</name>
        <name evidence="4" type="ordered locus">Gmet_1764</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31995.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513340.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1764"/>
    <dbReference type="EnsemblBacteria" id="ABB31995">
        <property type="protein sequence ID" value="ABB31995"/>
        <property type="gene ID" value="Gmet_1764"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1764"/>
    <dbReference type="eggNOG" id="COG1534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095994_1_2_7"/>
    <dbReference type="OMA" id="FQVGKNG"/>
    <dbReference type="OrthoDB" id="2034603at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001890">
        <property type="entry name" value="RNA-binding_CRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017924">
        <property type="entry name" value="RNA-binding_YhbY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035920">
        <property type="entry name" value="YhbY-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01985">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01103">
        <property type="entry name" value="CRS1_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75471">
        <property type="entry name" value="SSF75471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00253">
        <property type="entry name" value="RNA_bind_YhbY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51295">
        <property type="entry name" value="CRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="CRM" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31995.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="98" mass="10920" checksum="B940D520265226F4" modified="2012-10-31" version="2">MLTGKQKRFLRGMGHSLNPVITVGKGEISTPLVRETSEALEHHELIKVKILESCIMDRHEVADELAKACGAEVAQVLGRTFLLYRKAEEPKLELPKGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UT1</accession>
    <name>DGTL1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyguanosinetriphosphate triphosphohydrolase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_1762</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dGTPase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513342.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UT1"/>
    <dbReference type="SMR" id="Q39UT1"/>
    <dbReference type="STRING" id="269799.Gmet_1762"/>
    <dbReference type="PRIDE" id="Q39UT1"/>
    <dbReference type="EnsemblBacteria" id="ABB31993">
        <property type="protein sequence ID" value="ABB31993"/>
        <property type="gene ID" value="Gmet_1762"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1762"/>
    <dbReference type="eggNOG" id="COG0232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028163_1_0_7"/>
    <dbReference type="OMA" id="HCKAFRR"/>
    <dbReference type="OrthoDB" id="370035at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016793">
        <property type="term" value="F:triphosphoric monoester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01212">
        <property type="entry name" value="dGTPase_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006261">
        <property type="entry name" value="dNTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023023">
        <property type="entry name" value="dNTPase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026875">
        <property type="entry name" value="PHydrolase_assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13286">
        <property type="entry name" value="HD_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01353">
        <property type="entry name" value="dGTP_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000138919" description="Deoxyguanosinetriphosphate triphosphohydrolase-like protein">
        <location>
            <begin position="1"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="75"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="385" mass="44772" checksum="78A48265E564BD52" modified="2005-11-22" version="1">MTEGVEGRSQERSDLAGFAARSAESRGRKYQEAFRDHRPAFERDRDRIIHCAAFRRLEYKTQVFVNHEGDYYRTRLTHSLEVAQIGKAIARRLGVNEELTEALALAHDLGHTPFGHTGEEVLNRLMEGFGGFEHNLQSFRVVDQLEERYPGFNGLNLSWEVLEGIVKHSSPYDRPVGVIDRFLPGVVPTIEAQIINYADEIAYNNHDIDDGLKSGFITLDQLDGVELWREVHEGIARAYPDIDPERRKLQTISALIGVFIKDLTTTSLENVQRLRITSLDDLRRINRPVVAFSPATAEKNRKLKGFLFENLYRHYRVERMRVKAERYLRQLFESYVKHPTLLPRKYQKKMEILGRERVVCDYIAGMTDRFALDEFKRLFEPYERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UX9</accession>
    <name>Q39UX9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Electron transfer flavoprotein-associated cytochrome b and CCG domain pair iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_1714</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514140.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1714"/>
    <dbReference type="EnsemblBacteria" id="ABB31945">
        <property type="protein sequence ID" value="ABB31945"/>
        <property type="gene ID" value="Gmet_1714"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1714"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_7"/>
    <dbReference type="OMA" id="IMLQADF"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB31945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="671" mass="74902" checksum="182B7079859CD1D5" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UZ2</accession>
    <name>Q39UZ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Radical SAM domain iron-sulfur cluster-binding oxidoreductase with cobalamin-binding-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1701</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514153.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1701"/>
    <dbReference type="EnsemblBacteria" id="ABB31932">
        <property type="protein sequence ID" value="ABB31932"/>
        <property type="gene ID" value="Gmet_1701"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1701"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_7_0_7"/>
    <dbReference type="OMA" id="YAETWRR"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="185"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="469" mass="53419" checksum="3836D5506A5E9E1F" modified="2005-11-22" version="1">MNILLLRPHPGSDAFGLGPFFRVEPLGLEYLGAALLARGHAVTIADLRFRPGASTWVRRSQPRLVGITCLHALEYDRIIATAREVRRVSPDAFILVGGHAAAAFPDPLKDNVIDAICLDDGEEIITALAEALETGRPLTDIPALLFRTGDGWVETPPLSDQTCLDLVPLPARHLVDRHRNNYHCLLFKPVWLIETARGCPHRCSFCSVWQLYGRSVRERSIATVVEDFATAGDSIFVADDLFWYNRERSIELAEALKKRGVHKRWILVQTRTDLICRSADIMAAWRPLAKDFDIFLGLEAASDKGLSGLDKDAGLAESIEGVRIARELKYGINGNFLVGHDWGEEEFRELWDFVAQYGLQRAGFTIHTPLPGTDHYREMKPRIPDQPWSNFDMHHLLWEPRIGAKRFFELYAETWRRSILNTSGEKSIVDWMRQVRPSQIPYIARVLWRTQRMMKPAAYLKEYEATRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V16</accession>
    <name>Q39V16_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycerol-3-phosphate dehydrogenase, FAD-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glpA</name>
        <name evidence="8" type="ordered locus">Gmet_1677</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511387.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1677"/>
    <dbReference type="EnsemblBacteria" id="ABB31908">
        <property type="protein sequence ID" value="ABB31908"/>
        <property type="gene ID" value="Gmet_1677"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1677"/>
    <dbReference type="eggNOG" id="COG0578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015740_4_1_7"/>
    <dbReference type="OMA" id="CIVNAAG"/>
    <dbReference type="OrthoDB" id="360065at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004368">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031656">
        <property type="entry name" value="DAO_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038299">
        <property type="entry name" value="DAO_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000447">
        <property type="entry name" value="G3P_DH_FAD-dep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11985">
        <property type="entry name" value="PTHR11985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16901">
        <property type="entry name" value="DAO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01001">
        <property type="entry name" value="FADG3PDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="6">
        <location>
            <begin position="17"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="DAO_C" evidence="7">
        <location>
            <begin position="415"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="516" mass="56063" checksum="6F064B3BE6FB3D48" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V27</accession>
    <name>Q39V27_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux pump, RND family, outer membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1666</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511397.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1666"/>
    <dbReference type="EnsemblBacteria" id="ABB31897">
        <property type="protein sequence ID" value="ABB31897"/>
        <property type="gene ID" value="Gmet_1666"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1666"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_13_0_7"/>
    <dbReference type="OMA" id="DFWGRFS"/>
    <dbReference type="OrthoDB" id="1619477at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="524"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="546" mass="59976" checksum="55B9DB22C772A489" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V71</accession>
    <name>Q39V71_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Deoxycytidylate deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1622</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511442.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1622"/>
    <dbReference type="EnsemblBacteria" id="ABB31853">
        <property type="protein sequence ID" value="ABB31853"/>
        <property type="gene ID" value="Gmet_1622"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1622"/>
    <dbReference type="eggNOG" id="COG2131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047993_2_3_7"/>
    <dbReference type="OMA" id="TKWYVLH"/>
    <dbReference type="OrthoDB" id="1544522at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016473">
        <property type="entry name" value="dCMP_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="PTHR11086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006019">
        <property type="entry name" value="dCMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="154" mass="16863" checksum="CF990FDDF3C07DEF" modified="2005-11-22" version="1">MTRPTWDEYFMEITHLVAKRSTCLRRQVGAVIVKDKNILATGYNGAPSGVAHCLEVGCLRAKLGIPSGERHELCRGLHAEQNAIIQAAKHGINIDGGTLYCTTMPCIICSKMLINAGIRRVVYEEGYSDELAREMIGESGVVVEKFGDIRGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V85</accession>
    <name>Q39V85_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY-4</name>
        <name evidence="3" type="ordered locus">Gmet_1607</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511458.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1607"/>
    <dbReference type="EnsemblBacteria" id="ABB31839">
        <property type="protein sequence ID" value="ABB31839"/>
        <property type="gene ID" value="Gmet_1607"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1607"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_7"/>
    <dbReference type="OMA" id="DSPMWRK"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="119" mass="13061" checksum="A400DDBE61E18889" modified="2005-11-22" version="1">MKKVLIVDDSISVARQLEKILADSGEFQVVGHGKNGMEAIRMHQTEHPDIICMDMNMPGMDGLTALRTLVALDKNVKVVMITSLGGVGDKFTEALRLGARTVISKPFEADDILKILREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VF5</accession>
    <name>Q39VF5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Aromatic hydrocarbon degradation outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1535</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OmpP1/FadL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511531.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1535"/>
    <dbReference type="EnsemblBacteria" id="ABB31769">
        <property type="protein sequence ID" value="ABB31769"/>
        <property type="gene ID" value="Gmet_1535"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1535"/>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035981_1_1_7"/>
    <dbReference type="OMA" id="WDDSWLF"/>
    <dbReference type="OrthoDB" id="620166at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005017">
        <property type="entry name" value="OMPP1/FadL/TodX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35093">
        <property type="entry name" value="PTHR35093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03349">
        <property type="entry name" value="Toluene_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="453" mass="48227" checksum="045A45D0DE95B913" modified="2005-11-22" version="1">MKYKIVTPYTLAMVAIIVSTTLRVSYATDVFRLEGFGPVSRGMGGAATAFDVGAAGMMTNPATLSLMGAGSEIHVGLDVVVTDISAKNKATGENASSDSHSNNRGPYAAPEAGFVYRAAPLTLGFGAFAQGGLGTEYGRNTFLSRASGNLDTGLDNSSRLLVLNVPFAITYDINEKLTIGAAIDAMWEGLNLELLLPAEDVGALIQGGRVTGSLLPVLGGLPDLRGAHFSMTKNQPIASGIDAWGFGARIGGVYKLSKDTIIGAAYTMESRMADMEGNATMTAVDGSAGQIPLKGKIKLGGLQMPAQLDIGVSHQINEHWLVVADISRVFWKNAVKDLKVHFVTDNGEDIHISLPQNYKDQMIYSLGVAYRTGHWTLRCGGRIASQAMRSDTVIAVIPAIPTKHASAGFSYDFSAANTVDFAYSHAFEESFDNANTRLVHSQNNFSIAYTHRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VP3</accession>
    <name>Q39VP3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein tyrosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511622.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1447"/>
    <dbReference type="EnsemblBacteria" id="ABB31681">
        <property type="protein sequence ID" value="ABB31681"/>
        <property type="gene ID" value="Gmet_1447"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1447"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703502_0_0_7"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CbiA" evidence="2">
        <location>
            <begin position="217"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="392" mass="42961" checksum="D660EBF9DF011C13" modified="2005-11-22" version="1">MAETSTALERMRKKVLESARSDSQEAVSTEAPRLKAALPAPETEAVVFEPVEQRAETAPKRKLSTLGRMGKTAFGLISSRRENALPATVDSGTAADLQYEATQPMAEVDTCCGNLAVQAPEPVVSPDEVIDTAGVSCPEEPCIDHTDDKRQPSVVNREKIGWVSPAYTVSRSVRLDPQLVARNKCVAFLSDADEVESYRVLRTQILQRSRERGGNTIMITSALPGEGKTLTAINLALTFAKEFRQTALLVDCDLRRQRIHELLGIGGEKGLNDYLLDDCPISDLMVWPGVEKLTLISGGRTITESSELLGSPRMKELVEDMKHRYPERYVIFDVPAVLSGADALAFAPLVDHIVVTVKAGETPMSEVTRAIRMLPREKVLGVVLNRRRRGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VP8</accession>
    <name>Q39VP8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511627.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1442"/>
    <dbReference type="EnsemblBacteria" id="ABB31676">
        <property type="protein sequence ID" value="ABB31676"/>
        <property type="gene ID" value="Gmet_1442"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1442"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050993_2_0_7"/>
    <dbReference type="OMA" id="FACKLKG"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="217" mass="24694" checksum="54B30DC8B7474CE6" modified="2005-11-22" version="1">MKVYAVNGSPRKNWNTAMLLEHALSGAASQGAETELIHLYDLTFKGCTSCFACKLKEGKSYGKCAMKDGLTPALEKLATADAFILGSPIYFGTVTGEMRSFMERLLFQYLAYTRPPSSLFTRNIPTAFIYTMNVSEEIMKENQYPIHIGMNENYLARIFGQAETLCSYETLQFEDYDKVVFNYFDPEERRQRRRDVFPEDCRKASELGARLARSARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VQ7</accession>
    <name>Q39VQ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1433"/>
    <dbReference type="EnsemblBacteria" id="ABB31667">
        <property type="protein sequence ID" value="ABB31667"/>
        <property type="gene ID" value="Gmet_1433"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1433"/>
    <dbReference type="eggNOG" id="ENOG502ZMJ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_207151_0_0_7"/>
    <dbReference type="OMA" id="CVVCAWR"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="51" mass="5670" checksum="55F9743BD5EC2296" modified="2005-11-22" version="1">MSSSKRQACVVCAWRETCAKKFCVTDGGARCPDFSRDVSIKVPDEESDEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VW5</accession>
    <name>Q39VW5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance efflux pump, RND family, membrane fusion protein EmrA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513133.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1375"/>
    <dbReference type="EnsemblBacteria" id="ABB31609">
        <property type="protein sequence ID" value="ABB31609"/>
        <property type="gene ID" value="Gmet_1375"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1375"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_15_1_7"/>
    <dbReference type="OMA" id="VQITPQI"/>
    <dbReference type="OrthoDB" id="1680841at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="6">
        <location>
            <begin position="71"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="5">
        <location>
            <begin position="307"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="135"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="374" mass="40439" checksum="EA5C58DCB34E4FD3" modified="2005-11-22" version="1">MAVEESKENQGAGETARTATDTAGPAGKQRGGKRTRAGIILLAVIAIGLFMGTHWFLRSKTLITTDNAFVEAHIHAISPRVSGTVTAVPVMDNQFVKKGETLVELDPTDYEVRVRSAAADLDMARNETSGDYAQVEAARAAVSHARARLDQAELDLRRGSVLFTKEVIPREQLDRLETARRVTAAQLREAEEGVRKAQAELGLAGTGGKEARVAQREAKLREASLSLSYTRIVAPVDGYVTRKSVETGSTVQAGQPLMAVVALNDTWVTANYKESQLAHMKPGQKVTFTVDAYPSRTFTGRVDSIMAGTGAAFSLLPSENATGNYVKVVQRVPVKIVVDTGSDPRHLLRVGMSVIPTVNTGRKLGEILRDFRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W57</accession>
    <name>Q39W57_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipopolysaccharide export system protein LptA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">lptA</name>
        <name evidence="5" type="ordered locus">Gmet_1281</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the lipopolysaccharide transport and assembly complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LptA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512085.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1281"/>
    <dbReference type="EnsemblBacteria" id="ABB31517">
        <property type="protein sequence ID" value="ABB31517"/>
        <property type="gene ID" value="Gmet_1281"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1281"/>
    <dbReference type="eggNOG" id="COG1934">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095993_7_1_7"/>
    <dbReference type="OMA" id="YFINEQR"/>
    <dbReference type="OrthoDB" id="1696422at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001530">
        <property type="term" value="F:lipopolysaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015920">
        <property type="term" value="P:lipopolysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01914">
        <property type="entry name" value="LPS_assembly_LptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014340">
        <property type="entry name" value="LptA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03968">
        <property type="entry name" value="LptD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03002">
        <property type="entry name" value="outer_YhbN_LptA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019137" description="Lipopolysaccharide export system protein LptA" evidence="3">
        <location>
            <begin position="22"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="OstA-like_N" evidence="4">
        <location>
            <begin position="35"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="169" mass="18225" checksum="5B55B25EBC881062" modified="2005-11-22" version="1" precursor="true">MKRMLTVLLFLVVVSLGTAHSAQLPKGGRQGQPITIKSNELSTDSRHNTATFTGKVIARQGDLTIYADKLVVHYKADGGDLDRVEASGNVRIVQGDRLATARDGVYQSAEQKIVLTGDPKVFQGENTVSGKVITYFVDEEKSIVTGGPDTRVEAVITPKEKGKDGGQQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WC3</accession>
    <name>Q39WC3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512156.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1214"/>
    <dbReference type="EnsemblBacteria" id="ABB31451">
        <property type="protein sequence ID" value="ABB31451"/>
        <property type="gene ID" value="Gmet_1214"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1214"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336204_0_0_7"/>
    <dbReference type="OMA" id="FERCNRW"/>
    <dbReference type="OrthoDB" id="501078at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="219" mass="24108" checksum="902534F700DC3E55" modified="2005-11-22" version="1">MPLHAFGHNRKTSPPPTPWEPRQVFLFSGHMIDAPDRPEPRFPADKETVAAAAIAAMLDELGAGPDDLALCSGACGGDILFTEACLARGVRVDMGIPFGIPEFLTRSVTFAGEEWRDRFFAIKNNPLVTLFVMPDELGPCPADLSPYVRTNLWLLHTALAWGEEKVHFICLWNRKGGDGPGGTEHMHDEVNKRTGQVHVLDTNKLFTHEGTPLAEKLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WE3</accession>
    <name>Q39WE3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365782.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1194"/>
    <dbReference type="EnsemblBacteria" id="ABB31431">
        <property type="protein sequence ID" value="ABB31431"/>
        <property type="gene ID" value="Gmet_1194"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1194"/>
    <dbReference type="eggNOG" id="ENOG502Z7KR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_254719_0_0_7"/>
    <dbReference type="OMA" id="TELWHTR"/>
    <dbReference type="OrthoDB" id="849378at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="896"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1500" mass="161286" checksum="58BAB80464FD81C6" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WE8</accession>
    <name>Q39WE8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">corA-1</name>
        <name evidence="7" type="synonym">corA</name>
        <name evidence="8" type="ordered locus">Gmet_1189</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31426.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365781.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1189"/>
    <dbReference type="EnsemblBacteria" id="ABB31426">
        <property type="protein sequence ID" value="ABB31426"/>
        <property type="gene ID" value="Gmet_1189"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1189"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_0_0_7"/>
    <dbReference type="OMA" id="IQKYFRD"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31426.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="356" mass="40777" checksum="81A3A0714ED394A8" modified="2012-10-31" version="2">MRNKLVTKRSAKAGLPPGTLVHIGERHREAARVSIIAYDEKGVYEQASDDLAACFPLRNQPEVSWINVEGIHSIELLQKLGECYGIHPLVLEDILNTDQRPKREDYGAYLFIVLKMLSLKNGNKGVAAEQMSLILGENFVLSFQEGLAGDPFDPVRERLRAGRGKIRSLGADYLVYSLIDAIIDNYFVILESLAERIERLEEELVANPVRETVGRLHILKREVIFLRKSIWPLREVISGLERRESSLVREETAIYLRDVYDHTVQIIDTVETFRDILSGLLDIYLSTLSNRTNEVMKVLTIIATLFMPLTFIAGLYGMNFHYMPELNWRWGYPAVLILMLLVIGGMLVFFRRKKWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WF5</accession>
    <name>Q39WF5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2',3'-cyclic nucleotide 2'-phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1181"/>
    <dbReference type="EnsemblBacteria" id="ABB31419">
        <property type="protein sequence ID" value="ABB31419"/>
        <property type="gene ID" value="Gmet_1181"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1181"/>
    <dbReference type="eggNOG" id="COG1692">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068238_0_0_7"/>
    <dbReference type="OMA" id="NHIWDKK"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005235">
        <property type="entry name" value="YmdB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36303">
        <property type="entry name" value="PTHR36303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13277">
        <property type="entry name" value="YmdB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004789">
        <property type="entry name" value="DR1281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00282">
        <property type="entry name" value="TIGR00282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004789-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="264" mass="28885" checksum="2E4C15FE5CAB52FF" modified="2005-11-22" version="1">MSMPVNILFIGDIVGAPGRQAVSRELHRLIDRYRIDLVIANGENAAGGFGITEEKARELYSLGIDVLTSGNHVWDKKESYPYIRREERLVRPANYPPETIGRGSTVVRTAGGISIGILNLEGRVFMNSLDCPFRAADREIVQLKEQANIIFVDFHAEATSEKVALGWYLDGKVSAVVGTHTHVQTADERILPGGTAYMTDAGMTGSFDSVIGVKKELAVERFTSQMPVRFEVAKKDIRLNGVVLGIDEMSGSALSVERISLTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WF9</accession>
    <name>Q39WF9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein ZapB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">zapB</name>
        <name evidence="2" type="ordered locus">Gmet_1177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31415.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513443.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1177"/>
    <dbReference type="EnsemblBacteria" id="ABB31415">
        <property type="protein sequence ID" value="ABB31415"/>
        <property type="gene ID" value="Gmet_1177"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1177"/>
    <dbReference type="HOGENOM" id="CLU_171174_3_0_7"/>
    <dbReference type="OMA" id="VSLMNVV"/>
    <dbReference type="OrthoDB" id="2093705at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31415.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="58" mass="6889" checksum="0423F301A43CAFE6" modified="2012-10-31" version="2">MDTELFTDLERRVETLVERYTALKRENDVLREENGRLLQERDAVKSRIDGVLRKLEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WM6</accession>
    <name>Q39WM6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513764.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1108"/>
    <dbReference type="EnsemblBacteria" id="ABB31348">
        <property type="protein sequence ID" value="ABB31348"/>
        <property type="gene ID" value="Gmet_1108"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1108"/>
    <dbReference type="eggNOG" id="ENOG5033EDZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160686_1_0_7"/>
    <dbReference type="OMA" id="CGEPAAK"/>
    <dbReference type="OrthoDB" id="1658916at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021268">
        <property type="entry name" value="DUF2845"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11006">
        <property type="entry name" value="DUF2845"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="112" mass="12149" checksum="71E31C3D780D6EC2" modified="2005-11-22" version="1">MNGKTGFIGIILLALVPWNAGATETGTMICRGGIVSIGDAIPEVLQKCGPPAFSSQREQVEVGGSVKPGVSRTYTKVSVDDWTYNFGPNEFMYRVIFENGKVAQIESLEWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WS9</accession>
    <name>Q39WS9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365769.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1055"/>
    <dbReference type="EnsemblBacteria" id="ABB31295">
        <property type="protein sequence ID" value="ABB31295"/>
        <property type="gene ID" value="Gmet_1055"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1055"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="IVELTHH"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="146"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="508" mass="55883" checksum="9E47138910DB3AF3" modified="2005-11-22" version="1">MSQIKVLIIDDEADVCTFFRRLLTRKGYDVVTASKEPEAMRAIEEHRFTVAMVDLKLPDTDGLTLLQAIKARQPACEVIIMTGYSTIKTAVAAMQLGAYEYLEKPFDDIDEIEALIEKAASHGFNLQQGSAAAEEWAEVARAVGFQVGASLGMRRLVSVAHKIAGKNVTVLIQGSTGTGKEVLARFIHSASGRADQAFIPVNCGALPENLLESELFGHEKGAFTGAAQPRRGIFELANRGTLFLDEIGDASPQIQVKLLRVLETGEFMRVGGEKPIKTDVRVIAATNVDLEQAIREKTFREDLYYRLNVVRLEIPPLRSRSEDIPQLAEHFVRQLNAALRISPPALRLLQGYGWPGNIRQLANVIRRAVVMCSGDTILPEHLESTLLNSAALAGDTFSPVSSQAGEGAVSLSPERLWRTDVSVEELRKLGADELKRMLDSLRALEGRLITAMGEGGGAARRCLKDTEEETIRQALEQYRWNITETAKVLGIGRNTLYRKIKQYGLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WU3</accession>
    <name>Q39WU3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Tungstate ABC transporter, periplasmic tungstate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tupA</name>
        <name evidence="2" type="ordered locus">Gmet_1041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513214.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1041"/>
    <dbReference type="EnsemblBacteria" id="ABB31281">
        <property type="protein sequence ID" value="ABB31281"/>
        <property type="gene ID" value="Gmet_1041"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1041"/>
    <dbReference type="eggNOG" id="COG2998">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061511_0_0_7"/>
    <dbReference type="OMA" id="LADRGTW"/>
    <dbReference type="OrthoDB" id="1567509at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="27"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="269" mass="29179" checksum="1B013A8A0FC2B255" modified="2005-11-22" version="1">MNSLRGIILTLVALVVLCGAASAEERLKMSTTTSTQDSGLLKVLLPPFEKKNNCKVDVIAVGTGQALKLGEAGDVDVVFVHARKLEDKFVADGFGVNRKDVMYNDFVIIGPKNDPAGIAKAKTAAEALKLIAARQATFVSRGDKSGTHMKELELWKAAGTDPKGSWYIEAGQGMGPVITMATERRGYTLADRGTYNAFKGQKTDLAIVFQGEKGLFNPYGIIAVNPKKFPHVKYDLAMKFIDYVTGPEGLKIISGYKAHGEPVFFIYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WW1</accession>
    <name>Q39WW1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Respiratory nitrate reductase, iron-sulfur cluster-binding beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">narH-2</name>
        <name evidence="3" type="ordered locus">Gmet_1021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513192.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1021"/>
    <dbReference type="EnsemblBacteria" id="ABB31263">
        <property type="protein sequence ID" value="ABB31263"/>
        <property type="gene ID" value="Gmet_1021"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1021"/>
    <dbReference type="eggNOG" id="COG1140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_5_2_7"/>
    <dbReference type="OMA" id="TWGANWD"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="208"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="495" mass="55574" checksum="554377737BA1C36D" modified="2005-11-22" version="1">MKVRAQVSMVFNLDKCIGCHTCSIACKNIWSDRRGAEYMWWNNVETKPGTGYPTLWEDQEKYRGGWERTDREPRLRLHSRGGGLAKLFFNPRLPTIDDYYEPWSYRYGDLLSAPAGDDQPVARPVSLVTGDPINIEAGPNWDDDLGGSPVYGAHDPNLAAVSEAERRQLFLLERMVLFYLPRICNHCANPGCVAACPSGAIYKRGEDGIVLVSQEKCRGWRMCVSGCPYKKVYYNWGSGKSEKCILCYPRQETGQAPACFHSCVGRLRYLGVLLYDAERIERSASRPDHDLVQAQREMILDPSDPEVVNKAAEEGIHPAVLAAARNSPVYRFVKEWRLALPLHPEFGTVPMLYYVPPLLPLAADRENGCYDLGGEFFTSLEQGRLPLRYLASLFSAGNEEIIRAVYRKLTAVRVHRRAATTGDVPAGELERFLAEAGTTPEEAEAIYHMTSLAGFDERHAVPPFMREMAMEMSVDPADRKGEAGTGFLRPPKRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WW9</accession>
    <name>Q39WW9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese homology domain superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1013"/>
    <dbReference type="EnsemblBacteria" id="ABB31255">
        <property type="protein sequence ID" value="ABB31255"/>
        <property type="gene ID" value="Gmet_1013"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1013"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2023415_0_0_7"/>
    <dbReference type="OMA" id="STEWVRE"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="50"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="133" mass="15095" checksum="0BD63B3B9A803946" modified="2005-11-22" version="1">MRGGPRRRCLMKYGFEISAAEVKARMNAGEQLFFVNLRHHQDWDLAVMQVRGALRIDDDKVEAHLEEIPRERTVVVYSTCPGDEPSARVARLLQEHGWKDAHSLIGGFEAYCQEGLPVEEIGEGSSVRKIMML</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X41</accession>
    <name>NADK_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD kinase</fullName>
            <ecNumber evidence="1">2.7.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-dependent NAD kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadK</name>
        <name type="ordered locus">Gmet_0941</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NAD(+) = ADP + H(+) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:18629"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514424.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X41"/>
    <dbReference type="SMR" id="Q39X41"/>
    <dbReference type="STRING" id="269799.Gmet_0941"/>
    <dbReference type="EnsemblBacteria" id="ABB31183">
        <property type="protein sequence ID" value="ABB31183"/>
        <property type="gene ID" value="Gmet_0941"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0941"/>
    <dbReference type="eggNOG" id="COG0061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008831_0_1_7"/>
    <dbReference type="OMA" id="VNLGHVG"/>
    <dbReference type="OrthoDB" id="1463423at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000229639" description="NAD kinase">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="66"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="140"/>
            <end position="141"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="181"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00361"/>
        </source>
    </evidence>
    <sequence length="283" mass="31071" checksum="C297788A90E10533" modified="2005-11-22" version="1">MKKIAIFAKVHDPRCQGVAGELITWLEQRRIVPLVEAHFARHLGRSGVTSEEIPDLADMAVVLGGDGTLISAARLLGGREIPILGVNLGSLGFLTEVTLDELYPALEACLGGDYRVSERMMLAATVERGDDIVFSHRVLNDAVINKGALARIVDMESLVNGHYLTTYKADGLIISTPTGSTGYCLSANGPIVHPDLECLTITPICPHTLTNRPIVLEASAEVTIRLISKNEDVYLTLDGQVGMELKCGDIIRVRRAEHRTRLVMSRSKDYFEVLRTKLKWGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X56</accession>
    <name>Q39X56_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Cell shape-determining protein MreC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Cell shape protein MreC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mreC</name>
        <name evidence="6" type="ordered locus">Gmet_0926</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in formation and maintenance of cell shape.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the MreC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513956.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0926"/>
    <dbReference type="EnsemblBacteria" id="ABB31168">
        <property type="protein sequence ID" value="ABB31168"/>
        <property type="gene ID" value="Gmet_0926"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0926"/>
    <dbReference type="eggNOG" id="COG1792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042663_1_0_7"/>
    <dbReference type="OMA" id="NPFTHRI"/>
    <dbReference type="OrthoDB" id="837894at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042177">
        <property type="entry name" value="Cell/Rod_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042175">
        <property type="entry name" value="Cell/Rod_MreC_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007221">
        <property type="entry name" value="MreC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34138">
        <property type="entry name" value="PTHR34138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04085">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038471">
        <property type="entry name" value="MreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00219">
        <property type="entry name" value="mreC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR038471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="273" mass="29644" checksum="E851EDC36BC252D0" modified="2005-11-22" version="1">MLELIRKYRFHLLTGAALLAALAFYSLSLRDREHASGFERMVIDLFAPVHNVGAGVSGFFSGVWNDYIDLVDVRAENKQLRESVKTLNSRLIENREAIHENMRLRQLLDLKAIQRAPSVAAMVIGEDSSPWFKTLVINRGAVDGLQEGMPVVAANGVVGQVIKVAAGSSRVLLLTDTASGIASVVQRSRARGVVKGKGGGLCFLEFSLREEDVKVGDMVVTSGIGGIFPKGLVIGEVTMVRKGEYGIFQTISVRPAVNMARLEEVLVLLQKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X92</accession>
    <name>Q39X92_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA protection single-strand-binding protein DprA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dprA</name>
        <name evidence="3" type="ordered locus">Gmet_0890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DprA/Smf family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513037.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0890"/>
    <dbReference type="EnsemblBacteria" id="ABB31132">
        <property type="protein sequence ID" value="ABB31132"/>
        <property type="gene ID" value="Gmet_0890"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0890"/>
    <dbReference type="eggNOG" id="COG0758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1948">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029601_0_3_7"/>
    <dbReference type="OMA" id="SEMPFGW"/>
    <dbReference type="OrthoDB" id="1881437at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009294">
        <property type="term" value="P:DNA-mediated transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003488">
        <property type="entry name" value="DprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041614">
        <property type="entry name" value="DprA_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43022">
        <property type="entry name" value="PTHR43022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02481">
        <property type="entry name" value="DNA_processg_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17782">
        <property type="entry name" value="DprA_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00732">
        <property type="entry name" value="dprA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DprA_WH" evidence="2">
        <location>
            <begin position="296"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="358" mass="38105" checksum="421228A27DD1746D" modified="2005-11-22" version="1">MDHYHWFALKSVPLVGNVLFRRLLERFGSPEAVFGASDVDLRSVKGVSPAVVASLRSHDPHPFADRECAAVRRTGCRIVTILDDEYPPLLREIADPPPFLYVRGSLAGIGTSVAVVGSRRASAYGRTVTERMAEELARNGVTVISGLARGVDTAAHRGALKGDGTTVGVLGCGVDVVYPAENRQLFREMAEQGAVVSEFPLGTAPLAENFPRRNRIISGISHGVLVVEAAERSGSLVTARIALDQGRDVYAIPGNITSDGSRGANRLIREGAKLVESVEDILEELPGGRVARRGVPAPAPDLPPAEAAVFALLAPEPLHIDEIIAKSALTVGELSAMLLRLELKGAVTQLPGKYFCTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XA6</accession>
    <name>Q39XA6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0876</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513022.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0876"/>
    <dbReference type="EnsemblBacteria" id="ABB31118">
        <property type="protein sequence ID" value="ABB31118"/>
        <property type="gene ID" value="Gmet_0876"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0876"/>
    <dbReference type="eggNOG" id="ENOG5030WK3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033811_1_0_7"/>
    <dbReference type="OMA" id="AVRWEIP"/>
    <dbReference type="OrthoDB" id="568037at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045750">
        <property type="entry name" value="DUF6178"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19676">
        <property type="entry name" value="DUF6178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="396" mass="44917" checksum="1C7C75F73C82CD93" modified="2005-11-22" version="1">MGNNDTIAALRELPAKQRMDLILADPEAKSLARSLPEQELYWLIKEIGETDAMGLWELASPEQRTFILDMELWDKWNFTADKSYEWLGHLLEAGEEVVAEQLPHLDLELLLLMLEKEISVGGGIGELLPDEERTADWDHTFDNLYFITFKNDKHARTVGSFLDIVYRTNHEFYLGIMEGVKSEVEDELEELAFRFRSGRLADLGFPEQEEAQSLYARIDPASFVLEGGKELFPAAVHRHLPVRPGAAESLLGRLLARPGAEEINQELTYLVNSALVVDGTALHDREAMLAIFERVHGYLNIALEFLARNDEEKAAAILAGERLKRLFRLGFSIVMDLAKQARGLTSDDYATGKALRALTATPPRYHRAFDPDGVDGFREFREMADVERVREFLVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XE5</accession>
    <name>Q39XE5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aerobic-type carbon monoxide dehydrogenase, large subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0837</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512981.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0837"/>
    <dbReference type="EnsemblBacteria" id="ABB31079">
        <property type="protein sequence ID" value="ABB31079"/>
        <property type="gene ID" value="Gmet_0837"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0837"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013917_0_0_7"/>
    <dbReference type="OMA" id="TRQWNTP"/>
    <dbReference type="OrthoDB" id="337328at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012368">
        <property type="entry name" value="OxRdtase_Mopterin-bd_su_IorB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036389">
        <property type="entry name" value="IOR_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="2">
        <location>
            <begin position="209"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="724" mass="77422" checksum="0528C6794C23BD4A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XH2</accession>
    <name>Q39XH2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acrB</name>
        <name evidence="5" type="ordered locus">Gmet_0810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cell inner membrane</location>
            <topology evidence="2 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514397.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0810"/>
    <dbReference type="EnsemblBacteria" id="ABB31052">
        <property type="protein sequence ID" value="ABB31052"/>
        <property type="gene ID" value="Gmet_0810"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0810"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_0_1_7"/>
    <dbReference type="OMA" id="LMYMSSS"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="366"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="877"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="901"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="927"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="971"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1004"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1053" mass="114311" checksum="D347560EBB8F24BD" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XL6</accession>
    <name>Q39XL6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0766</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365721.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0766"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="DNASU" id="3739329"/>
    <dbReference type="EnsemblBacteria" id="ABB31008">
        <property type="protein sequence ID" value="ABB31008"/>
        <property type="gene ID" value="Gmet_0766"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0766"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_7_0_7"/>
    <dbReference type="OMA" id="FEGGMAN"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="46"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="156"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="339" mass="37177" checksum="47F9574429F1A14F" modified="2005-11-22" version="1">MKIALITPYYAPPVRGNAVTVRRIAAHLATAGCEAAVYSLDCLTAAQILEEIRQMKPDAIHGFHAYLGGRVAREIARVVGIPYIVTLTGSDVYEALADDRREESLAVLRDATAIVAFDPSVKHRVVDHHPSLAAKTRIIPQGVELPGEIFCWGEERFDAGEIVFFLPAGLRPVKNVGFPLATMAELHGEDSRVRLVAAGPVLDETYGATVLAEMVRHPFARYLGEVGHDAIGAIYRRADVVLNTSIFEGGMANSVLEAMAFGRPVLAADIEGNRSIVKEGKTGLLYRDEGELLQKARDLLQDDGLRRRLGEQGRRFVEERFSAGREAEAYRELYGWVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XQ3</accession>
    <name>Q39XQ3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="synonym">sucC-1</name>
        <name evidence="9" type="ordered locus">Gmet_0729</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514446.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0729"/>
    <dbReference type="EnsemblBacteria" id="ABB30971">
        <property type="protein sequence ID" value="ABB30971"/>
        <property type="gene ID" value="Gmet_0729"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0729"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_7"/>
    <dbReference type="OMA" id="AIQQFKV"/>
    <dbReference type="OrthoDB" id="316012at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="320"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="52"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="385" mass="41913" checksum="49E5FB06C2E48560" modified="2005-11-22" version="1">MNIHEYQAKEILSSYSIPVPRGRVALTSDQVERAAKEMGGRCVIKAQIYAGGRGKAGGVKLVHHPEQAQDYGKELFGKRLVTPQTGPEGLKVRRILVEEAVEIAREFYLSITLDRATSRYCLIASAEGGVDIEEVAQKSPEKIHVLTIDPYTGLRPYLARKIALALGLTGSLCEDCVELMLNLYKVVLDKDCSLVEINPLVVTRAGWLMAMDAKINFDDNAVFRHREYPDMMDYSQLDTLEINAGKYDLSYIKLSGNIGCMVNGAGLAMATLDVLKEYGGEPANFLDVGGGATREKVAEAFKIILEDADVKGVFVNIFGGIMRCDVIAQGIIEAASEVHCTLPIVVRMDGSKVLEGKQLLVDSGLNVQTADSLGEGAERIVQMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XS3</accession>
    <name>Q39XS3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514614.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0709"/>
    <dbReference type="EnsemblBacteria" id="ABB30951">
        <property type="protein sequence ID" value="ABB30951"/>
        <property type="gene ID" value="Gmet_0709"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0709"/>
    <dbReference type="eggNOG" id="ENOG5033239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111078_0_0_7"/>
    <dbReference type="OMA" id="IYESRHN"/>
    <dbReference type="OrthoDB" id="1872334at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021279">
        <property type="entry name" value="DUF2721"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11026">
        <property type="entry name" value="DUF2721"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="175" mass="19273" checksum="76A634FC6EB30FE6" modified="2005-11-22" version="1">MALQDKELLEALASTKILTSMITPAVLISAAGTLIFSTSNRLGRIFDRVNSLKSELEAVLAGKLSHAEERLAVIRTQVEIQHVRAGLMQKALSALYTATAFFIAASLAIAFNVAYGSFATSWIPTALALAGGLFLFAASALLLYESRYNLTFINRHIRFIKYLEDRHEEERGKHT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XY9</accession>
    <name>RS5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsE</name>
        <name type="ordered locus">Gmet_0643</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With S4 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.</text>
    </comment>
    <comment type="domain">
        <text>The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514253.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XY9"/>
    <dbReference type="SMR" id="Q39XY9"/>
    <dbReference type="STRING" id="269799.Gmet_0643"/>
    <dbReference type="EnsemblBacteria" id="ABB30885">
        <property type="protein sequence ID" value="ABB30885"/>
        <property type="gene ID" value="Gmet_0643"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0643"/>
    <dbReference type="eggNOG" id="COG0098">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065898_2_2_7"/>
    <dbReference type="OMA" id="KRGCGSW"/>
    <dbReference type="OrthoDB" id="1505038at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01307_B">
        <property type="entry name" value="Ribosomal_S5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_S5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005712">
        <property type="entry name" value="Ribosomal_S5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_S5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_S5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_S5_N_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="PTHR13718"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01021">
        <property type="entry name" value="rpsE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000230346" description="30S ribosomal protein S5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="S5 DRBM" evidence="1">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01307"/>
        </source>
    </evidence>
    <sequence length="162" mass="17039" checksum="5B0A6F830CB7C380" modified="2005-11-22" version="1">MQKINPNELNLTDKVVHISRVAKVVKGGRRFSFSALVVVGDGSGFVGYGLGKANEVPEAIRKGVEQAKKNLIKVPIVEGQTIPYEVLGHFGAGRVLIKPASAGTGVIAGGAARAVFESAGLHNVLSKCLGSNNPHNVVKAAFDGLKQLRSPDEIMARRGMAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y06</accession>
    <name>RL3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplC</name>
        <name type="ordered locus">Gmet_0626</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365699.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y06"/>
    <dbReference type="SMR" id="Q39Y06"/>
    <dbReference type="STRING" id="269799.Gmet_0626"/>
    <dbReference type="EnsemblBacteria" id="ABB30868">
        <property type="protein sequence ID" value="ABB30868"/>
        <property type="gene ID" value="Gmet_0626"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0626"/>
    <dbReference type="eggNOG" id="COG0087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044142_4_1_7"/>
    <dbReference type="OMA" id="KRMAGRY"/>
    <dbReference type="OrthoDB" id="1270636at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01325_B">
        <property type="entry name" value="Ribosomal_L3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_L3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019927">
        <property type="entry name" value="Ribosomal_L3_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_L3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11229">
        <property type="entry name" value="PTHR11229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03625">
        <property type="entry name" value="L3_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000241349" description="50S ribosomal protein L3">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01325"/>
        </source>
    </evidence>
    <sequence length="210" mass="22692" checksum="8871D90DE4FAED80" modified="2005-11-22" version="1">MKKGLIAKKLGMTQIFADDGRRIPVTVVEAGPCIVLQKKTVETDGYNAIQVGFLAKDADKSGRALVGHCKSAGQGVFTYIREFRVEDVDRYTIGDSITAEIFAPGDYVDVTGTSIGKGFQGVIKRWGFRGGRSSHGSCFHRAPGSIGSSAWPSRVFKNKKMPGQLGNERVTVQRLQVVRVDTADNLLLIRGAIPGAKNGILLLKDSVKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y42</accession>
    <name>Q39Y42_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-mannose--undecaprenyl-phosphate mannosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512287.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0589"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30832">
        <property type="protein sequence ID" value="ABB30832"/>
        <property type="gene ID" value="Gmet_0589"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0589"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_1_7"/>
    <dbReference type="OMA" id="HRILFFW"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="226" mass="25244" checksum="9015A0A2EE468A1F" modified="2005-11-22" version="1">MKLSVVMPVYNEKATLRAIYEQVAAVTIDKEIILVDDCSTDGTREIVRELGATGATVVLHDRNMGKGAALRSGFRHVTGDVVLIQDADLEYDPGQYPLLIQPILNGEVDVVYGSRFLSGERSLGMSFWNRAGNRILTYLSNTLTKLELTDVETCYKVFSRDVLERITIEENRFGCEPEITAKLAKLGVRIREVGISYRGRTSAEGKKIGWRDFISSVRCIAKYTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y45</accession>
    <name>Q39Y45_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0586</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512284.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0586"/>
    <dbReference type="EnsemblBacteria" id="ABB30829">
        <property type="protein sequence ID" value="ABB30829"/>
        <property type="gene ID" value="Gmet_0586"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0586"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_5_7"/>
    <dbReference type="OMA" id="PCEAYQT"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="28"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="SPASM" evidence="7">
        <location>
            <begin position="270"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="350" mass="39488" checksum="1427BC3D0A88FCC1" modified="2005-11-22" version="1">MRFPRLAYRVLRSNLGDLPEPYRMTWGVTSRCQARCAMCNIWRRPAGDELSLSEIDRFLARSNRFSWINLTGGEIFLRDDIDGILDVIDRHCRQLCLLNFPTNGHDSDRIVAVVRAFLARMSVPRLMVSVSLDGPPELHDRIRGVDGSWERAVATFRRLRELRSRRFSVFLGYTVQEANLDGFDGMLQAVRREVEVTDDELHVNVAHVSGLYYDNATFSGLPAPEETCRLLDRISASRRSGVMSPVSFLERRYQSLVRPYLERGTTPLACQAAAASCYVDPGGTVYPCTGFDAPVGSLREWGYDLGRLWRSPRRHEVRQAVRDGACPGCWTPCEAYQTIMANLFAGGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y61</accession>
    <name>Q39Y61_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512267.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0570"/>
    <dbReference type="EnsemblBacteria" id="ABB30813">
        <property type="protein sequence ID" value="ABB30813"/>
        <property type="gene ID" value="Gmet_0570"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0570"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064908_0_0_7"/>
    <dbReference type="OMA" id="FLGCPWR"/>
    <dbReference type="OrthoDB" id="1104816at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026366">
        <property type="entry name" value="Seleno_YedE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04112">
        <property type="entry name" value="seleno_YedE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="209"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="353" mass="36437" checksum="C7796782515941BA" modified="2005-11-22" version="1">MLRDRHFWMVVAAGLLLGGLGALLAVWGNPENSGICVSCFIENSAGALGMHDNPRMQYLRPELIGFVLGAMASALLFREFRSRGGSAPLPRLFAGIFLMVGCGVFIGCPIKLFLRLTAGDLTAVAGVAGLVAGVWAGLRGLANGVEPGQTSRGQGHGGPLIPAFFILLLVFLLIRPGFILFSTQGSAAQHAPVPLALGAGVVLGALAQRSRFCITGSIRDVFLMGKRTPALWGMLAFLAAAVAANLATGRFNPGLHGQPGAHLEHLWSFLGMGLTGWISVLIGGCPFRQLIKAGEGDADAGLVVVGMFIGGALVQSWGIAATAAGVSLTGKVAILAGFASVLAASLLFRSRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YC0</accession>
    <name>Q39YC0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Molybdopterin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512207.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0511"/>
    <dbReference type="EnsemblBacteria" id="ABB30754">
        <property type="protein sequence ID" value="ABB30754"/>
        <property type="gene ID" value="Gmet_0511"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0511"/>
    <dbReference type="eggNOG" id="COG3585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118993_0_1_7"/>
    <dbReference type="OMA" id="CGLNFSA"/>
    <dbReference type="OrthoDB" id="1582630at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00638">
        <property type="entry name" value="Mop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="3">
        <location>
            <begin position="74"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="141" mass="14104" checksum="4069D457DE882942" modified="2005-11-22" version="1">MKLSARNVLLGTVSGITKGAVNAEVSLTLKAGTPVIAVVTNASVDNLGLAVGKEAHVIVKASSIIIGTDLHDAKVSARNIICGTVVKVIEGPVSAEVDVEIGGGNTLSAVITHESARNLGIKEGGHACALFKASSVILGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YK7</accession>
    <name>Q39YK7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512396.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0424"/>
    <dbReference type="EnsemblBacteria" id="ABB30667">
        <property type="protein sequence ID" value="ABB30667"/>
        <property type="gene ID" value="Gmet_0424"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0424"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2450401_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="89" mass="10229" checksum="850AF9EDD6654CF6" modified="2005-11-22" version="1">MAIRQEQYEKIKELAQSYGATRIILFRSAVDNPEAARDIDIACDGVRGWKLYELAARLEEELHTPFDVVPLTPPTRFTELVEKRGRVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YL5</accession>
    <name>Q39YL5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Cell division protein FtsA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ftsA</name>
        <name evidence="8" type="ordered locus">Gmet_0416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Self-interacts. Interacts with FtsZ.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="5">Localizes to the Z ring in an FtsZ-dependent manner. Targeted to the membrane through a conserved C-terminal amphipathic helix.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512388.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0416"/>
    <dbReference type="EnsemblBacteria" id="ABB30659">
        <property type="protein sequence ID" value="ABB30659"/>
        <property type="gene ID" value="Gmet_0416"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0416"/>
    <dbReference type="eggNOG" id="COG0849">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037850_3_2_7"/>
    <dbReference type="OMA" id="DGIIRHT"/>
    <dbReference type="OrthoDB" id="1044637at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02033">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020823">
        <property type="entry name" value="Cell_div_FtsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02491">
        <property type="entry name" value="SHS2_FTSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003101">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01174">
        <property type="entry name" value="ftsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 5 6" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="7">
        <location>
            <begin position="9"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR003101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="411" mass="43900" checksum="E7D47709519E63AB" modified="2005-11-22" version="1">MSARRDNLIVGLDIGTTKICAIVGNVTEDGIDIVGIGSSPSRGMRKGVVINIESTVESIKKAVSEAELMAGCEIRSVYAGIAGGHIKGFNSQGVIAIKNREVTSEDVKRVIDAAKAIAIPMDREVIHILPQEFIIDDQDGIREPLGMSGVRLEAKVHIVTGAVASAQNIVKACNRAGLDVADIVLEQLASSEAVLSADEKELGVALVDIGGGTTDIAIFVDGAIKHTSVLSLGGNHLTNDIAVGLRTPMAEAEKIKQKYGCCMASLVGKEETIEVPSVGGRKPRVLSRQLLAEILEPRVEEIFTLVNREIMKSGFEDLIASGVVITGGTTILEGMPELAEQVFNLPVRRGMPQQIGGLVDVVNSPVYATGVGLVVYGSKNVGIREFPTAQTDENLFRRVSRRMKEWFGEFF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-29" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YS9</accession>
    <name>LSPA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoprotein signal peptidase</fullName>
            <ecNumber evidence="1">3.4.23.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolipoprotein signal peptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Signal peptidase II</fullName>
            <shortName evidence="1">SPase II</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lspA</name>
        <name type="ordered locus">Gmet_0352</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein specifically catalyzes the removal of signal peptides from prolipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains.</text>
            <dbReference type="EC" id="3.4.23.36"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (signal peptide cleavage).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A8 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.23.36" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512323.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YS9"/>
    <dbReference type="SMR" id="Q39YS9"/>
    <dbReference type="STRING" id="269799.Gmet_0352"/>
    <dbReference type="EnsemblBacteria" id="ABB30595">
        <property type="protein sequence ID" value="ABB30595"/>
        <property type="gene ID" value="Gmet_0352"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0352"/>
    <dbReference type="eggNOG" id="COG0597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083252_4_0_7"/>
    <dbReference type="OMA" id="NRWYFPA"/>
    <dbReference type="OrthoDB" id="1575081at2"/>
    <dbReference type="UniPathway" id="UPA00665"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00161">
        <property type="entry name" value="LspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001872">
        <property type="entry name" value="Peptidase_A8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33695">
        <property type="entry name" value="PTHR33695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01252">
        <property type="entry name" value="Peptidase_A8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00781">
        <property type="entry name" value="LIPOSIGPTASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00077">
        <property type="entry name" value="lspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00855">
        <property type="entry name" value="SPASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0064">Aspartyl protease</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000289386" description="Lipoprotein signal peptidase">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00161"/>
        </source>
    </evidence>
    <sequence length="162" mass="18288" checksum="7E11780DCFD65DA0" modified="2005-11-22" version="1">MKPNYRIFSIVTAVSLVIDQATKILVDRTLELYQSIPVVPGLFSITYMRNKGAAFSFLSNFDYRRPFFIAVTLVAMAAIAITFRKLRDDQRLAAVSLSLIFSGAVGNLIDRVRLGEVIDFLDVYWKTHHWPAFNVADSAICVGVALLALDMIRDERRQSKDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YU7</accession>
    <name>Q39YU7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nitrate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">narT</name>
        <name evidence="7" type="ordered locus">Gmet_0334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512306.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0334"/>
    <dbReference type="EnsemblBacteria" id="ABB30577">
        <property type="protein sequence ID" value="ABB30577"/>
        <property type="gene ID" value="Gmet_0334"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0334"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033198_1_0_7"/>
    <dbReference type="OMA" id="WWYYARR"/>
    <dbReference type="OrthoDB" id="1217595at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015113">
        <property type="term" value="F:nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17341">
        <property type="entry name" value="MFS_NRT2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004737">
        <property type="entry name" value="NO3_transporter_NarK/NarU-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00886">
        <property type="entry name" value="2A0108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="475" mass="51230" checksum="66D9FB8FD606AB9A" modified="2005-11-22" version="1">MPTDVLTATETKKSASSHVLTEWTPEDQHFWETRGKAIATRNLWISIPALFLAFAVWMVWSVVCVNLPNIGFKYDTNKLFWLTALPALAGATLRIFYSFMVPIFGGRRWTAISTASLLIPAMGIGFAVRDPATSYSTMLILAVLCGFGGGNFASSMANISFFYPKALKGTALGLNAGLGNLGVSAMQFLVPLVISTGMFAALCGDPQQCVINGVTKPMWLQNAGFVWVPFIALSALVAWFGMNDIASAKASFSDQAIIFRRKHNWLMCILYLGTFGSFIGYSAGLPLLTKSQFPGINPVKYAFLGPLVGALIRPVGGWLADKLGGARVTFWNFIIMAGAVFGVLAFLPHGGVGGNFWGFLAMFILLFATTGIGNGSTFRMIPVIFLTERQRDAAGRGKEAEEQAIKDANKEAAAVLGFTSAFAAYGGFFIPKSFGTSIAATGGPQVALYGFIAFYASCIILTWWYYSRKNAEVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YX6</accession>
    <name>Q39YX6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514015.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30548">
        <property type="protein sequence ID" value="ABB30548"/>
        <property type="gene ID" value="Gmet_0303"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0303"/>
    <dbReference type="HOGENOM" id="CLU_1747021_0_0_7"/>
    <dbReference type="OrthoDB" id="1690571at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="146" mass="16121" checksum="330FEA3AF672A2A6" modified="2005-11-22" version="1">MNVTAIDEAIDKYVHERMMNKGKQPAATRFLSYAYLKYGGDDLAEFMKKVEGLLCYYIDYLKVMGNPLKGPELAWFLSMLTVGAASCYLMNSEELRPAGIAVFVGTLVHAGSLLCHAARKWCEAGVMIAIYREILEIAEGEAKGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YX9</accession>
    <name>Q39YX9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Molybdenum cofactor guanylyltransferase</fullName>
            <shortName evidence="4">MoCo guanylyltransferase</shortName>
            <ecNumber evidence="4">2.7.7.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GTP:molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Mo-MPT guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Molybdopterin-guanine dinucleotide synthase</fullName>
            <shortName evidence="4">MGD synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mobA</name>
        <name evidence="7" type="ordered locus">Gmet_0300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30545.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365649.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0300"/>
    <dbReference type="DNASU" id="3739587"/>
    <dbReference type="EnsemblBacteria" id="ABB30545">
        <property type="protein sequence ID" value="ABB30545"/>
        <property type="gene ID" value="Gmet_0300"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0300"/>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055597_0_1_7"/>
    <dbReference type="OMA" id="KHSHHNV"/>
    <dbReference type="OrthoDB" id="2019898at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004435">
        <property type="entry name" value="MobB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03205">
        <property type="entry name" value="MobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00176">
        <property type="entry name" value="mobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 4" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="6">
        <location>
            <begin position="11"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="MobB" evidence="5">
        <location>
            <begin position="206"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30545.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="371" mass="40595" checksum="EE67D471B7C7E156" modified="2012-10-31" version="2">MDIRPLSDVAGVILVGGRSRRMGRDKALIPLGGKPLVERVIDAFRPLFERILLVGDRGERFASYGLPVFPDIHPGSALGGLYTGLVRAGTPHVFVSACDVPWPDPRVIARLCSLREGFDVVVPRTVGGSEPLFAVYGTGCLPAMERMLREGNYRIYDFYPEVRTRYVEQAELADLVTPARTFVNVNTPEEFETIRNREEGMAIKAVSFVAKSGTGKTTLLEKVIAELKGRGYRIGVIKHDAHRFDIDHPGKDSHRLAAAGADTMLIASPEKLALVKKYDESPPLDELLATYFGDVDIVLTEGFKKSSLPKIEVHRMERSATLLCRGEEHDPTLVAVASDAALALDVPVFDLNNPAQVADFVERTFLAAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z02</accession>
    <name>Q39Z02_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0277"/>
    <dbReference type="EnsemblBacteria" id="ABB30522">
        <property type="protein sequence ID" value="ABB30522"/>
        <property type="gene ID" value="Gmet_0277"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0277"/>
    <dbReference type="HOGENOM" id="CLU_2194501_0_0_7"/>
    <dbReference type="OMA" id="HETASWE"/>
    <dbReference type="OrthoDB" id="2004898at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="109" mass="12492" checksum="397442DE6E7CE88B" modified="2005-11-22" version="1">MTFMALADTEKHDLRVIVEGFWGKHETASWEMNEELVAVLPKMISEVKSCSQAMDFVPRPGVYLNPKDVQRELRKMARRVKEKGTSYWVCMLMGATNWKTEAARVAQGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z77</accession>
    <name>SYA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="1">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">alaS</name>
        <name type="ordered locus">Gmet_0201</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512790.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z77"/>
    <dbReference type="SMR" id="Q39Z77"/>
    <dbReference type="STRING" id="269799.Gmet_0201"/>
    <dbReference type="EnsemblBacteria" id="ABB30447">
        <property type="protein sequence ID" value="ABB30447"/>
        <property type="gene ID" value="Gmet_0201"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0201"/>
    <dbReference type="eggNOG" id="COG0013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004485_1_1_7"/>
    <dbReference type="OMA" id="YHHTMFE"/>
    <dbReference type="OrthoDB" id="91428at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="SSF101353"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000347621" description="Alanine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="568"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="572"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="670"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00036"/>
        </source>
    </evidence>
    <sequence length="876" mass="96364" checksum="0B7591932731BC27" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZC1</accession>
    <name>Q39ZC1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512743.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0156"/>
    <dbReference type="EnsemblBacteria" id="ABB30403">
        <property type="protein sequence ID" value="ABB30403"/>
        <property type="gene ID" value="Gmet_0156"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0156"/>
    <dbReference type="eggNOG" id="COG3189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137928_0_0_7"/>
    <dbReference type="OMA" id="AHPEHWW"/>
    <dbReference type="OrthoDB" id="1831995at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="112" mass="13262" checksum="12BC306BEF26E1B1" modified="2005-11-22" version="1">MLRIKRIYDPPAPEDGTRVLVDRLWPRGISKDEARIDEWLKEIAPSDELRKWFGHDPARWEEFRERFRRELEAKAEILDHLRTLVGKGTVTLLFAAKDEEHNNAVVLKEMLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZI6</accession>
    <name>Q39ZI6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pcrA</name>
        <name evidence="10" type="ordered locus">Gmet_0089</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514746.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0089"/>
    <dbReference type="EnsemblBacteria" id="ABB30338">
        <property type="protein sequence ID" value="ABB30338"/>
        <property type="gene ID" value="Gmet_0089"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0089"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_7"/>
    <dbReference type="OMA" id="APIQTFH"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="8">
        <location>
            <begin position="5"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="9">
        <location>
            <begin position="282"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="487"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="742" mass="83302" checksum="BE96E7282EA4FEFA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZK8</accession>
    <name>Q39ZK8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10 11">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="7 10 11">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">rpe</name>
        <name evidence="15" type="ordered locus">Gmet_0067</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10 13">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 10 11">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="7 10 11"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514191.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0067"/>
    <dbReference type="EnsemblBacteria" id="ABB30316">
        <property type="protein sequence ID" value="ABB30316"/>
        <property type="gene ID" value="Gmet_0067"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0067"/>
    <dbReference type="eggNOG" id="COG0036">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054856_2_1_7"/>
    <dbReference type="OMA" id="WLQVDGG"/>
    <dbReference type="OrthoDB" id="1697639at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="PTHR11749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01163">
        <property type="entry name" value="rpe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10 14">
        <location>
            <begin position="196"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10 12">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10 12">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 14">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 13 14">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10 13">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB30316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="221" mass="23894" checksum="0C725D06FB65437B" modified="2005-11-22" version="1">MKKIAPSILSADFSRLGDEVRAVAAAGADYIHVDVMDGHFVPNITIGPPVVEAVRKVTELPLDVHLMIENPDRYIPDFAKAGSDIIVVHAEASVHLHRTIQLIKSLGKKAGVSLNPATPLSVLEYVLDELDLVLLMTVNPGFGGQSFIEACLPKIQALRAMLDRRGCNAELEVDGGVKIDNIDRIAHAGANVFVAGSAVFGSKDYKETIKELKRRAKEPIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZS1</accession>
    <name>RECF_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA replication and repair protein RecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recF</name>
        <name type="ordered locus">Gmet_0003</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513722.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZS1"/>
    <dbReference type="SMR" id="Q39ZS1"/>
    <dbReference type="STRING" id="269799.Gmet_0003"/>
    <dbReference type="EnsemblBacteria" id="ABB30253">
        <property type="protein sequence ID" value="ABB30253"/>
        <property type="gene ID" value="Gmet_0003"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0003"/>
    <dbReference type="eggNOG" id="COG1195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040267_0_1_7"/>
    <dbReference type="OMA" id="GESWSYA"/>
    <dbReference type="OrthoDB" id="891841at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00365">
        <property type="entry name" value="RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018078">
        <property type="entry name" value="DNA-binding_RecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042174">
        <property type="entry name" value="RecF_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00611">
        <property type="entry name" value="recf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00618">
        <property type="entry name" value="RECF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000236119" description="DNA replication and repair protein RecF">
        <location>
            <begin position="1"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00365"/>
        </source>
    </evidence>
    <sequence length="365" mass="41043" checksum="77A77161751B1DFC" modified="2005-11-22" version="1">MFVTKIQISSFRNIAAAEIRFDRRFNVLHGANGQGKTSVLEAIYLLGTMKSFRLAKTPDLVSWNTPHALLRGWAERDGVGREIALYLGKEGRKARVDQKPVTRLADFFGNVNAVVFSPEEIAMARSGPDLRRRYLDRAIFSGDLGYLLLHHEYHRLLKQRNALLKRGSREGLDIWTGQLAEAGTRLMVKRMGYLAEIEPLVQRFYREIAGGEEEAGLAYRPHLTTPDLVSREGTDALLALFGAHEAEELRRGTTVVGPHRDDVDFVLNGRVIRTHGSQGQQRSFVLALKMAEIEYLERLNDAPPVLLLDDISSELDPQRNANLMTFLREKRMQVFITTTDVSTLRLAGIATHASFHVSRGTVTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>J7LW60</accession>
    <name>J7LW60_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514173.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0049"/>
    <dbReference type="EnsemblBacteria" id="AFR42785">
        <property type="protein sequence ID" value="AFR42785"/>
        <property type="gene ID" value="Gmet_0049"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0049"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1822582_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFR42785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="141" mass="14805" checksum="94AF827E34E32056" modified="2012-10-31" version="1">MTGLYNRRFFEAEMDRIDRGRHFPASVIMVDVDRLKWLVGACCRRPADRHGGPGDPGGVSGRGRGGAGGGDEFAVILEGTDGAASAEALVRLRGSVAALNGGSAECGLSLSLGAATTDAPGTLRDAWRLADRRMYEDKVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>J7M085</accession>
    <name>J7M085_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3592"/>
    <dbReference type="EnsemblBacteria" id="AFR42807">
        <property type="protein sequence ID" value="AFR42807"/>
        <property type="gene ID" value="Gmet_3592"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3592"/>
    <dbReference type="HOGENOM" id="CLU_2972994_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="58" mass="6357" checksum="0EF6E307F4914CAF" modified="2012-10-31" version="1">MTNVPDLFSLAKVMGIIIVLVLFPPLPLSTIPERNLSLSNNRLNSHSVCVNVASFLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEN8</accession>
    <name>J9JEN8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3618</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3618"/>
    <dbReference type="EnsemblBacteria" id="AFR42836">
        <property type="protein sequence ID" value="AFR42836"/>
        <property type="gene ID" value="Gmet_3618"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3618"/>
    <dbReference type="HOGENOM" id="CLU_2861371_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="64" mass="7476" checksum="11630798C7794EA4" modified="2012-10-31" version="1">MSSVHYLGDHIEEGEIEIARQIVEIAKAGQYDGAERQVKRPRSRFKPGEKYGVESRWGKMFHMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEN9</accession>
    <name>J9JEN9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511810.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3621"/>
    <dbReference type="EnsemblBacteria" id="AFR42839">
        <property type="protein sequence ID" value="AFR42839"/>
        <property type="gene ID" value="Gmet_3621"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3621"/>
    <dbReference type="HOGENOM" id="CLU_2752079_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="70" mass="7522" checksum="D2DB038971EA1F9F" modified="2012-10-31" version="1">MNPEWLVPYLLVALLVFLMPKIFGMLGKGKSTASGKPAFVPHYIYVLTGIIVAGILLYTAAKVIITVVCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PQ2</accession>
    <name>Q39PQ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase of ISGme2, IS4 family</fullName>
        </submittedName>
        <submittedName>
            <fullName evidence="4">Transposase of ISGme2, IS5 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2093</name>
        <name evidence="4" type="ordered locus">Gmet_A3567</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5">
        <name>pGS-15</name>
    </geneLocation>
    <geneLocation type="plasmid" evidence="4">
        <name>unnamed</name>
    </geneLocation>
    <reference evidence="3 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="4">GS-15</strain>
            <strain evidence="4">unnamed</strain>
            <plasmid evidence="5">pGS-15</plasmid>
            <plasmid evidence="4">unnamed</plasmid>
        </source>
    </reference>
    <reference evidence="4 5" key="3">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="4">GS-15</strain>
            <plasmid evidence="5">pGS-15</plasmid>
            <plasmid evidence="4">unnamed</plasmid>
        </source>
    </reference>
    <reference evidence="3" key="4">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011363043.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2093"/>
    <dbReference type="DNASU" id="3738018"/>
    <dbReference type="EnsemblBacteria" id="ABB32322">
        <property type="protein sequence ID" value="ABB32322"/>
        <property type="gene ID" value="Gmet_2093"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33772">
        <property type="protein sequence ID" value="ABB33772"/>
        <property type="gene ID" value="Gmet_A3567"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2093"/>
    <dbReference type="KEGG" id="gme:Gmet_A3567"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043140_0_0_7"/>
    <dbReference type="OMA" id="ANEKRDW"/>
    <dbReference type="OrthoDB" id="1254910at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025399">
        <property type="entry name" value="DUF4372"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14294">
        <property type="entry name" value="DUF4372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4372" evidence="2">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="124"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="389" mass="45350" checksum="19516DF541727CB3" modified="2005-11-22" version="1">MHTGPTVFKQLLQFLPRYEFNLCVRRHRGEYREKKFSTYDQFLCLAYAQMAGRESLRDIETCLNSHQEKLYHIGFRGDVSRTTLADANERRDWRIFQDFGHVLIGIAQQLYQADAISVELTQPLYAFDSTTIDLCLTLFPWAEFRKTKAAVKMHTLIDLRGPIPTWVTITTGKVHDVRMLDHLPVAKDAIYTMDRGYVDFARLHSIHKQGAFFVVRAKDNLKCQRLYSHPKDKESGVRADQIITLVTQKSKKGYPEKLRRVSYVDKERNKRLVFLTNNFEIPAATVAAIYKQRWQVELFFKWIKQHLRIKSFIGTSVNAVKSQIWVALCIYLLVAITKKKLGVPCSLYTFLQILEVNLFEKKPISSLVAEALKRNADYPERNQLNLFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PU3</accession>
    <name>Q39PU3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3526</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513683.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3526"/>
    <dbReference type="EnsemblBacteria" id="ABB33731">
        <property type="protein sequence ID" value="ABB33731"/>
        <property type="gene ID" value="Gmet_3526"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3526"/>
    <dbReference type="eggNOG" id="COG4765">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120406_0_0_7"/>
    <dbReference type="OMA" id="PTTHAFQ"/>
    <dbReference type="OrthoDB" id="1991299at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019225">
        <property type="entry name" value="DUF2155"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09923">
        <property type="entry name" value="DUF2155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223244" evidence="1">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="163" mass="17419" checksum="C42A72BC71D19D7D" modified="2005-11-22" version="1">MGSVFRLFVVVAMVMAAVAGCSKKEEAKPEGMASPHGEAATKKKESVVVVPESVKGKWKAVKIAVTDKAVNKEAVYTVNIGSQLAIPGSGLTIAVDTFLPQFTMDGTTLTSQSNEPKNPAAQIRIIEGGKEVFKGWLFSLYPTTHSFSHPKYGFTLVDFIPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PW5</accession>
    <name>Q39PW5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain iron-sulfur cluster-binding oxidoreductase with cobalamin-binding-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513660.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3504"/>
    <dbReference type="EnsemblBacteria" id="ABB33709">
        <property type="protein sequence ID" value="ABB33709"/>
        <property type="gene ID" value="Gmet_3504"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3504"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_3_7"/>
    <dbReference type="OMA" id="EAGCESM"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="195"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="677" mass="75482" checksum="54166D97172769AA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PY0</accession>
    <name>Q39PY0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, large subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513646.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3489"/>
    <dbReference type="EnsemblBacteria" id="ABB33694">
        <property type="protein sequence ID" value="ABB33694"/>
        <property type="gene ID" value="Gmet_3489"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3489"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013917_0_1_7"/>
    <dbReference type="OMA" id="AVDCGPQ"/>
    <dbReference type="OrthoDB" id="337328at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012368">
        <property type="entry name" value="OxRdtase_Mopterin-bd_su_IorB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036389">
        <property type="entry name" value="IOR_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="203"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="746" mass="80392" checksum="323CDDCB7D2A9BD3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PZ3</accession>
    <name>Q39PZ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response receiver type II secretion system ATPase and double zinc ribbon protein, PulE and DZR domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3473</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513923.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3473"/>
    <dbReference type="EnsemblBacteria" id="ABB33681">
        <property type="protein sequence ID" value="ABB33681"/>
        <property type="gene ID" value="Gmet_3473"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3473"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_10_0_7"/>
    <dbReference type="OMA" id="PVIRIVN"/>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="40"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="823" mass="91479" checksum="D8B740B0C9B27CAE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q73</accession>
    <name>Q39Q73_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonuclease D, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512615.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3389"/>
    <dbReference type="EnsemblBacteria" id="ABB33601">
        <property type="protein sequence ID" value="ABB33601"/>
        <property type="gene ID" value="Gmet_3389"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3389"/>
    <dbReference type="eggNOG" id="COG0349">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042387_3_1_7"/>
    <dbReference type="OMA" id="FMRVDTF"/>
    <dbReference type="OrthoDB" id="1462689at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="SSF47819"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="215"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="2">
        <location>
            <begin position="308"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="382" mass="43177" checksum="86CA0DF3B969C446" modified="2005-11-22" version="1">MPVQPVSPEIITTPDGVRRLADRLSREPYVACDLEADSMHHYQEKVCLIQFTVPGLAAIVDPLAVADLAPLAPVFANPSIRKVFHGADYDIRSLHRDFGIEVNNLFDTMIACQFLGEREFGLAAVLRKRFGVELDKQYQRADWSRRPLTAGMIEYAAKDTTLLIELCGRLEAELREKGRIGWVEEECALLARVRVAQRSDGEPMFLRFKGASRMASRSLAVLEEILCFRDRRAQQMDVPPFKVLGTETVRELAEKKPRSLAELTGITGITERVVERCGEGIVRAVEKGLAVPEQELPFFPREERRKVGGDEERRIKALKGWREDKARRFAVEPGFLANNALLEQIALVFPRSEVELEGIAGLRPWQRREFGAEMVAALQARR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q76</accession>
    <name>PRMA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal protein L11 methyltransferase</fullName>
            <shortName evidence="1">L11 Mtase</shortName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prmA</name>
        <name type="ordered locus">Gmet_3386</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Methylates ribosomal protein L11.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl-[protein] + 3 S-adenosyl-L-methionine = 3 H(+) + N(6),N(6),N(6)-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:54192"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:13826"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. PrmA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512612.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Q76"/>
    <dbReference type="SMR" id="Q39Q76"/>
    <dbReference type="STRING" id="269799.Gmet_3386"/>
    <dbReference type="DNASU" id="3740701"/>
    <dbReference type="EnsemblBacteria" id="ABB33598">
        <property type="protein sequence ID" value="ABB33598"/>
        <property type="gene ID" value="Gmet_3386"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3386"/>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049382_0_1_7"/>
    <dbReference type="OMA" id="EFFFIFP"/>
    <dbReference type="OrthoDB" id="1712450at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00735">
        <property type="entry name" value="Methyltr_PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004498">
        <property type="entry name" value="Ribosomal_PrmA_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000401">
        <property type="entry name" value="RPL11_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00406">
        <property type="entry name" value="prmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000046025" description="Ribosomal protein L11 methyltransferase">
        <location>
            <begin position="1"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00735"/>
        </source>
    </evidence>
    <sequence length="299" mass="31944" checksum="1AC06ABAEDA69D45" modified="2005-11-22" version="1">MDKTWAEVTCEIPAAMIDLLADFLVELSGNGVSIDNLELDTFSLDTMDEAPVKTVRAYFTPDDELEEKLAALNRFIQEHAPAYGDAAPAPPTVTTLREEDWATGWRQHFAPTRIGRKLVIKPTWEPFSPEPGDLVIELDPGMAFGTGTHPTTRLCLEALEKLGTAGDVLDVGTGSGILAMAAVKLGAQRVVGTDIDPDAVAVARENCAMNGVTAELVTTPLADIPGQFSVVLANILAEDLVRMAADLTAKVAPGGFLILSGILVERESYVIDGFVSTGLTLAETTREGEWSCLLYQAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QB2</accession>
    <name>Q39QB2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH dehydrogenase I, F subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nuoF-1</name>
        <name evidence="13" type="ordered locus">Gmet_3350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512576.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3350"/>
    <dbReference type="EnsemblBacteria" id="ABB33562">
        <property type="protein sequence ID" value="ABB33562"/>
        <property type="gene ID" value="Gmet_3350"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3350"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_7"/>
    <dbReference type="OMA" id="DKRCPSN"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="536"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB33562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="591" mass="64336" checksum="423C4F975541D9FD" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QE5</accession>
    <name>Q39QE5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bacterial SH3 domain lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3316</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366178.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3316"/>
    <dbReference type="EnsemblBacteria" id="ABB33529">
        <property type="protein sequence ID" value="ABB33529"/>
        <property type="gene ID" value="Gmet_3316"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3316"/>
    <dbReference type="HOGENOM" id="CLU_1756195_0_0_7"/>
    <dbReference type="OMA" id="HEGWVAG"/>
    <dbReference type="OrthoDB" id="2073997at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003646">
        <property type="entry name" value="SH3-like_bac-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08239">
        <property type="entry name" value="SH3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223261" evidence="2">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="SH3b" evidence="3">
        <location>
            <begin position="91"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="148" mass="15493" checksum="18915E8D4971013D" modified="2005-11-22" version="1">MNQHQTAMGIARMAFLLSLSLTAACATVNTAPVEEQAGPQAPETGLEAEPPAPVPAPAAPPAVAPVTPQASVTVTTIPLVPGKITPRQKYVNVRPEPSTGKKPVAVLSGGKYVEVLGREGTWVKIRWTRGKKAHEGWVAGKFVDTVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QI6</accession>
    <name>Q39QI6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366172.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3275"/>
    <dbReference type="EnsemblBacteria" id="ABB33488">
        <property type="protein sequence ID" value="ABB33488"/>
        <property type="gene ID" value="Gmet_3275"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3275"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_1_7"/>
    <dbReference type="OMA" id="LFGRHIG"/>
    <dbReference type="OrthoDB" id="1094814at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="188"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="448" mass="48709" checksum="E2E70B442D42BEB4" modified="2005-11-22" version="1">MTDLSLAQAQRVVLLLAGTVKGYSLYPEAHPAIAQPLRETCTILEQILRGRNDVRLGIHDGVLFLEQHLFFTPTASVDELAGILTAREIRAVTFLRGLVPDELAALVALLSRRELTGGGLAAELARRGGGHVALELEEHRQEEAEEFDPSATYRQAITAVSALFEDIENGRIPSTKMLHGVVDRVADLTIREPSTLLGLAMIKDYDNYTFFHSVNVGILAMALGAAFGMGKEELRELGMAGFLHDVGKTRVAKKILNKPGKLSPEEFEVMKRHAEDGARIIDEMEGISSGVARAVLGHHLGFDRTGYPGWAKELPFGRSCEIIAVADCYDAITTLRVYKPPLTPREAVEMIRGLAGTQLNPDLVETFTGMMGRYPVGTLVRLDTNEIAVVFRPPPPGGERPMVKVVKDGLGRVLPSPVVKDLAREEGVGIVAVVDPALAAVEVSRYLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QJ5</accession>
    <name>Q39QJ5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cheA64H</name>
        <name evidence="8" type="ordered locus">Gmet_3266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512703.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3266"/>
    <dbReference type="EnsemblBacteria" id="ABB33479">
        <property type="protein sequence ID" value="ABB33479"/>
        <property type="gene ID" value="Gmet_3266"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3266"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_6_7"/>
    <dbReference type="OMA" id="NELVECC"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="3"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="258"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="6">
        <location>
            <begin position="465"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="607" mass="66131" checksum="5BB27CF74555BC66" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QJ6</accession>
    <name>Q39QJ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Scaffold protein CheW associated with MCPs of classes 40H and 40+24H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheW64H</name>
        <name evidence="2" type="ordered locus">Gmet_3265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512702.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3265"/>
    <dbReference type="EnsemblBacteria" id="ABB33478">
        <property type="protein sequence ID" value="ABB33478"/>
        <property type="gene ID" value="Gmet_3265"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3265"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_1_7"/>
    <dbReference type="OMA" id="ANGPAYF"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="164" mass="18581" checksum="EFF9C63B71369901" modified="2005-11-22" version="1">METALQTKVEESRSELIQLVSFKLEQEEYGVNVLKVREIIRMPSITRVPNTPHYIEGVINLRGKVIPIISMRKRFSLPEGETSSQTRIMVIDMEGELMGFVVDAVSEVIRISESEIQPPPAVVNSAVEQECLAGVINQTDRLLFFLNLEKLISRDERSLFSGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QL3</accession>
    <name>Q39QL3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Biotin-dependent acyl-CoA carboxylase, carboxyltransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512686.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3248"/>
    <dbReference type="EnsemblBacteria" id="ABB33461">
        <property type="protein sequence ID" value="ABB33461"/>
        <property type="gene ID" value="Gmet_3248"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3248"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_6_2_7"/>
    <dbReference type="OMA" id="DFIEGYN"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="32"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="289"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="574" mass="62461" checksum="5868DE7766479FBB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QL6</accession>
    <name>Q39QL6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-lactate dehydrogenase, flavoprotein subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">larD</name>
        <name evidence="3" type="ordered locus">Gmet_3245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512683.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3245"/>
    <dbReference type="EnsemblBacteria" id="ABB33458">
        <property type="protein sequence ID" value="ABB33458"/>
        <property type="gene ID" value="Gmet_3245"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3245"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017779_9_2_7"/>
    <dbReference type="OMA" id="TPRTCGE"/>
    <dbReference type="OrthoDB" id="1188552at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="36"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="459" mass="49731" checksum="2A0575DDBDA49E9F" modified="2005-11-22" version="1">MLDNRIIDELKTIVGADNVATDRQDLICYGYDATQMEFLPDAVVHPGSPDEVSAVLKLANREQFPVYPRGAGSGFTGGALPKGGGIVLVVTRLNRILRIDTENLIAEVEPGVVTEQFQLEVEKLGLFYPPDPASLKFSTLGGNVAENAGGPRCVKYGVTRDFVMGLEVVLPSGEIIRTGGETYKGVVGYDLTRLLCGSEGTLGVITKIIFKLLPLPEAKKTMMTIFDSIDGAAKAVSTIIGNKIIPTTLEFMDHATLQCVEKRFNLGIPASGRAVLIIEVDGDRDLIEKQAARIQELIKPLGLVECKIAKDAAESEALWKVRRLVSPSLRDVNPDKFNEDIVVPRSKVPDVIRVIEKIQQKYAIPIVNFGHAGDGNIHVNIMIDKSVAGQEEKAHEAIAEVFQAALDLNGTMSGEHGVGLAKQPYIHLELKPAQVATMQAIKKALDPNNILNPGKMFPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QM9</accession>
    <name>Q39QM9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heme exporter protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_3232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CcmC/CycZ/HelC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512671.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3232"/>
    <dbReference type="EnsemblBacteria" id="ABB33445">
        <property type="protein sequence ID" value="ABB33445"/>
        <property type="gene ID" value="Gmet_3232"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3232"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049710_2_2_7"/>
    <dbReference type="OMA" id="MPGEFIT"/>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003557">
        <property type="entry name" value="Cyt_c_biogenesis_CcmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01386">
        <property type="entry name" value="CCMCBIOGNSIS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="10">
        <location>
            <begin position="63"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="271" mass="30437" checksum="74C23DE8E72F8673" modified="2005-11-22" version="1">MNALFFKLTLAIYFAATIAYLAYLVKPREVLGKVSCWILSAGFVAHCAYTVDRYLEAGHTPITNLHESLSFFSLAVVGIYILFERKYRIFILGSFVTPVAFLLMAASTGFPSAIMPLNPALKSKWLMVHTVMAFLSYAAFSVAFGAAIMYLIQQHFLKSKKLGPMYQKLPSLDILDEINYRCLTIGFPLLTFAIISGAIWAESAWGTYWSWDPKETWSLITWFVYAALLHGRLTTGWRGKKAAILAIVGFFVLLFTFLGVNLFLSGLHSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QX2</accession>
    <name>Q39QX2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3139"/>
    <dbReference type="EnsemblBacteria" id="ABB33352">
        <property type="protein sequence ID" value="ABB33352"/>
        <property type="gene ID" value="Gmet_3139"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3139"/>
    <dbReference type="eggNOG" id="ENOG5033GX9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833566_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="333" mass="38115" checksum="E78EFD9E09A86C6A" modified="2005-11-22" version="1">MRMISQSDFPQADRLEKVGEVAIAVSQGNFSDVSIEGVIGLDSGGRQGRYYRLAAEILGLIVTSNNHSELTALGKEFSSLNTSSARNEFLTRCVLDSIVFQRAIAYINSDHPTEAQLRLWFLKFYPGAESTAKRRFSTFINYLNYLVKNKTIVINKDNYILNKYIGAAVKTKTLLCDGISDKEFKSDPKVGKKIKFEVQSQKLDRANQIHWNLVTAKSLFLKNKNLPAFENEIIDLYSKNNKDIVLYEMKSITDTNFVSQIRKALSQLYEYRYVFSEPNACICIVTNAPISKKDKWVIDYLNNDRLIAYEWTEDFKTFECHDGSQKLLSYFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R28</accession>
    <name>Q39R28_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aspartate ammonia-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">aspA</name>
        <name evidence="4" type="ordered locus">Gmet_3082</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514536.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3082"/>
    <dbReference type="EnsemblBacteria" id="ABB33296">
        <property type="protein sequence ID" value="ABB33296"/>
        <property type="gene ID" value="Gmet_3082"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3082"/>
    <dbReference type="eggNOG" id="COG1027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021594_4_1_7"/>
    <dbReference type="OMA" id="HDSMGEV"/>
    <dbReference type="OrthoDB" id="734949at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lyase_1" evidence="2">
        <location>
            <begin position="11"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="FumaraseC_C" evidence="3">
        <location>
            <begin position="406"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="469" mass="49678" checksum="453C23E487F48AE0" modified="2005-11-22" version="1">MTFRIEKDTLGDVQVPAGAYYGAQTARAVANFPLSGLRPHPALVRATVVIKKSAARANMTTGRLDPRLGEAIVRAADEALAGDFDPHFVVDPFQAGAGTSHNMNVNEILANRANELLGGERGAYAPVHPNDHVNMAQSTNDVFPTAMRLASLSLVEKLRPGLEGLVAALRGKGREFDAVLKSGRTHLQDAVPIRLGQEFEAWAVAMEKNLAGIDAALPGLRELGIGGTAVGTGMNAEAAYIDLVVAELARETGFPLHRGTNLVERMQNMDPFVALSSALKGLAANLVRIANDLRLLSSGPRTGLAEIALPAIQPGSSIMPGKVNPSMAEATDMVAFQVMGADAVITLAAQAGQLELNVMMPVIAFNLLFSLEILKNTVPRLVQACIAGITADRERCRRYLDQSVGLATVLAPYVGYAAAAEVAKESTATGRSIREIVEERQLLTADKLAEILDPLPLTSPGVPGEKHND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R44</accession>
    <name>Q39R44_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3065</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3065"/>
    <dbReference type="EnsemblBacteria" id="ABB33280">
        <property type="protein sequence ID" value="ABB33280"/>
        <property type="gene ID" value="Gmet_3065"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3065"/>
    <dbReference type="HOGENOM" id="CLU_2246106_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="104" mass="11561" checksum="0C93C8AF3C1DE8AB" modified="2005-11-22" version="1">MNAKTSPVVATMLLLLAAGCSDNDSHKRGVGEFDVSTSSRNPAVKDMTLLHGDSRLQTDSLPGRIKRLKREIARGESIYTREELGILERKLADSEEQFRVIQHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R66</accession>
    <name>Q39R66_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-dependent RNA helicase RhlE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rhlE-1</name>
        <name evidence="11" type="ordered locus">Gmet_3043</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513603.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3043"/>
    <dbReference type="EnsemblBacteria" id="ABB33258">
        <property type="protein sequence ID" value="ABB33258"/>
        <property type="gene ID" value="Gmet_3043"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3043"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_28_3_7"/>
    <dbReference type="OMA" id="YDIELYQ"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="32"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="370"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="452" mass="49159" checksum="23790330CA43CF30" modified="2005-11-22" version="1">MTFAELNLLPPILKAVAACGYTDPTPIQAQAIPRALEGRDLLATAQTGTGKTAAFVLPALQRLARPAQKPGRGPRVLVLTPTRELAQQVTDAVRSYGKFLRIRSGAILGGMPYREQLRLLSAPVDLIVATPGRLVDLLDRRSLDLSRLELLILDEADRMLDMGFSDDVDRVAAASPSDRQTLLFTATMDATMARLAGRLLNEPERIEVAGTKTTHEHIEQRLHVADDLSHKNRLLQHLITDGDVRKAIIFSATKRDAENMAIELRSQGHSAAALHGDMPQSARNRTIAAMKQGRIRLLVATDVAARGLDVSGISHVINFDLPKFAEDYVHRIGRTGRAGASGIAISFASLNEVSYLARIERYIGQTLPEHQIPGLEPRRPLHRVSTGRGSRPGNSTGGPRKSYGNRDAAKTGGRPGNAKRSPWGKHTTSNGPVVEYRSSKGREGSGQPRRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R69</accession>
    <name>Q39R69_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DUF362 iron-sulfur cluster-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366136.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3040"/>
    <dbReference type="EnsemblBacteria" id="ABB33255">
        <property type="protein sequence ID" value="ABB33255"/>
        <property type="gene ID" value="Gmet_3040"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3040"/>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058393_1_0_7"/>
    <dbReference type="OMA" id="KAWWHME"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="376" mass="40902" checksum="C09D27ED6373E15C" modified="2005-11-22" version="1">MRHAVAIERAGDYQSDVVRPALDRLLEPFGGMASFVKPGERVLLKPNMLAAKEPERAVTTHPELLRQVIGLVREAGGIPLVGDSPGVGGIRRVAERSGILAVVEETGAEFIPFDETVTVRGKGLFREFQIARPYLEADRLINLPKLKTHEMMTMTCAVKNLFGAVVGAAKAGWHLKAGADRELFARMLLEIYLLRRPDLTIVDGILAMEGDGPGSGDPRLCGLLLAGTNPVAVDVIAAELAGIPKKLLWVERAAEKLGIEGWDRATIDTRGVPVDEAKVSPFRLPHISDVQFGLPRFLKNRLRHYLTSRPCGNPEACTLCGICRDACPPGAITIQDGKLAFDYHACIRCFCCRELCPEGALGVREGALLKMIKKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RD5</accession>
    <name>Q39RD5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease MutS2</fullName>
            <ecNumber evidence="7">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mutS2</name>
        <name evidence="10" type="synonym">mutS-2</name>
        <name evidence="10" type="ordered locus">Gmet_2974</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512907.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2974"/>
    <dbReference type="EnsemblBacteria" id="ABB33189">
        <property type="protein sequence ID" value="ABB33189"/>
        <property type="gene ID" value="Gmet_2974"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2974"/>
    <dbReference type="eggNOG" id="COG1193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011252_2_1_7"/>
    <dbReference type="OMA" id="IHAIIND"/>
    <dbReference type="OrthoDB" id="256392at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03280">
        <property type="entry name" value="ABC_MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00092">
        <property type="entry name" value="MutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005747">
        <property type="entry name" value="MutS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF14">
        <property type="entry name" value="PTHR11361:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005814">
        <property type="entry name" value="MutS_YshD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01069">
        <property type="entry name" value="mutS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="9">
        <location>
            <begin position="710"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="517"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="340"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="785" mass="86816" checksum="7659A478E818F0FE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RG3</accession>
    <name>RECO_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA repair protein RecO</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombination protein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recO</name>
        <name type="ordered locus">Gmet_2943</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in DNA repair and RecF pathway recombination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512879.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RG3"/>
    <dbReference type="SMR" id="Q39RG3"/>
    <dbReference type="STRING" id="269799.Gmet_2943"/>
    <dbReference type="EnsemblBacteria" id="ABB33161">
        <property type="protein sequence ID" value="ABB33161"/>
        <property type="gene ID" value="Gmet_2943"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2943"/>
    <dbReference type="eggNOG" id="COG1381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066632_2_0_7"/>
    <dbReference type="OMA" id="LCTQSET"/>
    <dbReference type="OrthoDB" id="1758685at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00201">
        <property type="entry name" value="RecO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022572">
        <property type="entry name" value="DNA_rep/recomb_RecO_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003717">
        <property type="entry name" value="RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042242">
        <property type="entry name" value="RecO_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33991">
        <property type="entry name" value="PTHR33991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02565">
        <property type="entry name" value="RecO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11967">
        <property type="entry name" value="RecO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="SSF57863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00613">
        <property type="entry name" value="reco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264818" description="DNA repair protein RecO">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00201"/>
        </source>
    </evidence>
    <sequence length="244" mass="26429" checksum="8A130297B98D860A" modified="2005-11-22" version="1">MESTRTEAIVLAAMDYRESDRIVTLFTLQYGKVRGVAKGAKRSARRFGPALEPFARIGVELVVREGLSSLRGADIVTLYPGIRRDLRAIGLAGYAVELVDRYLPDGAPSPRLFRLLSSYLERLDQGEPLPSDRRFFEANFLNILGYRISLDHCASCGVELPATAERRTGASGMILCANCGRYGASVGPEAAALLGRCIATGRFGAVLFSPQSLREAGTLLDGAIAAHLTRPLNSLAFLKQIEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RH9</accession>
    <name>Q39RH9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512863.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2927"/>
    <dbReference type="EnsemblBacteria" id="ABB33145">
        <property type="protein sequence ID" value="ABB33145"/>
        <property type="gene ID" value="Gmet_2927"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2927"/>
    <dbReference type="HOGENOM" id="CLU_189842_1_1_7"/>
    <dbReference type="OMA" id="AKESAHH"/>
    <dbReference type="OrthoDB" id="1988737at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223174" evidence="2">
        <location>
            <begin position="22"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="76" mass="8167" checksum="F7F2AC79C1A963E0" modified="2005-11-22" version="1">MKRSLAQTIAVWLGMAVPALAASGAREDNSGIFVWIFLGFCALIVVAQLLPALLMMLGFAKGLKKEQPMAKESAHH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RJ8</accession>
    <name>ALR_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alanine racemase</fullName>
            <ecNumber evidence="1">5.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="primary">alr</name>
        <name type="ordered locus">Gmet_2908</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-alanine = D-alanine</text>
            <dbReference type="Rhea" id="RHEA:20249"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="5.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alanine racemase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512844.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RJ8"/>
    <dbReference type="SMR" id="Q39RJ8"/>
    <dbReference type="STRING" id="269799.Gmet_2908"/>
    <dbReference type="PRIDE" id="Q39RJ8"/>
    <dbReference type="EnsemblBacteria" id="ABB33126">
        <property type="protein sequence ID" value="ABB33126"/>
        <property type="gene ID" value="Gmet_2908"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2908"/>
    <dbReference type="eggNOG" id="COG0787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028393_2_2_7"/>
    <dbReference type="OMA" id="HMTHFSD"/>
    <dbReference type="OrthoDB" id="859043at2"/>
    <dbReference type="UniPathway" id="UPA00042">
        <property type="reaction ID" value="UER00497"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008784">
        <property type="term" value="F:alanine racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030632">
        <property type="term" value="P:D-alanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01201">
        <property type="entry name" value="Ala_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000821">
        <property type="entry name" value="Ala_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011079">
        <property type="entry name" value="Ala_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020622">
        <property type="entry name" value="Ala_racemase_pyridoxalP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00842">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00992">
        <property type="entry name" value="ALARACEMASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01005">
        <property type="entry name" value="Ala_racemase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00492">
        <property type="entry name" value="alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00395">
        <property type="entry name" value="ALANINE_RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000164597" description="Alanine racemase">
        <location>
            <begin position="1"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for D-alanine" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; specific for L-alanine" evidence="1">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01201"/>
        </source>
    </evidence>
    <sequence length="379" mass="41179" checksum="01C43A0EEAC66C70" modified="2005-11-22" version="1">MDSRPTIAEIDLAALRHNFEQVQRAVPAGCGILAIVKADAYGHGFMDISRELESLGVTAFGVAFLAEGIQLRKSGIDRPVLILGGVYPGQERKCVGFNLSTAVFSLEQARVLNDTAARLYRKAKIHVKIDTGMGRLGVAAAEAPAFFRELREMKSLELEGIISHFASADELDDDGRRFSDRQAAVFAQSVAEARSLGLDPRYVHIANSAAAFGMDLPFCNLVRPGIVLYGALPSGDFEGKMALRPIMRLQSTVAMLKWVEPGTSISYARRYTAPDRRLIASVPVGYADGYSRALTNRGEVLIRGTRAPVVGTVCMDWIMIDVTSVPGVAVGDEVTLLGCDRQGHCVRAEELASWAGTIPYEIFCGISKRVPRVYLNATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RL0</accession>
    <name>Q39RL0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2896</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512832.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2896"/>
    <dbReference type="EnsemblBacteria" id="ABB33114">
        <property type="protein sequence ID" value="ABB33114"/>
        <property type="gene ID" value="Gmet_2896"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2896"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076833_0_0_7"/>
    <dbReference type="OMA" id="CHTPHNS"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010177">
        <property type="entry name" value="Paired_CXXCH_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09699">
        <property type="entry name" value="Paired_CXXCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223456" evidence="1">
        <location>
            <begin position="24"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="2">
        <location>
            <begin position="200"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="240" mass="24957" checksum="DE150F7355103770" modified="2005-11-22" version="1">MKRRILMTLAALALMGMASSSGAAPSGTVKGIKGSPHDLSFTTPGTNQTDQVCVFCHTPHNAVQAVPLWNRNASTNTASSFKLYTSSQTFDMKPNPSRNGFTADSISLFCMSCHDGSALGGSMIGAEPVGVSNNALIPNGGDTTTAASKIVGSANFGTDLTKSHPVNFVYDSTKDAGIVANATLLAGKKFPLFKADGVANNLECASCHAVHGQTNTTYNYPKFLRSTMAGSALCLGCHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RS5</accession>
    <name>Q39RS5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366110.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2831"/>
    <dbReference type="EnsemblBacteria" id="ABB33049">
        <property type="protein sequence ID" value="ABB33049"/>
        <property type="gene ID" value="Gmet_2831"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2831"/>
    <dbReference type="eggNOG" id="ENOG503001N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_600985_0_0_7"/>
    <dbReference type="OrthoDB" id="200714at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025388">
        <property type="entry name" value="Alginate_export_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13372">
        <property type="entry name" value="Alginate_exp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alginate_exp" evidence="1">
        <location>
            <begin position="67"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="455" mass="48818" checksum="9BBCB0AE6D6FC90A" modified="2005-11-22" version="1">MIEFHVKRIRMARNTTIGAALIVLATAGRGVAAAEGEAPVIPVIQQQYVQGGAREGEAKDPLQFGPLKAGLDAMIRGESVNNFNLNDVTHTPGHRDSRLLVRVRPSLTVTPTDYLTARVEGQWYASYNDVKFNTFRLYQGYLEGSLPGRKATLKAGRQELVYGSSFMLGADTFFDGLSYDAVKLMVKPMEPLAVDFFAGKYLKDNSGGITGELYGVYGTYTANDAFSVDIYGLLDTGGAGMTHDGKDERTWSVGARLAGKVGKLVAFEVEPVYQFGRHIEETAHRNISAFGGHADLSIDPALGRYPSKGFVSYAFGSGDGGGNGKFREFHNPNNDTPLIGDMSVVGDLSGVTAIGPGGNAVHASGLHVITVGGGVDVTEKLNVSLDGHYFWATKTAAGVSTDVGFESNLIFTYKLTDKISFLAGANRFFTGNFFKDATGSGKDINYGYLQVQVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RV8</accession>
    <name>Q39RV8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366102.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2798"/>
    <dbReference type="EnsemblBacteria" id="ABB33016">
        <property type="protein sequence ID" value="ABB33016"/>
        <property type="gene ID" value="Gmet_2798"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2798"/>
    <dbReference type="HOGENOM" id="CLU_2382022_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="94" mass="10570" checksum="517B9F10283E3EF4" modified="2005-11-22" version="1">MQRHRIAVASNLSGKIGEMGFFLDQIVGVSRIIERKHVAQNYPINIELDRLNYFFSAYLNSIQAIKDACQTSMGANVTWEQIVSGNVKMTHLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S04</accession>
    <name>Q39S04_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="6">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">aceF</name>
        <name evidence="10" type="ordered locus">Gmet_2752</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + acetyl-CoA = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:17017"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="2.3.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511707.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2752"/>
    <dbReference type="EnsemblBacteria" id="ABB32970">
        <property type="protein sequence ID" value="ABB32970"/>
        <property type="gene ID" value="Gmet_2752"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2752"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_2_7"/>
    <dbReference type="OMA" id="QVTVIKH"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="PTHR23151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="431" mass="45985" checksum="E8E8D6BB76573087" modified="2005-11-22" version="1">MPTDITMPKLSDTMTEGRLVSWKKSVGERVERGEIIAEVETDKATMELEAFASGTLAEQRVKPGELVAVGTVIGVIGAGGEIPPVAPEKPTPSPEEPKPSPEESKPSPQKAEPQPTPEATPAAPAGDVPERVMELPEEKASAPAPPEAERGEGERAAPVVRRMARERGIDLSLVTGSGPEGRILQEDLERYLTEKPAPESAVATGEGAEGEPLSRMRGAIARVTSQAWQTIPHFYETVEIAMEEGVEIVRELKGSGNEVTFNDLVVKAAAMALAKYPRLNASFAGDRIVTHCEVNIGIAVAVDDGLLVPVVKGCQGLALKEIALETVRLADRARSGRISQEEISGGTFSISNLGMFGIDEFAAVIFPPQAAILAVGNVADRPVVRDGRVVAAKTMRVTLSCDHRIVDGAYAARFLGEFRRIVEKPVLMLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S40</accession>
    <name>Q39S40_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypoxanthine/guanine phosphoribosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511744.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2716"/>
    <dbReference type="EnsemblBacteria" id="ABB32934">
        <property type="protein sequence ID" value="ABB32934"/>
        <property type="gene ID" value="Gmet_2716"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2716"/>
    <dbReference type="eggNOG" id="COG0634">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073615_2_0_7"/>
    <dbReference type="OMA" id="TMDWMAV"/>
    <dbReference type="OrthoDB" id="1819460at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="185" mass="20985" checksum="45D3B0F126686EAC" modified="2005-11-22" version="1">MSVTLDEVKQVYAEADCLYTAPQVEETIDRMAREITARLADANPVVFCVMKGGIIVTGKLLPKLEFPLEAEYLHATRYGHKLYGTVLDWKVRPTKELKDRTVLIIDDILDEGETLGAIADWCRGMEAKEVLTAVLIDKEHDRKARPDLVPEFVGLRTPDRYLFGFGMDYKGYWRNAPGIFALKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S41</accession>
    <name>Q39S41_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hypoxanthine/guanine transport membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pbuG</name>
        <name evidence="8" type="ordered locus">Gmet_2715</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511745.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2715"/>
    <dbReference type="EnsemblBacteria" id="ABB32933">
        <property type="protein sequence ID" value="ABB32933"/>
        <property type="gene ID" value="Gmet_2715"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2715"/>
    <dbReference type="eggNOG" id="COG2252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024508_0_1_7"/>
    <dbReference type="OMA" id="RKGSYFF"/>
    <dbReference type="OrthoDB" id="558559at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904823">
        <property type="term" value="P:purine nucleobase transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026033">
        <property type="entry name" value="Azg-like_bact_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="PTHR43337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005353">
        <property type="entry name" value="PbuG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="436" mass="46660" checksum="B1D39C64DF6F6ABA" modified="2005-11-22" version="1">MKTIASFFRFDHYRTSFRKETVAGITTFLTMAYIIIVNPAILEAGGIPRGPQTTATILAAVFGCVVMALWANRPFAIAPYMSENAFVAFTVVKTLGYTWQTAMGAVFVAGIVFSILTVFRVRSWLAEAIPLSLKCAFAVGIGLFLTFIGLNETGLVTLGVAGAPVKMGNIAAPSVLLAVFGYLLTVFLMTRQVRGAIVIGIVATTTLSIAFGVTPMPKEFVSLPPDISPILFQLDIGSVFEIRFFPVVLTIFIMAFLDTVGTLIGLSMRADLLDEHGNLPEIEKPMLADALATTVAPLLGTTTTGAYIESAAGIEEGGRTGFTALVVAGLFLLALFFAPLFTIVPSHAYGIALIVIGSFMIEPIKRIAFDDFTELVPAFLTIVLMIFTYNIGVGMSTGLLTYPLLKAAAGRGREVPAGMWVLALLAVSLFVFFPKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S44</accession>
    <name>Q39S44_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511748.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2712"/>
    <dbReference type="EnsemblBacteria" id="ABB32930">
        <property type="protein sequence ID" value="ABB32930"/>
        <property type="gene ID" value="Gmet_2712"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2712"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="TQKVRSV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="204"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="170"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="414" mass="46601" checksum="AAF11AD257C42774" modified="2005-11-22" version="1">MGATTEQSNGNILIIEDSPTQSAQLRHIMETNGYHVISACNGREALALLSGQTPSLIISDVIMPGIDGYELCRRIKEREDSRNIPVILLTSLSDPHDVIRGLECGADNFITKPCNEKHLLSRVSYLLESRNPCQIEARSGLEILFGGERYCITADRRQILDLLLCTYETAIQKNDALIRAQDELSRLNQQLETTNRELEAFNYTVSHDLRSPLTNISGYCQVLQELHGDTLDPTCQDYIQEIYRATMRMNDLIGDLMEFSRLNHQELQRQEVNLSTMARIIAVELKSKDRERRVEFRIADGIVGNGDSRLLQLVLVNLLGNAWKYTGKKENAVIEFGVTNTEGKEVYFVRDNGAGFDMAEAHRLFGTFQRLHSKQEFEGTGIGLATVQRIIQRHGGSIRGEGEVGKGATFYFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S72</accession>
    <name>Q39S72_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-methyl-5'-thioadenosine phosphorylase</fullName>
            <ecNumber evidence="1">2.4.2.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5'-methylthioadenosine phosphorylase</fullName>
            <shortName evidence="1">MTA phosphorylase</shortName>
            <shortName evidence="1">MTAP</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mtaP</name>
        <name evidence="1" type="synonym">mtnP</name>
        <name evidence="3" type="ordered locus">Gmet_2684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (phosphorylase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer. Dimer of a homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.28" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511776.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2684"/>
    <dbReference type="EnsemblBacteria" id="ABB32902">
        <property type="protein sequence ID" value="ABB32902"/>
        <property type="gene ID" value="Gmet_2684"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2684"/>
    <dbReference type="eggNOG" id="COG0005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054456_0_1_7"/>
    <dbReference type="OMA" id="MTQCPEA"/>
    <dbReference type="OrthoDB" id="1364220at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00873"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09010">
        <property type="entry name" value="MTAP_SsMTAPII_like_MTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01963">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010044">
        <property type="entry name" value="MTAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42679">
        <property type="entry name" value="PTHR42679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01694">
        <property type="entry name" value="MTAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="1" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="6"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="54"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphate binding" evidence="1">
        <location>
            <begin position="87"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="1">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="287" mass="30912" checksum="7EF11128377C62DB" modified="2005-11-22" version="1">MSEQVIGVIGGSGLYEMEGLSDVRSVVVETPFGAPSDEFMTGVLDGVQMVFLPRHGKGHRLLPSEVNYRANIYGMKKLGVTRIISVSAVGSMKEEIAPGHIVIPDQFIDRTNATRANTFFGNGVVAHVQFADPVCADLSGWLYEAALAAGATVHRGGTYICMEGPAFSTRAESNLYRSFGVSVIGMTNIPEAKLAREAEICYGVIALSTDYDCWHESHDDVSVDAILAIIRQNVAMSKSIIGHAVKRISAERACPCASALTYAIITDRSAIPAEARERLDLIIGKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SH7</accession>
    <name>Q39SH7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513456.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2578"/>
    <dbReference type="EnsemblBacteria" id="ABB32797">
        <property type="protein sequence ID" value="ABB32797"/>
        <property type="gene ID" value="Gmet_2578"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2578"/>
    <dbReference type="eggNOG" id="ENOG5032SH9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124431_0_0_7"/>
    <dbReference type="OMA" id="GGFVEHY"/>
    <dbReference type="OrthoDB" id="2010326at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021218">
        <property type="entry name" value="DUF2784"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10861">
        <property type="entry name" value="DUF2784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="119" mass="13294" checksum="7D5D742EA1C38F80" modified="2005-11-22" version="1">MGYSLLADAVVLVHGLFVLFVVLGGLVVLRWPRLAWLHVPAAIWGAMIELSGKVCPLTYLEVRFRRLAGETGYTESFIEHYIVPLIYPPGLTRGWQIAVGLLVAALNLAVYGVLHRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SH8</accession>
    <name>Q39SH8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent enal/enone/nitroreductase, Oye family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">namA</name>
        <name evidence="2" type="ordered locus">Gmet_2577</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513457.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2577"/>
    <dbReference type="EnsemblBacteria" id="ABB32796">
        <property type="protein sequence ID" value="ABB32796"/>
        <property type="gene ID" value="Gmet_2577"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2577"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_0_7"/>
    <dbReference type="OMA" id="ASMQRPW"/>
    <dbReference type="OrthoDB" id="1033671at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="PTHR43303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="355" mass="38747" checksum="1F690BA54E927F36" modified="2005-11-22" version="1">MSALFTPFTLRSVTFRNRIFVSPMCQYSSLDGMPTDWHLVHLGSRAVGGAGLVMVEATAVSPEGRISPDDSGIWDDRHGEGFAPITRFIAEQGAVPGIQLAHAGRKASTDLPWRGGLPLGPEARGWQPVAPSPRPFAADYPVPRELTVEEMDDVVSQFRDGAQRALAAGFQVVEIHMAHGYLLHEFLSPLSNRRTDDFGGSLENRIRLPLRVTRAVREVWPADLPLFVRISATDWVEGGWDLDQSVVLARKLREAGVDLVDCSAGFLTPDAVIPFGSGYQTPFATAIRREAGIPTGTVGFITDPAQAEQIVATGLADAVLLAREMLRDPYWPLHAARSLGVNVPWPPQYERAKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SJ6</accession>
    <name>Q39SJ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor cyclic diguanylate phosphodiesterase, GAF and GAF domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513475.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2559"/>
    <dbReference type="EnsemblBacteria" id="ABB32778">
        <property type="protein sequence ID" value="ABB32778"/>
        <property type="gene ID" value="Gmet_2559"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2559"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_13_7"/>
    <dbReference type="OMA" id="RPYKKGY"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="348"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="370"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="553" mass="61079" checksum="F5ED311A21703F6D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SK2</accession>
    <name>Q39SK2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan-binding lipoprotein, OmpA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2553</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513481.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2553"/>
    <dbReference type="EnsemblBacteria" id="ABB32772">
        <property type="protein sequence ID" value="ABB32772"/>
        <property type="gene ID" value="Gmet_2553"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2553"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_14_0_7"/>
    <dbReference type="OMA" id="YVSMENK"/>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223233" evidence="3">
        <location>
            <begin position="25"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="163"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="35"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="292" mass="32190" checksum="A83BC73DE1A9EC8E" modified="2005-11-22" version="1">MAKRIVILMLLAFTSLSLSGCLVAESTYLKKAEEADTLGREAATLQEMHQKLSAENGALKAQLAKVREEAAGLAKEKEKLGADNKELEQVLRAKTDTLSQSVADLRQKVTDLETENTRLKAEIAETRKAREEKVREVSKTYEDLLDRMKGEIAQGQVTISELKGKLTVNMVDAILFDSGKAEVKQGGMEVLAKVVDILKGVQDKMIRIEGHTDNVQIVGNLTKRFPTNWELSAARAINVARYLQGQGIDPTVLVAVANGEYRPVASNDTEEGRAKNRRIEIVLVPRDAPDRP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SS2</accession>
    <name>TRPA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tryptophan synthase alpha chain</fullName>
            <ecNumber evidence="1">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpA</name>
        <name type="ordered locus">Gmet_2477</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpA family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512422.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SS2"/>
    <dbReference type="SMR" id="Q39SS2"/>
    <dbReference type="STRING" id="269799.Gmet_2477"/>
    <dbReference type="EnsemblBacteria" id="ABB32702">
        <property type="protein sequence ID" value="ABB32702"/>
        <property type="gene ID" value="Gmet_2477"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2477"/>
    <dbReference type="eggNOG" id="COG0159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_0_2_7"/>
    <dbReference type="OMA" id="LVMTYWN"/>
    <dbReference type="OrthoDB" id="912786at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43406">
        <property type="entry name" value="PTHR43406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_1000018207" description="Tryptophan synthase alpha chain">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00131"/>
        </source>
    </evidence>
    <sequence length="269" mass="28300" checksum="C6C0CD2FFB7CFA94" modified="2005-11-22" version="1">MSRITGTFAELKRTGKKALVTFITAGDPDLATTEELIPLLAENGADIIELGVPFSDPMADGPTIQLSSERALAAGTTLSRILATVKSVRGRTQVPIVLMGYFNPIFSYGLERFAADAAAAGVDGVLLVDLPPEEAGEFKACADRHGIDVIFLLTPTSDETRIRTVTNRARGFIYYVSVTGVTGVRSGIEASVAGNVNIIKECSKVPVAVGFGIATPEQAGEVAATADGVVVGSAIVKLFEKHRGEELKGALATFVSSLKQAVDRGRYDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T72</accession>
    <name>KGUA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanylate kinase</fullName>
            <ecNumber evidence="1">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gmk</name>
        <name type="ordered locus">Gmet_2327</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential for recycling GMP and indirectly, cGMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + GMP = ADP + GDP</text>
            <dbReference type="Rhea" id="RHEA:20780"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513293.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T72"/>
    <dbReference type="SMR" id="Q39T72"/>
    <dbReference type="STRING" id="269799.Gmet_2327"/>
    <dbReference type="EnsemblBacteria" id="ABB32552">
        <property type="protein sequence ID" value="ABB32552"/>
        <property type="gene ID" value="Gmet_2327"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2327"/>
    <dbReference type="eggNOG" id="COG0194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001715_1_2_7"/>
    <dbReference type="OMA" id="EWAVVHG"/>
    <dbReference type="OrthoDB" id="1502854at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:guanylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00328">
        <property type="entry name" value="Guanylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000266329" description="Guanylate kinase">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00328"/>
        </source>
    </evidence>
    <sequence length="203" mass="23403" checksum="49821F1711740F98" modified="2005-11-22" version="1">MKREGVLYIISAPSGAGKTTLCKEIIDIFPHLRHSVSYTTRQPRAGEVHGKDYYFISMDEFRSMVDKGEFAEWAEVHGNCYGTSIRTLEECRITGIDLILDIDIQGARQLKERYEGGVYIFILPPSYEELRRRLNGRSSDSDDVISRRIDAAAGEIRESRWYDYIIVNDQFSRAVEELKSVVVAERCRTFRVLETVTERFDMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T86</accession>
    <name>Q39T86_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulator, PATAN and FRGAF domain-containing, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513307.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2313"/>
    <dbReference type="EnsemblBacteria" id="ABB32538">
        <property type="protein sequence ID" value="ABB32538"/>
        <property type="gene ID" value="Gmet_2313"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2313"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_699722_0_0_7"/>
    <dbReference type="OMA" id="QYLAMEG"/>
    <dbReference type="OrthoDB" id="545478at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="2">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="394" mass="43537" checksum="E076CDD0CAC6CB28" modified="2005-11-22" version="1">MSLVGSLEDLGLGEILQIISLSSKSGILRIKSRGREGTIVFRLGQVIQATSSTLLENIGEVLIRKGKLDLATLRSALACQESEGFQERLGSILVRRFGVPATVVEDVAREQVERVVYTLFAWVEGTFEFILQDNVATAGTIRMDPLQFMLEQGLNPRLLMAEANQDRRRRDIPRDEEPLRVPQPPEGRTVVPAPPPGHINIGEELRLEMGEELAKTGEEGYSHADRMTLLRGMLEELHNPELGCGITLLVLRLAAEFMDRAVIFRVLKEEVVGLGQFGLDDRGGGADERIRSLRIPRGEPSLFSGVIEAKHPAVVRPEANEWNRYLFGRIGVEIPHEVFLGPIVSGGEVIAVLYGDNQAERRPIVGTEALEIFLSQAGLVMEKALLESKLRSVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TH3</accession>
    <name>Q39TH3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2224"/>
    <dbReference type="EnsemblBacteria" id="ABB32451">
        <property type="protein sequence ID" value="ABB32451"/>
        <property type="gene ID" value="Gmet_2224"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2224"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_7"/>
    <dbReference type="OMA" id="ERYHPII"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="28147" checksum="8F1EE080D0C482D6" modified="2005-11-22" version="1">MGFQELLYEKTEGVGVITLNRPDRLNALNRTILLELIQVLQEATTDNEVRVVLITGAGKGFCAGGDLKGHPSFETSDPLVREGYVKESHQAILLLHHMPKPVVAAVNGVAAGAGMNIALSCDIRLASDTAVFTESFIKAGIMTDMGGSYFLPRIVGVGRAIEMILTAEKIDAAEACRIGLVNKVFPDAEFRTAALSYAKELAKGPRQAYKMAKWAIYTGLQLDLEDALKHEELGQALLIGTEDSSNAIKAFIEKRTPVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TK5</accession>
    <name>Q39TK5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2192</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365948.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32419">
        <property type="protein sequence ID" value="ABB32419"/>
        <property type="gene ID" value="Gmet_2192"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2192"/>
    <dbReference type="eggNOG" id="ENOG503001N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507859_0_0_7"/>
    <dbReference type="OrthoDB" id="200714at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025388">
        <property type="entry name" value="Alginate_export_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13372">
        <property type="entry name" value="Alginate_exp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223110" evidence="2">
        <location>
            <begin position="24"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_exp" evidence="3">
        <location>
            <begin position="186"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="568" mass="62369" checksum="9B8714BC5D429BD4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TM3</accession>
    <name>Q39TM3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Asparagine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">asnB-1</name>
        <name evidence="9" type="ordered locus">Gmet_2172</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365930.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2172"/>
    <dbReference type="EnsemblBacteria" id="ABB32401">
        <property type="protein sequence ID" value="ABB32401"/>
        <property type="gene ID" value="Gmet_2172"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2172"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014658_3_1_7"/>
    <dbReference type="OMA" id="IEHSHQP"/>
    <dbReference type="OrthoDB" id="610569at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01536">
        <property type="entry name" value="asn_synth_AEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="5">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="392"/>
            <end position="393"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="7">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="665" mass="74956" checksum="27AF405683B401FE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TS1</accession>
    <name>Q39TS1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513081.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2124"/>
    <dbReference type="EnsemblBacteria" id="ABB32353">
        <property type="protein sequence ID" value="ABB32353"/>
        <property type="gene ID" value="Gmet_2124"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2124"/>
    <dbReference type="eggNOG" id="ENOG5033VZ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1852311_0_0_7"/>
    <dbReference type="OMA" id="MINQSRR"/>
    <dbReference type="OrthoDB" id="2134974at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223508" evidence="1">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="139" mass="14959" checksum="AC0F1E1A8E80F628" modified="2005-11-22" version="1">MMETGRRGFFKQIFTAVAAVAATGATAAAPRRAEASVAGQIKGVCLYVPSLGKATDFVEMMNKNAPGSWTVHPLTGSLSEHYFTTRNLYEEARGSANTFVGVVDPATFAIVHEAIVDCGGSFHYTTYEDRNRVTFSAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TZ6</accession>
    <name>Q39TZ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster-binding oxidoreductase, cyano_FeS_chp family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514055.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2049"/>
    <dbReference type="DNASU" id="3739829"/>
    <dbReference type="EnsemblBacteria" id="ABB32278">
        <property type="protein sequence ID" value="ABB32278"/>
        <property type="gene ID" value="Gmet_2049"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2049"/>
    <dbReference type="eggNOG" id="COG1625">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037396_0_0_7"/>
    <dbReference type="OMA" id="CFIDQQP"/>
    <dbReference type="OrthoDB" id="504159at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007549">
        <property type="entry name" value="DUF512"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045375">
        <property type="entry name" value="Put_radical_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04459">
        <property type="entry name" value="DUF512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19238">
        <property type="entry name" value="Radical_SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDZ" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="433" mass="47823" checksum="4385E4F61030A514" modified="2005-11-22" version="1">MEGLLIDYVQPGSIAEELEIEAGDRLVAINGQDLRDIIDFSFYAHDEELALEIVKPSGDHWEAEIERDGDEPLGLVFAPPVPAQCGNKCVFCFVHQLPKGLRRPLYVKDEDYRLSFLYGNYVTLSNIRRGDLDRIVAQRLSPLYISVHATNPALRERLLGRSEILPILDLMRELAAARIVMHSQIVLCPGLNDGVELEKTVRDLAGLHPWVESLAIVPIGLTKHRRGLPALEPVTASYAETFVQNWQPAAERLERELGAPFLFIADEFYIKAGLPFPPLETYGDLPQIENGVGMIPLFLDESERVLKKARKGKPVTVTVVTGESPYRYLAAFLERLSVRTGATFKPVAVHNRLFGESVTVTGLVAGSDIVEELSGRDLGDAVLVPDVMLKEGEGIFLDDLSVDGLGKSLGTRVLVVEATPQGVVDALRRVRSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UB3</accession>
    <name>Q39UB3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1932</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511911.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1932"/>
    <dbReference type="EnsemblBacteria" id="ABB32161">
        <property type="protein sequence ID" value="ABB32161"/>
        <property type="gene ID" value="Gmet_1932"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1932"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_643658_0_0_7"/>
    <dbReference type="OMA" id="YQQSYSM"/>
    <dbReference type="OrthoDB" id="1514411at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039568">
        <property type="entry name" value="Peptidase_MA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13485">
        <property type="entry name" value="Peptidase_MA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223300" evidence="2">
        <location>
            <begin position="29"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="139"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_MA_2" evidence="3">
        <location>
            <begin position="283"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="426" mass="47540" checksum="F8D7467D6F6258F8" modified="2005-11-22" version="1">MRNLPACILVILCLLCAGEPLLSPVAAADPFLHNKYGVDLIERGEIEKAIEQLEKAYSLYSSDPILKGNLATAYALQGQRLLDRKSYADAAGQFEKALVLFPDEPRYHLLRGIAFTLAKNFPLARHELQQARNLGGETAEGLYFLGRIHYEEGETDEALQNWEKAAALAPSDPSLAKLLERMRREQAVETRMERGHSSRFIVSYDAGEVKTGIALDVLDVLETAYNSVGTDLGYFPEARVPVILYTKRDYREVTRSPNWSGGLYDGKIRIPIGGLVEITPDLRATLRHEYTHAVVRDLSRGNCPVWLNEGLAELQGRQELNPPLTELGRAIRTGGYLPLRKLENGFTSLGSSEVRLAYEESYAVVNFMVSSYGWYRVRGILTYIGEGLPVGEAINRGLADLGLDYDGVFGEWLEYMKREYGGEKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UD0</accession>
    <name>Q39UD0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Competence protein, ComEC-related, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1915"/>
    <dbReference type="EnsemblBacteria" id="ABB32144">
        <property type="protein sequence ID" value="ABB32144"/>
        <property type="gene ID" value="Gmet_1915"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1915"/>
    <dbReference type="eggNOG" id="COG0658">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010363_2_1_7"/>
    <dbReference type="OMA" id="RTDKQGA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030420">
        <property type="term" value="P:establishment of competence for transformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07731">
        <property type="entry name" value="ComA-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035681">
        <property type="entry name" value="ComA-like_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004477">
        <property type="entry name" value="ComEC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004797">
        <property type="entry name" value="Competence_ComEC/Rec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025405">
        <property type="entry name" value="DUF4131"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03772">
        <property type="entry name" value="Competence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13567">
        <property type="entry name" value="DUF4131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00360">
        <property type="entry name" value="ComEC_N-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00361">
        <property type="entry name" value="ComEC_Rec2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="7">
        <location>
            <begin position="541"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="798" mass="86114" checksum="514D3D5C4FCDF29C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UH8</accession>
    <name>Q39UH8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1867"/>
    <dbReference type="EnsemblBacteria" id="ABB32096">
        <property type="protein sequence ID" value="ABB32096"/>
        <property type="gene ID" value="Gmet_1867"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1867"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_764522_0_0_7"/>
    <dbReference type="OMA" id="CHGDSAN"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010177">
        <property type="entry name" value="Paired_CXXCH_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09699">
        <property type="entry name" value="Paired_CXXCH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223520" evidence="1">
        <location>
            <begin position="23"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="2">
        <location>
            <begin position="126"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="2">
        <location>
            <begin position="222"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="367" mass="40504" checksum="8C183B01EF30CFB9" modified="2005-11-22" version="1">MAIKNLILTLAFLLFMSPAPFAASYPKDAVHLDTNKVSTGCSTCHLSFNFKSGGGPETCIICHGDPSRLKQSYKNMPKNFAPAGSNRKNIEAEFLKTYHHPAFDARGIHQSNEILPETDSRIPRHAECVDCHNPHYVTSENKFAGIRGKRVGNVISSVNKEYELCYKCHGESANLPGRQVNKRMEFALTNPSFHPVEGEGKNTAVISLLKPYKEKKINAGEVATISCGDCHGSENPESPRGPHGSQYEHILVDHYSTSDKQSETPYTYALCYRCHDRTSILGNESFRYHALHIQGRGGGNGADSGTSCYTCHSSHGSPDNKYLITFNKSVVSPNSQGQLKFVEKGISTFRGECYLSCHGVDHNPKVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UI2</accession>
    <name>Q39UI2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II secretion system ATPase PulM, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pulM</name>
        <name evidence="1" type="ordered locus">Gmet_1863</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511983.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1863"/>
    <dbReference type="EnsemblBacteria" id="ABB32092">
        <property type="protein sequence ID" value="ABB32092"/>
        <property type="gene ID" value="Gmet_1863"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1863"/>
    <dbReference type="eggNOG" id="COG4972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905400_0_0_7"/>
    <dbReference type="OMA" id="TFYQGAM"/>
    <dbReference type="OrthoDB" id="1247869at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="309" mass="34364" checksum="2AB416FEC8AD007F" modified="2005-11-22" version="1">MFFSRNAVGMEITQHGVRMAAVGGSKNRPKLLACETAQFPAGTVRLVHREPNVVEPALFVKEVKEAYLKLLHRTGLVSVSLPDACGRVVILDLETRFKNRDEGYDIIRWKLKKSLPFDVNEMHLDYQLLREKENGEISVLVAIIARQVVSQYEELLAEAGIQPAHIDFTSFNLYRLFSPRIAMSESSLFVACHDNVLSILIFHQDVLEFYRAKELPGSDLDMNRVFMETNNSLLFYRDKNPGREFREAFCLAPAGDGELFRTVITEACGLEPFMLLPDTFVGNPASSVGGGGVPLASLAAALGAATRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UP0</accession>
    <name>Q39UP0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512041.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1805"/>
    <dbReference type="EnsemblBacteria" id="ABB32034">
        <property type="protein sequence ID" value="ABB32034"/>
        <property type="gene ID" value="Gmet_1805"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1805"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1649702_0_0_7"/>
    <dbReference type="OMA" id="AYSHRMV"/>
    <dbReference type="OrthoDB" id="1701211at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="17946" checksum="4808AD235C9974E5" modified="2005-11-22" version="1">MNAYEQISLQIPGEVERLMEDRSILREDAQKVILHAETTGRKLLNSATGHFLAFHRPKAVTYWAEYVRTGDDYRLVTAYSHRMAMKSSGSTQEWVKSGSGSEWLCNQCQAPLEEQTVRLQYMQSIFPITLPACSGCGFILVTEELATGKLAAAEQALEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UT7</accession>
    <name>Q39UT7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate synthase (NADPH)</fullName>
            <ecNumber evidence="3">1.4.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_1756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + L-glutamine + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="1.4.1.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.13" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365867.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1756"/>
    <dbReference type="EnsemblBacteria" id="ABB31987">
        <property type="protein sequence ID" value="ABB31987"/>
        <property type="gene ID" value="Gmet_1756"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1756"/>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023342_1_1_7"/>
    <dbReference type="OMA" id="FVSDMSF"/>
    <dbReference type="OrthoDB" id="151647at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004355">
        <property type="term" value="F:glutamate synthase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024188">
        <property type="entry name" value="GltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043578">
        <property type="entry name" value="GltB_archl_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500061">
        <property type="entry name" value="GOGAT_lg2_archl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006429">
        <property type="entry name" value="GOGAT_lg_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="509" mass="54867" checksum="276AF199FDF73970" modified="2005-11-22" version="1">MLYKSVTESFNEFIIDRSDATCIRCKVCVRQCAYEVHAYEAKADALTEDNTLCIGCRRCSALCPTGAITIRSNEEVFKRNESWSNAHIRNLYAQADTGGILLAAMGNPAKYPIYWDHMLLDASQVTNPSIDPLREPMELRTYLGKKPHSIEVVRDEQTGKPKLATKLTPQIKMEYPFIFSAMSYGALNLNAHKAMAMAAKELGTLYNTGEGGLHRDLYQYGSNVMVQVASGRFGVSEAYLNAGVAIEIKVGQGAKPGIGGHLPGEKVNDQISETRMIPAGADAISPAPHHDIYSIEDLRQLIFALKEATNYTKPVSVKIAAVHHVAAIASGVARAGADIITIDGFRGGTGAAPQVIRDNVGIPMELALAAVDARLRDEGIRNQVSIVVGGGVRSSGDAIKAIALGADAINMGTSTLLALGCTLCQRCYTGKCPWGITTNNPYLAKRLNPELGAERLVNLVHAWGHEMKEILGGMGLNALESLRGNRYKLRALGLTEKDMNILGVMPAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UW9</accession>
    <name>Q39UW9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513379.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1724"/>
    <dbReference type="EnsemblBacteria" id="ABB31955">
        <property type="protein sequence ID" value="ABB31955"/>
        <property type="gene ID" value="Gmet_1724"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1724"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060077_3_2_7"/>
    <dbReference type="OMA" id="AERCCGD"/>
    <dbReference type="OrthoDB" id="1748559at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00040">
        <property type="entry name" value="HTHMERR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00552">
        <property type="entry name" value="HTH_MERR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="97"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="134" mass="15704" checksum="A2F6F5E632D5E92F" modified="2005-11-22" version="1">MAPEQEAEQLITIGEVARMLDLTTRTLRYWEEMGVVEASHRSEGGNRLYTPYMVRRMKFIIKLKELGLTIKEMQELGAAYGEARKTENMIPRLVEILDSHINKVDEKMANLASLRKDIVDYRHRMIEKFNFSKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V70</accession>
    <name>NRDR_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcriptional repressor NrdR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nrdR</name>
        <name type="ordered locus">Gmet_1623</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NrdR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511441.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V70"/>
    <dbReference type="SMR" id="Q39V70"/>
    <dbReference type="STRING" id="269799.Gmet_1623"/>
    <dbReference type="EnsemblBacteria" id="ABB31854">
        <property type="protein sequence ID" value="ABB31854"/>
        <property type="gene ID" value="Gmet_1623"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1623"/>
    <dbReference type="eggNOG" id="COG1327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108412_0_0_7"/>
    <dbReference type="OMA" id="YRFTTYE"/>
    <dbReference type="OrthoDB" id="1551627at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00440">
        <property type="entry name" value="NrdR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003796">
        <property type="entry name" value="RNR_NrdR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30455">
        <property type="entry name" value="PTHR30455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00244">
        <property type="entry name" value="TIGR00244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_0000230870" description="Transcriptional repressor NrdR">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-cone" evidence="1">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="zinc finger region" evidence="1">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00440"/>
        </source>
    </evidence>
    <sequence length="150" mass="17500" checksum="5BDE69F13D3D5AD0" modified="2005-11-22" version="1">MKCPFCAHPDSKVVDSRPDKGGAAIRRRRECESCAKRFTTHERIEETLPLVLKKDGRREPFDRMKIVGGILKACEKRQVSRETVDRLVDRLEGRLQEWSEKEVPSTTIGEWVMTELHDIDEVAYVRFASVYRSFKDVNEFMAELQDLLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VA8</accession>
    <name>Q39VA8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription termination/antitermination protein NusA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">nusA</name>
        <name evidence="10" type="ordered locus">Gmet_1584</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Participates in both transcription termination and antitermination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511481.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1584"/>
    <dbReference type="EnsemblBacteria" id="ABB31816">
        <property type="protein sequence ID" value="ABB31816"/>
        <property type="gene ID" value="Gmet_1584"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1584"/>
    <dbReference type="eggNOG" id="COG0195">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029242_2_2_7"/>
    <dbReference type="OMA" id="MDIDMSA"/>
    <dbReference type="OrthoDB" id="384865at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00945_B">
        <property type="entry name" value="NusA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025249">
        <property type="entry name" value="KH_dom_NusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030842">
        <property type="entry name" value="NusA_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036555">
        <property type="entry name" value="NusA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013735">
        <property type="entry name" value="TF_NusA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010213">
        <property type="entry name" value="Tscrpt_termination_fac_NusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22648">
        <property type="entry name" value="PTHR22648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13184">
        <property type="entry name" value="KH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08529">
        <property type="entry name" value="NusA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69705">
        <property type="entry name" value="SSF69705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01953">
        <property type="entry name" value="NusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="5 7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 7" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="S1 motif" evidence="9">
        <location>
            <begin position="137"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="381" mass="42456" checksum="652031635F1EFF32" modified="2005-11-22" version="1">METTFNLKHIIDQIVKEKGIDRDIVVEALEQAVLSAANKKYRNTRDLEAHYNPEVGEVELFEFVTVVDEVMDSYKEIDLEEAREIDPDVEVGDSLGMKMDASGFTRIAAQTAKQVIIQKVREAERETIFNEFKDRIGELINGVVRRFEKGDLVVDLGRAEALLSNKEQAPREVYRQGDRIKALIMDIRMTPKGPQIILSRTHPGVLAKLFEAEVPEIAEGIVEIKSVVREPGSRSKIAVYSHDSDVDPVGACVGMRGSRVQNVVSELRGEKIDIIPWSEDPARFACNALQPAAVSKVYIDEENKALEIIVADDQLSLAIGKKGQNVRLAAKLTGWRIDIKSETRAAEAELLEFSSYDGATEEAPQEPVEESEAQPLEQGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VC7</accession>
    <name>Q39VC7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511500.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31797">
        <property type="protein sequence ID" value="ABB31797"/>
        <property type="gene ID" value="Gmet_1565"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1565"/>
    <dbReference type="eggNOG" id="ENOG502ZF7T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_171729_0_0_7"/>
    <dbReference type="OMA" id="FAPCCIS"/>
    <dbReference type="OrthoDB" id="2036092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223166" evidence="1">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="105" mass="11266" checksum="BDD97E1DACFC845E" modified="2005-11-22" version="1">MKRKISYGIVAALVLMYGGVSYAASCGSCGDDAKCKDPQAVQQFKSKTAHLRKSLNEKEIELSVEYGMNSIDTNRTTALENQIGDLKKEIGAAGEKLGFAPCCIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VG8</accession>
    <name>Q39VG8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl:(R)-benzylsuccinate coenzyme A transferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bbsF</name>
        <name evidence="1" type="ordered locus">Gmet_1522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511545.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1522"/>
    <dbReference type="DNASU" id="3740122"/>
    <dbReference type="EnsemblBacteria" id="ABB31756">
        <property type="protein sequence ID" value="ABB31756"/>
        <property type="gene ID" value="Gmet_1522"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1522"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_2_0_7"/>
    <dbReference type="OMA" id="DILIMNF"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="409" mass="45069" checksum="42F52619A802A9F7" modified="2005-11-22" version="1">MLPNLKKALDGIVVCDFSWVGAGPIATNVLGQCGAEVIKIESKSRPDLLRTGGPFKDGINEGLERSGYFANRNPNKKGIALDMSHPKARAVAVRLIRKSDIVINNFRVGQMEKWGLGWEDVRKINPRIIYVTMSLQGETGPQKSYMGFGVNLNALCGLTAQACFPGERPFGTGTNYTDHVMAPSHTLFGIMAALLEREQTGEGQTVAISQLKSAISMAPTSAMTYAANGDTLGPAGLSDPNAAPHGLFTTLGYRRWIAIAVFSEDEWRALKKVMGNPAWAEDGKFGSLQSRKENEAELNEHMEAWTSRQHADKIMDELLRNGVRAGVVNDARGAIEDDHLREREFWSYLDHPVMGRTLYNRAPIRLSKTPLRMETAAPLLGQHTRDVLKGMLDYTDEEIAMLSEEKVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VT6</accession>
    <name>Q39VT6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511663.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1404"/>
    <dbReference type="EnsemblBacteria" id="ABB31638">
        <property type="protein sequence ID" value="ABB31638"/>
        <property type="gene ID" value="Gmet_1404"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1404"/>
    <dbReference type="eggNOG" id="COG3014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011615_5_2_7"/>
    <dbReference type="OMA" id="PCACCAV"/>
    <dbReference type="OrthoDB" id="1249425at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="517"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="571" mass="64720" checksum="D5FDDDC247C929AC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W12</accession>
    <name>Q39W12_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514700.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1327"/>
    <dbReference type="EnsemblBacteria" id="ABB31562">
        <property type="protein sequence ID" value="ABB31562"/>
        <property type="gene ID" value="Gmet_1327"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1327"/>
    <dbReference type="eggNOG" id="ENOG503364T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645192_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="411" mass="47866" checksum="11CD281ACE8AF612" modified="2005-11-22" version="1">MRDTVIIFCKCMNMGGTETLTIRLLNWYRQNNYRSILLTLDEITSMTLLEDIKKINIEHYVYNHNKREFYSCKSNKLTFNSKDNCLIITHFMPEFFECFSMLTESKYSCKFRHTIYIVHPYSTYMVSKKIAFIGKGLIDYLLKKNVIVFMDETCIEKCVNYYGLIPEEYDLTVLRLPISVNCENIIANRNKIFNILTVSRFEFPFKGYVIGLIKSFEKLYTVNNNISLTIIGYGEGKDSVLRAIRDMQPVVAEKISVIDQVPYSKLNEYILKSDVFVGMGTTILDAAQMSKICIVAIAYQMSDHAAGFLHDNYKNIGEIYDKSNNYPSIYNLLNKALDFNNDEFKYYSDYTYRIIKECYNIDVIAPKLWQNTSYLFTINAYLLVKLLAALNVLITLIAKKFIKREYNANGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W30</accession>
    <name>Q39W30_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoacid:ferredoxin oxidoreductase, thiamin diphosphate-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">vorB</name>
        <name evidence="2" type="ordered locus">Gmet_1308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512058.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1308"/>
    <dbReference type="EnsemblBacteria" id="ABB31544">
        <property type="protein sequence ID" value="ABB31544"/>
        <property type="gene ID" value="Gmet_1308"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1308"/>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_2_1_7"/>
    <dbReference type="OMA" id="LPTIFCP"/>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="51"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="247" mass="26764" checksum="5426C83E7A5766C1" modified="2005-11-22" version="1">MQQVFKKPVSLKDVQTHFCPGCHHGTFHRLVAEAMDEFGVQKRTIGVASVGCSVFLYGYFDIDVVEAPHGRAPAVATGVKRARPDAFVFTYQGDGDLAAIGTSEIIHAANRGEDMTVIFVNNTTYGMTGGQMAPTTLVGQRTSTSPYGRNQGKDGAPIRMAELLAQLEGVAFSARVAVNNPKNLMDAKRQIKKAFRYQAEGKGFSFIEALSSCPTNWGMDPIKANERVGTEMCAYFPLGVFKNAADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W39</accession>
    <name>Q39W39_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365800.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1299"/>
    <dbReference type="EnsemblBacteria" id="ABB31535">
        <property type="protein sequence ID" value="ABB31535"/>
        <property type="gene ID" value="Gmet_1299"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1299"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045809_0_0_7"/>
    <dbReference type="OMA" id="DIYNAGS"/>
    <dbReference type="OrthoDB" id="1287359at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NosD" evidence="1">
        <location>
            <begin position="243"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="445" mass="47027" checksum="C5538B5BEA235DDC" modified="2005-11-22" version="1">MRRSTMATMRMPLALSVLLGMAAVLGGCGTVSELFARGKTLVSPSSAQVSVPVVAPGATVANEESPPVPLAPSPENKPAVVPPQVIPALPGISRIAPRMAVPVERLYNDAVLTEDTVWSGEVFVEGSLTVAPQTTLTLEPGTVVRFRRTVPGDGAGPLLLVQGRLVVRGNADAPVRFTTSFPDPLAGEWQGIILLGSEKKNLLEQCRIEGAVAGIDASFSSVTLKQVFFAACGTGARFQDSIVTVSGGEASDNAVGMELVESESDIRDMVVRDNRLGMTVRGGSLLLEGAGLTDNRETGLTGVASRLSMSGSFFQGNGTGIVLTDCEGKVTGTRIAENRHVGIHLVRSRVRVYGNEIVSNADIGLRVEDGQGVAWGNAFSGNGRFDIENAGRDDFRAIANWWGDPSPPLDMRLDLQAQNPARGRIFVNPVLKARPYFPTLNSVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W72</accession>
    <name>Q39W72_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock DNA/RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512101.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39W72"/>
    <dbReference type="STRING" id="269799.Gmet_1266"/>
    <dbReference type="EnsemblBacteria" id="ABB31502">
        <property type="protein sequence ID" value="ABB31502"/>
        <property type="gene ID" value="Gmet_1266"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1266"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_3_7"/>
    <dbReference type="OMA" id="IWQKERG"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="66" mass="7107" checksum="90EDAE86AFA55097" modified="2005-11-22" version="1">MAQGKVKWFNDAKGFGFIEQENGEDVFVHFSAIQSDGFKTLAEGEAVTFDVVTGPKGLQAANVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-02-10" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WC6</accession>
    <name>Q39WC6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyceraldehyde-3-phosphate dehydrogenase, type I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gapB</name>
        <name evidence="4" type="ordered locus">Gmet_1211</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512159.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1211"/>
    <dbReference type="EnsemblBacteria" id="ABB31448">
        <property type="protein sequence ID" value="ABB31448"/>
        <property type="gene ID" value="Gmet_1211"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1211"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_1_1_7"/>
    <dbReference type="OMA" id="SDLWYDK"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="3">
        <location>
            <begin position="131"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="481" mass="52733" checksum="B67BD5521BF89CE1" modified="2005-11-22" version="1">MNNQMQVTYLKEWQHLEECAECMLPLIGKLYREHNVVTTVYGRTLVNSTTIDILKSHRFARLILDDELSVLDTFPIVEAMTRLDLAPARVDIGKLTVRYKAEGSGIGVDDFARRELASVNTGRSPILSEPRDVVLYGFGRIGRLLARILVEKAGSGEKLRIRAAVVRKGGADDLAKRASLLRRDSVHGHFNGIITFDEQENAIIANGNMIRIIYADAPENVDYTQYGIKNAILIDNTGKWRDRDGLGRHLKAKGIDKVILTAPGKGDIPNIVAGINNELITPDEHIFSAASCTTNAIVPVLKAVNDRFGIVSGHVETCHSYTNDQNLIDNYHKASRRGRSAPLNMVITETGAAKAVAKALPELTGKLTGNAIRVPTPNVSLAILNLELGQEASVAEINGYLRQISLDSALQNQIDYTNSSEVVSSDFVGSRHAGVVDSLATISQGKRCVLYVWYDNEFGYSCQVVRMVQKMAGVELPSVPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WD3</accession>
    <name>Q39WD3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Murein hydrolase-controlling membrane protein LrgB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lrgB</name>
        <name evidence="6" type="ordered locus">Gmet_1204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512166.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1204"/>
    <dbReference type="EnsemblBacteria" id="ABB31441">
        <property type="protein sequence ID" value="ABB31441"/>
        <property type="gene ID" value="Gmet_1204"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1204"/>
    <dbReference type="eggNOG" id="COG1346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082099_0_1_7"/>
    <dbReference type="OMA" id="AQFVHFM"/>
    <dbReference type="OrthoDB" id="1416872at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007300">
        <property type="entry name" value="CidB/LrgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30249">
        <property type="entry name" value="PTHR30249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04172">
        <property type="entry name" value="LrgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="239" mass="25368" checksum="65FF885DA679512C" modified="2005-11-22" version="1">MSAEMQQVWVYLSTSPLLWLTLTLIAYQIGTWVFRRLDCPPLLNPVLTAIILLVVLLKVSGIDYQTYFRGAQFIHFLLGPATVALAIPLYREMEVIRKSFIPILITLAVGSVAAIISAVGIVWALGGETIILLSVAPKSVTTPIAMGISEQIGGLPSLTAVVVVLTGITGAVGGDFILNLLRIKDDNARGMALGVASHGIGTAHAIQKSRMAGAFSALAMALNGLFTALLLPVLVHLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WE4</accession>
    <name>Q39WE4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512177.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1193"/>
    <dbReference type="EnsemblBacteria" id="ABB31430">
        <property type="protein sequence ID" value="ABB31430"/>
        <property type="gene ID" value="Gmet_1193"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1193"/>
    <dbReference type="eggNOG" id="ENOG502Z964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005209_0_0_7"/>
    <dbReference type="OMA" id="VYLRRPW"/>
    <dbReference type="OrthoDB" id="732410at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1251" mass="136189" checksum="85ED2D970D2F94EB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WF6</accession>
    <name>RNY_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease Y</fullName>
            <shortName evidence="1">RNase Y</shortName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rny</name>
        <name type="ordered locus">Gmet_1180</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endoribonuclease that initiates mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase Y family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513446.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39WF6"/>
    <dbReference type="SMR" id="Q39WF6"/>
    <dbReference type="STRING" id="269799.Gmet_1180"/>
    <dbReference type="EnsemblBacteria" id="ABB31418">
        <property type="protein sequence ID" value="ABB31418"/>
        <property type="gene ID" value="Gmet_1180"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1180"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028328_1_0_7"/>
    <dbReference type="OMA" id="PHAILGM"/>
    <dbReference type="OrthoDB" id="1012190at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00335">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017705">
        <property type="entry name" value="Ribonuclease_Y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022711">
        <property type="entry name" value="RNase_Y_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF15">
        <property type="entry name" value="PTHR12826:SF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12072">
        <property type="entry name" value="RNase_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03319">
        <property type="entry name" value="RNase_Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000344881" description="Ribonuclease Y">
        <location>
            <begin position="1"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="3"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="210"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="2">
        <location>
            <begin position="336"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01175"/>
        </source>
    </evidence>
    <sequence length="520" mass="57741" checksum="9FFD92FF4B8D2827" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WK1</accession>
    <name>Q39WK1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CIS_tube domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513399.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1135"/>
    <dbReference type="EnsemblBacteria" id="ABB31373">
        <property type="protein sequence ID" value="ABB31373"/>
        <property type="gene ID" value="Gmet_1135"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1135"/>
    <dbReference type="eggNOG" id="ENOG502ZC5H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1281395_0_0_7"/>
    <dbReference type="OMA" id="WKFTAEI"/>
    <dbReference type="OrthoDB" id="1682012at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045361">
        <property type="entry name" value="CIS_tube_prot_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19266">
        <property type="entry name" value="CIS_tube"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CIS_tube" evidence="1">
        <location>
            <begin position="23"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="212" mass="22881" checksum="63C03EE40122A6D7" modified="2005-11-22" version="1">MLNTVKGMLIEYALSLPPLVLAFDFNPQSLTRSRTITLRTGSAPGTRGGYDFALPTETARVAQGVTVQPESFTIEILLDATDRMNDGDPIATQFGIEPELDTLRTMVEPKAQGPGGLQTLASLGLGGQRAFQRSESASVLLLVWGTHILPVFLTSIRVTEEAHLPSLVPYRARASLTMQVIEGNNPFYQVEKVRQVVGAALNTGRTVIGGIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WS6</accession>
    <name>Q39WS6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513233.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1058"/>
    <dbReference type="EnsemblBacteria" id="ABB31298">
        <property type="protein sequence ID" value="ABB31298"/>
        <property type="gene ID" value="Gmet_1058"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1058"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="PTNSRVM"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="146"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="462" mass="51600" checksum="2E9520840F385458" modified="2005-11-22" version="1">MKARILICDDEEGIRRYLQKMFLAKEYDVETFADGTSLLARIEGGTEGDADILLQDVRMPDMDGIEVLKRVKKLRPAMPVVVMTAFGTIDAAVEAIKLGAYDYVTKPFPKEKILGLMENALQLDLLMKENRVLKEELSRPDIPDNIVFTSAKFREVYDLTVQVAGSDANILVLGESGTGKELIAGAIHVNSQRKGRRFLSINCAALSDTLLESQLFGHVRGAFTGAITTQKGLLEEADGGTLFLDEIGDVSAAVQAKLLRVIQEREFIPVGATKPKSVDIRFVAATNKDLAKEVAAGRFREDLYYRLNVITIALPPLRERREDIEPLAMHFLAKYARRIRKNIRGFTPEALQSLQGYRWPGNVRELENVVERAAILTRGDLVTPEVLPIRPREDAPLLRPDNLLVSLEEMEREHIERVLRQTGFHKSRTAEILGISRKTLDRKIVEYALAIPGQGISGTLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WW4</accession>
    <name>Q39WW4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ferredoxin, Rieske superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513189.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1018"/>
    <dbReference type="EnsemblBacteria" id="ABB31260">
        <property type="protein sequence ID" value="ABB31260"/>
        <property type="gene ID" value="Gmet_1018"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1018"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_3_7"/>
    <dbReference type="OMA" id="YAIDDSC"/>
    <dbReference type="OrthoDB" id="1681886at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="5">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="98" mass="10802" checksum="D8CDC60A29667B2E" modified="2005-11-22" version="1">MQFAAKLAEVPLWGKKLVTVSGEEVVLINDKGKIYACENYCPHQGSPMLAGIVKDGVIACPRHGWHYKLADGGCTDFPDYTLKTYRVEVVGDDIMIDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WX8</accession>
    <name>Q39WX8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Formate dehydrogenase formation protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fdhE</name>
        <name evidence="1" type="ordered locus">Gmet_1004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513174.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1004"/>
    <dbReference type="EnsemblBacteria" id="ABB31246">
        <property type="protein sequence ID" value="ABB31246"/>
        <property type="gene ID" value="Gmet_1004"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1004"/>
    <dbReference type="eggNOG" id="COG3058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071015_1_0_7"/>
    <dbReference type="OMA" id="RIKCAYC"/>
    <dbReference type="OrthoDB" id="876348at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16341">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024064">
        <property type="entry name" value="FdhE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006452">
        <property type="entry name" value="Formate_DH_accessory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37689">
        <property type="entry name" value="PTHR37689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04216">
        <property type="entry name" value="FdhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144020">
        <property type="entry name" value="SSF144020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="280" mass="30411" checksum="FE3B0F7DE6FE6A55" modified="2005-11-22" version="1">MPRAAEKKAFVDTLCRENPEYTEVLAIFSELYAAIEGKEGETGLTVTLPESPAADRLRDGVPLISFDAIAVDREKALAFIGTVIDVMQRMGNDGGESLERLRAALAEGEADLLALLRGVLAHERRVILETALAVRIDPGLVEFAFHTPLRVALEQVAEGVDPGLYAGWNKHFCPVCGSPAAMAELVGDEGERHLSCSTCFSRWTYNQPNCPFCGNDDPEQLTHFTTGEGPHRVDICLACSQYLKTRLSPTGSAGVPPEQDDLATVLLDLLAAQEGYRRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X18</accession>
    <name>Q39X18_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus minor pilin PilV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilV-2</name>
        <name evidence="2" type="ordered locus">Gmet_0964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514358.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0964"/>
    <dbReference type="EnsemblBacteria" id="ABB31206">
        <property type="protein sequence ID" value="ABB31206"/>
        <property type="gene ID" value="Gmet_0964"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0964"/>
    <dbReference type="eggNOG" id="COG4967">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1935031_0_0_7"/>
    <dbReference type="OMA" id="LAFINMS"/>
    <dbReference type="OrthoDB" id="2152613at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="13946" checksum="5078F4B8E9381A4E" modified="2005-11-22" version="1">MKAVANNGLFFRSNAGFSLLEALIAIAILSVVMLGTASMLFTGMSGSLGSNNRYVATATAQSRIEALMNTPFASLASQLTPITTVSNGISYNTKWQVNNLTSNLAFINMSTTWTDKNGRHGMNFSVVRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X25</accession>
    <name>Q39X25_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor diguanylate cyclase/phosphodiesterase, GAF domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514440.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0957"/>
    <dbReference type="EnsemblBacteria" id="ABB31199">
        <property type="protein sequence ID" value="ABB31199"/>
        <property type="gene ID" value="Gmet_0957"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0957"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_7"/>
    <dbReference type="OMA" id="PQWQTIR"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="226"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="1">
        <location>
            <begin position="369"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="633" mass="71004" checksum="B47176A58F167096" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X87</accession>
    <name>NTPPA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dTTP/UTP pyrophosphatase</fullName>
            <shortName evidence="1">dTTPase/UTPase</shortName>
            <ecNumber evidence="1">3.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside triphosphate pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nucleotide pyrophosphatase</fullName>
            <shortName evidence="1">Nucleotide PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_0895</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dTTP + H2O = diphosphate + dTMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28534"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + UTP = diphosphate + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:29395"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="3.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Maf family. YhdE subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513042.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X87"/>
    <dbReference type="SMR" id="Q39X87"/>
    <dbReference type="STRING" id="269799.Gmet_0895"/>
    <dbReference type="EnsemblBacteria" id="ABB31137">
        <property type="protein sequence ID" value="ABB31137"/>
        <property type="gene ID" value="Gmet_0895"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0895"/>
    <dbReference type="eggNOG" id="COG0424">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040416_2_1_7"/>
    <dbReference type="OMA" id="RIDGDFY"/>
    <dbReference type="OrthoDB" id="1469203at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036218">
        <property type="term" value="F:dTTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035529">
        <property type="term" value="F:NADH pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036221">
        <property type="term" value="F:UTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00555">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="PTHR43213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02545">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00172">
        <property type="entry name" value="maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000267312" description="dTTP/UTP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="site" description="Important for substrate specificity" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00528"/>
        </source>
    </evidence>
    <sequence length="192" mass="20395" checksum="3E3395B2E95E2216" modified="2005-11-22" version="1">MPENSRIVLASASPRRLELLASAGIEFDVFASDIPEEPIPGEAPADFSVRLAKDKAVATAARSEGRWFIGADTIVVCDGEIMGKPADGADAVRMLKKLSGVPHEVITGYAIYDKARDGILCKAVVTKVFFKPLRDEEITAYVATGCPMDKAGAYAIQGGAACMVERIDGSYTNVVGLPLCEVVEDLRTMGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XH5</accession>
    <name>Q39XH5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514394.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0807"/>
    <dbReference type="EnsemblBacteria" id="ABB31049">
        <property type="protein sequence ID" value="ABB31049"/>
        <property type="gene ID" value="Gmet_0807"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0807"/>
    <dbReference type="eggNOG" id="COG1600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061526_0_0_7"/>
    <dbReference type="OMA" id="CATGPCA"/>
    <dbReference type="OrthoDB" id="1478472at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="270" mass="29588" checksum="4C6B3256877E491A" modified="2005-11-22" version="1">MEEALRAEIGRFVAESPENRFPDGSGPYFDDPLVGFAAADDPLFTDYKHIIGDFHLTPAELLDGAATVIVWILPIVEGTRMSNRLETEWPSRKWAFTRSHGETLNGALRRHLVAHLEGIGHRAVVPQYAPAWKEFADTPVGIASTWSERHAAYAAGLGTFSLSDGLITARGIAHRVGSVITDLVLPPSPRTTPDHRHNCLWYREETCGVCIGRCPVGAITFNGHDKSRCRDYVYGAVPEAVGERYGVTHTGCGLCQTRVPCESAIPRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XH6</accession>
    <name>Q39XH6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0806</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514393.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0806"/>
    <dbReference type="EnsemblBacteria" id="ABB31048">
        <property type="protein sequence ID" value="ABB31048"/>
        <property type="gene ID" value="Gmet_0806"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0806"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_10_13_7"/>
    <dbReference type="OMA" id="LINAAFM"/>
    <dbReference type="OrthoDB" id="626204at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="11"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="396" mass="41491" checksum="7D39E6B35F52D115" modified="2005-11-22" version="1">MESREHRAGKLLLLACVISFVCFFGSYMRIPIVPLFATSLGADTAQVGLINSAFMLMAGALSIPSGLVSDRLGRRIPLLGGLILLAGSSFLLYWSNTPLQMGGVYLLFGIGLSAFSPTLMSYVADVTPPEVLGQAYGWYTMALYGGMTLGPAAGGFLGTALGLRPVFLVAGGLILAMFVVALIFLPAPSSAQHRSAVRPAILPTLAGLMHNRRLVACLVATLGTCFGFGMFVTFMPLYIRSQGMHSGHVGFVFAAQALANAISRLPSGKLSDRVADRSILVTGGLAIFALALASFGLCRSVVPLMGAAAVMGISMGVAFTAVCALIADVVPREQRGLAMGCYNTCVYVGMMLCAAGMGAFIREEGFRIGFFLNGVVGVATLLLFVTLYRRPEPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XK0</accession>
    <name>Q39XK0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor diguanylate cyclase/phosphodiesterase, S-box-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0782</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513527.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0782"/>
    <dbReference type="EnsemblBacteria" id="ABB31024">
        <property type="protein sequence ID" value="ABB31024"/>
        <property type="gene ID" value="Gmet_0782"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0782"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_7"/>
    <dbReference type="OMA" id="FCFYSAQ"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="332"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="2">
        <location>
            <begin position="474"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="736" mass="82248" checksum="21032E01EC8D32D0" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XQ1</accession>
    <name>Q39XQ1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514448.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0731"/>
    <dbReference type="EnsemblBacteria" id="ABB30973">
        <property type="protein sequence ID" value="ABB30973"/>
        <property type="gene ID" value="Gmet_0731"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0731"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_7"/>
    <dbReference type="OMA" id="NTYGWEF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="105"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="167"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="242"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="323"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="536" mass="60649" checksum="2BFA2DCA2EC8BCDC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YC3</accession>
    <name>Q39YC3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0508</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512204.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30751">
        <property type="protein sequence ID" value="ABB30751"/>
        <property type="gene ID" value="Gmet_0508"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0508"/>
    <dbReference type="eggNOG" id="ENOG502ZY1Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2934944_0_0_7"/>
    <dbReference type="OMA" id="GMLEIYV"/>
    <dbReference type="OrthoDB" id="2064407at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="59" mass="6698" checksum="0A28FBB675F97C2A" modified="2005-11-22" version="1">MVKFYDPMDRADQARVEAILRGKGIEYFLLPEPQEGIGPQQIHVAEEDLPFAEALLRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YD3</accession>
    <name>Q39YD3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512194.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0498"/>
    <dbReference type="EnsemblBacteria" id="ABB30741">
        <property type="protein sequence ID" value="ABB30741"/>
        <property type="gene ID" value="Gmet_0498"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0498"/>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120432_0_0_7"/>
    <dbReference type="OMA" id="RDWPYLY"/>
    <dbReference type="OrthoDB" id="1983082at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="21"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="201" mass="22737" checksum="A62C1A6BA3A79D69" modified="2005-11-22" version="1">MDWGKYKLELCTGPAVIPHLSEIARLRITIFEEYPYLYKGSREIETKYLRAYADTPDACVFVVRDGDAIIGAGTGVPLHGEPATFTAPFAGSPFSLDTIYYLGEVLFLPGYRGQGLGSRLLKEFEEHIRSLGRYRHLACATIERPEDHPLRPGDYHPIDGYLIKAGFIRHPELSVTLPWPNLEGEVTDNTMVFWVKELEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YD9</accession>
    <name>Q39YD9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Divalent manganese/zinc ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0492</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512188.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0492"/>
    <dbReference type="EnsemblBacteria" id="ABB30735">
        <property type="protein sequence ID" value="ABB30735"/>
        <property type="gene ID" value="Gmet_0492"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0492"/>
    <dbReference type="eggNOG" id="COG1121">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_11_7"/>
    <dbReference type="OMA" id="GEYADRM"/>
    <dbReference type="OrthoDB" id="1721927at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="6"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="256" mass="27994" checksum="A60F0508FD3B7F29" modified="2005-11-22" version="1">MSVGVVTVQGLSHAYQGVDALLDVSFAVEKGSYVGIVGPNGSGKSTLVRCILGLARPDRGRVDLFGTPLASFDQWQRVGYLPQGLQHFNPHFPATVAEVVGLGLLANRSFPRRVHREDAGAVGRALELMGIGGIRNRLIGELSGGLRQRVLLARAMVNGPELLVLDEPTTALDPETREIFYRTIQELNRERKTTIILVTHDSGTIGRYASSLLYLDKRLVFYGGFDDFCGSPEMGDFFGSHSQHLICHRHQDGAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YI9</accession>
    <name>Q39YI9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fliC</name>
        <name evidence="6" type="ordered locus">Gmet_0442</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30685.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365667.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0442"/>
    <dbReference type="EnsemblBacteria" id="ABB30685">
        <property type="protein sequence ID" value="ABB30685"/>
        <property type="gene ID" value="Gmet_0442"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0442"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011142_2_2_7"/>
    <dbReference type="OMA" id="FEHTINN"/>
    <dbReference type="OrthoDB" id="636786at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042187">
        <property type="entry name" value="Flagellin_C_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00207">
        <property type="entry name" value="FLAGELLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flagellin_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="5">
        <location>
            <begin position="190"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30685.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="275" mass="28433" checksum="3C18C75CA79C1626" modified="2012-10-31" version="2">MALTVNTNVASLNAQRNLASTQVSLNQSLQRLSSGLRINSAADDAAGLAISEGMKAKIRSMNQAVRNANDGVSLVQTAEGALNEVSNILGRMRELSTQAATGTLTTAQRSYINGEFQQLRSEITRIAAATTFNGTNLLSSAKTIKIQIGTGNSSFDKLSIALSSMNASNALLVRGSIGGASGGIAQAMLATLDTAIDKVSKTRAGLGAIQNRLQSTINNLQVAVENTSAAQSRIADADIASETAAMTRANILTQAGTSILAQANQAPQTALSLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YK6</accession>
    <name>Q39YK6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0425</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0425"/>
    <dbReference type="EnsemblBacteria" id="ABB30668">
        <property type="protein sequence ID" value="ABB30668"/>
        <property type="gene ID" value="Gmet_0425"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0425"/>
    <dbReference type="HOGENOM" id="CLU_2522815_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="84" mass="9553" checksum="087B11E5092EBAC4" modified="2005-11-22" version="1">MPSGATWHSELFRRFCSPSLIPLPVLFDDAQALALAPYRKFRHFVYHSYGFQADWERMAEGIDNLGGALGAFKSRLDLYLNTLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YM2</accession>
    <name>MRAY_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phospho-N-acetylmuramoyl-pentapeptide-transferase</fullName>
            <ecNumber evidence="1">2.7.8.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-pentapeptide phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraY</name>
        <name type="ordered locus">Gmet_0409</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine = di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UMP</text>
            <dbReference type="Rhea" id="RHEA:28386"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="EC" id="2.7.8.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 4 family. MraY subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.13" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512381.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YM2"/>
    <dbReference type="SMR" id="Q39YM2"/>
    <dbReference type="STRING" id="269799.Gmet_0409"/>
    <dbReference type="EnsemblBacteria" id="ABB30652">
        <property type="protein sequence ID" value="ABB30652"/>
        <property type="gene ID" value="Gmet_0409"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0409"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_0_0_7"/>
    <dbReference type="OMA" id="LMSPLHH"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051992">
        <property type="term" value="F:UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06852">
        <property type="entry name" value="GT_MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00038">
        <property type="entry name" value="MraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003524">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10555">
        <property type="entry name" value="MraY_sig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00445">
        <property type="entry name" value="mraY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01347">
        <property type="entry name" value="MRAY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000235452" description="Phospho-N-acetylmuramoyl-pentapeptide-transferase">
        <location>
            <begin position="1"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00038"/>
        </source>
    </evidence>
    <sequence length="358" mass="39303" checksum="5962E8FB09E149DB" modified="2005-11-22" version="1">MLYHLLYPLASDFRIFNVFKYLTFRTIYAVITALLVSFILGPWVIRKLEALQARQVIRTDGPESHLKKSGTPTMGGILILASIVIPTLLWADLTNRYVWTTLFVIVGYGLIGFTDDYKKVVEKNPKGLSPRQKMAGQLLIAGMAVCFLVFVVNMSTELAFPFFKRLHPDLSWFYIPFAMLVIVGASNAVNLTDGLDGLAIGPVAINAATYLLFTYIAGNAKLSSYLQTPYVPGAGELAVLCGAMVGAGIGFLWYNAYPAEVFMGDVGSLSLGGGLGTLAVITKQEILLVIVGGVFVVEALSVIFQVGSYKYRGKRIFRMAPIHHHFELKGVAEPKIIVRFWIITIILALVAISTLKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YZ4</accession>
    <name>Q39YZ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">D-alanyl-D-alanine carboxypeptidase-related and peptidoglycan-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513996.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0285"/>
    <dbReference type="EnsemblBacteria" id="ABB30530">
        <property type="protein sequence ID" value="ABB30530"/>
        <property type="gene ID" value="Gmet_0285"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0285"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_952357_0_0_7"/>
    <dbReference type="OMA" id="GARNSTM"/>
    <dbReference type="OrthoDB" id="1587434at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039561">
        <property type="entry name" value="Peptidase_M15C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13539">
        <property type="entry name" value="Peptidase_M15_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M15_4" evidence="2">
        <location>
            <begin position="123"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="234"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="292" mass="32681" checksum="E94A7FE547A5645E" modified="2005-11-22" version="1">MYREKSKYSKLEGPLSNVNLNLTSARNQILFSILGKPRIDGMYGEKDGPLNNPQLEKLMVRGVDVGPFKVNGLGLAVESLKTVMADISKQHKDIYDRLSQEGMLVVRYQRPTAKKPIGCPNRPISNHSWGTAIDLKIDGLLDGRGDNKSQHALNVIAPIFNKYKWYWGGTFPTEDSMHFEVSKEKLLEWHNAGLLGPISKRLPEAKIPETTRPASTSSSSRHRSMFDWLQKGDRGPKVVQLQKALKSRGYNLKSDGVFGKKTETALQDFQRKQGLPDNGIVGPKAAAYLLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z46</accession>
    <name>Q39Z46_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513548.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0233"/>
    <dbReference type="EnsemblBacteria" id="ABB30478">
        <property type="protein sequence ID" value="ABB30478"/>
        <property type="gene ID" value="Gmet_0233"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0233"/>
    <dbReference type="HOGENOM" id="CLU_135590_1_0_7"/>
    <dbReference type="OMA" id="QPEVYVE"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223477" evidence="1">
        <location>
            <begin position="25"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="126" mass="14265" checksum="A40E0C130BCF0033" modified="2005-11-22" version="1">MYRIACGIFALTVALMVNVLPAHARGGYYGHHGGGVRFGVHVGPGAWWPGWWGPYGYGYYPYYPPPVIVQPPSDLYVEPAPAPEAEEPRYWYYCKEAKGYYPDVKKCPKGWMKVVPPENPPEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z52</accession>
    <name>Q39Z52_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein DUF445, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="DNASU" id="3739438"/>
    <dbReference type="EnsemblBacteria" id="ABB30472">
        <property type="protein sequence ID" value="ABB30472"/>
        <property type="gene ID" value="Gmet_0227"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0227"/>
    <dbReference type="eggNOG" id="COG2733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036718_2_0_7"/>
    <dbReference type="OMA" id="PGWTPRF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007383">
        <property type="entry name" value="DUF445"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04286">
        <property type="entry name" value="DUF445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="419" mass="46129" checksum="D00FD6DACCBDE7C5" modified="2005-11-22" version="1">MDTRKQALIRNKTIATGLMIGAAILFVIARLQKGHGAWEWVAAFAEAAMVGALADWFAVVALFRHPLGVPIPHTAIIKNKKDAIAGNLAGFIRDKFLATDTLIAKMRAYNPAEHLAVYLMARDNAAGMARGVTRLCADSLDFIDDERVQRLLRAALSNRIDSFDVSTSAGTVLDALRKDNRHQVVLDDLLQRCAGWLAGEEAQARLATAIDDMCAKEYPLLMAFLPNRDKFARGAGEKIVKRINAFIQEVNADPGHEVRYRFDTAVTGFIARLKTDPVLRDKIEAIKRDVVHNQAISDYAQSIGSDLKNWLKNDLQQPESQVREKVAAAVAGLGTTLAHNKELQESLNAHLETLVLHYGDTLRTAIAGHITGTMQQWEHEDYTNEIELSIGSDLQFIRMNGTLVGGVIGLLLHAISLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z70</accession>
    <name>Q39Z70_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512797.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0208"/>
    <dbReference type="EnsemblBacteria" id="ABB30454">
        <property type="protein sequence ID" value="ABB30454"/>
        <property type="gene ID" value="Gmet_0208"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0208"/>
    <dbReference type="eggNOG" id="ENOG5033PMS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709502_0_0_7"/>
    <dbReference type="OMA" id="CNPKPEH"/>
    <dbReference type="OrthoDB" id="632672at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="387" mass="44751" checksum="48D4E40F3A520722" modified="2005-11-22" version="1">MVQIIDKKVNLEYALGHHLHCMIAQVPNRIRRAEKGFAVMEPDRQWEAVRSILDLVAGGEGNLKKLHFLMLPETHVPVVRFDEMLRIIDGTFRPNSVTMFGVEHVSLKAYREMLERFREDNAEAIELVDRDIDSGDVLEMPVNWCCVAVKEATGKLRVFLEAKSHPFHGEEFLDKFHDLYRGRHFYLFRSRPSCFNFMVLICLDYLYRDLYSSNIRQIIDHANQLYFSTRQTLDTIFVVQCNPKPEHRAYRDVLSGFYGEYLEDTPGVRETVTVFGNTSDETRIEDAPEDRGFGCSSVVINRRHRLARVQLSEFSTDDFGGAPVCRLRFGTGTRLYYFNLPLHHELDPRTTRVPLKVHTIMRPSPDGGWVRVSGDEMVAEFEIGQEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z82</accession>
    <name>CINAL_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CinA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_0196</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CinA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512785.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z82"/>
    <dbReference type="SMR" id="Q39Z82"/>
    <dbReference type="STRING" id="269799.Gmet_0196"/>
    <dbReference type="EnsemblBacteria" id="ABB30442">
        <property type="protein sequence ID" value="ABB30442"/>
        <property type="gene ID" value="Gmet_0196"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0196"/>
    <dbReference type="eggNOG" id="COG1058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030805_9_2_7"/>
    <dbReference type="OMA" id="PGVPYEM"/>
    <dbReference type="OrthoDB" id="1834406at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00885">
        <property type="entry name" value="cinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00226_B">
        <property type="entry name" value="CinA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041424">
        <property type="entry name" value="CinA_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008135">
        <property type="entry name" value="Competence-induced_CinA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18146">
        <property type="entry name" value="CinA_KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006728">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="SSF142433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00200">
        <property type="entry name" value="cinA_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00199">
        <property type="entry name" value="PncC_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000058709" description="CinA-like protein">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00226"/>
        </source>
    </evidence>
    <sequence length="413" mass="43545" checksum="A0A02CAF4ED8089F" modified="2005-11-22" version="1">MKTALLSIGDELLLGEVVDTNSARIAARLADEGIVTARKLTVGDDEGEIAGALEELARGHDVVIATGGLGPTDDDVTARAAARATGRRLVLNEEAMGHLREFFVRLGREMHPANGRQCLLPAKAELIPNPTGTASGFYLPLDRCLLMFLPGVPSEMAVMLDETVVPLVLERRGEHRRTRTLTLTVFGLSEAEIGARLSDLDRSRPGLTVAYCVEYPVVQVKLRATGEDEGALTALLEDGAALVRERLGGHVVAGDGETIDTTVARLFRETGMTLALAESCTGGLIAGRVTAIPGSSAYFFLSAVTYANDAKARLLGVPQGLLAETGAVSAEVAKAMARGARQLAGSDLALAVTGIAGPEGGSPDKPVGTVFIALADQAGCSAKGYHFRGDRDRIRTITAVTAMDWLRRRLLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z96</accession>
    <name>Q39Z96_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S1 RNA-binding domain-containing transcriptional accessory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tex</name>
        <name evidence="3" type="ordered locus">Gmet_0182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512770.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0182"/>
    <dbReference type="EnsemblBacteria" id="ABB30428">
        <property type="protein sequence ID" value="ABB30428"/>
        <property type="gene ID" value="Gmet_0182"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0182"/>
    <dbReference type="eggNOG" id="COG2183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009833_0_2_7"/>
    <dbReference type="OMA" id="RWAWRTR"/>
    <dbReference type="OrthoDB" id="120764at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05685">
        <property type="entry name" value="S1_Tex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041692">
        <property type="entry name" value="HHH_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044146">
        <property type="entry name" value="S1_Tex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018974">
        <property type="entry name" value="Tex-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032639">
        <property type="entry name" value="Tex_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006641">
        <property type="entry name" value="YqgF/RNaseH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17674">
        <property type="entry name" value="HHH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09371">
        <property type="entry name" value="Tex_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16921">
        <property type="entry name" value="Tex_YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00732">
        <property type="entry name" value="YqgFc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="649"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="719"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="757" mass="83282" checksum="220E7613D27EBAC3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZG2</accession>
    <name>Q39ZG2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514118.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30362">
        <property type="protein sequence ID" value="ABB30362"/>
        <property type="gene ID" value="Gmet_0113"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0113"/>
    <dbReference type="HOGENOM" id="CLU_2093358_0_0_7"/>
    <dbReference type="OMA" id="PERMFIK"/>
    <dbReference type="OrthoDB" id="1859897at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="120" mass="13607" checksum="B023FA7F7C544E18" modified="2005-11-22" version="1">MTGREIEKEIRDGRKADQPFIKWCRKENDFVDYELVNSFLASVGSGDEFASYELLTMDQMWNVLKEFDPKGVSRGEKGGEEVIFWEQTLADGTTKNRACPYTPDSLISVFDAVTKGNPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZH6</accession>
    <name>Q39ZH6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">efp-1</name>
        <name evidence="7" type="synonym">efp</name>
        <name evidence="11" type="ordered locus">Gmet_0099</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514104.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0099"/>
    <dbReference type="EnsemblBacteria" id="ABB30348">
        <property type="protein sequence ID" value="ABB30348"/>
        <property type="gene ID" value="Gmet_0099"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0099"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_2_0_7"/>
    <dbReference type="OMA" id="RWRTTEQ"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="69"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="131"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="187" mass="20861" checksum="6DB701F1B0439CEC" modified="2005-11-22" version="1">MLTTSDFKRGLVIKLDGAPCVILDVHFQSPSARGASTMVKTKYRNLLTAQVLEKTFRSGDKVEEADFERHKGQFLYADGDRGVFMDLETYEQFEMDADSFSAIQPYLLDGTEVTLGLFQERLVSVDPPQVVELTVTDTPPIMKNATATAQTKEATLETGLTLQVPPYLEVGEKIKVDTRDCRFVSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZH8</accession>
    <name>Q39ZH8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0097</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365625.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0097"/>
    <dbReference type="EnsemblBacteria" id="ABB30346">
        <property type="protein sequence ID" value="ABB30346"/>
        <property type="gene ID" value="Gmet_0097"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0097"/>
    <dbReference type="eggNOG" id="COG4269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049287_0_0_7"/>
    <dbReference type="OMA" id="FRIWIVN"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010295">
        <property type="entry name" value="DUF898"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05987">
        <property type="entry name" value="DUF898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="421" mass="46787" checksum="4E1F939B100D3F53" modified="2005-11-22" version="1">METVSCPHCGFAKEMPAGTVPNGARVKCPRCKETFIFTRTADRGTPPAAVTAARESAAVVPPLSAPSEPRRPAQPRTLRFTFTGTAKEYFGIWIVNTLLKIVTLGVYSAWAKVRKRRYFYGNTLLDGSPFDYLADPKALFRGWLIGVLAFLVYTAGTRYTPGISKILGSIFFLTVPWLVVRSRLFNNRNSSYRSLRFAFRDDYQEAYVIFAGLAFLVPFTLGLIFPYLIYRQKKFLVERSSFGRTPFTFTATGKDYYVLFLKAAGWLVLLLVVVMPAAFYVISTLAEGGALLAGGDLHRTQMMVGALMIFTLPFLYFFIVVYVQTALANLTWNSTGIAGSSFVSRMRVRDMAWLYLSNAVAIMGSLGLMIPWASVRLARYRFETLSVEGIADMEAFRAGFQGDVSATGEEIGDIFGIDVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZJ0</accession>
    <name>Q39ZJ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein tyrosine/serine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514741.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0085"/>
    <dbReference type="EnsemblBacteria" id="ABB30334">
        <property type="protein sequence ID" value="ABB30334"/>
        <property type="gene ID" value="Gmet_0085"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0085"/>
    <dbReference type="eggNOG" id="COG2365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086657_1_0_7"/>
    <dbReference type="OrthoDB" id="1972497at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004861">
        <property type="entry name" value="Siw14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03162">
        <property type="entry name" value="Y_phosphatase2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="SSF52799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223538" evidence="3">
        <location>
            <begin position="24"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="61"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="TYR_PHOSPHATASE_2" evidence="5">
        <location>
            <begin position="121"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="202" mass="21888" checksum="9625A5A5D06A0B69" modified="2005-11-22" version="1">MTSITIRPTIVACLIIALGAGSAVGSAVTGQTPAAQPQASVTLPPEARLSERIYHLPGISNGGRVAPGIYRGAQPGPEGYETLRKMGIRTVIDLRTTESEQREVEAAGMKAIAIPIAMSRDGLREKVDRVVVLMADPANQPVFVHCRHGQDRTGIVVAAYRMKVEGWSLADAEAEMQSFGFNDVWINFKKFIKSYGEQLPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZK6</accession>
    <name>Q39ZK6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response receiver-modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0069</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514193.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0069"/>
    <dbReference type="EnsemblBacteria" id="ABB30318">
        <property type="protein sequence ID" value="ABB30318"/>
        <property type="gene ID" value="Gmet_0069"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0069"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_28_7"/>
    <dbReference type="OMA" id="PRMDGYK"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="4">
        <location>
            <begin position="172"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="314" mass="35697" checksum="E8B4C6D292F9DE47" modified="2005-11-22" version="1">MKKTVLVIDDSDTLREEILRSLRGVSLFDTYLEAGDGLDGFKVLLNNRVDLVLCDLEMPRMDGFRFLTMMRAREEFQDLPVIILTGREDRDTKIRGLEQGASDFVTKPFDTGELVARVRVQLKMKGLQDELKRSNEMLRTLSITDPLTHLHNRRHLMEMVDKEFQRSSRKGAPLSLVILDIDYFKKINDTYGHQEGDRVLTILADIVRRRLRSYDLAARYGGEEFVLLLPETPVQEALSIAERLRLEVQEHVFEGSLGGLVITISLGVATYPSSRVESIDSLFRQADEALYRAKQGGRNRVELMAGASIEKGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-02-10" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZL1</accession>
    <name>Q39ZL1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIM barrel protein, AP endonuclease family 2/xylose isomerase-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514188.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0064"/>
    <dbReference type="EnsemblBacteria" id="ABB30313">
        <property type="protein sequence ID" value="ABB30313"/>
        <property type="gene ID" value="Gmet_0064"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0064"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050006_7_1_7"/>
    <dbReference type="OMA" id="HIHDNMG"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="3">
        <location>
            <begin position="37"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="256" mass="28935" checksum="C73998832F49D7CE" modified="2005-11-22" version="1">MSNCVYAHVPYSMLAANLPAIISRRINPEIFFSGDTLDTLVPEEVGAIAGQLAEAGLRCTFHGAFIDLNPGSVERLIREATMHRFGQVLDAAQILKPDVIVFHPGYDKWRYGESQDKWLAHSIVAWRQVLERTDSLGTTIAVENIFEEEPSTLKALFEAIDHPRLRHCFDVGHWNLFHTVGMEEWFAELGSFVAEAHIHDNFGKRDDHLPLGEAAIDFDLFFSLMERYAPGAAWTIEAHCRDALDRALVAIEKYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZM6</accession>
    <name>Q39ZM6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-ribose pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nudF</name>
        <name evidence="2" type="ordered locus">Gmet_0048</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514172.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0048"/>
    <dbReference type="EnsemblBacteria" id="ABB30298">
        <property type="protein sequence ID" value="ABB30298"/>
        <property type="gene ID" value="Gmet_0048"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0048"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062658_5_2_7"/>
    <dbReference type="OMA" id="DYQVHPG"/>
    <dbReference type="OrthoDB" id="1831818at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="173" mass="18750" checksum="DF279886FBCFD227" modified="2005-11-22" version="1">MDTRNRTTPFKGLVVDIEQMDVRIGDKGWHTFQVVRHPGGVGVLPLHDDGTVTLIRQLRPSVDATLLEIPAGRLDPGEEPAACGLRELAEETGLSSTRLESLGVILTSPGVFDEAIHLYLATGLSQGEADPEQYEEIETVRVPLEEAVTMATDGRIRDGKTIIALFRAKAGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZR2</accession>
    <name>Q39ZR2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fgrL</name>
        <name evidence="8" type="ordered locus">Gmet_0012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513777.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0012"/>
    <dbReference type="EnsemblBacteria" id="ABB30262">
        <property type="protein sequence ID" value="ABB30262"/>
        <property type="gene ID" value="Gmet_0012"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0012"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_57_7"/>
    <dbReference type="OMA" id="DFSCIHL"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="7"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="299"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="246"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="561" mass="63157" checksum="9A55E6488C6928AE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>J7LW88</accession>
    <name>J7LW88_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3590"/>
    <dbReference type="EnsemblBacteria" id="AFR42805">
        <property type="protein sequence ID" value="AFR42805"/>
        <property type="gene ID" value="Gmet_3590"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3590"/>
    <dbReference type="HOGENOM" id="CLU_2568992_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="81" mass="8610" checksum="F6874CFDB78A8FFD" modified="2012-10-31" version="1">MGGGGMGGAMGCPGSGTDPDRWTTTGVRPWIAACAAAWEAVAAWAETAKPWPPCSRRRKWTRTAPPWDFSLGPRWTTSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-06-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>J7M0A0</accession>
    <name>J7M0A0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3607"/>
    <dbReference type="EnsemblBacteria" id="AFR42827">
        <property type="protein sequence ID" value="AFR42827"/>
        <property type="gene ID" value="Gmet_3607"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3607"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3356398_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="176" mass="19982" checksum="3E3FE790CDAD7B5C" modified="2012-10-31" version="1">MSSIQLFTRNSRYYHLQWIPPDLRSLHGERVEPVKPPLKTADRKQAQGLASGRYQKYTVTSSLLRSGLLAPDQTPDPLAEDSPKKRKDQAEAVNHDVSPPRPHPKPLAQLFIEEHSPSVPPGLNRNILLPVKEKSRRYKLKFNDNCCATRQKVQNALQKVPQKEVDDKEKGVNHIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PS5</accession>
    <name>NADA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Quinolinate synthase</fullName>
            <ecNumber evidence="1">2.5.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadA</name>
        <name type="ordered locus">Gmet_3544</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dihydroxyacetone phosphate + iminosuccinate = H(+) + 2 H2O + phosphate + quinolinate</text>
            <dbReference type="Rhea" id="RHEA:25888"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29959"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="2.5.1.72"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:25889"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from iminoaspartate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the quinolinate synthase family. Type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.72" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513700.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39PS5"/>
    <dbReference type="SMR" id="Q39PS5"/>
    <dbReference type="STRING" id="269799.Gmet_3544"/>
    <dbReference type="EnsemblBacteria" id="ABB33749">
        <property type="protein sequence ID" value="ABB33749"/>
        <property type="gene ID" value="Gmet_3544"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3544"/>
    <dbReference type="eggNOG" id="COG0379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047382_0_0_7"/>
    <dbReference type="OMA" id="CFCSTMN"/>
    <dbReference type="OrthoDB" id="613347at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00327"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008987">
        <property type="term" value="F:quinolinate synthetase A activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10800">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00568">
        <property type="entry name" value="NadA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003473">
        <property type="entry name" value="NadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036094">
        <property type="entry name" value="NadA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023066">
        <property type="entry name" value="Quinolinate_synth_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30573">
        <property type="entry name" value="PTHR30573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02445">
        <property type="entry name" value="NadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142754">
        <property type="entry name" value="SSF142754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00550">
        <property type="entry name" value="nadA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000061155" description="Quinolinate synthase">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>iminosuccinate</name>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00568"/>
        </source>
    </evidence>
    <sequence length="304" mass="33381" checksum="D3A352920595D3E7" modified="2005-11-22" version="1">MQADTIKQEIRRLLKERNAVLLAHNYMRDEVQEIADITGDSLGLSQEAAKTAADVIVFCGVHFMAESASILSPHKTVLLPRRDAGCPMADMVTVEGLLELKARHPGVPVVTYVNSSAAVKAVSDICCTSANAVKVVNSLPDREVIFVPDRNLGQFVAKQSDKAFHFWDGYCPTHERLKADVVARLKAENPDALFICHPECNPAVVALADHACSTSGMYDYCRKSPAKRFIIGTEAGILYKLRLENPDKEFILASPALVCPNMKLTSLEDILDALTTMAPVVQVPEDIRVQAKRALDRMIAIPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PT9</accession>
    <name>Q39PT9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA 2',3'-cyclic phosphodiesterase</fullName>
            <shortName evidence="2">RNA 2',3'-CPDase</shortName>
            <ecNumber evidence="2">3.1.4.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11828"/>
            <dbReference type="Rhea" id="RHEA-COMP:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:17353"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:83064"/>
            <dbReference type="ChEBI" id="CHEBI:173113"/>
            <dbReference type="EC" id="3.1.4.58"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2H phosphoesterase superfamily. ThpR family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.58" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513686.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3530"/>
    <dbReference type="EnsemblBacteria" id="ABB33735">
        <property type="protein sequence ID" value="ABB33735"/>
        <property type="gene ID" value="Gmet_3530"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3530"/>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081251_0_1_7"/>
    <dbReference type="OMA" id="HITLRFL"/>
    <dbReference type="OrthoDB" id="1696971at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004113">
        <property type="term" value="F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008664">
        <property type="term" value="F:2'-5'-RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01940">
        <property type="entry name" value="RNA_CPDase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014051">
        <property type="entry name" value="Phosphoesterase_HXTX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004175">
        <property type="entry name" value="RNA_CPDase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35561">
        <property type="entry name" value="PTHR35561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02834">
        <property type="entry name" value="LigT_PEase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02258">
        <property type="entry name" value="2_5_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="LigT_PEase" evidence="3">
        <location>
            <begin position="92"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 1" evidence="2">
        <location>
            <begin position="36"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HXTX 2" evidence="2">
        <location>
            <begin position="120"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="184" mass="20102" checksum="950C7DE1384FB7FF" modified="2005-11-22" version="1">MRLFVAIDLPDEVKRSVADICRGVPGVRWLPPDQLHLTLRFIGEEDDAVAAAIRRGLAEITSPPFPLSLQGVGCFPSPRRPRVLWVGLSGGAPLQQLQQKVEAAMVAAGILAEERPFSPHITLARLREHREGDVAPFLARNASFHCEPFTVDAFHLYSSILAAKGAIHRHEASYPLAGRMETAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PV6</accession>
    <name>Q39PV6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3513</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513669.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33718">
        <property type="protein sequence ID" value="ABB33718"/>
        <property type="gene ID" value="Gmet_3513"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3513"/>
    <dbReference type="HOGENOM" id="CLU_989589_0_0_7"/>
    <dbReference type="OMA" id="EIGYRIN"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004222971" evidence="1">
        <location>
            <begin position="20"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="253" mass="27548" checksum="BBC69E5EDBCFB01A" modified="2005-11-22" version="1">MRLVLTVCVLVCLAASAWAGETEVFLKSGYFDWKETVSDKGVIRERGLVSGAGIAYTGFVGERVFIRPSLEVWGGNVDYRGFQVGTWAPLEGDTTYFGTTEEVRVGLKLPVGEAFSVSPFAVLGHKFWLRSLSVEDWNSFYGRIGVRGATKHLFAEGGVTLPVYTRVHTDWSSDGYNDFVTEPKNKPSAFAEAGATFGQWRIGVFYEQMEFGQSDTVRVEKSSGSAGAVLVASGAFQPDSVAHHVGLKVGFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PW8</accession>
    <name>Q39PW8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513657.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3501"/>
    <dbReference type="EnsemblBacteria" id="ABB33706">
        <property type="protein sequence ID" value="ABB33706"/>
        <property type="gene ID" value="Gmet_3501"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3501"/>
    <dbReference type="HOGENOM" id="CLU_189842_1_1_7"/>
    <dbReference type="OMA" id="WLVAIPQ"/>
    <dbReference type="OrthoDB" id="2010921at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223130" evidence="2">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="77" mass="7992" checksum="6D0D137820A7A7EF" modified="2005-11-22" version="1">MRARTAAGTLALVMGSVTSALAASGAREDNSGVFVWIFLGFCALIIVAQMVPAVLTMLGMAKGVKESFGEKAEVKSR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q57</accession>
    <name>ATPE_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase epsilon chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector epsilon subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase epsilon subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpC</name>
        <name type="ordered locus">Gmet_3405</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text>F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514212.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Q57"/>
    <dbReference type="SMR" id="Q39Q57"/>
    <dbReference type="STRING" id="269799.Gmet_3405"/>
    <dbReference type="EnsemblBacteria" id="ABB33617">
        <property type="protein sequence ID" value="ABB33617"/>
        <property type="gene ID" value="Gmet_3405"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3405"/>
    <dbReference type="eggNOG" id="COG0355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084338_1_3_7"/>
    <dbReference type="OMA" id="AWGFVEV"/>
    <dbReference type="OrthoDB" id="1696893at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020547">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="PTHR13822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00401">
        <property type="entry name" value="ATP-synt_DE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="SSF51344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01216">
        <property type="entry name" value="ATP_synt_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000265818" description="ATP synthase epsilon chain">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00530"/>
        </source>
    </evidence>
    <sequence length="138" mass="15198" checksum="D077CBFED02559FD" modified="2005-11-22" version="1">MAEKLKVDLVTPYKKILSEEVDEITATGALGEFSVLPGHAPFLTSLKIGELTYKKGGQFFHLAVNWGYFEVEDDKVTVLVETAERADEIDLERAKAALGRAEAALKGLSPEDKSYKTQEAALERALIRMQVAGKSTRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-13" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QB4</accession>
    <name>NUOH2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit H 2</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit H 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit H 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoH2</name>
        <name type="ordered locus">Gmet_3348</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33560.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512574.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QB4"/>
    <dbReference type="SMR" id="Q39QB4"/>
    <dbReference type="STRING" id="269799.Gmet_3348"/>
    <dbReference type="EnsemblBacteria" id="ABB33560">
        <property type="protein sequence ID" value="ABB33560"/>
        <property type="gene ID" value="Gmet_3348"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3348"/>
    <dbReference type="eggNOG" id="COG1005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_1_7"/>
    <dbReference type="OMA" id="MYVGMGI"/>
    <dbReference type="OrthoDB" id="1559067at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00667">
        <property type="entry name" value="COMPLEX1_ND1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000240075" description="NADH-quinone oxidoreductase subunit H 2">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <sequence length="346" mass="38483" checksum="76CB80CB429F071C" modified="2013-07-24" version="2">MGYEILGLPMAYYIAMVLKVLVVFVFVLLTVAYATYAERKIIGHMQVRLGPMRTGWHGLLQPIADGVKLFFKEEIIPSKADKFAFLIAPLIALVPAFIGFAVIPFGETIEVGGYKIPLQIAAYYDTASGQVVDLNVGVLYILALASIGVYGIVLAGWSSNSKYSLLGGLRSSAQMISYELAAGLAIISVFMLSESLSLQKIVADQANGAWYAFKQPLAFILFFICSIAEINRTPFDLPEAETELVSGFCTEYSSMKYAMFFMAEYANMVTVCAVTTTLFLGGWHGPSFLPGWFWFIAKVYFLIFTCMWIRATYPRYRYDQLMRLGWKVFLPLTLINIVVTGIIVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QB9</accession>
    <name>Q39QB9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH dehydrogenase I, M subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoM-1</name>
        <name evidence="6" type="ordered locus">Gmet_3343</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512569.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3343"/>
    <dbReference type="EnsemblBacteria" id="ABB33555">
        <property type="protein sequence ID" value="ABB33555"/>
        <property type="gene ID" value="Gmet_3343"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3343"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_4_7"/>
    <dbReference type="OMA" id="GHMGFVL"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="132"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="519" mass="57260" checksum="D6E95AB7F59AD0A4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QC9</accession>
    <name>Q39QC9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Periplasmically oriented, membrane-bound [NiFe]-hydrogenase, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hyaS</name>
        <name evidence="14" type="ordered locus">Gmet_3332</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512556.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3332"/>
    <dbReference type="EnsemblBacteria" id="ABB33545">
        <property type="protein sequence ID" value="ABB33545"/>
        <property type="gene ID" value="Gmet_3332"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3332"/>
    <dbReference type="eggNOG" id="COG1740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046107_0_0_7"/>
    <dbReference type="OMA" id="RYHETIM"/>
    <dbReference type="OrthoDB" id="798037at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009375">
        <property type="term" value="C:ferredoxin hydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.480.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027394">
        <property type="entry name" value="Cytochrome-c3_hydrogenase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037148">
        <property type="entry name" value="NiFe-Hase_small_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001821">
        <property type="entry name" value="NiFe_hydrogenase_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30013">
        <property type="entry name" value="PTHR30013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14720">
        <property type="entry name" value="NiFe_hyd_SSU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000310">
        <property type="entry name" value="NiFe_hyd_ssu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00391">
        <property type="entry name" value="hydA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0574">Periplasm</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="12">
        <location>
            <begin position="73"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="NiFe_hyd_SSU_C" evidence="13">
        <location>
            <begin position="238"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB33545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="379" mass="40186" checksum="23024AFBAB81982C" modified="2005-11-22" version="1">MAKNGDEHDEMKQHCSGTSGPWEERGVSRRDFLKFCTAMSAALALPVSLAPRIAEALESDSRPSVIWLEFQSCTGDTEALLRAANPTVGEIVLDVLSIDYAETIMAAAGHQAEEARLKTLKERSGKYIAVVEGAIPMKDNGVYCCVGGRSAVDIAREVCGGAMATITVGTCASYGGIPAASPNPTGAVGVKDAVPGATVINLPGCPVNTDNLVATVVHILTFGKLPATDSKGRPLFAYGKRIHDNCERRPHFDAGQYVEQWGDQAHRAGHCLYKMGCKGPETFHNCPTQRYNEKTSWPVGSGHGCAGCSEPHFWDTMTPFYRRLPSVPGFGIEATADKIGLGVAAATAAVFGIHGVVSALRKGDESDGEGGVDHGQDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QD7</accession>
    <name>Q39QD7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyl-accepting chemotaxis sensory transducer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mvhV</name>
        <name evidence="5" type="ordered locus">Gmet_3324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512548.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3324"/>
    <dbReference type="EnsemblBacteria" id="ABB33537">
        <property type="protein sequence ID" value="ABB33537"/>
        <property type="gene ID" value="Gmet_3324"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3324"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_535021_0_0_7"/>
    <dbReference type="OMA" id="KTRGNDW"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="HAMP" evidence="4">
        <location>
            <begin position="145"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="202"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="534" mass="57125" checksum="127F6C5DD7AED50A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QH1</accession>
    <name>Q39QH1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-methylcrotonyl-CoA carboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mccB</name>
        <name evidence="3" type="ordered locus">Gmet_3290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512513.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3290"/>
    <dbReference type="EnsemblBacteria" id="ABB33503">
        <property type="protein sequence ID" value="ABB33503"/>
        <property type="gene ID" value="Gmet_3290"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3290"/>
    <dbReference type="eggNOG" id="COG4799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018822_0_1_7"/>
    <dbReference type="OMA" id="AYLPIMS"/>
    <dbReference type="OrthoDB" id="123223at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="PTHR22855"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="268"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="535" mass="57734" checksum="2AFDF9F095131A96" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QJ9</accession>
    <name>Q39QJ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3262</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33475.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512700.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3262"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33475">
        <property type="protein sequence ID" value="ABB33475"/>
        <property type="gene ID" value="Gmet_3262"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3262"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065765_4_4_7"/>
    <dbReference type="OMA" id="NVDRKPH"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLT" evidence="3">
        <location>
            <begin position="139"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33475.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="257" mass="27055" checksum="613B867C28FF1F46" modified="2012-10-31" version="2">MIIDTLINRSTPSESKPQTDRPTVREAGAGLVFDEFLAAGTGIDVQPGARASAAAAAELMRLDMMRSAFTLGDSEGGGNPPAMGRAVEFMLKSFAENSREPVDPASPVAAGGSSAAPVASAAPEPLPAKGSGNWLDDVVNRASRRHGVEVGLIKAVIKAESNFNPNAVSPVGAQGLMQLMPATAKGLGVTNSFDPEQNVMAGTKFLKDLLARYGGNVDKALAAYNWGPGNVDRKPHLLPRETREYLAKVKDYYNQYA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QM8</accession>
    <name>HEM1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA reductase</fullName>
            <shortName evidence="1">GluTR</shortName>
            <ecNumber evidence="1">1.2.1.70</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemA</name>
        <name type="ordered locus">Gmet_3233</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = H(+) + L-glutamyl-tRNA(Glu) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:12344"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="EC" id="1.2.1.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamyl-tRNA reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.70" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512672.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QM8"/>
    <dbReference type="SMR" id="Q39QM8"/>
    <dbReference type="STRING" id="269799.Gmet_3233"/>
    <dbReference type="EnsemblBacteria" id="ABB33446">
        <property type="protein sequence ID" value="ABB33446"/>
        <property type="gene ID" value="Gmet_3233"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3233"/>
    <dbReference type="eggNOG" id="COG0373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035113_2_2_7"/>
    <dbReference type="OMA" id="FAFKCAA"/>
    <dbReference type="OrthoDB" id="1358620at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00316"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008883">
        <property type="term" value="F:glutamyl-tRNA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00087">
        <property type="entry name" value="Glu_tRNA_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000343">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015896">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015895">
        <property type="entry name" value="4pyrrol_synth_GluRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018214">
        <property type="entry name" value="GluRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036453">
        <property type="entry name" value="GluRdtase_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036343">
        <property type="entry name" value="GluRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00745">
        <property type="entry name" value="GlutR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05201">
        <property type="entry name" value="GlutR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000445">
        <property type="entry name" value="4pyrrol_synth_GluRdtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69075">
        <property type="entry name" value="SSF69075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69742">
        <property type="entry name" value="SSF69742"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01035">
        <property type="entry name" value="hemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00747">
        <property type="entry name" value="GLUTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000004625" description="Glutamyl-tRNA reductase">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="49"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for activity" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00087"/>
        </source>
    </evidence>
    <sequence length="434" mass="48227" checksum="F9AABCA63A9679CF" modified="2005-11-22" version="1">MNIVVVGLSHKTASVDIREKVAFAPTQMEKPLRALLAIEDIAEAVIVSTCNRVEVYISTRDIAGGMARIKRFLADYHGISPEILEPHLYAHHGEAAIRHVFRVASSLDSMVVGEPQILGQIKTAYGYAAEFKTSGIILNRFLHKAFSVAKRVRTETKIASSAVSVSFAAVELARKIFGNLSDKTVMLIGAGEMCELAAKHFINNGVRGVMVTNRTYERAVKLAEEFEGKPVSFDDLFDQLHKADIVLSSTGATQFIIKPKDVEEVIRRRKLKPMFFIDIAVPRDIDPKVNDVENVYLYDMDDLQGVVASNLQQRAEEAKKAEAIIDEEIGQFHKWLSNLEVTPTIVALRSKFEETRKAELEKTLASWKDLPPDGAKRLEALTTAIVNKLLHPPTATLKRVGQGGRTDLYVDALRTLFELQTGESEAEELGELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QN7</accession>
    <name>Q39QN7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512663.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3224"/>
    <dbReference type="EnsemblBacteria" id="ABB33437">
        <property type="protein sequence ID" value="ABB33437"/>
        <property type="gene ID" value="Gmet_3224"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3224"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672256_0_0_7"/>
    <dbReference type="OMA" id="RYLGART"/>
    <dbReference type="OrthoDB" id="1520435at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="461" mass="48828" checksum="692C030B8934D4ED" modified="2005-11-22" version="1">MVKILLIADQDRLEKLFDFVSDSPQIHFRISRSLRQGSQDIADEAPDILFVQNHLSGLSGEIIARHLIGQAEGARPRVVLFGEMAQQPPDQGPLDACLDIARTDEELTAAIIGIISELPAPPPPVEIPPSVETEEQAPAPSPAEQPVPASPATDAAPSSTEPPIPATDTVVDTFGRQGSPVPPQSMSPFDEKLTTVIEQTAEPVPLAEMEDTVHLTAGADGARSSAATRPRIGRKETKLTKLLWIGLAALAVVAVGTIMLLTPETPSPKQAPRPAARPAAPAPKKIVPTPQPPAPAAPPTAAQASSPGATAPAVTPVKIPAQPEPQRPPQAATPPHPPVGTGGGLAQLPSFIPREGRDRDYGKSNPGWERYKGARTEFKVYRDGTVIRAVQAIDRSGVGIPESFLRGALNQMSTSREFTLDSTETQGKFRVEKGTVKGGGRLVVYRTVPKGAIRAFVVHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QQ7</accession>
    <name>Q39QQ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger transcriptional regulator, TraR/DksA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_3204</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512642.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3204"/>
    <dbReference type="EnsemblBacteria" id="ABB33417">
        <property type="protein sequence ID" value="ABB33417"/>
        <property type="gene ID" value="Gmet_3204"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3204"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_3_1_7"/>
    <dbReference type="OMA" id="CIDCKEE"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="41"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="139" mass="15946" checksum="58E87ADB60088589" modified="2005-11-22" version="1">MVEKQDEMKALLLKAKEEILAGINKALKSGSETNTGEPTGDIYDQASSERDRELGLLLNDRERDKLRQIDEALLRIADGEYGICEECEEEIPLGRLKVMPFARFCVRCQSDMEKLQAQTRRVEEERSYREVSFGEEEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QT4</accession>
    <name>Q39QT4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase, family 57</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 57 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513894.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3177"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33390">
        <property type="protein sequence ID" value="ABB33390"/>
        <property type="gene ID" value="Gmet_3177"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3177"/>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005603_1_0_7"/>
    <dbReference type="OMA" id="PYTHPIL"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="2">
        <location>
            <begin position="8"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="734" mass="83275" checksum="CD19818E8C3F233F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QX9</accession>
    <name>Q39QX9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphate/sulfate transporter family membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_3131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514306.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3131"/>
    <dbReference type="EnsemblBacteria" id="ABB33345">
        <property type="protein sequence ID" value="ABB33345"/>
        <property type="gene ID" value="Gmet_3131"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3131"/>
    <dbReference type="eggNOG" id="COG0306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015355_1_1_7"/>
    <dbReference type="OMA" id="RANPHKA"/>
    <dbReference type="OrthoDB" id="1329125at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PTHR11101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="333" mass="34707" checksum="C8F9B0730959F2F6" modified="2005-11-22" version="1">MLDATLIMLVLVIGAALAFDYINGFHDTANAIATCVSTRALSVRAAIIMAAVLNFAGAMISTKVAATIGKGIVDAPNVTQMVVLAGILGAIVWDLITWYYGLPASSSHAIIGGLMGAVIAHAGTTALHWKGLEKIVLSLVLSPIVGTFLGFAVMVIMLWCFKSTSPYSINKHFRRLQVLSAAFMAFSHGTADAQKSMGVITMALVSYGALSSFVVPTWVKIACAVAMGLGTAAGGWRIIKTVGKDFVKLQPVHGFCVETASAGVILGASSIGMPVSTTHVITSAILGVGLSKRLTAVNWNVAGRIVVAWVLTIPASAIMAYVCYQVLNPILGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R39</accession>
    <name>Q39R39_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cobalt/zinc/iron/cadmium/nickel efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">dmeF</name>
        <name evidence="8" type="ordered locus">Gmet_3071</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513630.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3071"/>
    <dbReference type="EnsemblBacteria" id="ABB33285">
        <property type="protein sequence ID" value="ABB33285"/>
        <property type="gene ID" value="Gmet_3071"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3071"/>
    <dbReference type="eggNOG" id="COG1230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_0_0_7"/>
    <dbReference type="OMA" id="GHEKMLH"/>
    <dbReference type="OrthoDB" id="948593at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="302"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="334" mass="37318" checksum="6845E5ECC7B0FFA8" modified="2005-11-22" version="1">MHAETHLDQSITGRFKYAIILTTFTLVAEVAGGIWTNSLALLSDAAHVFLDLFALILSLAAIKLAGYPASDTRTFGWHRTEVFASFINGATVFLMAIGIFYEAWERLRHPVEVKSLPMLVIAAVGLVMNLVAASALHSHSHDDLNVRSAFLHVIGDAAASVGVIIGGVIMYYTSWYLLDAIISAGIGCVIFWGSWRVIRESSHILMEGVPRGMSTREVAIAMQEVEGVNTVHHLNIWTICSHILALSAHVDVEPEHKERQADVLRRLEELLFERYHISHTTLQAECTRCAETPPIIKELRHRPRHGQHHDHHGHDHGHGHDHHGHDHDHCHHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R74</accession>
    <name>Q39R74_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase RhlB</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 12" type="primary">rhlB</name>
        <name evidence="12" type="ordered locus">Gmet_3035</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family. RhlB subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514349.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3035"/>
    <dbReference type="EnsemblBacteria" id="ABB33250">
        <property type="protein sequence ID" value="ABB33250"/>
        <property type="gene ID" value="Gmet_3035"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3035"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_28_3_7"/>
    <dbReference type="OMA" id="EYCTPIQ"/>
    <dbReference type="OrthoDB" id="626183at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00661">
        <property type="entry name" value="DEAD_helicase_RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023554">
        <property type="entry name" value="RNA_helicase_ATP-dep_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="32"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="220"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="385"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="404"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="438" mass="49477" checksum="DED65062C03691CC" modified="2005-11-22" version="1">MKFTDLNLPELVQRGIADTGFTDCTPIQEKTLPLALSGKDVAGQAQTGTGKTAAFLISLFTRLLKNPTEGETRNPRALILAPTRELVVQIEKDAQALGAHCGFVIQAIYGGVDYMKQRSALKEGADVVVGTPGRLIDYLKQKVYSLKEIEVLVIDEADRMFDMGFIADLRFILRRLPPFDKRQNLMFSATLNQRVMELAYEFMNVPEKVAVTPEQMTAERVEQVLYHVGRKEKFPLLLGLLRKKGMERTMIFVNTKREAEFLDERLNANDFPCRVISGDVEQRKRMRILEDFKNGKLPIMIATDVASRGLHIDGVSHVINYDLPQDAEDYVHRIGRTARAGAEGKAISMADEDGAFHLEAIHEYIKDKIPVEWAEDDLFVHDFKRVKPKPKGHETRAKGPTRHGRKHPEGEKKEGEGEAKKRRRGPRKKPAGEKPKPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RC1</accession>
    <name>Q39RC1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine synthase</fullName>
            <ecNumber evidence="3">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysK-1</name>
        <name evidence="8" type="ordered locus">Gmet_2988</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514479.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2988"/>
    <dbReference type="EnsemblBacteria" id="ABB33203">
        <property type="protein sequence ID" value="ABB33203"/>
        <property type="gene ID" value="Gmet_2988"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2988"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_7"/>
    <dbReference type="OMA" id="EDAYEMS"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="7">
        <location>
            <begin position="12"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="5">
        <location>
            <begin position="180"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="307" mass="32180" checksum="C1C89F1F467F7103" modified="2005-11-22" version="1">MPVFDSDKVIEQIGNTPLQRLAKLEAPGSAAVYGKAEFFNPGGSVKDRICLAMIEAAEKDGSLKPGMTVVEPTSGNTGIGLSMICAIKGYKLVLTMPDTMTVERRRLLAAYGAELVLTPGAQGMRGAVQKAEELAAQPGHIMMQQFKNGANPEAHRRTTGPEIVRALSGQSIDAFVAGVGTGGTITGVGEVLKEHNAAVRIVAVEPDASPILSGGQPGPHKIQGIGAGFVPDVLNTKVYDEVIRVTNEDAYETVRRLAQEEGVLVGISSGANVFAALQVAKRLGPGKNVVTILCDTGERYLSTGVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RD9</accession>
    <name>Q39RD9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512903.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2970"/>
    <dbReference type="EnsemblBacteria" id="ABB33185">
        <property type="protein sequence ID" value="ABB33185"/>
        <property type="gene ID" value="Gmet_2970"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2970"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1223286_0_0_7"/>
    <dbReference type="OMA" id="QVTHTER"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="25"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="226" mass="24658" checksum="CCD569C2D4734DD0" modified="2005-11-22" version="1">MFQDPTDEYIRTITAHCDLAGKEVLEVGCGTGRITRDLARHARRVVAVDPDETALAKARSAVPAPNVQFLPMPDGVLHFPPASFDVVIHTLSLHHVPLDRMNESLRAAAGLVRDGGVIVVVEPGDGGSFTEAKERFGAGSGDERPGREAAIRAMHGLDGWTVGETVLFRVRFLFADEDDFIATKLPGFGEKPEAFQQEVREFLARHRTAEGVVLDAGRRLNVLRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RM2</accession>
    <name>Q39RM2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512820.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2884"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33102">
        <property type="protein sequence ID" value="ABB33102"/>
        <property type="gene ID" value="Gmet_2884"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2884"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_4_1_7"/>
    <dbReference type="OMA" id="KRIPWNG"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="298" mass="33165" checksum="97219DF72156F037" modified="2005-11-22" version="1">MKLSATIAIILLNWNGWRDTVDCVESCRKLDYPNFRIVIVDNGSTDGSEAILRERFPDVELIQTGANLGFAGGNNAGIRHALVRGADYVWLLNNDTVVEPGALGALVRVAESDPRVGMVGSKIVYFDDPWLLWFAGAVIDPERPHRPFHRGLHERDTGQYDRVAETGYVTGCSLLARREMMAEVGMLDDDLFLYFEDADWSARAARAGWKLLYVPDSVVRHKESVSSGGAASPRLVYYTARNRLYFVRRNFPAKLAAALCYDLFEHVLVNVKKGRFPLAVAGCRGIRDFLAGKIGPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RM6</accession>
    <name>Q39RM6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514611.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2880"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33098">
        <property type="protein sequence ID" value="ABB33098"/>
        <property type="gene ID" value="Gmet_2880"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2880"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028014_3_2_7"/>
    <dbReference type="OMA" id="WISITEK"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="26"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="391" mass="44201" checksum="D4A37BCF921D4A09" modified="2005-11-22" version="1">MMQARPKILALYPRLPSMARAAGEKTAFKFVETLHGLGHRIVLLSFAFNGYDEKDYQALEPLCEKIVLHPFGSGEKLANVLRGWHLSPTLAARRSPGFGRLIDEHIAGCDLVHIEFTELLPWACHISKRYPEKRVSYVAHDIVFQKKYREARRHLFLNPWRDLDLAMTWWSENRFLACTDRIIVQNRKDAALIPRHRERVRVVVPYAQTAASEESSVPPPISGRYLIYYGAMDRPENYLAAISFLRICWPELRREFPDLEFCVLGARPHDRLREFDGRDGVTVTGFVEDPNAYLSGAFLTVAPITLGAGIKVKVLESLLSGSPVVAFPAGAEGIDVGPREGLTVVEGYREMTAAIRRALHGALPDRGEIRAAARCAFDWGITESFLREDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RP3</accession>
    <name>Q39RP3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitrilase/amidohydrolase superfamily protein, class 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33081.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366113.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2863"/>
    <dbReference type="EnsemblBacteria" id="ABB33081">
        <property type="protein sequence ID" value="ABB33081"/>
        <property type="gene ID" value="Gmet_2863"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2863"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_6_7"/>
    <dbReference type="OMA" id="PTYGMFE"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33081.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="283" mass="31918" checksum="423EA4669DA58074" modified="2012-10-31" version="2">MDFIVALAQIKPKLGCLTENCTLVESAIERAVADKADLIVFPELALTGYFLRDLVPDVALRLDAPEIARIRELSRHVAIVVGFVEVSDDYRFFNSAIYVDGGEIRHIHRKVYLPTYGLFDEQRYLARGERFRAFDTRFGRMGMLICEDMWHLSAPYILAMDGATTLVCLSSSPGRGISEDESLGSTAAWQKLTSTTAMFLNSRVFYCNRVGYEDGVNFWGGSEVIAPSGSVVSRARLFDEDLLVTRVDGGELRRERIFSPMMRDESLSITMKELRRIEKGRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RS9</accession>
    <name>Q39RS9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver CheY associated with MCPs of classes 40H and 40+24H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY64H-2</name>
        <name evidence="3" type="ordered locus">Gmet_2827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513977.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2827"/>
    <dbReference type="EnsemblBacteria" id="ABB33045">
        <property type="protein sequence ID" value="ABB33045"/>
        <property type="gene ID" value="Gmet_2827"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2827"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="IVDDNEY"/>
    <dbReference type="OrthoDB" id="1862996at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="136" mass="15013" checksum="762AE2DF8DBBCBB9" modified="2005-11-22" version="1">MATDPQDTAQVVIVDDEPFIRDAVVKLLACEGIAAVAAENGDECLDLLRKGFRGIILMDVMMPRRNGWQTIRAMADESLVAGNIISMLTSVDEPDEQMEGLQELVFDYITKPFDPSEMVATVRTYLGCLEQMRGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RV3</accession>
    <name>Q39RV3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Integrase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2803</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514681.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2803"/>
    <dbReference type="EnsemblBacteria" id="ABB33021">
        <property type="protein sequence ID" value="ABB33021"/>
        <property type="gene ID" value="Gmet_2803"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2803"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_37_0_7"/>
    <dbReference type="OMA" id="KSYLYWN"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011946">
        <property type="entry name" value="Integrase_integron-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02249">
        <property type="entry name" value="integrase_gron"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="7">
        <location>
            <begin position="131"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="6">
        <location>
            <begin position="232"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="449" mass="52166" checksum="2BA45AA79A3AEFA1" modified="2005-11-22" version="1">MIQVPRDTMARFEAVLKRKGMPLGSFGDYRKWLRYYFDFSSKYPESRGRSEQVRKFLEKLRDKNQSEAQRRQAAHAISLYFEMQREEEPPQCNEIPSSPPQRSTCIVPQSPPRQRKSYYSEAGYQEKSDSPEWDEVLGKLAAEIKVRHYSRKTLKTYALWSRKFQRFLKNKPPQELSTADVKEYLTYLAVKCNVAASTQNQAFNSLLFLFRHGLKREFGELRDVPRAKKSLYVPVVLSREEIDAILKHLSHPFSLVVNLLFGCGLRLFECLQLRVRDFNFDAVVLTVHGKGKKDRTVPLPEAILPELTAQIERVKALHEKDLAAGYAGVFLDDAVEKKYPHAPKELIHQWFFPQQSLTLVEETGELRRYHLHESLLQEALYVAVRRAKIPKRVTAHTFRHSYATHLLQANYDIRTIQTKLGHASLKTTMIYTHCVPVRTVKEAKSPLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RW2</accession>
    <name>Q39RW2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase, IS110 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511669.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2794"/>
    <dbReference type="EnsemblBacteria" id="ABB33012">
        <property type="protein sequence ID" value="ABB33012"/>
        <property type="gene ID" value="Gmet_2794"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2794"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036902_1_1_7"/>
    <dbReference type="OMA" id="TIHIEIA"/>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="3">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="332" mass="37671" checksum="C40D349D3136AC12" modified="2005-11-22" version="1">MEKSITYVGLDVHKNSIEIALADWGRDNEVRHYGSVGGDLHSLDKVVRKLVSQGRELHFVYEAGPCGYEIYRHLTRQGFDCIVVAPSLIPKKSGNRIKNDRRDAEMLARLHRAGELTPVYVPHVEDEAMRDLSRAREDAKSAERKARQQLNAFLLRSGVRYSGKTLWSLAHWRWISDIKMPHPAQQITLQEYVDAVRACSERIDRFTEQIRQLVTQWRVGPVVEALQALRGVSLVVAVTTVAELGDLSRFDHPRQLMAYLGLVPSEHSSGETTKRGGITKTGNSHARRMLVEAAWSYRLPARVSRRLRDRQQSLPQPVWGSSGDGEFRGHHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RX8</accession>
    <name>Q39RX8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511683.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2778"/>
    <dbReference type="EnsemblBacteria" id="ABB32996">
        <property type="protein sequence ID" value="ABB32996"/>
        <property type="gene ID" value="Gmet_2778"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2778"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047548_1_0_7"/>
    <dbReference type="OMA" id="SCNNVFA"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transpeptidase" evidence="2">
        <location>
            <begin position="149"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="455" mass="49967" checksum="36C6DEFB4BD0AE74" modified="2005-11-22" version="1">MQDFKHLTRKRRFSFSALTGRRKDPPRNSFKRLESKGLEESKPRKKSLRVLLPVLAALIAAYPVFSSVLSGRTAVSSDQKEAQSAGKLPRDLDIYSSFRLGAGLFPQARLEGDRLVAPVPEGGRVVFAIDSTIQERVREVLTQFDVPYGVFVAIEPKSGKVLAMVSHSSVSPEWEERAFYGVYPMASLFKIITATAALEQGKVTPDTVIPFRGGLYSESARYWSSLPKRGAQEMDLTTAMGKSVNPVFGRVACDIAGRESVLRCAERYGFNHYLLPGTPVQPSRAEYPRTDNDLRLMGAGLGREVKISPIHVAVMMAAIANGGTMLAPSLVEEIRNTGNKVTYTHQPRTIRSIAAPEVTAQLTRMLSTTVTSGTSRRAFHDNHGRPRIANVNIAAKTGSINGTDPEGHYNWFAAYAPVENPQIALAALVINQDKWKIKASYLGEQALEAFFAKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RZ6</accession>
    <name>Q39RZ6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="3 8">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">pdhA</name>
        <name evidence="10" type="ordered locus">Gmet_2760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511701.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2760"/>
    <dbReference type="EnsemblBacteria" id="ABB32978">
        <property type="protein sequence ID" value="ABB32978"/>
        <property type="gene ID" value="Gmet_2760"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2760"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_5_0_7"/>
    <dbReference type="OMA" id="FGMPGVT"/>
    <dbReference type="OrthoDB" id="1248201at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043231">
        <property type="term" value="C:intracellular membrane-bounded organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:acetyl-CoA biosynthetic process from pyruvate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8 10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="E1_dh" evidence="9">
        <location>
            <begin position="20"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="325" mass="36403" checksum="F34E5A40F7900C52" modified="2005-11-22" version="1">MESKLRALLPDAELIRMYEQMVLSREFEESCAEQYTKGHITGFLHLYSGQEAVAVGATAGLHRDDYILSAYREHAQAIVRGAEPRRVMAELFGKRTGICKGKGGSMHLFDPNLSFMGGYAIVGGQFPIAVGLAFAAKFRKEGRIVACFFGDGAANQGTFHESLNWARLWELPVLFICENNSYGIGTSVERASALPDIHRRTCGYDIPSERVHGMDVIAVYEAVKWAAEWVREQNRPFLIEAITYRFRGHSMSDPGKYRSLAEVELWKSRDPIPAFANRLVEEEIATEAQLEGIKQQALVTVADAVKFAEDSPWPEDSEVWEDVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S15</accession>
    <name>Q39S15_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sphingosine/diacylglycerol kinase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511718.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2741"/>
    <dbReference type="EnsemblBacteria" id="ABB32959">
        <property type="protein sequence ID" value="ABB32959"/>
        <property type="gene ID" value="Gmet_2741"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2741"/>
    <dbReference type="eggNOG" id="COG1597">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045532_2_1_7"/>
    <dbReference type="OMA" id="VNDAYFM"/>
    <dbReference type="OrthoDB" id="869726at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045540">
        <property type="entry name" value="YegS/DAGK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19279">
        <property type="entry name" value="YegS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="SSF111331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="290" mass="30214" checksum="D9D3995DE29D04BF" modified="2005-11-22" version="1">MPRSCTLIINPTSGSYSASLVDRVTARLAAAGFSPSVLLTGGPDDAAAFAARACAEEDHPFIVAGGGDGTMNGVINGLVPGRATLAFLPLGTANVCARELGIGSVDEAVRRIIRREARPLSVGLLEGFGVSRRFFLMAGAGFDGFVVEGVLGEEKKRFGKGAYLLSALRTLSAWDGRPMEVEAAGARRSCHSVIVCNAARYGGSFVLAPGASLFEPRFRVVCVEAGRRRDYLRLALRVAAGRGAAGAGVTVFDADTVTIGGNKAVQVDGDFICHGPVTIRSLPDFARLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S31</accession>
    <name>Q39S31_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEP motif-containing protein, putative exosortase substrate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511735.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2725"/>
    <dbReference type="EnsemblBacteria" id="ABB32943">
        <property type="protein sequence ID" value="ABB32943"/>
        <property type="gene ID" value="Gmet_2725"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2725"/>
    <dbReference type="HOGENOM" id="CLU_996623_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223466" evidence="1">
        <location>
            <begin position="33"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="279" mass="29364" checksum="B061C759E40F0E61" modified="2005-11-22" version="1">MNGKMKSFTSKALAIAAGMVVLVLVQSNPTQASTLQVGVTVYDTADPTNFYSRVIVDNGAGDLDPNPHAILLGNNFEPIPGFVVQGSYHTAHLEPNILTSASSSVTNTRGTTSRAFVVVSDTDFKPPTNATFVTGSGTWTNAAGSTIALGYYNDPNNGQYAAPFVPFDTLGNPNPAPVLFADFDSFDQGWASLLSGDLVASFSDTATSDHDSFGFNGGPYGVSNVDPFSMALMFDFSVVPNGMLTSRGLSMEADPIPEPSTFLLLGAGLGGVVWLRRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S79</accession>
    <name>Q39S79_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2677</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511784.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2677"/>
    <dbReference type="EnsemblBacteria" id="ABB32895">
        <property type="protein sequence ID" value="ABB32895"/>
        <property type="gene ID" value="Gmet_2677"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2677"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="HPRYQNT"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042981">
        <property type="term" value="P:regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001875">
        <property type="entry name" value="DED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50168">
        <property type="entry name" value="DED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="11"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="DED" evidence="8">
        <location>
            <begin position="161"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="188"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="127"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="395" mass="44764" checksum="ABA7ED969323100E" modified="2005-11-22" version="1">MTTVTNASKGTILIIDDEKVILDLTSIVLSNRGYTVYTAPDAMVGLEELEEHHPSLVLLDYMMPVMDGFTALKQIRQRFPDTYVIMFTGKGNEEIAVELMKAGASDYILKPFNNQDLVERIESVLRIRAVELRNRELMAERDKLLAEIAEWNRELEERVREKTEALQKAQAEIVQSEKLASLGYLSAGMAHEIRNPLNSINLFAQLLKSGCEEPEKLDYIDKILKEVDRIDDIMRKLLDASKRPRFQLSEVRLDRVIDATLEVFRPQTTLYGIEVVRAFRRVPPPFQADPSEIEQIFTNLFLNAIHEMQEGGTLAVLLDHDDREVIIRISDTGRGMPPDNVKKIFDPFFTTKTSGSGLGLAVVLRIVKTYQGKITVEKSDETGTTFAIRLPLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S92</accession>
    <name>Q39S92_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain iron-sulfur cluster-binding oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2664</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511797.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2664"/>
    <dbReference type="EnsemblBacteria" id="ABB32882">
        <property type="protein sequence ID" value="ABB32882"/>
        <property type="gene ID" value="Gmet_2664"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2664"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_2_7"/>
    <dbReference type="OMA" id="PYCYASS"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="4"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="383" mass="42529" checksum="4D48906A87919E78" modified="2005-11-22" version="1">MNGAYTLECAVWEFTLACNLNCIHCGSSAGSRRTDELTTDEAVALCHDLKEAGCLGVALMGGEPLLRKDFWQIAGLIRKLGMELSVITNGTIHDPEIFARLRELDPRAVAVSLDAATPAIHDHIRGRSGAFRETWDFIRAAGEAGLPVSVITTVHRMNLTELTALREQLLRKNVAWQIQVAGAEGRRFPRELLLDEEEFYSVGLFIASTRKAYPIHAMPVIGAHDMGYHSLMLDNISLTGEWTGCQAGVSVIGIQSNGNIKGCLSMDDSTIAGNVRETSVRDLWRSAGAFPYSRGFTADDAGENCRVCPHLATCKGGCNEMSLMKTGEFHNDPYCFHRIEQHIFERELRNPWYRLLLKARRRLATLGARGNEKRLRDSFLGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SD5</accession>
    <name>Q39SD5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gnd</name>
        <name evidence="6" type="ordered locus">Gmet_2620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2012-03" db="PDB data bank">
            <title>The crystal structure of 6-phosphogluconate dehydrogenase from Geobacter metallireducens.</title>
            <authorList>
                <person name="Zhang Z."/>
                <person name="Chamala S."/>
                <person name="Evans B."/>
                <person name="Foti R."/>
                <person name="Gizzi A."/>
                <person name="Hillerich B."/>
                <person name="Kar A."/>
                <person name="Lafleur J."/>
                <person name="Seidel R."/>
                <person name="Villigas G."/>
                <person name="Zencheck W."/>
                <person name="Almo S.C."/>
                <person name="Swaminathan S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS)</scope>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511841.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="4E21">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B=1-336"/>
    </dbReference>
    <dbReference type="PDBsum" id="4E21"/>
    <dbReference type="SMR" id="Q39SD5"/>
    <dbReference type="STRING" id="269799.Gmet_2620"/>
    <dbReference type="EnsemblBacteria" id="ABB32839">
        <property type="protein sequence ID" value="ABB32839"/>
        <property type="gene ID" value="Gmet_2620"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2620"/>
    <dbReference type="eggNOG" id="COG1023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024540_0_0_7"/>
    <dbReference type="OMA" id="NGYALMY"/>
    <dbReference type="OrthoDB" id="1245550at2"/>
    <dbReference type="UniPathway" id="UPA00115"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004849">
        <property type="entry name" value="6DGDH_YqeC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="PTHR11811"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00872">
        <property type="entry name" value="gnd_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6PGD" evidence="5">
        <location>
            <begin position="184"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="4E21"/>
        </source>
    </evidence>
    <sequence length="336" mass="36594" checksum="40465FF98227A6BB" modified="2005-11-22" version="1">MQIGMIGLGRMGADMVRRLRKGGHECVVYDLNVNAVQALEREGIAGARSIEEFCAKLVKPRVVWLMVPAAVVDSMLQRMTPLLAANDIVIDGGNSHYQDDIRRADQMRAQGITYVDVGTSGGIFGLERGYCLMIGGEKQAVERLDPVFRTLAPGIGAAPRTPGREKREGTAELGYLHCGPSGAGHFVKMVHNGIEYGLMAAYAEGLNILHHANAGKEGQGADAETAPLRNPDFYRYDLDLADITEVWRRGSVISSWLLDLSATALLDSPDLQEFQGRVSDSGEGRWTVAAAIDEGVPAHVLSSALYERFSSRGEDDFANRLLSAMRYEFGGHREKS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SM1</accession>
    <name>CMOA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxy-S-adenosyl-L-methionine synthase</fullName>
            <shortName evidence="1">Cx-SAM synthase</shortName>
            <ecNumber evidence="1">2.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cmoA</name>
        <name type="ordered locus">Gmet_2532</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>prephenate + S-adenosyl-L-methionine = 3-phenylpyruvate + carboxy-S-adenosyl-L-methionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:51692"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cx-SAM synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32753.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366068.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SM1"/>
    <dbReference type="SMR" id="Q39SM1"/>
    <dbReference type="STRING" id="269799.Gmet_2532"/>
    <dbReference type="EnsemblBacteria" id="ABB32753">
        <property type="protein sequence ID" value="ABB32753"/>
        <property type="gene ID" value="Gmet_2532"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2532"/>
    <dbReference type="eggNOG" id="COG4106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078475_0_0_7"/>
    <dbReference type="OMA" id="MIELYYL"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01589">
        <property type="entry name" value="Cx_SAM_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005271">
        <property type="entry name" value="CmoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF2">
        <property type="entry name" value="PTHR43861:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006325">
        <property type="entry name" value="MeTrfase_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00740">
        <property type="entry name" value="TIGR00740"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000314331" description="Carboxy-S-adenosyl-L-methionine synthase">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="65"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01589"/>
        </source>
    </evidence>
    <sequence length="244" mass="26928" checksum="045397EFF83A5E5C" modified="2013-07-24" version="2">MTHKTDAIYAAPLQKMIDFQFDERVVAVFPDMIQRSVPGYGMIISNIGIVAAKYAQAGSHCYDLGCSLGAVSLAMRQRITQPDCDIIAVDNSPAMIARGRELLALDTAPTVPVTMICADLQEVAIENASVVVLNFTLQFIPPAERLALLERIHAGLRPGGVLILSEKIAFGEPGRQQFHEELHHDFKRANGYSDLEISQKRSALEKVLIPETLACHHERLQAAGFSFSELWFQCFNFASLVAMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SR4</accession>
    <name>Q39SR4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2485"/>
    <dbReference type="EnsemblBacteria" id="ABB32710">
        <property type="protein sequence ID" value="ABB32710"/>
        <property type="gene ID" value="Gmet_2485"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2485"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093172_0_0_7"/>
    <dbReference type="OMA" id="IYEWMAG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="48"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="252" mass="28679" checksum="453EBF850F307EE1" modified="2005-11-22" version="1">MSYIRDHYENLLADHYSWLFGSFEARATENERFFAAHGITPQGNRRAIDLGAGSGFQSIPLARAGFQVTAIDLSPKLLVELNMRRDELSIMTVEDDLLNFPRHLQGKAELCVCMGDTLTHLDNREAVEKLCRLAFVALEEKGRLVLTFRDLTTALEGLDRFIPVRNDADKIFTCFLEYELEHVKVHDLIYEKIDSGWNLRKSFYRKCRVPFTWTKEILAAVGFNLRLFSRICGDTGVLASRQVCDIAPLAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ST1</accession>
    <name>Q39ST1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512432.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2468"/>
    <dbReference type="EnsemblBacteria" id="ABB32693">
        <property type="protein sequence ID" value="ABB32693"/>
        <property type="gene ID" value="Gmet_2468"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2468"/>
    <dbReference type="HOGENOM" id="CLU_1041148_0_0_7"/>
    <dbReference type="OMA" id="ANREMKG"/>
    <dbReference type="OrthoDB" id="1306112at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223240" evidence="1">
        <location>
            <begin position="22"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="267" mass="27865" checksum="425E44C3A8162940" modified="2005-11-22" version="1">MIFRLLWGAVLGLLVASGAVAAGPVQTGTLNGRVLGEGENPLANGSVVLFRRGAGPPPAPDRYWLVPDYVEDLDDDGRFSVAVEAGAYYLAAIKRNNRKEIGPPKDGELFLVAADAKGMPATFTVKGGETAGAGTIAGVRPFGKETAAARPAGFTAIEGTIVDGDGKPVEGVIVFAFTSPTMVGKPLFVSERSGKEGNYLLRVAAGGVYYLKVRDVYGGGEPAEGTVYATFGGDIPSAVNVDYGDVKKGITIPVSRFERPTRKKGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SW0</accession>
    <name>Q39SW0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nikO</name>
        <name evidence="6" type="ordered locus">Gmet_2439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512461.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2439"/>
    <dbReference type="EnsemblBacteria" id="ABB32664">
        <property type="protein sequence ID" value="ABB32664"/>
        <property type="gene ID" value="Gmet_2439"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2439"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="TRIRMHQ"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005876">
        <property type="entry name" value="Co_trans_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01166">
        <property type="entry name" value="cbiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="252" mass="27329" checksum="60A67B193B81D5C2" modified="2005-11-22" version="1">MSHHIVEVKDLRHSYPDGTEALRGVSFTIHHGESVAVIGANGAGKSTLLLHLNGYLPPTAGEVRIGDTPVVRTTLAEVRRTVGMVFQDPDDQLFMPTVGEDVAFGPLNLGLPPGEVERRVAESLARVGAGHLRDKPPYRLSGGEKKRAAIATVLSMSPDILVMDEPTAGLDPFARRQLMGLLREFRHTKIFTSHDLDMVLELCERTIVLREGVVAADGPPREIFRNAELLAACRLEPPFSMQGCPVCGTGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SY5</accession>
    <name>Q39SY5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_2414</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512486.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2414"/>
    <dbReference type="EnsemblBacteria" id="ABB32639">
        <property type="protein sequence ID" value="ABB32639"/>
        <property type="gene ID" value="Gmet_2414"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2414"/>
    <dbReference type="eggNOG" id="COG2510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131462_2_0_7"/>
    <dbReference type="OMA" id="MQALNYI"/>
    <dbReference type="OrthoDB" id="1944417at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042221">
        <property type="term" value="P:response to chemical"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000390">
        <property type="entry name" value="Small_drug/metabolite_transptr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30561">
        <property type="entry name" value="PTHR30561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="10">
        <location>
            <begin position="53"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="126" mass="13665" checksum="51162D73775AFB56" modified="2005-11-22" version="1">MLKTFIIMLMAVSAGTIGDILLAKGMKEMGDISAMNLRGILNVAIQALTTPKLIIGTAMLAIFFFLWLAVLSWEDLSVALPMQALNYVLVAFLSQWFLGETVSPLRWTGTILVCVGVMLITKSGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SZ0</accession>
    <name>Q39SZ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Intracellular protease, PfpI family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C56 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512491.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2409"/>
    <dbReference type="MEROPS" id="C56.001"/>
    <dbReference type="EnsemblBacteria" id="ABB32634">
        <property type="protein sequence ID" value="ABB32634"/>
        <property type="gene ID" value="Gmet_2409"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2409"/>
    <dbReference type="eggNOG" id="COG0693">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_44_4_7"/>
    <dbReference type="OMA" id="YAWMREF"/>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006286">
        <property type="entry name" value="C56_PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42733">
        <property type="entry name" value="PTHR42733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01382">
        <property type="entry name" value="PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51276">
        <property type="entry name" value="PEPTIDASE_C56_PFPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="2">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="167" mass="18036" checksum="6425D9D71381448E" modified="2005-11-22" version="1">MKALIISVDQFEDSELLAPYYRLLEEGIPVDIASIHRGTITGKHGYEVQADKSLAEVNPEGYALLVLPGGKAPAAVRKEPAALEICRSFFAHNKPVAAICHGPQILISAGLLSGRRATCYQSVADEMRGAGALYEDSEVVVDGNLITSRQPSDIPAFMRELMKKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TA9</accession>
    <name>Q39TA9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514508.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2290"/>
    <dbReference type="EnsemblBacteria" id="ABB32515">
        <property type="protein sequence ID" value="ABB32515"/>
        <property type="gene ID" value="Gmet_2290"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2290"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_1_7"/>
    <dbReference type="OMA" id="YPMLRVA"/>
    <dbReference type="OrthoDB" id="1562270at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="223" mass="24075" checksum="31BC1280CF256E15" modified="2005-11-22" version="1">MLYPVNLIIFDLDGTLIDSLPDLADATNHMLSSLGRPSIGQNAVRRLVGQGARRLVERALAGASEDEINQGLDLFLDYNHRHIADRTVLYLGVPETLDALKGRGMRMAIISNKNVALCREVVSVLGIDRYFDEVLGADSLPFRKPSPEPVLKLLADFGVPPERAALVGDSINDMAAAKGARVSTVGCTWGYGELTELADADYLVESFGELFGIPLFCGGEVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TC3</accession>
    <name>Q39TC3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32501.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366028.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2275"/>
    <dbReference type="EnsemblBacteria" id="ABB32501">
        <property type="protein sequence ID" value="ABB32501"/>
        <property type="gene ID" value="Gmet_2275"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2275"/>
    <dbReference type="HOGENOM" id="CLU_1935028_0_0_7"/>
    <dbReference type="OrthoDB" id="2045773at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32501.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="14945" checksum="D6EA4F8A6D65E194" modified="2012-10-31" version="2">MNPKDLVKVWDAPDNSKLTPKQISIRLPLLVSAKINALCEIYPRKTKTEIIGDLLSTALEQLEEGMESKRGEFIEYEPTRFGRVPIYEDDGLRGVFRNRTIRNLRELESEAGITEPMPFHESVVYGEEEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TE1</accession>
    <name>Q39TE1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">etfA-3</name>
        <name evidence="10" type="ordered locus">Gmet_2257</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366012.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2257"/>
    <dbReference type="EnsemblBacteria" id="ABB32483">
        <property type="protein sequence ID" value="ABB32483"/>
        <property type="gene ID" value="Gmet_2257"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2257"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_1_1_7"/>
    <dbReference type="OMA" id="VKVCPAQ"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="442" mass="47828" checksum="5BEF70F9E336A647" modified="2005-11-22" version="1">MTEAKRPMKKPRGVAQLIAGACIACGARCQSVCPVNCVDMNDAGEPVVNSAKCIGCQKCVKICPATALEMYFTPEERKILDELAAQGDPVEEEIDPEAAALAEKLAAYRGVWVFIEQTEGEPVRVSWELLGVGKELAAKLGVELCAMVIGENVEHLCREAFAYGARKAYLVDAPVFKHYRTESYVEACCHLIAKYKPEVILMGATGMGRDLAGAVATRVSTGLTADCTGLDIDGKRNLMQTRPAFGGNIMATIMCDKFRPQMATVRPNVMPMPEHTGSTAGEIVREEFSVPEANIFTKVIEIIRDAKSKSHVDIAGADFIVSGGRGVMAPENFAMLQELADELCGVVGASRSAVDAGWMPQERQVGQTGKTVRPKIYIACGISGAIQHLVGMQDSDVVIAINRDRNAPIFEVATYGIVGDLFQIVPMLTEQIRDLKLQKNRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TF8</accession>
    <name>Q39TF8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2239"/>
    <dbReference type="EnsemblBacteria" id="ABB32466">
        <property type="protein sequence ID" value="ABB32466"/>
        <property type="gene ID" value="Gmet_2239"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2239"/>
    <dbReference type="eggNOG" id="COG1149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043380_1_0_7"/>
    <dbReference type="OMA" id="HISEEKC"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="290"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="319"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="371" mass="40820" checksum="E1F249D9FF123152" modified="2005-11-22" version="1">MGGELILSAVDDGSESLDDVYVKLRKHLDTFVLSAPEAESILGILRIRFTPEEAGAALILSQQHVEITKLAQRGNLDVNVLRPVLERMADKALVYKKNITQDGVAKELYCLLPTAVGLWETSFATGERNPRTEQLARLWQEYYKSGWGKSMLGGAPFTRVIPVGKSIDTSQEIFPYEKAAELIKRYDFAVVIHCPCRKSAELSGSSCGKVTEVCFHFGDLARFMSERGYGREVDQTEVLEILDQTEKAGLVHVVGNAKEMGVSMCSCCPCCCTQLQAIAHKPHAMAKSRFIAGVEQARCIACGLCAKRCPVRGVTSIMGPLHISEEKCIGCGLCVTTCPTQAISLKERQTYQEPFDTGRQLFAAWSQKDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TH9</accession>
    <name>Q39TH9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2218</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365974.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2218"/>
    <dbReference type="EnsemblBacteria" id="ABB32445">
        <property type="protein sequence ID" value="ABB32445"/>
        <property type="gene ID" value="Gmet_2218"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2218"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044590_0_1_7"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="10"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="304" mass="34583" checksum="1E12E9A57325A122" modified="2005-11-22" version="1">MHISRYVTFDAHVHVMSRSRLESGWRWLQQQCHDDVRTTGKPPTPKSLMADLAGSGIQGCFNFFFAIFPRTSRVVNEWNDRFCSGNAGVLPFLTLHPHDTSGERSEMLNEFILNRHFAGVKIHSFIQDIRLDAEWMHDVCAFLAKNRRILYLHTGFSATYRNRYHEEEMARDLATLLSAFPGLTVVAAHMFYPRLDLAFRLLNTFPNLYLDTTGLISTLEKGGDVGRWLPSWEEHAERIMFGSDAGLNPASILEEVRLFEELAMSEQALRRIGGETAWRLVEILGLSRDGMKLPLSPANIAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TI1</accession>
    <name>Q39TI1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2216</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365972.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2216"/>
    <dbReference type="EnsemblBacteria" id="ABB32443">
        <property type="protein sequence ID" value="ABB32443"/>
        <property type="gene ID" value="Gmet_2216"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2216"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_4_7"/>
    <dbReference type="OMA" id="RSFVRWH"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="189" mass="21664" checksum="793CFD3191AF0CB8" modified="2005-11-22" version="1">MENTYDKLITAAIELMNIEGYPGASIGMLASKVGISKSTVIHYFKSKEGILLAILENFLPGYIDAFKPVLKDPDMDGVEKLHKFLHFHMKLVVERRDVLTINLRDTKYLTGKNKVIYQNQQRLYEEQVVKIIEQIQKEGHGLFRGLKPSITAKAILGMCNYATIWYKEDDRLSIEDLAEHFFAILTRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TR9</accession>
    <name>Q39TR9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-cresol methylhydroxylase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pcmJ</name>
        <name evidence="4" type="ordered locus">Gmet_2126</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513079.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2126"/>
    <dbReference type="EnsemblBacteria" id="ABB32355">
        <property type="protein sequence ID" value="ABB32355"/>
        <property type="gene ID" value="Gmet_2126"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2126"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024402_0_1_7"/>
    <dbReference type="OMA" id="CDFFMHE"/>
    <dbReference type="OrthoDB" id="1188552at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="52"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="520" mass="57160" checksum="95B638DA011BA5D7" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TW8</accession>
    <name>Q39TW8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bamK</name>
        <name evidence="2" type="ordered locus">Gmet_2077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32306.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514588.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2077"/>
    <dbReference type="EnsemblBacteria" id="ABB32306">
        <property type="protein sequence ID" value="ABB32306"/>
        <property type="gene ID" value="Gmet_2077"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2077"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127721_0_0_7"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017255">
        <property type="entry name" value="AcTrfase_GNAT_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037663">
        <property type="entry name" value="Acetyltransf_GNAT_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32306.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="146" mass="16639" checksum="8D560EA2C6A3A659" modified="2012-10-31" version="2">MKEQILIRNARPSDFDAIIALDETGHVEGKQAYWRRIFEHYVNCGDNDCHFLVSEINDKVVGFIVGEVRAWEFGSPPCGWVFALSVSPRNRKMGIGQRMFEEICACLKRSGAATVRTMVEREDKLTLSFFRNQGLSSGRYVELETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U42</accession>
    <name>Q39U42_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exopolysaccharide synthesis membrane protein H (Exosortase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">epsH</name>
        <name evidence="10" type="ordered locus">Gmet_2003</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512947.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2003"/>
    <dbReference type="EnsemblBacteria" id="ABB32232">
        <property type="protein sequence ID" value="ABB32232"/>
        <property type="gene ID" value="Gmet_2003"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2003"/>
    <dbReference type="eggNOG" id="COG1269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065975_0_0_7"/>
    <dbReference type="OMA" id="NENSIQW"/>
    <dbReference type="OrthoDB" id="1832262at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013426">
        <property type="entry name" value="EpsH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017540">
        <property type="entry name" value="Exosortase-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02602">
        <property type="entry name" value="8TM_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03109">
        <property type="entry name" value="exosortase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="285" mass="31278" checksum="B4E4A343145D11C9" modified="2005-11-22" version="1">MEIAAKNSLLPDRKGMILGLVCLGLFIYAYHDTFLWLVERYDNPDSHYSHGYLIPFICGYLVWMKRKDLAGLPRSSSRLGLGLIIAALLTHVASVWTHTFFTSGFSIMALAVGLCLYFYGPAITRQLAFPLGFLAFMFPLPMRVISAVSFPLKMMVANIGTAIMERSGMPIVREGAVIHLTNATLSVGDPCSGIRSLIALMAMGALFAYLLQAGIGKKLFLFSLSVPVAIATNVLRVCTLIFVADTLGGEWASPEHWFHTTSGLAVFFISMAVLFGIMRVLERPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U91</accession>
    <name>Q39U91_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">L-aspartate oxidase</fullName>
            <ecNumber evidence="4 10">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadB</name>
        <name evidence="13" type="ordered locus">Gmet_1954</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the oxidation of L-aspartate to iminoaspartate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4 10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511890.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1954"/>
    <dbReference type="EnsemblBacteria" id="ABB32183">
        <property type="protein sequence ID" value="ABB32183"/>
        <property type="gene ID" value="Gmet_1954"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1954"/>
    <dbReference type="eggNOG" id="COG0029">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_3_0_7"/>
    <dbReference type="OMA" id="DSPDIHY"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00551">
        <property type="entry name" value="nadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 10" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="6"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="436"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="531" mass="59682" checksum="3734E1AFCB4B3006" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U94</accession>
    <name>Q39U94_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1951</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32180">
        <property type="protein sequence ID" value="ABB32180"/>
        <property type="gene ID" value="Gmet_1951"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1951"/>
    <dbReference type="eggNOG" id="ENOG502ZVU3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_207127_0_0_7"/>
    <dbReference type="OMA" id="TGHICML"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="62" mass="6689" checksum="068A93F7104CA2D3" modified="2005-11-22" version="1">MAEQMTCSCGEKHQGHLCVLKSKGMMKEVSHLTSNPTVVCFICGSKANSGDNVCEPMALEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UJ0</accession>
    <name>Q39UJ0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Cell division protein FtsX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ftsX</name>
        <name evidence="12" type="ordered locus">Gmet_1855</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter FtsEX involved in cellular division.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Forms a membrane-associated complex with FtsE.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511991.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1855"/>
    <dbReference type="EnsemblBacteria" id="ABB32084">
        <property type="protein sequence ID" value="ABB32084"/>
        <property type="gene ID" value="Gmet_1855"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1855"/>
    <dbReference type="eggNOG" id="COG2177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073546_4_1_7"/>
    <dbReference type="OMA" id="ETGIMRL"/>
    <dbReference type="OrthoDB" id="1653234at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004513">
        <property type="entry name" value="ABC_transpt_FtsX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040690">
        <property type="entry name" value="FtsX_ECD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47755">
        <property type="entry name" value="PTHR47755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18075">
        <property type="entry name" value="FtsX_ECD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003097">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 12" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="238"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX_ECD" evidence="11">
        <location>
            <begin position="74"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR003097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="316" mass="34740" checksum="F4C0AAB72C0AB368" modified="2005-11-22" version="1">MSRNKPSIRPAMSSDGVGGRIRYFFARALLNIRQNVLVNVLAIGTITLALLIVSLFLLIFVNLESTADEWSGKIQVTAYFNTEPTPQELSAIMTRVKAIDGTDKVGYVSKQEAMKRFRERLKGQETLLEGVPADVLPSSIEITLKRNSREDAAMEAYVGRLKKVPGIAEVQYGEEWVRRFNTFMNFLRFVGALLGGFLLMAVLFIVSNTIKLTIYARKEEIEVMELVGATRFFIKAPFLIEGIIQGAAGAVLSLLILVAAFFGFLHSATNFVNFSSSVSGLSFLPPLYIAGILAGGVVLGFLGSLTSLKRFINNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UJ3</accession>
    <name>Q39UJ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA/RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365878.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1852"/>
    <dbReference type="DNASU" id="3741529"/>
    <dbReference type="EnsemblBacteria" id="ABB32081">
        <property type="protein sequence ID" value="ABB32081"/>
        <property type="gene ID" value="Gmet_1852"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1852"/>
    <dbReference type="eggNOG" id="COG3629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1281672_0_0_7"/>
    <dbReference type="OMA" id="HHICAER"/>
    <dbReference type="OrthoDB" id="1379556at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005158">
        <property type="entry name" value="BTAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03704">
        <property type="entry name" value="BTAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTAD" evidence="1">
        <location>
            <begin position="119"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="212" mass="23822" checksum="D951786E9AD03F43" modified="2005-11-22" version="1">MNPQPSGATVDKGSVNPEQISIKTFGGLGLSYLNSPMTILWESQKARILFCYLLISYDQWLHRDKLIDMLWPGCDPVSGAKNFKTTLSRLRKSFMGPRSINPIMTLGEAIRLDFNIFSLDSSQFKGYAQTGIKMLARGDISGARRYLEAAQDEYSGEFLPEEPFDHHICAERAELERLHESVLTSLQKVYQLEGNNDAVEAISFLKAVHTNS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UK4</accession>
    <name>PYRDB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName>Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit</fullName>
            <shortName>DHOD B</shortName>
            <shortName>DHODase B</shortName>
            <shortName>DHOdehase B</shortName>
            <ecNumber>1.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Dihydroorotate oxidase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>Orotate reductase (NADH)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">pyrD</name>
        <name type="ordered locus">Gmet_1841</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>(S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate</text>
            <dbReference type="Rhea" id="RHEA:13513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.3.1.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="pathway">
        <text>Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotetramer of 2 PyrK and 2 PyrD type B subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.14"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512005.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UK4"/>
    <dbReference type="SMR" id="Q39UK4"/>
    <dbReference type="STRING" id="269799.Gmet_1841"/>
    <dbReference type="EnsemblBacteria" id="ABB32070">
        <property type="protein sequence ID" value="ABB32070"/>
        <property type="gene ID" value="Gmet_1841"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1841"/>
    <dbReference type="eggNOG" id="COG0167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042042_0_0_7"/>
    <dbReference type="OMA" id="SCPHAKG"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004152">
        <property type="term" value="F:dihydroorotate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004589">
        <property type="term" value="F:orotate reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04740">
        <property type="entry name" value="DHOD_1B_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00224">
        <property type="entry name" value="DHO_dh_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033888">
        <property type="entry name" value="DHOD_1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024920">
        <property type="entry name" value="Dihydroorotate_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012135">
        <property type="entry name" value="Dihydroorotate_DH_1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001295">
        <property type="entry name" value="Dihydroorotate_DH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000164">
        <property type="entry name" value="DHO_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01037">
        <property type="entry name" value="pyrD_sub1_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00911">
        <property type="entry name" value="DHODEHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00912">
        <property type="entry name" value="DHODEHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000336444" description="Dihydroorotate dehydrogenase B (NAD(+)), catalytic subunit">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="47"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="71"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="194"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="245"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="267"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="305" mass="32214" checksum="846EF96B8106BC93" modified="2005-11-22" version="1">MKRPDLSVEIAGIKLRNPVMTASGTFGYGEEFAAYVNLEKIGAIITKGLSLKPKAGNPTPRIQETTGGMLNAIGLQNVGIDAFIEKKVPFLRTVNTPAIVNFFGNTVEEYAELAERLDKIPEVAGMEINISCPNVKHGGIVFGTEPKAAYSVVKAVREATIKPVIVKLSPNVTDIVEMAWACADAEADALSLINTLTGMAIDLKSRRPILANVTGGLSGPAVKPVALRMVWQVAKAVKIPVIGIGGIMSGTDALEFMLAGATAVQVGTANFLDPAASERIAAEMEQYLVNNGITDVKELIGALQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UQ2</accession>
    <name>Q39UQ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix DNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1791</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512055.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1791"/>
    <dbReference type="EnsemblBacteria" id="ABB32022">
        <property type="protein sequence ID" value="ABB32022"/>
        <property type="gene ID" value="Gmet_1791"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1791"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169577_0_0_7"/>
    <dbReference type="OMA" id="YPREIAS"/>
    <dbReference type="OrthoDB" id="1948163at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="109" mass="12627" checksum="89A105F223777EC5" modified="2005-11-22" version="1">MLEPLLSSTNCERVLIFIAARGEGYLREMADFYQTAPAPLLKQLEKLENGGVLFSRLAGRTRLYGFNPRYPFLNELRALLDKALTFYPEDIRVGLQENRRRPRRKGKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UQ7</accession>
    <name>Q39UQ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1786</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513317.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1786"/>
    <dbReference type="EnsemblBacteria" id="ABB32017">
        <property type="protein sequence ID" value="ABB32017"/>
        <property type="gene ID" value="Gmet_1786"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1786"/>
    <dbReference type="HOGENOM" id="CLU_2046317_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="120" mass="13844" checksum="24F6B08319F488D7" modified="2005-11-22" version="1">MIHDPAIGYQIQTLRLQGKQNDYEKVIDAVKKLPITSYSDISKARLSVKSDYGALIAAIAEALHKPFEWPEIRRLYDALARDFDGTEIDPDIKSPESFDKTIKTKMVEWQNKYQLSEKQK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UV7</accession>
    <name>SYE_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-tRNA synthetase</fullName>
            <shortName evidence="1">GluRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gltX</name>
        <name type="ordered locus">Gmet_1736</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513369.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UV7"/>
    <dbReference type="SMR" id="Q39UV7"/>
    <dbReference type="STRING" id="269799.Gmet_1736"/>
    <dbReference type="PRIDE" id="Q39UV7"/>
    <dbReference type="EnsemblBacteria" id="ABB31967">
        <property type="protein sequence ID" value="ABB31967"/>
        <property type="gene ID" value="Gmet_1736"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1736"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_6_3_7"/>
    <dbReference type="OMA" id="WDEGPFF"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045462">
        <property type="entry name" value="aa-tRNA-synth_I_cd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020751">
        <property type="entry name" value="aa-tRNA-synth_I_codon-bd_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008925">
        <property type="entry name" value="aa_tRNA-synth_I_cd-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020752">
        <property type="entry name" value="Glu-tRNA-synth_I_codon-bd_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19269">
        <property type="entry name" value="Anticodon_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48163">
        <property type="entry name" value="SSF48163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000237365" description="Glutamate--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="1">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="1">
        <location>
            <begin position="237"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00022"/>
        </source>
    </evidence>
    <sequence length="465" mass="51921" checksum="14AE3025BF8C9DBB" modified="2005-11-22" version="1">MSDVRLRFAPSPTGYLHVGGARTALFNWLLSRKEKGTFILRIEDTDVARSTQESVDAILQGMAWLGLGWDEGPFYQSERFPVYKEFVEKLVAEGKAYRCYCTSEALEAKRELAMKEGRKPKYDGTCRNGVEEPGDKPYVIRFKAPHEGVTVFDDLIKGRIAFNNDELDDLIIQRSDGTPTYNFVVVIDDATMGITTVIRGDDHINNTPRQILLYEALGYPVPRFAHVPMILGADKTRLSKRHGATSVMAYRDMGFLPEAMVNYLVRLGWSHGDQEIFSREELIEKFSIEAVGKSAGVFNPDKLLWLNHHYIKESASERLAELLIPFMKERGIVPESGPSLSLVVKTLQERSRTLVEMADGAIFYYRGDFAYDEQAAAKHLVPDAAPLLEALADKLEALADFSQASIEALFKEFIAEKGIKLGQVGPAVRVSLCGGTASPGIYEVIEALGKEETLRRLRRAVAFIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VI6</accession>
    <name>Q39VI6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1504</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511563.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1504"/>
    <dbReference type="EnsemblBacteria" id="ABB31738">
        <property type="protein sequence ID" value="ABB31738"/>
        <property type="gene ID" value="Gmet_1504"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1504"/>
    <dbReference type="eggNOG" id="COG0381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041674_0_1_7"/>
    <dbReference type="OMA" id="WFPYPEE"/>
    <dbReference type="OrthoDB" id="1117971at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="382" mass="42573" checksum="ECE4B4121A3FDA2F" modified="2005-11-22" version="1">MNVFLVAGARPNFMKIAPLYRESLTREGVTCRIVHTGQHYDYEMSQTFFDDLQLPQPDYFLNAGSGSHAEQTARVMVTFEELCAKELPDLVIVVGDVNSTLACSIVAKKAGIRVAHVEAGLRSFDLSMPEEINRMVTDSIADLYFVTETSAVRNLFNEGKPPEQIFLVGHVMVDNLLHQMVQVHLNGAVAPELRELKQKAGEYVFMTLHRPSNVDDEETFRGIAFAVNEIAARIPIIFPVHPRTRKMMESFGIQLHKGVTCLPPLSFSESLYFWKDARVVMTDSGGLQEETTALGVPCVTIRENTERPITVEMGTNVLAGTDPDRILTRVFDAAEGRGKRGKVPPFWDGKAAERIWDVIGRKYGKVPDLSEACHELMECVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VK9</accession>
    <name>Q39VK9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511587.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1481"/>
    <dbReference type="EnsemblBacteria" id="ABB31715">
        <property type="protein sequence ID" value="ABB31715"/>
        <property type="gene ID" value="Gmet_1481"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1481"/>
    <dbReference type="HOGENOM" id="CLU_1459337_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223542" evidence="2">
        <location>
            <begin position="22"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="185" mass="20881" checksum="D2BD0C84F8B8DC95" modified="2005-11-22" version="1">MTTRTGLVLVSLLLFTTIAEATPRIIELPDRIIVELYGTPGTPELPTPPPKAKEPYLVERFENHPDHYEVELVGKPEHDKDKPVDYTASASTYPQAVITQTATEQTYSSPSYGGDTPAMPVQSPYYRELSERIRILQRERQECLKTAPGEERADRDRKRREAEEKLREIRAVSAEMAQLRGQGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VM8</accession>
    <name>Q39VM8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511608.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1462"/>
    <dbReference type="EnsemblBacteria" id="ABB31696">
        <property type="protein sequence ID" value="ABB31696"/>
        <property type="gene ID" value="Gmet_1462"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1462"/>
    <dbReference type="eggNOG" id="COG3746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027640_0_0_7"/>
    <dbReference type="OMA" id="NTYMQLR"/>
    <dbReference type="OrthoDB" id="1015404at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032638">
        <property type="entry name" value="Porin_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16930">
        <property type="entry name" value="Porin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223429" evidence="1">
        <location>
            <begin position="26"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="655" mass="72335" checksum="22A5D3A5DFBA5402" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VS4</accession>
    <name>SYFB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheT</name>
        <name type="ordered locus">Gmet_1416</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511651.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VS4"/>
    <dbReference type="SMR" id="Q39VS4"/>
    <dbReference type="STRING" id="269799.Gmet_1416"/>
    <dbReference type="PRIDE" id="Q39VS4"/>
    <dbReference type="EnsemblBacteria" id="ABB31650">
        <property type="protein sequence ID" value="ABB31650"/>
        <property type="gene ID" value="Gmet_1416"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1416"/>
    <dbReference type="eggNOG" id="COG0072">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016891_0_0_7"/>
    <dbReference type="OMA" id="ISYNWLK"/>
    <dbReference type="OrthoDB" id="53568at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02796">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00283">
        <property type="entry name" value="Phe_tRNA_synth_beta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005121">
        <property type="entry name" value="Fdx_antiC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036690">
        <property type="entry name" value="Fdx_antiC-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004532">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033714">
        <property type="entry name" value="tRNA_bind_bactPheRS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PTHR10947"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03147">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00896">
        <property type="entry name" value="FDX-ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54991">
        <property type="entry name" value="SSF54991"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00472">
        <property type="entry name" value="pheT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51447">
        <property type="entry name" value="FDX_ACB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000232064" description="Phenylalanine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-binding" evidence="1">
        <location>
            <begin position="39"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="B5" evidence="1">
        <location>
            <begin position="401"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="FDX-ACB" evidence="1">
        <location>
            <begin position="708"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with alpha subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00283"/>
        </source>
    </evidence>
    <sequence length="801" mass="89219" checksum="69A043BC7F9EE4A0" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VX4</accession>
    <name>Q39VX4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PATAN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1366</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513142.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1366"/>
    <dbReference type="EnsemblBacteria" id="ABB31600">
        <property type="protein sequence ID" value="ABB31600"/>
        <property type="gene ID" value="Gmet_1366"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1366"/>
    <dbReference type="eggNOG" id="ENOG50322TS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076322_0_0_7"/>
    <dbReference type="OMA" id="FHDGSND"/>
    <dbReference type="OrthoDB" id="780212at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="316" mass="34838" checksum="08B885C72E03835F" modified="2005-11-22" version="1">MFLLPKGNPLYENIAAAKVKLPDMFEKLKAGGFTGYLNFTFPSATAILFFEAGKLISAVHEQDGRKLTGFEAIAGVCTLIFAGGGSLSVYRLSKDLTMCLHAMIHGDVLYAGQELKLIDIKGLLEKMKAQRLNGCLRLYTESRTALIFYKEGAPLGFFHDGSTDIETSATESQKIAGLPGAKIDVLSTKSADELMHYDLLEMVNVSKLWESTSSRFASERDKIRNEAAVVDRYQEEEKLRELEDDLKEVAMAYVGRMGAALVEKELNDRGGRRALQDSALVGAFLAGVEKGAKLLTSMSKTKEMLDTMKEEIARRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VY9</accession>
    <name>Q39VY9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnB</name>
        <name evidence="5" type="ordered locus">Gmet_1351</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the P(II) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513157.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1351"/>
    <dbReference type="EnsemblBacteria" id="ABB31585">
        <property type="protein sequence ID" value="ABB31585"/>
        <property type="gene ID" value="Gmet_1351"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1351"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_0_0_7"/>
    <dbReference type="OMA" id="PEWTEEV"/>
    <dbReference type="OrthoDB" id="2021322at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="112" mass="12380" checksum="8785CA068ABFE576" modified="2005-11-22" version="1">MKKVEAIIKPFKLDEVKEALNEIGIQGITVAEVKGFGRQKGHTELYRGAEYVVDFIPKIKMEIIVGDDIVGKVVETIEQAAKTGRIGDGKIFVTPVEEVIRIRTGERGEDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W38</accession>
    <name>Q39W38_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine desulfurase</fullName>
            <ecNumber evidence="4">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512066.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1300"/>
    <dbReference type="EnsemblBacteria" id="ABB31536">
        <property type="protein sequence ID" value="ABB31536"/>
        <property type="gene ID" value="Gmet_1300"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1300"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_4_7"/>
    <dbReference type="OMA" id="NNAATSW"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010969">
        <property type="entry name" value="Cys_dSase-rel_unknwn_funct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01977">
        <property type="entry name" value="am_tr_V_EF2568"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_5" evidence="6">
        <location>
            <begin position="4"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="381" mass="39889" checksum="3AC4DD3BAADB9BE9" modified="2005-11-22" version="1">MSLYLDNAATSYPKPEPVYEAVNRAMRDVGVSPGRGGYRRGIEASRLLFETRESVAALFGIGDSSRVVFTHSATEALNLAVLGLVRPGDHVVTTSAEHNSLVRPLHLAGQRGVEISWIEADRRGFVSPDQIAAAIRPSTRLIALAHCSNVTGAIQPVTEIAAVARRAGVLTLVDAAQSAGMIPLDVSAMGIDLLAAPGHKGLMGPPGTGILCVAEGVDLEPLFVGGTGGYSSGVEQPDAMPERFESGTHNLPGIAGLGAGVDFIRTVGLEVIRKREEELVAFLMDGLGALPGVTCHGPLPDEPRGGLVSFTVEGVDPQTIGFRLDQEFDICVRVGLHCAPAAHRTIGTYPGGAVRVSPGYFTTDEEIGTFLQAMGKIISSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W75</accession>
    <name>PSD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylserine decarboxylase proenzyme</fullName>
            <ecNumber evidence="1">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="1">Phosphatidylserine decarboxylase alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="1">Phosphatidylserine decarboxylase beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="1" type="primary">psd</name>
        <name type="ordered locus">Gmet_1263</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="1">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512104.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W75"/>
    <dbReference type="SMR" id="Q39W75"/>
    <dbReference type="STRING" id="269799.Gmet_1263"/>
    <dbReference type="DNASU" id="3739762"/>
    <dbReference type="EnsemblBacteria" id="ABB31499">
        <property type="protein sequence ID" value="ABB31499"/>
        <property type="gene ID" value="Gmet_1263"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1263"/>
    <dbReference type="eggNOG" id="COG0688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072492_0_0_7"/>
    <dbReference type="OMA" id="VSIFMSP"/>
    <dbReference type="OrthoDB" id="891720at2"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00664">
        <property type="entry name" value="PS_decarb_PSD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033175">
        <property type="entry name" value="PSD-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35809">
        <property type="entry name" value="PTHR35809"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00164">
        <property type="entry name" value="PS_decarb_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_0000262217" description="Phosphatidylserine decarboxylase beta chain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000262218" description="Phosphatidylserine decarboxylase alpha chain" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="1">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="1">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00664"/>
        </source>
    </evidence>
    <sequence length="218" mass="23917" checksum="32D0BF96CE2EF357" modified="2005-11-22" version="1">MRNSNTPIAAEGYPFIAGAVLIAVVLAVLGSKIPAFFFLAVFFGALTLFIVFFFRNPERTTPADENAVIAPADGVVIYLGPSREEHLGEEMTKISIFMSVFNVHVNRVPITGKVLDTFYIKGKFLDVRDDRATFENEQAGLIIETAKGMKMIVVQVAGLIARRIVCYAAKGDQLVRGKRYGLIRFGSRLDVYLPSETAVRVRMGDKTVAGETILGLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WA4</accession>
    <name>Q39WA4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptide ABC transporter, periplasmic peptide-binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1234</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365786.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1234"/>
    <dbReference type="EnsemblBacteria" id="ABB31470">
        <property type="protein sequence ID" value="ABB31470"/>
        <property type="gene ID" value="Gmet_1234"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1234"/>
    <dbReference type="eggNOG" id="COG0747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017028_8_6_7"/>
    <dbReference type="OMA" id="GEHEMAF"/>
    <dbReference type="OrthoDB" id="162819at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030678">
        <property type="entry name" value="Peptide/Ni-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039424">
        <property type="entry name" value="SBP_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023765">
        <property type="entry name" value="SBP_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000914">
        <property type="entry name" value="SBP_5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30290">
        <property type="entry name" value="PTHR30290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00496">
        <property type="entry name" value="SBP_bac_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002741">
        <property type="entry name" value="MppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01040">
        <property type="entry name" value="SBP_BACTERIAL_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223455" evidence="3">
        <location>
            <begin position="20"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="SBP_bac_5" evidence="4">
        <location>
            <begin position="81"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="538" mass="60295" checksum="8229F874763FF6E9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-06-10" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WK9</accession>
    <name>SFSA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sugar fermentation stimulation protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sfsA</name>
        <name type="ordered locus">Gmet_1127</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SfsA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513391.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39WK9"/>
    <dbReference type="SMR" id="Q39WK9"/>
    <dbReference type="STRING" id="269799.Gmet_1127"/>
    <dbReference type="DNASU" id="3741584"/>
    <dbReference type="EnsemblBacteria" id="ABB31365">
        <property type="protein sequence ID" value="ABB31365"/>
        <property type="gene ID" value="Gmet_1127"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1127"/>
    <dbReference type="eggNOG" id="COG1489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052299_2_0_7"/>
    <dbReference type="OMA" id="VTAHCPN"/>
    <dbReference type="OrthoDB" id="1375946at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00095">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005224">
        <property type="entry name" value="SfsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040452">
        <property type="entry name" value="SfsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041465">
        <property type="entry name" value="SfsA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30545">
        <property type="entry name" value="PTHR30545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03749">
        <property type="entry name" value="SfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17746">
        <property type="entry name" value="SfsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00230">
        <property type="entry name" value="sfsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000340141" description="Sugar fermentation stimulation protein homolog">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00095"/>
        </source>
    </evidence>
    <sequence length="232" mass="25832" checksum="725975969D24D2DD" modified="2005-11-22" version="1">MRLPTPLYPGTLVRRYQRFLADVQLADGTIVTAHCPNSGSMKGCNLPGSLVWLSKSTNPARKLAYTWELVMADGFWAGINTGLPNRLVREAIEDGTVTELQGYGSIRPEVRYGEERSRIDLLLEGEPGRCWVEVKNVTLVEGERALFPDAVTERGQKHLRELMEMVRRGDRGVIFYVVQRGDGEAVSPADAIDPKYGQLLRLAVANGVEALAYRALVTPEEIRLTERLPVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WN4</accession>
    <name>Q39WN4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513756.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1100"/>
    <dbReference type="EnsemblBacteria" id="ABB31340">
        <property type="protein sequence ID" value="ABB31340"/>
        <property type="gene ID" value="Gmet_1100"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1100"/>
    <dbReference type="HOGENOM" id="CLU_187647_0_0_7"/>
    <dbReference type="OrthoDB" id="2069184at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="77" mass="8982" checksum="D428E26EE81F9EA3" modified="2005-11-22" version="1">MASGRIEVIAYAGYRGEECPRAFVVGGVQVDVMKLLDLWTEENHFSKRRRRCFRVKGSDWRTYVICHDETGDEWSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WV2</accession>
    <name>Q39WV2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Znf/thioredoxin_put domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1032</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513205.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1032"/>
    <dbReference type="EnsemblBacteria" id="ABB31272">
        <property type="protein sequence ID" value="ABB31272"/>
        <property type="gene ID" value="Gmet_1032"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1032"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024180_0_0_7"/>
    <dbReference type="OMA" id="DQCNTKF"/>
    <dbReference type="OrthoDB" id="1249340at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021834">
        <property type="entry name" value="DUF3426"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011723">
        <property type="entry name" value="Znf/thioredoxin_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11906">
        <property type="entry name" value="DUF3426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13717">
        <property type="entry name" value="zinc_ribbon_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02098">
        <property type="entry name" value="MJ0042_CXXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Znf/thioredoxin_put" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="501" mass="52100" checksum="008DCB5942AD992E" modified="2005-11-22" version="1">MIIQCAQCKARFRLDDSKVSDAGIKVRCSKCKHIFVVKKEAPVEESDLDVLLQGLGSPSAGTELAAGAGTVAAVTAMPADQALEAATPPPAEEPFSFSGAPEEFSSSVVAESSEDREGYSLGIEPAEPEKPVADFQENTRPEEAFGGFEFEKDDSAAAAISGEAGFLASDSAMSEGGEELAGSGTIEEEEISFGEVSPEAFAAATGASASGVEGSEEEEISFEFEEADAAVYGENAEAEESAAGDVDFGEIDFGIEDAESESVSGGENLFSASAVSEPESAPMDKPAGEELPVTEIPPILPAAAAEGEAPPLSIASRRKGRSFLPSVVIAFSVLVIVALAGFGFYFFKEGPELLNRLGVGFLAEWFGVEGREEGVISLDKVGGTYLVNSEAGEVFVIRGEAVNNYRKSRAAIQVRGALLAAGGQAVVQKVAYCGNNLTDEQIKTLPFARIEAAMGNQFGDSLANLGVQAGKRIPFVIVIAKIPKDVVDYAVEVVGSTVASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WZ5</accession>
    <name>Q39WZ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sensor diguanylate cyclase/phosphodiesterase, PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0987</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31229.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514382.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0987"/>
    <dbReference type="EnsemblBacteria" id="ABB31229">
        <property type="protein sequence ID" value="ABB31229"/>
        <property type="gene ID" value="Gmet_0987"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0987"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_49_7"/>
    <dbReference type="OMA" id="NIDTHEL"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="235"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="308"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="391"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="533"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31229.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="793" mass="88976" checksum="824DD253C13CD81C" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XA3</accession>
    <name>Q39XA3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CHAD domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31121.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365737.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0879"/>
    <dbReference type="EnsemblBacteria" id="ABB31121">
        <property type="protein sequence ID" value="ABB31121"/>
        <property type="gene ID" value="Gmet_0879"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0879"/>
    <dbReference type="eggNOG" id="COG5607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_939292_0_0_7"/>
    <dbReference type="OMA" id="RIINAPS"/>
    <dbReference type="OrthoDB" id="1878295at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.40.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007899">
        <property type="entry name" value="CHAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038186">
        <property type="entry name" value="CHAD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05235">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00880">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51708">
        <property type="entry name" value="CHAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAD" evidence="1">
        <location>
            <begin position="6"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31121.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="296" mass="32745" checksum="E6007F093378E6B3" modified="2012-10-31" version="2">MTITDETPLWVAAPALLAARTDDFFGRWRRALKTLDSEDIHDLRVSSRRLREGCVLFSPLYPDGLARVIRRVRKVTRLLGPLRNADEAVFFFRELSVALPEPCRESLGVLMGRQEALRNVEHRRLAKGLESLGAGKTNSAFVRAMARPAVFPQPPVAVDPFTPIGSFAAAALDGSLADLLPLVPSARDEEAAAAQHALRIAVKHYRYRVEILSFLMAAEGYGDIHATIKAYQDCLGTMHDLDVFVDMVRHGGLPPEVECVILNAIAERRGKSFARFGELLGGHPFELIGEEVRRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XF3</accession>
    <name>Q39XF3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PATAN domain GTPase-activating protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365729.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0829"/>
    <dbReference type="EnsemblBacteria" id="ABB31071">
        <property type="protein sequence ID" value="ABB31071"/>
        <property type="gene ID" value="Gmet_0829"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0829"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141299_0_0_7"/>
    <dbReference type="OMA" id="EIIHAEQ"/>
    <dbReference type="OrthoDB" id="1331224at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="237" mass="25689" checksum="4700058D07E5B937" modified="2005-11-22" version="1">MMAESSRPEKQSGFEGSIAGLPLTDVIQLKGHNRFTGAISVEYRQRQGMIFFRDGEIIHAEQEGVVGEQALYEILRWPGGRFAVQPKVTTTGRSIQQSIAYLLLEAHRIIDEENAGLRPKGEGAGAAQRRMSVIAERLLQIAGVGYAVLFKKDGLPVDDEGAEAKALAEKGSELSRLGNRLGDLLGLGGVKSAAVQAKGEQQLLFEAKNHYISIAVNKETSLAQVESDIRATFGSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XG0</accession>
    <name>Q39XG0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pgsA-2</name>
        <name evidence="13" type="ordered locus">Gmet_0822</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365727.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0822"/>
    <dbReference type="EnsemblBacteria" id="ABB31064">
        <property type="protein sequence ID" value="ABB31064"/>
        <property type="gene ID" value="Gmet_0822"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0822"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_6_2_7"/>
    <dbReference type="OMA" id="KRFNMAS"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00560"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="198" mass="21014" checksum="FB3CA91134F2C9F1" modified="2005-11-22" version="1">MGTVSVNESEGRGAATVNGIVTIPNALTALRIVLVPALITFLLDGNFRAALTVFLVAGVSDALDGFIARRFNQQSRLGSFLDPLADKLLVVTSSLVLAAIGRLPWWLALVIVGRDLVIVAGAIAYYGRTGTLEMDPSIASKANTFVQISLILTVLAHGAGMEFLGVVLKPLFVLALAMTLVSGGDYMVVWGRRAFRKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XQ2</accession>
    <name>Q39XQ2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sucD-1</name>
        <name evidence="2" type="synonym">sucD</name>
        <name evidence="7" type="ordered locus">Gmet_0730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514447.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0730"/>
    <dbReference type="EnsemblBacteria" id="ABB30972">
        <property type="protein sequence ID" value="ABB30972"/>
        <property type="gene ID" value="Gmet_0730"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0730"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_7"/>
    <dbReference type="OMA" id="GEGMKHT"/>
    <dbReference type="OrthoDB" id="1081709at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="17"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="96"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="291" mass="30216" checksum="DBD607D389953E1E" modified="2005-11-22" version="1">MSILINKDSKIVVQGITGRSGLFHTQQCRDYGSRIVAGVTPGKGGIHIEGIPVFNTVEEAVRYTGANVSMIFVPPPGAADAILEAADAGVDLAVCITEGIPVRDMVPVKRILQGSKTRLVGPNCPGVITPGECKVGIMPGYIHKPGKIGVVSRSGTLTYEAVKQITEAGLGQSTCVGIGGDPIIGMQFIDVLKLFNEDKQTEAVFMIGEIGGSAEEDAAEWIRENMKKPVAAFIAGVTAPPGKRMGHAGAIITGGKGKAEDKIRTLGECGVVVAPSPTKMGAAMLEALGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XS9</accession>
    <name>Q39XS9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514094.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0703"/>
    <dbReference type="EnsemblBacteria" id="ABB30945">
        <property type="protein sequence ID" value="ABB30945"/>
        <property type="gene ID" value="Gmet_0703"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0703"/>
    <dbReference type="HOGENOM" id="CLU_2879459_0_0_7"/>
    <dbReference type="OMA" id="DDFCDVG"/>
    <dbReference type="OrthoDB" id="1920686at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="63" mass="7300" checksum="86C531B4CF957607" modified="2005-11-22" version="1">MKDGIVCPFYGKSDDICDVGCGYISPHDVNMIIKFCSCRYRECMKYQELSERFPHEVLTPVKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XW8</accession>
    <name>Q39XW8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Nitrogenase molybdenum-iron protein beta chain</fullName>
            <ecNumber evidence="5 9">1.18.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Dinitrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">nifK</name>
        <name evidence="11" type="ordered locus">Gmet_0664</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate</text>
            <dbReference type="Rhea" id="RHEA:21448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17997"/>
            <dbReference type="ChEBI" id="CHEBI:18276"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.18.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[8Fe-7S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21143"/>
        </cofactor>
        <text evidence="9">Binds 1 [8Fe-7S] cluster per heterodimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NifD/NifK/NifE/NifN family.</text>
    </comment>
    <dbReference type="EC" id="1.18.6.1" evidence="5 9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514272.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0664"/>
    <dbReference type="EnsemblBacteria" id="ABB30906">
        <property type="protein sequence ID" value="ABB30906"/>
        <property type="gene ID" value="Gmet_0664"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0664"/>
    <dbReference type="eggNOG" id="COG2710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025876_2_0_7"/>
    <dbReference type="OMA" id="GLNNMID"/>
    <dbReference type="OrthoDB" id="397330at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016612">
        <property type="term" value="C:molybdenum-iron nitrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018697">
        <property type="term" value="F:carbonyl sulfide nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016163">
        <property type="term" value="F:nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000510">
        <property type="entry name" value="Nase/OxRdtase_comp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000318">
        <property type="entry name" value="Nase_comp1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005976">
        <property type="entry name" value="Nase_Mo-Fe_CF_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00148">
        <property type="entry name" value="Oxidored_nitro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01286">
        <property type="entry name" value="nifK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00699">
        <property type="entry name" value="NITROGENASE_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_nitro" evidence="10">
        <location>
            <begin position="50"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="489" mass="53886" checksum="983156D985515BA5" modified="2005-11-22" version="1">MANNLGLAVKPVTETPVEEIERVAAWINTEEYRDLNFKREALVVAPPHACQPLGAELAAHAFEGSLPFVHGSQGCASYYRSTLNRHFREPAPAVSDSMTEDGAVFGGQNNLHEGLENAIALYKPKMVSIFTSCMPEIIGDDLSAFIKNARNKGIVPADMPVPYANTPSFSGSHVHGYDAMLLSILQALTEGKKVEGRCTGKINLLPGFDANTGNFREYKRIFEAFGVPYTILGDISDVFDSPLDGTYRIYPGGTRLDDAADSINGKATISLGPYSATKTYAWAKDNYAGKHTALPMPLGIAKTDAFLMKIAEVAGKPVPESFKAERGRAVDAMTDAHQYMHGKKFALYGDPDQLIGYVSFLLEMGAVPYHILCSKGSKKVEKEIQALLDLSPYGKQGKIYMGKDLWHMRSLIMTDPVDAIIGDTHGKFMARDAKIPLFRFGFPVLDRVNLHRYPIIGYQGVINMVTTICNKFIDITDETCEDRQFEMMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XX2</accession>
    <name>Q39XX2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrogen fixation transcript antitermination response regulator, ANTAR domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gnfR</name>
        <name evidence="4" type="ordered locus">Gmet_0660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30902.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365707.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0660"/>
    <dbReference type="EnsemblBacteria" id="ABB30902">
        <property type="protein sequence ID" value="ABB30902"/>
        <property type="gene ID" value="Gmet_0660"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0660"/>
    <dbReference type="eggNOG" id="COG3707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_65_0_7"/>
    <dbReference type="OMA" id="QKTSMDR"/>
    <dbReference type="OrthoDB" id="1958442at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005561">
        <property type="entry name" value="ANTAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008327">
        <property type="entry name" value="Sig_transdc_resp-reg_antiterm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03861">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036382">
        <property type="entry name" value="RR_antiterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01012">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50921">
        <property type="entry name" value="ANTAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="ANTAR" evidence="3">
        <location>
            <begin position="123"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30902.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="187" mass="21026" checksum="048A6F8E4896F9B7" modified="2012-10-31" version="2">MRSVLVCDDEPIIRMSLKNKLKELGFDEIRECGDGEQAVATALATMPDIIILDVSMPKKDGITAAREIRQRLKIPIILLTACCDPDTVRRAKESGIGGFLAKPLREQDLWPAIELACAHADEVETLKEEVEDLKEILESRKVIEKAKGVLMRNQGLSEPEAFRRMQKLAMDKRKSMRQIAEAILLTE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XY1</accession>
    <name>RS11_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsK</name>
        <name type="ordered locus">Gmet_0651</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365705.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XY1"/>
    <dbReference type="SMR" id="Q39XY1"/>
    <dbReference type="STRING" id="269799.Gmet_0651"/>
    <dbReference type="EnsemblBacteria" id="ABB30893">
        <property type="protein sequence ID" value="ABB30893"/>
        <property type="gene ID" value="Gmet_0651"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0651"/>
    <dbReference type="eggNOG" id="COG0100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072439_5_0_7"/>
    <dbReference type="OMA" id="KWGVAHI"/>
    <dbReference type="OrthoDB" id="1713391at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019981">
        <property type="entry name" value="Ribosomal_S11_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_S11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_S11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="PTHR11759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03632">
        <property type="entry name" value="uS11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000230403" description="30S ribosomal protein S11">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01310"/>
        </source>
    </evidence>
    <sequence length="131" mass="14015" checksum="C8D8D9BBB7A075A8" modified="2005-11-22" version="1">MASPAKKVVKKKKEKKNIPNGVAHIQATFNNTIITITDPAGNVVAWSSAGGKGFKGSRKSTPFAAQVAAEDCAKKAQDHGMRSVEVYVKGPGSGRESALRALQAAGFHVNFIRDVTPIPHNGCRPPKRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y38</accession>
    <name>Q39Y38_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512291.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0593"/>
    <dbReference type="EnsemblBacteria" id="ABB30836">
        <property type="protein sequence ID" value="ABB30836"/>
        <property type="gene ID" value="Gmet_0593"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0593"/>
    <dbReference type="eggNOG" id="ENOG502ZG50">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1560746_0_0_7"/>
    <dbReference type="OrthoDB" id="2150074at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223510" evidence="2">
        <location>
            <begin position="20"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="172" mass="18916" checksum="56306B048367F37A" modified="2005-11-22" version="1">MIKKSIALLLLAVATASCSSVDTREAEQVRETVKRYNTQLAQGYATMNMGGLARVAEEPQTAKVYFHMAALGEGRIRMMSELKDISFKDIRFAAATSASVKTREVWDFRHVNIDTGKVERDEKGFVYRTNYHLAKKNGAWWVRDVAAEGEKGKGADTKASPAAPASGKASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y60</accession>
    <name>Q39Y60_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512268.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0571"/>
    <dbReference type="EnsemblBacteria" id="ABB30814">
        <property type="protein sequence ID" value="ABB30814"/>
        <property type="gene ID" value="Gmet_0571"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0571"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3880">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_235482_0_0_7"/>
    <dbReference type="OMA" id="AVDCTEN"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010176">
        <property type="entry name" value="C4xCH_C2xCH_motif_GEOSU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09698">
        <property type="entry name" value="GSu_C4xC__C2xCH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01904">
        <property type="entry name" value="GSu_C4xC__C2xCH"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223452" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1848" mass="192200" checksum="BC0043F38CCC8B19" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YB5</accession>
    <name>Q39YB5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thiol:disulfide interchange protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">dsbD</name>
        <name evidence="3" type="ordered locus">Gmet_0516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512212.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0516"/>
    <dbReference type="EnsemblBacteria" id="ABB30759">
        <property type="protein sequence ID" value="ABB30759"/>
        <property type="gene ID" value="Gmet_0516"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0516"/>
    <dbReference type="eggNOG" id="COG4232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053225_0_2_7"/>
    <dbReference type="OMA" id="LGCFLWG"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="22"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="228" mass="23705" checksum="2874BB04D1DD7A47" modified="2005-11-22" version="1">MSLLDNIEQIVATQPLLAFGAVFMGGVLSSASPCVLATIPLVVGFVGGHAGESRKKAFLYSLSFIIGLSLTFTIFGAAAALLGTMFGTVGGWWYVAVGAVAVAMGLQMLGLYDLNLPALPQFRPKRGGLVGALLLGLFFGVASSPCATPVLVVILSFAALKGNILDGTFLLFTYALGHCLLMLAAGTFTGFVEAFAASRGVADISLWGKRVSGFIIALAGAWFIWRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YI6</accession>
    <name>Q39YI6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Flagellar secretion chaperone FliS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fliS</name>
        <name evidence="7" type="ordered locus">Gmet_0445</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the FliS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513813.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0445"/>
    <dbReference type="EnsemblBacteria" id="ABB30688">
        <property type="protein sequence ID" value="ABB30688"/>
        <property type="gene ID" value="Gmet_0445"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0445"/>
    <dbReference type="eggNOG" id="COG1516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080373_4_2_7"/>
    <dbReference type="OMA" id="AKRHMEA"/>
    <dbReference type="OrthoDB" id="1730695at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16098">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003713">
        <property type="entry name" value="FliS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036584">
        <property type="entry name" value="FliS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34773">
        <property type="entry name" value="PTHR34773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02561">
        <property type="entry name" value="FliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039090">
        <property type="entry name" value="Flis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101116">
        <property type="entry name" value="SSF101116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00208">
        <property type="entry name" value="fliS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="140" mass="15936" checksum="965F006CCBB550B5" modified="2005-11-22" version="1">MYSPLNQYQNNQVLTASPEKILIMLYDGAINFTRIAQERLLVKDVPGKGIYIGKALAIVTELMNTLNHEVGGEIAAHLEQLYLYLMDEYTKANMSYEMAHLENAVKILTILRDTWKEAAEIVQRERVALLNEQHVSRMAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YL9</accession>
    <name>MURG_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.227</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murG</name>
        <name type="ordered locus">Gmet_0412</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans-octa-cis-undecaprenyl diphospho-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-glucosamine = di-trans-octa-cis-undecaprenyl diphospho-[N-acetyl-alpha-D-glucosaminyl-(1-&gt;4)]-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:31227"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:61387"/>
            <dbReference type="ChEBI" id="CHEBI:61388"/>
            <dbReference type="EC" id="2.4.1.227"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 28 family. MurG subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.227" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512384.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YL9"/>
    <dbReference type="SMR" id="Q39YL9"/>
    <dbReference type="STRING" id="269799.Gmet_0412"/>
    <dbReference type="CAZy" id="GT28">
        <property type="family name" value="Glycosyltransferase Family 28"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30655">
        <property type="protein sequence ID" value="ABB30655"/>
        <property type="gene ID" value="Gmet_0412"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0412"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037404_2_0_7"/>
    <dbReference type="OMA" id="AADMMLC"/>
    <dbReference type="OrthoDB" id="1165736at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051991">
        <property type="term" value="F:UDP-N-acetyl-D-glucosamine:N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine-diphosphoundecaprenol 4-beta-N-acetylglucosaminlytransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050511">
        <property type="term" value="F:undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030259">
        <property type="term" value="P:lipid glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00033">
        <property type="entry name" value="MurG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006009">
        <property type="entry name" value="GlcNAc_MurG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01133">
        <property type="entry name" value="murG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000002651" description="UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase">
        <location>
            <begin position="1"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00033"/>
        </source>
    </evidence>
    <sequence length="364" mass="39781" checksum="824FEE1045B68C46" modified="2005-11-22" version="1">MRLLIAGGGTGGHLFPGIAVAEEFLSRKKGNEVLFVGTWRGIEARVLPKLGYRLECITAAGIRGKGSVARAKGLAKFLYGYAQSRKILKEFKPDLVLGVGGYASAPALLAARGMHIPRFIHEQNAIPGFTNKMLATVAERVFISLEESRKFFPEERTLLTGNPLRRQILEQVALAPQEERTDDAFHLLVFGGSAGAHRINLIMGEVLPHLEDVKERLRITHQTGENDLEDVTSAYEEQGVAADVVAFIDSMADAYRWADLVVCRAGATTIAEITACGKPCIFIPYPHAVDDHQRRNAEALLKRGAGFVIIEQELSGEVLAKTIRDLMADPARLKSVGEAAQGLARLDAAQVIVDEMMTSKRKEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YP7</accession>
    <name>HISX_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidinol dehydrogenase</fullName>
            <shortName evidence="1">HDH</shortName>
            <ecNumber evidence="1">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisD</name>
        <name type="ordered locus">Gmet_0384</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-histidinol + 2 NAD(+) = 3 H(+) + L-histidine + 2 NADH</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512356.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YP7"/>
    <dbReference type="SMR" id="Q39YP7"/>
    <dbReference type="STRING" id="269799.Gmet_0384"/>
    <dbReference type="EnsemblBacteria" id="ABB30627">
        <property type="protein sequence ID" value="ABB30627"/>
        <property type="gene ID" value="Gmet_0384"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0384"/>
    <dbReference type="eggNOG" id="COG0141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006732_3_3_7"/>
    <dbReference type="OMA" id="MVTGPGN"/>
    <dbReference type="OrthoDB" id="935289at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01024">
        <property type="entry name" value="HisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="PTHR21256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000229857" description="Histidinol dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="361"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01024"/>
        </source>
    </evidence>
    <sequence length="436" mass="46819" checksum="8351D95E512B3904" modified="2005-11-22" version="1">MKFLDIRDTNFDMEFAAILARGEETGREVEQVVLDIIADVRARGDEALLEYTRRFDRLEADSVASLQVTEDEVDYAFARVKDEEIAALKLAVERVARFHEKQKQETWLSTGEPDILLGQMVTPLERVGIYVPGGKASYPSSVIMNAVPARVAGVGEVVMVAPTPGGEINPHVLVAARFSGVDRIFRLGGAQAVAALAYGTATVPKVDKITGPGNIYVATAKKLVFGQVGIDMIAGPSEILVINDGSGTPAHIAADLLSQAEHDELASSILITTDRGFGERVAAEVERQLAELSRETIARRSWETYGAVIVAGSLDEAIAFSNRIAPEHLELAVTNPFDVLPKIRNAGAIFLGHFTPEAAGDYLAGPNHTLPTGGTARFFSPLSVDDFVKKSSIVYFSESGLNRLGGGIVRIAELEGLEAHGRSVSVRLKGEGEARK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YP8</accession>
    <name>HIS1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="1">ATP-PRT</shortName>
            <shortName evidence="1">ATP-PRTase</shortName>
            <ecNumber evidence="1">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisG</name>
        <name type="ordered locus">Gmet_0383</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text>Lacks the C-terminal regulatory region which is replaced by HisZ.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP phosphoribosyltransferase family. Short subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512355.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YP8"/>
    <dbReference type="SMR" id="Q39YP8"/>
    <dbReference type="STRING" id="269799.Gmet_0383"/>
    <dbReference type="EnsemblBacteria" id="ABB30626">
        <property type="protein sequence ID" value="ABB30626"/>
        <property type="gene ID" value="Gmet_0383"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0383"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_2_0_7"/>
    <dbReference type="OMA" id="YVMMDYD"/>
    <dbReference type="OrthoDB" id="1419568at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13595">
        <property type="entry name" value="PBP2_HisGs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01018">
        <property type="entry name" value="HisG_Short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024893">
        <property type="entry name" value="ATP_PRibTrfase_HisG_short"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000229316" description="ATP phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01018"/>
        </source>
    </evidence>
    <sequence length="212" mass="23963" checksum="079AF683CCBF59A1" modified="2005-11-22" version="1">MSDFLTIAIPKGRILEESVALFGKIGIHCDELLSNTRKLIFENREQRMRYMIVRATDVPTYVEYGCADLGIVGKDTLMEQEKDLYEPLDLKFGYCRMMVAEPAGLARDDDPSSWSNIRIATKYPNVTEKYFAKKGVQVEIIKLYGSIELAPLVGLSERIVDLVSTGETLRQNGLVEVETIAEITTRLIVNRASLKTKHPRITEIIEGLEKHV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YQ4</accession>
    <name>RL31_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmE</name>
        <name type="ordered locus">Gmet_0377</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the 23S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512349.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YQ4"/>
    <dbReference type="SMR" id="Q39YQ4"/>
    <dbReference type="STRING" id="269799.Gmet_0377"/>
    <dbReference type="EnsemblBacteria" id="ABB30620">
        <property type="protein sequence ID" value="ABB30620"/>
        <property type="gene ID" value="Gmet_0377"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0377"/>
    <dbReference type="eggNOG" id="COG0254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114306_4_3_7"/>
    <dbReference type="OMA" id="WYPDAKV"/>
    <dbReference type="OrthoDB" id="2014569at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00501">
        <property type="entry name" value="Ribosomal_L31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002150">
        <property type="entry name" value="Ribosomal_L31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027491">
        <property type="entry name" value="Ribosomal_L31_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042105">
        <property type="entry name" value="Ribosomal_L31_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33280">
        <property type="entry name" value="PTHR33280"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01197">
        <property type="entry name" value="Ribosomal_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01249">
        <property type="entry name" value="RIBOSOMALL31"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00105">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01143">
        <property type="entry name" value="RIBOSOMAL_L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000259189" description="50S ribosomal protein L31">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00501"/>
        </source>
    </evidence>
    <sequence length="66" mass="7532" checksum="71920581EE023624" modified="2005-11-22" version="1">MKEGIHPKYNEVTVKCACGNSFQTRSTRTEISTEICSACHPFFTGKQKLVDTAGRVERFRKKYGMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YU8</accession>
    <name>Q39YU8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Proton/nitrate symporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">narK</name>
        <name evidence="9" type="ordered locus">Gmet_0333</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365655.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0333"/>
    <dbReference type="EnsemblBacteria" id="ABB30576">
        <property type="protein sequence ID" value="ABB30576"/>
        <property type="gene ID" value="Gmet_0333"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0333"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_14_0_7"/>
    <dbReference type="OMA" id="YCQYYSV"/>
    <dbReference type="OrthoDB" id="1217595at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015112">
        <property type="term" value="F:nitrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044772">
        <property type="entry name" value="NO3_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23515">
        <property type="entry name" value="PTHR23515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="32"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="439" mass="48166" checksum="2B171F57B66F7C95" modified="2005-11-22" version="1">MERHEQKTATAATWGTQVRTRTMATHRYKQISVLTMNTFAFTVCFAVWVMFSIIGIPIKGALGLNETQFGILAATPILSGSLIRLPLGMWTDKYGGRIVFFILMLCTIVPIYLVSAATAYWHFLLLGLFIGLAGGAFSVGISYTARWFTKARQGFAMGIFGAGNAGAAVTKFLAPSLVVAYGWQMVPKVYAVAMLVTAILFWAFTFTEHSHKVSSTVTIKDQLAALRDPKVWRYCQYYAIVFGGYVGLSLWMTKYYINEYGFDIRTAALVAAIFVLPSGVIRALGGWLSDRFGAHTVTCWVMWVSGGCLLLLSIPHFDVVVTTVNGPVARHVGLNVWVFTSLLFVVGIAWGFGKASVFKHISDEYPHNIGVISGIVGLIGGLGGFVLPIMFGALVDLTGVRSTAFMLLYGSTCVSLFWMYLALKKENVHRKLKTADILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YX0</accession>
    <name>Q39YX0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Succinate dehydrogenase/fumarate reductase, type E, iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sdhB</name>
        <name evidence="4" type="ordered locus">Gmet_0309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514021.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0309"/>
    <dbReference type="EnsemblBacteria" id="ABB30554">
        <property type="protein sequence ID" value="ABB30554"/>
        <property type="gene ID" value="Gmet_0309"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0309"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_1_7"/>
    <dbReference type="OMA" id="HCQQCTT"/>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="344" mass="38950" checksum="1E3E16B7A2CA7B73" modified="2005-11-22" version="1">MERREVSFRIYRYNPQVDRTPFYDNFRIAVEKGITILRALNHIKEHLEPRLTFRAFCQAGICGSCAVRINGVSKLACTTQVWDELGGDGEHTILIEPLNNLEVIRDLVVDIDPIMDKLKENYSWVKPAIPQEEMGRKEHLVSDGEFEAINAASDCILCGSCYSECSMMEVNRSYISPPVLVKAFRMNNDSRDTLACERLERVSSDHGLWDCAHCHKCMEHCTKNIPIMDGIHRLREEAFERGMTDSEGARHAQAFFDDIRDLGRLREVTLPLRTKGMIGSLRMVPLAVKMGLKGRTPPLWVRPIPDIDRVSDIYSRLEANPGGEAVGAIHELPLRSAPRSGECL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YZ5</accession>
    <name>Q39YZ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0284</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0284"/>
    <dbReference type="EnsemblBacteria" id="ABB30529">
        <property type="protein sequence ID" value="ABB30529"/>
        <property type="gene ID" value="Gmet_0284"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0284"/>
    <dbReference type="eggNOG" id="COG4319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899435_0_0_7"/>
    <dbReference type="OrthoDB" id="2048050at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="309" mass="35238" checksum="EE7AF036DA3F9C20" modified="2005-11-22" version="1">MSNSRNTRYSGGHMRFIGNLITVISVLFLATTSFGADISESDVKIFLNDWLAAQNKGSYPDYAALYSESFVGIKRSGKSMRKFDHDSWLKDRKTMFKKKMLVAANSPEITISGTTALVKFEQTWESGTYKDKGYKVLDLSLEDEKLKIVREEMLFSIVDTKFSSAFTRFNKDCKNKFSDIEEGQDMPIICNGPYKYKIEINYSACCEYVQVSDNKNFVLDLPAQIISTVTNRVLEWRLANGKPFAVILKLDKYKGDLALDAKKVKEVLLIKGLKKFEDINYEVDIKGQSNPNLEARSLADQSYMRLLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YZ8</accession>
    <name>Q39YZ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513598.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30526">
        <property type="protein sequence ID" value="ABB30526"/>
        <property type="gene ID" value="Gmet_0281"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0281"/>
    <dbReference type="eggNOG" id="ENOG502ZSRH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072562_0_0_7"/>
    <dbReference type="OMA" id="IWNSATV"/>
    <dbReference type="OrthoDB" id="1729395at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="262" mass="28943" checksum="9186AA5EEF3D3D91" modified="2005-11-22" version="1">MPVAQYAIGPPTRPKNIRHDNGFLDSFARRKPTAKDYEEYARWISRLEGVEAIQGVPFVPHNNLPDALAAYRHFLRGNGKDHLFSYERFVSSDPSGAVILSSAVLDARQGAELLYGEYFKGQSPVLFQMSGSAIPVGSIRYPSFPYPKTENWQKAIGAHVIWLSADVDVEIANGVHSFVMQMTLHAEDRYNFNPGAADIASGIPDSANGIFEVTGLAHQYMNTSTINRRVEWVGLGSPQGISPKRRSTDFTREKACGQSAHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z68</accession>
    <name>Q39Z68_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512799.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0210"/>
    <dbReference type="EnsemblBacteria" id="ABB30456">
        <property type="protein sequence ID" value="ABB30456"/>
        <property type="gene ID" value="Gmet_0210"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0210"/>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1084867_0_0_7"/>
    <dbReference type="OMA" id="ECATAYG"/>
    <dbReference type="OrthoDB" id="1776107at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="150"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="250" mass="27493" checksum="EE6E7774542373F9" modified="2005-11-22" version="1">MIARYLVIVGLLLLAACGKKGPLVPPESFAPAPVSALSVEQKEDAFYVSWPAPSKDEAGRPLKELAGFRVFRRPVLPPDQDCEECPTAYTVVKTVDLEYPQDVRFYNNRYVFADRNLTDGVTYQYKVVSFRRDGSESAASNRARRAKVTAPPAPHLSAAAGPTSVVLQWEPPSGTVGKPVGAYVYRCRGEAVSTLVLLTPTPVVERQYEDLRLERGVTYVYTVREVVDIDGMPVESAVSNEVRGMLAEPE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z84</accession>
    <name>Y194_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative nickel insertion protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_0194</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LarC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512783.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z84"/>
    <dbReference type="SMR" id="Q39Z84"/>
    <dbReference type="STRING" id="269799.Gmet_0194"/>
    <dbReference type="EnsemblBacteria" id="ABB30440">
        <property type="protein sequence ID" value="ABB30440"/>
        <property type="gene ID" value="Gmet_0194"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0194"/>
    <dbReference type="eggNOG" id="COG1641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028523_2_1_7"/>
    <dbReference type="OMA" id="TCLGLDW"/>
    <dbReference type="OrthoDB" id="1547060at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01074">
        <property type="entry name" value="LarC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002822">
        <property type="entry name" value="Ni_insertion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36566">
        <property type="entry name" value="PTHR36566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01969">
        <property type="entry name" value="DUF111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00299">
        <property type="entry name" value="TIGR00299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000064649" description="Putative nickel insertion protein">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01074"/>
        </source>
    </evidence>
    <sequence length="390" mass="41884" checksum="AB512DF2A3F1BF4E" modified="2005-11-22" version="1">MKILYCDCFAGIAGDMTVAALLDLGVPFEVVEGAVKQLPLPHSSYSLAVERTSRKGIAAARFVVHVEEHQPHRHYADIAAMIEESTLAEGVKEKAQRIFFRLAEAEAKVHGVEIGRVHFHEVGAVDSIVDIVGTAAALEWLGIDAVHAAPLPLGSGFVETAHGRLPVPAPATAELLRGLPIHGEAGSGERVTPTGAAILAALATGFGRAPAMTVTGVGCGAGTKDFDDIPNVMRLFMGEAEGGLLRDEVCIIETHIDDMNPEILGHVLERLMEAGALDAAFSPLQMKKNRPAVKLTVIARPGQRDELAALVLRETSAIGVRFYPASRLKLSREKEERPTSLGPVTVKVIRDGGRVVRVTPEYDACRRIAAEREMSLLEVYRIVEREAGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z94</accession>
    <name>Q39Z94_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphoaspartate phosphatase CheX associated with MCPs of class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheX40H</name>
        <name evidence="3" type="ordered locus">Gmet_0184</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512773.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0184"/>
    <dbReference type="EnsemblBacteria" id="ABB30430">
        <property type="protein sequence ID" value="ABB30430"/>
        <property type="gene ID" value="Gmet_0184"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0184"/>
    <dbReference type="eggNOG" id="COG1406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116290_0_1_7"/>
    <dbReference type="OrthoDB" id="1956590at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038756">
        <property type="entry name" value="CheX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39452">
        <property type="entry name" value="PTHR39452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="55"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="169" mass="17859" checksum="C96D5B3C4829D23E" modified="2005-11-22" version="1">MPLSFTVGGATLAEEDLATHIVGAVKNIFATMIFISDIEDRYPLDKPVSHFTCSISGMVGLGGDCTGMVGIHIPEELAREATASMLGMEMDEIEGDGDVHDAMGELTNMLAGEVKMIFSARGMSVCLSTPSVISGREYSVEVVSSGAAVVVPFDRGEHRFLATLQLEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZC9</accession>
    <name>Q39ZC9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512731.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0146"/>
    <dbReference type="EnsemblBacteria" id="ABB30395">
        <property type="protein sequence ID" value="ABB30395"/>
        <property type="gene ID" value="Gmet_0146"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0146"/>
    <dbReference type="eggNOG" id="COG3530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176025_0_0_7"/>
    <dbReference type="OMA" id="MPFGKYE"/>
    <dbReference type="OrthoDB" id="1886238at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024530">
        <property type="entry name" value="QSregVF_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40613">
        <property type="entry name" value="PTHR40613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12843">
        <property type="entry name" value="QSregVF_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="74" mass="8724" checksum="A612AFECC0472140" modified="2005-11-22" version="1">MEQYPSNDHEQLLELATMRMPFGKYQGRRLIDLPEPYVVWFAGQGFPEGKLGTMLRAVYEIKVNGLEYLFDRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZD7</accession>
    <name>Q39ZD7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512723.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0138"/>
    <dbReference type="DNASU" id="3739619"/>
    <dbReference type="EnsemblBacteria" id="ABB30387">
        <property type="protein sequence ID" value="ABB30387"/>
        <property type="gene ID" value="Gmet_0138"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0138"/>
    <dbReference type="eggNOG" id="COG5316">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039933_0_0_7"/>
    <dbReference type="OMA" id="VLEQNYE"/>
    <dbReference type="OrthoDB" id="541612at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223468" evidence="1">
        <location>
            <begin position="23"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="469" mass="52468" checksum="692F1DF75948A652" modified="2005-11-22" version="1">MRQRFLPLLALLSLLLPLPAPAAPTVSTVADQTGIALTIYNRNLGLVKDRREIRLAPGNGELRFMDVAAQIIPTSVSIASLAGGELQVLEQNYEYDLLSPQKLMDKYVGKEVKLHQKNPYTEREEVVTATLLSNNGGPVYRIGDEITFGHPGRLIFPGVPDDLIARPTLVWLLEGAAVEKRTIEASYLTGGISWRADYVVTLSEKDDQANLAGWVTIDNRSGAAYRNATLKLVAGDVNRVQEQSTRFAKSVRAEAMAPAPQFQEEAFFEYHLYTLQRPSTIKENQTKQINLVTADAVPVKKEFLLKGESFYYQSPAGEVEKQKVGVFVEMENRKEHNLGMPLPKGIVRVYKRDAGGSLQFVGEDTIDHTPEKETVRVKLGDAFDVVGERKQTEWRKVASDTYESAFEIRLRNHKKEDITVKVVEPVPGDWQMLSSSHPHEKGDAFSAVFKVPVPKDGEATLVYRVRMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZI4</accession>
    <name>Q39ZI4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipid A biosynthesis acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0091"/>
    <dbReference type="EnsemblBacteria" id="ABB30340">
        <property type="protein sequence ID" value="ABB30340"/>
        <property type="gene ID" value="Gmet_0091"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0091"/>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049421_4_0_7"/>
    <dbReference type="OMA" id="IVDKMFV"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026649">
        <property type="entry name" value="MsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="324" mass="36460" checksum="78E27514969D48D5" modified="2005-11-22" version="1">MSMESPEHEAAPSPPRNRTKETIRAIKWRLGLVLFALVAIPVLLLPRRLAVGLGARGGRLVFLLMGKLRRKTVAHIESAYPYLGTLEEWDPAAGTPEEIARRTFANIGRTAVEIIKLYFGQGKGLVDRTELRGLEHVRAAKARGKGVIFITGHCDNWELVAHAFGTNAEGMAVVARRQKFEPLTRLLERLRNRHGNSIIYSEGAARQIFFRLRKNAAIGLLMDQSVPFHEGELVEFLGRKAWTTTMPALMAARTGAALVPGFGHREGDRHVVEFFPEIAPDPSGDPIATTRLLNRAIEQYIARHPDQWLWVYNRWKRVTREQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZL2</accession>
    <name>Q39ZL2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TrkA domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514187.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0063"/>
    <dbReference type="EnsemblBacteria" id="ABB30312">
        <property type="protein sequence ID" value="ABB30312"/>
        <property type="gene ID" value="Gmet_0063"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0063"/>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050982_0_1_7"/>
    <dbReference type="OMA" id="HIIVCGC"/>
    <dbReference type="OrthoDB" id="599322at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="3">
        <location>
            <begin position="109"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="4">
        <location>
            <begin position="243"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="351" mass="38742" checksum="2D61F6C4E86695CB" modified="2005-11-22" version="1">MDPVRHFKISIAVLLLLVSVGTAGYMAIEGWQFLDALYMTVITLGTVGFKEVHDLSNAGKIFTIGLIIFGVSVLGYIVGSLAQIMFEGQIQRIIGRKKVERKIEALHDHYIICGFGRIGALICREFAAKPMPFLVIEKHPEVHEKLHHEEYLHIRGDATEDETLLRAGIKRAKGLISVVTSDTENVYITLTARGLNPDLFILARSGEEGSELKLKRAGANKVVSPYVIGGSRMAQAILRPNVVDFIEIATGREHLDLQMEEIQIPEKSAFIGENLVTSGFRKETGVIIVGIKKASGKMVFNPNPHTKIEALDTLIVLGEPVAITKLEQLVACESCADTIIKKHRKEHPDHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZP4</accession>
    <name>Q39ZP4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine kinase PrkA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">prkA</name>
        <name evidence="2" type="ordered locus">Gmet_0030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513796.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0030"/>
    <dbReference type="EnsemblBacteria" id="ABB30280">
        <property type="protein sequence ID" value="ABB30280"/>
        <property type="gene ID" value="Gmet_0030"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0030"/>
    <dbReference type="eggNOG" id="COG2766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400497_0_0_7"/>
    <dbReference type="OMA" id="ERIMTEM"/>
    <dbReference type="OrthoDB" id="49410at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013153">
        <property type="entry name" value="Prk_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010650">
        <property type="entry name" value="PrkA_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08298">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06798">
        <property type="entry name" value="PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00763">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA_PrkA" evidence="1">
        <location>
            <begin position="7"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="686" mass="78065" checksum="A87138BBC06B2793" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PU8</accession>
    <name>Q39PU8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3521</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513678.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33726">
        <property type="protein sequence ID" value="ABB33726"/>
        <property type="gene ID" value="Gmet_3521"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3521"/>
    <dbReference type="HOGENOM" id="CLU_1747021_0_0_7"/>
    <dbReference type="OMA" id="SVEEQRM"/>
    <dbReference type="OrthoDB" id="1690571at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="145" mass="16583" checksum="D5DA02AD9BACCBA5" modified="2005-11-22" version="1">MDTTVIDEAIDKYVNERMKTGKKSAADRFISYAYLRYAGDELAEFLKKVRGLSRYYVDFLTLMENPFKGPELAWFASMITVGVVSCYMMGNEDTRIAGIFVFSGTLVHALSLLRMVAKKWREIGVMIAIYREIIEIVEREAKTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PX3</accession>
    <name>Q39PX3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513653.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33701">
        <property type="protein sequence ID" value="ABB33701"/>
        <property type="gene ID" value="Gmet_3496"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3496"/>
    <dbReference type="eggNOG" id="ENOG502ZXH8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1003849_0_0_7"/>
    <dbReference type="OMA" id="GHHNIPY"/>
    <dbReference type="OrthoDB" id="1319135at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223132" evidence="1">
        <location>
            <begin position="21"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="277" mass="30049" checksum="6447145C0DA9E2F1" modified="2005-11-22" version="1">MKKTVVAVVGMLLSATAAHAEHKLLITDVLEQKQMEAQARFEYSHTRGDVSSPIDGSGTRTTNILESVYSLGAGLGHGLEITASIPFVFNERAKTELSAVEAEFEKRDGFGDVALEAKYRLLGGEEEPFTVVTGLGLKFDTARKKDAGTGTTDVSPFIAASANLGHHYLPYAVYRATIRNHDMQDTHTLSLGLEKELNHTVTLDAKIDANFNTSTADMGANEDFVFEVSSYLQVAHNFYLIPSVAYTVATDATDKAAELRLGPADGFRGGLSLYYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PZ5</accession>
    <name>Q39PZ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Voltage-gated chloride channel, CBS domain pair-containing, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_3470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513921.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3470"/>
    <dbReference type="EnsemblBacteria" id="ABB33679">
        <property type="protein sequence ID" value="ABB33679"/>
        <property type="gene ID" value="Gmet_3470"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3470"/>
    <dbReference type="eggNOG" id="COG0038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015263_5_1_7"/>
    <dbReference type="OMA" id="LFEWKPR"/>
    <dbReference type="OrthoDB" id="1560952at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="Cl-channel_volt-gated"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="SSF81340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="486"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="7">
        <location>
            <begin position="550"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="613" mass="65911" checksum="25DA51E93373F7EC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PZ7</accession>
    <name>Q39PZ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltooligosyltrehalose synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513919.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3468"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33677">
        <property type="protein sequence ID" value="ABB33677"/>
        <property type="gene ID" value="Gmet_3468"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3468"/>
    <dbReference type="eggNOG" id="COG3280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005045_1_0_7"/>
    <dbReference type="OMA" id="WTVVEKI"/>
    <dbReference type="OrthoDB" id="217555at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11336">
        <property type="entry name" value="AmyAc_MTSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012767">
        <property type="entry name" value="Trehalose_TreY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02401">
        <property type="entry name" value="trehalose_TreY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="13"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="994" mass="113343" checksum="2DB609AD5A489DCE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q19</accession>
    <name>Q39Q19_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase related to nitroreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514674.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3446"/>
    <dbReference type="EnsemblBacteria" id="ABB33655">
        <property type="protein sequence ID" value="ABB33655"/>
        <property type="gene ID" value="Gmet_3446"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3446"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_0_7"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="184" mass="19397" checksum="EDDF15BB0740A2B6" modified="2005-11-22" version="1">MNVTEAITARKSVRAYLDTPVPADVLEKIVEAGRWAPNAGPIQLSVVRNAELRKKINDVTLDAMAHSGIEFLRQRAALPGYQPLYDAPVLILISGPVTIPISAVNAAVSAENMLLQATGAGLGSCFLLSLTLAFDGADGSDLLQKAGIPDGYRVQCAVIVGYAAPESKFTTGERTIKGAVSYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q20</accession>
    <name>Q39Q20_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc-dependent amidohydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514671.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33654">
        <property type="protein sequence ID" value="ABB33654"/>
        <property type="gene ID" value="Gmet_3443"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3443"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023257_6_0_7"/>
    <dbReference type="OMA" id="RAHACGH"/>
    <dbReference type="OrthoDB" id="796259at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11014">
        <property type="entry name" value="PTHR11014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005962">
        <property type="entry name" value="Pept_M20D_amidohydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="2">
        <location>
            <begin position="152"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="367" mass="39744" checksum="AC7DFD3EE071AD3F" modified="2005-11-22" version="1">MNSVRKIRQISGVVGILKNGDGPTVMLRADMDAMPMKEDTGVPYASTKEGANAKGETVPVAHSCGHDMHTSWLLGAATVLSLARETWHGTLMTVFQPAEETAQGSQAMLDDGLMERFPRPDVILGQHLLPFRAGTVGYHSGQILTSGDSLLVRFFGKGAHGGMPQNGIDPIVMAASAVLRLQTIVSREISPQAQVVVTVGEFHGGTAENIIPAEAYIKLNVRTTDEAVRDHVLAAIRRICVAEARASNAPKDPEFEEINNYPLTVNDAEVTRKVADAFRGQFGDQLFEAPSQGASEDFGRFGQAWKSPYMYWFVGGSDPEKYDQAVREGGVERLPGPHSPFWAPVLYPTLQTGLETMLTAAGVWLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q23</accession>
    <name>Q39Q23_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3439</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514667.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3439"/>
    <dbReference type="EnsemblBacteria" id="ABB33651">
        <property type="protein sequence ID" value="ABB33651"/>
        <property type="gene ID" value="Gmet_3439"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3439"/>
    <dbReference type="HOGENOM" id="CLU_2206269_0_0_7"/>
    <dbReference type="OMA" id="CRRTPIE"/>
    <dbReference type="OrthoDB" id="1938054at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="4"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="107" mass="12011" checksum="6ACB3BD69985F2B2" modified="2005-11-22" version="1">MEERSCRRTPIEVGCWLVELDGASCLYTFDISENGVSIITKDPRPVGQVVKLQFYTSRSAQAVTLDARVVWSRLEPEGGMGLAFSDLDAEKRGVLRSFMAELKKRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q44</accession>
    <name>Q39Q44_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell polarity determinant GTPase-activating protein MglB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mglB</name>
        <name evidence="2" type="ordered locus">Gmet_3418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514225.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3418"/>
    <dbReference type="EnsemblBacteria" id="ABB33630">
        <property type="protein sequence ID" value="ABB33630"/>
        <property type="gene ID" value="Gmet_3418"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3418"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128755_0_0_7"/>
    <dbReference type="OMA" id="KEALWAP"/>
    <dbReference type="OrthoDB" id="1584836at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037587">
        <property type="entry name" value="LAMTOR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13323">
        <property type="entry name" value="PTHR13323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="16"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="163" mass="18134" checksum="FA28572910BD01A2" modified="2005-11-22" version="1">MADPQMVMYDEEFRLINLAIEKLLREANAKVIFLVDKNGQLIAGCGETERFDTTSLASLTAGNIAATGGLAKLIGEKEFSILFHEGEKDNLHISIVGGRVILVVLFDTRSSLGLVRLRVKKASEELTAIFDRLMKKAEEKERSGIQEFPFAEITDDDIDNLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q77</accession>
    <name>Q39Q77_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3385</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M20A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512611.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3385"/>
    <dbReference type="DNASU" id="3740700"/>
    <dbReference type="EnsemblBacteria" id="ABB33597">
        <property type="protein sequence ID" value="ABB33597"/>
        <property type="gene ID" value="Gmet_3385"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3385"/>
    <dbReference type="eggNOG" id="COG1473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031812_1_0_7"/>
    <dbReference type="OMA" id="EHHAHGV"/>
    <dbReference type="OrthoDB" id="1015417at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="SSF55031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="M20_dimer" evidence="3">
        <location>
            <begin position="167"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="387" mass="41374" checksum="F829FE86A8E328BE" modified="2005-11-22" version="1">MDLDRIKGEIVAFVEGRKSEFAAIAEDLYLHPETGLNEVRSSALLADFLEREGFRVERGIAGLPTAFRAETGEGGPVIAFMAEMDALPVMGHACGHNVIAAAAVGAATALRSILPPDAARIVVLGTPAEEMGIGKVDMIANGAFDGVEFALMVHPSSRRYVIKHYLGLARVRFTFFGKPAHAAAYPEEGINALDGVIQTFNGISALRQQLRQDVRVHGIITEGGVAPNIIPERASAHFYVRADDLAELERAKARVLACAEGAALATGCRLQVDADPRIMAPLKVNRIFSDLYSAQLAYLDLQESENQPDKNKGSSDIGNVSQIVPTIHPHVPIGDGINIHSEAFARATVSGKGKAAVAEGATALALTAAELAARPDIREEIWREFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QC8</accession>
    <name>Q39QC8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidophosphoribosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512557.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3333"/>
    <dbReference type="EnsemblBacteria" id="ABB33546">
        <property type="protein sequence ID" value="ABB33546"/>
        <property type="gene ID" value="Gmet_3333"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3333"/>
    <dbReference type="eggNOG" id="COG1040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054549_0_0_7"/>
    <dbReference type="OMA" id="RYNQSAL"/>
    <dbReference type="OrthoDB" id="1937725at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044005">
        <property type="entry name" value="DZR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18912">
        <property type="entry name" value="DZR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DZR_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Pribosyltran" evidence="1">
        <location>
            <begin position="159"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="242" mass="26083" checksum="24CF1999A019A90E" modified="2005-11-22" version="1">MELLRAFLDVLFPPLCHLCKAPVPGAGPLHLCDACLGAMTPITSPLCPVCGVPHRTEGGIDHLCGSCMLTPPPFDGVRGALLFDGPLQELIHRHKYGHKVHLRRPLALLAIRHLTPFVQSVAPDVIIPVPLHRSRLRERGFNQAVLVGAVLSREWRLPLLRHTLRRVRPTVAQVTLSARERRANVRGAFAVSGPAGIAGRRVLLMDDVVTTGSTVAECARVLKDAGASAVFVITVALAPPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QE6</accession>
    <name>Q39QE6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type VI secretion system ATPase TssH, putative chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">tssH</name>
        <name evidence="9" type="ordered locus">Gmet_3315</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512539.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3315"/>
    <dbReference type="EnsemblBacteria" id="ABB33528">
        <property type="protein sequence ID" value="ABB33528"/>
        <property type="gene ID" value="Gmet_3315"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3315"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_1_0_7"/>
    <dbReference type="OMA" id="CEDFTAK"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017729">
        <property type="entry name" value="ATPase_T6SS_ClpV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03345">
        <property type="entry name" value="VI_ClpV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="8">
        <location>
            <begin position="10"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="430"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="878" mass="95099" checksum="BC19CC8B3FE76A99" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QR0</accession>
    <name>Q39QR0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal silencing factor RsfS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsfS</name>
        <name evidence="3" type="ordered locus">Gmet_3201</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with ribosomal protein L14 (rplN).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Iojap/RsfS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366160.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3201"/>
    <dbReference type="EnsemblBacteria" id="ABB33414">
        <property type="protein sequence ID" value="ABB33414"/>
        <property type="gene ID" value="Gmet_3201"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3201"/>
    <dbReference type="eggNOG" id="COG0799">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092688_2_2_7"/>
    <dbReference type="OMA" id="VVHVFQK"/>
    <dbReference type="OrthoDB" id="1990650at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:mature ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090071">
        <property type="term" value="P:negative regulation of ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01477">
        <property type="entry name" value="Iojap_RsfS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004394">
        <property type="entry name" value="Iojap/RsfS/C7orf30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21043">
        <property type="entry name" value="PTHR21043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00090">
        <property type="entry name" value="rsfS_iojap_ybeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="131" mass="14658" checksum="8788BC5D4222AA90" modified="2005-11-22" version="1">MTDKPTLAPLERALECARLALDKKALDVKILKIGRLSSIADYLVLASGRSDRQVQAIADSVKKGLKKYGKALDVEGLKEGNWVVIDYGDVLVHVFQEEVRRYYNLDELWSSAPTSEIPDAWLWEGKEGIPT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QR6</accession>
    <name>RL21_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplU</name>
        <name type="ordered locus">Gmet_3195</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to 23S rRNA in the presence of protein L20.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L20.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512633.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QR6"/>
    <dbReference type="SMR" id="Q39QR6"/>
    <dbReference type="STRING" id="269799.Gmet_3195"/>
    <dbReference type="EnsemblBacteria" id="ABB33408">
        <property type="protein sequence ID" value="ABB33408"/>
        <property type="gene ID" value="Gmet_3195"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3195"/>
    <dbReference type="eggNOG" id="COG0261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061463_3_2_7"/>
    <dbReference type="OMA" id="HRQEITR"/>
    <dbReference type="OrthoDB" id="1949059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01363">
        <property type="entry name" value="Ribosomal_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036164">
        <property type="entry name" value="L21-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028909">
        <property type="entry name" value="L21p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001787">
        <property type="entry name" value="Ribosomal_L21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018258">
        <property type="entry name" value="Ribosomal_L21_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21349">
        <property type="entry name" value="PTHR21349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00829">
        <property type="entry name" value="Ribosomal_L21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141091">
        <property type="entry name" value="SSF141091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00061">
        <property type="entry name" value="L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01169">
        <property type="entry name" value="RIBOSOMAL_L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000269321" description="50S ribosomal protein L21">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01363"/>
        </source>
    </evidence>
    <sequence length="102" mass="11220" checksum="31C34977B7FA1F94" modified="2005-11-22" version="1">MYAVVRTGGKQYKVSEGDFLKVEKLEGAVGDTIELKDILMVGGETVKIGTPLVPSASVVGKIVEQGKDKKILVFKSKKRKDSKKLRGHRQPRTVLKIEKING</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QV6</accession>
    <name>Q39QV6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminomethyltransferase</fullName>
            <ecNumber evidence="3">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gcvT</name>
        <name evidence="9" type="ordered locus">Gmet_3155</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GcvT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513871.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3155"/>
    <dbReference type="EnsemblBacteria" id="ABB33368">
        <property type="protein sequence ID" value="ABB33368"/>
        <property type="gene ID" value="Gmet_3155"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3155"/>
    <dbReference type="eggNOG" id="COG0404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007884_10_2_7"/>
    <dbReference type="OMA" id="MPVQYPA"/>
    <dbReference type="OrthoDB" id="282830at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006223">
        <property type="entry name" value="GCS_T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GCST/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GCV_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCV_T_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="PTHR43757"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="SSF101790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00528">
        <property type="entry name" value="gcvT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GCV_T" evidence="7">
        <location>
            <begin position="10"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="GCV_T_C" evidence="8">
        <location>
            <begin position="281"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="362" mass="39642" checksum="3842369DAB642A75" modified="2005-11-22" version="1">MEPLKNTPLCAEHEKLNALMAPFGGWNMPIQYEGIIAEHRWCREKAALFDICHMGEFHFKGDIVASGLEDVFTFSVKSIPVGRSRYGFLLNENGGVIDDLIVFRLADDEAMVVVNAATIEKDFAAISARLCGGEFRDISAETGKLDLQGPLSREVLSGVVGPEIAAIPYFKFIRTKVLGVDAIVSRTGYTGELGYEIFLPAEKSAELWTRFLSDERVKPAGLGARDVLRLEMGYSLYGSDIDEATTPLEAGLEAFVNFDKAFVGKEALLKQRAEGVKRLKVAFDVTSRRSPRHDYEIHFEGERVGTVTSGVFSPMLGCGIGMGYVNPSVATLGAPLTITHEKVSMEATVVELPFYRGGSLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QZ7</accession>
    <name>Q39QZ7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar hook-basal body complex protein FliE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">fliE</name>
        <name evidence="4" type="ordered locus">Gmet_3113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the FliE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514288.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3113"/>
    <dbReference type="EnsemblBacteria" id="ABB33327">
        <property type="protein sequence ID" value="ABB33327"/>
        <property type="gene ID" value="Gmet_3113"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3113"/>
    <dbReference type="eggNOG" id="COG1677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147249_3_0_7"/>
    <dbReference type="OMA" id="KLMLEIR"/>
    <dbReference type="OrthoDB" id="1581972at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00724">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001624">
        <property type="entry name" value="FliE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34653">
        <property type="entry name" value="PTHR34653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02049">
        <property type="entry name" value="FliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01006">
        <property type="entry name" value="FLGHOOKFLIE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00205">
        <property type="entry name" value="fliE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="101" mass="10693" checksum="1914761CAF937DD2" modified="2005-11-22" version="1">MIDGIESGIGLGQAFPEIGAKSAKPANMAGDAGKFFGELVSKVNELQSQSDSAVQALATGESQGLHEVMIAMEKSSLAFQFLGQVRNKAIDAYNEVMRMQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R49</accession>
    <name>Q39R49_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3060"/>
    <dbReference type="EnsemblBacteria" id="ABB33275">
        <property type="protein sequence ID" value="ABB33275"/>
        <property type="gene ID" value="Gmet_3060"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3060"/>
    <dbReference type="eggNOG" id="ENOG502ZB6I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_703606_0_0_7"/>
    <dbReference type="OMA" id="CESRHAD"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045941">
        <property type="entry name" value="DUF6361"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19888">
        <property type="entry name" value="DUF6361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="405" mass="45645" checksum="1D3C4C6B25660820" modified="2005-11-22" version="1">MLEPALGWTVLSRDALRRAEAKLRNDEQGVRDEVGFLALHQGYANRFFPGTSVLQTRLRYILFVPWLYEEARNRNLSETPERAISRMEISLAGRLKRTGQDGVIGGRSYPGPTSQPASMVYWTALGTWGILRPTMSGTIPGRAVVNRMLVKRTMVPQLVDDDGEPTEEGLELFSSIPRPPKEWTDKSASLTFDIQPDEAAFLRRHLSAVTRPGTPDKTSLLSSLVERALPVEEIQSPWDRTVMAIADTDDRAALRRAGRASALAAIGRAIYSALVEELRERDGNETPSHHRKQILKTIPQYITPAKNLDISSVEQDIPGIPPQFTTLLRETQLWLNKGGHNYLDLLEVYQKAEIRRKGTRSRLPSTPAAKKRRAEWGIEDNTLAEPLSYRWYNVRRILSDLRSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R62</accession>
    <name>Q39R62_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integrase core domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3047</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513607.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3047"/>
    <dbReference type="EnsemblBacteria" id="ABB33262">
        <property type="protein sequence ID" value="ABB33262"/>
        <property type="gene ID" value="Gmet_3047"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3047"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017991_4_0_7"/>
    <dbReference type="OMA" id="PEYGGHI"/>
    <dbReference type="OrthoDB" id="1637053at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015378">
        <property type="entry name" value="Transposase-like_Mu_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09299">
        <property type="entry name" value="Mu-transpos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="221"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="636" mass="72792" checksum="98F1594302DE8D42" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RH7</accession>
    <name>Q39RH7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Menaquinol oxidoreductase complex Cbc5, cytochrome b subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cbcB</name>
        <name evidence="6" type="ordered locus">Gmet_2929</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HupC/HyaC/HydC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512865.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2929"/>
    <dbReference type="EnsemblBacteria" id="ABB33147">
        <property type="protein sequence ID" value="ABB33147"/>
        <property type="gene ID" value="Gmet_2929"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2929"/>
    <dbReference type="eggNOG" id="COG4117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097472_1_0_7"/>
    <dbReference type="OMA" id="ITGWEEV"/>
    <dbReference type="OrthoDB" id="923657at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000516">
        <property type="entry name" value="Ni-dep_Hydgase_cyt-B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00161">
        <property type="entry name" value="NIHGNASECYTB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="5">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="224" mass="25875" checksum="1A2C1E1FF6D0FCEB" modified="2005-11-22" version="1">MSAHNEQALHTEHAEHAEYIYLTPMPVRIWHWINALGIVTLCVTGLQIRFPEYVNIFGTYKAAIRLHNTAGITVSIFYAIWFAYYLIVKGNLFKLYVPNTYDIKMGIFRQVLYYFYYFFKGGPSPHHATPDDKFNPMQKVAYMGLMLVLLPLVILTGILILNVAPLREMIMLLGGLKILVSAHFLIACCFCAFLFVHIYLATMGHTMLAHFKPMWDGWEEVKHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RL6</accession>
    <name>Q39RL6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, YqgM-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2890"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33108">
        <property type="protein sequence ID" value="ABB33108"/>
        <property type="gene ID" value="Gmet_2890"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2890"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_2_7"/>
    <dbReference type="OMA" id="FVFDQHD"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="33"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="409" mass="45251" checksum="EF26035B37B229EC" modified="2005-11-22" version="1">MTSFSPVPGPRSPVPRTLRVLMVAPTPFFADRGCHVRIYEEARALMACGHEVRIATYHLGRDMPGIATDRTVRIPWYRKLSAGPSWHKPYLDILLFVTALRAARRMRPDLIHAHLHEGAFLGVFLKRLVGVPLLFDCQGSLTGELADHGFARQGSLLCRFFARLEGWINRNADAIITSSGAGRDDLVGKWGVPARKVTAFMDGVDTAVFRPYPRDEVRRKLGIASHAPLVVFLGVLNRYQGIDLLLSAMVILKAKGSPVRFLVMGFPEGGYREKARELGVDDMVTFPGRIDYAKAPLYLSAGDLAVSPKVSLTEANGKLFNYMACGLPTVVFDTPINREILGDAGVYARFGDAVDLAARIDSLAGDVEERARLSQLGREHAENNHSWHARGMELSEVYRHLVILLAARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RZ2</accession>
    <name>Q39RZ2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="primary">lpdA-1</name>
        <name evidence="17" type="ordered locus">Gmet_2764</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511697.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2764"/>
    <dbReference type="EnsemblBacteria" id="ABB32982">
        <property type="protein sequence ID" value="ABB32982"/>
        <property type="gene ID" value="Gmet_2764"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2764"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_3_7"/>
    <dbReference type="OMA" id="DAKYGEW"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="16">
        <location>
            <begin position="6"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="15">
        <location>
            <begin position="358"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="194"/>
            <end position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="330"/>
            <end position="333"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="44"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB32982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="477" mass="50654" checksum="3D5C37FF3DCFF9A1" modified="2005-11-22" version="1">MSEELYDLIVIGAGPGGYVAAIRAAQLGMSVAVVEKRSALGGVCLNEGCIPSKALLDSSELFALARDRFAGHGIAIDPPRLDLARMMARKDDVVKKLTDGVAFLFKKNKIARVQGTARLTGERDGAHGVDVEGGDQGPGTGDREKQTLRGKRVLLATGSEAAVIPFMPFDGELVVSAREALSFDRVPEHLLVVGAGYVGLELGSVWRRLGSQVTVVEMLPKMLPNTDGQVADTLMGSLKKQGIVFRMETKVTGFAKRDGKAAVTVEAGGATEEIVCDRVLVAAGRRPLTAGLGLEELGVRLEAGRIAVDDNYQTSLRGIYAIGDLIHGPMLAHKAMAEGEVFAERLTGQASVVDYAYIPGIVYTWPEAAGVGRTEEELKTEGVEYRVGKFPFMANGRAKCMDETEGFVKILATPDTGRVLGIHVIGPRASDVIAEAVTVMTYGGSAADIAMTFHAHPTLAEAMKEAALDVEKRAIHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S19</accession>
    <name>Q39S19_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_2737</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511722.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2737"/>
    <dbReference type="EnsemblBacteria" id="ABB32955">
        <property type="protein sequence ID" value="ABB32955"/>
        <property type="gene ID" value="Gmet_2737"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2737"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_7"/>
    <dbReference type="OMA" id="LHYEENR"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="208"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="300"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="248"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="523" mass="57723" checksum="D731C0120D4C5666" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S90</accession>
    <name>Q39S90_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511795.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2666"/>
    <dbReference type="EnsemblBacteria" id="ABB32884">
        <property type="protein sequence ID" value="ABB32884"/>
        <property type="gene ID" value="Gmet_2666"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2666"/>
    <dbReference type="HOGENOM" id="CLU_2329737_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="98" mass="10717" checksum="3382E0D97117A3BD" modified="2005-11-22" version="1">MVKKVFKLVLAVIILMFLVGVADGYRTKKKLVGYCRETAAGTLLAVAKEKALQSGFRFFDSTSPTKALVTASGVMGRYVCEIEHDGKQVVKATLLFKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SA2</accession>
    <name>Q39SA2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511807.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2654"/>
    <dbReference type="EnsemblBacteria" id="ABB32872">
        <property type="protein sequence ID" value="ABB32872"/>
        <property type="gene ID" value="Gmet_2654"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2654"/>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801139_0_0_7"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223329" evidence="1">
        <location>
            <begin position="25"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="232"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="370" mass="39942" checksum="EEC2105979916EDA" modified="2005-11-22" version="1">MKKAIRQLVITSLFALLTVSPLLAQEEIPEAARERFKAGFAIIEKADSPAGFRAAMDEFEAAAALAPRWPDIHYNLAKVAAETDKPAKAINEYRAYLALAPEAADRAAVEGDIARMKEMIARKRKLGLPGVVFAAMPDGIWVMELAPGSRVGKTLLRKGYKILAVEGESVVGAKLDGFFRAIETQSAKVAAAKSEEKKQPGQIPAGFRSEMGFIRSQKFMRTTQPNAAGNAVEETGPAIAFTVISPGSTDTGKLFFKQSMFRSSVIEIEEDEFEDEVIKERLPVVVTFWGSDCGPCQDFVPAVEAQSARYAGKVKFVNVNVNENRKLAGQLAIKGVPAMMVYKGGSPVSTTTGRIDNAKLAELLQGVAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SA6</accession>
    <name>Q39SA6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine-5'-phosphate oxidase-related FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511812.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2650"/>
    <dbReference type="EnsemblBacteria" id="ABB32868">
        <property type="protein sequence ID" value="ABB32868"/>
        <property type="gene ID" value="Gmet_2650"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2650"/>
    <dbReference type="eggNOG" id="COG3576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163878_0_0_7"/>
    <dbReference type="OMA" id="YAWARGA"/>
    <dbReference type="OrthoDB" id="1650305at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="123" mass="13052" checksum="9D96F64389DFE101" modified="2005-11-22" version="1">MIPEKMLQVLKHEGVVAIATQGDGGPHLVNTWNSYIQITQDGKLLIPAGYMNTTEANLAKDSRCLITVGSREVEGAHGPGTGFLVEGTAVFVTSGPLFDVVKGKFPWARAALEVTITSATQTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SF9</accession>
    <name>Q39SF9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ech-hydrogenase-related complex, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ehrS-1</name>
        <name evidence="2" type="ordered locus">Gmet_2596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511865.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2596"/>
    <dbReference type="EnsemblBacteria" id="ABB32815">
        <property type="protein sequence ID" value="ABB32815"/>
        <property type="gene ID" value="Gmet_2596"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2596"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_5_1_7"/>
    <dbReference type="OMA" id="NACEADL"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="1">
        <location>
            <begin position="127"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="244" mass="26321" checksum="9903937D6BB01513" modified="2005-11-22" version="1">MFRAIASRIKQGHRTTPYPAAPLQMPERFRGYPLVSPANEASEATCPYGAYSKESGGCLDMGKCLFCAECPVGTIQFTTDYQLAVTNRDHLLVHPGSEHHHARPLPPDLRRLFGRSLKFREVSAGGCNACEADTNVLSTIGWDLGRFGIQFVASPRHADGLWVTGPVTEHMAKALLTTYEAIPDPKIVVACGACAINGGPYIDTPQVCNGVDSIVPVDLYIPGCPPHPATILDGLLRILNKIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SJ0</accession>
    <name>Q39SJ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase, IS110 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513469.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2565"/>
    <dbReference type="EnsemblBacteria" id="ABB32784">
        <property type="protein sequence ID" value="ABB32784"/>
        <property type="gene ID" value="Gmet_2565"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2565"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036902_1_2_7"/>
    <dbReference type="OMA" id="WTPDEEQ"/>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="2">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="358" mass="40016" checksum="343D7E429EBAC0DB" modified="2005-11-22" version="1">MAKISLAGLQQFVVGFEDETFHVGIDVHKRSYHIALHRCDGRALSLVSPASPQAIIELLTGLNIRVGAVAYESGPTGFSLARMLFAAGFPVIVAAPSKIPRSVTPGAKCDRLDCLKLANYAAKGMLKSIAIPTQQEEARRTLLRRRHMLVDDVRRCKQRIKGLLLFLGVDEPKELEHWQIGVDAVLLALPIDSAAHMTLQSYLRELTFNQEELRRIEHQLKSLTKTEELANTMTCLQSIPGVGPVVATTFAMELFRPERFKRPEEVASYLGLAPVVRQSGNKSSSGRLVPAGQTRLRSLLIEAAWMWRSRDSYAENLYRRLLGKTGIAQKAIAVVARRLAIILWRLYVEQRPYRIVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SJ5</accession>
    <name>Q39SJ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513474.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2560"/>
    <dbReference type="EnsemblBacteria" id="ABB32779">
        <property type="protein sequence ID" value="ABB32779"/>
        <property type="gene ID" value="Gmet_2560"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2560"/>
    <dbReference type="eggNOG" id="ENOG502ZEBJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192877_1_0_7"/>
    <dbReference type="OMA" id="MEIFGGF"/>
    <dbReference type="OrthoDB" id="2091171at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="63" mass="7306" checksum="7BA7484AB026E72A" modified="2005-11-22" version="1">MEIVGGFMVMMWILGLILTVVWLVMPFVVLAIKGKVEQNHVLLESIDRRLAAIEDRLREEVRQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SM2</accession>
    <name>CMOB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA U34 carboxymethyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cmoB</name>
        <name type="ordered locus">Gmet_2531</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-hydroxyuridine(34) in tRNA + carboxy-S-adenosyl-L-methionine = 5-carboxymethoxyuridine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:52848"/>
            <dbReference type="Rhea" id="RHEA-COMP:13381"/>
            <dbReference type="Rhea" id="RHEA-COMP:13383"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
            <dbReference type="ChEBI" id="CHEBI:136877"/>
            <dbReference type="ChEBI" id="CHEBI:136879"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. CmoB family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514520.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SM2"/>
    <dbReference type="SMR" id="Q39SM2"/>
    <dbReference type="STRING" id="269799.Gmet_2531"/>
    <dbReference type="EnsemblBacteria" id="ABB32752">
        <property type="protein sequence ID" value="ABB32752"/>
        <property type="gene ID" value="Gmet_2531"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2531"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052665_0_0_7"/>
    <dbReference type="OMA" id="CEWRSDF"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01590">
        <property type="entry name" value="tRNA_carboxymethyltr_CmoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010017">
        <property type="entry name" value="CmoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027555">
        <property type="entry name" value="Mo5U34_MeTrfas-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08003">
        <property type="entry name" value="Methyltransf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00452">
        <property type="entry name" value="TIGR00452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000313920" description="tRNA U34 carboxymethyltransferase">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="180"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>carboxy-S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:134278"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01590"/>
        </source>
    </evidence>
    <sequence length="323" mass="36528" checksum="01CE8922E98848C6" modified="2005-11-22" version="1">MSWYDALFPHLAAMGQERWAEQLQVTLSESQLLQRYGDMPGWLSALQALPELHPSRIALQDTVTIGSGADLCSVTREDLILGLQAFHPWRKGPYSVFGIEIDTEWRSDWKWERLLPHIQPLAGRKVLDVGCGNGYHGWRMRGAGADFVLGIEPFLVSVMQFQVMQRYLRDPRHHVIPIGIEDVPPNPACFDSVFSMGVLYHRRSPLDHLLELKGCLRPGGELILETLIVEGGQETIFMPPGRYAKMRNVWFLPSIAALTLWLQRCGFTEIACVDATRTTCEEQRATEWMRFESLADFLDPDDGGKTMEGHPAPLRAIFTATKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SQ8</accession>
    <name>Q39SQ8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="12">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">trpB</name>
        <name evidence="14" type="synonym">trpB2</name>
        <name evidence="14" type="ordered locus">Gmet_2493</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514653.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2493"/>
    <dbReference type="EnsemblBacteria" id="ABB32716">
        <property type="protein sequence ID" value="ABB32716"/>
        <property type="gene ID" value="Gmet_2493"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2493"/>
    <dbReference type="eggNOG" id="COG1350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042858_1_0_7"/>
    <dbReference type="OMA" id="MLHQTII"/>
    <dbReference type="OrthoDB" id="912282at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006316">
        <property type="entry name" value="Trp_synth_b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF6">
        <property type="entry name" value="PTHR48077:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500824">
        <property type="entry name" value="TrpB_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01415">
        <property type="entry name" value="trpB_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="13">
        <location>
            <begin position="75"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="451" mass="49064" checksum="31E64AF54AE864D9" modified="2005-11-22" version="1">MQTKILLDESRIPTHWYNIIPDMPGPLAPVINPRTLQPVTPDDLLPIFPMAIIEQEVSGERWIPIPEEVREIYRLWRPSPLYRARRLEQALGTPAKIYYKYEGVSPAGSHKPNSAIPQAFYNKQAGIRRLATETGAGQWGSSLALACSMFGLECTVYMVKVSCTQKPYRKSMMQLWGANVIPSPSEFTNAGRAILAHDPDSNGSLGIAISEAVEDAVSRPDTNYALGSVLNHVCLHQTVIGQEAKEQLALAGDYPDVVIACCGGGSNFAGTAFPFLADRAAGKNVRCLAVEPASCPTLTKGVYAFDYGDTAKMAPIAMMYTLGHDFMPPGIHAGGLRYHGESALVSQLHHAGLIEAKSYRQNACFEAAHLFARSEGIVPAPESSHAVRAAIDEAVLAKEEGKEKTILFCLSGHGQLDMGAYDAYLSGGLEDFEYPEEMIRESLARLPKVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SU9</accession>
    <name>Q39SU9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512450.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2450"/>
    <dbReference type="EnsemblBacteria" id="ABB32675">
        <property type="protein sequence ID" value="ABB32675"/>
        <property type="gene ID" value="Gmet_2450"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2450"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1862316_0_0_7"/>
    <dbReference type="OMA" id="LWCFDPD"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyoxalase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="136" mass="15380" checksum="2DCF97F25F3883BC" modified="2005-11-22" version="1">MAGTGASIQLTVVDLDATEAFYAGILELDVMRALTARGAPEHLILKHDRLEIIFVQEDAVVREHPALEERFDEFPKGVGLTIHVKVDDIVETYEAVAEEELEIFYPLETKPYGIKEFWCFDPDGYLVVVEEARRGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-04-17" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T29</accession>
    <name>YBEY_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endoribonuclease YbeY</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ybeY</name>
        <name type="ordered locus">Gmet_2370</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the endoribonuclease YbeY family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366044.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T29"/>
    <dbReference type="SMR" id="Q39T29"/>
    <dbReference type="STRING" id="269799.Gmet_2370"/>
    <dbReference type="EnsemblBacteria" id="ABB32595">
        <property type="protein sequence ID" value="ABB32595"/>
        <property type="gene ID" value="Gmet_2370"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2370"/>
    <dbReference type="eggNOG" id="COG0319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106710_3_3_7"/>
    <dbReference type="OMA" id="RMRIHPL"/>
    <dbReference type="OrthoDB" id="1830156at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00009">
        <property type="entry name" value="Endoribonucl_YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023091">
        <property type="entry name" value="MetalPrtase_cat_dom_sf_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002036">
        <property type="entry name" value="YbeY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46986">
        <property type="entry name" value="PTHR46986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02130">
        <property type="entry name" value="YbeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00043">
        <property type="entry name" value="TIGR00043"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000284213" description="Endoribonuclease YbeY">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00009"/>
        </source>
    </evidence>
    <sequence length="150" mass="16766" checksum="D24247C2F4D5F889" modified="2005-11-22" version="1">MKVAIANRQRRHPIGTPRLRKVAERILSALGYPDSELSVVITGDLGIRRVNREYLHKDRPTNVISFAMAEGEFGALNPAMLGDVIISADTAAREAEEGGVSFWSRLCFLLLHGILHITGYDHERSGEAEARRMEAKEREIFAILEREGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T51</accession>
    <name>Q39T51_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">3-deoxy-D-manno-octulosonic acid transferase</fullName>
            <shortName evidence="9">Kdo transferase</shortName>
            <ecNumber evidence="3 9">2.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 9">Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">kdtA</name>
        <name evidence="11" type="ordered locus">Gmet_2348</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) = alpha-Kdo-(2-&gt;6)-lipid IVA + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28066"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58603"/>
            <dbReference type="ChEBI" id="CHEBI:60364"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.4.99.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Bacterial outer membrane biogenesis; LPS core biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.12" evidence="3 9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513272.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2348"/>
    <dbReference type="CAZy" id="GT30">
        <property type="family name" value="Glycosyltransferase Family 30"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32573">
        <property type="protein sequence ID" value="ABB32573"/>
        <property type="gene ID" value="Gmet_2348"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2348"/>
    <dbReference type="eggNOG" id="COG1519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036146_2_1_7"/>
    <dbReference type="OMA" id="FIKYEFW"/>
    <dbReference type="OrthoDB" id="1163086at2"/>
    <dbReference type="UniPathway" id="UPA00958"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043842">
        <property type="term" value="F:Kdo transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007507">
        <property type="entry name" value="Glycos_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038107">
        <property type="entry name" value="Glycos_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039901">
        <property type="entry name" value="Kdotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42755">
        <property type="entry name" value="PTHR42755"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04413">
        <property type="entry name" value="Glycos_transf_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_N" evidence="10">
        <location>
            <begin position="35"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="8">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR639901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="436" mass="47671" checksum="0C76ADA6888E092F" modified="2005-11-22" version="1">MIFLVYDILLLLLSPLILIHHAWRTVSRGRSFAGFGERFGCIAPESLARVAGKGPIWVHAVSVGETMAVKPLLRELKRRFPERPLVLSSVTETGRSVAVTIPEADLVVYFPFDFGFAVARALRLVAPSLVIVVETEIWPNFLRHARRTGIPSVMVNGRISDRSFPRYLRFSRFFAPILNNLSALCMQSSEDARRIIAVGAPAERVHVTRNLKYDLPVRSLTPAERQELLCSYRLPAGALIITAGSTHAGEEEVVADIYARLAGERSDLFLVLVPRHPERAVEVGTLLEGKGIPFVRRSALDKVQEQPRGGVLLVDTIGELMKLYALSDVVFVGGSLVPVGGHNLLEPASVGAPVLFGPHMHNFREITALVLGAGAGEQVNDHGELEATLRRLLADEPARRSMGENGIRLMADQGGAAARHLEIIGPLIERGSEVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T59</accession>
    <name>Q39T59_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acetate--coenzyme A ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acsA</name>
        <name evidence="3" type="ordered locus">Gmet_2340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513280.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2340"/>
    <dbReference type="EnsemblBacteria" id="ABB32565">
        <property type="protein sequence ID" value="ABB32565"/>
        <property type="gene ID" value="Gmet_2340"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2340"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_10_7"/>
    <dbReference type="OMA" id="AIKASWP"/>
    <dbReference type="OrthoDB" id="141801at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="23"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="438"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="539" mass="59489" checksum="14BAFE5C0D4A6D48" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T96</accession>
    <name>Q39T96_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GAF domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2303</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514495.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2303"/>
    <dbReference type="EnsemblBacteria" id="ABB32528">
        <property type="protein sequence ID" value="ABB32528"/>
        <property type="gene ID" value="Gmet_2303"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2303"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086365_0_0_7"/>
    <dbReference type="OMA" id="MVHSRGE"/>
    <dbReference type="OrthoDB" id="1241365at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="2">
        <location>
            <begin position="124"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="64"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="277" mass="31202" checksum="243CB35F867D740C" modified="2005-11-22" version="1">MSMDDKSDEKGMHVRADEFLQLFKKGAEFTQDLLKENERLRYRIFQLEEHQRKGGAPASLVEENRLLAARIEELEREKDEILGRIRQIEAENNDFATRYVEIEEENNNLANLYIASYQLHSILDFDDVLKVITEIIINLIGAEEFAVMLIDEKAGLLGAVAAEGISLDDVPKVRPGEGTIGAIAATGESHFLEDPAGYVRDLSNPMVCIPLKIKDQVIGVIVIYKLLIQKKAFVPVDYELFTLLAGHAATAIFSSRLYSDSERKRSTMQGFINLLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TB7</accession>
    <name>Q39TB7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32507">
        <property type="protein sequence ID" value="ABB32507"/>
        <property type="gene ID" value="Gmet_2282"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2282"/>
    <dbReference type="eggNOG" id="ENOG5032VP3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126404_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="185" mass="20574" checksum="973C70FFDD02A8B3" modified="2005-11-22" version="1">MTESQSHSVRNGVIATVLGGLILSAIPYARGLLLSLIAWVWSGAVWARKTITLSYPTPGWLLLLIGLFALYGAVCTLFALRPKKEPLHKKYTEDIIYGAKWRWSWVGSNVSNLWCYCPTCDATLVYDDSSCRSRYEPSKTDFICERCNGKVVTTIQGGNKSYAVGAAERELLRKVRTGEYVAAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TJ6</accession>
    <name>Q39TJ6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2201</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365957.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2201"/>
    <dbReference type="EnsemblBacteria" id="ABB32428">
        <property type="protein sequence ID" value="ABB32428"/>
        <property type="gene ID" value="Gmet_2201"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2201"/>
    <dbReference type="eggNOG" id="COG1001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027935_0_0_7"/>
    <dbReference type="OMA" id="MVTACAY"/>
    <dbReference type="OrthoDB" id="751534at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="300"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="6">
        <location>
            <begin position="414"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="594" mass="63696" checksum="485405C0BC35EC1D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TK7</accession>
    <name>Q39TK7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2189</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365946.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32417">
        <property type="protein sequence ID" value="ABB32417"/>
        <property type="gene ID" value="Gmet_2189"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2189"/>
    <dbReference type="eggNOG" id="COG3339">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139031_0_0_7"/>
    <dbReference type="OMA" id="PRVPWYA"/>
    <dbReference type="OrthoDB" id="1236205at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010652">
        <property type="entry name" value="DUF1232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06803">
        <property type="entry name" value="DUF1232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1232" evidence="6">
        <location>
            <begin position="37"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="126" mass="14126" checksum="AB2D1BA930E00306" modified="2005-11-22" version="1">MTTTRLISNARQWARTIKRDVHAVWLAARDPHTPWFAKALALVVAAYAVSPIDLIPDFIPVLGYLDDLVIVPLGILLVVRLIPYEVMAEHREAASKATERPVSRLAAATVITVWIICSLFFARMFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TR1</accession>
    <name>Q39TR1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxybenzoyl-CoA reductase flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcmR</name>
        <name evidence="3" type="ordered locus">Gmet_2134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513071.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2134"/>
    <dbReference type="EnsemblBacteria" id="ABB32363">
        <property type="protein sequence ID" value="ABB32363"/>
        <property type="gene ID" value="Gmet_2134"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2134"/>
    <dbReference type="eggNOG" id="COG1319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058050_0_1_7"/>
    <dbReference type="OMA" id="MVEINFD"/>
    <dbReference type="OrthoDB" id="1017413at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005107">
        <property type="entry name" value="CO_DH_flav_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036683">
        <property type="entry name" value="CO_DH_flav_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002346">
        <property type="entry name" value="Mopterin_DH_FAD-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03450">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00941">
        <property type="entry name" value="FAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01092">
        <property type="entry name" value="CO_deh_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55447">
        <property type="entry name" value="SSF55447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="289" mass="30946" checksum="1A69557583F24181" modified="2005-11-22" version="1">MYMPDFEYHTPETLTEACALLDELGEQATVLAGGTDVLHKMKVGKLAPGHLVSLKNLDDLRTISHEPGRGIVMGALTSHNAIYTSRLLQKRYLSLPMAAHTMASNQICNMGTVGGNIVNGVPSADLPPILIALNASIRLVSSKGERTMPLEDFFHGSAETVIAPGELLADITIPDQPTTGSTYMKFGLRRSGALAVVGVAVSVTVKGDILEDVRIVLASAAPTVMRARKAEDRLRGKKISDELLAEAGEEAAAESRPRDSIRGSAEYRRNLVGVLTKRALRKAIDEGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TX3</accession>
    <name>Q39TX3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2072</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514031.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2072"/>
    <dbReference type="EnsemblBacteria" id="ABB32301">
        <property type="protein sequence ID" value="ABB32301"/>
        <property type="gene ID" value="Gmet_2072"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2072"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_7"/>
    <dbReference type="OMA" id="FYDYSES"/>
    <dbReference type="OrthoDB" id="862072at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044248">
        <property type="term" value="P:cellular catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="185"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="281" mass="30027" checksum="FE801DB4CAE5D5FB" modified="2005-11-22" version="1">MVSKIGVLGAGQMGSGIAHVLAQQGIEVVLFDIAEAQLAKAVTGIEKNLERQAKKGQLESAAISAIVGRIRTTQAMEDLAECDMAIEAVTEKEALKLEIFRKLDGIVKAGAILASNTSSIPITRIAAVTGRPDKVIGMHFMNPVPVMQLVEVIRGLTTSDETFAATTALVAKLGKETAVSADYPGFIVNRILIPMINEAAFALFEGIATVEDIDKGMKLGTNQPMGPLTLADFIGLDTCLAIMNVLHEGFKDSKYRPCPLLVKMVEAGYLGRKTGRGFYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U01</accession>
    <name>Q39U01_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32273">
        <property type="protein sequence ID" value="ABB32273"/>
        <property type="gene ID" value="Gmet_2044"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2044"/>
    <dbReference type="HOGENOM" id="CLU_751762_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="368" mass="41501" checksum="44F5A39A18D89DCA" modified="2005-11-22" version="1">MYDGSGNESHIPLPDRIDLNDRANTEYLLASPTDLWIWSGVLGQAALRHYRLLTNGRSRLPDKAVRVSITKVGDEETRPGALLKLASGGIIAVWHQFRYHLDRRLDMGFAYVNPKGGITTNYPISAPGREGTPVATRWAMAQHPADGSIWAFFKRDSYHEISALHLTETAKGIKLDWVKTDFIGRNDGIHEPEGEYPYLTAVADSGNNSIALAYQNKRSEILYATDGDGNLMNGSCGQSLSQRMEPYFFAKRSLVSIVRITADGRKAFQDFPGLVERTQEFGLSVADRLWVLYRRIDCETSNYEMLQRQGEVMLRYNDGAWSEPLILGKLDVEKEYYGASLFSSPYQPHFLMRLNDGKLHLFEAKSSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UE5</accession>
    <name>Q39UE5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511944.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1900"/>
    <dbReference type="EnsemblBacteria" id="ABB32129">
        <property type="protein sequence ID" value="ABB32129"/>
        <property type="gene ID" value="Gmet_1900"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1900"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_4_7"/>
    <dbReference type="OMA" id="MRYLFTH"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="57"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="252" mass="27033" checksum="F48DC38C082C84FD" modified="2005-11-22" version="1">MAPKSAQRVLPLVSAAAFIAMWQVVARFYPPEQFPAPTDVVKALVELSADGVLWGHIGVSLARFGSAYLLALVTAVPLGLLLGRQPLARCAVDPLIQLLRPISPIAWFPLAVLWFGIGNAPAVFIIFLSVFFPILVSTISAVVKVPVIYLKVAANFGTRPLPTFLRVVVPAAFPGIMVGLHIGVGTGWIHLVAGEMLGAQSGLGFMIIDARNFLRTDWILAGMLVVGLLGLLINRVMRLAELWLGRRWGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UF8</accession>
    <name>Q39UF8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">YbbR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32116.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365884.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1887"/>
    <dbReference type="DNASU" id="3739163"/>
    <dbReference type="EnsemblBacteria" id="ABB32116">
        <property type="protein sequence ID" value="ABB32116"/>
        <property type="gene ID" value="Gmet_1887"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1887"/>
    <dbReference type="eggNOG" id="COG4856">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157869_0_0_7"/>
    <dbReference type="OMA" id="WSCVILE"/>
    <dbReference type="OrthoDB" id="2018101at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32116.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="131" mass="14269" checksum="E5021372B584F1B7" modified="2012-10-31" version="2">MNWNNFSTNWDLKLLSLILAVIVWGGVSGGRTAELELTVPLELRNLPPGFSVASAVPTEASVTVAGPKILLLKLRSERIIIPLDARGVGEGTTLFTGLERRLGLPREATITRLFPATVEVRLIRSKTVQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UJ2</accession>
    <name>Q39UJ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Periplasmic carboxy-terminal processing protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ctpA-2</name>
        <name evidence="7" type="ordered locus">Gmet_1853</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511993.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1853"/>
    <dbReference type="MEROPS" id="S41.004"/>
    <dbReference type="EnsemblBacteria" id="ABB32082">
        <property type="protein sequence ID" value="ABB32082"/>
        <property type="gene ID" value="Gmet_1853"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1853"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_1_1_7"/>
    <dbReference type="OMA" id="DPHSSYY"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223524" evidence="5">
        <location>
            <begin position="29"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="90"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="374"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="443" mass="48488" checksum="7A7F5287C799627B" modified="2005-11-22" version="1">MFGTRKGKKIALLAVVLFAMLAGGGFVAQKHCAAQGGNDYESIELFTDVLAIVKKSYVEEVDTKKLIYGAINGMLASLDPHSSFMPPDMYKEMKIDTKGSFGGLGIEITIKDGILTVISPIEDTPAFRAGIKAGDQILKIDDRFTKDMTIMDAVKRMRGAKGTKVILTIVREGFDKPKDFTLVRDIIQVKSVRFSSLDNGYGYIRIAQFQEKTDDDLVKALATLKEENGGSLKGLVLDLRNDPGGLLDQAVKVADHFVEQGLIVYTEGREKDSRMQFNAHKGGTEPAYPMVVLINGGSASASEIVAGALQDHKRAVVMGTQSFGKGSVQTIIPLSDDSGLRLTTARYYTPNGRSIQAKGITPDIIVERAEIQPTEKKDGHIREKDLENHFESGEKVEGEDKKTEKGKVPAAKSDDQLKGDYQVLRALDLLKGWEILKTMNRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UL2</accession>
    <name>Q39UL2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integration host factor, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ihfB-1</name>
        <name evidence="3" type="ordered locus">Gmet_1833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512013.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1833"/>
    <dbReference type="EnsemblBacteria" id="ABB32062">
        <property type="protein sequence ID" value="ABB32062"/>
        <property type="gene ID" value="Gmet_1833"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1833"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_2_1_7"/>
    <dbReference type="OMA" id="MIVRSEL"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="93" mass="10524" checksum="D24E53B50B5E538F" modified="2005-11-22" version="1">MNKSELIEALAAEKGLTYKKAEEIVSIVFDAMTDAMVRNERIEIRGFGSFVVKDYKAYTGRNPKTGDPIEVKPKKLPFFKVGKELKERVDNGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UM4</accession>
    <name>Q39UM4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">livM</name>
        <name evidence="7" type="ordered locus">Gmet_1821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512024.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1821"/>
    <dbReference type="EnsemblBacteria" id="ABB32050">
        <property type="protein sequence ID" value="ABB32050"/>
        <property type="gene ID" value="Gmet_1821"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1821"/>
    <dbReference type="eggNOG" id="COG4177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031365_2_2_7"/>
    <dbReference type="OMA" id="MIFMRDG"/>
    <dbReference type="OrthoDB" id="1456257at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06581">
        <property type="entry name" value="TM_PBP1_LivM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043428">
        <property type="entry name" value="LivM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30482">
        <property type="entry name" value="PTHR30482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="328" mass="34923" checksum="A6B305ECC4E5A73A" modified="2005-11-22" version="1">MTKLRSFLKHEMVKFILFTILILFLPLAFKGGYLLNVFVFVGIHTLLAVALNLLLGYAGQISLGHAAFFGLGAYASGILTATHGQNPWLAMAVVAAAVGTLAFIIGFPILKLKGHYLAMATLGFGIIVYIAFNEAVELTGGPSGFSGIPNLSLGGFSFDTDFKNYYLIWGMTLVTILLSLNLVNSRIGRGLKAIHDSEVAARVMGVNVRFLKVQIFALSAVISSIAGSLYAHTMTFVSPTSFGFNFSVELVTMVIIGGLGSIYGSFLGAALLTFLPEILRAFQDYDIVVYGLLLIFMTLFMPGGLVRGIPALVGQIVSRAGAGSKADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UM8</accession>
    <name>Q39UM8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidylprolyl cis-trans isomerase, PpiC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1817</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512028.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1817"/>
    <dbReference type="EnsemblBacteria" id="ABB32046">
        <property type="protein sequence ID" value="ABB32046"/>
        <property type="gene ID" value="Gmet_1817"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1817"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090028_6_1_7"/>
    <dbReference type="OMA" id="GPVRTQF"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="92" mass="10109" checksum="254A80A73CDFF2F1" modified="2005-11-22" version="1">MPTATARHILVSTEAECLQLKAEIEAGADFAEIARKNSACPSRMQGGDLGAFVPGQMVKEFDEVVFSGEINKVLGPVRTQFGYHLIEITKRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UN7</accession>
    <name>Q39UN7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512038.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1808"/>
    <dbReference type="EnsemblBacteria" id="ABB32037">
        <property type="protein sequence ID" value="ABB32037"/>
        <property type="gene ID" value="Gmet_1808"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1808"/>
    <dbReference type="HOGENOM" id="CLU_2464634_0_0_7"/>
    <dbReference type="OMA" id="QTWSYEQ"/>
    <dbReference type="OrthoDB" id="2056485at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="86" mass="9913" checksum="1A8B920923D427A1" modified="2005-11-22" version="1">MLKEDVGTEIYKTWSNAQRREEIAKLVQGYRSGLPASIMCKISDSIAGNRKRARKYLHEMLTPEERQIAVDSETGEMMVFVRGYML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UR1</accession>
    <name>Q39UR1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, TerC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513321.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1782"/>
    <dbReference type="EnsemblBacteria" id="ABB32013">
        <property type="protein sequence ID" value="ABB32013"/>
        <property type="gene ID" value="Gmet_1782"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1782"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064910_0_0_7"/>
    <dbReference type="OMA" id="IMFLDIV"/>
    <dbReference type="OrthoDB" id="1917125at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="248" mass="27001" checksum="08BE54C0DF3D62C6" modified="2005-11-22" version="1">MEWLTDPQAWIALATLTALEIVLGIDNIIFISILAGKLPREQQEKARVTGLALAMFTRVGLLFSLTWLMGLTAPLFSVVGREISGRDLILIAGGLFLLAKSTMEIHEKLEGDEGHSSTRAAASFAGTIVQILLLDIVFSLDSIITAIGMANKLAVMVLAVIIAVGFMMFFSGNISAFVHKHPTIKMLALSFLILIGVALIGDGLEMHIPKGYIYFAMAFSVGVEMLNMRMRAKGKPVKLHEPYLEEGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39US4</accession>
    <name>PYRB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate carbamoyltransferase</fullName>
            <ecNumber evidence="1">2.1.3.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartate transcarbamylase</fullName>
            <shortName evidence="1">ATCase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrB</name>
        <name type="ordered locus">Gmet_1769</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>carbamoyl phosphate + L-aspartate = H(+) + N-carbamoyl-L-aspartate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513334.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39US4"/>
    <dbReference type="SMR" id="Q39US4"/>
    <dbReference type="STRING" id="269799.Gmet_1769"/>
    <dbReference type="EnsemblBacteria" id="ABB32000">
        <property type="protein sequence ID" value="ABB32000"/>
        <property type="gene ID" value="Gmet_1769"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1769"/>
    <dbReference type="eggNOG" id="COG0540">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_2_0_7"/>
    <dbReference type="OMA" id="FPTEREY"/>
    <dbReference type="OrthoDB" id="1844275at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00116"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF16">
        <property type="entry name" value="PTHR11405:SF16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000301577" description="Aspartate carbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00001"/>
        </source>
    </evidence>
    <sequence length="311" mass="34141" checksum="9E25353E0C2E21F6" modified="2005-11-22" version="1">MGFKHKDIIALKDLSKDEIELLISTAENMREINSRDIKKVPTLRGKTIINLFYESSTRTRTSFEIAGKRLSADTVNITASTSSATKGETLLDTAKNLEAMKPDIVVMRHAVSGSHYFLAKRLSCSIINAGDGAHEHPSQGLLDMLTIKDRYGRLDGLKVAIVGDITHSRVARSDIAGFTMMGSRVFLAGPPTMMPPGVERLGNVTVCATMKEAIQDADVIIMLRIQQERQGKTLIPNTREYSRYYGLNPENLKWAKPDAMVMHPGPINRGVELSSYVADGANSHVLKQVENGVAVRMAMLYHVSGGTLVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39US5</accession>
    <name>Q39US5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bifunctional protein PyrR</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="4">Pyrimidine operon regulatory protein</fullName>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="4">Uracil phosphoribosyltransferase</fullName>
                <shortName evidence="4">UPRTase</shortName>
                <ecNumber evidence="4">2.4.2.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrR</name>
        <name evidence="6" type="ordered locus">Gmet_1768</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:13017"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513335.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1768"/>
    <dbReference type="EnsemblBacteria" id="ABB31999">
        <property type="protein sequence ID" value="ABB31999"/>
        <property type="gene ID" value="Gmet_1768"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1768"/>
    <dbReference type="eggNOG" id="COG2065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094234_2_1_7"/>
    <dbReference type="OMA" id="PIQPDFC"/>
    <dbReference type="OrthoDB" id="1725260at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01219">
        <property type="entry name" value="PyrR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023050">
        <property type="entry name" value="PyrR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PRPP-binding" evidence="4">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="178" mass="19617" checksum="6B93077A76169C3D" modified="2005-11-22" version="1">MAEEKTTILDGVGVKRALTRIAHEILERNKGVADLVLVGIRTGGVHLARELSSRLEEIEGGKVSVGEVDITLYRDDFKGHAVHLPVGKTDIPFTVEKKKVILVDDVLFTGRTIRAAMDAIMDHGRPGSIQLAVLIDRGHRELPIRADFVGRNVPTSRREKITVQFDADAKPVEVVLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UU8</accession>
    <name>Q39UU8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365865.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1745"/>
    <dbReference type="EnsemblBacteria" id="ABB31976">
        <property type="protein sequence ID" value="ABB31976"/>
        <property type="gene ID" value="Gmet_1745"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1745"/>
    <dbReference type="eggNOG" id="ENOG5032WW2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_384850_0_0_7"/>
    <dbReference type="OMA" id="NENDYHG"/>
    <dbReference type="OrthoDB" id="666200at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223416" evidence="2">
        <location>
            <begin position="25"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="701" mass="78629" checksum="E029CB87CBE366D9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V15</accession>
    <name>Q39V15_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1678</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511386.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1678"/>
    <dbReference type="EnsemblBacteria" id="ABB31909">
        <property type="protein sequence ID" value="ABB31909"/>
        <property type="gene ID" value="Gmet_1678"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1678"/>
    <dbReference type="HOGENOM" id="CLU_1041147_0_0_7"/>
    <dbReference type="OrthoDB" id="2125516at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="267" mass="28534" checksum="CBAED99AED55D480" modified="2005-11-22" version="1">MIKAALVAAMIVGSTLPAWGERLWLVVGASDRTATGIARKAKSLVPTAPNALVVRTGDCGDKRSIFAWVPEIAASPGAARAALSRVRATAKDAYVKRCDARPGTLLALRVTAVDPSVANVPETAVNWEEKDRISTARPLPDGRSIVIVRSFAPAADGPLEGRRESVMLAEPSGKRLVLEENCPSPGPMATQQGRIAFHCARQEAGNHLLHDVVVFGRSGEKLAEIRRCRDPKWAGSQAIECREESVDAEGALKLRTKRIALPPTNSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V22</accession>
    <name>Q39V22_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidoglycan glycosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Gmet_1671</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31902.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1671"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31902">
        <property type="protein sequence ID" value="ABB31902"/>
        <property type="gene ID" value="Gmet_1671"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1671"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_7_7"/>
    <dbReference type="OMA" id="YQLTSMM"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223160" description="Peptidoglycan glycosyltransferase" evidence="12">
        <location>
            <begin position="29"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="14">
        <location>
            <begin position="57"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="13">
        <location>
            <begin position="309"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="630"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB31902.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="660" mass="73067" checksum="DF8DD6319FFC7834" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V95</accession>
    <name>RL32_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmF</name>
        <name type="ordered locus">Gmet_1597</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511468.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V95"/>
    <dbReference type="SMR" id="Q39V95"/>
    <dbReference type="STRING" id="269799.Gmet_1597"/>
    <dbReference type="EnsemblBacteria" id="ABB31829">
        <property type="protein sequence ID" value="ABB31829"/>
        <property type="gene ID" value="Gmet_1597"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1597"/>
    <dbReference type="eggNOG" id="COG0333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129084_1_3_7"/>
    <dbReference type="OMA" id="HRACRHC"/>
    <dbReference type="OrthoDB" id="2092354at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00340">
        <property type="entry name" value="Ribosomal_L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_L32p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044957">
        <property type="entry name" value="Ribosomal_L32p_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35534">
        <property type="entry name" value="PTHR35534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000296471" description="50S ribosomal protein L32">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="60" mass="6628" checksum="F5C2A050DEED561E" modified="2005-11-22" version="1">MAVPKKKTSKSRKNMRRAHDFLTPPAASVCPQCKAPKLPHRACSSCGTYKGKEVIKSEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VA4</accession>
    <name>Q39VA4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphoesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511477.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1588"/>
    <dbReference type="EnsemblBacteria" id="ABB31820">
        <property type="protein sequence ID" value="ABB31820"/>
        <property type="gene ID" value="Gmet_1588"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1588"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039720_0_0_7"/>
    <dbReference type="OMA" id="YTGIMTD"/>
    <dbReference type="OrthoDB" id="1040743at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="2">
        <location>
            <begin position="232"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="316" mass="34363" checksum="26FA9959F055D376" modified="2005-11-22" version="1">MIEGIIEEIRTNGSFLITTHENPDGDAVGSSLALAGYLRRLGKDVTIHFCDPVPDLYAFLPLAEEVTRTVPDRDYDICFVLDVGEFRRAGKQIAECKRIKKFINIDHHLTSDNFGFINYIDPKAAATGILVHRIITGAGDVVGYETALCLYTAIITDTGSFRYSNANPEAFAIAGELVSTGINTWSIAEKLYESQPRERLELLALALSTLTISPRGEYASITVTLDMYNKTGASAELTDGFVNYPRSIRGVEVSVFFREINPGLFKVGFRSKGKIDVSRIAAAFGGGGHHNAAGATMNGSLEGIKATLFSHLESTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VC4</accession>
    <name>Q39VC4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamin biosynthesis thiocarboxylate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">thiF-2</name>
        <name evidence="2" type="ordered locus">Gmet_1568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511497.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1568"/>
    <dbReference type="EnsemblBacteria" id="ABB31800">
        <property type="protein sequence ID" value="ABB31800"/>
        <property type="gene ID" value="Gmet_1568"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1568"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_0_7"/>
    <dbReference type="OMA" id="MIYDALE"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="10"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="269" mass="29035" checksum="852E88B0FDABB9DB" modified="2005-11-22" version="1">MFTEEQIERYSRHIILKEVGGKGQKKLLEGKVMVIGAGGLGAPIALYLAAAGVGTIGIADADVVDLSNLQRQVIHFTPDVGKPKVESAREKMEAINPDVTVRTYQEWISAANIARIIADYDFVIDGTDNFAAKFLINDACVMAGKPYSHGGILQFVGQTMTIKPGESPCYRCIFPAPPPKDAIPTCSQAGVIGVLPGVIGTIQATEAIKYLLGKGALLTGHIMMYDALEMNFRKVKLNRNRKCPVCGDNPTVTELVDELDALNVCDLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VD1</accession>
    <name>Q39VD1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc metalloendopeptidase, M23 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1559</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511506.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1559"/>
    <dbReference type="EnsemblBacteria" id="ABB31793">
        <property type="protein sequence ID" value="ABB31793"/>
        <property type="gene ID" value="Gmet_1559"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1559"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1413363_0_0_7"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M23" evidence="1">
        <location>
            <begin position="47"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="192" mass="20405" checksum="B11566D3890BF451" modified="2005-11-22" version="1">MNRLFIVVVMLLAPLSAWGELELPVSGTVTSGVGWRVDPFGSSRLVYHRGIDIAVPVGTPVRATRGGRVIHAGLHGGHGLAVIVEDDSGGRTLYGHNSELVVRPGERIEPGEVIARSGNSGRSTGPHVHYEVLRDGRETITVARADEELPRPAKADGGLRRQQEQRMDEIVNSILRGIGSAGDGQGGGEPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VG2</accession>
    <name>Q39VG2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Benzoylsuccinyl-CoA thiolase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bbsA</name>
        <name evidence="3" type="ordered locus">Gmet_1528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6 7" key="3">
        <citation type="journal article" date="2022" name="FEBS J." volume="0" first="0" last="0">
            <title>Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism.</title>
            <authorList>
                <person name="Weidenweber S."/>
                <person name="Schuhle K."/>
                <person name="Lippert M.L."/>
                <person name="Mock J."/>
                <person name="Seubert A."/>
                <person name="Demmer U."/>
                <person name="Ermler U."/>
                <person name="Heider J."/>
            </authorList>
            <dbReference type="PubMed" id="35313080"/>
            <dbReference type="DOI" id="10.1111/febs.16443"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS)</scope>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511539.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PXP">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B/E/F=1-146"/>
    </dbReference>
    <dbReference type="PDB" id="7PYT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/C=1-146"/>
    </dbReference>
    <dbReference type="PDB" id="7YXM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A/C=1-146"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1528"/>
    <dbReference type="DNASU" id="3740128"/>
    <dbReference type="EnsemblBacteria" id="ABB31762">
        <property type="protein sequence ID" value="ABB31762"/>
        <property type="gene ID" value="Gmet_1528"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1528"/>
    <dbReference type="eggNOG" id="COG1545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1803037_0_0_7"/>
    <dbReference type="OMA" id="LKGYRCK"/>
    <dbReference type="OrthoDB" id="1756670at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002878">
        <property type="entry name" value="DUF35_OB-fold_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022002">
        <property type="entry name" value="DUF35_Znr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12172">
        <property type="entry name" value="DUF35_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01796">
        <property type="entry name" value="OB_aCoA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5 6 7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF35_N" evidence="2">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="OB_aCoA_assoc" evidence="1">
        <location>
            <begin position="66"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="7PXP"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7PYT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7YXM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16964" checksum="CDFF131B61DF7C04" modified="2005-11-22" version="1">MAKEEVKQKKTKEKEPDITFFHPDILEVPKDGGLPYLKGYRCKKCGQLDFKTEMCTNCWSEEFEMVPLSRRGKVYSFSDIYIGQQGLATPYIFAYVDLPENLRVFAQLEGEVDTYRCDEEVELTLGPIRMNNDNLPIISYKFKKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VG3</accession>
    <name>Q39VG3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein-associated cytochrome b and CCG domain pair iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511540.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1527"/>
    <dbReference type="EnsemblBacteria" id="ABB31761">
        <property type="protein sequence ID" value="ABB31761"/>
        <property type="gene ID" value="Gmet_1527"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1527"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_7"/>
    <dbReference type="OMA" id="TRINQTR"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="281"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="334"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="654" mass="71761" checksum="50C375E357AD1B80" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VK0</accession>
    <name>Q39VK0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Undecaprenyl-diphospho-oligosaccharide flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1490"/>
    <dbReference type="EnsemblBacteria" id="ABB31724">
        <property type="protein sequence ID" value="ABB31724"/>
        <property type="gene ID" value="Gmet_1490"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1490"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043124_0_0_7"/>
    <dbReference type="OMA" id="YIAITFI"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002797">
        <property type="entry name" value="Polysacc_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01943">
        <property type="entry name" value="Polysacc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="326"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="479" mass="52405" checksum="4AD3FD4094D1154B" modified="2005-11-22" version="1">MTGSLISKGMGLLSSILVARMIGKSVFGELGVIQNTIGMLGTFAGFGLGLTATKFIAEYRSADPERAGRIRGLSSAFAWVTGTLASSVLFMFAPWLAKHTLAAPHLADLLRICSLLLFLTSINGAQTGALSGFEAFKTVARINLWSGFANFPLMVGGVYVAGLRGAVWGMIAAAGVNWLLNHLAIRRECRIAGVPYTYKSCWEERGVLWRFSLPSVMGGVLIGPVMWGASALLVNQPNGYAEMGVYNAVMRIKQVPELVLGMVMVPLLPILSEQFGNRSFGQYNKTLRYAFTLSLLVLVPVSLVQIAVPDVTLMPYGKEFNGNRQVVQWLMIHSILVGLFYPFGTIVASMNRMWFGWAYNMMWSVLYFSCSYLLIPESGAKGLCIAFSIAHLVSCIFMTVYVYCKEPDYFQELPFLRFVFITVMAVGICFIAEKTMTPILSGSISAIIIVVYIMLLKNSLTNPSTIRTTVDAETTVSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VL5</accession>
    <name>Q39VL5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RHS repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511593.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1475"/>
    <dbReference type="EnsemblBacteria" id="ABB31709">
        <property type="protein sequence ID" value="ABB31709"/>
        <property type="gene ID" value="Gmet_1475"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1475"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_232692_0_0_7"/>
    <dbReference type="OMA" id="RLTITYN"/>
    <dbReference type="OrthoDB" id="1639867at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045351">
        <property type="entry name" value="DUF6531"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022385">
        <property type="entry name" value="Rhs_assc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031325">
        <property type="entry name" value="RHS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006530">
        <property type="entry name" value="YD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20148">
        <property type="entry name" value="DUF6531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05593">
        <property type="entry name" value="RHS_repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03696">
        <property type="entry name" value="Rhs_assc_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01643">
        <property type="entry name" value="YD_repeat_2x"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223177" evidence="3">
        <location>
            <begin position="26"/>
            <end position="2294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="4">
        <location>
            <begin position="264"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6531" evidence="5">
        <location>
            <begin position="1246"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2271"/>
            <end position="2294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="2294" mass="244934" checksum="566D7BAC90338399" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VL8</accession>
    <name>Q39VL8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein serine/threonine phosphatase, PP2C family, CBS domain pair-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511596.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1472"/>
    <dbReference type="EnsemblBacteria" id="ABB31706">
        <property type="protein sequence ID" value="ABB31706"/>
        <property type="gene ID" value="Gmet_1472"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1472"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_681076_0_0_7"/>
    <dbReference type="OMA" id="GMFEETD"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="177"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="404" mass="44212" checksum="D38EE5975C2C2F9A" modified="2005-11-22" version="1">MTDYCESSVPILRDIAVPNAGVSPNVTVREVVEIFQGDATLLTLPIIDEGEFLGIINRKVLIFKHLGRPFTMELYGKKPIRELLDECPFTMNAGVDVNSALERLIEVDPRLETDSFPVMDGKCCIGIASVAELMMSISRTQAALLQTLNRLTARIRAEVDNARSIQQDLLPLDSARFNNIAISASMTTSTEIGGDFYDYIRLPDSTVCIVMGDVSGHGIQAGMVTTAAKASLHTLIAAGATTPARLLSGMNNAILATARQNLLMTCVVISINQQQRIATIANAGHTFPYLYRTIPTYMERIEVVSGFPLGFERDGGYTELTIPFREGDRLIVYTDGIVEATDSAGRQFGYERFEAVFLEHRELSSDQLKEQLFTDIHSFAASEALDDDVALLIASFDGCAPEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VP6</accession>
    <name>Q39VP6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic polysaccharide biosynthesis/export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31678.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1444"/>
    <dbReference type="EnsemblBacteria" id="ABB31678">
        <property type="protein sequence ID" value="ABB31678"/>
        <property type="gene ID" value="Gmet_1444"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1444"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_717208_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223334" evidence="3">
        <location>
            <begin position="31"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="305"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31678.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="385" mass="39753" checksum="A71FFE3028A20F90" modified="2012-10-31" version="2">MTSRTTAIFGVFVAISASATLMVGDSPVHAASWGLWNDPHGGIVKSVPRPAPAPPPVAPPKAEVPPVPSQDSEKHSDTAALAETAPATSSSAETNPQSSAADSIPSDSAAVPPAVTDATGTVASDNEPGSPVLMATEPAEKAVAAVATENPGTTENRQPVVAESPAKTVADDTTIPVQEQGAIGTSVADQVPATGEMPATKEVPAPNPVVLAGVDQPTSVPPQAGDAYVIGAGDVLDIAVWRDESLTKTVVVLPDGTISFPLIGVVKAGGKTVEQLKDEIRTRLSSYFSDLTLSLEVRQANSMMIFVVGKVNSPGRHPISSPVNVLQALAMAGGVNPFAKKDDIKIFRQDEGKTVIFSFAYSEVSRGNRLEENIVLRRGDLIVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VT4</accession>
    <name>Q39VT4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511661.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1406"/>
    <dbReference type="EnsemblBacteria" id="ABB31640">
        <property type="protein sequence ID" value="ABB31640"/>
        <property type="gene ID" value="Gmet_1406"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1406"/>
    <dbReference type="eggNOG" id="COG1682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060703_3_0_7"/>
    <dbReference type="OMA" id="FVMRTWM"/>
    <dbReference type="OrthoDB" id="1543624at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="30"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="276" mass="32211" checksum="6626E96E136CBC33" modified="2005-11-22" version="1">MGSNTFSPSALQVVLSRISYFRRIWEFRDLFLVFVWREFSVRYKHTLIGAAWAVIQPLSMMLLFTFVFSFVLKMKVSNYPYAVFFYSGLLPWMFFDSAIKYSVPSFTAHYGLITKIYFPREIIPFSCISVAVVDFLISFVVYLFLLLFFDIPLTVNIFYLLPLLFCMILFIASASLILACLNVFYRDVRLAINFIMQLWFFATPVFYSTTQIKGTLKYVLYLNPMTFFIEGFRSCTLYGQPVDLGTLTLFTVLTFTALLITLKLFVRVERLFADVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VX2</accession>
    <name>Q39VX2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein DedA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31602.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1368"/>
    <dbReference type="EnsemblBacteria" id="ABB31602">
        <property type="protein sequence ID" value="ABB31602"/>
        <property type="gene ID" value="Gmet_1368"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1368"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_7_1_7"/>
    <dbReference type="OMA" id="WAKEHWY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31602.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="207" mass="23937" checksum="DFF0AD94AF731D08" modified="2012-10-31" version="2">MNHLLGEYLQQHGYWVLFLWTFLEGEAGLILAGFLAFQGYLTLPAVIVTALGGAFLGDQFYFYLGRWKGPWLLKMFTLVARKFRKALRLIEKYGTFVAFISRYTYGFRIVLPIILGMSSFPASRFLSLNMVSALLWATLFSLAGYFFGKSASLFVEDVSRYEMHLLAALAGLIFCMWLSHFVHAWFRRKPARTRLKRIRDSRKTVDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W04</accession>
    <name>Q39W04_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513171.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1335"/>
    <dbReference type="DNASU" id="3738475"/>
    <dbReference type="EnsemblBacteria" id="ABB31570">
        <property type="protein sequence ID" value="ABB31570"/>
        <property type="gene ID" value="Gmet_1335"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1335"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_1_7"/>
    <dbReference type="OMA" id="PLGAIHN"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Epimerase" evidence="2">
        <location>
            <begin position="11"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="338" mass="36450" checksum="51E3745ED958598E" modified="2005-11-22" version="1">MQPNTYFLHNILVTGATGFVGSFLCSRLLAEGMSVRGTFLVTENPDSLVKGTEQALIEPIGPATFWGHALAGAGTVIHLAARVHVMRERAADPLKEFRFVNTEGTAHLAREAAKAGVKRFVFMGTIGVNGDNSGDAPYIESSPPYPHNPYSVSKYEAEQLLRQISSETGMEVVIIRAPLVYGPGNPGNFLSLLKAVNGDYGFKTLNFGLKVLPLPLASINNKRSLIYVGNLVDALVTCATHPAAVGQTYLVSDGEDVSTPELIRRTAAALGVPARLFPFPVPLMKLAGKLIDKSAAVNRLTGSLTVDSSKIRRELGWQPPFTMEEGLQETAKWFEKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W26</accession>
    <name>Q39W26_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GDP-L-fucose synthase</fullName>
            <ecNumber evidence="2">1.1.1.271</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GDP-4-keto-6-deoxy-D-mannose-3,5-epimerase-4-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">fcl</name>
        <name evidence="4" type="ordered locus">Gmet_1312</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GDP-beta-L-fucose + NADP(+) = GDP-4-dehydro-alpha-D-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:18885"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57273"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.271"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.271" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514785.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1312"/>
    <dbReference type="EnsemblBacteria" id="ABB31548">
        <property type="protein sequence ID" value="ABB31548"/>
        <property type="gene ID" value="Gmet_1312"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1312"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_18_0_7"/>
    <dbReference type="OMA" id="LMACNEF"/>
    <dbReference type="OrthoDB" id="1558163at2"/>
    <dbReference type="UniPathway" id="UPA00128">
        <property type="reaction ID" value="UER00191"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050577">
        <property type="term" value="F:GDP-L-fucose synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042351">
        <property type="term" value="P:'de novo' GDP-L-fucose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05239">
        <property type="entry name" value="GDP_FS_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00956">
        <property type="entry name" value="GDP_fucose_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028614">
        <property type="entry name" value="GDP_fucose/colitose_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="11"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="106"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="164"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="321" mass="36129" checksum="AD7AD762A919EB7F" modified="2005-11-22" version="1">MNKDSRIFVAGSHGLVGSALVRQLRSRGYVNLLLPEKRELDLAHQQAVADFFASQKPDYVFLAAAKVGGIHANNTYPADFIYTNLMIQNNVIHHAWLNGVKRLLFLGSSCIYPKHAPQPMQEEHLLTGPLEPTNEPYAIAKIAGIKMCESYNRQYGTKFVAVMPTNLYGPGDNFHPENSHVLPALIRRFHEAKRQNASSVVVWGSGTPRRELLYVDDMAEGCLHVMDLTDDQLASELLSYPKPCFVNLGTGHDVTIRELAETVRNVVGFSGDLVFDASKPDGTPRKLQDISRMHGLGWRHRVELEEGIRRTYQWYVENYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WK8</accession>
    <name>Q39WK8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phage tail sheath protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the myoviridae tail sheath protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513392.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1128"/>
    <dbReference type="EnsemblBacteria" id="ABB31366">
        <property type="protein sequence ID" value="ABB31366"/>
        <property type="gene ID" value="Gmet_1128"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1128"/>
    <dbReference type="eggNOG" id="COG3497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009303_1_0_7"/>
    <dbReference type="OMA" id="GPRPIEG"/>
    <dbReference type="OrthoDB" id="558210at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035089">
        <property type="entry name" value="Phage_sheath_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020287">
        <property type="entry name" value="Tail_sheath_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04984">
        <property type="entry name" value="Phage_sheath_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17482">
        <property type="entry name" value="Phage_sheath_1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_sheath_1" evidence="2">
        <location>
            <begin position="348"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Phage_sheath_1C" evidence="3">
        <location>
            <begin position="526"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="638" mass="68256" checksum="E63E72767D42ED09" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WM8</accession>
    <name>Q39WM8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flavodoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513762.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1106"/>
    <dbReference type="EnsemblBacteria" id="ABB31346">
        <property type="protein sequence ID" value="ABB31346"/>
        <property type="gene ID" value="Gmet_1106"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1106"/>
    <dbReference type="eggNOG" id="COG0716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_2_0_7"/>
    <dbReference type="OMA" id="CTTATVH"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="156" mass="16664" checksum="59977FFF041F8105" modified="2005-11-22" version="1">MKKVLVTYYSRSGNTEKMARMIADGLATKDVAVDLRKVEEVELDTLPSYDGFIVGSPNYFGTMAWPVKKFVDESVKYFKKLDGKAAAAFTSEGMIGGGGDTVVLDILKAFLIHGCVVQGLTSAGHYGPVAVGAPDGRIADEVGVLVDKFAALVKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WT6</accession>
    <name>Q39WT6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2326 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31288.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513222.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31288">
        <property type="protein sequence ID" value="ABB31288"/>
        <property type="gene ID" value="Gmet_1048"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1048"/>
    <dbReference type="eggNOG" id="COG5293">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033310_0_0_7"/>
    <dbReference type="OMA" id="FPRFVYH"/>
    <dbReference type="OrthoDB" id="1105801at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018760">
        <property type="entry name" value="DUF2326"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10088">
        <property type="entry name" value="DUF2326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2326" evidence="2">
        <location>
            <begin position="424"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="314"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31288.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="566" mass="63897" checksum="63C1277FDB76F02C" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WX1</accession>
    <name>Q39WX1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513181.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1011"/>
    <dbReference type="DNASU" id="3740354"/>
    <dbReference type="EnsemblBacteria" id="ABB31253">
        <property type="protein sequence ID" value="ABB31253"/>
        <property type="gene ID" value="Gmet_1011"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1011"/>
    <dbReference type="eggNOG" id="COG2329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176750_1_0_7"/>
    <dbReference type="OMA" id="INIVEFP"/>
    <dbReference type="OrthoDB" id="2085871at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="96" mass="10895" checksum="C58176B372CF760E" modified="2005-11-22" version="1">MFVVIVNFPPIKAGKETEFQQWFASSNQVFSGFEGFVRRRLLKSVEGETYAAIVEFETRAAFQAMHNSPVHDMYGEQVMPLFDGRPVPAFYEVIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X10</accession>
    <name>Q39X10_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV pilus biogenesis protein PilN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilN</name>
        <name evidence="3" type="ordered locus">Gmet_0972</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514367.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0972"/>
    <dbReference type="EnsemblBacteria" id="ABB31214">
        <property type="protein sequence ID" value="ABB31214"/>
        <property type="gene ID" value="Gmet_0972"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0972"/>
    <dbReference type="eggNOG" id="COG3166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081304_0_0_7"/>
    <dbReference type="OMA" id="DRNLPVH"/>
    <dbReference type="OrthoDB" id="1673053at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="190" mass="20766" checksum="0FB7DC491A728A1E" modified="2005-11-22" version="1">MVKINLLPVRTSKKKETARQQLAILGVSAALVLVAGLGLYVYAQAKIKATKEEISKAENDLQQLKVKIGELENIKKLKDEVTKKLDVLAQLRKGKTGPVRRLATLSDATPDKLWITKYAESGASVSIGGVALDEDLIATFMRNLQRSEDFTNVELVVSEQTEVGGVKAKRFELTCALKAVKNPEPPAPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X67</accession>
    <name>Q39X67_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNH endonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513945.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0915"/>
    <dbReference type="EnsemblBacteria" id="ABB31157">
        <property type="protein sequence ID" value="ABB31157"/>
        <property type="gene ID" value="Gmet_0915"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0915"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136125_0_0_7"/>
    <dbReference type="OMA" id="CHDDEHS"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002711">
        <property type="entry name" value="HNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01844">
        <property type="entry name" value="HNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HNH" evidence="2">
        <location>
            <begin position="50"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="113" mass="12984" checksum="11211BEF1B3BBF0F" modified="2005-11-22" version="1">MGQTFRPRRSGKPAEKSQAELDEMVRRMRGEQSASGSYREQSLKIHGWICAKCGREFDLANLHLLTVHHRDGNHLNNPPDGSNWENLCVWCHDDEHSRGVLGDYLNDGESRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XF7</accession>
    <name>Q39XF7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0825</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514412.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0825"/>
    <dbReference type="EnsemblBacteria" id="ABB31067">
        <property type="protein sequence ID" value="ABB31067"/>
        <property type="gene ID" value="Gmet_0825"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0825"/>
    <dbReference type="eggNOG" id="ENOG5032RFJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896472_0_0_7"/>
    <dbReference type="OMA" id="CFACHEF"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223394" evidence="1">
        <location>
            <begin position="31"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="129"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="305" mass="33565" checksum="41BEEBB1A7BEFFAA" modified="2005-11-22" version="1">MKQGVNRFGRLLVSVALLGWATASAGFAFAAEQTSGATEMGKRSSSPVATVQIQKQPELYAVEPPPLTVTQCGQCHPGVFQDIKKDGGRHAFTCQNCHKSFHSYSPRKNNWDQIMPKCSDCHSPATVAHAQVFTQCAECHSNPHSIKVMPMSQKLLASCATCHAGPPADLKQFPSKHTKLSCADCHTRHGLIPSCNMCHKPHYEGQDFKTCASECHPVHKPKEISYKKDVGTRTCGACHEGVYATWTKTPSRHGKVSCALCHTKHGFIPQCTDCHGLPHSKQLHERFPKCLTCHQDAHNPPVRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XL3</accession>
    <name>Q39XL3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Long-chain acyl-CoA thioesterase, BFIT_BACH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0769</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513514.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0769"/>
    <dbReference type="EnsemblBacteria" id="ABB31011">
        <property type="protein sequence ID" value="ABB31011"/>
        <property type="gene ID" value="Gmet_0769"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0769"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050164_3_2_7"/>
    <dbReference type="OMA" id="KWIDQAG"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016790">
        <property type="term" value="F:thiolester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040170">
        <property type="entry name" value="Cytosol_ACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11049">
        <property type="entry name" value="PTHR11049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="121"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="16498" checksum="FF5FD59D0903A879" modified="2005-11-22" version="1">MNRDWTLIETLLPQDTNSAGNIFGGVLMSLMDKAAAITAWRYARCDMVTAGAEEIAFIRPVHVGEVVKVEARVVCTGRTSIDMAVMVEAEDVFTGQSYEAARGYFTMVALDKGGKPTEVPPWEPRTEEERRRCEASGERRARRRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XM3</accession>
    <name>Q39XM3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phasin superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513504.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0759"/>
    <dbReference type="EnsemblBacteria" id="ABB31001">
        <property type="protein sequence ID" value="ABB31001"/>
        <property type="gene ID" value="Gmet_0759"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0759"/>
    <dbReference type="eggNOG" id="COG3937">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131526_4_2_7"/>
    <dbReference type="OMA" id="EMKSRYK"/>
    <dbReference type="OrthoDB" id="1911664at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008769">
        <property type="entry name" value="PhaF_PhaI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05597">
        <property type="entry name" value="Phasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="106" mass="11889" checksum="E8C9321E1570A926" modified="2005-11-22" version="1">MIELIEKAVLTGLGVVSLSQKKAEELVSDLKEKYKVGEDEGKALVEKLQNMAKDARERVAEMADQEVKRAIERLGLVPREEYDRLVKRVDVLEAKLSTCTEPGTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XN2</accession>
    <name>Q39XN2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fnr-2</name>
        <name evidence="4" type="ordered locus">Gmet_0750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514798.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0750"/>
    <dbReference type="DNASU" id="3739888"/>
    <dbReference type="EnsemblBacteria" id="ABB30992">
        <property type="protein sequence ID" value="ABB30992"/>
        <property type="gene ID" value="Gmet_0750"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0750"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_3_5_7"/>
    <dbReference type="OMA" id="FRDLMMY"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="157"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="238" mass="26544" checksum="137D40599995B3D0" modified="2005-11-22" version="1">MNSKNPRTTIPAPLQSILSAIPLFAPLPPDDINTLSKLIEIQVFPKNRTILHEADTANYMYLVLAGKVRVVQHSNDGTEQVLAIHRKGAFFGEMALLDGRTSPATLIAHEDATVGLIARTAFENQILTNDRMLRQIISVLCSRLRESWFLMKLSRFSSAEQKVRGVLKYLGTQYGVDDSRGKILSIKLTHRTVAGYASVSRETASRILGRFSRAGEIELLASRRMLLKPTLFLNPPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XX0</accession>
    <name>Q39XX0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nitrogenase iron protein</fullName>
            <ecNumber evidence="11">1.18.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nitrogenase Fe protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nitrogenase component II</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Nitrogenase reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">nifH</name>
        <name evidence="14" type="ordered locus">Gmet_0662</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate</text>
            <dbReference type="Rhea" id="RHEA:21448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17997"/>
            <dbReference type="ChEBI" id="CHEBI:18276"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.18.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per dimer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 11">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">The reversible ADP-ribosylation of Arg inactivates the nitrogenase reductase and regulates nitrogenase activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="11">The reversible ADP-ribosylation of Arg-99 inactivates the nitrogenase reductase and regulates nitrogenase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 13">Belongs to the NifH/BchL/ChlL family.</text>
    </comment>
    <dbReference type="EC" id="1.18.6.1" evidence="11"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514270.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0662"/>
    <dbReference type="EnsemblBacteria" id="ABB30904">
        <property type="protein sequence ID" value="ABB30904"/>
        <property type="gene ID" value="Gmet_0662"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0662"/>
    <dbReference type="eggNOG" id="COG1348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059373_0_0_7"/>
    <dbReference type="OMA" id="YVCDYYL"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018697">
        <property type="term" value="F:carbonyl sulfide nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016163">
        <property type="term" value="F:nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00533">
        <property type="entry name" value="NifH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030655">
        <property type="entry name" value="NifH/chlL_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000392">
        <property type="entry name" value="NifH/frxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005977">
        <property type="entry name" value="Nitrogenase_Fe_NifH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42864">
        <property type="entry name" value="PTHR42864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00142">
        <property type="entry name" value="Fer4_NifH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000363">
        <property type="entry name" value="Nitrogenase_iron"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01287">
        <property type="entry name" value="nifH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00746">
        <property type="entry name" value="NIFH_FRXC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00692">
        <property type="entry name" value="NIFH_FRXC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51026">
        <property type="entry name" value="NIFH_FRXC_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 13" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 11 12" id="KW-0013">ADP-ribosylation</keyword>
    <keyword evidence="7 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11 13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="ADP-ribosylarginine; by dinitrogenase reductase ADP-ribosyltransferase" evidence="11 12">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605977-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="289" mass="31503" checksum="481D0F1D85FF9E8D" modified="2005-11-22" version="1">MRQIAIYGKGGIGKSTTTQNTVAGLASLGKKVMIVGCDPKADSTRLILHAKAQATVMDKVRELGTVEDLELDDILKVGYGDVKCVESGGPEPGVGCAGRGVITAINFLEENGAYTDDLDFVFYDVLGDVVCGGFAMPIRENKAEEIYIVCSGEMMAMYAANNIAKGILKYASSGKVRLAGLICNARKTDKEYELIDALAKKLGTQMIHFVPRDNQVQRAELRRMTVIEYSPEHPQANEYRTLAKKILDNKMLVVPTPLEMEELEDLLMEFGIMEAEDESIVGVAEAVAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XZ4</accession>
    <name>RL5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplE</name>
        <name type="ordered locus">Gmet_0638</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514248.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XZ4"/>
    <dbReference type="SMR" id="Q39XZ4"/>
    <dbReference type="STRING" id="269799.Gmet_0638"/>
    <dbReference type="EnsemblBacteria" id="ABB30880">
        <property type="protein sequence ID" value="ABB30880"/>
        <property type="gene ID" value="Gmet_0638"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0638"/>
    <dbReference type="eggNOG" id="COG0094">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061015_2_1_7"/>
    <dbReference type="OMA" id="ERMYAFL"/>
    <dbReference type="OrthoDB" id="1456375at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01333_B">
        <property type="entry name" value="Ribosomal_L5_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_L5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020930">
        <property type="entry name" value="Ribosomal_L5_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_L5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020929">
        <property type="entry name" value="Ribosomal_L5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_L5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_L5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="PTHR11994"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="SSF55282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00358">
        <property type="entry name" value="RIBOSOMAL_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000243005" description="50S ribosomal protein L5">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01333"/>
        </source>
    </evidence>
    <sequence length="179" mass="20140" checksum="43D469D25A70D4E1" modified="2005-11-22" version="1">MARLNELYKNEIVPQLTKDFGYSNIMQVPKIEKIVVNMGLGEAIQNVKILDSAVEELAMITGQKSVITKAKKSIASFKLRQGMPIGCMVTLRREKMFEFLDRLINVALPRVRDFKGVSGKGFDGRGNYSLGIKEQLIFPEIEYDKIDKIKGLNITIVTSARSDEEGKALLKQLGMPFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y54</accession>
    <name>Q39Y54_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NosD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0577</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512275.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0577"/>
    <dbReference type="EnsemblBacteria" id="ABB30820">
        <property type="protein sequence ID" value="ABB30820"/>
        <property type="gene ID" value="Gmet_0577"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0577"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060732_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223449" description="NosD domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="NosD" evidence="3">
        <location>
            <begin position="85"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="262" mass="27053" checksum="FF36B86CA985F98F" modified="2005-11-22" version="1">MKKTLCAIAMLSYCLVMMPAAASAACTAIDKVPFTVRKQGDYCLTRDVSLHDGAVGILVEADQTVIDLGGHRLQGTGGEGSYGIRSEKGVTLRNGTISGFNIGIAGGSGSLIENLWIEKSTRTGILVNGAGSVVRNNIVTDARAAFEAYGIVAMGGKNRILDNRITEMKGASGGRGFGIRVYAAGGNVIEGNQIGNASFIPNTFGIVVSGAESRNNALNANSITNVENGIVYDRGGSGTNRGNRTTGVRNRYVGGTDGGGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y62</accession>
    <name>Q39Y62_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30812.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365687.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0569"/>
    <dbReference type="EnsemblBacteria" id="ABB30812">
        <property type="protein sequence ID" value="ABB30812"/>
        <property type="gene ID" value="Gmet_0569"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0569"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1494180_0_0_7"/>
    <dbReference type="OMA" id="SYPGEAH"/>
    <dbReference type="OrthoDB" id="1570280at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30812.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="179" mass="19043" checksum="9F31F1833B642186" modified="2012-10-31" version="2">MFNDTFDKITWALLAFVIVALAALLAMNHGAGDGKAAGLGKAVEREMAYRARIELIGKLYGPVEDLRKAGKNQEALLKLDELIRSYPGEAHGYILQGEILREMGALDEAVASFEAGVKLNGDYVDARSPLSRRGAIQGLVDEGLRSIGGRAAANPGNRSLAASLAKVNYLKSRLAGGCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y85</accession>
    <name>Q39Y85_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512242.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0546"/>
    <dbReference type="EnsemblBacteria" id="ABB30789">
        <property type="protein sequence ID" value="ABB30789"/>
        <property type="gene ID" value="Gmet_0546"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0546"/>
    <dbReference type="eggNOG" id="ENOG5034C47">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2129878_0_0_7"/>
    <dbReference type="OMA" id="VRSKFVL"/>
    <dbReference type="OrthoDB" id="1894899at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="113" mass="12494" checksum="2DA1FE2037E977D7" modified="2005-11-22" version="1">MDKQEMLNKGQEALTPFETQNIVTFVKNLTLKGAMENPWIIGLFTILVFYAVIKRSKAVLAFLFAVVSIALLIRFTLPAGEGNELSLSSTLPFAFGGLVIGGFLIYFLFIKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y86</accession>
    <name>Q39Y86_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(R)-2-hydroxyacyl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FldB/FldC dehydratase alpha/beta subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512241.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0545"/>
    <dbReference type="EnsemblBacteria" id="ABB30788">
        <property type="protein sequence ID" value="ABB30788"/>
        <property type="gene ID" value="Gmet_0545"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0545"/>
    <dbReference type="eggNOG" id="COG1775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_833421_0_0_7"/>
    <dbReference type="OMA" id="QGDCSNT"/>
    <dbReference type="OrthoDB" id="1815612at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010327">
        <property type="entry name" value="FldB/FldC_alpha/beta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06050">
        <property type="entry name" value="HGD-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="325" mass="37641" checksum="7557DA13684FF847" modified="2005-11-22" version="1">MHRVGFTTTIPLEVILAAEKVPVDLNNVFITSPRSHQLIEEAEVDGFPRSTCSWIKGMYAAILEKGIKELIAVTEGDCSNTRALMEVLSLKGVETVPFAYPHDRQPESIRFEIEKLMRHFGVGWDAVNLSRERLGRIRRKVREIDRLTWEENRVTGAENHYYQVCTSDMNSDPDRFEADVDAFLAEAKNRTPFKDTLRLAYIGVPPIFDDLYQFTESLGARVVFNETQRQFAMPYDTQDMVEQYHVYTYPYDIFHRLSDILLELERRKVDAVIHYVQSFCFRQIEDMIVRQKVPLPILTLEGDKPTPLDARTKIRIEGFLEMLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YC4</accession>
    <name>Q39YC4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Stress-responsive alpha/beta-barrel domain protein, Dabb family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30750.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512203.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30750">
        <property type="protein sequence ID" value="ABB30750"/>
        <property type="gene ID" value="Gmet_0507"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0507"/>
    <dbReference type="eggNOG" id="ENOG5032YE5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080664_3_1_7"/>
    <dbReference type="OMA" id="ARHQVDY"/>
    <dbReference type="OrthoDB" id="1584631at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30750.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="97" mass="10921" checksum="AA3E65F92FFA7BFC" modified="2012-10-31" version="2">MVTHIVFFKLHDPTPANVTATREKLESMRGEIPLLRHLEVGVDVIRSERSYDLALVTKFDSMEDLQAYQVHPYHAGEVIPHMKAVSSSVVAVDYESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YE8</accession>
    <name>Q39YE8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt-precorrin-4 C11-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cbiF</name>
        <name evidence="7" type="ordered locus">Gmet_0483</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513852.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0483"/>
    <dbReference type="EnsemblBacteria" id="ABB30726">
        <property type="protein sequence ID" value="ABB30726"/>
        <property type="gene ID" value="Gmet_0483"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0483"/>
    <dbReference type="eggNOG" id="COG2875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_7_1_7"/>
    <dbReference type="OMA" id="WSAMGEQ"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046026">
        <property type="term" value="F:precorrin-4 C11-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11641">
        <property type="entry name" value="Precorrin-4_C11-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006362">
        <property type="entry name" value="Cbl_synth_CobM/CibF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01465">
        <property type="entry name" value="cobM_cbiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="258" mass="27430" checksum="3765EC6F28A38BDD" modified="2005-11-22" version="1">MTIVHFIGAGPGDAELITVKGARLLREADVVVYAGSLVDRELVRTYAPDAEVCDSAAMTLEETTAVLAQAVADGKRAVRLHTGDPSIYGAIQEQMAELDRLGIAYAVVPGVTSAFAAAATLRQELTLPEVSQTVVITRLAGRTPVPEREKLTEIARIGATLVIYLSISMVEQVVAELLQGAYTPATPVAVVSRASWPDEHVVEGTLADIAGKVRDAGIGKQAIILVGDVLKARREGLKSKSLLYDKGFSHEFRKGIVT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YJ8</accession>
    <name>FLGH_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellar L-ring protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Basal body L-ring protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">flgH</name>
        <name type="ordered locus">Gmet_0433</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512405.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YJ8"/>
    <dbReference type="SMR" id="Q39YJ8"/>
    <dbReference type="STRING" id="269799.Gmet_0433"/>
    <dbReference type="DNASU" id="3738364"/>
    <dbReference type="EnsemblBacteria" id="ABB30676">
        <property type="protein sequence ID" value="ABB30676"/>
        <property type="gene ID" value="Gmet_0433"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0433"/>
    <dbReference type="eggNOG" id="COG2063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069313_0_2_7"/>
    <dbReference type="OMA" id="ITQQPMT"/>
    <dbReference type="OrthoDB" id="1900876at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009427">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, L ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00415">
        <property type="entry name" value="FlgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000527">
        <property type="entry name" value="Flag_Lring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34933">
        <property type="entry name" value="PTHR34933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02107">
        <property type="entry name" value="FlgH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01008">
        <property type="entry name" value="FLGLRINGFLGH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-0998">Cell outer membrane</keyword>
    <keyword id="KW-0449">Lipoprotein</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0564">Palmitate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000236822" description="Flagellar L-ring protein">
        <location>
            <begin position="16"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="N-palmitoyl cysteine" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="lipid moiety-binding region" description="S-diacylglycerol cysteine" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00415"/>
        </source>
    </evidence>
    <sequence length="226" mass="24275" checksum="A5E05C0DC3915CDC" modified="2005-11-22" version="1" precursor="true">MKRLAVSILCLALAGCAIEKAEVRTPSFDEQLPAPQPSYASGSIWQAASAGIAEDHKARRKGDIITVVIVENASASKQATTDTDRKASISASIPYLMGLEKQKLILGKLTGADLGNLLGASTDSTFGGSGATTRKENLVATMSAKIIDVLPNGNFLIEGRRNVKVNNEDQIIILQGTVRPRDVSPDNTVNSSLIADARITYTGEGVISDRQRPGWLMNFLDYIWPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YM6</accession>
    <name>Q39YM6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division protein FtsL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">ftsL</name>
        <name evidence="8" type="ordered locus">Gmet_0405</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential cell division protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <text evidence="6">Localizes to the division septum where it forms a ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FtsL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512377.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0405"/>
    <dbReference type="EnsemblBacteria" id="ABB30648">
        <property type="protein sequence ID" value="ABB30648"/>
        <property type="gene ID" value="Gmet_0405"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0405"/>
    <dbReference type="eggNOG" id="COG3116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_172456_0_0_7"/>
    <dbReference type="OMA" id="IFHVWSR"/>
    <dbReference type="OrthoDB" id="1899339at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00910">
        <property type="entry name" value="FtsL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011922">
        <property type="entry name" value="Cell_div_FtsL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02209">
        <property type="entry name" value="ftsL_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6 8" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="111" mass="12495" checksum="EF020C811BF37B22" modified="2005-11-22" version="1">MAQARTDFTKVAAPKKLEAMYAQRGEMFPFLLAVMVLLTLVSVFHVWSRVRVIDLNLEIAEANRFLKEAQEEQNRLRLEVASLKTPARIEALAKGDLGMALPTDQQVVVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YR7</accession>
    <name>Q39YR7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512336.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0364"/>
    <dbReference type="EnsemblBacteria" id="ABB30607">
        <property type="protein sequence ID" value="ABB30607"/>
        <property type="gene ID" value="Gmet_0364"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0364"/>
    <dbReference type="HOGENOM" id="CLU_206396_0_0_7"/>
    <dbReference type="OMA" id="MVMAYLA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="59" mass="5837" checksum="06966DDF4236AF23" modified="2005-11-22" version="1">MQLLSLALIAIGGAAMAWGLPAAHRLAKPWDVLAAVAALCGLVAVLVGALLAVVPGFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YW9</accession>
    <name>Q39YW9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Succinate dehydrogenase/fumarate reductase, type E, CCG domain pair subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sdhE</name>
        <name evidence="2" type="ordered locus">Gmet_0310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514022.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0310"/>
    <dbReference type="EnsemblBacteria" id="ABB30555">
        <property type="protein sequence ID" value="ABB30555"/>
        <property type="gene ID" value="Gmet_0310"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0310"/>
    <dbReference type="eggNOG" id="COG2048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052147_1_0_7"/>
    <dbReference type="OMA" id="YMPGASC"/>
    <dbReference type="OrthoDB" id="647535at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="149"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="282" mass="30724" checksum="D6E95B6120E6C292" modified="2005-11-22" version="1">MRYAYFLSCINESMTREVDQSLHLWKKDLDLELVTLENGTCCGGSNLDYVSPDHFIIVNGRNIALAEQLGLDLVTSCSTCLLTLRRAKHLLGTSPEKRELVNAHLADEGLRYEGASDVKHLLWVINEDYGLERLAGKVTAPLWGVRFAPFYGCHILRPSSLLGRDNPAAPSSLDRLVEALGGSLVEYGSKNKCCGFHTLLVAEKQSLAMTGNALEDALRAGADYIVTPCPLCHTALDAYQDRALSGRAAAGNIPVLHLSQMIGLALGYSKEELGIDRHMVAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z32</accession>
    <name>FOLD1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein FolD 1</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="1">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">folD1</name>
        <name type="ordered locus">Gmet_0247</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="1"/>
    <dbReference type="EC" id="3.5.4.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513563.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z32"/>
    <dbReference type="SMR" id="Q39Z32"/>
    <dbReference type="STRING" id="269799.Gmet_0247"/>
    <dbReference type="EnsemblBacteria" id="ABB30492">
        <property type="protein sequence ID" value="ABB30492"/>
        <property type="gene ID" value="Gmet_0247"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0247"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_7"/>
    <dbReference type="OMA" id="CKVITAE"/>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000268358" description="Bifunctional protein FolD 1">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <sequence length="290" mass="31744" checksum="2D245E593E767DE7" modified="2005-11-22" version="1">MKLLDGKKCAESLVADIARKVAGYEESGLRKPHMTVILVGEHAPSESYVKSKIKSCGNAGFEGTLLRFPDTITEAELLEKIRGINADPTTDGLIVQLPLPRHINQQHIINAIAPEKDIDGFHPTNFGRMTLGQKAFRPATAYGICKLLQFYEIPVWGKHCVVIGRSNIVGKPISIMLSNDFDIGNATVTLTHIETPRELLLDETRRADIVIVAVGIPGFVTEDMVKEGVVVIDVGINRLEDGKIVGDVDFENVKKKCSWITPVPGGVGRMTVAALMINTLMAYQNNFDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z43</accession>
    <name>Q39Z43_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513552.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0236"/>
    <dbReference type="EnsemblBacteria" id="ABB30481">
        <property type="protein sequence ID" value="ABB30481"/>
        <property type="gene ID" value="Gmet_0236"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0236"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114442_0_0_7"/>
    <dbReference type="OMA" id="HKYDTLA"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="17254" checksum="38190A9FE2D21B33" modified="2005-11-22" version="1">MTKEQLLNQITAALDADLAVLATAARFAHEAATHEECIPDNKYDTTALEASYVAQGQANRAQEIRMALESYRVLALREFDDETPIRLTALVILEDEDGEARRVFLGPEAGGLKIADGEGEIVVITPQSPLGRVLLGKVVGDQLQAGMGGTRKTFTVVEVC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z67</accession>
    <name>DAPA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-tetrahydrodipicolinate synthase</fullName>
            <shortName evidence="1">HTPA synthase</shortName>
            <ecNumber evidence="1">4.3.3.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapA</name>
        <name type="ordered locus">Gmet_0211</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-aspartate 4-semialdehyde + pyruvate = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:34171"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="4.3.3.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512800.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z67"/>
    <dbReference type="SMR" id="Q39Z67"/>
    <dbReference type="STRING" id="269799.Gmet_0211"/>
    <dbReference type="PRIDE" id="Q39Z67"/>
    <dbReference type="EnsemblBacteria" id="ABB30457">
        <property type="protein sequence ID" value="ABB30457"/>
        <property type="gene ID" value="Gmet_0211"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0211"/>
    <dbReference type="eggNOG" id="COG0329">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049343_7_1_7"/>
    <dbReference type="OMA" id="GMDACVP"/>
    <dbReference type="OrthoDB" id="1438588at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00017"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00950">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00418">
        <property type="entry name" value="DapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005263">
        <property type="entry name" value="DapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020625">
        <property type="entry name" value="Schiff_base-form_aldolases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020624">
        <property type="entry name" value="Schiff_base-form_aldolases_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="PTHR12128"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00674">
        <property type="entry name" value="dapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00665">
        <property type="entry name" value="DHDPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00666">
        <property type="entry name" value="DHDPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <feature type="chain" id="PRO_1000050190" description="4-hydroxy-tetrahydrodipicolinate synthase">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="160"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="site" description="Part of a proton relay during catalysis" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="290" mass="31125" checksum="162AF7183711BB85" modified="2005-11-22" version="1">MFKGSIVAIVTPFNNGQVDFEKLRELVEFQISNGTDAIVPCGTTGEASTLDYDEHMDVVKTVIEQVNKRVPVIAGTGSNSTAEAIELSQKAKEVGADGVLLVTPYYNKPTQEGLVRHYTAIADAVAIPQILYNVPGRTGVNMLPETVARLAPHKNIVAIKEATGSLQQASEILALCGDKIDVLCGDDFITFPMMACGAKGVISVLANIMPKTVAELTDAFYAGDMEKARQLHLQTLKIGNAMFIESNPIPVKTALGLMGKCSDEVRLPLCPMGAANKEKLAAIMKEYELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZC3</accession>
    <name>Q39ZC3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH dehydrogenase I, E subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nuoE-2</name>
        <name evidence="8" type="ordered locus">Gmet_0154</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512741.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0154"/>
    <dbReference type="EnsemblBacteria" id="ABB30401">
        <property type="protein sequence ID" value="ABB30401"/>
        <property type="gene ID" value="Gmet_0154"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0154"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_0_7"/>
    <dbReference type="OMA" id="HIIRYCD"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="173" mass="18627" checksum="DDF4745FB4E1332E" modified="2005-11-22" version="1">MLTNRLKSDLQARIAHAVTNREAAVDVIKELQRHYGWLTDEAVAEAAGLLGLTPLQVEELATFYEMIYRRPVGKRVVHVCDSISCWAMGGESLMAHLAAKLGVEPGGTTADGMFTLLPCCCLGNCGEAPTLMIGDTLYGRVTPERGEEILSNARETAATVPEGPGTPQEEENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZH0</accession>
    <name>Q39ZH0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0105</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514110.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0105"/>
    <dbReference type="EnsemblBacteria" id="ABB30354">
        <property type="protein sequence ID" value="ABB30354"/>
        <property type="gene ID" value="Gmet_0105"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0105"/>
    <dbReference type="eggNOG" id="ENOG5032UMB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143367_0_0_7"/>
    <dbReference type="OMA" id="ISCAGAM"/>
    <dbReference type="OrthoDB" id="1933314at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="154" mass="16482" checksum="648FF994F4A0E328" modified="2005-11-22" version="1">MRDFCDADRKKKSGRITLPENPSNLSEEVLAQLESAVKAAVKDGYVSCPAGWKVAGNVGVSRLDVGAMIDKLGIRVTDCQLACFAVSKTSHLGSATEPVSEDVSSRVEDLEEKGALTCANVFALANELNVKPMSVANAANSKRYKIRQCQLGCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZH9</accession>
    <name>Q39ZH9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase, M48 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_0096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0096"/>
    <dbReference type="DNASU" id="3739422"/>
    <dbReference type="EnsemblBacteria" id="ABB30345">
        <property type="protein sequence ID" value="ABB30345"/>
        <property type="gene ID" value="Gmet_0096"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0096"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_0_1_7"/>
    <dbReference type="OMA" id="EMGHHAY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="9">
        <location>
            <begin position="183"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="348" mass="38062" checksum="04B196F5628112D5" modified="2005-11-22" version="1">MMTAPGIYYDGRTSARRTVRLTLEGNRLLVAGEGVETSAELSRLAISSPLSTARRSVRFPSGALCEVSDTRFVDELMRRQGKGRASAAIHRWERSLPLALVALVATVAVVWGFVAFGIPALADKVARAVPPVTEVSLGRESLAMLDKLVFTPSRLPDARRRDIAAQFSRMGRDLPFAAGYRLEFRRSDQLGANALALPSGIIVVTDRLVEIAQSDDELIGVLAHEMGHVRHRHALRHVLQNSATGLIIAAITGDITSITSLAATLPTVLVDASYSRSFETEADDAAVAYLKRRGIPLKSYAAMLGRLEAEHRKKQEEKGKKEKKSLGDYFSTHPVTEERIKRVLEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZN9</accession>
    <name>Q39ZN9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase, HDOD domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0035</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513802.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0035"/>
    <dbReference type="EnsemblBacteria" id="ABB30285">
        <property type="protein sequence ID" value="ABB30285"/>
        <property type="gene ID" value="Gmet_0035"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0035"/>
    <dbReference type="eggNOG" id="COG1639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048246_4_0_7"/>
    <dbReference type="OMA" id="VHHNQIA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="298" mass="33378" checksum="5C2E5AF834812A30" modified="2005-11-22" version="1">MNVDNRIARAEELLATIPELPTVPTVIVSIVQKLHDPEVDIQEILDLLLMDQVLTIRLLRLANSPYYSTMKNIVSLKEAILYLGLDHIKEVIYTCSIVDLFREGKGVIDRATLWSHALGVALVSKRIAKKVGYAEPDNAYIAGLLHDIGEVFLNYYLEPMFAQIAQKAKAEGHSFHGVESLLLGTTHNEVGHVIGRRWNVPKFVTDAMLYHHEPTHAPQDDAGLVSIIAVADQFCRWRSIDYGGYEVSEGGETEYAAWCRMAGHFPGIDADAIETILRDLDNAIEDIRLQVESIFLFI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZP6</accession>
    <name>CH10_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Co-chaperonin GroES</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">10 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-10</fullName>
            <shortName evidence="1">Cpn10</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groES</name>
        <name evidence="1" type="synonym">groS</name>
        <name type="ordered locus">Gmet_0028</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GroES chaperonin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513794.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZP6"/>
    <dbReference type="SMR" id="Q39ZP6"/>
    <dbReference type="STRING" id="269799.Gmet_0028"/>
    <dbReference type="EnsemblBacteria" id="ABB30278">
        <property type="protein sequence ID" value="ABB30278"/>
        <property type="gene ID" value="Gmet_0028"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0028"/>
    <dbReference type="eggNOG" id="COG0234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132825_2_0_7"/>
    <dbReference type="OMA" id="EVKYSGE"/>
    <dbReference type="OrthoDB" id="1965002at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="PTHR10772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000025265" description="Co-chaperonin GroES">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00580"/>
        </source>
    </evidence>
    <sequence length="95" mass="10535" checksum="36E9CE75D8B35314" modified="2005-11-22" version="1">MKLRPLQDRILVKRIEEEQVTAGGIFIPDTAKEKPQRGEIVAVGNGKKTEDGKVIPIDLKVGDKVLFGKYAGTDIKVEGEDFLIMREDDILGVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEN0</accession>
    <name>J9JEN0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heptapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3659"/>
    <dbReference type="EnsemblBacteria" id="AFR42816">
        <property type="protein sequence ID" value="AFR42816"/>
        <property type="gene ID" value="Gmet_3659"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3659"/>
    <dbReference type="HOGENOM" id="CLU_3216768_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="44" mass="5247" checksum="887794EF83D49806" modified="2012-10-31" version="1">MFDRELLVADITNIIWDRRRCGLPFRPQGRHTEAHHGVYRVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PS2</accession>
    <name>Q39PS2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription-repair-coupling factor</fullName>
            <shortName evidence="8">TRCF</shortName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">mfd</name>
        <name evidence="11" type="ordered locus">Gmet_3547</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the N-terminal section; belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513703.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3547"/>
    <dbReference type="EnsemblBacteria" id="ABB33752">
        <property type="protein sequence ID" value="ABB33752"/>
        <property type="gene ID" value="Gmet_3547"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3547"/>
    <dbReference type="eggNOG" id="COG1197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_1_3_7"/>
    <dbReference type="OMA" id="WAPPCRE"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000716">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00969">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036101">
        <property type="entry name" value="CarD-like/TRCF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003711">
        <property type="entry name" value="CarD-like/TRCF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004576">
        <property type="entry name" value="Mfd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037235">
        <property type="entry name" value="TRCF-like_C_D7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005118">
        <property type="entry name" value="TRCF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02559">
        <property type="entry name" value="CarD_CdnL_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03461">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01058">
        <property type="entry name" value="CarD_TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00982">
        <property type="entry name" value="TRCF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141259">
        <property type="entry name" value="SSF141259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143517">
        <property type="entry name" value="SSF143517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00580">
        <property type="entry name" value="mfd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="635"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="817"/>
            <end position="971"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1158" mass="130003" checksum="6D8F95A57770C9CA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q12</accession>
    <name>Q39Q12_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulf_transp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_3453</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0394 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513904.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3453"/>
    <dbReference type="TCDB" id="9.B.102.1.5">
        <property type="family name" value="the yede/yeee (yede/yeee) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33662">
        <property type="protein sequence ID" value="ABB33662"/>
        <property type="gene ID" value="Gmet_3453"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3453"/>
    <dbReference type="eggNOG" id="COG2391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050656_1_1_7"/>
    <dbReference type="OMA" id="THFCTMG"/>
    <dbReference type="OrthoDB" id="1899767at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007272">
        <property type="entry name" value="Sulf_transp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04143">
        <property type="entry name" value="Sulf_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Sulf_transp" evidence="8">
        <location>
            <begin position="26"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="371" mass="39010" checksum="91DD621FA6224D89" modified="2005-11-22" version="1">MFVSPTVIVTAIGLMLGLIAGFVMHRADFCIAGMFRDLFLFRSTARLRALVLYLAVAMVLFEGARLLGLLPLYPFPLLGPASLAGTLGGVLFGIGMVLAGGCVVGTLYRLGAGNRPSLVAFIGLIIGSALYAEFHPFWKSLLTATTLFSGSITIPQYFSLSPTPLIAVAVAILGGLVTFWCRHGQLSRRLYAKGALQLWQAALVLAGVSLASYLLIGMPLGITNAYAKIGAMGEQLVFPDHVADLGFFASQPLSCRNPLTGMMLTGGPGPALDGIALIQFPLIAGIILGSTVSALSLGEFTLGHPAPWRQYLSAAVGGILMGLASRMAPACNVWHFLGGLPILAFSSIFFLAGILPGAWLGACILTRWVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q74</accession>
    <name>Q39Q74_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512614.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3388"/>
    <dbReference type="EnsemblBacteria" id="ABB33600">
        <property type="protein sequence ID" value="ABB33600"/>
        <property type="gene ID" value="Gmet_3388"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3388"/>
    <dbReference type="eggNOG" id="ENOG502ZGTS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1155127_0_0_7"/>
    <dbReference type="OMA" id="GYNSFEF"/>
    <dbReference type="OrthoDB" id="2027084at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="258" mass="26130" checksum="E0BD2FC81CCD1281" modified="2005-11-22" version="1">MKCPKCGYNSFEFLDTCKKCKTDLSGFKQTHGIHSPMTSLAAAAAAPAVAAATVAAAVAAPPAAADENFTWDEPAATATPVPPSIKQGDDIFPSMDLDFATPPPAAPASPPPVSFDLEPTSAAAPPVPPTAQEADLPDFSFDEPAADASATPPSLFGSAPADDDGFASLLETGDSSEETAAAAIPDATPELESAWETPANVFGGFGEGGNEAPPAPQEAGGLDLESFNPSPPTKGPQVELDGFSPAEFDSLFGEPDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QE3</accession>
    <name>Q39QE3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512542.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3318"/>
    <dbReference type="EnsemblBacteria" id="ABB33531">
        <property type="protein sequence ID" value="ABB33531"/>
        <property type="gene ID" value="Gmet_3318"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3318"/>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1709142_0_0_7"/>
    <dbReference type="OMA" id="YLVFRDC"/>
    <dbReference type="OrthoDB" id="1373632at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="170" mass="18901" checksum="2EA4DB85CC336352" modified="2005-11-22" version="1">MSDLMTTRAALQETMTFLGAIASGIEEAIGESANSITYLAGKRLGMQLSANIRKTDDVEEALEAVHQVLLDNNCLWHFEPFKAHDRPALVQTTDSGDEDLQLVFRDCMIRQSLFRFGHHQKGSLCTMMFGFFSGALLNVMGVDSTLEILHAGENACLKRLVIHRKKGEDQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QK2</accession>
    <name>HISZ_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisZ</name>
        <name type="ordered locus">Gmet_3259</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heteromultimer composed of HisG and HisZ subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>This function is generally fulfilled by the C-terminal part of HisG, which is missing in some bacteria such as this one.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366168.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QK2"/>
    <dbReference type="SMR" id="Q39QK2"/>
    <dbReference type="STRING" id="269799.Gmet_3259"/>
    <dbReference type="DNASU" id="3741278"/>
    <dbReference type="EnsemblBacteria" id="ABB33472">
        <property type="protein sequence ID" value="ABB33472"/>
        <property type="gene ID" value="Gmet_3259"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3259"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_0_2_7"/>
    <dbReference type="OMA" id="ELVMPPM"/>
    <dbReference type="OrthoDB" id="1236894at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00125">
        <property type="entry name" value="HisZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004517">
        <property type="entry name" value="HisZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00443">
        <property type="entry name" value="hisZ_biosyn_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000242836" description="ATP phosphoribosyltransferase regulatory subunit">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00125"/>
        </source>
    </evidence>
    <sequence length="434" mass="48054" checksum="CA087E68A8566D74" modified="2005-11-22" version="1">MTNPAPIEAPLPKGVTDFLPEKADKIGYIEGKIRRVFELWGFRRIITPLLEFQDVMAAGLGEDLKERTFRFDDRQTGKLLAIPSDITPQVARIVATRMRGCPLPHRLYYIGRVLRHVELQSGRSRETFQAGVELIGLDSPEADAEMVAMAVEILKGLGFEEFKVDLGHTGFIRGVMAASGLGGDARRRLQEAVGKKDSSAVRAILETEPVADRIKEELAALPRLFGGREVLAEAARVATSDSSRRALDNIAQVLDILDIHGVSDHLTLDLGEIRGLDYHSGLTFEGFVTGIGEAVCSGGRYDNLTQRYGYPAPATGFAFNILALLNALEKRPDVEASKTRDLLIFNLKDDRREALEIAQHLRALGYSTARDIIHRDFNDSLDYARRMNILRMMVIGGDYCAADEAYVVRVADKRGTAVKKADLMRNDFSLNTLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QN5</accession>
    <name>Q39QN5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3226</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512665.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3226"/>
    <dbReference type="EnsemblBacteria" id="ABB33439">
        <property type="protein sequence ID" value="ABB33439"/>
        <property type="gene ID" value="Gmet_3226"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3226"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1407001_0_0_7"/>
    <dbReference type="OMA" id="HIGVAGW"/>
    <dbReference type="OrthoDB" id="1821366at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223163" evidence="3">
        <location>
            <begin position="26"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="177"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="230" mass="24563" checksum="55A1E54DAF2D801D" modified="2005-11-22" version="1">MNGTLRLVASSLVLSLASLSSASGAEYLRYAPEPSDGKPLAGPEEGVLVERITIEKGDTLYGLSRKYSGKGTYFSQILLFNEIANPNLIYAGHKLLVPLPPGHGEETAAPTRRAKPAEKRKGARKHQAVTPASKEAKPVVKLPAATTRPSSPPRASEVPASKAVSPSPATRKGGENEQTLFEKGVSAYKSGQYQQSLDAFDRFLARYPESPLAPDASLYRADALMKMAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QS3</accession>
    <name>Q39QS3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512626.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3188"/>
    <dbReference type="EnsemblBacteria" id="ABB33401">
        <property type="protein sequence ID" value="ABB33401"/>
        <property type="gene ID" value="Gmet_3188"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3188"/>
    <dbReference type="eggNOG" id="ENOG50334XP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147355_0_0_7"/>
    <dbReference type="OMA" id="MRTKATM"/>
    <dbReference type="OrthoDB" id="1813963at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023824">
        <property type="entry name" value="CHP04073_exosortase-affil"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04073">
        <property type="entry name" value="exo_TIGR04073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004222994" evidence="1">
        <location>
            <begin position="23"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="138" mass="15394" checksum="2C9B63F24EA9E1EA" modified="2005-11-22" version="1">MRSFAWFLALTLTLSCSTPLFAQDEPKPEFVVEKMAFKLARGVTNFATAIVELPKQSYLSVRDRGNVGYVIGPLKGVGMTLYRAFIGATEAVFFPVPQPGYYDPMIEPDFVWKGWEPPQRATVEEGDMTMETESGEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QZ2</accession>
    <name>Q39QZ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphoaspartate phosphatase CheX associated with MCPs of classes 40H and 40+24H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheX64H</name>
        <name evidence="3" type="ordered locus">Gmet_3118</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514293.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3118"/>
    <dbReference type="EnsemblBacteria" id="ABB33332">
        <property type="protein sequence ID" value="ABB33332"/>
        <property type="gene ID" value="Gmet_3118"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3118"/>
    <dbReference type="eggNOG" id="COG1406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116290_0_1_7"/>
    <dbReference type="OMA" id="NVEYINP"/>
    <dbReference type="OrthoDB" id="1956590at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038756">
        <property type="entry name" value="CheX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39452">
        <property type="entry name" value="PTHR39452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="55"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="168" mass="18203" checksum="DADA6C08088E9AB2" modified="2005-11-22" version="1">MTLASGVAEATRLTEEQVAGFIIDATKEVFNTMVMMELEDQYPLQEPVTKFRCSVTGMVGLAGTYSGILSIHCPLEFALRITSNMLGMEVDQVGEDVNDALGEIANMLGGYVKMVLSKGGMDLHLSVPTVISGEEYTLNAMADSDCVIIPFVNESQRFLVGLKLQKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R21</accession>
    <name>Q39R21_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TOBE_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514543.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3089"/>
    <dbReference type="EnsemblBacteria" id="ABB33303">
        <property type="protein sequence ID" value="ABB33303"/>
        <property type="gene ID" value="Gmet_3089"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3089"/>
    <dbReference type="eggNOG" id="ENOG50330V5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174550_0_0_7"/>
    <dbReference type="OMA" id="IRCKYEV"/>
    <dbReference type="OrthoDB" id="1906389at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013611">
        <property type="entry name" value="Transp-assoc_OB_typ2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08402">
        <property type="entry name" value="TOBE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223437" description="TOBE_2 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="TOBE_2" evidence="2">
        <location>
            <begin position="20"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="98" mass="10457" checksum="0CD9B554C5ABCC40" modified="2005-11-22" version="1">MRKAIAAAAAVIMLSIGTIAGAAEVKMVGTVQKIEMQGGTATVILKDTKSDKEVKVTVKDDLTLDKFKDKRIVEGDEVRVKFDDGDGVVTIFRKTAGC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R75</accession>
    <name>TRMB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine-N(7)-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">tRNA(m7G46)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trmB</name>
        <name type="ordered locus">Gmet_3034</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33249.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366135.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39R75"/>
    <dbReference type="SMR" id="Q39R75"/>
    <dbReference type="STRING" id="269799.Gmet_3034"/>
    <dbReference type="PRIDE" id="Q39R75"/>
    <dbReference type="EnsemblBacteria" id="ABB33249">
        <property type="protein sequence ID" value="ABB33249"/>
        <property type="gene ID" value="Gmet_3034"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3034"/>
    <dbReference type="eggNOG" id="COG0220">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050910_2_0_7"/>
    <dbReference type="OMA" id="WRGAKTA"/>
    <dbReference type="OrthoDB" id="1025521at2"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01057">
        <property type="entry name" value="tRNA_methyltr_TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="PTHR23417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00091">
        <property type="entry name" value="TIGR00091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000229165" description="tRNA (guanine-N(7)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01057"/>
        </source>
    </evidence>
    <sequence length="211" mass="24163" checksum="9172E0A938036299" modified="2007-05-29" version="2">MQRMIEISSPFFLNPDELSTPADWAAVFGNANPLALEIGCGIGDFIARTAADNPGTNYIAIDFYNKGCDKTCRRLERLAIPNVRVVRDEARKFIVERIPKGSLCAVHINCPDPWPKMRHRKRRLVNREFAAFIREYLAPGGDFYFATDFDDYGIDVAEFMPGVEGYANMLAPDRYRHELEGYHLSKYMMKFMAEGKRIYFVHYRKTAEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R77</accession>
    <name>Q39R77_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4212 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3032</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514346.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3032"/>
    <dbReference type="EnsemblBacteria" id="ABB33247">
        <property type="protein sequence ID" value="ABB33247"/>
        <property type="gene ID" value="Gmet_3032"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3032"/>
    <dbReference type="eggNOG" id="COG4327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2193202_0_0_7"/>
    <dbReference type="OMA" id="LFNLPLH"/>
    <dbReference type="OrthoDB" id="1804830at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019886">
        <property type="entry name" value="Na_symporter_ssu_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13937">
        <property type="entry name" value="DUF4212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03647">
        <property type="entry name" value="Na_symport_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4212" evidence="2">
        <location>
            <begin position="16"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="108" mass="13026" checksum="D85961BEEDC63AC2" modified="2005-11-22" version="1">MEHDREWYDVNIFRPRKGYMTGEVVIILFVLLGWAVANFGVQAILWLLSETPQGEGILTRLTFLSFPWHFWFTAQFLPLWFIILCILFNIYIDRHTEQHSRRKDRSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RF4</accession>
    <name>Q39RF4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protoporphyrinogen IX dehydrogenase [quinone]</fullName>
            <ecNumber evidence="5">1.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Protoporphyrinogen IX dehydrogenase [menaquinone]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protoporphyrinogen IX dehydrogenase [ubiquinone]</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Protoporphyrinogen oxidase</fullName>
            <shortName evidence="5">PPO</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">hemG</name>
        <name evidence="7" type="ordered locus">Gmet_2953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX; under anaerobic conditions uses menaquinone as an electron acceptor, under aerobic conditions uses ubiquinone as an electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3 a menaquinone + protoporphyrinogen IX = 3 a menaquinol + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:27409"/>
            <dbReference type="Rhea" id="RHEA-COMP:9537"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="ChEBI" id="CHEBI:16374"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3 a quinone + protoporphyrinogen IX = 3 a quinol + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:65032"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>3 a ubiquinone + protoporphyrinogen IX = 3 a ubiquinol + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:63936"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="5">Binds 1 FMN non-covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HemG family.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.3" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512888.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2953"/>
    <dbReference type="DNASU" id="3740808"/>
    <dbReference type="EnsemblBacteria" id="ABB33170">
        <property type="protein sequence ID" value="ABB33170"/>
        <property type="gene ID" value="Gmet_2953"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2953"/>
    <dbReference type="eggNOG" id="COG4635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094839_0_1_7"/>
    <dbReference type="OMA" id="IEYTDWE"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070819">
        <property type="term" value="F:menaquinone-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00853">
        <property type="entry name" value="HemG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026816">
        <property type="entry name" value="Flavodoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044264">
        <property type="entry name" value="HemG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12724">
        <property type="entry name" value="Flavodoxin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2 5" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="6">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="175" mass="20268" checksum="F70ED887790ECA36" modified="2005-11-22" version="1">MANILIIYATTDGQTRRISRRLQEVIERQSHHVTVVPIEDAPSLDLTAFDKIVIGASIRYGKHSPLITDFIEKNKSFLESRPNAFFSVNVVARKPEKSKPEHNPYLQKFLNRIEWKPRKLAVFAGKIDYPSYRFFDRLMIRLIMRMTKGPTDPKAVVEFTDWGQVEAFGRVISDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RG8</accession>
    <name>Q39RG8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis sensory transducer, class 40+24H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mcp64H-1</name>
        <name evidence="6" type="ordered locus">Gmet_2938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512874.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2938"/>
    <dbReference type="EnsemblBacteria" id="ABB33156">
        <property type="protein sequence ID" value="ABB33156"/>
        <property type="gene ID" value="Gmet_2938"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2938"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_99_0_7"/>
    <dbReference type="OMA" id="AVENMET"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="67"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="208"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="564" mass="60171" checksum="7F613B8514B44024" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RK3</accession>
    <name>Q39RK3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">N5-carboxyaminoimidazole ribonucleotide mutase</fullName>
            <shortName evidence="3 4">N5-CAIR mutase</shortName>
            <ecNumber evidence="3 4">5.4.99.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">5-(carboxyamino)imidazole ribonucleotide mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">purE</name>
        <name evidence="7" type="ordered locus">Gmet_2903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate</text>
            <dbReference type="Rhea" id="RHEA:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58730"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="EC" id="5.4.99.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the AIR carboxylase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.18" evidence="3 4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512839.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2903"/>
    <dbReference type="EnsemblBacteria" id="ABB33121">
        <property type="protein sequence ID" value="ABB33121"/>
        <property type="gene ID" value="Gmet_2903"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2903"/>
    <dbReference type="eggNOG" id="COG0041">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094982_2_0_7"/>
    <dbReference type="OMA" id="SNSIDGW"/>
    <dbReference type="OrthoDB" id="1701464at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00943"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034023">
        <property type="term" value="F:5-(carboxyamino)imidazole ribonucleotide mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01929">
        <property type="entry name" value="PurE_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033747">
        <property type="entry name" value="PurE_ClassI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024694">
        <property type="entry name" value="PurE_prokaryotes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001338">
        <property type="entry name" value="AIR_carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01162">
        <property type="entry name" value="purE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 3 4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="6">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001338-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="169" mass="16993" checksum="BC9499FCF1FC68D5" modified="2005-11-22" version="1">MGNPQVLIVMGSDSDLSIMEEAAKVLDEFGVAWEMRVASAHRSPKKAAALAAGAAARGVKAIIAGAGMAAHLAGVIAADTVLPVIAVPIPGGALNGVDALYAMVQMPGGIPVATMAIGKAGAKNAGLLAVQIIALGDPALTAELVAHKQAMADEVEAKDNALQERLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RY7</accession>
    <name>Q39RY7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxoglutarate dehydrogenase (succinyl-transferring)</fullName>
            <ecNumber evidence="4">1.2.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">sucA</name>
        <name evidence="8" type="ordered locus">Gmet_2769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511692.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2769"/>
    <dbReference type="EnsemblBacteria" id="ABB32987">
        <property type="protein sequence ID" value="ABB32987"/>
        <property type="gene ID" value="Gmet_2769"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2769"/>
    <dbReference type="eggNOG" id="COG0567">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004709_1_0_7"/>
    <dbReference type="OMA" id="RDSYCRT"/>
    <dbReference type="OrthoDB" id="29166at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="PTHR23152"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Transket_pyr" evidence="7">
        <location>
            <begin position="557"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="896" mass="99062" checksum="4DFD8EB030CB96CD" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S57</accession>
    <name>Q39S57_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2699"/>
    <dbReference type="EnsemblBacteria" id="ABB32917">
        <property type="protein sequence ID" value="ABB32917"/>
        <property type="gene ID" value="Gmet_2699"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2699"/>
    <dbReference type="eggNOG" id="COG2928">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068050_1_1_7"/>
    <dbReference type="OMA" id="PTTGWYT"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007462">
        <property type="entry name" value="COV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31876">
        <property type="entry name" value="PTHR31876"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04367">
        <property type="entry name" value="DUF502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="219" mass="24124" checksum="B841DAFCFB8EA359" modified="2005-11-22" version="1">METVDFAGAGGIFVGNLHCKGLGMEKVINHLKSRFVTGLFVVVPVGVTIFVLKFLFSFADGLLGSYLDRLLIAVTNHDYYFPGLGMITGAVVVYLTGLLAANVMGKRLLRWWDALLARIPLVKSIYTSSKQLTQVFQEGKSSYRRAVFVEWPRKGVRAVGFVTAEVEREGERLVVVYVPTMPNPTSGFALFFREDEVYESGMTVEDAVKFVVSGGVVVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S67</accession>
    <name>Q39S67_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gltA</name>
        <name evidence="6" type="ordered locus">Gmet_2689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511772.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2689"/>
    <dbReference type="EnsemblBacteria" id="ABB32907">
        <property type="protein sequence ID" value="ABB32907"/>
        <property type="gene ID" value="Gmet_2689"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2689"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_7"/>
    <dbReference type="OMA" id="HADHEMN"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="441" mass="49633" checksum="88C43486417097A8" modified="2005-11-22" version="1">MALKETLKQKIEEFRPRTTRLVKEFGKVVIDQVTIDQAIGGARDIRSLVTDISYLDPQEGIRFRGKTIPETFEALPKASGSDYPTVESFWYFLLTGEVPTQAQVDEVVAEWKTRQVVPQYVFDAISALPKESHPMVMLSVGILALQKDSKFAGFYNSGKFNKMTAWEYVYEDASDLVARIPIIAAFIYNLKYRGGKQSAIDPTADCGANFARMIGQCKEYEDVARMYFILHSDHESGNVSAHTTHLVHSALSDPYYAYSAGLNGLAGPLHGLANQEVLDWTIKFQQKYCKDVEPTKELVTKALWDTLNAGQVVPGYGHAVLRKTDPRYMSQREFCLKTPGLKDDPLFKLVAMIFETAPGVLMEHGKAKNPWPNVDAQSGVIQWYYGLREWDFYTVLFGVGRALGCMANITWDRGLGYAIERPKSVTTPMLEKWAEEGGRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S80</accession>
    <name>Q39S80_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FAD-dependent oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511785.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2676"/>
    <dbReference type="EnsemblBacteria" id="ABB32894">
        <property type="protein sequence ID" value="ABB32894"/>
        <property type="gene ID" value="Gmet_2676"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2676"/>
    <dbReference type="eggNOG" id="COG2509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028644_3_0_7"/>
    <dbReference type="OMA" id="SVYSFCM"/>
    <dbReference type="OrthoDB" id="1770293at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028348">
        <property type="entry name" value="FAD-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42842">
        <property type="entry name" value="PTHR42842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038984">
        <property type="entry name" value="FAD_binding_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAO" evidence="1">
        <location>
            <begin position="206"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="533" mass="56993" checksum="879BAE8F9E811474" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SE7</accession>
    <name>Q39SE7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEP motif-containing protein, putative exosortase substrate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511853.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2608"/>
    <dbReference type="EnsemblBacteria" id="ABB32827">
        <property type="protein sequence ID" value="ABB32827"/>
        <property type="gene ID" value="Gmet_2608"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2608"/>
    <dbReference type="eggNOG" id="COG3712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1164089_0_0_7"/>
    <dbReference type="OrthoDB" id="2058368at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223226" evidence="1">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="238" mass="25311" checksum="4321C1562A80256C" modified="2005-11-22" version="1">MKSILCLLAAGLFTALSFASAEAISITADKDAYVQSGTSANTNFGSALVDQVKRQDNSIYTRKSYFGFDLSGLGPYPIASATLDFNFVDSGAGTTLAGTTYQFEVFGLINELFDSWSESTITWNNAPANRTNNGLSNMMVASLGTFSLTGKGLGLHSFTSPELIDFLNSDTNDMATFIIRRNTNQPSNSQNYVHAFASSENTSIAGPTLNVTPVPEPSTLLCVGAGLIGLGLLKRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SI4</accession>
    <name>Q39SI4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase DUF815, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513463.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2571"/>
    <dbReference type="DNASU" id="3738875"/>
    <dbReference type="EnsemblBacteria" id="ABB32790">
        <property type="protein sequence ID" value="ABB32790"/>
        <property type="gene ID" value="Gmet_2571"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2571"/>
    <dbReference type="eggNOG" id="COG2607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039512_0_0_7"/>
    <dbReference type="OMA" id="AIQWSHD"/>
    <dbReference type="OrthoDB" id="1657201at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008533">
        <property type="entry name" value="DUF815"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05673">
        <property type="entry name" value="DUF815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF815" evidence="1">
        <location>
            <begin position="35"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="297" mass="34177" checksum="1876946DD700BFB1" modified="2005-11-22" version="1">MLTMKPEFVAQLERVLSSVEMLLPRAVKPVNWSTCYAANWRRHSFSGFLQAVRVTDTTSLHELLGVEKQKEIMISNTRQFLKGLPANNALLWGSRGTGKSSLVKALLNEYACEGLRVIQVEKEDLIYLSDIFSAVEGEPYRFILLCDDLTFEPGELTYKILKSALDGSVYSPPENVLIYVTSNRRHLLPEYESDNIGWKLVNGELQESEATEEKIALSDRFGLWVPFHVFTQDRYLEAVRLCVEREARTREVDIPWSEQLRLDAIQWSHDKKKRCGRTAYQFSKHWVGKYLLARQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SJ1</accession>
    <name>Q39SJ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase, YcaC-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513470.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2564"/>
    <dbReference type="EnsemblBacteria" id="ABB32783">
        <property type="protein sequence ID" value="ABB32783"/>
        <property type="gene ID" value="Gmet_2564"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2564"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066901_0_1_7"/>
    <dbReference type="OMA" id="LFMLCDV"/>
    <dbReference type="OrthoDB" id="1860541at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="15"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="187" mass="20440" checksum="C821B54AC2FF4301" modified="2005-11-22" version="1">MGIMDTFFLDRNQAVLVVVDVQEKLCAAMNQEVLAQLTKNTGILLEAAKELGIPVVATEQYVKGLGCTVPELRQQFEGAAFEKMAFSCCGDEAFLNRLAELGRKQVIVTGMETHVCVLQTILELRERGYHVHLVKDAVMSRKKGNWKVGVNAAAAAGAAITSTEAALFQLLRVAGTEEFKKLSKLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SX7</accession>
    <name>Q39SX7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyl-accepting chemotaxis sensory transducer, class 34H, PAS and PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mcp34H-8</name>
        <name evidence="9" type="ordered locus">Gmet_2422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512478.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2422"/>
    <dbReference type="EnsemblBacteria" id="ABB32647">
        <property type="protein sequence ID" value="ABB32647"/>
        <property type="gene ID" value="Gmet_2422"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2422"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_0_7"/>
    <dbReference type="OMA" id="NCACGRA"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="211"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="300"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="525"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="702"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="757"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="761"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="943"/>
            <end position="988"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1046" mass="111636" checksum="728DD75456F97EFC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SX9</accession>
    <name>Q39SX9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chemotaxis protein methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cheR34H</name>
        <name evidence="8" type="ordered locus">Gmet_2420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512480.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2420"/>
    <dbReference type="EnsemblBacteria" id="ABB32645">
        <property type="protein sequence ID" value="ABB32645"/>
        <property type="gene ID" value="Gmet_2420"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2420"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_0_0_7"/>
    <dbReference type="OMA" id="FMGHSET"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026024">
        <property type="entry name" value="Chemotaxis_MeTrfase_CheR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000410">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000410-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="289" mass="32897" checksum="08220B419F78C5A4" modified="2005-11-22" version="1">MLNSATDNRLATAAMSDREFSRFAEFIYDQCGIKMPPAKKTMLEARLQKRLRALGLRGFQDYADFIFSREGAGLELVHLIDVVTTNKTDFFREPAHFDYLVGKALPDLAESRGAGFRKGLSLWSAGCSSGEEPYTLAMVLAEFAEQNQGFSYSILATDICTTVLDKAKLAIYEEERVEPVSLPLKRKYLLRGKDGQKGLVRVIPELRGRIRFRRLNFMDDDFGLREPMDIIFCRNVIIYFDKRTQERLLNKFCRHLIPGGYLFMGHSETLSGLDVPLVQVASTIYRKPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SY0</accession>
    <name>Q39SY0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable chemoreceptor glutamine deamidase CheD</fullName>
            <ecNumber evidence="3">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheD</name>
        <name evidence="4" type="synonym">cheD34H</name>
        <name evidence="4" type="ordered locus">Gmet_2419</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CheD family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.44" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512481.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2419"/>
    <dbReference type="EnsemblBacteria" id="ABB32644">
        <property type="protein sequence ID" value="ABB32644"/>
        <property type="gene ID" value="Gmet_2419"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2419"/>
    <dbReference type="eggNOG" id="COG1871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087854_1_0_7"/>
    <dbReference type="OMA" id="RIGGMCH"/>
    <dbReference type="OrthoDB" id="1863047at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01440">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="PTHR35147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="16840" checksum="2837DAC029B9D5EE" modified="2005-11-22" version="1">MTAIAPDLPKVYLKPGELHFAATPAVVTTVLGSCVSVTMFDRLSGTAAICHALLPEGPRSDAFRYVDSSILLMLEMFAAQGVSRQRLEVKVFGGADIIGAGGNRVGVGRRNVEIATLVLAANGLTVAAKDVGGTRGRKLFFVTHTGEVFLKRLRRGGGAE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SY7</accession>
    <name>SYN_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Asparagine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Asparaginyl-tRNA synthetase</fullName>
            <shortName evidence="1">AsnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">asnS</name>
        <name type="ordered locus">Gmet_2412</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + H(+) + L-asparaginyl-tRNA(Asn)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512488.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SY7"/>
    <dbReference type="SMR" id="Q39SY7"/>
    <dbReference type="STRING" id="269799.Gmet_2412"/>
    <dbReference type="EnsemblBacteria" id="ABB32637">
        <property type="protein sequence ID" value="ABB32637"/>
        <property type="gene ID" value="Gmet_2412"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2412"/>
    <dbReference type="eggNOG" id="COG0017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004553_2_0_7"/>
    <dbReference type="OMA" id="DNMDLAE"/>
    <dbReference type="OrthoDB" id="1138123at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000051394" description="Asparagine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00534"/>
        </source>
    </evidence>
    <sequence length="461" mass="51327" checksum="891FEDD44E2844E5" modified="2005-11-22" version="1">MSARIRIRNALAGEGLGNEIMVKGWVRTIRTGKEVAFLALNDGSCFANLQVVAEPGLATFADVCAIGTGAAVAVRGRLVDSPASGQCYELHADEVAVIGLADESYPLQKKRHSFEYLRSIAHLRPRSNTFGAVFRVRSSVAQAVHRFFAERGFLYVHTPIITTSDCEGAGEMFRVTTLDPAAPPLLEGEVDFSRDFFAAQAGLTVSGQLEGELFAQAFSDIYTFGPTFRAENSNTPRHAAEFWMIEPEMAFADLMADAALAEEFFRYLCRHVLDACGEDMAFFNDHIDKGLIARVEQVANSSFAIMEYGEAIERLKKATVTFEYPVEWGLDLQTEHERYLTEQVVGGPVFVINYPKHIKAFYMRVNDDNKTVAAMDLLVPKVGEIIGGSQREERLPVLEGRMAEVGVNPEGLWWYLDSRRWGSTPHAGFGLGFERLIMYLTGMENIRDVIPFPRTPRHAEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T06</accession>
    <name>Q39T06_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="8" type="synonym">ftsH-1</name>
        <name evidence="8" type="ordered locus">Gmet_2393</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514765.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2393"/>
    <dbReference type="EnsemblBacteria" id="ABB32618">
        <property type="protein sequence ID" value="ABB32618"/>
        <property type="gene ID" value="Gmet_2393"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2393"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_0_7"/>
    <dbReference type="OMA" id="RRSNGMP"/>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="207"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="215"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="436"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="619" mass="68038" checksum="6BDDA3EEA82DB787" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T73</accession>
    <name>RPOZ_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit omega</fullName>
            <shortName evidence="1">RNAP omega subunit</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase omega subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit omega</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoZ</name>
        <name type="ordered locus">Gmet_2326</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase subunit omega family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513294.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T73"/>
    <dbReference type="SMR" id="Q39T73"/>
    <dbReference type="STRING" id="269799.Gmet_2326"/>
    <dbReference type="EnsemblBacteria" id="ABB32551">
        <property type="protein sequence ID" value="ABB32551"/>
        <property type="gene ID" value="Gmet_2326"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2326"/>
    <dbReference type="eggNOG" id="COG1758">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125406_5_1_7"/>
    <dbReference type="OMA" id="NVDNRFQ"/>
    <dbReference type="OrthoDB" id="1864134at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00366">
        <property type="entry name" value="RNApol_bact_RpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003716">
        <property type="entry name" value="DNA-dir_RNA_pol_omega"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34476">
        <property type="entry name" value="PTHR34476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="SSF63562"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00690">
        <property type="entry name" value="rpoZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000237462" description="DNA-directed RNA polymerase subunit omega">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00366"/>
        </source>
    </evidence>
    <sequence length="69" mass="7665" checksum="603A11A8A1163782" modified="2005-11-22" version="1">MARVTVEDCLEKVDNRFLLVMLASKRVKQLYKGASPLIDNKAANKNVVVSLREIASGKVGYELTSRKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T87</accession>
    <name>Q39T87_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver CheY associated with MCPs of class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY40H-1</name>
        <name evidence="3" type="ordered locus">Gmet_2312</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513308.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2312"/>
    <dbReference type="EnsemblBacteria" id="ABB32537">
        <property type="protein sequence ID" value="ABB32537"/>
        <property type="gene ID" value="Gmet_2312"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2312"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="ANFYLVK"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="121" mass="13452" checksum="3A5AE339399A77BC" modified="2005-11-22" version="1">MKKILIAEDSSTMRSLLVATIESLGGYLVSEAASGFEALRLLPREPVDLIITDINMPDINGLELVSFVRGSENYRHIPLFIISTEGSERDREKGLALGANEYLVKPFDPARLQELIKQYTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TD5</accession>
    <name>Q39TD5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">etfB-6</name>
        <name evidence="4" type="ordered locus">Gmet_2263</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366019.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2263"/>
    <dbReference type="EnsemblBacteria" id="ABB32489">
        <property type="protein sequence ID" value="ABB32489"/>
        <property type="gene ID" value="Gmet_2263"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2263"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_1_0_7"/>
    <dbReference type="OMA" id="MTPGGIF"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="258" mass="27617" checksum="075FB3FC3586C5FD" modified="2005-11-22" version="1">MKILVCIKQVPDMESRFKPGAGGTWYDESDLAWRMNEYDEFAVEQAVQLREQLGEGSELTVLSIGPDRVGEAIKKALAMGCDRGVHIQDNAAAMKDPWQIAAIIAAYAKDKGYDLIFTGMQSQDRGSALVGVTVAEELGYACATTLVGFAYADGSVTGKRELEGGIKGVVKLATPALVTCQLGLNVPRYPTLPNIMKAKKKDIQAIPVAELLKEEPLAATVSFHPPAKKGGGIVLEGEVGALVDQLMGILKEKTAVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TE6</accession>
    <name>Q39TE6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366005.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2251"/>
    <dbReference type="EnsemblBacteria" id="ABB32478">
        <property type="protein sequence ID" value="ABB32478"/>
        <property type="gene ID" value="Gmet_2251"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2251"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_9_7"/>
    <dbReference type="OMA" id="MARWACL"/>
    <dbReference type="OrthoDB" id="1594866at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="441" mass="45935" checksum="297CF4467FF305FC" modified="2005-11-22" version="1">MAQQATRFYGWTLVGMFFGIYFLNATFPYVGASVINSYMAESIGITKSIVGLGFSLFVLSSALSGPLVAYCVNKKGIRFTLASGGLIVAFGALLMALTVSKGWQYVLTFGVVIGTGVGLGTVIPIQTGVTNWFVRRRALAMSIALSAAGFGSFIAAPLLNKIIAASNGNWKNGWLVVVATGLAAATIAAGGVRNTPASMGQFPDGVPPGKSSENTARNAQVRSSRIYQSSEFWPVREVLKTKIFWLIIIASFSFLAVFNTCVAHGVIHLRSLGHSPQFAALSAGLLLLCSVGGKLFAGILGDRIEPRFILSAAVFSTLLGAVALANATNTAVVYLYACCVGVGFGASFVAMPTILANYYGVKSFAPLMGVALPLTNGGSAIAPLLAGIVYDRFGSYVLALYGGATIALLGAILVLFAKPPVSNAVVTVESKLDDKIGADFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TE7</accession>
    <name>Q39TE7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thiol:disulfide interchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the thioredoxin family. DsbC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2250"/>
    <dbReference type="EnsemblBacteria" id="ABB32477">
        <property type="protein sequence ID" value="ABB32477"/>
        <property type="gene ID" value="Gmet_2250"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2250"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083593_1_1_7"/>
    <dbReference type="OMA" id="EINRIKW"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03020">
        <property type="entry name" value="DsbA_DsbC_DsbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033954">
        <property type="entry name" value="DiS-bond_Isoase_DsbC/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018950">
        <property type="entry name" value="DiS-bond_isomerase_DsbC/G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009094">
        <property type="entry name" value="DiS-bond_isomerase_DsbC/G_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10411">
        <property type="entry name" value="DsbC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54423">
        <property type="entry name" value="SSF54423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010001743" description="Thiol:disulfide interchange protein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="DsbC_N" evidence="6">
        <location>
            <begin position="58"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="7">
        <location>
            <begin position="143"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="284" mass="31216" checksum="8821ED895A1C4BB8" modified="2005-11-22" version="1">MHQMIRFFWGGNMKWLMRILLPFAFVSTAYGFGTGTEGCSGNCIACHTIKKEEVVALVKNVDPATTVESVGPSPVRGLFEIIIRHNDSTGIIYLDFSKKFLIAGRILDTGSKKDVTATALNRVRRIDPSKLPLDNALVLGNATGSRNIYVFTDPECPFCAKFHRELVALTKEDPQLGVRIILTPLDIHPRASAVTNSILCAAQDGMDKGLRLLEESFNGTAIADITCGRDYAEEGKTLFKELRIRMTPTTVLSDGRVVDGVKTGAEIEKLFDDTEHGVITEKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TN7</accession>
    <name>Q39TN7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional response regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2158</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513047.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2158"/>
    <dbReference type="EnsemblBacteria" id="ABB32387">
        <property type="protein sequence ID" value="ABB32387"/>
        <property type="gene ID" value="Gmet_2158"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2158"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_90_1_7"/>
    <dbReference type="OMA" id="HVHRILQ"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00622">
        <property type="entry name" value="HTH_LUXR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="HTH luxR-type" evidence="3">
        <location>
            <begin position="143"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="210" mass="23156" checksum="E05455C95B256306" modified="2005-11-22" version="1">MSTRILVADDHAIFREGLKQVIGTTVDMSVVDEAVDGKELLNKIQANDYDMVILDITMPGRNGLDVLTEMKSIKPKLPVLVMSMHPEEQYALRAYKSGAAGYLNKGSASNELLDALHKISMGKKYVSSALAESLVSGLSDHNQQDLLQSLSNREYQVMSMIASGKTVGKIATELSLSVKTVSTYRAHILRKLNMKNNAELTRFVIENKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TP6</accession>
    <name>Q39TP6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bamS</name>
        <name evidence="2" type="ordered locus">Gmet_2149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513056.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2149"/>
    <dbReference type="EnsemblBacteria" id="ABB32378">
        <property type="protein sequence ID" value="ABB32378"/>
        <property type="gene ID" value="Gmet_2149"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2149"/>
    <dbReference type="eggNOG" id="COG1462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929872_0_0_7"/>
    <dbReference type="OrthoDB" id="937181at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223385" evidence="1">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="299" mass="30984" checksum="D36CD48FD73ADB78" modified="2005-11-22" version="1">MGTLRYVALLALLTVTACAGPRTATGPSEEYVEVDNPAYTMSPNASPTMWVPRRYVESGIPRGSQLVKKGYEEVVGKGAPAPASQVAAAVSPRLRIAVVQAGGNELAAGLGEKLRGAGFALVGEPRPEGALSVPASVEERGAYVQSLNRNREFNAVVFIGSLKGEGGGSLLVAEMYDGMGGILLRRIEVPVSSQGESAASLDAVADKVRGVARHIPWLCGIAAVEGEKVYINAGRESGVVIGQRLRIYRGGKGIKGLGFDPGSKVGTLEVTGFVGPNGAYGIVREGEGARTSDLVGSDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TP9</accession>
    <name>Q39TP9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">bamV</name>
        <name evidence="11" type="ordered locus">Gmet_2146</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513059.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39TP9"/>
    <dbReference type="STRING" id="269799.Gmet_2146"/>
    <dbReference type="EnsemblBacteria" id="ABB32375">
        <property type="protein sequence ID" value="ABB32375"/>
        <property type="gene ID" value="Gmet_2146"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2146"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453271_0_0_7"/>
    <dbReference type="OMA" id="SAIQMNM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="384"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="603" mass="67228" checksum="C15257320372E26B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TY8</accession>
    <name>Q39TY8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2057</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514046.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2057"/>
    <dbReference type="EnsemblBacteria" id="ABB32286">
        <property type="protein sequence ID" value="ABB32286"/>
        <property type="gene ID" value="Gmet_2057"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2057"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_2_7"/>
    <dbReference type="OMA" id="NPPHAVR"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="278" mass="29718" checksum="3E9AD5132CA0DAC3" modified="2005-11-22" version="1">MNGEALTIAAVPLLQDSSLELHGGVAVLTFQRDDVRNALTGTALVDDLVRTVQWANTSTEVSVLVITGAGAAFSSGGNVKEMQEKSGIFAGGPIDVQNQYRRGIQQVPLALHKAEIPVIAAVNGPAMGAGLDLACMCDIRIASDKALIGGTFINLGIIPGDGGAWFLPRLVGYQRAAEMLFTGRIMKAAEALQLGLFLEVVEPEELLPRARELAGQIAAKPPQALRLMKRLLKLAQRNDLPDFLDATACFQAMAHHSDDHLEAVTAFLEKRAPRYSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U52</accession>
    <name>Q39U52_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512957.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1993"/>
    <dbReference type="EnsemblBacteria" id="ABB32222">
        <property type="protein sequence ID" value="ABB32222"/>
        <property type="gene ID" value="Gmet_1993"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1993"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024784_1_0_7"/>
    <dbReference type="OMA" id="FNRMSAF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014265">
        <property type="entry name" value="Sig_transdc_His_kin_PEP-CTERM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02916">
        <property type="entry name" value="PEP_his_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="484"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="696" mass="76749" checksum="30BE0A011120B345" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U74</accession>
    <name>Q39U74_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA methyltransferase, TrmA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365894.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1971"/>
    <dbReference type="EnsemblBacteria" id="ABB32200">
        <property type="protein sequence ID" value="ABB32200"/>
        <property type="gene ID" value="Gmet_1971"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1971"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_0_7"/>
    <dbReference type="OMA" id="YCGVGGF"/>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="7">
        <location>
            <begin position="15"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="493" mass="53971" checksum="038285E6DEAD8EAB" modified="2005-11-22" version="1">MTTRYRKREDNRNHRTATGQTVTLTITGFDDEGFGTTSHEGKKVLVAGALPGETVSIRVTHNGPRTMFGEAITILSPSPDRMASPSCTTSACSNCPLISMNYGAQLTLKRSLVEKEIRSFASLRAVPIDDVISSPRPLQYRNSAKLVVAGTFKSPIIGIYRRNSHNVVDISACPLHNPLINRVVAAAKEGIRKGKVPVYNPRTDTGILRYLVVRVSEHTGRAMAVFVTAQRSYNEIHHLAKFVRQAVPELDVAVQNVNTSEGNVILAPHDHFLTKDHAIIEELAGIRFSISPRSFFQVNSGSARIIYEKVREWSALTGNEKVVDLYCGIGGISLFLAPGAQEVHGIEYVDAAVADAERNARLNGIRNCSFEAGDAAELLEELVEEGTEPDVVIFNPPRKGCDRRVLEAAVNSGPGRMIYVSCSPATLARDLDILAGLGYQTREIQPVDMFPQTPHIENVALLVDARHARDDHGKTTSPQGRQHFTHKRRGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U75</accession>
    <name>Q39U75_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511874.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1970"/>
    <dbReference type="EnsemblBacteria" id="ABB32199">
        <property type="protein sequence ID" value="ABB32199"/>
        <property type="gene ID" value="Gmet_1970"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1970"/>
    <dbReference type="eggNOG" id="COG4267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043533_1_1_7"/>
    <dbReference type="OMA" id="ITQFQVS"/>
    <dbReference type="OrthoDB" id="859701at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031617">
        <property type="entry name" value="PelG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16933">
        <property type="entry name" value="PelG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="456" mass="51812" checksum="4C2C47E76DFBBC9B" modified="2005-11-22" version="1">MAGIGFELRKLLKRDTFFSLLQTYGYAGIISSGPWVLSIFAVMLIGFISLPVVIPPVLVSQFQTSITYLIALSLIYTGLFQLAFTRYSADRIFEKEHFRLLPNLNGLLLLVTTVGGLVSFPLAIVLFPQTSLIYRLLFATTFVTVSCVWMAAILLSGLKAYKTILYNFALGYGTALFLAFFLRTWKLEGLLLAFLTGQFVLLKGMLFVIFRNYPSRTFVEFDFLRKRRVHYSLMLTGFFYNLAIWADKFVFWFHPYTGSNVIGPLHASEIYDFPIFLAYLSILPGMAVFLVRMETDFVEYYDRFYDSVREGGSLTTIQAMKNEMVHTAREGIYDIIKVQSIATIIIFLFGPAMLSLAGISLVYVPLLNIDVVSTGLQVVLLGLINIYFYLDRRERALLLTVLFATLNFILSIISINLGPYFYGYGFAGSLCITIMCGMFLLDRDLDTLEYKTFMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UA4</accession>
    <name>Q39UA4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit PurL</fullName>
            <shortName evidence="8">FGAM synthase</shortName>
            <ecNumber evidence="8">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Formylglycinamide ribonucleotide amidotransferase subunit II</fullName>
            <shortName evidence="8">FGAR amidotransferase II</shortName>
            <shortName evidence="8">FGAR-AT II</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glutamine amidotransferase PurL</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Phosphoribosylformylglycinamidine synthase subunit II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">purL</name>
        <name evidence="12" type="synonym">purSL</name>
        <name evidence="12" type="ordered locus">Gmet_1941</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O + L-glutamine + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ADP + H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511902.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1941"/>
    <dbReference type="EnsemblBacteria" id="ABB32170">
        <property type="protein sequence ID" value="ABB32170"/>
        <property type="gene ID" value="Gmet_1941"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1941"/>
    <dbReference type="eggNOG" id="COG0046">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003100_0_0_7"/>
    <dbReference type="OMA" id="FIEPYQG"/>
    <dbReference type="OrthoDB" id="26038at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00420">
        <property type="entry name" value="PurL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010074">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003850">
        <property type="entry name" value="PurS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43555">
        <property type="entry name" value="PTHR43555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02700">
        <property type="entry name" value="PurS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="SSF82697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01736">
        <property type="entry name" value="FGAM_synth_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 8" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FGAR-AT_linker" evidence="11">
        <location>
            <begin position="193"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="9">
        <location>
            <begin position="309"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="10">
        <location>
            <begin position="439"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS" evidence="9">
        <location>
            <begin position="679"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="10">
        <location>
            <begin position="823"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="737"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="781"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="784"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="996" mass="108760" checksum="117EAF51C107687A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UE7</accession>
    <name>Q39UE7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">ATP phosphoribosyltransferase</fullName>
            <shortName evidence="11">ATP-PRT</shortName>
            <shortName evidence="11">ATP-PRTase</shortName>
            <ecNumber evidence="4 11">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hisG</name>
        <name evidence="14" type="synonym">hisGL</name>
        <name evidence="14" type="ordered locus">Gmet_1898</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 11">Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Feedback inhibited by histidine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ATP phosphoribosyltransferase family. Long subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="4 11"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511946.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1898"/>
    <dbReference type="EnsemblBacteria" id="ABB32127">
        <property type="protein sequence ID" value="ABB32127"/>
        <property type="gene ID" value="Gmet_1898"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1898"/>
    <dbReference type="eggNOG" id="COG0040">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038115_1_1_7"/>
    <dbReference type="OMA" id="VASKFVH"/>
    <dbReference type="OrthoDB" id="1419568at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP_PRibTrfase_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="PTHR21403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HisG" evidence="12">
        <location>
            <begin position="51"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HisG_C" evidence="13">
        <location>
            <begin position="217"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="291" mass="32253" checksum="C92521D2BBAAB89C" modified="2005-11-22" version="1">MSNLLNLGIPKGSLENATVELFRKSGWQISISSRSYFPGVDDDELNCKLIRPQEMGKYVERGTIDAGIAGRDWVRENDSDVVEVCEMVYSKVSRRPARWVLVVTKDSTVQKPEDLHGATISTELVGFTKRYFAERNIPVNVEFSWGATEAKVVDGLCDAIVEVTETGSTIKANGLRIVCDLMESVPVLIANKAAWADPWKRQKIETIATLLKASLAAEGMVGLKMNAPNDKVEAITEILPSLNRPTVSHLYKSEWVSIESVLHEKEVRRIVPQLLALGAQGIIEYSLNKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UE9</accession>
    <name>Q39UE9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="3 13">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">lpdA-2</name>
        <name evidence="16" type="ordered locus">Gmet_1896</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NAD(+) = (R)-N(6)-lipoyl-L-lysyl-[protein] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11 13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="13">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="3 13"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511948.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1896"/>
    <dbReference type="EnsemblBacteria" id="ABB32125">
        <property type="protein sequence ID" value="ABB32125"/>
        <property type="gene ID" value="Gmet_1896"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1896"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_0_2_7"/>
    <dbReference type="OMA" id="RIAAYAM"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 11 13" id="KW-0274">FAD</keyword>
    <keyword evidence="4 13" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 11 13" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="15">
        <location>
            <begin position="4"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="14">
        <location>
            <begin position="344"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="437"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB32125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="452" mass="47660" checksum="D20BC364D7DEF83D" modified="2005-11-22" version="1">MKSFDVVIIGGGPGGINAGIMLSKAGKNVALIQEEAVSFGGTCLNSGCMPTKSLLKAATAYRYAKQAERYGLDLQAGPVDLGKLCAVTETDLNMLRGAIKGMLAETSITAFRGNGSFASEHEVTVTMAGGEQETIWGETIIIATGSSPRELPSAPFDGLHILSSDQMLTNTDLPKKLLIVGGGAIGCEFATLYKTFGSEVVLIEAMETLLPREDRDAGKKLQAAFEAQGITVRTGTSIDRLIVVDEKIRIQFDNGDSIDSIDKVLVGIGRAPNIEGLNLEAAGLRTEHGAVKVNELMQTNVPHIYAIGDVTGGLTLAHAAQREAQLLVQNLLHGSSHALKELAVPRVAFSYPEVAAVGASQEGNGIRAYTLPQVPNGRSVVDKVAPAFVKLFLKEQTSEIAGAVIIGEAATEIIHEMALAVENGLTLQQVGNTVHVHPTHSKNILYAIQSCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UL4</accession>
    <name>Q39UL4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1831"/>
    <dbReference type="EnsemblBacteria" id="ABB32060">
        <property type="protein sequence ID" value="ABB32060"/>
        <property type="gene ID" value="Gmet_1831"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1831"/>
    <dbReference type="HOGENOM" id="CLU_1765410_0_0_7"/>
    <dbReference type="OMA" id="RAPCFDT"/>
    <dbReference type="OrthoDB" id="2188289at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223289" evidence="1">
        <location>
            <begin position="22"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="16170" checksum="6A9172573002CC6E" modified="2005-11-22" version="1">MKSAVPLLLLSALLISIPVSVYPQASSIQEEEIGTVRLGGRAPCFDTRVRRELDSFVSRLATLDSGRVVKIEANASWGASREERVRNSLLLALEAHRYLRSRLRSGLNLYIAAASSREAEKTTFIRVVSFPDSFATAHVSTVGNRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UL6</accession>
    <name>Q39UL6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium/phosphate symporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1829</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512016.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1829"/>
    <dbReference type="EnsemblBacteria" id="ABB32058">
        <property type="protein sequence ID" value="ABB32058"/>
        <property type="gene ID" value="Gmet_1829"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1829"/>
    <dbReference type="eggNOG" id="COG1283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025623_2_0_7"/>
    <dbReference type="OMA" id="TWACHSS"/>
    <dbReference type="OrthoDB" id="1341748at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015114">
        <property type="term" value="F:phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005436">
        <property type="term" value="F:sodium:phosphate symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044341">
        <property type="term" value="P:sodium-dependent phosphate transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003841">
        <property type="entry name" value="Na/Pi_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030147">
        <property type="entry name" value="NptA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010">
        <property type="entry name" value="PTHR10010"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10010:SF46">
        <property type="entry name" value="PTHR10010:SF46"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02690">
        <property type="entry name" value="Na_Pi_cotrans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="6">
        <location>
            <begin position="349"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="543" mass="59024" checksum="64B047D1E91B27C0" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UU3</accession>
    <name>Q39UU3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase, S49 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S49 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513354.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1750"/>
    <dbReference type="DNASU" id="3741426"/>
    <dbReference type="EnsemblBacteria" id="ABB31981">
        <property type="protein sequence ID" value="ABB31981"/>
        <property type="gene ID" value="Gmet_1750"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1750"/>
    <dbReference type="eggNOG" id="COG0616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046540_0_0_7"/>
    <dbReference type="OMA" id="YVYDEIR"/>
    <dbReference type="OrthoDB" id="1318587at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07023">
        <property type="entry name" value="S49_Sppa_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004635">
        <property type="entry name" value="Pept_S49_SppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002142">
        <property type="entry name" value="Peptidase_S49"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01343">
        <property type="entry name" value="Peptidase_S49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00706">
        <property type="entry name" value="SppA_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_S49" evidence="2">
        <location>
            <begin position="97"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="301" mass="32252" checksum="A2837B5FC8F3B5D2" modified="2005-11-22" version="1">MKKNHVVIGVIIVAALALLFTLSIQIARLILGDGPMVSSGEGVGYVEVKGPILESEEIVKQLSEMRKKTNVKAVVLRIESPGGVIGPSQEIYEAVKKLAKTKKVVVSMGSVAASGGYHIAIPAAVIYANPGTITGSIGVLMKLANVEGLMDKVGMKAFTLKSGKFKDAGSPVRALTDEDRALLQGVIDNLHTQFVKAVAEARKLPVEEVRRLADGRVYTGEQAVSLKLVDRLGTLEDAVEEAGRLAGIKGEPTLLMPPKKRKHLRDYLLEEASGFFREIVRREGGFSVNYELDPAVGNGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V34</accession>
    <name>Q39V34_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Creatinine amidohydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the creatininase superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511404.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1659"/>
    <dbReference type="DNASU" id="3740509"/>
    <dbReference type="EnsemblBacteria" id="ABB31890">
        <property type="protein sequence ID" value="ABB31890"/>
        <property type="gene ID" value="Gmet_1659"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1659"/>
    <dbReference type="eggNOG" id="COG1402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055029_3_1_7"/>
    <dbReference type="OMA" id="YAIEWMW"/>
    <dbReference type="OrthoDB" id="984747at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024087">
        <property type="entry name" value="Creatininase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003785">
        <property type="entry name" value="Creatininase/forma_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35005">
        <property type="entry name" value="PTHR35005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02633">
        <property type="entry name" value="Creatininase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102215">
        <property type="entry name" value="SSF102215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="239" mass="26430" checksum="C4DF709A37848DD1" modified="2005-11-22" version="1">MIVETMTMVEFEEGLKRTRTVFVPFGSVEEHGCHLPLSTDTIQAYEVGKKAALQISLFVAPPIHYGSCRSTSCHPGTISITTATLKCLMKDIVRSLYAQGMRNFIILTGHAGGSHRMALQDAGEELLPEIPDIRIAVVTEYELASREGKGIIETEGDAHAGEIETSRILHTHPHLVQGRGEREFPSFPTGILVRNKRKYWPNGVWGDPAKATAEKGKRLEELVVKKIVELAAALEQFQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V60</accession>
    <name>Q39V60_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF58 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1633</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31864.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365853.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1633"/>
    <dbReference type="EnsemblBacteria" id="ABB31864">
        <property type="protein sequence ID" value="ABB31864"/>
        <property type="gene ID" value="Gmet_1633"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1633"/>
    <dbReference type="eggNOG" id="COG1721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054568_1_0_7"/>
    <dbReference type="OMA" id="TTTWPLG"/>
    <dbReference type="OrthoDB" id="848990at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002881">
        <property type="entry name" value="DUF58"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01882">
        <property type="entry name" value="DUF58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="DUF58" evidence="2">
        <location>
            <begin position="184"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31864.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="288" mass="31696" checksum="3179342700269C6F" modified="2012-10-31" version="2">MKLTRAGAAYIAITLLLGFAAVNTGNNLLFLVVSALLGFMTVSGILGWLNIRYLDVAVRLPDEIYDGQETYVTLMVENRKRLLPSFLLRIGVEEAHADFHLVERSATESGTLAMTFKGRGRKELIQAVVSSPFPINFFIRSTTLPLDARCIVFPRPRPCGPPEGPADARSRGAARSVGRGYEGEMETIADYTGVEPLKLIHWRLSARHENLKVKRLTSLADVPLMIDVAQLPGQSLDERLSCGAWIVNRSIRVNRPVGLITGTKVIGPDTSRLHRLKLLTELALHGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V63</accession>
    <name>Q39V63_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511434.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1630"/>
    <dbReference type="EnsemblBacteria" id="ABB31861">
        <property type="protein sequence ID" value="ABB31861"/>
        <property type="gene ID" value="Gmet_1630"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1630"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106706_0_0_7"/>
    <dbReference type="OMA" id="HDYGFPK"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="228" mass="26145" checksum="9099D7650E603F42" modified="2005-11-22" version="1">MTIDWNQIDTVLLDMDGTLLDRHFDDHFWLEHVPKRYAAKNGIPLDTAKKSLYAQFRSQERTLNWTDLDYWSDRLGLDIPLLKLEVEHLIAVHPGVVEFLLFLRQHAKEIWLVTNAHGKTLDIKMRKTRIGPYFTGIVSAHEVGLPKEDVAFWGMLRKTVPYDPARTMLGEDSETNLGTAEAYGISHLIYVSRYSSTVHPLPSERFASIHYFNQLIPSPDTSSVSLNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V79</accession>
    <name>Q39V79_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cation-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511450.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1614"/>
    <dbReference type="EnsemblBacteria" id="ABB31845">
        <property type="protein sequence ID" value="ABB31845"/>
        <property type="gene ID" value="Gmet_1614"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1614"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_3_0_7"/>
    <dbReference type="OMA" id="RRFLTYH"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="671"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="698"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="804"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="844"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="8">
        <location>
            <begin position="2"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="871" mass="94236" checksum="9C2E125637F9EF3D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V99</accession>
    <name>DUT_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="1">dUTPase</shortName>
            <ecNumber evidence="1">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dut</name>
        <name type="ordered locus">Gmet_1593</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dUTP + H2O = diphosphate + dUMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the dUTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511472.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V99"/>
    <dbReference type="SMR" id="Q39V99"/>
    <dbReference type="STRING" id="269799.Gmet_1593"/>
    <dbReference type="EnsemblBacteria" id="ABB31825">
        <property type="protein sequence ID" value="ABB31825"/>
        <property type="gene ID" value="Gmet_1593"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1593"/>
    <dbReference type="eggNOG" id="COG0756">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068508_1_2_7"/>
    <dbReference type="OMA" id="YAAFVHP"/>
    <dbReference type="OrthoDB" id="1669228at2"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00116">
        <property type="entry name" value="dUTPase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="PTHR11241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="SSF51283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000231410" description="Deoxyuridine 5'-triphosphate nucleotidohydrolase">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="85"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00116"/>
        </source>
    </evidence>
    <sequence length="148" mass="16014" checksum="D7618826786C75E5" modified="2005-11-22" version="1">MERCVVKVRRVRGGDQNLPCYMTVHAAGMDLCADLVDDLVLNPGERKLVPTGLAIALPDGFEAQIRPRSGLALKHGIALVNSPGTIDPDYRGEIGVILINHGSEPFVVRRGERIAQMVFAPFARAELVEVDELDETARGEGGFGHTGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VB0</accession>
    <name>BIOB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biotin synthase</fullName>
            <ecNumber evidence="1">2.8.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bioB</name>
        <name type="ordered locus">Gmet_1582</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4R,5S)-dethiobiotin + [sulfur carrier]-SH + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2 5'-deoxyadenosine + [sulfur carrier]-H + biotin + 2 L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:22060"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="EC" id="2.8.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. Biotin synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511483.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VB0"/>
    <dbReference type="SMR" id="Q39VB0"/>
    <dbReference type="STRING" id="269799.Gmet_1582"/>
    <dbReference type="EnsemblBacteria" id="ABB31814">
        <property type="protein sequence ID" value="ABB31814"/>
        <property type="gene ID" value="Gmet_1582"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1582"/>
    <dbReference type="eggNOG" id="COG0502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033172_2_1_7"/>
    <dbReference type="OMA" id="ADRFCMG"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00162"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004076">
        <property type="term" value="F:biotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01694">
        <property type="entry name" value="BioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010722">
        <property type="entry name" value="BATS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002684">
        <property type="entry name" value="Biotin_synth/BioAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024177">
        <property type="entry name" value="Biotin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22976">
        <property type="entry name" value="PTHR22976"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06968">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001619">
        <property type="entry name" value="Biotin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00876">
        <property type="entry name" value="BATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00433">
        <property type="entry name" value="bioB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0093">Biotin biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000381403" description="Biotin synthase">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="48"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="329" mass="35556" checksum="96821AFEB035E61E" modified="2005-11-22" version="1">MNKSLETLAGRIIAGEQLSVEESIALSASSGTDAFALFLAASRVKEHFLGNGVDLCSIINAKSGRCPENCAFCAQSAHHTTNAPIYPLVDEDKLVACAKEAEAAGSRCYGIITSGTTIKKGEELDRICRAVRRIRETTSIAPSCSLGIIDHETAVTLREAGVETYHHNLETSRSFFPHICTTHDYEEDVETVRVAKQAGLTICCGGIFGLGETAAQRVELAMTLRELDVDSVPLNFLNPIEGTRLAGSKLISPLECLKTIALFRLILPTKKIAVCGGREQNLRDLQSWIFFAGASGTMIGNYLTTTGRPAEQDWQMLRDLELAVGGCCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VF2</accession>
    <name>Q39VF2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(R)-benzylsuccinate synthase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bssB</name>
        <name evidence="3" type="ordered locus">Gmet_1538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1538"/>
    <dbReference type="EnsemblBacteria" id="ABB31772">
        <property type="protein sequence ID" value="ABB31772"/>
        <property type="gene ID" value="Gmet_1538"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1538"/>
    <dbReference type="eggNOG" id="ENOG50334I0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2679661_0_0_7"/>
    <dbReference type="OMA" id="SCKWQIA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040565">
        <property type="entry name" value="BssB_TutG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18512">
        <property type="entry name" value="BssB_TutG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BssB_TutG" evidence="2">
        <location>
            <begin position="21"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="86" mass="9540" checksum="58ECA25883067D81" modified="2005-11-22" version="1">MSPRGPGQEATVSATSNGNMMHEEPGTKKPCQSCKWQIADPTNPLRGQCTVNRNAMGGVWKRWVTDVNRMTCGKHEVGKLSFREHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VF9</accession>
    <name>Q39VF9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-[hydroxy(Phenyl)methyl]-succinyl-CoA dehydrogenase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bbsD</name>
        <name evidence="1" type="ordered locus">Gmet_1531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511536.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1531"/>
    <dbReference type="EnsemblBacteria" id="ABB31765">
        <property type="protein sequence ID" value="ABB31765"/>
        <property type="gene ID" value="Gmet_1531"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1531"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="HEHQPRV"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="249" mass="26302" checksum="C03F150B238BC0AE" modified="2005-11-22" version="1">MAGLQGKVALITGSASGMGKKTAQRLAEKGVKIVINDIVSEKVDQTVKEFSAQGFEVMGVVADICKTSAVQEMVKSAVERFGSLDILVNNAGMERAGALRNLSETDWDLTVDVNLKGAFLCSQAAHGHMIEQGGGRIVNIASRAWLGGAGQAPYSSAKAGLVGLTRTLALELGRKGVTVNCIAPGLIHTPMWDELPEKNRLGFLAKQPMGKIGEDEDIANAVLFFLDDEASFITGQVFYVCGGRSLFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VH4</accession>
    <name>Q39VH4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511551.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1516"/>
    <dbReference type="EnsemblBacteria" id="ABB31750">
        <property type="protein sequence ID" value="ABB31750"/>
        <property type="gene ID" value="Gmet_1516"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1516"/>
    <dbReference type="HOGENOM" id="CLU_1882782_0_0_7"/>
    <dbReference type="OMA" id="LVHIIFP"/>
    <dbReference type="OrthoDB" id="1843642at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="135" mass="15075" checksum="F4EFE5EF31682E8C" modified="2005-11-22" version="1">MAEVAIKIGGILSALVGIGHCSFYRGFGWREDFAGTKILTARVLYTIHLFLIPMFLFFAYASLFHTSELAGGTPLGVAMSTFYASFWLFRLIWQVVYFRPAQIPELGRLLPLHYFLIVSFVVLAAAYGVPLTMQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VP4</accession>
    <name>Q39VP4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide chain length determinant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511623.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1446"/>
    <dbReference type="EnsemblBacteria" id="ABB31680">
        <property type="protein sequence ID" value="ABB31680"/>
        <property type="gene ID" value="Gmet_1446"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1446"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_5_0_7"/>
    <dbReference type="OMA" id="MRDHDNA"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="418"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="317"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="519" mass="58600" checksum="7CD35D74D1064BDF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VP7</accession>
    <name>Q39VP7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511626.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1443"/>
    <dbReference type="EnsemblBacteria" id="ABB31677">
        <property type="protein sequence ID" value="ABB31677"/>
        <property type="gene ID" value="Gmet_1443"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1443"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_5_5_7"/>
    <dbReference type="OMA" id="ICTNPPM"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="189" mass="20478" checksum="DB7FCA45F852E41D" modified="2005-11-22" version="1">MKQSLGAKTLLFPTPVLMVGTYDHAGKPNLMNAAWGGICCSDPPCVTVSVRKSRHTYDSIVERQAFTVGIANEATMAEADYVGIASGRDADKFAVAGLTPVRSELVDAPYAEEFPVVLECRLLHTLEIGIHTQFIGEIIDVKADKNILSEDGLPDILKIQPLVFDTAHRGYHAVGPLLDRAYSVGKKLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VQ1</accession>
    <name>LEXA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LexA repressor</fullName>
            <ecNumber evidence="1">3.4.21.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lexA</name>
        <name type="ordered locus">Gmet_1439</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of Ala-|-Gly bond in repressor LexA.</text>
            <dbReference type="EC" id="3.4.21.88"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S24 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.88" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511630.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VQ1"/>
    <dbReference type="SMR" id="Q39VQ1"/>
    <dbReference type="STRING" id="269799.Gmet_1439"/>
    <dbReference type="MEROPS" id="S24.001"/>
    <dbReference type="EnsemblBacteria" id="ABB31673">
        <property type="protein sequence ID" value="ABB31673"/>
        <property type="gene ID" value="Gmet_1439"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1439"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_45_1_7"/>
    <dbReference type="OMA" id="EGVFCGL"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00015">
        <property type="entry name" value="LexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006200">
        <property type="entry name" value="LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006199">
        <property type="entry name" value="LexA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006197">
        <property type="entry name" value="Peptidase_S24_LexA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01726">
        <property type="entry name" value="LexA_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00726">
        <property type="entry name" value="LEXASERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00498">
        <property type="entry name" value="lexA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000001286" description="LexA repressor">
        <location>
            <begin position="1"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="For autocatalytic cleavage activity" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="1">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00015"/>
        </source>
    </evidence>
    <sequence length="201" mass="22020" checksum="BA65B5A646E86711" modified="2005-11-22" version="1">MEELTPRQNEVLRFLEGYLTQYGYPPTMRDIAAHLRISGTLGVSKHLTALERKGYIRRDPGNSRGISLVGHGSKSASLPIAGVVRAGMLQPAIEDIEGYLAIDQAQLKGGKFFLRVKGDSMVNAAILDGDLALIRPQPTAENNDIVVAMVDGEATLKAFYRERGQIRLQPRNPNMEPIIIREGEGEVAIVGKVVGIFRTLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VQ2</accession>
    <name>Q39VQ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GIY-YIG domain nuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1438"/>
    <dbReference type="EnsemblBacteria" id="ABB31672">
        <property type="protein sequence ID" value="ABB31672"/>
        <property type="gene ID" value="Gmet_1438"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1438"/>
    <dbReference type="eggNOG" id="COG2827">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135650_0_3_7"/>
    <dbReference type="OMA" id="RLYTGIT"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="86" mass="9853" checksum="8584CF8AA19236C9" modified="2005-11-22" version="1">MSWQVYIILCSDNSLYTGITTDLDRRFRQHAGGTGAKYFRGRRPLRVVYLENDHSRSSAASREAKIKAMGRTEKMNLITTTSLRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VV8</accession>
    <name>Q39VV8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arylsulfotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1382</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513126.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1382"/>
    <dbReference type="EnsemblBacteria" id="ABB31616">
        <property type="protein sequence ID" value="ABB31616"/>
        <property type="gene ID" value="Gmet_1382"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1382"/>
    <dbReference type="eggNOG" id="ENOG502ZAQ1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026635_2_0_7"/>
    <dbReference type="OMA" id="WILAANK"/>
    <dbReference type="OrthoDB" id="272464at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004062">
        <property type="term" value="F:aryl sulfotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035391">
        <property type="entry name" value="Arylsulfotran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010262">
        <property type="entry name" value="Arylsulfotransferase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038477">
        <property type="entry name" value="ASST_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17425">
        <property type="entry name" value="Arylsulfotran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05935">
        <property type="entry name" value="Arylsulfotrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223190" evidence="1">
        <location>
            <begin position="35"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="domain" description="Arylsulfotran_N" evidence="2">
        <location>
            <begin position="54"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="625" mass="69797" checksum="07456386497F56B3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VZ1</accession>
    <name>Q39VZ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP-dependent helicase HrpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hrpB</name>
        <name evidence="3" type="ordered locus">Gmet_1349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513159.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1349"/>
    <dbReference type="EnsemblBacteria" id="ABB31583">
        <property type="protein sequence ID" value="ABB31583"/>
        <property type="gene ID" value="Gmet_1349"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1349"/>
    <dbReference type="eggNOG" id="COG1643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001832_5_6_7"/>
    <dbReference type="OMA" id="DLRILVM"/>
    <dbReference type="OrthoDB" id="604268at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010225">
        <property type="entry name" value="HrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013689">
        <property type="entry name" value="RNA_helicase_ATP-dep_HrpB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08482">
        <property type="entry name" value="HrpB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005496">
        <property type="entry name" value="ATP_hel_hrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01970">
        <property type="entry name" value="DEAH_box_HrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="203"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="842" mass="91878" checksum="1C7873B110AB5753" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W24</accession>
    <name>Q39W24_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1314</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514783.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1314"/>
    <dbReference type="EnsemblBacteria" id="ABB31550">
        <property type="protein sequence ID" value="ABB31550"/>
        <property type="gene ID" value="Gmet_1314"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1314"/>
    <dbReference type="eggNOG" id="COG2445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_1_2_7"/>
    <dbReference type="OMA" id="VLIESCI"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="142" mass="15896" checksum="CC01E7C2DD9881C3" modified="2005-11-22" version="1">MRLDLYQAETAYIAQEQTALLDEARAILLSERPLSRLEENGVLHAIQVLVENAIGKAKQLLKASGKQVPVSAYDSFHALADLGVIKVSSLAAWNATIGLRNRLVHDYMNIDMGRILELVRNEQYRFVTEFLMSPVQEVSDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W60</accession>
    <name>Q39W60_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arabinose-5-phosphate isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">kdsD</name>
        <name evidence="8" type="ordered locus">Gmet_1278</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SIS family. GutQ/KpsF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512089.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1278"/>
    <dbReference type="EnsemblBacteria" id="ABB31514">
        <property type="protein sequence ID" value="ABB31514"/>
        <property type="gene ID" value="Gmet_1278"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1278"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_13_1_7"/>
    <dbReference type="OMA" id="LMACLMR"/>
    <dbReference type="OrthoDB" id="571638at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05014">
        <property type="entry name" value="SIS_Kpsf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004800">
        <property type="entry name" value="KdsD/KpsF-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035474">
        <property type="entry name" value="SIS_Kpsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004692">
        <property type="entry name" value="KdsD_KpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00393">
        <property type="entry name" value="kpsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SIS" evidence="7">
        <location>
            <begin position="31"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="200"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="267"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="site" description="Catalytically relevant" evidence="4">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR004692-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="321" mass="33542" checksum="8BC0A2F31578626A" modified="2005-11-22" version="1">MIIEEARKVIRIEADALMALADSINGEFEQAVRRILSTKGRVVVTGMGKSGLIGQKIASTMASTGTPAFFLHPAEGIHGDLGMIMKGDVVIAISNSGETDEVVRILPIIKRLGASLISMSGNPKSSLAKAGDVFLDISVKEEACPLGLAPTASTTATLAMGDALAVALLLERGFRPEDFALFHPGGSLGKKLLLTVGDLMHAGDAVPIVTSDTPMRDALFVISSKGLGVTGVVDGSGALLGVITDGDLRRALSKGLAVLELPAGELMSRNPKRIKRGELAAKALQRMEQYSITSLFVFEGDDDAQPVGVIHLHDLLKAGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WA0</accession>
    <name>Q39WA0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Peptidase lipoprotein, M48 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1238</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31474.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512131.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1238"/>
    <dbReference type="MEROPS" id="M48.019"/>
    <dbReference type="DNASU" id="3738781"/>
    <dbReference type="EnsemblBacteria" id="ABB31474">
        <property type="protein sequence ID" value="ABB31474"/>
        <property type="gene ID" value="Gmet_1238"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1238"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029002_5_2_7"/>
    <dbReference type="OMA" id="QWEVNLI"/>
    <dbReference type="OrthoDB" id="1530824at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223367" evidence="7">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="8">
        <location>
            <begin position="61"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31474.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="265" mass="29483" checksum="1BA3F69FBB5CD235" modified="2012-10-31" version="2">MRFARLLLLPLIVIGTLSGCAVNMADIHGFNVISLEQEKELGTKFAAEIEKQYPVYNDPEAQKYVDRLGRRLLTGAREVSFDYVFKVVKDDSVNAFAIPGGRLYVHTGLLKAAQSETEVAAVMAHEISHAVARHGTRQMTQQYGYSLVLSLVLGQNSNMLAQIAGELFGKAGMMSYSRDYENQADFLGVETMSKAGYNPQGMVSFFQKLDTMGQQNPSALTKFFSSHPLTSERIQRVQAEIAQLPPRTYPPVDNTDLQKIRARIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WC8</accession>
    <name>Q39WC8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Peptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1209</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512161.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1209"/>
    <dbReference type="EnsemblBacteria" id="ABB31446">
        <property type="protein sequence ID" value="ABB31446"/>
        <property type="gene ID" value="Gmet_1209"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1209"/>
    <dbReference type="eggNOG" id="COG2931">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051348_0_0_7"/>
    <dbReference type="OMA" id="WDHGSAW"/>
    <dbReference type="OrthoDB" id="1232973at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005077">
        <property type="entry name" value="Peptidase_C11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37835">
        <property type="entry name" value="PTHR37835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03415">
        <property type="entry name" value="Peptidase_C11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="429" mass="46134" checksum="D6B5456BB5967B39" modified="2005-11-22" version="1">MPTKANTQRNWTIMVYLAGDNNLDSAGVVDLKEMKTVGTTDKIAVLAQFDRAGAKQATIRYCLKQGTPLAKDAVQSLGETNMGDPKVLEDFVTWGVANYPADHYLLVLWNHGAGWDDANLYQGDVFSGAAPPVSRKAQPVATRGATAGAKAIPLAQARAGIRRARRALFSTTVEAAIKQRGIAFDDQAQDFLDNIELKRVLTAIKKKLKRKIDIVGMDACLMSMAEVAYQMRDVADYSVGSEETEPGDGWPYDRILKALAAKPAMTPEELSKTIVAQYLASYKATENVTQSAMKLLALNPLATAVDGMAKALTGILGDTAARTALINARSQVQEYSRPYDDYCDLLDLCDLIGKGVASPAVKTACAKVKDAAAAAIVAAGYKGTGVDNSGGISIYFPKRKLSPLYKTLDFTKKTAWDEFLAAYLAGLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WL9</accession>
    <name>Q39WL9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1115</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513771.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1115"/>
    <dbReference type="EnsemblBacteria" id="ABB31355">
        <property type="protein sequence ID" value="ABB31355"/>
        <property type="gene ID" value="Gmet_1115"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1115"/>
    <dbReference type="eggNOG" id="COG4403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104584_2_0_7"/>
    <dbReference type="OMA" id="PVPWPCE"/>
    <dbReference type="OrthoDB" id="1318547at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="183" mass="20790" checksum="4BBC4DC31B753450" modified="2005-11-22" version="1">MNNELRDELLSMQHEDQKTLQELIDSGELGTVEYHPTIKDVHERNNKRIKEIIGQQGWPGISLVGKEAAEAAWLIVQHAVLDTVFMESCLAHLREAVKRGEAEGSHLAYLQDRVLTMSWKPQIYGTQHDVDESGTAFPLPMENPVEVDSLRREMGLGTLAEATRRIQERVNAIRRNRKANQAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WM7</accession>
    <name>Q39WM7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513763.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1107"/>
    <dbReference type="EnsemblBacteria" id="ABB31347">
        <property type="protein sequence ID" value="ABB31347"/>
        <property type="gene ID" value="Gmet_1107"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1107"/>
    <dbReference type="eggNOG" id="COG2844">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1426777_0_0_7"/>
    <dbReference type="OMA" id="THTMLAM"/>
    <dbReference type="OrthoDB" id="1735876at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="75"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="202" mass="22238" checksum="88855BABF5BF4FED" modified="2005-11-22" version="1">MTAGGLHNGSGGMESARHCRELVERWLADGSFDARLPEVVRLRGVLQPEQYHAEGDAWTHTMLAMEAVPDDADPRVFWGVLLHDIGKAETTAFIKGRWRSWGHAEAGAGEVSAIMTRLGFPHLAADVTWLVKHHTFHFSWNLTPGARLSPKQRRFMEHPLFPLLLEVCDADAAGSRGGSDKGVKIGQLADMYADVTKGWADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WP4</accession>
    <name>Q39WP4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1090"/>
    <dbReference type="EnsemblBacteria" id="ABB31330">
        <property type="protein sequence ID" value="ABB31330"/>
        <property type="gene ID" value="Gmet_1090"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1090"/>
    <dbReference type="eggNOG" id="COG1877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1068564_0_0_7"/>
    <dbReference type="OMA" id="CAGSDAN"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="28527" checksum="A06F8B234E4126CF" modified="2005-11-22" version="1">MNDSSQRLWIFSFDGVLTTAGTDRTRARLHRLTRQLLEELAGTPGERVAVLSSRSLEDLVSRVAIPGVFLGGGCGTEWHIPGGDSMTLSGRPKDLLMEKRDILLPVLRDLAELPGVTFEDRRWSAVFHVAGAAPKTKRTLDDRLQEACRDGRGALYRYPDMVEALFLPEITMEFGVRALCHLLRHEGAIICAGSDANDATALGWVVRQGGTAFSVGRRPLVSGSTAVVDLRSLVRQVRDLAGTSPPLPARWPERRYNKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WY7</accession>
    <name>Q39WY7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VacJ family lipoprotein fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MlaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514688.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0995"/>
    <dbReference type="EnsemblBacteria" id="ABB31237">
        <property type="protein sequence ID" value="ABB31237"/>
        <property type="gene ID" value="Gmet_0995"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0995"/>
    <dbReference type="eggNOG" id="COG2853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_372042_0_0_7"/>
    <dbReference type="OrthoDB" id="801235at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007428">
        <property type="entry name" value="MlaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30035">
        <property type="entry name" value="PTHR30035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04333">
        <property type="entry name" value="MlaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01805">
        <property type="entry name" value="VACJLIPOPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="747" mass="83092" checksum="34F6248133A4B38F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X38</accession>
    <name>Q39X38_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase, HDOD domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514427.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0944"/>
    <dbReference type="EnsemblBacteria" id="ABB31186">
        <property type="protein sequence ID" value="ABB31186"/>
        <property type="gene ID" value="Gmet_0944"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0944"/>
    <dbReference type="eggNOG" id="COG1639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048246_4_2_7"/>
    <dbReference type="OMA" id="DKVMDEM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="18"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="284" mass="31491" checksum="E9CC8BF003DFFFD8" modified="2005-11-22" version="1">MGSKRDKILDIIRDTNSLPTLPGVVSRLQALAENRKSSIEEMARLVSSDQILSARVLRLVNSPSYGFYRVSTISNALILLGVNVIKSLALSSSIFEIMEKTIVGLWEHSLGAGVAANIIARHLKLPEVEEISTAALLHDIGKVIIKEKCAEDYERICNMVERDGIPMLEAERQVLQTNHAEVGEWLVHNWYLPNKLSEPVACHHDVANAQHHKMKTAVVHLADVLVKASGFGFSGEVYVPRIQPTAWEWLGMAEDDLAAIVEELEDRLVEVKNFSLEIQSADGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X61</accession>
    <name>Q39X61_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0921</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513951.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0921"/>
    <dbReference type="EnsemblBacteria" id="ABB31163">
        <property type="protein sequence ID" value="ABB31163"/>
        <property type="gene ID" value="Gmet_0921"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0921"/>
    <dbReference type="eggNOG" id="COG1899">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879292_0_0_7"/>
    <dbReference type="OMA" id="TANFDMQ"/>
    <dbReference type="OrthoDB" id="1015407at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="315" mass="33346" checksum="4FE29CA34C459A5A" modified="2005-11-22" version="1">MKYRPVDLSGVSTYPLAERKNKVSIKNDFAGPVSAGMSVADLMGSLPRQLGGEALIGVADAVADARAKGKPVILAMGAHVIKCGLQPVLKTLIEAGAITAVALNGAGSIHDYELSLIGETSEDVGAVLHCGTFGMAEETGRDINRALKEGIARGMGYGESVGRFIIDNGNPFREWSLLATCVERDIPVTVHVALGTDIIHQHPAADGAVIGEATFRDFRLLTSVVADLGDGGVYLNVGSAVLLPEVFLKALSIAQNLGHHVDHFSTANFDMQQHYRPLQNVVKRPTSGKGRGYTVTGHHEIMLPLLAAAILDRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X70</accession>
    <name>Q39X70_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513942.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0912"/>
    <dbReference type="EnsemblBacteria" id="ABB31154">
        <property type="protein sequence ID" value="ABB31154"/>
        <property type="gene ID" value="Gmet_0912"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0912"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141296_0_0_7"/>
    <dbReference type="OMA" id="TCYRCHD"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223479" evidence="1">
        <location>
            <begin position="24"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="228" mass="25389" checksum="4DD5E0B38F01B037" modified="2005-11-22" version="1">MKKWLIALLLLAASTFSVQMALADKMSHKEYASTPIADCNSCHKGEGVAPNHDTDWLRGHRVLAGKAGSNCYQCHTQQFCLDCHKGGGIDAKLSTRNYQRDYVPKSHRTDFISIHPIKALDNPQSCNRCHEPSYCNECHSRFPKGSLRIKSHLRSGTTQTFIWNSEHATEARRNLQSCQTCHPDGDVCLKCHATSGKGGTGISPHPRNFKGGNIIDRSDRSCRKCHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XA1</accession>
    <name>Q39XA1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513028.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0881"/>
    <dbReference type="EnsemblBacteria" id="ABB31123">
        <property type="protein sequence ID" value="ABB31123"/>
        <property type="gene ID" value="Gmet_0881"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0881"/>
    <dbReference type="eggNOG" id="COG1723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011220_2_1_7"/>
    <dbReference type="OMA" id="HIMVLDK"/>
    <dbReference type="OrthoDB" id="1450477at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="2">
        <location>
            <begin position="54"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="274" mass="31647" checksum="9410387FC69E169B" modified="2005-11-22" version="1">MIDFAAYALSGELDLNRLAGSLGFPRRYRWEEPMVLDLTSLRPLPGDMGETKRVYLYYFGGVVFVNCTEEEIGSFFWSMGHHGEAFKEYPAVRYRDEYSLKRGEGERVEVTNDVATMPGYDPAYVDTICFVIAKSVALERIEERVDQVLDEMETIIALLDRGKLGISDRRLAKLAANVLTYKYQSISHIMVLEKPEFTWENPVADRLYLTMANIFELNQRYNEIKHKGETLLDITGVFTSLAHARRASRLEWIIIILIFIEIVIYIFELMRKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XB2</accession>
    <name>Q39XB2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.30</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cysE</name>
        <name evidence="7" type="ordered locus">Gmet_0870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>acetyl-CoA + L-serine = CoA + O-acetyl-L-serine</text>
            <dbReference type="Rhea" id="RHEA:24560"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.3.1.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.30" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513016.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0870"/>
    <dbReference type="EnsemblBacteria" id="ABB31112">
        <property type="protein sequence ID" value="ABB31112"/>
        <property type="gene ID" value="Gmet_0870"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0870"/>
    <dbReference type="eggNOG" id="COG1045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051638_10_0_7"/>
    <dbReference type="OMA" id="GDDVMLY"/>
    <dbReference type="OrthoDB" id="1639008at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009001">
        <property type="term" value="F:serine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03354">
        <property type="entry name" value="LbH_SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045304">
        <property type="entry name" value="LbH_SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042122">
        <property type="entry name" value="Ser_AcTrfase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005881">
        <property type="entry name" value="Ser_O-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000441">
        <property type="entry name" value="CysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01172">
        <property type="entry name" value="cysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="225" mass="24862" checksum="40EADEBFF16A1B41" modified="2005-11-22" version="1">MFARLHEDIQSVKERDPAARSSVEVFFCYPGLHAIWFHRFAHWFWMREFFFLGRFLSHIGRFFTGIEIHPGATIGRRLFIDHGMGVVIGETAEIGDDVTIYHGVTLGGVSLEKKKRHPTVDNNAVIGSGAKVLGPFTVGVGAKIGSNSVVVKEVPANATVVGIPGRVVMAADEPAKKADFEHGKLPDPEAKAISCLFDQLRELERKYADLADEHAALRRRVESGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XC9</accession>
    <name>Q39XC9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Sec translocon accessory complex subunit YajC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 11" type="primary">yajC</name>
        <name evidence="11" type="ordered locus">Gmet_0853</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the YajC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512998.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0853"/>
    <dbReference type="EnsemblBacteria" id="ABB31095">
        <property type="protein sequence ID" value="ABB31095"/>
        <property type="gene ID" value="Gmet_0853"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0853"/>
    <dbReference type="eggNOG" id="COG1862">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116157_2_0_7"/>
    <dbReference type="OMA" id="GMEMIIM"/>
    <dbReference type="OrthoDB" id="2082059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003849">
        <property type="entry name" value="Preprotein_translocase_YajC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33909">
        <property type="entry name" value="PTHR33909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02699">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01853">
        <property type="entry name" value="YAJCTRNLCASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01323">
        <property type="entry name" value="YajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00739">
        <property type="entry name" value="yajC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="106" mass="11147" checksum="F1FF31E60B3F91D8" modified="2005-11-22" version="1">MFGVAFAMAAQPGGAQPGGAMGAFQAILPLVFMFAIFYFLLIRPQQKKAKDHRTLLDSLKKGDQVVTAGGIHGKVGAIDGDVVLLEIASGVTIKISKGYIATLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XE8</accession>
    <name>Q39XE8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemerythrin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0834</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hemerythrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31076.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512978.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0834"/>
    <dbReference type="EnsemblBacteria" id="ABB31076">
        <property type="protein sequence ID" value="ABB31076"/>
        <property type="gene ID" value="Gmet_0834"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0834"/>
    <dbReference type="eggNOG" id="COG2703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086902_3_1_7"/>
    <dbReference type="OMA" id="WLVQHIS"/>
    <dbReference type="OrthoDB" id="1991725at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12107">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035938">
        <property type="entry name" value="Hemerythrin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012827">
        <property type="entry name" value="Hemerythrin_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47188">
        <property type="entry name" value="SSF47188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02481">
        <property type="entry name" value="hemeryth_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="9"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31076.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="136" mass="15889" checksum="8FC71B0508459367" modified="2012-10-31" version="2">MWTDDLAVGIDEIDSQHKALFEQLDKLLDACVAGGEREEVVTMLCFLDQYVVAHFSAEEKLQQEYGYPGYEKHRAEHEEFMRRINRFVEEVAAAAPTRDLVLRVNQTLIDWLKFHILAVDKEMSEFLLKKMRCNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XF1</accession>
    <name>Q39XF1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512975.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0831"/>
    <dbReference type="EnsemblBacteria" id="ABB31073">
        <property type="protein sequence ID" value="ABB31073"/>
        <property type="gene ID" value="Gmet_0831"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0831"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_369971_0_0_7"/>
    <dbReference type="OMA" id="RCISAKN"/>
    <dbReference type="OrthoDB" id="1881760at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="690" mass="73315" checksum="2C330F3E8EEC3068" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XK5</accession>
    <name>Q39XK5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Gmet_0777</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513522.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0777"/>
    <dbReference type="EnsemblBacteria" id="ABB31019">
        <property type="protein sequence ID" value="ABB31019"/>
        <property type="gene ID" value="Gmet_0777"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0777"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019564_0_1_7"/>
    <dbReference type="OMA" id="SKFARMP"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017232">
        <property type="entry name" value="NtrY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045671">
        <property type="entry name" value="NtrY-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19312">
        <property type="entry name" value="NtrY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037532">
        <property type="entry name" value="STHK_NtrY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="334"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="405"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="536"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="748" mass="84496" checksum="52B51AA112FCA4F9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XQ8</accession>
    <name>Q39XQ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease Z-related hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0724</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365716.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0724"/>
    <dbReference type="EnsemblBacteria" id="ABB30966">
        <property type="protein sequence ID" value="ABB30966"/>
        <property type="gene ID" value="Gmet_0724"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0724"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823444_0_0_7"/>
    <dbReference type="OMA" id="HIDHFIG"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="39"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="242"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="356" mass="40851" checksum="4A62099AF18FD026" modified="2005-11-22" version="1">MPPLFHPTPVNGPFDDPGVYVDFLFERRAILFDLGDITPLPPRKVLRISDIFVSHTHVDHFIGFDRVVRLCLGREKRLRLYGPPGFTDQVAHRLAGYTWNLVESYPTDFTVEATELAPGGGVRTVEFHCRREFVPENESWEQISNGVILDEETFRVRAAFLDHGTPCLAFALEEKLHVNVRKNRLEEMGLPTGEWLRELKNAILRGERDDLPFRVWWREGGQVREKIHPLGELRERLVGIVPGQRVVYVTDAGLTPENGSRIVELAREADYLFIETTFLHAEEERARERSHLTARQAGELAREAGVARVVPFHFSPKYRGMEEMLRTELEEAFFSEKTPGTRSNRVLSQQISAEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XR1</accession>
    <name>Q39XR1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0721</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514626.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0721"/>
    <dbReference type="EnsemblBacteria" id="ABB30963">
        <property type="protein sequence ID" value="ABB30963"/>
        <property type="gene ID" value="Gmet_0721"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0721"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_747545_0_0_7"/>
    <dbReference type="OMA" id="ILRVMVY"/>
    <dbReference type="OrthoDB" id="401909at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="360" mass="40150" checksum="2641554B9E4E2F57" modified="2005-11-22" version="1">MNDELRRHYERWVYPRYPLLASVRPWDTYALNLDTLHARFNGALPSSHARRILLAGCGSFSPYPTSLANPGVPITALDLSAANLRRARLHCLVHGRFGVDFERGDILDPAAASGEYGFIDSFGVIHHLPDPLEGLRALERRLAPGGILRLMVYSRGGRREAESIRTALRILKIGDVATVKRLIRRAPAGSRFRRYVDASSEAAFDAGIADAFLHPRTRTYRIDELMALVAETGLTPLMLAHDSALPSMSEEMARLRRLEREGEETPNFILYLGRQPLGECGLSPDARLMLNPALRTAVGPLRLAPIVIPPRLGRPNSPLGFAEKRFLRRFISPVPVASLAPEERERARPFLDALFLVAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XR9</accession>
    <name>Q39XR9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0713</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514618.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0713"/>
    <dbReference type="EnsemblBacteria" id="ABB30955">
        <property type="protein sequence ID" value="ABB30955"/>
        <property type="gene ID" value="Gmet_0713"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0713"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_64_7"/>
    <dbReference type="OMA" id="MEYKVEY"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033425">
        <property type="entry name" value="MASE3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17159">
        <property type="entry name" value="MASE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="259"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="429"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="385"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="639" mass="71084" checksum="8FDB75466F197536" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XW9</accession>
    <name>Q39XW9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nitrogenase protein alpha chain</fullName>
            <ecNumber evidence="10">1.18.6.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nifD</name>
        <name evidence="12" type="ordered locus">Gmet_0663</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>16 ATP + 16 H2O + N2 + 8 reduced [2Fe-2S]-[ferredoxin] = 16 ADP + 6 H(+) + H2 + 2 NH4(+) + 8 oxidized [2Fe-2S]-[ferredoxin] + 16 phosphate</text>
            <dbReference type="Rhea" id="RHEA:21448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17997"/>
            <dbReference type="ChEBI" id="CHEBI:18276"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="1.18.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[7Fe-Mo-9S-C-homocitryl] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30409"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[8Fe-7S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21143"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Tetramer of two alpha and two beta chains. Forms complex with the iron protein (nitrogenase component 2).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the NifD/NifK/NifE/NifN family.</text>
    </comment>
    <dbReference type="EC" id="1.18.6.1" evidence="10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514271.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0663"/>
    <dbReference type="EnsemblBacteria" id="ABB30905">
        <property type="protein sequence ID" value="ABB30905"/>
        <property type="gene ID" value="Gmet_0663"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0663"/>
    <dbReference type="eggNOG" id="COG2710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025876_1_1_7"/>
    <dbReference type="OMA" id="CGQYSWA"/>
    <dbReference type="OrthoDB" id="363662at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016612">
        <property type="term" value="C:molybdenum-iron nitrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018697">
        <property type="term" value="F:carbonyl sulfide nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016163">
        <property type="term" value="F:nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01976">
        <property type="entry name" value="Nitrogenase_MoFe_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000510">
        <property type="entry name" value="Nase/OxRdtase_comp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010143">
        <property type="entry name" value="Nase_comp1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000318">
        <property type="entry name" value="Nase_comp1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005972">
        <property type="entry name" value="Nase_Mo-Fe_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43457">
        <property type="entry name" value="PTHR43457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00148">
        <property type="entry name" value="Oxidored_nitro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01862">
        <property type="entry name" value="N2-ase-Ialpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01282">
        <property type="entry name" value="nifD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00699">
        <property type="entry name" value="NITROGENASE_1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00090">
        <property type="entry name" value="NITROGENASE_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="8 9" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_nitro" evidence="11">
        <location>
            <begin position="67"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB30905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="481" mass="53764" checksum="21810EFD0E0F8879" modified="2005-11-22" version="1">MSKAIRNIDGITKASTQEMIDKVLEVYPEKGRKKRAPHLAPNDQASCSACVKSNKKTVPGVMSARGCAYAGAKGVVWGPIRDMVHVSHGPVGCGWYSWGTRRNLMSGKLGVDQFGMQFTSDFQEKDIVYGGDKKLKVLLKEAKELFPLAKGISVLSECPVGLIGDDINAVAKTSAKELDIPIIPCNCEGFRGVSQSLGHHISNDTIRDYIIETREFAEPVGPYDIALIGEYNIGGDAWSTKPLLEECGFNVKAVWTGDGEMEKIAATHQVRLNVIHCYRSMNYMCKVMEEKYGIPWIELNFFGPTKIRESLRKLAELFDDTIKEKVEAVIAKYDPQMQAVIEEVRPRLEGKKVMLYVGGLRPRHTIGAYEDLGMLCVGSGYEFAHTDDYDRTAPEMPDATVVYDDASELEMEQFAHVLKPDLVASGIKEKYVFQKMGLPFRQMHSWDYSGPYHGYKGFPIFARDIDMAINSPTWNLVRSPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XX4</accession>
    <name>Q39XX4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF-N1</name>
        <name evidence="5" type="ordered locus">Gmet_0658</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514266.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0658"/>
    <dbReference type="EnsemblBacteria" id="ABB30900">
        <property type="protein sequence ID" value="ABB30900"/>
        <property type="gene ID" value="Gmet_0658"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0658"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="TQRFSYW"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="308" mass="33561" checksum="DEC7FBED4463F46C" modified="2005-11-22" version="1">MDAIITDNLTKRFGTLTAVGGLTLSVAQGELFGLVGSDGAGKTTTMRMLTGIMDPTEGAARVMGRHTVREAEPLKEEIGYMSQRFGLYPDLTVLENLHFYADIYGLPWRGRDEKISRLLSFSNLTPFGKRLAGNLSGGMKQKLGLACALIHTPKVLFLDEPTNGVDPVSRRDFWRILYQLLREGVTVFVATAYLDEADRCNRVGLIHRGRLLACDTPDNLRGLMDGTILEVLTPAPRRAALLLRERLEGESVGIFGDRLHVVTRDAAEAGPAIKAIMEGAGVTVQSIRPIEPSLEDVLVSVLSGEATQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y22</accession>
    <name>Q39Y22_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UPF0313 protein Gmet_0609</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0609</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UPF0313 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365694.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0609"/>
    <dbReference type="EnsemblBacteria" id="ABB30852">
        <property type="protein sequence ID" value="ABB30852"/>
        <property type="gene ID" value="Gmet_0609"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0609"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018288_2_0_7"/>
    <dbReference type="OMA" id="TCMYYTG"/>
    <dbReference type="OrthoDB" id="229299at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01251">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022946">
        <property type="entry name" value="UPF0313"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024560">
        <property type="entry name" value="UPF0313_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013704">
        <property type="entry name" value="UPF0313_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32331">
        <property type="entry name" value="PTHR32331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11842">
        <property type="entry name" value="DUF3362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08497">
        <property type="entry name" value="Radical_SAM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01069">
        <property type="entry name" value="UPF0313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03904">
        <property type="entry name" value="SAM_YgiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="289"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="583"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="603" mass="67561" checksum="E2C8421719655039" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y30</accession>
    <name>Q39Y30_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514731.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0601"/>
    <dbReference type="EnsemblBacteria" id="ABB30844">
        <property type="protein sequence ID" value="ABB30844"/>
        <property type="gene ID" value="Gmet_0601"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0601"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_768951_0_0_7"/>
    <dbReference type="OrthoDB" id="1853490at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3820.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038266">
        <property type="entry name" value="NapC/NirT_cytc_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223284" evidence="1">
        <location>
            <begin position="21"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="349" mass="36966" checksum="45C735E1B39ED353" modified="2005-11-22" version="1">MKRIGITFIALLALAAPAMAGHVATIGTGTCGSCHRTNLVTQHGGFVATVCQTCHDSTVAAVKDTIATGVAGQPYTCSNCHGAETHLSKHGDYAANFAAYNGVEPVTSGIWTAPSSYTKVTPATKEYQVCVKCHSSNGLGSTTNSVSGVTGPSGLLLTDQAMEFSQYNRSGHPIVTGLNNYPNSPAPKALVKTQLSSPWNVNMGKQTMKCFDCHGADGKLVGVGRDWPYNSATGQLWKLGDASNSKLFCKNCHPLVNTNNTHSESNHSKYPCVYCHTRVPHGGKVSRLIVTFTSGLPSRYYPDGKGGGTPSLQDKLLRYTKATSASRYDTPSCDADCHGSHQNTTGEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YC1</accession>
    <name>Q39YC1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30753.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512206.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0510"/>
    <dbReference type="EnsemblBacteria" id="ABB30753">
        <property type="protein sequence ID" value="ABB30753"/>
        <property type="gene ID" value="Gmet_0510"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0510"/>
    <dbReference type="HOGENOM" id="CLU_2493474_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30753.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="86" mass="8939" checksum="D3EBCD66C858D1C8" modified="2012-10-31" version="2">MKTLGFGFAVLLIVLLVILSVASYALPVAAPETGEYGLLAGGLLGFASLIITLKLIPGIIRFASIIEEEEVRRPEETAVAPGKSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YF5</accession>
    <name>Q39YF5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sirohydrochlorin cobaltochelatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbiX</name>
        <name evidence="3" type="ordered locus">Gmet_0476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30719.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513845.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0476"/>
    <dbReference type="DNASU" id="3739843"/>
    <dbReference type="EnsemblBacteria" id="ABB30719">
        <property type="protein sequence ID" value="ABB30719"/>
        <property type="gene ID" value="Gmet_0476"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0476"/>
    <dbReference type="eggNOG" id="COG2138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065901_2_0_7"/>
    <dbReference type="OMA" id="WREPFER"/>
    <dbReference type="OrthoDB" id="1573073at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002762">
        <property type="entry name" value="CbiX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01903">
        <property type="entry name" value="CbiX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30719.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="127" mass="14223" checksum="9553F0253372A589" modified="2012-10-31" version="2">MKTAILLMAHGSRIAEANNAVREIAAMVKEMTGYDIVEVSFREQHLPNIQEGIDACVAKGARRVLLMPYFLFVGAHVQEDLPEEMAQARERYPKVEFAMGPHLGVHRKLAEVEVERIAEALTATGWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YF9</accession>
    <name>Q39YF9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cobalt transport protein CbiM</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Energy-coupling factor transporter probable substrate-capture protein CbiM</fullName>
            <shortName evidence="11">ECF transporter S component CbiM</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11 12" type="primary">cbiM</name>
        <name evidence="12" type="ordered locus">Gmet_0472</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cell inner membrane</location>
            <topology evidence="11">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CbiM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0472"/>
    <dbReference type="EnsemblBacteria" id="ABB30715">
        <property type="protein sequence ID" value="ABB30715"/>
        <property type="gene ID" value="Gmet_0472"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0472"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_3_0_7"/>
    <dbReference type="OMA" id="GTCSHPC"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01462">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018024">
        <property type="entry name" value="CbiM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43627">
        <property type="entry name" value="PTHR43627"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00123">
        <property type="entry name" value="cbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 11" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2 11" id="KW-0171">Cobalt transport</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019133" description="Cobalt transport protein CbiM" evidence="11">
        <location>
            <begin position="21"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB30715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="245" mass="25504" checksum="213BE3763E1B0CC9" modified="2005-11-22" version="1" precursor="true">MKTVLFIGCVLLIMASPAHAMHISEGILPFGWAALWFAVAVPFLAVGLRRLNELSRDDLSMKPLVGLMAAVVFIISCMPIPVPSAGTCSHPCGTGISAILVGPFVSVAIAAVALLIQALLLAHGGLSTLGADIVSMGVVGSFAGWFVFQGMRRVRASLAVAGFAAGLLADWATYLATSGELAAGIRGSEPFIPLFLKIAVAFIPTQLPLGILEGAMTAGMVVLLSRKRPDLLVKMRVLRAEEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YL4</accession>
    <name>Q39YL4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Cell division protein FtsZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">ftsZ</name>
        <name evidence="9" type="ordered locus">Gmet_0417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Assembles at midcell at the inner surface of the cytoplasmic membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the FtsZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512389.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0417"/>
    <dbReference type="EnsemblBacteria" id="ABB30660">
        <property type="protein sequence ID" value="ABB30660"/>
        <property type="gene ID" value="Gmet_0417"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0417"/>
    <dbReference type="eggNOG" id="COG0206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024865_0_1_7"/>
    <dbReference type="OMA" id="GNPSIGQ"/>
    <dbReference type="OrthoDB" id="1009041at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051258">
        <property type="term" value="P:protein polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02201">
        <property type="entry name" value="FtsZ_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00909">
        <property type="entry name" value="FtsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000158">
        <property type="entry name" value="Cell_div_FtsZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020805">
        <property type="entry name" value="Cell_div_FtsZ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045061">
        <property type="entry name" value="FtsZ/CetZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024757">
        <property type="entry name" value="FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30314">
        <property type="entry name" value="PTHR30314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12327">
        <property type="entry name" value="FtsZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00423">
        <property type="entry name" value="CELLDVISFTSZ"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="SSF52490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="SSF55307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00065">
        <property type="entry name" value="ftsZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01134">
        <property type="entry name" value="FTSZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01135">
        <property type="entry name" value="FTSZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 5 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0717">Septation</keyword>
    <feature type="domain" description="Tubulin" evidence="7">
        <location>
            <begin position="13"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin_C" evidence="8">
        <location>
            <begin position="207"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="384" mass="41008" checksum="D0BF20AFF8A0A8C3" modified="2005-11-22" version="1">MFEFDESIDQCAKIKVIGVGGSGGNAVNTMIESQVGGVDFAVANTDVQALRISKAPIKIQIGRQLTKGLGAGADPCRGREAALEDREQLAETLKGADMIFIAAGMGGGTGTGAAPIIAEVAKEAGALTVGVVTKPFSREGKQRLAKADDGIKELKKHVDSLIVIPNDRLIGLAGKSMSILDAFKPSDDVLRQAVQGISDLITTSGFINVDFADVKAIMSERGMAMMGIGIAAGENRAVEAALRAISSPLLEDVDISGAKGVLVNISGSASMTMDEFEAVNRTIHEKVHEDANIIIGVTIDETLGDQLKVTAIATGFGDRFDVEKQRQELKTVTPLGGRQEVNREIPTFIREKQQREPSYNRQKGFFSDEEDQYDIPTFLRKSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YM5</accession>
    <name>Q39YM5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan transglycosylase and transpeptidase FtsI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ftsI</name>
        <name evidence="3" type="ordered locus">Gmet_0406</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512378.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0406"/>
    <dbReference type="EnsemblBacteria" id="ABB30649">
        <property type="protein sequence ID" value="ABB30649"/>
        <property type="gene ID" value="Gmet_0406"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0406"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_6_2_7"/>
    <dbReference type="OMA" id="HGKEEYY"/>
    <dbReference type="OrthoDB" id="213680at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PASTA" evidence="2">
        <location>
            <begin position="596"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="657" mass="71183" checksum="D9398AF087948039" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YN6</accession>
    <name>Q39YN6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor RpoD</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Sigma-70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">rpoD</name>
        <name evidence="10" type="ordered locus">Gmet_0395</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts transiently with the RNA polymerase catalytic core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family. RpoD/SigA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512367.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0395"/>
    <dbReference type="EnsemblBacteria" id="ABB30638">
        <property type="protein sequence ID" value="ABB30638"/>
        <property type="gene ID" value="Gmet_0395"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0395"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_7_2_7"/>
    <dbReference type="OMA" id="IYAYKDA"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00963">
        <property type="entry name" value="Sigma70_RpoD_SigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007127">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042189">
        <property type="entry name" value="RNA_pol_sigma_70_r1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012760">
        <property type="entry name" value="RNA_pol_sigma_RpoD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028630">
        <property type="entry name" value="Sigma70_RpoD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03979">
        <property type="entry name" value="Sigma70_r1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02393">
        <property type="entry name" value="RpoD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="9">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="6">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-2" evidence="6">
        <location>
            <begin position="346"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-3" evidence="6">
        <location>
            <begin position="425"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Sigma-70 factor domain-4" evidence="6">
        <location>
            <begin position="514"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="248"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Interaction with polymerase core subunit RpoC" evidence="6">
        <location>
            <begin position="370"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="579" mass="65916" checksum="5B75F83A400414BF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YP9</accession>
    <name>MURA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylglucosamine 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Enoylpyruvate transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylglucosamine enolpyruvyl transferase</fullName>
            <shortName evidence="1">EPT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murA</name>
        <name type="ordered locus">Gmet_0382</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:18681"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="EC" id="2.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPSP synthase family. MurA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30625.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512354.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YP9"/>
    <dbReference type="SMR" id="Q39YP9"/>
    <dbReference type="STRING" id="269799.Gmet_0382"/>
    <dbReference type="EnsemblBacteria" id="ABB30625">
        <property type="protein sequence ID" value="ABB30625"/>
        <property type="gene ID" value="Gmet_0382"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0382"/>
    <dbReference type="eggNOG" id="COG0766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027387_0_0_7"/>
    <dbReference type="OMA" id="CDPHRAT"/>
    <dbReference type="OrthoDB" id="537477at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008760">
        <property type="term" value="F:UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019277">
        <property type="term" value="P:UDP-N-acetylgalactosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01555">
        <property type="entry name" value="UdpNAET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00111">
        <property type="entry name" value="MurA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005750">
        <property type="entry name" value="UDP_GlcNAc_COvinyl_MurA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01072">
        <property type="entry name" value="murA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-0670">Pyruvate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000231207" description="UDP-N-acetylglucosamine 1-carboxyvinyltransferase">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="2-(S-cysteinyl)pyruvic acid O-phosphothioketal" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00111"/>
        </source>
    </evidence>
    <sequence length="417" mass="44607" checksum="21E60C0CB0BA6003" modified="2006-04-04" version="2">MDKLIIKGGKKLTGDVSVSGSKNAALPVFISTILAPGLNEIRNVPFLRDINTTIKVLESLGAVVEGNGNIVKIDTTHVNDVEATYDLVKTMRASVLVLGPLLARHGRARVSLPGGCAIGARPINLHLKGLAALGADIRLEHGYVEAKAKKLKGARINFDIATVGGTEQLMMAAALAKGETILENAAREPEIIDLADILNRMGARIDGAGTDTIRIIGVKELAPVVHDVMPDRIEAGTFMVAAAITGGDIKIHNMKLEHLDALVFKLQDAGVEIINRDNVVRVKGPRRPRAINIKTRPYPGFPTDMQAQFMALMCVADGASVISENIFENRFMHVSELLRFGADITIEGNTATVKGVKKLSGAPVMATDLRASASLILAGLAADNTTEISRIYHLDRGYDSIEKKLAGLGADIKRVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YV3</accession>
    <name>Q39YV3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Respiratory nitrate reductase, cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">narC-1</name>
        <name evidence="8" type="ordered locus">Gmet_0328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512300.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0328"/>
    <dbReference type="EnsemblBacteria" id="ABB30571">
        <property type="protein sequence ID" value="ABB30571"/>
        <property type="gene ID" value="Gmet_0328"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0328"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073827_0_0_7"/>
    <dbReference type="OMA" id="ERRDEAW"/>
    <dbReference type="OrthoDB" id="1469969at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223526" evidence="6">
        <location>
            <begin position="26"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="25"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="262" mass="27748" checksum="E4F0F579C0D4B9F2" modified="2005-11-22" version="1">MARGILRAAVSRVCLVLVLSLAAHAYGDPGKDLFDKQCSGCHTVGGGDSGGPDLKGVTDRRSEEWLESIIIEPDKLAATDPARKELIKKYGYEMPKLGIGHDDAIKIITWLRGGGGGAQTGSPPADEHPEVVVTPALVAKGKAFFTGQKPLANGGAPCIACHRISTPGITGGNLAVSNLSASYQKMGEKGMRGALKALKFPTMKKIYENRPLTDDEVTSLIALYKDAALTKSTPSASFFPAYGAGTFVVFLVGLTLYKRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YY9</accession>
    <name>Q39YY9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514001.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0290"/>
    <dbReference type="ESTHER" id="geomg-q39yy9">
        <property type="family name" value="PGAP1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30535">
        <property type="protein sequence ID" value="ABB30535"/>
        <property type="gene ID" value="Gmet_0290"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0290"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025560_0_0_7"/>
    <dbReference type="OrthoDB" id="606679at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="685" mass="75710" checksum="44E79A74AB234627" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z03</accession>
    <name>Q39Z03_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513593.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0276"/>
    <dbReference type="EnsemblBacteria" id="ABB30521">
        <property type="protein sequence ID" value="ABB30521"/>
        <property type="gene ID" value="Gmet_0276"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0276"/>
    <dbReference type="HOGENOM" id="CLU_1287288_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="214" mass="23437" checksum="4F59FA4C4830A746" modified="2005-11-22" version="1">MKCIWLVGLTIILLPFLAGPCDAFRKAEGSIPICKGPGCETVAVETPWPEAPSSDESITVLFGGGSFRVPSDVASVGIGDNLSVFRFKSGEPLLLSRETFSALKLPKRGLSVIEAANVLFTKTPKDPEPSGKDDRKSWRLMLSMKRGFFSTNPRLAVYRKGPVTIYQITEGPGPYRNVALVANAHSRNFLMRLESNCEDKKFIEVLSTISAKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z44</accession>
    <name>Q39Z44_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CvfB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513551.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0235"/>
    <dbReference type="DNASU" id="3739698"/>
    <dbReference type="EnsemblBacteria" id="ABB30480">
        <property type="protein sequence ID" value="ABB30480"/>
        <property type="gene ID" value="Gmet_0235"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0235"/>
    <dbReference type="eggNOG" id="COG2996">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064885_1_0_7"/>
    <dbReference type="OMA" id="GAFMDWG"/>
    <dbReference type="OrthoDB" id="1382881at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014464">
        <property type="entry name" value="CvfB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039566">
        <property type="entry name" value="CvfB_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040764">
        <property type="entry name" value="CvfB_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37296">
        <property type="entry name" value="PTHR37296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17783">
        <property type="entry name" value="CvfB_WH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13509">
        <property type="entry name" value="S1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF012524">
        <property type="entry name" value="YitL_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1_2" evidence="2">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="CvfB_WH" evidence="3">
        <location>
            <begin position="221"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR012524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="295" mass="32130" checksum="3E96FD1909D7ADED" modified="2005-11-22" version="1">MEYTEQPGLCRLHTLKVVRVDKQGVWLEAGGRLAHLPRREAPQSSPGDPVDVFLYQDGVGELQATCRLPLAQAGEFALLTVKSVGSHGAFLDWGLAKDLLAPYRLQPERMQVARSYLVKVDLDPQGRPFANARIDDCLDRGRPDLREGDAVDLLVWQFTDLGAKVIVNHRYPALLYRDELPAGAIVGMPLSGYVKRLREDGRLDVTLRKVGAEAVSDARDAILAALAAHGGTLPLHDRSSPAAIEKALGMSKKSFKKAVGGLYKDGLVTLNDEGIRLTGKGTANSQSPERDRPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZA3</accession>
    <name>Q39ZA3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512762.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0175"/>
    <dbReference type="DNASU" id="3739656"/>
    <dbReference type="EnsemblBacteria" id="ABB30421">
        <property type="protein sequence ID" value="ABB30421"/>
        <property type="gene ID" value="Gmet_0175"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0175"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_905402_0_0_7"/>
    <dbReference type="OMA" id="WKGHVII"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223336" evidence="1">
        <location>
            <begin position="24"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="299" mass="33205" checksum="42B69C6C51305F4E" modified="2005-11-22" version="1">MSRWLKAAAAAFLMLLSTTVARAGDAQHYAVAELPTPVLNTPDFPRVFGGQDGRTVKTDHQGQIRELEFIALPGAAFTVQETLRRGGSVVHRVTTDDYPYPTTTGYFVDARFVRLTDETPHPRARKLPSRNKIITRLLAARGSRYVWGGNVRAGVPDMIRLFPPAGKLSAETERRWLLQGLDCSGLLYEATDGVTPRNTSALAGYGRGVPIAGLSTEEIRQQLEPLDLIVWKGHVIIVLDRERTIESRLGPVPGKRDGVAVRPLRDVLSEVMGKRVPVDRFAEKNGRGEKTFVVRRWYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZC6</accession>
    <name>Q39ZC6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acetate kinase</fullName>
            <ecNumber evidence="6">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ackA</name>
        <name evidence="8" type="ordered locus">Gmet_0149</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512734.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0149"/>
    <dbReference type="EnsemblBacteria" id="ABB30398">
        <property type="protein sequence ID" value="ABB30398"/>
        <property type="gene ID" value="Gmet_0149"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0149"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_7"/>
    <dbReference type="OMA" id="IHYLYSI"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="6">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="404" mass="44001" checksum="D3FA832D9162F146" modified="2005-11-22" version="1">MIILILNCRGFSIHFQLFDWSTRTILARGDVDRIELGDSFIVMEVPGRDPYHLDSDCSSFGAAVALILSTLTHPLEGPLDRVEQIAAVGHRVAHGGERFTSSVTINEEIIAAVRGFEELAPLHIPANLAGIEGAMATLPRTPHVAVFDSAFHQTMPLHAYIYPLPWEWYEKHGVRRYGFHGAPHCYAAQRGAALLGRDPAACNLVTVHIGNGTSLCAVEGGRSIDTSMGLTPLEGTMMGTRCGSIDPGIPPFMMQEEQLAPRDMDRILNQRSGAAGITGLKLDRAAFLARAAEGNERCLLALEMEAYRLKKHIGGYAAALGRLDAVVFSTASGEGEWLVREKTLADMEIFGIRLDRERNRAARSVEREERISADDSPVAVYVVHTEEEMVYAEEVAALLNGAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZE5</accession>
    <name>Q39ZE5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix transcriptional regulator, LexA-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514135.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0130"/>
    <dbReference type="EnsemblBacteria" id="ABB30379">
        <property type="protein sequence ID" value="ABB30379"/>
        <property type="gene ID" value="Gmet_0130"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0130"/>
    <dbReference type="eggNOG" id="COG1974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1419407_0_0_7"/>
    <dbReference type="OMA" id="MMDIGIM"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06529">
        <property type="entry name" value="S24_LexA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039418">
        <property type="entry name" value="LexA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12844">
        <property type="entry name" value="HTH_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="SSF51306"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="216" mass="23879" checksum="2A7039E614B030B6" modified="2005-11-22" version="1">MAVSPIVPTPSTGRRIKEIRINKGLTQKEFADSLGIVQGFLSGIEREKKTPSDTLLIALCNLYEISPSWLASGEGEMYRTPRRAGQPATSPGGEGIPLLERIGPEFPHRVGEDDIRDRVALPEVSEGCYAIVAYGDFMAPTIRDGDLVIFRPGEEPQNGEVVLVTNRWGEAILRRYRVRNGDIVYSPDNATYSPFTPAPETRIIGTVAEVWRKVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZN0</accession>
    <name>Q39ZN0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513811.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0044"/>
    <dbReference type="EnsemblBacteria" id="ABB30294">
        <property type="protein sequence ID" value="ABB30294"/>
        <property type="gene ID" value="Gmet_0044"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0044"/>
    <dbReference type="eggNOG" id="COG1499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114437_0_0_7"/>
    <dbReference type="OMA" id="HHGDLAI"/>
    <dbReference type="OrthoDB" id="1542462at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="172" mass="19035" checksum="FCE9B9C104D908B9" modified="2005-11-22" version="1">MTTPRGSARFGVEEHGKRAARSTDVYLPAEGKEEAVVCTGCKATFWGKRWFNEGDEGAKFPAGHLPHKGVCPACQRMKDNNPAGVVTLSGDYLLKHEEVILNAVKNVEAKARAKNPLARIMEIGQEANVLTIRTTDEKLAEKLGKEIYKSHSGKLGLQWSQDEGFVRVNWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PT0</accession>
    <name>Q39PT0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periplasmic energy transduction protein, TonB-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_3539</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513695.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3539"/>
    <dbReference type="EnsemblBacteria" id="ABB33744">
        <property type="protein sequence ID" value="ABB33744"/>
        <property type="gene ID" value="Gmet_3539"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3539"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076706_0_0_7"/>
    <dbReference type="OMA" id="TYVDMVT"/>
    <dbReference type="OrthoDB" id="1631916at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="251" mass="26699" checksum="BE17842E50A788AC" modified="2005-11-22" version="1">MSRTRQPRDTGLGWGVAASCVVHASVAAFVLLHHFSSPAPLEAPVYYVDVVNLPVAAPQAGSPVTGGSPPPAAPSPPPKPAEMALPQKRTPTKAATPKKSSSKESDAGKAFEERMDKLQRAIDERRQEAALDSLRRKTAGSGRQPERVGTPGGTGKEAGSDYASYIQSRLTDAFQSTIAHQSKAPEVVVKLTIDAGGHIARKRIERSSGDKIFEESVYKAIARAEKTFVPPPGGGEFDYGFIFRPQGVGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PV2</accession>
    <name>Q39PV2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbonic anhydrase, beta-family, clade B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">can</name>
        <name evidence="2" type="ordered locus">Gmet_3517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513674.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3517"/>
    <dbReference type="EnsemblBacteria" id="ABB33722">
        <property type="protein sequence ID" value="ABB33722"/>
        <property type="gene ID" value="Gmet_3517"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3517"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_5_3_7"/>
    <dbReference type="OMA" id="DRNASWS"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="211" mass="24024" checksum="F9ABB843037F509E" modified="2005-11-22" version="1">MITTLLEGNRRFVAETFEKEKELFVELTRGQKPTVLWIGCSDSRVPVNTITQTKAGEVFVHRNVGNIVAANDWNLSAVLEFSINHLKIPDIVICGHYGCGGIQALDEENSDDKYIPIWLINAYKAKERVDEKLRALHIDIPHEQRMKLIVEENVRLQLEHLREYPFVRRAVEEGKLTLNGWVYDMGNGEIRIVATESAPRIGKGTCSIKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PX2</accession>
    <name>Q39PX2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cation-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_3497</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513654.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3497"/>
    <dbReference type="EnsemblBacteria" id="ABB33702">
        <property type="protein sequence ID" value="ABB33702"/>
        <property type="gene ID" value="Gmet_3497"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3497"/>
    <dbReference type="eggNOG" id="COG0474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002360_6_4_7"/>
    <dbReference type="OMA" id="FTIFGWF"/>
    <dbReference type="OrthoDB" id="178322at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008553">
        <property type="term" value="F:P-type proton-exporting transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02076">
        <property type="entry name" value="P-type_ATPase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006534">
        <property type="entry name" value="P-type_ATPase_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01647">
        <property type="entry name" value="ATPase-IIIA_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="626"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="685"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="754"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="783"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Cation_ATPase_N" evidence="9">
        <location>
            <begin position="16"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="824" mass="88519" checksum="3C1498E527F988D4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q79</accession>
    <name>Q39Q79_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Winged-helix transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512609.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3383"/>
    <dbReference type="EnsemblBacteria" id="ABB33595">
        <property type="protein sequence ID" value="ABB33595"/>
        <property type="gene ID" value="Gmet_3383"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3383"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_7"/>
    <dbReference type="OMA" id="LWIDLIS"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="224" mass="26006" checksum="662ADC0E111849DA" modified="2005-11-22" version="1">MKILVVEDEKKVSSFIKRGLEEERYEVEAAFNGEDGLKMALEKGFDLIILDVMLPKKDGLSVVRELRERKNATPVLMLTAKDSVEDIVAGLDSGSDDYLTKPFAFAELLARVRALVRRSEQDRGAEIRFADLRLDPVTHKVWRKDKEIDLTAKEYSLLEYFMRNPNQVLTRTMIAEHVWDYTFDSFTNIIDVYVNYLRKKIDREADKKLIHTVRGVGYILKEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q89</accession>
    <name>Q39Q89_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein GspM, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gspM</name>
        <name evidence="2" type="ordered locus">Gmet_3373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512599.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3373"/>
    <dbReference type="EnsemblBacteria" id="ABB33585">
        <property type="protein sequence ID" value="ABB33585"/>
        <property type="gene ID" value="Gmet_3373"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3373"/>
    <dbReference type="HOGENOM" id="CLU_1487039_0_0_7"/>
    <dbReference type="OMA" id="TIALIKP"/>
    <dbReference type="OrthoDB" id="1762982at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="181" mass="20247" checksum="C05F7113442C9205" modified="2005-11-22" version="1">MTVFDRIRDAYGAMDSQTRLRWGYALIALLALAVAFSAIYDRIALLEKKRIRREADLVEMMGLKNNIRDVRAVSQRFTNRLAATRGDETPAKIVEETGIKGKSTRVAPMKGEERGGFLEDAAEVKIEGLTANEAVNLLHRLEKGTRPLIVKKALLRTRFDDPSRLDLTLTVALLRQAPGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QB3</accession>
    <name>Q39QB3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">NADH dehydrogenase I, G subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">nuoG-1</name>
        <name evidence="15" type="ordered locus">Gmet_3349</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512575.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3349"/>
    <dbReference type="EnsemblBacteria" id="ABB33561">
        <property type="protein sequence ID" value="ABB33561"/>
        <property type="gene ID" value="Gmet_3349"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3349"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_7"/>
    <dbReference type="OMA" id="MTNHEMI"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="11">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="79"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="177"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="216"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB33561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="828" mass="88975" checksum="175411711D286EB0" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QR9</accession>
    <name>Q39QR9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ribonuclease G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cafA</name>
        <name evidence="7" type="ordered locus">Gmet_3192</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366159.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3192"/>
    <dbReference type="EnsemblBacteria" id="ABB33405">
        <property type="protein sequence ID" value="ABB33405"/>
        <property type="gene ID" value="Gmet_3192"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3192"/>
    <dbReference type="eggNOG" id="COG1530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003468_5_3_7"/>
    <dbReference type="OMA" id="TKGPRIS"/>
    <dbReference type="OrthoDB" id="1209444at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1" evidence="6">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="500" mass="57173" checksum="8DD689F129667F19" modified="2005-11-22" version="1">MANELVINTSSHETRIALIENGTIAELYIERSREKGIVGNIYKGKVVRVLPGMQAAFVDIGLEKAAFLYVADVFDAMEEFDSFMDRNGEDGEGEQQVLQPLHPIEELLQEGQEILVQVSKEPIGTKGARITSHISLPGRHLVYMPTVDHVGISRRIEEEPERERLKEIVERMKPQNGGFIVRTAAEGKSEEDLVSDMNYLTKLWDEVVKRNDKGHAPSLIHADLDVTQKVIRDILTEDVSRIVVDSKTEHDKIVQFISTFMPKMKYSMELYDDEEPIFDHFGLEVEISRALGRKVWLKSGGYIIIEQTEALTAIDVNTGRFVGKHNLEDTILKTNLEAVKEIAYQLRLRNIGGIIIIDFIDMEKEVNREKVFTALEEAMKADKSKTNILKISELGLVEMTRKRVRESIGRMMCEPCPYCEGRGYVKSKTTVCHEIFRELRREMLDIRGTKATLTVHPQVADLLYDEERRGLEELEKKFKKRITVRAKPGFHQEQFEIAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QT8</accession>
    <name>Q39QT8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aspartate/glutamate/phosphoserine/alanine/cystea te aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3173</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513889.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3173"/>
    <dbReference type="EnsemblBacteria" id="ABB33386">
        <property type="protein sequence ID" value="ABB33386"/>
        <property type="gene ID" value="Gmet_3173"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3173"/>
    <dbReference type="eggNOG" id="COG0075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027686_1_1_7"/>
    <dbReference type="OMA" id="KNWLPIM"/>
    <dbReference type="OrthoDB" id="996960at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024169">
        <property type="entry name" value="SP_NH2Trfase/AEP_transaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000524">
        <property type="entry name" value="SPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="4">
        <location>
            <begin position="86"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000524-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="357" mass="39137" checksum="41B8DED997D2F53C" modified="2005-11-22" version="1">MAKKLFIPGPVEVHPDILQAMATPMVGHRMAEYATLHGRVTTGLKKLLATEAKVFLSTSSAFGAMEGAVRNLVAGRCVNFCNGAFSDKWHDVTRRCGKEADAVKVEWGKPITAELVDEALATGKYDSLTLIHNETSTGVMSPLPEIAAVLRKYPDVVSIIDTVSSMSALPIPVDELGIDCCIFGVQKAFALPPGLAVFTASEKALARARTVEGRGYYFDFLEFEASDAKNNTPSTPCISLIYAMDKQLERMFAEGFEQRWARHRALADFVRGWVSDRGYGFFAEEAYRSMTLTCAVNSRGTDLASLKKMLGERGFAFDDGYGKIKGKTFRIPHMGDMQRSDLEEFLAVIDECLAVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QT9</accession>
    <name>Q39QT9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3172</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513888.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33385">
        <property type="protein sequence ID" value="ABB33385"/>
        <property type="gene ID" value="Gmet_3172"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3172"/>
    <dbReference type="HOGENOM" id="CLU_2915978_0_0_7"/>
    <dbReference type="OMA" id="KECGACG"/>
    <dbReference type="OrthoDB" id="2033634at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="59" mass="6459" checksum="73F5888B065AAA1F" modified="2005-11-22" version="1">MKCPNCGNRTSVEIDIHSEGFSAEESPVKECGECGLVWRVRIVKGEPEIDIIKAGKKGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QW1</accession>
    <name>LIPA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoyl synthase</fullName>
            <ecNumber evidence="1">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lip-syn</fullName>
            <shortName evidence="1">LS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipoate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipoic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sulfur insertion protein LipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lipA</name>
        <name type="ordered locus">Gmet_3150</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + 4 H(+) + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + 2 5'-deoxyadenosine + [[Fe-S] cluster scaffold protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513866.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QW1"/>
    <dbReference type="SMR" id="Q39QW1"/>
    <dbReference type="STRING" id="269799.Gmet_3150"/>
    <dbReference type="EnsemblBacteria" id="ABB33363">
        <property type="protein sequence ID" value="ABB33363"/>
        <property type="gene ID" value="Gmet_3150"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3150"/>
    <dbReference type="eggNOG" id="COG0320">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033144_2_1_7"/>
    <dbReference type="OMA" id="GRCPNRG"/>
    <dbReference type="OrthoDB" id="1184806at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102552">
        <property type="term" value="F:lipoyl synthase activity (acting on glycine-cleavage complex H protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102553">
        <property type="term" value="F:lipoyl synthase activity (acting on pyruvate dehydrogenase E2 protein)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="PTHR10949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005963">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000012225" description="Lipoyl synthase">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="47"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="283" mass="30825" checksum="033B7F6800B66BE4" modified="2005-11-22" version="1">MTIVRKPQWLQKKINPAAHAGMEGLLGELRLHTVCQEARCPNITECFRERQATFLILGAACTRLCSFCNVTKQTPIPPDPGEPDRVAEAIRRLGLSHVVITSPTRDDLPDGGAGHYAETVAAIRSASPATTVELLIPDYLGNRESLARVVASAPAIIGHNVETVPRLYQIRAGADYGRSLGVLRTLRELDPVVRSKSGIMLGLGEAEEEVLAVFADLRSVGCSYLSIGQYLAPSKSHHPVREFIPPECFERYRAAALATGFAHVESGPYVRSSYHAARYDGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QW6</accession>
    <name>Q39QW6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513861.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3145"/>
    <dbReference type="DNASU" id="3741114"/>
    <dbReference type="EnsemblBacteria" id="ABB33358">
        <property type="protein sequence ID" value="ABB33358"/>
        <property type="gene ID" value="Gmet_3145"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3145"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1666898_0_0_7"/>
    <dbReference type="OMA" id="MNLDYVL"/>
    <dbReference type="OrthoDB" id="1508298at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="15"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="100"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="158" mass="17785" checksum="04B5AC7091D21581" modified="2005-11-22" version="1">MSEQGAVCYTFEAAVEMAIQMEEEGFRHYLAAIRKVKHKGAREILKEAALDELEHKHSLEQALLEGEMEGAGALDRQISTMNLGYVLAKKELSPNSDTREALAYAIHLEKGSMDFYKRMSQGCAGAPMAGIFEKMLADEAKHLQQLEDLYEEHFMTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R16</accession>
    <name>Q39R16_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Flagellar biosynthetic protein FlhB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13 15" type="primary">flhB</name>
        <name evidence="15" type="ordered locus">Gmet_3094</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the type III secretion exporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514548.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3094"/>
    <dbReference type="EnsemblBacteria" id="ABB33308">
        <property type="protein sequence ID" value="ABB33308"/>
        <property type="gene ID" value="Gmet_3094"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3094"/>
    <dbReference type="eggNOG" id="COG1377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041013_1_2_7"/>
    <dbReference type="OMA" id="DEYKQQE"/>
    <dbReference type="OrthoDB" id="1424100at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006136">
        <property type="entry name" value="FlhB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00950">
        <property type="entry name" value="TYPE3IMSPROT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00328">
        <property type="entry name" value="flhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 13" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="15" id="KW-0966">Cell projection</keyword>
    <keyword evidence="15" id="KW-0969">Cilium</keyword>
    <keyword evidence="15" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 13" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB33308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="353" mass="39689" checksum="2180CA2B95157E3E" modified="2005-11-22" version="1">MSEEDKHSKTEQPTPKRLDEAKKKGVPHSRDLTSTVTLIASMVALYTTGGFMFTTLKSTTSEIFGSMGTFQLTESSVEMLLVKLFLVMLQVVGPFMLVVVIVGLFTTVAQVGFSMNAERIAFKPEKLNPAENFGKLFNKDSFMEMAKATLKILIVGYMSYKIMRDELDGIIYLTDTDLSGILELFKHLCFKLVIHTCGVLLILGIVDLVFVKWRFIERQKMTKQEVKDEHKESEGDPKVKGKIRQMQFQQAQRRLRAVIPTADVVITNPTHFAVALKYDRLTMAAPTVLAKGADHMAQTIKAMARENNVMLVENRFLARELYAQVKEGEEIPEALYAAVAEVLAYVYSLKGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R47</accession>
    <name>Q39R47_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513622.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3062"/>
    <dbReference type="EnsemblBacteria" id="ABB33277">
        <property type="protein sequence ID" value="ABB33277"/>
        <property type="gene ID" value="Gmet_3062"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3062"/>
    <dbReference type="eggNOG" id="COG4913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009040_0_0_7"/>
    <dbReference type="OMA" id="ETQTPFY"/>
    <dbReference type="OrthoDB" id="83676at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001238">
        <property type="entry name" value="DNA-binding_RecF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32182:SF0">
        <property type="entry name" value="PTHR32182:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="443"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="681"/>
            <end position="773"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1140" mass="128183" checksum="44CF91EBD6801223" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R73</accession>
    <name>Q39R73_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_3036</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514350.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3036"/>
    <dbReference type="EnsemblBacteria" id="ABB33251">
        <property type="protein sequence ID" value="ABB33251"/>
        <property type="gene ID" value="Gmet_3036"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3036"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_0_7"/>
    <dbReference type="OMA" id="MGSNMIT"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="23"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="315"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="409" mass="43468" checksum="6BE10C22393597AD" modified="2005-11-22" version="1">MTTLWQSLLIALRALRVNKMRALLTMLGIIIGIAAVIAMVAIGAGASKMISDQISSIGSNLLLVLPGSTTSGGLRTGAGGTPTLTYDDARAIKAECPSVENVAPTVRGSAQIVYGNQNWSTIVMGCTPEMVVVRDWSLTTGRNISLSDVDGATKNCLIGQTVAENLFGDADPIGKIIRIKKIPFTVIGILDHKGQSPQGTDQDDVIFVPLRTAQRKLFGSQFPNTVGAMMIQAKSADVLKKAEEEVTALLDQRHRIGPSRERDFTVRNLSEILAVSEQSSKVMSILLGAVASISLVVGGIGIMNIMLVSVTERTREIGIRMAIGAKQRDILLQFLTEAVLLTTAGGIIGMGLGVAGAMAVSKIMQWPTLISTQAIIIAFLFSAGVGVFFGFYPARKAANLNPIEALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RA9</accession>
    <name>Q39RA9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514491.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33215">
        <property type="protein sequence ID" value="ABB33215"/>
        <property type="gene ID" value="Gmet_3000"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3000"/>
    <dbReference type="eggNOG" id="ENOG5032YN2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122371_0_0_7"/>
    <dbReference type="OMA" id="YERWGPF"/>
    <dbReference type="OrthoDB" id="1647498at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="149" mass="16323" checksum="47DDEE8D5B641282" modified="2005-11-22" version="1">MNRLLLILRYLWASPASVLGLLLAAVAICLGATCRVADGVVEVAGGKLFRLFPLLPRIFHFEAITFGHVVIGLDHSLLAQLRTHEHVHVRQYERWGILLIPLYLGSSAVQKLLGRNPYLHNRFELEAFAKAAAPPAGVHASAEKTDANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RE6</accession>
    <name>Q39RE6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512895.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2961"/>
    <dbReference type="EnsemblBacteria" id="ABB33178">
        <property type="protein sequence ID" value="ABB33178"/>
        <property type="gene ID" value="Gmet_2961"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2961"/>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153953_1_0_7"/>
    <dbReference type="OMA" id="NLSKTAM"/>
    <dbReference type="OrthoDB" id="2032706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="93" mass="10221" checksum="14113B711DF6B50F" modified="2005-11-22" version="1">MKNEHVGSSFDDFLEEEGLRAEAEAAAIKRVIAFQIEQEMKLANLSKTAMAERMCTSRTALDRLLDPANVSVTLQTLERAALALGKSLKIELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RI3</accession>
    <name>Q39RI3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_2923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366124.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39RI3"/>
    <dbReference type="STRING" id="269799.Gmet_2923"/>
    <dbReference type="EnsemblBacteria" id="ABB33141">
        <property type="protein sequence ID" value="ABB33141"/>
        <property type="gene ID" value="Gmet_2923"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2923"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_29_7"/>
    <dbReference type="OMA" id="CAGIVKG"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="215"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="309"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="541" mass="59830" checksum="D66F12229E591F3C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RJ4</accession>
    <name>Q39RJ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2912</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512848.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2912"/>
    <dbReference type="EnsemblBacteria" id="ABB33130">
        <property type="protein sequence ID" value="ABB33130"/>
        <property type="gene ID" value="Gmet_2912"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2912"/>
    <dbReference type="eggNOG" id="COG0633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089211_1_0_7"/>
    <dbReference type="OMA" id="CDRACPK"/>
    <dbReference type="OrthoDB" id="1605514at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="224" mass="24678" checksum="02C91922DF1F3EFE" modified="2005-11-22" version="1">MKNSAMFIIVELEGRKIRIPEGLTVIEALWDTGYDVKRGIGCLSGLCGACTVAFIERESTKVKFGLGCQKVAEEGLNVIMMPCFPSRAARYAMEAMAHPLEELGTHYPELYTCNDCGACNVCPEWINVAGVMKFAKDGDYEAAASRVTDCIMCGLCASRCPKSIAPQYVALYIQRALARERPFPPNLAKRLTQMESFVFEAEWSRIVAMGDDELKAYCAAMEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RP9</accession>
    <name>Q39RP9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sodium/anion symporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2857</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514559.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2857"/>
    <dbReference type="EnsemblBacteria" id="ABB33075">
        <property type="protein sequence ID" value="ABB33075"/>
        <property type="gene ID" value="Gmet_2857"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2857"/>
    <dbReference type="eggNOG" id="COG0471">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005170_0_1_7"/>
    <dbReference type="OMA" id="LHGMNTY"/>
    <dbReference type="OrthoDB" id="626718at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030676">
        <property type="entry name" value="CitT-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001898">
        <property type="entry name" value="SLC13A/DASS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00939">
        <property type="entry name" value="Na_sulph_symp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002457">
        <property type="entry name" value="DASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00785">
        <property type="entry name" value="dass"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="452"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="482" mass="51723" checksum="4A64D12BFDB5F554" modified="2005-11-22" version="1">MERELFDKPLKIDTRPLWLILIDRSARYQVFAGLIIACAILFRLTPPEGLSAAGYHALIVFGATIFLWISGLLPIAVTALFSMALLPLLGIMEAKKTYALFGNEAVFFIIGAFILAAAMTGTGLSARLARAMLARFGKTPRSLALTVFLLSAILSFCMSEHAVAAMMFPVVEEIGTSLGLERGRSRYAKLLFMSMAWGCIIGGIATFLGGARAPLAVGMLRETSGLDYTFFEWTVAAIMIVAPLLVIGFLLLLLFFPPDIAGVDEGLRFLNRKRLETGKMGYGEMTVAAVMVVTIACWMALGKELGLANIAILAMVALFVFRVVSWQTIEEYVNWGIILMYGGSIALATALEKTGAALWIVERGLGAFSPSPLMVIAVISLVSILLTECISHAAVVAILMPIGMSLAKSLGMDLKVMTLAIALPAGLAYCLPMGTPATAIAYASGYLRSKDIIIPGALVMAISWLLFMAAAIFIWPLIGLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RU4</accession>
    <name>Q39RU4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate kinase, PfkB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513993.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2812"/>
    <dbReference type="DNASU" id="3741078"/>
    <dbReference type="EnsemblBacteria" id="ABB33030">
        <property type="protein sequence ID" value="ABB33030"/>
        <property type="gene ID" value="Gmet_2812"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2812"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027634_2_2_7"/>
    <dbReference type="OMA" id="CSGMPPE"/>
    <dbReference type="OrthoDB" id="1030724at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="1">
        <location>
            <begin position="17"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="321" mass="33919" checksum="7CFF0BD5A0C25910" modified="2005-11-22" version="1">MGTGRNGGRAIVATGLGQCCWDTLAVVDSYPSPDSKAEAAVWAEQAGGPTATALVALARLGIPCRFAGVVGDDDAGSRIRQALDSEGVDGAFLVTRRRGASQRAFIMIERGSGRRTIVWRRPTGDPLDPREVPDAFLAGSSLLLLDGLMADASLHAAGRARSLGIPVMVDAGRMRPGMLDITRQCDYVVAAEQFFLDLGWDRTPEHFRGLAADLGAPVVTVTLGAAGSLTWSGHEPFHVPAFTVDAVDTTGAGDVFHGGYGYGILQGWSVRETVVFASAMAAMKCRQVGAQQGIPRLPDVLEFLTRRTITVLSNPQTEVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RU8</accession>
    <name>Q39RU8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translocation and assembly module subunit TamA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autotransporter assembly factor TamA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_2808</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TamA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514676.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2808"/>
    <dbReference type="EnsemblBacteria" id="ABB33026">
        <property type="protein sequence ID" value="ABB33026"/>
        <property type="gene ID" value="Gmet_2808"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2808"/>
    <dbReference type="eggNOG" id="COG0729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018618_1_0_7"/>
    <dbReference type="OMA" id="NTTMLLY"/>
    <dbReference type="OrthoDB" id="470487at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035243">
        <property type="entry name" value="TamA_POTRA_Dom_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17243">
        <property type="entry name" value="POTRA_TamA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="9">
        <location>
            <begin position="216"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="603" mass="66184" checksum="F59062CDF174A52D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RV6</accession>
    <name>Q39RV6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33018.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514683.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2800"/>
    <dbReference type="EnsemblBacteria" id="ABB33018">
        <property type="protein sequence ID" value="ABB33018"/>
        <property type="gene ID" value="Gmet_2800"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2800"/>
    <dbReference type="eggNOG" id="COG5635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_400510_0_0_7"/>
    <dbReference type="OrthoDB" id="739991at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33018.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="687" mass="77217" checksum="3CC556276FC9B493" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RZ0</accession>
    <name>Q39RZ0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex</fullName>
            <ecNumber evidence="5 10">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">sucB</name>
        <name evidence="14" type="ordered locus">Gmet_2766</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(R)-N(6)-dihydrolipoyl-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + succinyl-CoA = (R)-N(6)-(S(8)-succinyldihydrolipoyl)-L-lysyl-[2-oxoglutarate dehydrogenase complex component E2] + CoA</text>
            <dbReference type="Rhea" id="RHEA:15213"/>
            <dbReference type="Rhea" id="RHEA-COMP:10581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10582"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="2.3.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="10">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="5 10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511695.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2766"/>
    <dbReference type="EnsemblBacteria" id="ABB32984">
        <property type="protein sequence ID" value="ABB32984"/>
        <property type="gene ID" value="Gmet_2766"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2766"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_0_0_7"/>
    <dbReference type="OMA" id="MKVPSPG"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="UniPathway" id="UPA00868">
        <property type="reaction ID" value="UER00840"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033512">
        <property type="term" value="P:L-lysine catabolic process to acetyl-CoA via saccharopine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="13">
        <location>
            <begin position="92"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="418" mass="44848" checksum="AA48DA2994236044" modified="2005-11-22" version="1">MEIKVPSVGESVYEALVGKWLKKNGEAVRKDEPVCEIETDKITMEIDAGADGVLTIMVPEGATVKIGSVIGIIEAGTGDRGPGTGKGKEVPPLSPAVRKIAQELGIKPETVHGSGRGGRVTVDDLLTAGTRDLTAGTGDRGPGTGKGGEVPKDAAVKSGEAAAVGGKQKEFAFEPVPGPRSPVPAAERVTRSPMTPIRKRIAERLLVARQQTAMLTTFNEADLGRVMELRKKYKEHFQKKHGVSLGFMSFFVKACVEALKEYPAVNGSIEGDDIVFHHYYHIGIAIGAEKGLVVPVLRDADRLSFAEIETTIAGFAEKTKANRLELSDLQGGTFTISNGGVYGSLLSTPILNPPQSGVLGMHAVQERPVVRDGQIVIRPMMYLALSYDHRIIDGREAVGFLKKVKEYVEEPEELFLEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-08" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S27</accession>
    <name>ACYP_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName>Acylphosphatase</fullName>
            <ecNumber>3.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Acylphosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">acyP</name>
        <name type="ordered locus">Gmet_2729</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction>
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511731.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39S27"/>
    <dbReference type="SMR" id="Q39S27"/>
    <dbReference type="STRING" id="269799.Gmet_2729"/>
    <dbReference type="EnsemblBacteria" id="ABB32947">
        <property type="protein sequence ID" value="ABB32947"/>
        <property type="gene ID" value="Gmet_2729"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2729"/>
    <dbReference type="eggNOG" id="COG1254">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141932_1_0_7"/>
    <dbReference type="OMA" id="GTVEAMF"/>
    <dbReference type="OrthoDB" id="2034659at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="PTHR47268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000326715" description="Acylphosphatase">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Acylphosphatase-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="93" mass="10610" checksum="C7059FEAE90525D8" modified="2005-11-22" version="1">MTMKIRAIVTVKGLVQGVAFRHHTVLQGNQLRVTGWVKNLPNGDVQGCFEGDETDVQALVEWCHHGPSRARVDRVIVERKSFRGEFDTFDVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S77</accession>
    <name>Q39S77_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366081.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2679"/>
    <dbReference type="EnsemblBacteria" id="ABB32897">
        <property type="protein sequence ID" value="ABB32897"/>
        <property type="gene ID" value="Gmet_2679"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2679"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="PLMEVIM"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="129" mass="14792" checksum="331CDD2EF3929584" modified="2005-11-22" version="1">MAEQAKKRILVVDDEENARIGLSKLLEREGFEVESVSNGYEALNYLNQRQVNVIVTDINMPEMNGITFLKELNKNFPASNVIMITAYGGVESYIEAMNLGAFEYINKPIKIDELKSILKKIFKEKEHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SK3</accession>
    <name>Q39SK3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Smr domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513482.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2552"/>
    <dbReference type="EnsemblBacteria" id="ABB32771">
        <property type="protein sequence ID" value="ABB32771"/>
        <property type="gene ID" value="Gmet_2552"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2552"/>
    <dbReference type="eggNOG" id="COG2840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055978_0_1_7"/>
    <dbReference type="OMA" id="MIKSHVN"/>
    <dbReference type="OrthoDB" id="1888882at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="153"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="242" mass="26326" checksum="98049742DD232A48" modified="2005-11-22" version="1">MKKKSSKTEQKPREFAARPFAALKGLKPDDATARDAAPAKAPVPPPPKRAAEPDDLSLFLREMADVRRIRPAAEPSPKKGGEKAPEPRELAEAAEIRRQQEAEEHRVFANAISNLRLDVTFSDHLPEEKGEAPRPTSRLKQLKSGQIRVGLELDLHGLTKEEALESLESFIAAAHRRDQKAVLVITGKGNNSPGEPVLQGAVLSWLRERGKGKVAEFAPAPRELGGSGAIVVFLRTPGKKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SN6</accession>
    <name>Q39SN6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux pump, RND family, outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514534.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2517"/>
    <dbReference type="EnsemblBacteria" id="ABB32738">
        <property type="protein sequence ID" value="ABB32738"/>
        <property type="gene ID" value="Gmet_2517"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2517"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_6_7"/>
    <dbReference type="OMA" id="QAYWQVV"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="455" mass="50481" checksum="D9FB8F8E25843303" modified="2005-11-22" version="1">MTDQRFDDTGKSGIYRALENKLRIFSVAPLLCVIWLLHGISMAAEHRVLTLDQALEVAAERNRDILKAKEFHNQVRGRYVEERSAALPHLTITGQAVTQHDESLNAYADGFMPVRQDIYGAELGLSQALYTWGKVGAAIRAAEKGFATADEQFRRARQDAWRDVSVAFYNILLAREQHAIASQNLAQKVRHQDEAQRRYAAGVATDYDVLAADVAVQNAMPDVIRAGNSVRVARDRLSFLLALEGEVDVTGSLETVLTTYPSYDKALAVARDKRPELKEIKHRLAIAGELVKVADADDKPRLDLTGKYGWRHLEVGDGSGSGQIWTVGLQLSFPLFDGLKTRGKVAQAESERRSMQIDEAKLLESVALEIRDAVNAVRESEEIVKALSGTVVQAERLLQMAEKGFELGVKIRLEVDDAELNLRQARGNLARARRDYLVARVNLERVMGVLGEGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T28</accession>
    <name>Q39T28_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-associated metal-dependent phosphohydrolase, HDc domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2371</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366045.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2371"/>
    <dbReference type="EnsemblBacteria" id="ABB32596">
        <property type="protein sequence ID" value="ABB32596"/>
        <property type="gene ID" value="Gmet_2371"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2371"/>
    <dbReference type="eggNOG" id="COG1480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015767_1_2_7"/>
    <dbReference type="OMA" id="ARSCAYY"/>
    <dbReference type="OrthoDB" id="1124669at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011624">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_extra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011621">
        <property type="entry name" value="Metal-dep_PHydrolase_7TM_intra"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07698">
        <property type="entry name" value="7TM-7TMR_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07697">
        <property type="entry name" value="7TMR-HDED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="320"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="HDc" evidence="3">
        <location>
            <begin position="542"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="802" mass="88077" checksum="57F44DB3E8A7DE94" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T52</accession>
    <name>LPXK_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tetraacyldisaccharide 4'-kinase</fullName>
            <ecNumber evidence="1">2.7.1.130</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipid A 4'-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxK</name>
        <name type="ordered locus">Gmet_2347</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-beta-D-glucosaminyl}-(1-&gt;6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate} = ADP + {2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-4-O-phospho-beta-D-glucosaminyl}-(1-&gt;6)-{2-N,3-O-bis[(3R)-3-hydroxytetradecanoyl]-alpha-D-glucosaminyl phosphate}.</text>
            <dbReference type="EC" id="2.7.1.130"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LpxK family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB32572" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="2.7.1.130" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32572.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T52"/>
    <dbReference type="SMR" id="Q39T52"/>
    <dbReference type="STRING" id="269799.Gmet_2347"/>
    <dbReference type="EnsemblBacteria" id="ABB32572">
        <property type="protein sequence ID" value="ABB32572"/>
        <property type="gene ID" value="Gmet_2347"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2347"/>
    <dbReference type="eggNOG" id="COG1663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038816_6_0_7"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00482"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009029">
        <property type="term" value="F:tetraacyldisaccharide 4'-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00409">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003758">
        <property type="entry name" value="LpxK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42724">
        <property type="entry name" value="PTHR42724"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02606">
        <property type="entry name" value="LpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00682">
        <property type="entry name" value="lpxK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000229956" description="Tetraacyldisaccharide 4'-kinase">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="49"/>
            <end position="56"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="338" mass="35657" checksum="A698FED1917BF2C5" modified="2006-04-04" version="2">MLDRLVLALLAVLSVPYALAVRLRALAYGAGIFRVKQLNRPVISVGNLTVGGTGKTPMVALVARLLMARGKRVAVISRGYGGSLEGKTHIVSDGQRVFLSAAEAGDEPVHLATAVPGLMAVIGTDRYAAGLLAQERLNPDVFILDDGFQHLRLHRDLNILLMDCSAPLGNGMVLPAGLLREPPLALKRADLVVYTRCTGAEAPAVHGAIPSCRAGHVLAGVELLPGGERQPFTALYGRRGVAFAGIADPDAFFASLREEGVDLAATVSFGDHCPYGEEEVARLMAARRTAGADFLITTGKDAVKLGPVLSRLGIVYAAVLEMSLMDPKPLETAIDKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TG6</accession>
    <name>Q39TG6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365986.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2231"/>
    <dbReference type="EnsemblBacteria" id="ABB32458">
        <property type="protein sequence ID" value="ABB32458"/>
        <property type="gene ID" value="Gmet_2231"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2231"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_7"/>
    <dbReference type="OMA" id="SMRYELP"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="257" mass="27283" checksum="7D32568E2EDF922D" modified="2005-11-22" version="1">MHVSELFSLKGKTAIITGGSRGLGLMMAEGFAEAGASLVLCSRNLEQCEDAAANIRKLGVECDALRCDIGEQDEVKAVVAHTMNRFGKIDILVNNAGISWGGELQDTPLKKWDQLYSTNVRGNYFFTTEVVSPMIAGGGGNIINIVSIGGVRSTDPKVVTFPAYASTKGAIIALTKHLSRNWAKHNIRVNAIAPGIFPTEISKTLMVGPQKAVMEAAVPLGRLGEKDDFKGAALFLAADASRYVTGSVLWVDGGMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TI7</accession>
    <name>Q39TI7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase, ArgK family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2210"/>
    <dbReference type="EnsemblBacteria" id="ABB32437">
        <property type="protein sequence ID" value="ABB32437"/>
        <property type="gene ID" value="Gmet_2210"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2210"/>
    <dbReference type="eggNOG" id="COG1703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043725_1_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="330" mass="35908" checksum="DA66F39519944DA9" modified="2005-11-22" version="1">MKTLDRSISRLISLLERRNPEGIEELKGLYCKCGRAHVIGITGPPGAGKSCLVAALVREIRRRGKTVGVLAVDPSSPFSDGAILGDRARMTEFSGDNGVFIRSFSARGASGGLAPVINDAVDVLDAFGKEVIIVETVGVGQVEMDIAKIAHTVVLTLVPGYGDSLQAMKAGILEIGDILVVNKSDQPGADGAVNDLSFEMPVTYGGKEFQCANIKADQWGVPIAKVSALKGDGVEDLVTVIFEHLMFITERNIFTGICQKRRSRQFLDILTQQVRDRFLETLKTDRDLQKWINKIENLKLDPYSASEQVVDLVEKARILADNGTTPRNNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TL2</accession>
    <name>Q39TL2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic polysaccharide biosynthesis/export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2184</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365941.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2184"/>
    <dbReference type="EnsemblBacteria" id="ABB32412">
        <property type="protein sequence ID" value="ABB32412"/>
        <property type="gene ID" value="Gmet_2184"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2184"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011447_2_1_7"/>
    <dbReference type="OMA" id="VMGEVQH"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010425">
        <property type="entry name" value="Caps_synth_GfcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06251">
        <property type="entry name" value="Caps_synth_GfcC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="206"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="291"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="474"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="570"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Caps_synth_GfcC" evidence="3">
        <location>
            <begin position="622"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="833" mass="92010" checksum="691873DBC3B57A7C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TL3</accession>
    <name>Q39TL3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polysaccharide chain length determinant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_2183</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365940.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2183"/>
    <dbReference type="EnsemblBacteria" id="ABB32411">
        <property type="protein sequence ID" value="ABB32411"/>
        <property type="gene ID" value="Gmet_2183"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2183"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051175_1_0_7"/>
    <dbReference type="OMA" id="LFMPNIY"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="20"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="9">
        <location>
            <begin position="298"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="196"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="409" mass="45312" checksum="83193385C6A85700" modified="2005-11-22" version="1">MMLHSENSTDDTRTSKPLFTLLDFAAVIIKHWRLTACITLAAALVAVIYTLMLPNLYTARSMILPLEDDREGVGAALGQLAGLAGVGRIGLGNPSKADVYLAMLNGETIRDPLIDRFRLLEAYEAKYRTEAYGALDRNVAVTVGKKDGIITIAVDDRDPRRAAEMANAYVEELGRLANRLNMASAGNDRMYLEKRLASARVDLAKAEDALKAFQSKNKAVSVSDQAKATIDGVAQLRAQLAAQEVQLSAYRSQFTDSSQEVRTSKAAIGRLQAQIARLEGNGGGGSAIPSVGSMPQLGQQYLRLMRDFKIQETMVELLAKQYEVARMSEVKDVSPFQVLQVAKVPEKKSKPHRTLIVLVAALTAFLCSIYLSFVLEHLDRMSEQDKMRWFELKSRLLFWKKQKLTLQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TN2</accession>
    <name>Q39TN2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Laccase family multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ompB</name>
        <name evidence="4" type="ordered locus">Gmet_2163</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365924.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2163"/>
    <dbReference type="EnsemblBacteria" id="ABB32392">
        <property type="protein sequence ID" value="ABB32392"/>
        <property type="gene ID" value="Gmet_2163"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2163"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001857_0_0_7"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223382" evidence="2">
        <location>
            <begin position="26"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="778"/>
            <end position="852"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1201" mass="129400" checksum="028CF34CC0329D69" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TN8</accession>
    <name>Q39TN8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional response regulator, AraC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2157</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513048.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2157"/>
    <dbReference type="DNASU" id="3741309"/>
    <dbReference type="EnsemblBacteria" id="ABB32386">
        <property type="protein sequence ID" value="ABB32386"/>
        <property type="gene ID" value="Gmet_2157"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2157"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1101648_0_0_7"/>
    <dbReference type="OMA" id="IMTAFEM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018060">
        <property type="entry name" value="HTH_AraC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018062">
        <property type="entry name" value="HTH_AraC-typ_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020449">
        <property type="entry name" value="Tscrpt_reg_HTH_AraC-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12833">
        <property type="entry name" value="HTH_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00032">
        <property type="entry name" value="HTHARAC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00342">
        <property type="entry name" value="HTH_ARAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00041">
        <property type="entry name" value="HTH_ARAC_FAMILY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01124">
        <property type="entry name" value="HTH_ARAC_FAMILY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="HTH araC/xylS-type" evidence="3">
        <location>
            <begin position="149"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="250" mass="27792" checksum="97534D41A251A548" modified="2005-11-22" version="1">MSLAQSIVVVAEPSHSDLYDLLAVGNAGIRLVSAAGLSTAIGPSDPDIVILDSGTDADGGITLLGEIKALRNDLPVIFLTDSSSEEIVLKAFRKGAREYFRKPVDLHVLQHAVETILALRRMQRERRDPLKRHYSDPINLPDDLPESIGRAVMHIKSNYDCALYLDDLARAAHLSKFHFCRNFKKYIGVSPMRFMNMVKISKAETLLRRADLTISTVAYKLGFNDPSEFTRQFKSITGISPSAFRRSCLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TR2</accession>
    <name>Q39TR2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix-turn-helix transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pcmQ</name>
        <name evidence="2" type="ordered locus">Gmet_2133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513072.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2133"/>
    <dbReference type="EnsemblBacteria" id="ABB32362">
        <property type="protein sequence ID" value="ABB32362"/>
        <property type="gene ID" value="Gmet_2133"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2133"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_6_7"/>
    <dbReference type="OMA" id="TVVKMAT"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="137" mass="15519" checksum="B77A0DDC01AE896C" modified="2005-11-22" version="1">MISYRDHIVFLIAKAHQRAQGALKGHLLPFGLTPMQCLFLEALMEEDGLSVGEIGRRIALDTATLAGILDRMVTAGWVRRETDSQDARVARVYLTEKAAAAIPELSASIERTNDELMRNFSLEEKLLMKRFLRDFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TU6</accession>
    <name>Q39TU6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic catabolism-like sigma-54-dependent transcriptional regulator, XylR and V4R domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2099</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513105.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2099"/>
    <dbReference type="EnsemblBacteria" id="ABB32328">
        <property type="protein sequence ID" value="ABB32328"/>
        <property type="gene ID" value="Gmet_2099"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2099"/>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_2_7"/>
    <dbReference type="OMA" id="RIWLNDQ"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010523">
        <property type="entry name" value="XylR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06505">
        <property type="entry name" value="XylR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="238"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="574" mass="64022" checksum="7AA004E02D786BC2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TU8</accession>
    <name>Q39TU8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix-turn-helix benzoyl-CoA degradation transcriptional repressor BgeR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bgeR</name>
        <name evidence="1" type="ordered locus">Gmet_2097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513107.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2097"/>
    <dbReference type="EnsemblBacteria" id="ABB32326">
        <property type="protein sequence ID" value="ABB32326"/>
        <property type="gene ID" value="Gmet_2097"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2097"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_2_1_7"/>
    <dbReference type="OMA" id="LQKSTMC"/>
    <dbReference type="OrthoDB" id="1765806at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="143" mass="15790" checksum="F67629240E795C81" modified="2005-11-22" version="1">MRLNKASLFALFAVLELASDPERQLSTGEIASKYGVSPHHLAKIMRDLVHEGLVQAVRGVGGGYRFSGNIQRTTLLDIIQMFENLESELDVPHGSPLDVPILEELKSIANEIDDLTKAVLDTITLETALKGARQRVEIRTQNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TX1</accession>
    <name>Q39TX1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bamN</name>
        <name evidence="7" type="ordered locus">Gmet_2074</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514591.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2074"/>
    <dbReference type="EnsemblBacteria" id="ABB32303">
        <property type="protein sequence ID" value="ABB32303"/>
        <property type="gene ID" value="Gmet_2074"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2074"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_7"/>
    <dbReference type="OMA" id="TNVCCTT"/>
    <dbReference type="OrthoDB" id="1058688at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="268"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="391" mass="41057" checksum="EF9C3DB837634848" modified="2005-11-22" version="1">MSDVYVIESLRTPLGSFGGELSDVEAPRLAATVIRELLQRSGLPAEGVDEVIVGQVLAGGTGQAPARQAMRYAELPDSIPAMTINKVCGSGLKALMLGADAIRLGDVGVVIAGGMENMSLAPYVLSKGRNGYRLGNGELIDLLVNDGLLDPYSGNHMGVIAEATTEKHGISRADQDAFAFRSYQKAQTAVKEGIFRDEIVPVVKKGRKGDVTVSDDEEPFKVDFTKLMGLKSAFKKEGTITAGNASTINDGAALTLLASGEAVKKYGLKPRARLVAYASNSLHPDQFTEAPVGAIEKACAKAGLKLEDIDLFEINEAFAAVTMLAIKQLGLDPEKVNVNGGAVAIGHPLGASGGRLAATLVRELHRRQARFGLATLCIGGGEAVAAIFERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TX4</accession>
    <name>Q39TX4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514032.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2071"/>
    <dbReference type="EnsemblBacteria" id="ABB32300">
        <property type="protein sequence ID" value="ABB32300"/>
        <property type="gene ID" value="Gmet_2071"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2071"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_7"/>
    <dbReference type="OMA" id="ELSMSCD"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="27415" checksum="AB26A8BC965E9B22" modified="2005-11-22" version="1">MGTENLLVDIKDGVALLTINRPKVLNALHTSVIAELQETFEALNANQAVKAVVITGSGEKAFVAGADIAEMAVMDAQQALVFARTGQKLVNYIGTMPKPVIAAVNGFALGGGMELALACDFIYASENAKMGLPEVTLGIMPGFGGSQKFARLLGRSRANELIFTGKMLTAAEAKEWGIVNAVLPLAELVGKALETAARIAGNGLLGVAHVKEAIRRGLDMTEPDGMDYESVLFASLFASRDQKEGMGAFVEKRKPNFTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TX7</accession>
    <name>Q39TX7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sucD-2</name>
        <name evidence="2" type="synonym">sucD</name>
        <name evidence="7" type="ordered locus">Gmet_2068</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514035.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2068"/>
    <dbReference type="EnsemblBacteria" id="ABB32297">
        <property type="protein sequence ID" value="ABB32297"/>
        <property type="gene ID" value="Gmet_2068"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2068"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_7"/>
    <dbReference type="OMA" id="TVIFIPP"/>
    <dbReference type="OrthoDB" id="1081709at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="296" mass="30705" checksum="E2F259A80B682740" modified="2005-11-22" version="1">MSILINKDTKVITQGLGATGLFHAQGAREYGTQMVGGVTPGKGGTVVDGFPVYDTVRDAVNQTGATASVIYVPPPFAADAIMEAVDAGIELAICITEGIPVLDMVKVKQYMQGKKTRLVGPNCPGVITPGECKIGIMPGYIHKPGKVGVVSRSGTLTYEAVWQLTNVGLGQSTCVGIGGDPVNGTNHVDVLRMFEEDPDTEAVIMIGEIGGNSEEEGARFVKEYMTKPVAAYIAGMTAPPGKRMGHAGAIIAGGKGTATEKVAILEECGISVAQSPADMAKALLKVYKPDGLKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TZ9</accession>
    <name>Q39TZ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ThiF family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514058.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2046"/>
    <dbReference type="EnsemblBacteria" id="ABB32275">
        <property type="protein sequence ID" value="ABB32275"/>
        <property type="gene ID" value="Gmet_2046"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2046"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_3_0_7"/>
    <dbReference type="OMA" id="NIGWVTE"/>
    <dbReference type="OrthoDB" id="1543144at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="12"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="290" mass="31726" checksum="44863481A2886A3A" modified="2005-11-22" version="1">MDSDSLIRNEFARNIGLLTVEEQKRLLASRVAVAGAGGVGGIHVLTLARLGVGCFTIADHDSFDVVNISRQFGAFHSTLNRNKAQVLAEMVKDINPNAEVRVMEEGVTEDNINAFLDGVDVYVDSIDFFEIDMRRLIFNSCRAKGIYALTAAPLGFGATLQVFDPEGMSFDDYFGIDDQTPPLEKIAAFAAGLTPNPYHLSYMDASRVSFKRRTGPAVSPACTLAASLVATEIVKILTGKGELRPIPCYLQFDMLLNKVKMGKIALGAKSPSQKKKRRLIMENLLMKSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U24</accession>
    <name>Q39U24_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acpP-3</name>
        <name evidence="3" type="ordered locus">Gmet_2021</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512929.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2021"/>
    <dbReference type="EnsemblBacteria" id="ABB32250">
        <property type="protein sequence ID" value="ABB32250"/>
        <property type="gene ID" value="Gmet_2021"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2021"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_16_4_7"/>
    <dbReference type="OMA" id="MELLAFI"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="1">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="78" mass="8590" checksum="84177F0F1E9D9991" modified="2005-11-22" version="1">MTIETQLITYFKDTLDADVTPGTPLIEQGIIDSMGVMELITFIQQTFDVEFDVDDMTVEKLGTVTAISSLITSKRGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U82</accession>
    <name>Q39U82_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511881.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1963"/>
    <dbReference type="EnsemblBacteria" id="ABB32192">
        <property type="protein sequence ID" value="ABB32192"/>
        <property type="gene ID" value="Gmet_1963"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1963"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_929871_0_0_7"/>
    <dbReference type="OMA" id="WNWSANK"/>
    <dbReference type="OrthoDB" id="206240at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="299" mass="33196" checksum="F7043B240A73DF2E" modified="2005-11-22" version="1">MPWRSRVNNPHPLERARFLKPVTVLGVFCTFVAVLALLFPERSLLKSLDGKEDAATIRYREEILRVRPNDAGLRIKVAESLFRSGNYPKTLETLKQLPAGLSTEQKRTVAELRYNTFQNMLLGAGIGTPQWQSLKPRVRSAAMELTGPNPSLWRLQQLASDARKAGDLDAWGKYQKEIAAREATAVTAGQPRQDPFTLALARRDYRAAAAICFSGMHKAATVQQRRGLFMKGVRTLQAGNLPLEALRAGEQHLDGLSGDRSTLIFLTRVSLAANQPQRAQYFVRKALGMAPDHKPADPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UC9</accession>
    <name>Q39UC9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1916</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511927.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1916"/>
    <dbReference type="EnsemblBacteria" id="ABB32145">
        <property type="protein sequence ID" value="ABB32145"/>
        <property type="gene ID" value="Gmet_1916"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1916"/>
    <dbReference type="HOGENOM" id="CLU_709318_0_0_7"/>
    <dbReference type="OMA" id="PAEYMAV"/>
    <dbReference type="OrthoDB" id="1355837at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="398" mass="42783" checksum="F3E567074D22E2A8" modified="2005-11-22" version="1">MIASWRIISLKSFFSLVLLVVAMVLVVRGELLAESAPADIVTQGEFAATLVKELGWQEGLPPEPKTADYLTVLSGKRTFRFEAEDVYDVQGDSVTFRNYPLHGPFSGTGWLSGIAAPTTVHFTVFIPRGGEYLLRVVSRGDGQRWLAGGKEFTVSTGGSLREVEAGTVLLKGGRQGISVLLPPEGGVDAFTLVASGDHPAIEPLDGWHADAPLTWGDYAEAVAAALNLEKEFAVAPGTKPQILAFQNVKTLPSSVNLTSVDYLGTHVAPTWARVGADGASLELPLDVAATGVYGVRVRLLGGKLMTDFNGKRIQWDGKPYLNWYDLGITRLTKGTHTLKIQLPPRGGADVVELTARSSSPADYLAAIGLGNKKPTATVPRVELETQLRKDLSRIRPTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UF9</accession>
    <name>GLMM_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglucosamine mutase</fullName>
            <ecNumber evidence="1">5.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmM</name>
        <name type="ordered locus">Gmet_1886</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23424"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="5.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Activated by phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365883.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UF9"/>
    <dbReference type="SMR" id="Q39UF9"/>
    <dbReference type="STRING" id="269799.Gmet_1886"/>
    <dbReference type="EnsemblBacteria" id="ABB32115">
        <property type="protein sequence ID" value="ABB32115"/>
        <property type="gene ID" value="Gmet_1886"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1886"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_0_7"/>
    <dbReference type="OMA" id="VDCGNGM"/>
    <dbReference type="OrthoDB" id="1265792at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008966">
        <property type="term" value="F:phosphoglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05802">
        <property type="entry name" value="GlmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01554_B">
        <property type="entry name" value="GlmM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006352">
        <property type="entry name" value="GlmM_bact"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01455">
        <property type="entry name" value="glmM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000301320" description="Phosphoglucosamine mutase">
        <location>
            <begin position="1"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01554"/>
        </source>
    </evidence>
    <sequence length="451" mass="49033" checksum="607352F0B15A8498" modified="2005-11-22" version="1">MKKLFGTDGVRGVANVYPMTTEMAMQIGRAAAYLFKNGNRRHRIVIGKDTRLSGYMLENALVAGICSMGVDVLVVGPLPTPGIANITSSMRADAGVVISASHNAFQDNGIKFFSRDGFKLPDEMELKIEELIFSKKIDSLRPIATEVGKAYRIDDAVGRYVVFLKNTFPKELDLTGMKIVLDCANGAAYKVAPAVLEELGAEVIPYGIKPNGTNINAGFGSLHPEVISEAVKEHRADLGIALDGDADRVIFVDEFGNEVDGDHIMAICATDMLKHKKLRKNTLVATVMSNMGLDIAVKKAGGKVIKTAVGDRYVVEEMLKGGYNLGGEQSGHMIFLDHNTTGDGMLSALQVLAIMRRSGKTLSELAEVMIPLPQVLVNVRVTEKKDIMTIPEVAALIRGVEDKLKDEGRILIRYSGTEPLLRIMLEGQDKYQITGWAKEIADLVEKKIGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UG7</accession>
    <name>Q39UG7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ComEA-related DNA-binding/uptake protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511966.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1878"/>
    <dbReference type="EnsemblBacteria" id="ABB32107">
        <property type="protein sequence ID" value="ABB32107"/>
        <property type="gene ID" value="Gmet_1878"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1878"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052011_1_1_7"/>
    <dbReference type="OMA" id="ISITKMG"/>
    <dbReference type="OrthoDB" id="1948240at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="192" mass="21119" checksum="E70518E994D0DEC1" modified="2005-11-22" version="1">MRERAHLIALWTLAVLASTVLVTKGRGLPLTEGGSTAFLLDRSNGVRVKVTGIQGKSGVYCLPEDAVLKSVIIMAYRGLTANASKSSDFATRLKDGDWVMFERDASEPVKISLKTMPATERILLGIPLDPATMTESEWELLPGIGPTLARRIVFDRQYNGGFRSIRDLERVSGIGKVTVDKLERYFPNTVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UH7</accession>
    <name>Q39UH7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1868"/>
    <dbReference type="EnsemblBacteria" id="ABB32097">
        <property type="protein sequence ID" value="ABB32097"/>
        <property type="gene ID" value="Gmet_1868"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1868"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076833_0_0_7"/>
    <dbReference type="OMA" id="GRMQCTT"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="254" mass="27873" checksum="A891E594D62D853B" modified="2005-11-22" version="1">MMVKTDNLFPVLLFLIVVFFDTGAGFGAQGPKFTEGGNKHNLSFSNTGVNYKATNASDPRGKQICIFCHTPHNAKPQTVLWNRNDTTQTFGHYSSNTLAIHTDPAAKTSSDYKSEPNGSSRLCLSCHDGVTALGAVLNGDAIEVNNNVNTVMSGTHVFNRTKITNSHHPVSFVYNASVRDRLNVLEGPGNSYQLPTNAKIRLDRENRMQCITCHDPHQTQYNDPSTPFWVLDGTSATNAHDSVCTNCHNFTNNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UJ5</accession>
    <name>Q39UJ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yibQ</name>
        <name evidence="2" type="ordered locus">Gmet_1850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365876.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1850"/>
    <dbReference type="EnsemblBacteria" id="ABB32079">
        <property type="protein sequence ID" value="ABB32079"/>
        <property type="gene ID" value="Gmet_1850"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1850"/>
    <dbReference type="eggNOG" id="COG2861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041643_5_0_7"/>
    <dbReference type="OMA" id="VMLHMPM"/>
    <dbReference type="OrthoDB" id="1927281at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10936">
        <property type="entry name" value="CE4_DAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006837">
        <property type="entry name" value="Divergent_DAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30105">
        <property type="entry name" value="PTHR30105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04748">
        <property type="entry name" value="Polysacc_deac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="320" mass="34959" checksum="7A34147FB3764852" modified="2005-11-22" version="1">MATSRNGKIKVNRKKGGRNSRPLVGFIILAVLVVAAVFLIDGLLNQKRPEKKPEPPKVVARHKLPPRESAAEKEPVVHEDYTATVVPPPTERHVRPRPAGSGNLAIIIDDMGKGMQEARSIIDIGVPVTFSIIPGLPKVRQVAQEAQRRGIEAMIHLPMEPKGYPERRLEENGLLLSQSNDEIVVRMNGYFKEVPQAVGANNHMGSAFTENKEKMAIVLRVLKEKGLFFVDSKTSAISVGESTAREMGLRTASRSVFLDNIQDVGYISKQIRQAASIARKRGSAIAICHPHPATIQALAAELPKLRDEGVTLVPASSLVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UR8</accession>
    <name>Q39UR8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7 8">Transcription elongation factor GreA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Transcript cleavage factor GreA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">greA</name>
        <name evidence="11" type="ordered locus">Gmet_1775</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7 8">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the GreA/GreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513328.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1775"/>
    <dbReference type="EnsemblBacteria" id="ABB32006">
        <property type="protein sequence ID" value="ABB32006"/>
        <property type="gene ID" value="Gmet_1775"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1775"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_2_0_7"/>
    <dbReference type="OMA" id="TWLTQEA"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006359">
        <property type="entry name" value="Tscrpt_elong_fac_GreA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01462">
        <property type="entry name" value="greA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="10">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="9">
        <location>
            <begin position="84"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="159" mass="17771" checksum="E6D21C9143DBA1C7" modified="2005-11-22" version="1">MSYSVPMTKESYDSLQEELKRLIREERPRVIQDIAEARSHGDLSENAEYDAAKNRQAFIEGRIQELQGKLARAHVVDLSGLKPDKVVFGATVTLYDTTSEEEVTYKIVGEEEADIKLGKISCTSPVGKALIGHKLDDSVKIKVPSGSVKEYEIIDIKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UT0</accession>
    <name>Q39UT0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1763</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513341.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31994">
        <property type="protein sequence ID" value="ABB31994"/>
        <property type="gene ID" value="Gmet_1763"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1763"/>
    <dbReference type="eggNOG" id="ENOG5033C1K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067281_1_0_7"/>
    <dbReference type="OMA" id="EYRTREY"/>
    <dbReference type="OrthoDB" id="2047098at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024447">
        <property type="entry name" value="YXWGXW_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12779">
        <property type="entry name" value="WXXGXW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223321" evidence="2">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="183" mass="21556" checksum="8927866946DB2991" modified="2005-11-22" version="1">MKKFLTVLPLFFATVSPSFAASDVGFDVNINVGNRSGVVIPAPPAVVVPAPRVVIEEPPLFIAPPRLGFYVGVDIPYDIFYISGRYYLWQDNYWYRAPSYGGPWTVVNHRNLPPGLRKHKLERIRYYRDDEYRVYSHEHDHYRGKHFKPGKEYKERYKEERKREKREYKHHGEEKGHGHGHDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UY5</accession>
    <name>Q39UY5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA--carboxylate coenzyme A transferase, beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1708</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514146.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1708"/>
    <dbReference type="EnsemblBacteria" id="ABB31939">
        <property type="protein sequence ID" value="ABB31939"/>
        <property type="gene ID" value="Gmet_1708"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1708"/>
    <dbReference type="eggNOG" id="COG2057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069088_0_0_7"/>
    <dbReference type="OMA" id="YWVGNHS"/>
    <dbReference type="OrthoDB" id="1380130at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="273" mass="29964" checksum="76F1BEF3CA38D9A2" modified="2005-11-22" version="1">MGREYANPEEYGLADLLCCAASREVQDNEIVFAGTGLPMVAIMLAQKTHAPNLKLIFEAGTLDGRPPAIPTSVGDARCEMGASRASGLYDAFSIAQRGYVDLGFLGGAEVDEYGNVNTTCIGDYLNPELRLTGSGGNPDINSFAKRTVFIMVHEKRRFTPNVSYITSPGWRVKKWPEGDFVHRRELYGAAYRGGPSAVISTAGVFRFDGETGRIYLDTCHPGKTPQEITEMCHFDLDISRVSGETLPPTREELHFIHDVLDPEQIFIPKVTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UY8</accession>
    <name>Q39UY8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain iron-sulfur cluster-binding oxidoreductase with cobalamin-binding-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1705</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514149.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1705"/>
    <dbReference type="EnsemblBacteria" id="ABB31936">
        <property type="protein sequence ID" value="ABB31936"/>
        <property type="gene ID" value="Gmet_1705"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1705"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_3_7"/>
    <dbReference type="OMA" id="WTFQAST"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="196"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="472" mass="53837" checksum="5A86F5F099B2EBE1" modified="2005-11-22" version="1">MKVLFIHPFGSNWLGTGTDITTIFNLMPPLGLLSIAAFLEARGIGTEVIDCYATPMPAETLVAEVIRRRPDVVGFSCTTSSFLEGYSIAERIKEKAPGITTVFGGAHACSVGVGLLDTFPAIDYLVIGEGEQTFFELVTNLDHGGSGIPGVGYRENGKGVISALREHIANLDDLPFPAYHRLPQFPKRYILPLFSYPKAPNTSIISSRGCPYQCSYCDRSVFSRGFRFNSPEYIVEHLKMLNRDYGIRHVFFYDDLFTTDRARVARFCELKERERLPVTYNCIARLEHVDAELLRLLKRSGCWQVNFGIESGDPEVIKKHRKFYGLDEVQRKLQLVRDTGMRVKGLFMVGLPGETEESIRRTIDYALALPLDEINVTKFTPFPGAPLYATIREQGEFDENWPLMNCLNFVFVPHGMTREQLEGLYNEFISRFYRRSRIHWGYTKMLWKSPHSVATFLRHLPEILAFELKQKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UZ0</accession>
    <name>Q39UZ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514151.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1703"/>
    <dbReference type="EnsemblBacteria" id="ABB31934">
        <property type="protein sequence ID" value="ABB31934"/>
        <property type="gene ID" value="Gmet_1703"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1703"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016488_0_0_7"/>
    <dbReference type="OrthoDB" id="39059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="487" mass="53092" checksum="0E0EB818146587E3" modified="2005-11-22" version="1">MQKKKILVVSLVVCAVVTLVFLSLPKKGVTATNTGWKVMVSNDLGIHCTCPDSSLISILPPANTLRAQVFNGSEIVTDPAKIRVEYSVPFADQLMTDPQYLTYLDNANKMYPTQEGWAKVSRTNPVSIVGTPLKSGKFVSKPEHNMWVAELIPVFPPKQPAGGEGTFKDAFGDIRQAFPKVTVTVKDAVTGAVLAQNTNTTTPVAFANCCTCHREIYKDKFGQYPANPLDSFRQTMLAPHDLKHNTDLLKLTQAGIPVRCSRCHMDPAVGGKTPGYPLSLYPAAAGLRLPIPAKTMTLSMALHQGHNLKNEFHTRYAALGFKESCEACHPGKETVGCMRGLHVNMTTASGKKLDFNCSDCHGDLNMRFATGQLLDPWSYRTLPRCSNCHKSNIGEWTNAQIEKYGKIQFGGAYLNSRGHADNKILCTSCHGSPHAEIPSKISWENIFYSTFNGGKAAPLGKCYGCHTDAGYSGWGRPPHGMSDNLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V77</accession>
    <name>Q39V77_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">BioD and DRTGG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511448.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1616"/>
    <dbReference type="EnsemblBacteria" id="ABB31847">
        <property type="protein sequence ID" value="ABB31847"/>
        <property type="gene ID" value="Gmet_1616"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1616"/>
    <dbReference type="eggNOG" id="COG0857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040984_1_0_7"/>
    <dbReference type="OMA" id="ASTQCLI"/>
    <dbReference type="OrthoDB" id="687829at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRTGG" evidence="1">
        <location>
            <begin position="229"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="363" mass="39608" checksum="3C0F5A2E0FF6E707" modified="2005-11-22" version="1">MAKRVFIGATGQNCGKTTMSVSLMHLARQKYDRVGFIKPIGPKIEGYNGLTVDMDAILMARTFGLEEDLPLMNPVSLHKNFTRDFLSGKLDCNVLKTKILEAFEILDKKYDFLIIEGAGHGGVGSVIGLSNACVAHTLNAPVIIVTDSGIGSSIDAVHLNLALYEKEDADVRMLLVNKLRADKRESILSFLGKGFPGRPLKISGGFNYSPILANPTLSHIGKLLNLPVHGDPDGQSRIIHHIHLGAASAQRVVDALQESTLIVITSSRDELIVTLSSLYHIPAFREKIVGLVIAGHIPASEISQQILDDSNIPYIRVHDSTANVFTTLMEDVAKITAEDQEKLNWIRANAENEIDFEAIDALL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V94</accession>
    <name>PLSX_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.274</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acyl-ACP phosphotransacylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-[acyl-carrier-protein]--phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-acyl-ACP acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsX</name>
        <name type="ordered locus">Gmet_1598</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a fatty acyl-[ACP] + phosphate = an acyl phosphate + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.274"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Probably interacts with PlsY.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Associated with the membrane possibly through PlsY.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PlsX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.274" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511467.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V94"/>
    <dbReference type="SMR" id="Q39V94"/>
    <dbReference type="STRING" id="269799.Gmet_1598"/>
    <dbReference type="EnsemblBacteria" id="ABB31830">
        <property type="protein sequence ID" value="ABB31830"/>
        <property type="gene ID" value="Gmet_1598"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1598"/>
    <dbReference type="eggNOG" id="COG0416">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039379_1_1_7"/>
    <dbReference type="OMA" id="HGKSNAR"/>
    <dbReference type="OrthoDB" id="631784at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043811">
        <property type="term" value="F:phosphate:acyl-[acyl carrier protein] acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00019">
        <property type="entry name" value="PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003664">
        <property type="entry name" value="FA_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012281">
        <property type="entry name" value="Phospholipid_synth_PlsX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30100">
        <property type="entry name" value="PTHR30100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02504">
        <property type="entry name" value="FA_synthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002465">
        <property type="entry name" value="Phsphlp_syn_PlsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00182">
        <property type="entry name" value="plsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000001766" description="Phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00019"/>
        </source>
    </evidence>
    <sequence length="345" mass="37117" checksum="3C98AACC52C616A9" modified="2005-11-22" version="1">MRVAVDAMGGDNAPSVEVEGAVVAAREFGIPITLVGDTERLRQELGKHNVQGLDILLHHASEVVGMHDAASDAVRRKKDSSVRVAFELLKTGAADAVVSAGNSGATMAAGMFVLKRLKGIDRPAIAQIFPTLRGKTLVLDVGGNVDCKPIHLVQFAIMGEVYARHVMGVEQPRVGLLSNGEEDSKGNELTRETNSILKNISFDYIGYVEGRDIFNGVVDVVVCDGFVGNVVLKLSEGLAEAVGKMLKDEIKQSFLSKLGYLFSRKAFSNFKKKVDYAEYGGAPLLGINGVAMICHGGSNVKAIKNAIVFANDYVRKGVNQRLAEKLETEFTMYMQQGNVRESVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VB2</accession>
    <name>Q39VB2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylmethionine-8-amino-7-oxononanoate aminotransferase</fullName>
            <ecNumber evidence="4">2.6.1.62</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">7,8-diamino-pelargonic acid aminotransferase</fullName>
            <shortName evidence="4">DAPA AT</shortName>
            <shortName evidence="4">DAPA aminotransferase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">7,8-diaminononanoate synthase</fullName>
            <shortName evidence="4">DANS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diaminopelargonic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">bioA</name>
        <name evidence="6" type="ordered locus">Gmet_1580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only aminotransferase known to utilize SAM as an amino donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(8S)-8-amino-7-oxononanoate + S-adenosyl-L-methionine = (7R,8S)-7,8-diammoniononanoate + S-adenosyl-4-methylsulfanyl-2-oxobutanoate</text>
            <dbReference type="Rhea" id="RHEA:16861"/>
            <dbReference type="ChEBI" id="CHEBI:16490"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="EC" id="2.6.1.62"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; biotin biosynthesis; 7,8-diaminononanoate from 8-amino-7-oxononanoate (SAM route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.62" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511485.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1580"/>
    <dbReference type="EnsemblBacteria" id="ABB31812">
        <property type="protein sequence ID" value="ABB31812"/>
        <property type="gene ID" value="Gmet_1580"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1580"/>
    <dbReference type="eggNOG" id="COG0161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_4_3_7"/>
    <dbReference type="OMA" id="VAVKMCL"/>
    <dbReference type="OrthoDB" id="478143at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00160"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004015">
        <property type="term" value="F:adenosylmethionine-8-amino-7-oxononanoate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00834">
        <property type="entry name" value="BioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005815">
        <property type="entry name" value="BioA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00508">
        <property type="entry name" value="bioA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="118"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="4">
        <location>
            <begin position="323"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Participates in the substrate recognition with KAPA and in a stacking interaction with the adenine ring of SAM" evidence="4">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="455" mass="50868" checksum="99E0550E570D5FBF" modified="2005-11-22" version="1">MNTSDTKTLREYDRAHVWHPFTQMKEWEESDPVVIVRGEGTWIVDSEGNRYLDGVAAIWTNVHGHCKREINEAIKAQVDTLEHSTLLGLANDKAVLLARRLVEIAPPGLCKVFYSDNGSTAVEISVKMAFQYWQHQGKPEKTKFISFKNAYHGDTIGAVSVGGIDLYHAVFRPLLFPTIQAPAPYCYRCEFGERDRANCGMRCLKELERLMEIHAHEVAGLVIEPLVQGAGGMIVQPDGFVRRVRELCDRYDILMIADEVAVGFGRTGAMFACEREGITPDIMALSKGITAGYLPLAATMTTQKIYDAFIGEYREMKTFFHGHTFTGNPIACAAALASLDLFENERLLDSLTNKIGYLAERLQALNEVRHVGEVRQCGMIAGIELVKDAETREPFPWEERVGIQVCLEARNRGIFLRPLGNIIVVFPPLSISLDELAFLMDGIEASIRAITELRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VE4</accession>
    <name>Q39VE4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511520.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1546"/>
    <dbReference type="EnsemblBacteria" id="ABB31780">
        <property type="protein sequence ID" value="ABB31780"/>
        <property type="gene ID" value="Gmet_1546"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1546"/>
    <dbReference type="eggNOG" id="ENOG5033BJ7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1710665_0_0_7"/>
    <dbReference type="OMA" id="KFWYTVK"/>
    <dbReference type="OrthoDB" id="1927017at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223315" evidence="1">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="17579" checksum="4588F680500B2193" modified="2005-11-22" version="1">MKKLPVVIAVATFALAAPLVSHAEMDHGSMKMDHGSMKMDHGGDVAHQEVVDGVKVTFKVMSMAEHMKGMKMEMPKGMKETHHIAVEFKDAKSGKAITEGEVKVKVQGPNKSEQVKDLMAMQGHFGADFDLSKKGKYGVMAKFKLADGKVRSAKFWYVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VF7</accession>
    <name>Q39VF7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, flavin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1533</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511533.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1533"/>
    <dbReference type="EnsemblBacteria" id="ABB31767">
        <property type="protein sequence ID" value="ABB31767"/>
        <property type="gene ID" value="Gmet_1533"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1533"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_3_7"/>
    <dbReference type="OMA" id="NRHGHIY"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="12"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="485" mass="52011" checksum="1D18C3077EE42C6B" modified="2005-11-22" version="1">MNPATSWDRTVDVVVIGYGGAGATAAIAAHDAGAATLVLESTPQGGGNTLVSFGGFISHNDPIKALAYVRALFDSSHSDRDDRLLRVFVEESAKTPDWLKTLDNEVAFQTYGGAGYPQLAGAEAIIRYVVKGANRGTTAFARNLWQLLSQAVERHRNIPVLTRTPAKRLVTGGNGEVTGVIAQSKGDEIAIQARRGVILTSGGYEFDPIMLKNSVKGSPLYSLGHPGNRGDGLRMAQKVGAALWHMNGVSCAFGFKAPEFDSALLMSIGTTGQIFVDRNGKRFVNESAVERQAGLLAVDYFDSHALSYPRIPFYLIFDENKRKREPVSGLIGLGSAGSRYSWSKDNRTEIDNGWIVQAETIADLARQLGISGLTLRDTIKQWNASVRAGKDTLFGREIKENSDLAMIHTGPFYAMEIYPSLANTQGGPRRNERAQIVDPFGDPIPGLYGAGELGSLWGLVYQGGGNIAECLAFGRIAGVSAAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VG7</accession>
    <name>Q39VG7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">(R)-benzylsuccinyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bbsG</name>
        <name evidence="9" type="ordered locus">Gmet_1523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511544.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1523"/>
    <dbReference type="EnsemblBacteria" id="ABB31757">
        <property type="protein sequence ID" value="ABB31757"/>
        <property type="gene ID" value="Gmet_1523"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1523"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_7"/>
    <dbReference type="OMA" id="GMSMFIV"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="BRENDA" id="1.3.8.3">
        <property type="organism ID" value="2414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="137"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="251"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="410" mass="46360" checksum="AAA9F28B4FEA7639" modified="2005-11-22" version="1">MDFSIPEEYMMLKESMREFVKRELMPLEKTLLERELSLWTEPGHLIPDEDHKRLMQKTKELGFWGLEVDEEFGGQGLGMLAKTLVVEELSKSLVGFSNHGFTLPPDAPNLYYLHECCGPRQREKYFVPYCNGDVDSAMACTEPGAGSDVSGLKTKAVKKGDKWVINGTKSFISKCDYDNVFFIVIAVTDPSASTKDRFTAFLIDREHPGVRIGKEIPVIGPMPTWDLILEDVEVDDDAILGDVGKAFIPLQNRFGVRRIELASSCTGMAERLIQMMIDQANTRITFGQPLAERGTIQNWIADSTMELEQVRWLLYYAAWKSDQGHKDLRIEGASVKVAATEMLTRVADRAIQIHGGLGVSHELGIEYVARHVRLWRIVEGPSEVHRWLVARQLLKEKKPYNPFIVAADEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VH2</accession>
    <name>Q39VH2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipoprotein release ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lolD-2</name>
        <name evidence="5" type="ordered locus">Gmet_1518</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511549.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1518"/>
    <dbReference type="EnsemblBacteria" id="ABB31752">
        <property type="protein sequence ID" value="ABB31752"/>
        <property type="gene ID" value="Gmet_1518"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1518"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="GRMPRWR"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="228" mass="24370" checksum="F3B7A2C64004AF36" modified="2005-11-22" version="1">MLKLHNVCKSYEGKSQVTALAGIDLAIGVGEMVAIMGPSGSGKSTLLNLMGGLDIPTSGEVLVSGKDLARSNEKERSLYRRSQISYIFQAYHLMPTLKVNQNVALPLHLAGVSSGEISRQVARVLQEVGLVARANHLPDELSGGERQRVAIARALVTGAPLLLADEPTGNLDSARGEEILNLLRSIHRERGTTIVMVTHDHHAASACDRLIKLRDGRVEGDSALGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VM4</accession>
    <name>Q39VM4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511604.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1466"/>
    <dbReference type="EnsemblBacteria" id="ABB31700">
        <property type="protein sequence ID" value="ABB31700"/>
        <property type="gene ID" value="Gmet_1466"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1466"/>
    <dbReference type="eggNOG" id="ENOG5033DGE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1989454_0_0_7"/>
    <dbReference type="OMA" id="HEINPNG"/>
    <dbReference type="OrthoDB" id="1765676at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="126" mass="14068" checksum="6389279B0B718155" modified="2005-11-22" version="1">MSDKPQVTFKYIFTYDYNPAYVNGAHGGVSPRGDLVVNFYLERPPLPNEITHEINPNGTVGAETAVEPDDFAQSLVRFVPSGIVLNHQTARELHHWLGEKVREMEAIEQHKSAMRTQQGEGDGPAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VN5</accession>
    <name>Q39VN5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1455</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511615.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1455"/>
    <dbReference type="EnsemblBacteria" id="ABB31689">
        <property type="protein sequence ID" value="ABB31689"/>
        <property type="gene ID" value="Gmet_1455"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1455"/>
    <dbReference type="HOGENOM" id="CLU_1033497_0_0_7"/>
    <dbReference type="OMA" id="QWEIVID"/>
    <dbReference type="OrthoDB" id="1986521at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="269" mass="28656" checksum="B5E944718D0BC7C8" modified="2005-11-22" version="1">MYRYARKYAFTVVAVGLVAGCAAPERGGLIKAGDPVRVTYTCFDGTGALAATNVREAAGNNGVKKGPLFLPSRDYSPLQLTAGTRPEAKDRGVDDELAAGLAGAVVGKGVGEVASVELAGGPLEGLSGGDRYLKMATVRKRAKELRLGREEYLTRTGREPEKGRRFVLDPALPGIVEEVTDKEVVIRFPLPDGGVVQTPFGPGTVRDGGDQWEIVIDAAVGRIVRSGPLAGRISDVNERFFTIDYGYPFGGESLRCDVKAERSEQVGKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VS1</accession>
    <name>SURE_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5'-nucleotidase SurE</fullName>
            <ecNumber evidence="1">3.1.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside 5'-monophosphate phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">surE</name>
        <name type="ordered locus">Gmet_1419</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate</text>
            <dbReference type="Rhea" id="RHEA:12484"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18254"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
            <dbReference type="EC" id="3.1.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SurE nucleotidase family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511648.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VS1"/>
    <dbReference type="SMR" id="Q39VS1"/>
    <dbReference type="STRING" id="269799.Gmet_1419"/>
    <dbReference type="EnsemblBacteria" id="ABB31653">
        <property type="protein sequence ID" value="ABB31653"/>
        <property type="gene ID" value="Gmet_1419"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1419"/>
    <dbReference type="eggNOG" id="COG0496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045192_1_2_7"/>
    <dbReference type="OMA" id="DCVHIAL"/>
    <dbReference type="OrthoDB" id="1909278at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106411">
        <property type="term" value="F:XMP 5'-nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00060">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030048">
        <property type="entry name" value="SurE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30457">
        <property type="entry name" value="PTHR30457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SSF64167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000235616" description="5'-nucleotidase SurE">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00060"/>
        </source>
    </evidence>
    <sequence length="252" mass="26884" checksum="AEA718AFCD0F0601" modified="2005-11-22" version="1">MKILVTNDDGVRAPGIRSLAEALRNIGDVVVVAPDRERSAVGHALTLHHPLRASEIRPAVFAVDGTPTDCVNLGIHTLLGSRPDIVVSGVNCGGNMGDDITYSGTVSAAMEATLMGIPALAVSLATSGRGDNYAVASAFAARLVRIVSERGLPPDTLLNVNVPDLPLEKLGGAVVTIQGKRDYEGKIVTKTDPRGRNYYWIGNGSLQFRDLEGTDYYAVKRGLVSITPLHLDLTNYASLTTLKTWDFAEMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VV4</accession>
    <name>Q39VV4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease R</fullName>
            <shortName evidence="6">RNase R</shortName>
            <ecNumber evidence="6">3.1.13.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">rnr</name>
        <name evidence="9" type="ordered locus">Gmet_1386</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.13.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RNR ribonuclease family. RNase R subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513122.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1386"/>
    <dbReference type="EnsemblBacteria" id="ABB31620">
        <property type="protein sequence ID" value="ABB31620"/>
        <property type="gene ID" value="Gmet_1386"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1386"/>
    <dbReference type="eggNOG" id="COG0557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002333_7_0_7"/>
    <dbReference type="OMA" id="DWYEYRS"/>
    <dbReference type="OrthoDB" id="1602988at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008859">
        <property type="term" value="F:exoribonuclease II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01895">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040476">
        <property type="entry name" value="CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013223">
        <property type="entry name" value="RNase_B_OB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004476">
        <property type="entry name" value="RNase_II/RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011805">
        <property type="entry name" value="RNase_R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17876">
        <property type="entry name" value="CSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08206">
        <property type="entry name" value="OB_RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00358">
        <property type="entry name" value="3_prime_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02063">
        <property type="entry name" value="RNase_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="S1 motif" evidence="8">
        <location>
            <begin position="622"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="708"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="725"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="759" mass="85305" checksum="08A8DFCC5F394A23" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VW1</accession>
    <name>Q39VW1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1379</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513129.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1379"/>
    <dbReference type="EnsemblBacteria" id="ABB31613">
        <property type="protein sequence ID" value="ABB31613"/>
        <property type="gene ID" value="Gmet_1379"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1379"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_133_4_7"/>
    <dbReference type="OMA" id="QCALGEM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029150">
        <property type="entry name" value="dCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14827">
        <property type="entry name" value="dCache_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="350"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="579" mass="66721" checksum="5525418272830D5E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VZ9</accession>
    <name>Q39VZ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin, PIN family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31575.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513166.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1340"/>
    <dbReference type="EnsemblBacteria" id="ABB31575">
        <property type="protein sequence ID" value="ABB31575"/>
        <property type="gene ID" value="Gmet_1340"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1340"/>
    <dbReference type="eggNOG" id="COG5611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121449_0_0_7"/>
    <dbReference type="OMA" id="TNILVRY"/>
    <dbReference type="OrthoDB" id="1842663at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="1">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31575.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="129" mass="14468" checksum="EBEB04C8237C07A2" modified="2012-10-31" version="2">MIAVDTNILVRYVTNDDPLQARRALAILARQEDIFIPKTVLLETEWVLRAVYELPVESILKALLHILGLPNVVAENPEEVSLALDYYSRRLDFADALHLASSCHADSFFSFDAAFVKRGKKIGARVEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W25</accession>
    <name>Q39W25_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Polbeta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1313</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514784.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1313"/>
    <dbReference type="EnsemblBacteria" id="ABB31549">
        <property type="protein sequence ID" value="ABB31549"/>
        <property type="gene ID" value="Gmet_1313"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1313"/>
    <dbReference type="eggNOG" id="ENOG5032X6R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1980604_0_0_7"/>
    <dbReference type="OrthoDB" id="2025713at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="133" mass="14975" checksum="E816095E06282724" modified="2005-11-22" version="1">MRSDLSASVVDTLRAALEDEPLLELAVLIGSGATGRRGLESDWDIAIQWDRDVSLLGHLGRTESLRRRLASILGITEDTVDLIDLPSARLAMRAVVAEEGIPLKGEDGLPWQHFLRRTWRDLEDYYWEQTYAA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W70</accession>
    <name>LEUC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-isopropylmalate dehydratase large subunit</fullName>
            <ecNumber evidence="1">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Alpha-IPM isomerase</fullName>
            <shortName evidence="1">IPMI</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuC</name>
        <name type="ordered locus">Gmet_1268</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of LeuC and LeuD.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512099.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W70"/>
    <dbReference type="SMR" id="Q39W70"/>
    <dbReference type="STRING" id="269799.Gmet_1268"/>
    <dbReference type="EnsemblBacteria" id="ABB31504">
        <property type="protein sequence ID" value="ABB31504"/>
        <property type="gene ID" value="Gmet_1268"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1268"/>
    <dbReference type="eggNOG" id="COG0065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_3_4_7"/>
    <dbReference type="OMA" id="CNMSIEM"/>
    <dbReference type="OrthoDB" id="749418at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01583">
        <property type="entry name" value="IPMI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01027">
        <property type="entry name" value="LeuC_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011826">
        <property type="entry name" value="HAcnase/IPMdehydase_lsu_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006251">
        <property type="entry name" value="Homoacnase/IPMdehydase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033941">
        <property type="entry name" value="IPMI_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01343">
        <property type="entry name" value="hacA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02086">
        <property type="entry name" value="IPMI_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000063648" description="3-isopropylmalate dehydratase large subunit">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01027"/>
        </source>
    </evidence>
    <sequence length="427" mass="46164" checksum="8560F437D1CD5082" modified="2005-11-22" version="1">MGKTTAEKIFASHLVDEPFSGTKVLRLDVVMCHEITTPIAIADLMARGKDRVFDPTKIKAVIDHVTPSKDSKTATQAKMLRDWARRHAIKDFFDVGHNGVCHALFPEKGYIRPGYTVIMGDSHTCTHGAFGAFAAGVGTTDLEVGILKGVCAFREPKSIRINLNGTLPKGVYAKDVILYVIGQLGVNGATDRVMEFRGPVVDAMTMESRMTLCNMAIEAGGTSGICMPDMVTVEYLWPFIENEYPSKEAALAEFSTWRSDDDAVYERVLDFDVSVLEPIVTFGYKPDQVKPISEIAGSPVDQVYLGSCTNGRLEDLRIAARILKGKKIAPSVRGILSPATPKIYKDAMAEGLIDIFMEAGFCVTNPTCGACLGMSNGVLAEGEVCASTTNRNFMGRMGKGGMVHLMSPATSAATAIEGVIADPRKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W77</accession>
    <name>Q39W77_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetolactate synthase small subunit</fullName>
            <shortName evidence="8">AHAS</shortName>
            <shortName evidence="8">ALS</shortName>
            <ecNumber evidence="8">2.2.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetohydroxy-acid synthase small subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ilvN</name>
        <name evidence="10" type="ordered locus">Gmet_1261</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 8">Dimer of large and small chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the acetolactate synthase small subunit family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512106.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1261"/>
    <dbReference type="EnsemblBacteria" id="ABB31497">
        <property type="protein sequence ID" value="ABB31497"/>
        <property type="gene ID" value="Gmet_1261"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1261"/>
    <dbReference type="eggNOG" id="COG0440">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055003_1_3_7"/>
    <dbReference type="OMA" id="EPYGIKE"/>
    <dbReference type="OrthoDB" id="1500398at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990610">
        <property type="term" value="F:acetolactate synthase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04878">
        <property type="entry name" value="ACT_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004789">
        <property type="entry name" value="Acetalactate_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019455">
        <property type="entry name" value="Acetolactate_synth_ssu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039557">
        <property type="entry name" value="AHAS_ACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30239">
        <property type="entry name" value="PTHR30239"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10369">
        <property type="entry name" value="ALS_ss_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00119">
        <property type="entry name" value="acolac_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="163" mass="17725" checksum="3B45948CC0A8115D" modified="2005-11-22" version="1">MRHTITVLVENEFGVLSRVAGLFSGRGFNIDSLSVAPTNDETISRMTIVTRGDDQILEQISKQLNKLIDVIKVIDFTDGEVVEREMALIKVTAEDSARAEVLRIADIFRAKIIDVTPKSFTIEATGAPAKIDAILELLRPLGLKELVRTGPVAIGRGAKALKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WA5</accession>
    <name>Q39WA5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365785.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1233"/>
    <dbReference type="EnsemblBacteria" id="ABB31469">
        <property type="protein sequence ID" value="ABB31469"/>
        <property type="gene ID" value="Gmet_1233"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1233"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007251_3_0_7"/>
    <dbReference type="OMA" id="EHCGDIY"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223205" evidence="2">
        <location>
            <begin position="21"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="489"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="523"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="573" mass="64769" checksum="6603DDA7FB814664" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WC2</accession>
    <name>Q39WC2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase III subunit alpha</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">dnaE</name>
        <name evidence="10" type="ordered locus">Gmet_1215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512155.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1215"/>
    <dbReference type="EnsemblBacteria" id="ABB31452">
        <property type="protein sequence ID" value="ABB31452"/>
        <property type="gene ID" value="Gmet_1215"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1215"/>
    <dbReference type="eggNOG" id="COG0587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001600_0_2_7"/>
    <dbReference type="OMA" id="NECRRMG"/>
    <dbReference type="OrthoDB" id="561611at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011708">
        <property type="entry name" value="DNA_pol3_alpha_NTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041931">
        <property type="entry name" value="DNA_pol3_alpha_thumb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040982">
        <property type="entry name" value="DNA_pol3_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029460">
        <property type="entry name" value="DNAPol_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004805">
        <property type="entry name" value="PolC_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32294">
        <property type="entry name" value="PTHR32294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07733">
        <property type="entry name" value="DNA_pol3_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17657">
        <property type="entry name" value="DNA_pol3_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14579">
        <property type="entry name" value="HHH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00594">
        <property type="entry name" value="polc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="9">
        <location>
            <begin position="4"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1155" mass="128692" checksum="5CE2306E0F38CD99" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WC5</accession>
    <name>Q39WC5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512158.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1212"/>
    <dbReference type="EnsemblBacteria" id="ABB31449">
        <property type="protein sequence ID" value="ABB31449"/>
        <property type="gene ID" value="Gmet_1212"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1212"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_7"/>
    <dbReference type="OMA" id="ANGHAGW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="87"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="163"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="243"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="458" mass="51298" checksum="E0C5C8A1697348A6" modified="2005-11-22" version="1">MPYRRQDTLPEIGRSDSEATRWSAAKIVVVYLSFGIVWMLATVTWMGFGAAMVWQALFILLSAGLVAILVRHLTGELERIRSLLRDGERRYYQLAELLPQPVYEADPDGRITFANRKAFTAFGFTEEDFAQGINILKAVAPHDQDRAHQSRVGLLAGVHDPGTATQYTVRRKDGSTFPAIVCTAPLIRRGNAVGTCGVVADISEQKQREAEISRLNLELEQRVQERTAELASALKHMESFSYSISHDLRAPLCAIEGFSRVLIEDFGEQLPPRMLLYLQRISHNVHRMASLIDDILVFSRYSLSPLQKRPVQIADLVRAILDELLNGQDDRRVQVTVGDLPPCESDPTLLRQVLFNLLDNALKYSRYRDPAIIEVNAVMDGPVPVYFVRDNGAGFDMEYVHKLFSVFERLHGREEFEGTGVGLAIVQNIIQRHGGDVWAEGAVGQGSTFYFTLPSAPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WG1</accession>
    <name>Q39WG1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTPase-activating protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513441.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1175"/>
    <dbReference type="EnsemblBacteria" id="ABB31413">
        <property type="protein sequence ID" value="ABB31413"/>
        <property type="gene ID" value="Gmet_1175"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1175"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161433_1_0_7"/>
    <dbReference type="OMA" id="WGILLAH"/>
    <dbReference type="OrthoDB" id="1902474at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03259">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="4"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="119" mass="13138" checksum="37E6325E7C6AE9FE" modified="2005-11-22" version="1">MSFKAILTQLVQSVPGATGAIIADWEGETVDHVALRDDYELKITAAHLGIILTRMKELQGRLSADPVREAVITLADQRVILGPIGDDYLLVLTLDREAIAGWAMVKFEHVQAILLKEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WJ9</accession>
    <name>Q39WJ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513401.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1137"/>
    <dbReference type="EnsemblBacteria" id="ABB31375">
        <property type="protein sequence ID" value="ABB31375"/>
        <property type="gene ID" value="Gmet_1137"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1137"/>
    <dbReference type="eggNOG" id="COG3500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_718939_0_0_7"/>
    <dbReference type="OMA" id="HALNVNM"/>
    <dbReference type="OrthoDB" id="1278199at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="381" mass="41352" checksum="2C9E938ECE8683B7" modified="2005-11-22" version="1">MILDFLTSKRREPAECIILVGSAGLEITDLYPFLTEVTVDAGRAEPTVATITFESRRDEQGRWLVQDDGRLAPWEPIVIEAAFGSATEEVMRGYIREVRADYPEDAGSARVIVECRDDSLALDREHVREVWGGDAPTTDMVIVPAILGKYGLSPDPANGSGQTGLVINQDGTDIEFLRSRAEANGYDLLFRGGMVYFGPMRLDAEPQETIMVYAGEATSAYRFSVRDDGHQADRVAFDRAETAGSGTVSETVDPDLPLLGNEAATGAGSGLPDFAWRMSRQGEMSEDEWRARAQRRANDLSLRVKGEGELDGSLYGHVLRVGEPVGVDGVGDRYGGIWFVDTVNHRFSTEGYRQSFNLLRNAYGDNLGSGAGGVLAGVLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WL3</accession>
    <name>Q39WL3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">2-methylcitrate dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.79</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prpD</name>
        <name evidence="9" type="ordered locus">Gmet_1123</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3S)-2-methylcitrate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17725"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="4.2.1.79"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PrpD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.79" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513387.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1123"/>
    <dbReference type="EnsemblBacteria" id="ABB31361">
        <property type="protein sequence ID" value="ABB31361"/>
        <property type="gene ID" value="Gmet_1123"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1123"/>
    <dbReference type="eggNOG" id="COG2079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021803_1_0_7"/>
    <dbReference type="OMA" id="ECTKHLG"/>
    <dbReference type="OrthoDB" id="688128at2"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="PTHR16943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="SSF103378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE_PrpD" evidence="7">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE_PrpD_C" evidence="8">
        <location>
            <begin position="288"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="481" mass="53800" checksum="23A9C463BA9F0936" modified="2005-11-22" version="1">MSTTADVNVRPAPDQVLVDIAEYVTGYRVTSHEARETARYSLIDALGCGMLALTFPECTKLLGPIVPGIVVPLGARVPGTRYELDPVKAAFDIGCIIRWLDFNDTWLAAEWGHPSDNLGAILAVADHLSRRNVAEGNAPVTMGEVLTCMVMAHEIQGCLALENSFNRVGLDHVLLVKVASTAVVMRLLGGTKEQIIDALSQAWVDGQSLRTYRHAPNAGSRKSWAAGDAVSRAVRLALMTLQGEKGYPSALTAPTWGFYDVSFKGRPFRFQRPFGTYVMENVLFKISYPAEFHAQTAVEAAVKLHPQVRERLSDIEKIVITTHESAIRIISKTGKLHNPADRDHCLQYMTAIGLIFGNLTADHYEEKAAADPRIDPLRERMEVVEEPRYSREYLEPDKRSIANAVQVFFRDGSCTERVEVEYPLGHRRRRAEGIPLLLEKFRANLSARFPEERLRRIVACCQDQQRLENTPVNEFMELFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WN6</accession>
    <name>Q39WN6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513754.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1098"/>
    <dbReference type="EnsemblBacteria" id="ABB31338">
        <property type="protein sequence ID" value="ABB31338"/>
        <property type="gene ID" value="Gmet_1098"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1098"/>
    <dbReference type="eggNOG" id="ENOG502ZU8H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1383214_0_0_7"/>
    <dbReference type="OMA" id="CPIKHAR"/>
    <dbReference type="OrthoDB" id="1751906at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="204" mass="24441" checksum="4DE2102B4987E360" modified="2005-11-22" version="1">MDYRINELIERIKALEEELETEFEKKREEFHLIVEEKRVRFAREVVEQQRRLKTGALRYIAEAQPLALLSAPIIYAGFIPFLLLDFFITTYQAICFPIYGIPKVRRRDYLVFDREDLPYLNVIEKFNCFYCSYANGLATYLREVAARTEQYWCPIKHARRILAPHTRYSRFFEYGDAESFRKGLERLRAEFERNNGKNGKKGER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WQ9</accession>
    <name>CHEB1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-glutamate methylesterase/protein-glutamine glutaminase 1</fullName>
            <ecNumber evidence="1">3.1.1.61</ecNumber>
            <ecNumber evidence="1">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cheB1</name>
        <name type="ordered locus">Gmet_1075</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="1"/>
    <dbReference type="EC" id="3.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513731.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39WQ9"/>
    <dbReference type="SMR" id="Q39WQ9"/>
    <dbReference type="STRING" id="269799.Gmet_1075"/>
    <dbReference type="PRIDE" id="Q39WQ9"/>
    <dbReference type="EnsemblBacteria" id="ABB31315">
        <property type="protein sequence ID" value="ABB31315"/>
        <property type="gene ID" value="Gmet_1075"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1075"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_7"/>
    <dbReference type="OMA" id="MLEMHRA"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264276" description="Protein-glutamate methylesterase/protein-glutamine glutaminase 1">
        <location>
            <begin position="1"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="1">
        <location>
            <begin position="164"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <sequence length="363" mass="39686" checksum="5C8D858CA230EB40" modified="2005-11-22" version="1">MSTQPIKVLIVDDSALIRSLLTDIINSQTDMEVVGVAPDPLVAREKIKALNPDVLTLDVEMPRMDGLVFLEKLMRLRPMPVLMVSSLTEKSSFLTLRALELGAVDFVTKPKIDISRGMQEYAREITDKLRVAAKARVRQPPHVHLSVERKNTADAVLPMEHRTFSSTEKIIVIGASTGGTEALKSFLVAMPADSPGILITQHMPEAFTRTFAQRLNSLCRISVKEAEHGERILPGHAYVAPGNRHLLLARSGANYVVELSDGPPVSRHRPSVDVLFRSAANRAGRNAVGIIMTGMGDDGAAGMLEMREAGAYTFAQDEKSCVVFGMPKEAIARGGVDEVAPLGEMPRRLFGWLESQGNRAFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WR3</accession>
    <name>Q39WR3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bro-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1071</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513727.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1071"/>
    <dbReference type="EnsemblBacteria" id="ABB31311">
        <property type="protein sequence ID" value="ABB31311"/>
        <property type="gene ID" value="Gmet_1071"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1071"/>
    <dbReference type="eggNOG" id="COG3617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1029133_0_0_7"/>
    <dbReference type="OMA" id="PEYAILT"/>
    <dbReference type="OrthoDB" id="872571at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003497">
        <property type="entry name" value="BRO_N_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02498">
        <property type="entry name" value="Bro-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01040">
        <property type="entry name" value="Bro-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bro-N" evidence="1">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="278" mass="31885" checksum="C9A96A45E9629BB5" modified="2005-11-22" version="1">METKLVVFQSKEIRRLLVDNVWFFAVVDVIAALTDSDKPRDYWYRMKKRELDASGIELSTFCRQLKLESSDGKKYLTEMASTEGLFRIIQSIPSPKAEPFKRWLAKVGYERVQEIEDPELATKRIRELYKAKGYSEAWVEKRMRGIAIRAELTEEWKNRGVKGEPEYAILTAEISKAAFGMTPGEYKQFKGLGRENLRDHMTDLELIFSMLGEAATTEIARKQDAQGFPENKVAAHKGGRIAGEAREKLEVETGERVVTSENFLVEPESRKRLKGKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WT7</accession>
    <name>Q39WT7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional repressor, HgtR-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513220.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1047"/>
    <dbReference type="EnsemblBacteria" id="ABB31287">
        <property type="protein sequence ID" value="ABB31287"/>
        <property type="gene ID" value="Gmet_1047"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1047"/>
    <dbReference type="HOGENOM" id="CLU_2682546_0_0_7"/>
    <dbReference type="OrthoDB" id="2187366at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RHH_1" evidence="1">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="74" mass="8420" checksum="A367B7653E92EB5D" modified="2005-11-22" version="1">MGKPVSVNPKPTVISVRVTDDQMEEIRRLMEKKKMSASDIMREAFCSFVENAEQRRMDAIRAAALKYTEARGEA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X78</accession>
    <name>SPEA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Biosynthetic arginine decarboxylase</fullName>
            <shortName evidence="1">ADC</shortName>
            <ecNumber evidence="1">4.1.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">speA</name>
        <name type="ordered locus">Gmet_0904</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the biosynthesis of agmatine from arginine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-arginine = agmatine + CO2</text>
            <dbReference type="Rhea" id="RHEA:17641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:58145"/>
            <dbReference type="EC" id="4.1.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amine and polyamine biosynthesis; agmatine biosynthesis; agmatine from L-arginine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.19" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513934.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X78"/>
    <dbReference type="SMR" id="Q39X78"/>
    <dbReference type="STRING" id="269799.Gmet_0904"/>
    <dbReference type="EnsemblBacteria" id="ABB31146">
        <property type="protein sequence ID" value="ABB31146"/>
        <property type="gene ID" value="Gmet_0904"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0904"/>
    <dbReference type="eggNOG" id="COG1166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027243_1_0_7"/>
    <dbReference type="OMA" id="AVEYTQH"/>
    <dbReference type="OrthoDB" id="164471at2"/>
    <dbReference type="UniPathway" id="UPA00186">
        <property type="reaction ID" value="UER00284"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008792">
        <property type="term" value="F:arginine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006527">
        <property type="term" value="P:arginine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06830">
        <property type="entry name" value="PLPDE_III_ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01417">
        <property type="entry name" value="SpeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040634">
        <property type="entry name" value="Arg_decarb_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041128">
        <property type="entry name" value="Arg_decarbox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002985">
        <property type="entry name" value="Arg_decrbxlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43295">
        <property type="entry name" value="PTHR43295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17810">
        <property type="entry name" value="Arg_decarb_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17944">
        <property type="entry name" value="Arg_decarbox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001336">
        <property type="entry name" value="Arg_decrbxlase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01180">
        <property type="entry name" value="ARGDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01273">
        <property type="entry name" value="speA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="chain" id="PRO_1000068490" description="Biosynthetic arginine decarboxylase">
        <location>
            <begin position="1"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="282"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01417"/>
        </source>
    </evidence>
    <sequence length="635" mass="71521" checksum="689186DAE924266B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XB7</accession>
    <name>Q39XB7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytidylate kinase</fullName>
            <shortName evidence="8">CK</shortName>
            <ecNumber evidence="8">2.7.4.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cytidine monophosphate kinase</fullName>
            <shortName evidence="8">CMP kinase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">cmk</name>
        <name evidence="10" type="ordered locus">Gmet_0865</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + CMP = ADP + CDP</text>
            <dbReference type="Rhea" id="RHEA:11600"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>ATP + dCMP = ADP + dCDP</text>
            <dbReference type="Rhea" id="RHEA:25094"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57566"/>
            <dbReference type="ChEBI" id="CHEBI:58593"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.25"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cytidylate kinase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.25" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0865"/>
    <dbReference type="EnsemblBacteria" id="ABB31107">
        <property type="protein sequence ID" value="ABB31107"/>
        <property type="gene ID" value="Gmet_0865"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0865"/>
    <dbReference type="eggNOG" id="COG0283">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079959_0_2_7"/>
    <dbReference type="OMA" id="RAITWWM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036430">
        <property type="term" value="F:CMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036431">
        <property type="term" value="F:dCMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006220">
        <property type="term" value="P:pyrimidine nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02020">
        <property type="entry name" value="CMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00238">
        <property type="entry name" value="Cytidyl_kinase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003136">
        <property type="entry name" value="Cytidylate_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011994">
        <property type="entry name" value="Cytidylate_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02224">
        <property type="entry name" value="Cytidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00017">
        <property type="entry name" value="cmk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidylate_kin" evidence="9">
        <location>
            <begin position="8"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="12"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="232" mass="25193" checksum="3F1A948A7A1D6E10" modified="2005-11-22" version="1">MGRRGLIIAIDGPSGAGKSTITKRLADRLGYVHIDTGAMFRAVALVAKRAGLDGADDESLERLCRGIEIDFFRNNGCCRVIVNGEDVTEAIRTPDISSLTSAISARKVVRDFLLTLQRRMGNEGGVILEGRDIGTVVFPNADVKFFLSASVEERGRRRWLELTGKGVNVTLEDTVSAVALRDKQDSGREHAPLRRADDAIDVDSTGLSIDQVIAIMEGMVREKEQAHSVCAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XI8</accession>
    <name>Q39XI8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Small ribosomal subunit biogenesis GTPase RsgA</fullName>
            <ecNumber evidence="3">3.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">rsgA</name>
        <name evidence="7" type="ordered locus">Gmet_0794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513539.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0794"/>
    <dbReference type="EnsemblBacteria" id="ABB31036">
        <property type="protein sequence ID" value="ABB31036"/>
        <property type="gene ID" value="Gmet_0794"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0794"/>
    <dbReference type="eggNOG" id="COG1162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033617_0_1_7"/>
    <dbReference type="OMA" id="RFHDCAH"/>
    <dbReference type="OrthoDB" id="908180at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01854">
        <property type="entry name" value="YjeQ_EngC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01820">
        <property type="entry name" value="GTPase_RsgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004881">
        <property type="entry name" value="Ribosome_biogen_GTPase_RsgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010914">
        <property type="entry name" value="RsgA_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32120">
        <property type="entry name" value="PTHR32120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03193">
        <property type="entry name" value="RsgA_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00157">
        <property type="entry name" value="TIGR00157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50936">
        <property type="entry name" value="ENGC_GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CP-type G" evidence="6">
        <location>
            <begin position="103"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ENGC_GTPASE" evidence="5">
        <location>
            <begin position="111"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="202"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="358" mass="38196" checksum="3074F197F641968E" modified="2005-11-22" version="1">MDELKVLGWSDWFAETGPEGGADPGTVARVTAELRGEYRLRAAAGEFPAQLAPRLRKGAADRLDRPMVGDWVVIEPVNGGSEVTIHDILPRRTLLARRGAGGGGEVQPIAANVDLVFIVMGLDGNYNPRRLERYLVAARESGAEPVVILSKADLCPDAAERVAEAAALGPGVRVVPVSSLAGEGVSAVREVLASGVTACFVGSSGVGKSTLVNRLAGEEVMATGAVRERDAKGRHTTTHRQMILLPCGAIVIDTPGMREFGLWQAGEGLDASFPEIAELAKQCRFHDCSHAHEPGCAVRDALAGGEIDQGRYASYLKLRKEDEAAAARDDVAARQERKGKERRIAKGRRVVLRKKGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XQ4</accession>
    <name>Q39XQ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514445.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0728"/>
    <dbReference type="EnsemblBacteria" id="ABB30970">
        <property type="protein sequence ID" value="ABB30970"/>
        <property type="gene ID" value="Gmet_0728"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0728"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1765416_0_0_7"/>
    <dbReference type="OMA" id="RIFRMGL"/>
    <dbReference type="OrthoDB" id="1725187at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="16847" checksum="477EA036A1C1B999" modified="2005-11-22" version="1">MAGTNVEELIARGIRAVNSGKTSLALECFEEAVERRNTPANWSYLAFCLAKERRQFDRAIQLCQEAIRKDPQNAVHYLNLGRVYLQAGSTKDAIHVFRQGLLYESNSHIEAELRKIGLRKPPVVGFLRRDHPINKYLGIVMKKLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XU3</accession>
    <name>Q39XU3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514080.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0689"/>
    <dbReference type="EnsemblBacteria" id="ABB30931">
        <property type="protein sequence ID" value="ABB30931"/>
        <property type="gene ID" value="Gmet_0689"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0689"/>
    <dbReference type="eggNOG" id="COG4705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070268_0_0_7"/>
    <dbReference type="OMA" id="SRVALFW"/>
    <dbReference type="OrthoDB" id="1466669at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007136">
        <property type="entry name" value="DUF347"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03988">
        <property type="entry name" value="DUF347"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="256" mass="27522" checksum="D3525E741547098D" modified="2005-11-22" version="1">MNTTPEQTTRQLLIKVPQVTIIFWIIKIAATTLGETGGDAVSMSMNLGYLVGTGIFAAIFAVAVTAQVRADRFHPFLYWSTIIATTTVGTTLADFADRSLGIGYAGGASLLFALLMGSLLVWYRSMGSVSVDTVRTRKAEVFYWVTIMFSQTLGTALGDWTADTAGLGYTGGALVFTILLAGVVAAYYWTRISRTALFWTAFILTRPLGAVVGDLLDKPVSAGGFGLNRYSASAVLFSFILLGLYALPQRAAERNH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y05</accession>
    <name>RL4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplD</name>
        <name type="ordered locus">Gmet_0627</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms part of the polypeptide exit tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30869.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514238.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y05"/>
    <dbReference type="SMR" id="Q39Y05"/>
    <dbReference type="STRING" id="269799.Gmet_0627"/>
    <dbReference type="EnsemblBacteria" id="ABB30869">
        <property type="protein sequence ID" value="ABB30869"/>
        <property type="gene ID" value="Gmet_0627"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0627"/>
    <dbReference type="eggNOG" id="COG0088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041575_5_2_7"/>
    <dbReference type="OMA" id="PQVHILE"/>
    <dbReference type="OrthoDB" id="1572673at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01328_B">
        <property type="entry name" value="Ribosomal_L4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_L4/L1e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_L4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4/L1e"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="PTHR10746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="SSF52166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000242379" description="50S ribosomal protein L4">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01328"/>
        </source>
    </evidence>
    <sequence length="207" mass="22389" checksum="F6C65528AD225E4B" modified="2013-07-24" version="2">MATIDVFDINKNKVGEMDLSDAVFNGDVREYLIHEAVKVQLANRRAGTVGVKNRAAVSGGGKKPFKQKGTGQARQGCIRAPHYVGGGVAFGPQAKTYALSMNKKARKAAVRSALSMLFKENKLSVLDCLSLPSISTKGFVGVLKTFDVTKTLVIIDEANTNLELSARNVKDVKVLKAEHLNVFDIVKFNNIILTQSAVRKIEGALQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y81</accession>
    <name>Q39Y81_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512246.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0550"/>
    <dbReference type="EnsemblBacteria" id="ABB30793">
        <property type="protein sequence ID" value="ABB30793"/>
        <property type="gene ID" value="Gmet_0550"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0550"/>
    <dbReference type="eggNOG" id="ENOG5033KN7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094189_1_0_7"/>
    <dbReference type="OMA" id="NNPHIIT"/>
    <dbReference type="OrthoDB" id="1915225at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="139" mass="15365" checksum="C4024782039BBE7F" modified="2005-11-22" version="1">MVVGFNHNVMYKGEVFHVQTEDSGIANPHIVTLIYREGTIIAARKTSYADIIKVDNLERVVEELMKEQHKGMLRRLKNGEFDAKAFPPSRIAPAAQPAPKPALAPQPASVAPPKPPTKPQEKPSSLDDVILDFLLTDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YH4</accession>
    <name>Q39YH4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-2-acetamido-2, 6-dideoxy-beta-L-arabino-4-hexulose 4-aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365672.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0457"/>
    <dbReference type="EnsemblBacteria" id="ABB30700">
        <property type="protein sequence ID" value="ABB30700"/>
        <property type="gene ID" value="Gmet_0457"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0457"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_0_3_7"/>
    <dbReference type="OMA" id="QVHYKPI"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020026">
        <property type="entry name" value="PseC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03588">
        <property type="entry name" value="PseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="398" mass="43990" checksum="A66AF899B0BE75FD" modified="2005-11-22" version="1">MRSAPIPYGRQSISPADIQAVVDVLNSDWLTQGPTVERFEQTVAGYCGTAHGVAVNSATSALHMACLAAGLGPGDILWTSPNTFVASANCGLYCGATVDFVDIDPRTYNMSAERLEEKLERAAREGKLPKVVIPVHFAGQSCDMEAIGRLAGRYGFTVIEDASHAIGGRYKSEPVGNCRHSAMTVFSFHPVKIITTGEGGMVLTNSAELHERLVRLRSHGITRDPALMAGESHGPWYYEQIELGFNYRMTDIQAALGVSQMTRLDEFVERRHHLAKRYDEALRDDPFVLPFQHPDSYSAFHLYVIRLQAGEPGSGHKGRKEVFEALRQRGILVNVHYIPVHIQPYYRANGFDAGDFPQAEQYYREAITLPLYAGLAEIDQDRVITALQELLCPPSAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YK1</accession>
    <name>Q39YK1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar basal-body rod protein FlgF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flgF</name>
        <name evidence="7" type="ordered locus">Gmet_0430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The basal body constitutes a major portion of the flagellar organelle and consists of five rings (E,L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512402.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0430"/>
    <dbReference type="DNASU" id="3738361"/>
    <dbReference type="EnsemblBacteria" id="ABB30673">
        <property type="protein sequence ID" value="ABB30673"/>
        <property type="gene ID" value="Gmet_0430"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0430"/>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_0_1_7"/>
    <dbReference type="OMA" id="NLYFAIQ"/>
    <dbReference type="OrthoDB" id="947161at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012836">
        <property type="entry name" value="FlgF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02490">
        <property type="entry name" value="flgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="5">
        <location>
            <begin position="5"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="6">
        <location>
            <begin position="166"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="242" mass="25567" checksum="D52819C3A8DCEAF2" modified="2005-11-22" version="1">MNSGIYSALTGNVAAMKRLDVLSNNLANVNTPGFKKDRMTFESMLQTVGAQPRPGGGTDAPVFAETTFFTDYSPGSVKQTGNPFDLAIDGDGFFAVTTADGQRAYTRQGNFRLDSTGRLVTADGAQVAGGVVIAGGKVDINGKGEVLVDGSQVGRLEVVDFPKPYALQKLGGGLFVPADPQATPNPVTGEKVMQGAIEESNVNTVQEMVQLIETNRYFEMCSKVVKAYDDLTGKAANEIGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YR1</accession>
    <name>Q39YR1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512342.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0370"/>
    <dbReference type="EnsemblBacteria" id="ABB30613">
        <property type="protein sequence ID" value="ABB30613"/>
        <property type="gene ID" value="Gmet_0370"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0370"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_7_1_7"/>
    <dbReference type="OMA" id="RYPVRMY"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="75"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="265" mass="29438" checksum="43DF9656DE2CC9A3" modified="2005-11-22" version="1">MQKKDKSDYMILAVSHALDLLEQFHGEGVSELGVTELAKRLRLHKNNVFRLLATLEARGYVEQNRVTGNYRLGLKTLEIRQTMIRQMALLPYAKPVLEELVRECDETAYVSILKENLSIYLYGVESRATVRVVSRLGSRLPAYCTAAGKVMLASLSEPKLERYLARKELVPFTPNTITDATRLREHLKEIAAAGYAIDNEELEIGVRGVAAPIRDYRTETVGAVIISGPTMRFSDERVAAELVPLAQKAAETISVKLGYSGAAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YS1</accession>
    <name>Q39YS1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512332.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0360"/>
    <dbReference type="EnsemblBacteria" id="ABB30603">
        <property type="protein sequence ID" value="ABB30603"/>
        <property type="gene ID" value="Gmet_0360"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0360"/>
    <dbReference type="eggNOG" id="ENOG5032SEX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2167345_0_0_7"/>
    <dbReference type="OrthoDB" id="1899588at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015017">
        <property type="entry name" value="DUF1904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08921">
        <property type="entry name" value="DUF1904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="110" mass="12519" checksum="7E4416B991C7F434" modified="2005-11-22" version="1">MPYLRFKGFDEGFLRKLGPLVVEEFSRVAVVPPEVVKIELLNIVQITATPRSLEIFIFPRDQKKHDAIAATLAGILGRYGYDDVHIFFVLLSPSLYYKEGIPLNNVSWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YT2</accession>
    <name>Q39YT2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cofac_haem_bdg domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512320.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0349"/>
    <dbReference type="DNASU" id="3738913"/>
    <dbReference type="EnsemblBacteria" id="ABB30592">
        <property type="protein sequence ID" value="ABB30592"/>
        <property type="gene ID" value="Gmet_0349"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0349"/>
    <dbReference type="eggNOG" id="COG3016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035488_2_0_7"/>
    <dbReference type="OMA" id="FCEAQTL"/>
    <dbReference type="OrthoDB" id="1240854at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd14727">
        <property type="entry name" value="ChanN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007314">
        <property type="entry name" value="Cofac_haem-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016773">
        <property type="entry name" value="Fe3_uptake_reg_CjrA_prd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04187">
        <property type="entry name" value="Cofac_haem_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020419">
        <property type="entry name" value="Fe_uptake_reg_CjrA_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cofac_haem_bdg" evidence="1">
        <location>
            <begin position="45"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="282" mass="32023" checksum="ED6940FD4B18DDC8" modified="2005-11-22" version="1">MKRFGRFAGIALVLVVAALTARSCFSHDLIVRLSDRKEISFKQMMGDLRKVAVIYVGEVHDNPDHHVLQLRIIRGLHRAGVPLAIGMEMFTAGSQQELDRWVAGQTGTAAFQRIYRREWNLPWSLYGDILLFARDKRIPLIGLNVPRDITRKVGREGFASLTEDERRKLPPNITCDVDESYMAMIHRSYSSHGLSANTFRNFCEAQMLWNKSMAYHMVEYLRKNPGRTVVVITGGGHAIRGGMPVQVDRERPGLSSRVVLPDPVVRNGRIKAEEADYLWLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YX5</accession>
    <name>Q39YX5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Phosphoenolpyruvate carboxylase</fullName>
            <shortName evidence="10">PEPC</shortName>
            <shortName evidence="10">PEPCase</shortName>
            <ecNumber evidence="5 10">4.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ppc</name>
        <name evidence="13" type="ordered locus">Gmet_0304</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>oxaloacetate + phosphate = hydrogencarbonate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:28370"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PEPCase type 1 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.31" evidence="5 10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514016.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0304"/>
    <dbReference type="EnsemblBacteria" id="ABB30549">
        <property type="protein sequence ID" value="ABB30549"/>
        <property type="gene ID" value="Gmet_0304"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0304"/>
    <dbReference type="eggNOG" id="COG2352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006557_2_0_7"/>
    <dbReference type="OMA" id="PWVFGWT"/>
    <dbReference type="OrthoDB" id="398146at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00595">
        <property type="entry name" value="PEPcase_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022805">
        <property type="entry name" value="PEP_COase_bac/pln-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018129">
        <property type="entry name" value="PEP_COase_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PTHR30523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00781">
        <property type="entry name" value="PEPCASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0120">Carbon dioxide fixation</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="10 11">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" evidence="10 12">
        <location>
            <position position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB30549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="931" mass="103902" checksum="F8D5AA0FCC02E2BE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z01</accession>
    <name>Q39Z01_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion system needle sheath protein TssB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tssB</name>
        <name evidence="1" type="ordered locus">Gmet_0278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513595.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0278"/>
    <dbReference type="EnsemblBacteria" id="ABB30523">
        <property type="protein sequence ID" value="ABB30523"/>
        <property type="gene ID" value="Gmet_0278"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0278"/>
    <dbReference type="eggNOG" id="COG3516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111033_1_0_7"/>
    <dbReference type="OMA" id="RINIRYV"/>
    <dbReference type="OrthoDB" id="1278805at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008312">
        <property type="entry name" value="T6SS_TssB1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35850">
        <property type="entry name" value="PTHR35850"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05591">
        <property type="entry name" value="T6SS_VipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028301">
        <property type="entry name" value="UCP028301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03358">
        <property type="entry name" value="VI_chp_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="162" mass="17786" checksum="B7F500F287F35ED3" modified="2005-11-22" version="1">MSKEASVAPKERVNIVYRPASDGAAEEVELPLKMLVMGDFTGTPDERPVEKRDPVAIDKETFNDVMKAQGISLNIAVPNRLAGEAGDELPVNLKVESLKDFGPEAVVEQVPEMKRLLELREALRALKGPLSNVPDFRRKIQELITDDAARAKLLAEIGIEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z42</accession>
    <name>Q39Z42_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock DNA/RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513554.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0237"/>
    <dbReference type="EnsemblBacteria" id="ABB30482">
        <property type="protein sequence ID" value="ABB30482"/>
        <property type="gene ID" value="Gmet_0237"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0237"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_1_7"/>
    <dbReference type="OMA" id="APVREND"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="66" mass="7172" checksum="48A3E326E868F674" modified="2005-11-22" version="1">MVNGTVKWFNDSKGFGFLEQDNGEDVFCHFSAIAGDGFKSLTEGDRVTFEVTKGPKGLQAANVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z64</accession>
    <name>Q39Z64_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512803.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0214"/>
    <dbReference type="EnsemblBacteria" id="ABB30460">
        <property type="protein sequence ID" value="ABB30460"/>
        <property type="gene ID" value="Gmet_0214"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0214"/>
    <dbReference type="eggNOG" id="ENOG5032Y3P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166635_0_0_7"/>
    <dbReference type="OrthoDB" id="1694349at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045397">
        <property type="entry name" value="DUF6516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20126">
        <property type="entry name" value="DUF6516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="95" mass="10921" checksum="77F935B959F4C4F1" modified="2005-11-22" version="1">MGAVLVFRDKKVKEGLIIELVVWELDAPLSGSSHPFKYRLFCGSLETGTCLVRYDNERGKGDHRHVADEEQPYQFTSLEVLFADFEKDVREAMKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z95</accession>
    <name>Q39Z95_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiol peroxidase</fullName>
            <shortName evidence="2">Tpx</shortName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peroxiredoxin tpx</fullName>
            <shortName evidence="2">Prx</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tpx</name>
        <name evidence="4" type="synonym">prx-3</name>
        <name evidence="4" type="ordered locus">Gmet_0183</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[thioredoxin]-dithiol + a hydroperoxide = [thioredoxin]-disulfide + an alcohol + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. Tpx subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512772.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0183"/>
    <dbReference type="EnsemblBacteria" id="ABB30429">
        <property type="protein sequence ID" value="ABB30429"/>
        <property type="gene ID" value="Gmet_0183"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0183"/>
    <dbReference type="eggNOG" id="COG2077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_12_0_7"/>
    <dbReference type="OMA" id="ITQEPNY"/>
    <dbReference type="OrthoDB" id="1738458at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03014">
        <property type="entry name" value="PRX_Atyp2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00269">
        <property type="entry name" value="Tpx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002065">
        <property type="entry name" value="TPX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018219">
        <property type="entry name" value="Tpx_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01265">
        <property type="entry name" value="TPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="22"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="171" mass="18395" checksum="B972CD422CCAA53B" modified="2005-11-22" version="1">MQERPGIITFKGNPMTLLGPALAVGDKAPAFIAVDTGLAPVSLADFAGKVKIISAVPSLDTPVCDTETRRFNQEAATLPDNVVLLTVSMDLPFAQKRWCGAAGIDRVKTLSDYRDRSFGLAYGVVIKELMLLSRSLFVIDATDTIRYLQHVPEVTSEPDYAAVLAAAKSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z99</accession>
    <name>Q39Z99_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-uridine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0179</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EC" id="2.5.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512766.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0179"/>
    <dbReference type="DNASU" id="3739063"/>
    <dbReference type="EnsemblBacteria" id="ABB30425">
        <property type="protein sequence ID" value="ABB30425"/>
        <property type="gene ID" value="Gmet_0179"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0179"/>
    <dbReference type="eggNOG" id="COG3148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066458_2_3_7"/>
    <dbReference type="OMA" id="WQPYVVF"/>
    <dbReference type="OrthoDB" id="1719529at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039262">
        <property type="entry name" value="DTWD2/YfiP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392">
        <property type="entry name" value="PTHR21392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="5">
        <location>
            <begin position="7"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="199" mass="22405" checksum="31B11C27DB42BD9E" modified="2005-11-22" version="1">MGTRSKRSERCGRCRMHLERCVCPAIPRYDLTTRVVLVMHHREYPKPTATGPLALAALPNSELRIHGERDSLLDLGDLATPERRTLLLYPGDDVPVLTRELLERDRRPVTLVVPDGTWRQASRMGRRLPGLDHAEMVRLPEGLPTEWGIRRENHPQGLATFEAIARALGIIESPAVQTGLEELFRLMVRRTLSAGGRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZE9</accession>
    <name>Q39ZE9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514131.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0126"/>
    <dbReference type="EnsemblBacteria" id="ABB30375">
        <property type="protein sequence ID" value="ABB30375"/>
        <property type="gene ID" value="Gmet_0126"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0126"/>
    <dbReference type="eggNOG" id="COG5626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137225_1_0_7"/>
    <dbReference type="OMA" id="WEWLIPH"/>
    <dbReference type="OrthoDB" id="1845842at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018741">
        <property type="entry name" value="DUF2288"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10052">
        <property type="entry name" value="DUF2288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="95" mass="10539" checksum="C43F24F0497F3A0C" modified="2005-11-22" version="1">MKPTKEELALQVDVAEWNWLRAHLERGGLIVVAPELEIAEVGERIARDDTATVGAWIETGKLSKPSEGQIAAWDADKAARFSTLIISPYVLMKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEN6</accession>
    <name>J9JEN6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3612"/>
    <dbReference type="EnsemblBacteria" id="AFR42831">
        <property type="protein sequence ID" value="AFR42831"/>
        <property type="gene ID" value="Gmet_3612"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3612"/>
    <dbReference type="HOGENOM" id="CLU_2861370_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="64" mass="7541" checksum="D4D1F3B899FBE504" modified="2012-10-31" version="1">MRHMGKMGLLCRWRSDRVIYELKACSAGAEYAVDTTHEHGSTGQDVDRQYMMWHSLVLFFELQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEP2</accession>
    <name>J9JEP2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3630"/>
    <dbReference type="EnsemblBacteria" id="AFR42846">
        <property type="protein sequence ID" value="AFR42846"/>
        <property type="gene ID" value="Gmet_3630"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3630"/>
    <dbReference type="HOGENOM" id="CLU_2953945_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="59" mass="6872" checksum="081C2511ABA9BC96" modified="2012-10-31" version="1">MLKPYRQSLYHCKKTGTNKQRLSIYVPEDTMQKLENWIAKNESKMTPGQAITDILSMVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2000-05-30" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>P81894</accession>
    <accession>Q39RK4</accession>
    <name>CYC7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName>Cytochrome c7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_2902</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="1999" name="FEMS Microbiol. Lett." volume="175" first="205" last="210">
            <title>Purification and characterization of triheme cytochrome c7 from the metal-reducing bacterium, Geobacter metallireducens.</title>
            <authorList>
                <person name="Afkar E."/>
                <person name="Fukumori Y."/>
            </authorList>
            <dbReference type="PubMed" id="10386369"/>
            <dbReference type="DOI" id="10.1111/j.1574-6968.1999.tb13621.x"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 21-37</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2000" name="Anaerobe" volume="6" first="187" last="196">
            <title>Electron transfer in the dissimilatory iron-reducing bacterium Geobacter metallireducens.</title>
            <authorList>
                <person name="Champine J.E."/>
                <person name="Underhill B."/>
                <person name="Johnston J.M."/>
                <person name="Lilly W.W."/>
                <person name="Goodwin S."/>
            </authorList>
            <dbReference type="DOI" id="10.1006/anae.2000.0333"/>
        </citation>
        <scope>PROTEIN SEQUENCE OF 21-57</scope>
        <scope>FUNCTION</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>MASS SPECTROMETRY</scope>
    </reference>
    <comment type="function">
        <text evidence="2 3">May be involved in anaerobic iron respiration.</text>
    </comment>
    <comment type="biophysicochemical properties">
        <redoxPotential>
            <text evidence="2 3">E(0) is -91 mV (Ref.3) or -190 mV.</text>
        </redoxPotential>
    </comment>
    <comment type="PTM">
        <text>Binds 3 heme groups per subunit.</text>
    </comment>
    <comment type="mass spectrometry" mass="9684.0" error="10.0" method="MALDI" evidence="3"/>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome c family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512838.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="P81894"/>
    <dbReference type="SMR" id="P81894"/>
    <dbReference type="STRING" id="269799.Gmet_2902"/>
    <dbReference type="EnsemblBacteria" id="ABB33120">
        <property type="protein sequence ID" value="ABB33120"/>
        <property type="gene ID" value="Gmet_2902"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2902"/>
    <dbReference type="eggNOG" id="ENOG50335B9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188310_0_0_7"/>
    <dbReference type="OMA" id="HSAKNEC"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009061">
        <property type="term" value="P:anaerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002322">
        <property type="entry name" value="Cyt_c_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020942">
        <property type="entry name" value="Cyt_c_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02085">
        <property type="entry name" value="Cytochrom_CIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00609">
        <property type="entry name" value="CYTOCHROMEC3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0903">Direct protein sequencing</keyword>
    <keyword id="KW-0249">Electron transport</keyword>
    <keyword id="KW-0349">Heme</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0763">Sulfate respiration</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="2 3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000108368" description="Cytochrome c7">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="1">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>3</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="sequence conflict" description="In Ref. 3; AA sequence." evidence="4" ref="3">
        <original>DE</original>
        <variation>RR</variation>
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 2; AA sequence." evidence="4" ref="2">
        <original>H</original>
        <variation>P</variation>
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 3; AA sequence." evidence="4" ref="3">
        <original>C</original>
        <variation>K</variation>
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="sequence conflict" description="In Ref. 3; AA sequence." evidence="4" ref="3">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="10386369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source ref="3"/>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <sequence length="90" mass="9898" checksum="E313736D14B27DFF" modified="2006-03-07" version="2" precursor="true">MKRIIASLALSVFCAGLAFAADELTFKAKNGDVKFPHKKHQQVVGNCKKCHEKGPGKIEGFGKDWAHKTCKGCHEEMKKGPTKCGDCHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PT4</accession>
    <name>Q39PT4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Heme chaperone HemW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">hemN</name>
        <name evidence="12" type="ordered locus">Gmet_3535</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513691.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3535"/>
    <dbReference type="EnsemblBacteria" id="ABB33740">
        <property type="protein sequence ID" value="ABB33740"/>
        <property type="gene ID" value="Gmet_3535"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3535"/>
    <dbReference type="eggNOG" id="COG0635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027579_1_1_7"/>
    <dbReference type="OMA" id="HIPWCVR"/>
    <dbReference type="OrthoDB" id="1130951at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004109">
        <property type="term" value="F:coproporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034505">
        <property type="entry name" value="Coproporphyrinogen-III_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010723">
        <property type="entry name" value="HemN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004559">
        <property type="entry name" value="HemW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13932">
        <property type="entry name" value="PTHR13932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06969">
        <property type="entry name" value="HemN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00562">
        <property type="entry name" value="HemN-like__clustered_with_heat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00539">
        <property type="entry name" value="hemN_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0349">Heme</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="383" mass="42059" checksum="74023257BC1E49F8" modified="2005-11-22" version="1">MDDTTALYIHIPFCVRKCLYCAFASTDEAPLAIGEYTALLLREMELRAAALASPLRATTLYLGGGTPSLLEPDLVGNIIDGAARLFWLDPSAEITLEANPGTVTADSLAGYRGAGVNRLSLGVQSFDDRMLERLGRVHTAREAKDAFALARRAGFDNIGIDLIHGLPDQSLDHWRDQLRMAAALRPGHISAYGLTVEEGTPFARLEDQGVLALPDEDDAAAMFEETAEVLAAAGYEQYEIANFALPGRRSRHNQVYWRRWNYLGFGAGAHSFLREPFPGIRWRNPDDLGTYGCSLADGVLPETDIALLAEEDAMAEWLFLGLRMLEGIEEARFREEFGRPLMEIHGTAIEGFCAAGLLVRGGGRLRLTRRGVILSNRVFAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PU4</accession>
    <name>Q39PU4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33730.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3525"/>
    <dbReference type="EnsemblBacteria" id="ABB33730">
        <property type="protein sequence ID" value="ABB33730"/>
        <property type="gene ID" value="Gmet_3525"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3525"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037716_0_0_7"/>
    <dbReference type="OMA" id="HCADGFG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33730.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="367" mass="41152" checksum="AD8F3ABE5E92E38B" modified="2012-10-31" version="2">MKSHIPYMRRRVVAVAACGVLFLLSVLPGCKFNKAQQESSRSVETLESTAIAGKKTVAPPPQPEEPRFKPVSSSRVATPKNRYRTGENPEVAAQAGWPVKSPNPLPGAILPGRRIVAYYGNPLSKKMGALGEHPKDDMLRRLKEEVSRWEKADPSKPVQPALHLIAVVAQGDPGKSGKYRMVMPDDVVNQVHEWAREANALMFIDIQTGHENIRTLLPRFEWLLKNPDVHLGIDPEFNLVKSGAKPGTKIGTYDAADINYVTEYLSRLVKTNNLPPKVLTVHRFTRNGVTNARKITLRPEVQIVMHMDGWGAPSLKRDSYADYIVAEPVQYTGFKLFYHNDTKKGDPMMTPREVLMLDPKPLYVQYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PY8</accession>
    <name>Q39PY8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ordered locus">Gmet_3478</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366197.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3478"/>
    <dbReference type="EnsemblBacteria" id="ABB33686">
        <property type="protein sequence ID" value="ABB33686"/>
        <property type="gene ID" value="Gmet_3478"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3478"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_21_7"/>
    <dbReference type="OMA" id="HESACEV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="16">
        <location>
            <begin position="298"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="14">
        <location>
            <begin position="363"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="15">
        <location>
            <begin position="429"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="776"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="737"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB33686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113721" checksum="CE6F858DFAFF8D3E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q26</accession>
    <name>Q39Q26_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514664.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3436"/>
    <dbReference type="EnsemblBacteria" id="ABB33648">
        <property type="protein sequence ID" value="ABB33648"/>
        <property type="gene ID" value="Gmet_3436"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3436"/>
    <dbReference type="eggNOG" id="ENOG5032ZSF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2450419_0_0_7"/>
    <dbReference type="OMA" id="QHFNTRV"/>
    <dbReference type="OrthoDB" id="1945941at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="87" mass="9930" checksum="3C31997E7D6C855E" modified="2005-11-22" version="1">MSLIDNPDQAKRLARAIISDIAIYNREKVERGIKEDSIFELLAEEIEEGRQHFQSRVAPELSSEAIYDMALVDVLIKRAGKIESSIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q30</accession>
    <name>Q39Q30_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_3432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3432"/>
    <dbReference type="EnsemblBacteria" id="ABB33644">
        <property type="protein sequence ID" value="ABB33644"/>
        <property type="gene ID" value="Gmet_3432"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3432"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016375_0_0_7"/>
    <dbReference type="OMA" id="YFFSGCF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="583"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="538"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="796" mass="88651" checksum="3EB70428D12A4F0F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q32</accession>
    <name>Q39Q32_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heterodisulfide oxidoreductase, iron-sulfur cluster-binding subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hdrE</name>
        <name evidence="5" type="ordered locus">Gmet_3430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514658.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3430"/>
    <dbReference type="EnsemblBacteria" id="ABB33642">
        <property type="protein sequence ID" value="ABB33642"/>
        <property type="gene ID" value="Gmet_3430"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3430"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046702_0_0_7"/>
    <dbReference type="OMA" id="THKLGTW"/>
    <dbReference type="OrthoDB" id="1092632at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17179">
        <property type="entry name" value="Fer4_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="295"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="342" mass="37307" checksum="A76F11D70329E209" modified="2005-11-22" version="1">MPKTISEQNLLRLIDTLVNEGKRVIGPKAAGTMTLYEPLATGEELNLGELPRRSAKETFFPLCETILTYERDREGVRVTDVDPGAIPETVLVAARPCDVAAAPVLDSVFSWDYQDEFYLSRRGKTTIIGLACARADDACFCTAVGLSTNDTKGSDLFLTTLTGGGYRCDVITDKGMALLAAHGGLFAEGDGTPAPLAEPALGKLDLEKIKQWLDNHFEDPLWEEIAERCAGCGACAFLCPACHCFDINDEGGEKKGARRKSWDACGFGKFTNHASGHNPRDVQPQRYRNRIMHKFKYYVDKFDQRLCTGCGRCIRACPVGIDIAEILSAIGTRDQGPGTGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q43</accession>
    <name>Q39Q43_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Pyruvate:ferredoxin/flavodoxin oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">por</name>
        <name evidence="14" type="ordered locus">Gmet_3419</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 3 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514226.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3419"/>
    <dbReference type="EnsemblBacteria" id="ABB33631">
        <property type="protein sequence ID" value="ABB33631"/>
        <property type="gene ID" value="Gmet_3419"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3419"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002569_0_0_7"/>
    <dbReference type="OMA" id="NTVMQVC"/>
    <dbReference type="OrthoDB" id="10483at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000159">
        <property type="entry name" value="NifJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="687"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="743"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="983"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="region of interest" description="Thiamine pyrophosphate binding" evidence="10">
        <location>
            <begin position="1012"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="696"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="699"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="706"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="752"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="755"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="758"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="762"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="826"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="829"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="831"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 12">
        <location>
            <position position="854"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1091"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="11">
        <location>
            <position position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000159-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB33631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1195" mass="129193" checksum="D93B4D4EB2650514" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q99</accession>
    <name>Q39Q99_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type II secretion system protein GspC, putative serine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gspC</name>
        <name evidence="7" type="ordered locus">Gmet_3363</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512589.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3363"/>
    <dbReference type="EnsemblBacteria" id="ABB33575">
        <property type="protein sequence ID" value="ABB33575"/>
        <property type="gene ID" value="Gmet_3363"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3363"/>
    <dbReference type="eggNOG" id="COG3031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_955656_0_0_7"/>
    <dbReference type="OMA" id="LKGQSRI"/>
    <dbReference type="OrthoDB" id="1597080at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024961">
        <property type="entry name" value="T2SS_GspC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11356">
        <property type="entry name" value="T2SSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="PDZ" evidence="6">
        <location>
            <begin position="209"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="290" mass="30844" checksum="C89AE9318D5AA18B" modified="2005-11-22" version="1">MKKIYFITALLLILNSLALARIAAALVGYRLSHTLQSTVNRTHNAVKPAQSEALSAYAPIVEKGLFGRAAQGKLTLLTATAPVAKGSNPPSAQGDLVLVGTVRGSFRETFALIRRTTPPEERVFRLGDQVFERGPLVSVQKESVEILSGGKRVKLLTPQATPSESPASPSPQGPAVTGGATQTGSGTFVVDQRLLNAALDNIGQAMTDARLLPSVKDGKVEGFRVSEVKPSGVFAMVGIKNGDVLHKINDLPVDSPERAIQSLASLKGQNRIKLDLVRDGQPSTFSYDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QA0</accession>
    <name>Q39QA0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="6">3.4.21.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">degP-1</name>
        <name evidence="8" type="ordered locus">Gmet_3362</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.</text>
            <dbReference type="EC" id="3.4.21.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366183.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3362"/>
    <dbReference type="MEROPS" id="S01.453"/>
    <dbReference type="EnsemblBacteria" id="ABB33574">
        <property type="protein sequence ID" value="ABB33574"/>
        <property type="gene ID" value="Gmet_3362"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3362"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_0_7"/>
    <dbReference type="OMA" id="GPLFNQR"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="250"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="378"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="464" mass="49933" checksum="0FA09AC141A98C65" modified="2005-11-22" version="1">MKLSSLRFFKEIVFAACLAVLAVGESPAKVLTPDFVDLAEKLKPTVVNISTTKTLTPQFRMRRQPSPFPDPFQDFFEHFFEEMPRRPQRERSLGSGFIISKQGFIITNNHVIAGADEIKVRLSDGREFKAEVKGSDEKLDLALIKIDAKENLPVAELGDSAQIKVGEWVMAIGNPFGLAQTVTAGIVSATGRVIGSGPYDDFIQTDASINPGNSGGPLFNAEGKVIGINTAIVAGGQGIGFAIPVNMAKDVLPQLEEKGKVTRGWLGVTMQPMSPELAKSFGLEGEKGALITDVVKDGPAANAGLRSGDIILEFDGKKINEMSELPRLVAAEPIGKAVKIKVLREGKPREFTVSVGRLAESGDENNQKTAGDAFGLSARELTKDLAARLGLKESRGVVVTGVKQGSIAELGGFQSGDIILEIGDKAVATVMDYEKLIKEYGKGDVVRFLLRRGDSNYYLALRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QC1</accession>
    <name>Q39QC1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366180.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3340"/>
    <dbReference type="EnsemblBacteria" id="ABB33553">
        <property type="protein sequence ID" value="ABB33553"/>
        <property type="gene ID" value="Gmet_3340"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3340"/>
    <dbReference type="eggNOG" id="COG1852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067052_0_0_7"/>
    <dbReference type="OMA" id="CPAKLTP"/>
    <dbReference type="OrthoDB" id="1699196at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002829">
        <property type="entry name" value="DUF116"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43801">
        <property type="entry name" value="PTHR43801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01976">
        <property type="entry name" value="DUF116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="251" mass="27531" checksum="F0C00A862327D3FF" modified="2005-11-22" version="1">MPDNTPKKRLFIVLMGVTCLLIVGAIYLLWWIPTTGLANIHPSLPRIAGIVFGGLSLLALLGTLVLVLTSALGKDILFTRFLRGVVIKFLLPAIELIGRTFGISIDTIRQSFIAMNNSLVLSQRRRVKPDRVLILLPHCLQLFECEIKVTGNINKCVRCGRCDIMGLAELAEKYSIDISVATGGTLARKVIIEKRPKLVLAVACERDLTSGIKDCYPLPVIGVLNDRPFGPCFNTKVDIEKINEALQAVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QF8</accession>
    <name>Q39QF8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3303</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512527.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3303"/>
    <dbReference type="EnsemblBacteria" id="ABB33516">
        <property type="protein sequence ID" value="ABB33516"/>
        <property type="gene ID" value="Gmet_3303"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3303"/>
    <dbReference type="eggNOG" id="ENOG50338CY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651747_0_0_7"/>
    <dbReference type="OMA" id="QYVSTRY"/>
    <dbReference type="OrthoDB" id="837523at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223262" evidence="1">
        <location>
            <begin position="22"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="448" mass="47768" checksum="B8B2C81AC57690AC" modified="2005-11-22" version="1">MRFTLMYCAAALVMLAVPVSAQDVPQQSPPAYNCDFEPACEVSPGIYGNMASPVTSKFKLSIGGFVKLDYVYNSVNLGSANGIGLVATLQPNGIPKTSSPAAKQDQSLFSARQSRIWFKAEGPTFLGARTGALIETDFFGSGGSSNETATMRIRLAYGTLDWANTQILFGQSWDLFGPAAASTVDFGQGQTAGNPTTPRVPQLRVSQKVRLSEQNSLKLIAALQNPIQNSNTANGTAGESWGARPNIAGQAMLVSKALGAAPGFWGLPMNQFTVGLFGLYGNQEIAGNGGTVDSWGYGLYAFVPVLRSADGKSRAMTASFEGQAYRAANMSFNYATVSPLIGPQGDKTGAKGYGLFGQMIFYPTQNLGITAGYGMRGAENFADYTRSGIKDFQKSNSQAFANIAYDLNAAVRVATEYQYVSTRYGNVTAGTSDFGKANVFRFSMIYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QG3</accession>
    <name>Q39QG3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512522.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3298"/>
    <dbReference type="EnsemblBacteria" id="ABB33511">
        <property type="protein sequence ID" value="ABB33511"/>
        <property type="gene ID" value="Gmet_3298"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3298"/>
    <dbReference type="HOGENOM" id="CLU_1523042_0_0_7"/>
    <dbReference type="OMA" id="APATIWV"/>
    <dbReference type="OrthoDB" id="2056410at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223157" evidence="1">
        <location>
            <begin position="22"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="176" mass="18483" checksum="D7FC1E2E0379166E" modified="2005-11-22" version="1">MKACPLAVILVLLLLAGCAGSRPVPAPTEEYVEVDNPAATMSPSAPATIWVPKRYVDNGIPRGGELVKKGYEAATRGSGEISSPPARAEESRSYARYNRVVSVEKERVCFNTDRNAGIKPGVKLRLYRGGSVVEGIGFVPGNVVGTVTITDPVGSGACGTLDQGGEARVNDLVRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QG6</accession>
    <name>Q39QG6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512519.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3295"/>
    <dbReference type="EnsemblBacteria" id="ABB33508">
        <property type="protein sequence ID" value="ABB33508"/>
        <property type="gene ID" value="Gmet_3295"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3295"/>
    <dbReference type="eggNOG" id="ENOG502ZA7Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116203_0_0_7"/>
    <dbReference type="OMA" id="DYPCKSA"/>
    <dbReference type="OrthoDB" id="1897347at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="192" mass="21822" checksum="31F8DF14A7D4A3A4" modified="2005-11-22" version="1">MSDTCCAPGFMPPKSIILDEGVRLLYDLNKDQLVDIIVDSAKNWLAHDGLWFQAIEATHGMDAAMDADREAWRKFTVIEAQRIMARLGIEPGGGIPALVECLKHRLYARLNLQQMDEATDTRAVFMMVDCRVQSARKRKGLPDFPCKSVGIVEYAEFARTVDPRIETRCIACPPDPHPDYFWCAWEFTLRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QJ8</accession>
    <name>Q39QJ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Flagellar biogenesis master sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fgrM</name>
        <name evidence="8" type="ordered locus">Gmet_3263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366169.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3263"/>
    <dbReference type="EnsemblBacteria" id="ABB33476">
        <property type="protein sequence ID" value="ABB33476"/>
        <property type="gene ID" value="Gmet_3263"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3263"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="LNYPQLT"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="144"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="464" mass="52212" checksum="DCE78335ABE6C0C4" modified="2005-11-22" version="1">MDTPRLLIADDDKKTRDFVAAFLKYKGYDVVQACDGQDALDKLETEEVHLVITDLMMPRVNGLEFVKKLKTMRPGTVIIAYSAFGNYEMASNLLKAGVFFYLEKPFNLDELETHVKRGFEHQSLQSQTYRAKPALKNRALMPNIIGESSKMLSLFELIEKVAESDSTVLIQGESGTGKELVARAVHDLSNRKTRNFVPVNCAAIPDELLESELFGHVKGSFTGAVANRIGRFEMADRGTLFLDEIGDMKPNLQVKLLRVLQNRELEPVGATRSKKIDVRIIAATNQNLEKLVATKQFREDLYYRLSVIPIFIPPLRERKEDIPLLVNSFLERFNRNKKSKVKGIDSDAMDLLVHYDWPGNVRELENLVERLVILKGFGAIGVNDLPEKFSGVTISPPSESMTLPDSGICLNTVVEEFENNLILQALKKTGGNKKEAALLLNLKRTTLIEKLKKRRLDTIATSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QQ0</accession>
    <name>Q39QQ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver CheY associated with MCPs of class 44H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY44H</name>
        <name evidence="3" type="ordered locus">Gmet_3211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512649.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3211"/>
    <dbReference type="EnsemblBacteria" id="ABB33424">
        <property type="protein sequence ID" value="ABB33424"/>
        <property type="gene ID" value="Gmet_3211"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3211"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_15_7"/>
    <dbReference type="OMA" id="LFMRKML"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="122" mass="13468" checksum="07EA6219201675E8" modified="2005-11-22" version="1">MAKKRVMVVDDALFMRNMLRGILEANGFEVVAEAADGAEAVVTYRDVRPDIVTLDIIMPVKNGIEALREIMAIDPHARVVICSAVGQESLVQKAQSFGARDFILKPFNPDRVKEIIKKVSEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-10-13" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QR4</accession>
    <name>OBG_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Obg</fullName>
            <ecNumber evidence="1">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein Obg</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">obg</name>
        <name type="ordered locus">Gmet_3197</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512635.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QR4"/>
    <dbReference type="SMR" id="Q39QR4"/>
    <dbReference type="STRING" id="269799.Gmet_3197"/>
    <dbReference type="EnsemblBacteria" id="ABB33410">
        <property type="protein sequence ID" value="ABB33410"/>
        <property type="gene ID" value="Gmet_3197"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3197"/>
    <dbReference type="eggNOG" id="COG0536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011747_2_3_7"/>
    <dbReference type="OMA" id="VVFDWEP"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01898">
        <property type="entry name" value="Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01454">
        <property type="entry name" value="GTPase_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014100">
        <property type="entry name" value="GTP-bd_Obg/CgtA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="PTHR11702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002401">
        <property type="entry name" value="GTP_bd_Obg/CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="SSF82051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02729">
        <property type="entry name" value="Obg_CgtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000385952" description="GTPase Obg">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Obg" evidence="2">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="1">
        <location>
            <begin position="160"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="166"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="191"/>
            <end position="195"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="213"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="283"/>
            <end position="286"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="312"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="338" mass="36890" checksum="CB69FB3618B9A9DF" modified="2005-11-22" version="1">MQFIDEVKIHVQSGHGGAGCVSFRREKFIPFGGPDGGDGGKGGDVIFTVDPNLSTLMDLRYRPHLKAGRGKNGMGKDRHGANGDDLTIPVPPGTIVKDAETGEILADLTEPGQTVVLLKGGRGGQGNARFTTSTNRAPKFAQPGEDEEERWLRLELKLMADVGLLGFPNVGKSSFITKVSAARPKIADYPFTTIKPNLGVVSYKNYRSFVVADIPGIIEGASEGAGLGHRFLKHVERTNILLHLIDLSWIPDRDPIREYETLNRELALFSPELAGKEQIAVINKIDLPVVRENLPSVIDWFKERGIAVFPISAATGEGIPTLLDEIARHLWGQAEEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QU1</accession>
    <name>Q39QU1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">frx-6</name>
        <name evidence="8" type="ordered locus">Gmet_3170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513886.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3170"/>
    <dbReference type="EnsemblBacteria" id="ABB33383">
        <property type="protein sequence ID" value="ABB33383"/>
        <property type="gene ID" value="Gmet_3170"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3170"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_4_7"/>
    <dbReference type="OMA" id="ASGRSEC"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="63" mass="6834" checksum="111231A775D9DA6F" modified="2005-11-22" version="1">MARRPWVDQEACISCGLCVSVCPGVFRFAENGKSEAYDPAGASEQEIQQAIDGCPVQAISWKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QY3</accession>
    <name>Q39QY3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux pump, RND family, inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514302.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3127"/>
    <dbReference type="EnsemblBacteria" id="ABB33341">
        <property type="protein sequence ID" value="ABB33341"/>
        <property type="gene ID" value="Gmet_3127"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3127"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_7"/>
    <dbReference type="OMA" id="LMGPYMR"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="545"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="907"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1071" mass="117641" checksum="0AA0C0EA3C989AE5" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R20</accession>
    <name>Q39R20_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514544.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3090"/>
    <dbReference type="EnsemblBacteria" id="ABB33304">
        <property type="protein sequence ID" value="ABB33304"/>
        <property type="gene ID" value="Gmet_3090"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3090"/>
    <dbReference type="eggNOG" id="ENOG502Z9YV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032899_0_0_7"/>
    <dbReference type="OMA" id="CYGRGFE"/>
    <dbReference type="OrthoDB" id="547682at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021803">
        <property type="entry name" value="DUF3373"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11853">
        <property type="entry name" value="DUF3373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223162" evidence="2">
        <location>
            <begin position="26"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="538" mass="59140" checksum="60D5D5ABDA869D83" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R81</accession>
    <name>Q39R81_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Universal stress protein Usp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">usp-1</name>
        <name evidence="3" type="ordered locus">Gmet_3028</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514342.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3028"/>
    <dbReference type="EnsemblBacteria" id="ABB33243">
        <property type="protein sequence ID" value="ABB33243"/>
        <property type="gene ID" value="Gmet_3028"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3028"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_1_7"/>
    <dbReference type="OMA" id="HEIVKFA"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="2">
        <location>
            <begin position="6"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="151" mass="16807" checksum="AECC39BA32E9B4FA" modified="2005-11-22" version="1">MLNLRKKILVAIDGSPFSDKAAEEAVRMAAGNPSQFKSKIYAMLVLPNAPRSTFTDFVPPPPITETKEWDELRERVFYVIEKNAREADIPLEIKVVYGDPADELIDFAEKEQIDVIVIGSSGKGFLKRKLLGSVSHKVVKNSPCSVYIVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RD8</accession>
    <name>Q39RD8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Radical SAM domain iron-sulfur cluster-binding oxidoreductase with cobalamin-binding-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512904.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2971"/>
    <dbReference type="EnsemblBacteria" id="ABB33186">
        <property type="protein sequence ID" value="ABB33186"/>
        <property type="gene ID" value="Gmet_2971"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2971"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_5_0_7"/>
    <dbReference type="OMA" id="IVIWRQG"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025274">
        <property type="entry name" value="DUF4070"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034530">
        <property type="entry name" value="HpnP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13282">
        <property type="entry name" value="DUF4070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00303">
        <property type="entry name" value="hopanoid_C2-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="159"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="504" mass="56949" checksum="9535273ECA3EB28C" modified="2005-11-22" version="1">MNVLLVYPRYPDSFWSFSHALKFVGKKAAFPPLGLLTVAALFPDSWETRLMDQNVREVTDSDLAWADMVFVSAMIIQRDAVRDLFARCRTLGVTTVAGGPLFTTAPEEFPEADHLVLGEAELTFPPFLEDLAAGHAQRSYTASGRADLTRTPLPRWELLDIGDYAAMNIQYSRGCPFDCEFCDITQLFGRRPRTKSREQLVAELDSLHIRGWKGGVFFVDDNFIGDRNKLKRELLPTIIAWQEAHGRPFSFFTESSIDLADDPQLMALMVEAGFTEVFVGIETPHEEGLDESGKVQNRNRDLLESVKRLQRAGLQVQGGFIVGFDSDPASIFEKQIRFIQESGIVTAMVGMLTALRGTKLHQRLADEGRLLRDASGNNTAIALNFVPRMPTDDLIRGYRQILKGIYSPRPYYRRIITFLKEYRTPPGGFQPNPAHLRAFFSSILFLGVLGRERFQFWKLFAWSLVRRPRLFPLAITLAIFGFHFRKVAEGISATGMFEGKECAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RN4</accession>
    <name>Q39RN4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Fifty-four homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ffh</name>
        <name evidence="9" type="ordered locus">Gmet_2872</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">The SRP-RNC complex is targeted to the cytoplasmic membrane.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514603.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2872"/>
    <dbReference type="EnsemblBacteria" id="ABB33090">
        <property type="protein sequence ID" value="ABB33090"/>
        <property type="gene ID" value="Gmet_2872"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2872"/>
    <dbReference type="eggNOG" id="COG0541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_6_0_7"/>
    <dbReference type="OMA" id="DTAGRHK"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048500">
        <property type="term" value="C:signal recognition particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004780">
        <property type="entry name" value="SRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="PTHR11564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF7">
        <property type="entry name" value="PTHR11564:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="SSF47446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00959">
        <property type="entry name" value="ffh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54" evidence="8">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="190"/>
            <end position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="248"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="452" mass="49920" checksum="0752A3A83B27261E" modified="2005-11-22" version="1">MFENLSDKLDLLFKKLRGQGVMTEENIKEALREVRLVLLEADVNFKVVKDFVEKVRERAVGTQVLQSLSPGQQVIKIVQEELVALMGGGEDNSLDLAAKPPVALMMVGLQGSGKTTTCGKLARLLKGQRRRPLLVPADVYRPAAIEQLRTLGRQLSVETFDSRADQDPVDICREALRYATLNGFDTVILDTAGRLQIDEYLMNELVRIKEAVQPREILFVADAMTGQEAVNVATGFNERLDITGVVLTKLDGDAKGGAALSIRAVTGKPVKLVGLGEKLDALEVFYPDRLVSRILGMGDILTLVEKAQATFDATETERLQQKLKKSQFDLEDFRSQLQQIKKMGSLESILGMIPGVGKAMKQMQGAQPSEKELKRIEAIIDSMTPGERANHQIINGSRRLRIAKGSGTTVQEVNQLLKRFTEAQKVMKQLQKMGPKGLMRGMKGMGKGMFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RY4</accession>
    <name>Q39RY4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Copper-translocating P-type ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">copA</name>
        <name evidence="12" type="ordered locus">Gmet_2772</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511689.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2772"/>
    <dbReference type="EnsemblBacteria" id="ABB32990">
        <property type="protein sequence ID" value="ABB32990"/>
        <property type="gene ID" value="Gmet_2772"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2772"/>
    <dbReference type="eggNOG" id="COG2217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001771_0_3_7"/>
    <dbReference type="OMA" id="NAPLMHL"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00003">
        <property type="entry name" value="TIGR00003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="771"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="3"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="11">
        <location>
            <begin position="75"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="798" mass="84185" checksum="4177C325FF9E8A55" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S25</accession>
    <name>Q39S25_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein ChrA, subunit 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2731</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511729.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2731"/>
    <dbReference type="EnsemblBacteria" id="ABB32949">
        <property type="protein sequence ID" value="ABB32949"/>
        <property type="gene ID" value="Gmet_2731"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2731"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_1_2_7"/>
    <dbReference type="OMA" id="MYAISQA"/>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="174" mass="18702" checksum="6C55A9B8FD5B4942" modified="2005-11-22" version="1">MGSLATIAWTFLKIGLVFVGGGYVLIPLLHRIMVDQYHWLTMKEFLDGLALSQLTPGPLAILATFVGYRAGGFAGALVGTVAIFLPCTALMVFLTRRYERLRNIRLIREVLDGVVPAVVGLVASAGWKLGSTSLGSARDILLFVAGFAILQFTKVSPLFVILGAGALGYFLHFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S70</accession>
    <name>NDK_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoside diphosphate kinase</fullName>
            <shortName evidence="1">NDK</shortName>
            <shortName evidence="1">NDP kinase</shortName>
            <ecNumber evidence="1">2.7.4.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Nucleoside-2-P kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ndk</name>
        <name type="ordered locus">Gmet_2686</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:18113"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NDK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511774.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39S70"/>
    <dbReference type="SMR" id="Q39S70"/>
    <dbReference type="STRING" id="269799.Gmet_2686"/>
    <dbReference type="EnsemblBacteria" id="ABB32904">
        <property type="protein sequence ID" value="ABB32904"/>
        <property type="gene ID" value="Gmet_2686"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2686"/>
    <dbReference type="eggNOG" id="COG0105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060216_8_1_7"/>
    <dbReference type="OMA" id="KIVAMKM"/>
    <dbReference type="OrthoDB" id="1752581at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006165">
        <property type="term" value="P:nucleoside diphosphate phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="SSF54919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDP_KINASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0546">Nucleotide metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000226562" description="Nucleoside diphosphate kinase">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00451"/>
        </source>
    </evidence>
    <sequence length="137" mass="15332" checksum="E39C038B58BD66CC" modified="2005-11-22" version="1">MERTFAIIKPDAVERNIVGKVLEKIEAAGFRIVGMKKIQLSKKEAEGFYYVHSERPFFGDLCSFMSRSPVVVLALERENAIAKWREVMGATNPANADAGTIRKEFGLSIEENTVHGSDSPESAAFEIPYFFSQLELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SA3</accession>
    <name>Q39SA3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2653</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511808.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2653"/>
    <dbReference type="EnsemblBacteria" id="ABB32871">
        <property type="protein sequence ID" value="ABB32871"/>
        <property type="gene ID" value="Gmet_2653"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2653"/>
    <dbReference type="HOGENOM" id="CLU_737243_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223053" evidence="1">
        <location>
            <begin position="24"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="375" mass="41194" checksum="B508CE9E3E33A535" modified="2005-11-22" version="1">MGRFFVSSAMVVVLFVSVSVSHARMTDADRNALLGEIFKLETAKEKIVAEIRKFDDAIKKSAASISKSETIIGLARQKGNAQAEAVAGKALAEAKASQSRSLKNKSDAELVLRRLERTLSLAKSGDKNIEAIREQVEFETQYATWEKKQQQLIQQRLQEPNKTAGAIQRSLMANVPPLPGKTFSQLQSGDVLLIEPEDGRLKGVNPITLGDNAATGGNKSFASHTVIYLKEVNGTKLFLDNQPGEGPRIITEIDFQNRYGHRGMDVATLGKLAEPLRNDEGEGLFRAAMEMHKKNADKTANSWWGDTNYGVVGKDEVVCSEADWALLKNAGKFLPKSSDRAKVEHGIDLSPADYYNSPYFVVTPLQMHKNDGNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SB3</accession>
    <name>Q39SB3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_2642</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511819.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2642"/>
    <dbReference type="EnsemblBacteria" id="ABB32861">
        <property type="protein sequence ID" value="ABB32861"/>
        <property type="gene ID" value="Gmet_2642"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2642"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_127_1_7"/>
    <dbReference type="OMA" id="FSLIRVW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="545"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="828"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="950"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1096"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="775"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="469"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="877"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="999"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1216" mass="135370" checksum="4D70225F87534B58" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SK0</accession>
    <name>Q39SK0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513479.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2555"/>
    <dbReference type="EnsemblBacteria" id="ABB32774">
        <property type="protein sequence ID" value="ABB32774"/>
        <property type="gene ID" value="Gmet_2555"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2555"/>
    <dbReference type="eggNOG" id="COG3063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1150566_0_0_7"/>
    <dbReference type="OMA" id="TYMKRNK"/>
    <dbReference type="OrthoDB" id="1325560at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="243" mass="28242" checksum="81F890513CB94FFD" modified="2005-11-22" version="1">MYNFLISGGIALIAIIIIFIAAGSSAWWWAILVGLILFGASFLLISRVIMKKILEIMETANRDIQAQRVDKAIRELKEAFKYGKWQMYVDGQINSQIGMIYFLKRDFSTAFPYLEKSFAKNWVSMGMLAVTYMKRNKRDKMKETFEKAVQWSPKESLLWALYAYCWTECDDIGQAKAVLERGLKKLPGDEKLKANLESLEETKKMKMKVYGEMWLQFHLERQGVVMKQQMAAMGGMKRRVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SP7</accession>
    <name>Q39SP7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidoglycan L,D-transpeptidase, YkuD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2505</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514642.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2505"/>
    <dbReference type="MEROPS" id="C82.A01"/>
    <dbReference type="EnsemblBacteria" id="ABB32727">
        <property type="protein sequence ID" value="ABB32727"/>
        <property type="gene ID" value="Gmet_2505"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2505"/>
    <dbReference type="eggNOG" id="COG3034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102842_0_1_7"/>
    <dbReference type="OMA" id="MIHGLPN"/>
    <dbReference type="OrthoDB" id="1654458at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223352" evidence="4">
        <location>
            <begin position="21"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="YkuD" evidence="5">
        <location>
            <begin position="39"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="175" mass="19387" checksum="A8CDEFFA79131A12" modified="2005-11-22" version="1">MRIRLLRLCAAALLGILAAAPDGRCRQDPDLASPPTVDRVVVYKSKRLLELRSGQNLIRSYRVALGRNPVGPKVRAGDFRTPEGIYRLDRRSLQSRFFRSIHISYPNTEDIATARKQGVSAGGDIMIHGLPTGFEDLGPSHASFDWTKGCIAVTNAEMTEIWHLVRNGTPIEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SV6</accession>
    <name>Q39SV6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512457.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2443"/>
    <dbReference type="EnsemblBacteria" id="ABB32668">
        <property type="protein sequence ID" value="ABB32668"/>
        <property type="gene ID" value="Gmet_2443"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2443"/>
    <dbReference type="eggNOG" id="ENOG5033HC3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_199499_1_0_7"/>
    <dbReference type="OMA" id="GFCGHEF"/>
    <dbReference type="OrthoDB" id="2061254at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="60" mass="6759" checksum="2093CD2932797C26" modified="2005-11-22" version="1">MIRCGFCGHEFPEEEGIRGCGRCGKTCRSVRCPKCFYENPPEPKVLKALKGILKKDGKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SZ3</accession>
    <name>Q39SZ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_2406</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512494.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2406"/>
    <dbReference type="EnsemblBacteria" id="ABB32631">
        <property type="protein sequence ID" value="ABB32631"/>
        <property type="gene ID" value="Gmet_2406"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2406"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_10_7"/>
    <dbReference type="OMA" id="NWFGGVY"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="18"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="288"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="385" mass="42509" checksum="CA25FC44D001C588" modified="2005-11-22" version="1">MFILKLLIRNAFRHKLRTTLTIVGVAIAIVAFGLLRTLVDLWYAGVEASSASRLITRNAISLVFPLPISYKDRIRQVPGVKDVSWGNWFGGIYKDEKNFFPNFAVEPKSYLAMYPEYVIDPSQVKAFALDRKGCIVGRKTAERFGWKVGDQVTLRGTIFPGQWDFVIRGIYRGAQKNTDETQLFFHWDYLNETVKKTIARRADQVGFYMISLTKPEQAAEVSLAIDAIFKNSLAETLTETEKAFQMGFVSMTEAILVAIQIVSYVVIVIIMVVAANTMAMTARERIAEYATLKTLGFGAIHIAGVVFGESIVIAMIGGIAGVACTFPAAHWIETELSQFFPVFSIAPQTIVMDLAAALVVGVVAGIFPTWRGATIGIADGLRRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T22</accession>
    <name>Q39T22_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514764.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2377"/>
    <dbReference type="EnsemblBacteria" id="ABB32602">
        <property type="protein sequence ID" value="ABB32602"/>
        <property type="gene ID" value="Gmet_2377"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2377"/>
    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046484_7_2_7"/>
    <dbReference type="OMA" id="CAERSEP"/>
    <dbReference type="OrthoDB" id="1719840at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002071">
        <property type="entry name" value="Thermonucl_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01123">
        <property type="entry name" value="TNASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223495" evidence="1">
        <location>
            <begin position="24"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="2">
        <location>
            <begin position="37"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="185" mass="20864" checksum="00C5616A839A4F95" modified="2005-11-22" version="1">MVKRGASIVAVLLTGLCYTPTNAHVVSAAGRDFAYTSTSGGRVTRVWDGDTVVITPPWGRSFTCRLYGIDAPETPGKGVPGQPHGAAAAAKLRKLVLGRDVAVKLTGERSYKRQIGIIMLDGVDVNQEMVRRGYAWAYVRYLRRPYVSDYLGAEQKARQARRGLWRDRNPMPPWEFRRMLRKWRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T76</accession>
    <name>RL28_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmB</name>
        <name type="ordered locus">Gmet_2323</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL28 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513297.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T76"/>
    <dbReference type="SMR" id="Q39T76"/>
    <dbReference type="STRING" id="269799.Gmet_2323"/>
    <dbReference type="DNASU" id="3739484"/>
    <dbReference type="EnsemblBacteria" id="ABB32548">
        <property type="protein sequence ID" value="ABB32548"/>
        <property type="gene ID" value="Gmet_2323"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2323"/>
    <dbReference type="eggNOG" id="COG0227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064548_7_0_7"/>
    <dbReference type="OMA" id="RINVCTS"/>
    <dbReference type="OrthoDB" id="2062238at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00373">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034704">
        <property type="entry name" value="L28p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026569">
        <property type="entry name" value="Ribo_L28/L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037147">
        <property type="entry name" value="Ribo_L28/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001383">
        <property type="entry name" value="Ribosomal_L28"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00830">
        <property type="entry name" value="Ribosomal_L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143800">
        <property type="entry name" value="SSF143800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00009">
        <property type="entry name" value="L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000007243" description="50S ribosomal protein L28">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00373"/>
        </source>
    </evidence>
    <sequence length="63" mass="6976" checksum="035CA1555FB7B8A1" modified="2005-11-22" version="1">MSRKCEICGKGPSFGNNVSHANNKTRTTWYPNLQKVKAVRNGSVQTIKVCTRCIRSGHVTKAI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T85</accession>
    <name>DER_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Der</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GTP-binding protein EngA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">der</name>
        <name type="synonym">engA</name>
        <name type="ordered locus">Gmet_2314</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">GTPase that plays an essential role in the late steps of ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513306.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T85"/>
    <dbReference type="SMR" id="Q39T85"/>
    <dbReference type="STRING" id="269799.Gmet_2314"/>
    <dbReference type="EnsemblBacteria" id="ABB32539">
        <property type="protein sequence ID" value="ABB32539"/>
        <property type="gene ID" value="Gmet_2314"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2314"/>
    <dbReference type="eggNOG" id="COG1160">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016077_6_2_7"/>
    <dbReference type="OMA" id="KFRFLEY"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00195">
        <property type="entry name" value="GTPase_Der"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031166">
        <property type="entry name" value="G_ENGA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016484">
        <property type="entry name" value="GTP-bd_EngA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032859">
        <property type="entry name" value="KH_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14714">
        <property type="entry name" value="KH_dom-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006485">
        <property type="entry name" value="GTP-binding_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03594">
        <property type="entry name" value="GTPase_EngA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51712">
        <property type="entry name" value="G_ENGA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_1000099126" description="GTPase Der">
        <location>
            <begin position="1"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 1">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EngA-type G 2">
        <location>
            <begin position="176"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="KH-like" evidence="1">
        <location>
            <begin position="352"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="56"/>
            <end position="60"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="122"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="182"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00195"/>
        </source>
    </evidence>
    <sequence length="439" mass="49603" checksum="C73923AFE19A4B33" modified="2005-11-22" version="1">MMPLVAIVGRPNVGKSTLFNRLVGRRKAIVDDMPGVTRDRNYETVTRFEAPFILIDTGGFEPVSEDRLLQQMREQSQLAMEEADVIIFLMDGRAGLTPSDVEVVEMLRRVKKPVFFVVNKVDGEKIENEAADFYTLGIGTLHTISAEHNRGVNDLMEEVVAALPKSSTRLDDEDITRIAVVGRPNVGKSSLVNRLLGFERVVANPTPGTTRDSVDTLFACNKKRYLLIDTAGIRRKGKTTQKLEKYSVVDSLRSIERADVVLIIINAEEGVTEQDERIAGYAFEAGKACIFVVNKWDTLAKDNSTLGKFVDQIKTEFKYLSFAPIVFVSAKSGQRINRVMEEVERVMAQYSKRVSTSDLNRVFSEAVEKHHAPLSHGRRVKFYFATQVGTKPPTFVLFTNQPEGVHFSYERYLMNKFREAFDFTGSPLKIIFRGRDRRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TC0</accession>
    <name>Q39TC0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase, bacteriophage P4-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2279</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366032.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2279"/>
    <dbReference type="EnsemblBacteria" id="ABB32504">
        <property type="protein sequence ID" value="ABB32504"/>
        <property type="gene ID" value="Gmet_2279"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2279"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_0_4_7"/>
    <dbReference type="OMA" id="GVRAIYN"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038488">
        <property type="entry name" value="Integrase_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025166">
        <property type="entry name" value="Integrase_DNA_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13356">
        <property type="entry name" value="Arm-DNA-bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="208"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="414" mass="47599" checksum="FFB1D3F72C2E5A71" modified="2005-11-22" version="1">MSTQFSDKFIQNLKPEAKKYYIRESRGFAIVVHPSGIKNPKGTKTFLYIYTINGKRKELKLGNYPEVTLKDARIKHGEAYARLVNGEDPVTPPVIKAEPQDENLTFGHFTELYLQWSKDNHSPKWHNTIKCALNKDALPVWEYTLIASIKRRDAIAFLENVARRGIQVINLHKATSSVFDYALEREYIESNPMAGLKAKTIPALKPKARERFLSDSEIKHVWKAIDEGPGYDETKRALKLIMVTAQRPGEVAAMHRREIQTGVGKPRCKICKRCGWWTIPAERMKNGEEHRIYLTPTALELIGDAEGYIFPSPQDGQPINRNSLSQLVSRERNNKKPNGEMYPPYYGLPEWTPHDLRRTARTLLARVGVPEEHAEEVLSHKKEGLVDRYNRHDYMEEKKEALIKLEAELMKLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TE0</accession>
    <name>Q39TE0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">etfB-3</name>
        <name evidence="4" type="ordered locus">Gmet_2258</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366013.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2258"/>
    <dbReference type="EnsemblBacteria" id="ABB32484">
        <property type="protein sequence ID" value="ABB32484"/>
        <property type="gene ID" value="Gmet_2258"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2258"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_2_1_7"/>
    <dbReference type="OMA" id="ADLNEWD"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="22"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="271" mass="29434" checksum="89F261BB3F7E0132" modified="2005-11-22" version="1">MLIVVCIKQVPDTTQVQIDPVTNTLVREGIPFIVNPYDTHALEEALRLKDRFGYRVAALSMGPPNAEATLKKALALGVDRAILLSDRVFGGADTLATSNVLSAAIRKLHDEVDKVSLVLCGKQTIDGDTAQVGPGIASRLNFRQLTLVDRIENLDAAGGKIRVSRKLEGRHEIVETTLPAMLTVVRELNRPRYPKVSMRLAAAEATVEVWNNQTLGLDEQSIGLKGSPTWVSKIFSPERAKGEILGDGIAEPAAATRMLIDRLLSKDLLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TK0</accession>
    <name>Q39TK0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365953.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2197"/>
    <dbReference type="EnsemblBacteria" id="ABB32424">
        <property type="protein sequence ID" value="ABB32424"/>
        <property type="gene ID" value="Gmet_2197"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2197"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_2_3_7"/>
    <dbReference type="OMA" id="DIIMGCV"/>
    <dbReference type="OrthoDB" id="287662at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="6"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="280"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="358"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="402" mass="42172" checksum="9151BE44E061F7D6" modified="2005-11-22" version="1">MKNEAYIYDAIRTPRGKGKSDGSLHEVKPVTLLGDLLNELKVRNNLDTSQVEDIVIGCVTPLGDQGGNIAKTAALYAGWDDVVAGFQLNRFCASGLEAVNLAAMKVISGWEDLVVAGGVESMSRVTISSDGGALGLDPETSLKTGFIPQGVSADLIATLEGFSREDVDAFALESQKKAAEASEKGHFSKSLVPVKDRNGLTILGHDEFIRKSTTMEGLAQLKPSFEGVGAVGFDTVALRKYTQLKGINHVHTPGNSSGIVDGAAAVLVGSSAKGKELGLTPRGRVVAGVITSCEPTIMLTGPTAATRKVLQKAGLKISDIDLFEVNEAFAAVVMKFRKDLDIPAEKINVNGGAIAMGHPLGASGAMILGTVLDELERRRLRYGLCTLCVGGGIGIATIVERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TK9</accession>
    <name>Q39TK9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclopropane-fatty-acyl-phospholipid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CFA/CMAS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2187"/>
    <dbReference type="EnsemblBacteria" id="ABB32415">
        <property type="protein sequence ID" value="ABB32415"/>
        <property type="gene ID" value="Gmet_2187"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2187"/>
    <dbReference type="eggNOG" id="COG2230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026434_6_2_7"/>
    <dbReference type="OMA" id="QAEWAQK"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003333">
        <property type="entry name" value="Mycolic_cyclopropane_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003085">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="435" mass="48702" checksum="2F219714986B7DB5" modified="2005-11-22" version="1">MPGNHMVLESPHRADEDAVAALSFLEKVLAGYHPRDFEVRLWDGTLLKAEEKPRFTMVLNHPGVLRGMFLNPSQITLGEAFVRKDFDIEGDVVAAFALGDYLMGLHWGILDRFRMGRDLFTLPATAKPSRPGHASAHLSGSVHCKKRDSQAIAFHYNVSNDFYRLWLDERMVYSCAYFTSTSDELDAAQERKLDYICRKLRLKPGERLLDIGCGWGGLVLHAARNYGVKAHGITLSRPQAELAGERIRAAGLEDSCRVEVKDYRELEGQGIYDKIVSVGMFEHVGKARLEEYFARAFRLLGTGGAFLNHGIAAGQGYCPDDDNSFIDRYVFPDGELLPVDVTLHAAAAAGFEARDLESLREHYALTLRHWIKRLDAAATEAFIAASETTFRVWRLYMAGSAHAFDCNRINIYQALLAKPDKGKSGQPLTRADWYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TL4</accession>
    <name>Q39TL4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Undecaprenyl-diphospho-oligosaccharide flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2181</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365939.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2181"/>
    <dbReference type="EnsemblBacteria" id="ABB32410">
        <property type="protein sequence ID" value="ABB32410"/>
        <property type="gene ID" value="Gmet_2181"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2181"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026911_5_2_7"/>
    <dbReference type="OMA" id="MISWNTV"/>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="330"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="482" mass="53720" checksum="AEC655E2A8C0DC1D" modified="2005-11-22" version="1">MHRELIAKTVNNIGYNSIATILAAIIQFVTTIYLARILTPQDYGIVGFAQIFSNFMIQFCDFGINNAVVQKKEIDSTTLYTAFTLKVILSLIIFALIIIAAPLSYYFNGQHEIPTVIRALSLNFLISIFIFLPQVVLTRNLDYKKLVGPQTLALVGSSICSVYMAYLGFGYWSVVGASLLSNLLNAAMLVIIKPVSLRVVFDSSIARQLLGFGWSLLLPGIIVFVIFNTDNFLIGSLSGIEQLGYYSIAFNWGSMVCVLMGGMFHKVLFPTFSKLQYETSSMKKAYLTSLQYIAFLAVPANAILFIEGREFLFYILGRGTDRWLPAVITFQIFCLYGVLRSLLEPIGNVVMGIGKPQLFMKAILIVTVVELSLIYPAINYYGIEGVAIAVTLAYATQYFVYIPIIKREINVDLAEFVDVIKLPIASVVVMGIAMTLLKQAIHMTPVLLIINSVFGIIVYLVFFILADRGKLFREIRTVFLHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TQ9</accession>
    <name>Q39TQ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-hydroxybenzoyl-CoA reductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pcmT</name>
        <name evidence="2" type="ordered locus">Gmet_2136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513069.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2136"/>
    <dbReference type="EnsemblBacteria" id="ABB32365">
        <property type="protein sequence ID" value="ABB32365"/>
        <property type="gene ID" value="Gmet_2136"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2136"/>
    <dbReference type="eggNOG" id="COG1529">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001681_2_1_7"/>
    <dbReference type="OMA" id="QDPAPIG"/>
    <dbReference type="OrthoDB" id="117507at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017607">
        <property type="entry name" value="4hydrxbenzoyl-CoA_Rdtase_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000674">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036856">
        <property type="entry name" value="Ald_Oxase/Xan_DH_a/b_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016208">
        <property type="entry name" value="Ald_Oxase/xanthine_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008274">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037165">
        <property type="entry name" value="AldOxase/xan_DH_Mopterin-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11908">
        <property type="entry name" value="PTHR11908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01315">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02738">
        <property type="entry name" value="Ald_Xan_dh_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01008">
        <property type="entry name" value="Ald_Xan_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54665">
        <property type="entry name" value="SSF54665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56003">
        <property type="entry name" value="SSF56003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03194">
        <property type="entry name" value="4hydrxCoA_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ald_Xan_dh_C" evidence="1">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="768" mass="84672" checksum="220EC5A200CE177C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TY3</accession>
    <name>Q39TY3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514041.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2062"/>
    <dbReference type="EnsemblBacteria" id="ABB32291">
        <property type="protein sequence ID" value="ABB32291"/>
        <property type="gene ID" value="Gmet_2062"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2062"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_43_6_7"/>
    <dbReference type="OMA" id="EAENEWG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="147"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="366" mass="39843" checksum="007537861EAC0572" modified="2005-11-22" version="1">MKTLTVQSQKGMSSDHLNESDRELSMGTYSGEAFLTNSTVVVNDTDSMDKPASALVVRREGIRSFAHAPITVEGKPVGILSAFSKSMKGIFTDEFVELFTNLAGQIGIALRNALQAEKLIQAKEHEKEMQIARTIQMGLLPTRAPEVAGISLAGTCVPAREVGGDYYDFLVRGARGLDLVIADVSGHNVGAALLMAEVRTIIQAEAKIVRGPGEILCVLNDFLYEDLTRAELFITMFYLNYDAGTRLLSFASAGHNPPILRRSGSRACEYLDAEGLILGIKRNVTFEEKQVRLEPGDLLLLYTDGITEAANPAGELFGEDRLCSLIAEYHALHPQQIIDNLLAQVRSFAANQNLTDDVSLVVLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U54</accession>
    <name>Q39U54_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor histidine kinase cyclic nucleotide phosphodiesterase, GAF, GAF and HD-GYP-related domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512959.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1991"/>
    <dbReference type="EnsemblBacteria" id="ABB32220">
        <property type="protein sequence ID" value="ABB32220"/>
        <property type="gene ID" value="Gmet_1991"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1991"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368723_0_0_7"/>
    <dbReference type="OMA" id="RENDDIH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="202"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="567"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="755" mass="84935" checksum="FC6882EC3759F3CE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U66</accession>
    <name>Q39U66_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytidylate kinase-like domain phospholipid-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512972.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1979"/>
    <dbReference type="DNASU" id="3739201"/>
    <dbReference type="EnsemblBacteria" id="ABB32208">
        <property type="protein sequence ID" value="ABB32208"/>
        <property type="gene ID" value="Gmet_1979"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1979"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065155_0_0_7"/>
    <dbReference type="OMA" id="FIHFYFD"/>
    <dbReference type="OrthoDB" id="1962890at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014004">
        <property type="entry name" value="Transpt-assoc_nodulatn_dom_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00749">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="199"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="273" mass="31080" checksum="D9E5F66E9935860E" modified="2005-11-22" version="1">MAIITISREMGTGAYLIAREVAKRLKYTLVDGAKIAELAPQYGLDREIFNRVDEKPPVYITAEDRLQAAHLNTIEIIMLDCARKGNVILYGRGSQDLLADVENILRLRFVASFEDRVESLSEREWIDPELARVLIRKSDHQRGGFIHFYFNRDWNDTLGYDLVFNTSRMSQGAIVESIVAAAKDPRLKNGEDKTREIVDDIILCKKIETELFRSSTIENLHFKISAQKDVVLLSGHVYSDSEREDVLRIVAGVKGVTSIEDDLQVVSYKPYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U84</accession>
    <name>Q39U84_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Protease, S2P-M50-like family 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Gmet_1961</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511883.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1961"/>
    <dbReference type="EnsemblBacteria" id="ABB32190">
        <property type="protein sequence ID" value="ABB32190"/>
        <property type="gene ID" value="Gmet_1961"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1961"/>
    <dbReference type="eggNOG" id="COG1994">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086979_1_1_7"/>
    <dbReference type="OMA" id="HEIMHGL"/>
    <dbReference type="OrthoDB" id="1401629at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06158">
        <property type="entry name" value="S2P-M50_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044537">
        <property type="entry name" value="S2P-M50-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M50" evidence="15">
        <location>
            <begin position="134"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB32190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="226" mass="24879" checksum="FFCF74336406FA3F" modified="2005-11-22" version="1">MEQFFLKFSIMLVPALMAITCHEVSHGFVADRLGDRTARFMGRLTLNPLKHLDILGTLMIFLVGIGWAKPVPVNFHNLRNPKRDMIWVAGAGPVTNFVLALFSALIMRGLAALGAGFPDGSHALTFLDPLILMTAFSVYINLLLCIFNLIPVPPLDGGRVAVGLLPYRQAEMLARVEPYGMIIIILLVFFTNIFSSVISPILDMGIRILAGPQSGLVYSVTHFLMR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-23" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U97</accession>
    <name>TPIS_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Triosephosphate isomerase</fullName>
            <shortName evidence="1">TIM</shortName>
            <shortName evidence="1">TPI</shortName>
            <ecNumber evidence="1">5.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Triose-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tpiA</name>
        <name type="ordered locus">Gmet_1948</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365891.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39U97"/>
    <dbReference type="SMR" id="Q39U97"/>
    <dbReference type="STRING" id="269799.Gmet_1948"/>
    <dbReference type="EnsemblBacteria" id="ABB32177">
        <property type="protein sequence ID" value="ABB32177"/>
        <property type="gene ID" value="Gmet_1948"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1948"/>
    <dbReference type="eggNOG" id="COG0149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024251_2_3_7"/>
    <dbReference type="OMA" id="QEVCGAI"/>
    <dbReference type="OrthoDB" id="1266295at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00147_B">
        <property type="entry name" value="TIM_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022896">
        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020861">
        <property type="entry name" value="Triosephosphate_isomerase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="PTHR21139"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="SSF51351"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00419">
        <property type="entry name" value="tim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00171">
        <property type="entry name" value="TIM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000307472" description="Triosephosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="active site" description="Electrophile" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="167"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00147"/>
        </source>
    </evidence>
    <sequence length="251" mass="27116" checksum="FBE8AAF41F111832" modified="2005-11-22" version="1">MRTPIIAGNWKLFKKSSEAQDFVAELIPLVQKTTDVEIVIAPVFTVLSAVKRAIADCNIMLSAQDCFWEEEGAFTGEISPGMLVDAGCSHVIIGHSERRQYFGETDETVNRKIKAAITAGLTVLFCIGETLAEREADKTFEVLRTQIENGLAGLARGDLAKIVIAYEPVWAIGTGKTATDEQAQIAHAFIRKVVGELFTVQIAETIRILYGGSVKPENVRGLMNQPDIDGALVGGASLKADSFGAIVNYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UB9</accession>
    <name>Q39UB9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Energy-dependent translational throttle protein EttA</fullName>
            <ecNumber evidence="7">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Translational regulatory factor EttA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ettA</name>
        <name evidence="10" type="ordered locus">Gmet_1926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="7">Associates with ribosomes and polysomes.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511917.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1926"/>
    <dbReference type="EnsemblBacteria" id="ABB32155">
        <property type="protein sequence ID" value="ABB32155"/>
        <property type="gene ID" value="Gmet_1926"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1926"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_7"/>
    <dbReference type="OMA" id="ISYKPQY"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045900">
        <property type="term" value="P:negative regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00847">
        <property type="entry name" value="EttA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022374">
        <property type="entry name" value="EttA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43858">
        <property type="entry name" value="PTHR43858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03719">
        <property type="entry name" value="ABC_ABC_ChvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="2 7" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="10"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="327"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Arm" evidence="7">
        <location>
            <begin position="98"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="PtIM" evidence="7">
        <location>
            <begin position="245"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <begin position="359"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="559" mass="62640" checksum="AE8A61465E11E3F2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UM1</accession>
    <name>Q39UM1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ACT domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1824</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512021.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1824"/>
    <dbReference type="EnsemblBacteria" id="ABB32053">
        <property type="protein sequence ID" value="ABB32053"/>
        <property type="gene ID" value="Gmet_1824"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1824"/>
    <dbReference type="eggNOG" id="COG4747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136790_2_1_7"/>
    <dbReference type="OMA" id="INIEYLY"/>
    <dbReference type="OrthoDB" id="1670797at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045739">
        <property type="entry name" value="ACT_dom_pair"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19571">
        <property type="entry name" value="ACT_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="143" mass="15756" checksum="576EBDB3F3701E1F" modified="2005-11-22" version="1">MNVEQISIFIENKSGRLAEITKVLGDAGVNIRALSLADTSDFGILRLIVNDRETAKQVLKERGFTVSKTEVVAVEVPDRPGGLSQILQALDRDQINVEYMYAFVERCGENAVIIFRFDETAKAISTLTGNGFTVLKGARLYAM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UT4</accession>
    <name>COAD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphopantetheine adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dephospho-CoA pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantetheine-phosphate adenylyltransferase</fullName>
            <shortName evidence="1">PPAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaD</name>
        <name type="ordered locus">Gmet_1759</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19801"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57328"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="2.7.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial CoaD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513345.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UT4"/>
    <dbReference type="SMR" id="Q39UT4"/>
    <dbReference type="STRING" id="269799.Gmet_1759"/>
    <dbReference type="EnsemblBacteria" id="ABB31990">
        <property type="protein sequence ID" value="ABB31990"/>
        <property type="gene ID" value="Gmet_1759"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1759"/>
    <dbReference type="eggNOG" id="COG0669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100149_0_1_7"/>
    <dbReference type="OMA" id="EFQMALM"/>
    <dbReference type="OrthoDB" id="1846503at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00355"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004595">
        <property type="term" value="F:pantetheine-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02163">
        <property type="entry name" value="PPAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00151">
        <property type="entry name" value="PPAT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001980">
        <property type="entry name" value="PPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21342:SF1">
        <property type="entry name" value="PTHR21342:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01020">
        <property type="entry name" value="LPSBIOSNTHSS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01510">
        <property type="entry name" value="coaD_prev_kdtB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000011150" description="Phosphopantetheine adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="125"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00151"/>
        </source>
    </evidence>
    <sequence length="163" mass="18314" checksum="ED0E12B842C213AE" modified="2005-11-22" version="1">MPRKVAVYPGSFDPITYGHLDIIDRGLRIFDEIIVAVARNSAKNSLFSIDERVDMIQRVLADNVRARVDTFDGLLVDYVLSQNATVIIRGLRAISDFEYEFQIAQMNRSISQDVETLFMMTSVPFGYLSSSIVKEVSSLNGPIDGLVPPLVREALKDKFSKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UV3</accession>
    <name>Q39UV3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513365.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1740"/>
    <dbReference type="EnsemblBacteria" id="ABB31971">
        <property type="protein sequence ID" value="ABB31971"/>
        <property type="gene ID" value="Gmet_1740"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1740"/>
    <dbReference type="eggNOG" id="ENOG50302T2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_993091_0_0_7"/>
    <dbReference type="OMA" id="HDGIMDE"/>
    <dbReference type="OrthoDB" id="946090at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="282" mass="31931" checksum="0BDA3B32F2C1C9C7" modified="2005-11-22" version="1">MPRLPGNSALVDAAGRVLHSLREINFLSQVERERFYVGILPPRLFAYLGISPQTLCGADGLRRIKVIAPEGIGIARIEVKAHPADTDTAFFLELADTHYGQMELSFCIIADPETPRYYVDKDAAGRDNCFTTLGRNIPEELRAMEAGLFPNQTRRGLHLFGEFFPIFERFVDSLGMEMIVAEPLTYDNAIRYEKYGFDYITGKRLMLEIDQEFRRGGILFGRLDGSNPFRMPGAERTVRGRSWAIHDGIMDEPWDEVRIYKTVGEHAGIDTFPDRNNEGGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UZ3</accession>
    <name>Q39UZ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain iron-sulfur cluster-binding oxidoreductase with cobalamin-binding-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514154.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1700"/>
    <dbReference type="EnsemblBacteria" id="ABB31931">
        <property type="protein sequence ID" value="ABB31931"/>
        <property type="gene ID" value="Gmet_1700"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1700"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_5_1_7"/>
    <dbReference type="OMA" id="PQPMLGI"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025274">
        <property type="entry name" value="DUF4070"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13282">
        <property type="entry name" value="DUF4070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="157"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="434" mass="48965" checksum="3EEF03B02816EDEA" modified="2005-11-22" version="1">MKSRPRLLLVYPATHKLGWVRRFQLPSLSLKQVAAVTPPEWEVVMADEVHEDVPFGEKFDLVGITAMTHQAVRAYEIADRFRAQGVPVVLGGIHPTVLPEEAQAHADAVLIGEAEPVWAKLLDDFLAGRLAPLYRAPIPTDDRLVIPWSRRDILAGRQYLTTQTVQASRGCPYDCPFCTVTPYFGRTFRYRNPDDVLAELRSFEGKLMVFVDDNILGDPVRAKPILEGMAGMNLRWGGQANLRFAEDPELVKLVARSGCIGIFVGIESVTGPHANHAKTGNGSSQIDLVKRVRDAGIVLEASMIFGFDDHDEGIFERTVRFLEECAPSIPTFNVLTPYPGTSLFKQFDREGRLLHKDWSRYDHGQVVFRPKQMTPERLYRGWQEARWEAYRLPAIASRVMKGKGKLVNLAYNFLRRGGIERPDRIVHIREVAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UZ9</accession>
    <name>Q39UZ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">3-oxoacyl-(Acyl carrier protein) reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabG-1</name>
        <name evidence="1" type="ordered locus">Gmet_1694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514160.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1694"/>
    <dbReference type="EnsemblBacteria" id="ABB31925">
        <property type="protein sequence ID" value="ABB31925"/>
        <property type="gene ID" value="Gmet_1694"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1694"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="ITYNSRA"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="245" mass="25470" checksum="A42122C4345F103E" modified="2005-11-22" version="1">MEFAGNTIVVTGGTRGIGRAIALRFAREGARVFAAYLRNENAAREVAAEAAGLSGEIVTLQADVSTQEGAQGLIETAAASGTIDILINNAGIIRDGYLAMMADDDWDAVIRGNLYPLFHCCKWGIRKMMANRRGAIVNVSSISGIAGTAGQTNYAASKGGIISFTKALARETGPMGIRVNAVVPGLIETEMIAGMKRDMVDRIVAGAALGRLGTTCEVADAVAFLASDRATYITGQSLVVDGGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V00</accession>
    <name>Q39V00_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain iron-sulfur cluster-binding oxidoreductase with cobalamin-binding-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514161.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1693"/>
    <dbReference type="EnsemblBacteria" id="ABB31924">
        <property type="protein sequence ID" value="ABB31924"/>
        <property type="gene ID" value="Gmet_1693"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1693"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_5_7"/>
    <dbReference type="OMA" id="PFDEEFA"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="180"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="467" mass="50544" checksum="10EDA95F4DD007E6" modified="2005-11-22" version="1">MNVLLVSVNREHAPYPVFPLGLACLAGPLRAAGHRLSVLDLCFAADPEEATRQALAEFSPDVVVLSLRNIDNVTYPGSRSYLSGVRDVVAICRERAAVVVGGSGFSLMPREVLAYLGADYGVVGEGEDVLPRLLARIAAGEGGDGLPGVVARENAGFLPPHPVQAIGTPLRGLFQVERYHREGGMANIQTKRGCPFSCIYCTYPLLEGERMRLRPVADIIAEIGDLVDVHGVSYLYFVDDIFNYPLEFALELCRAMSAARLPVAWSAFINPDFLPPQLLDAMLAAGCDALEFGTDSGSPVMLRNLRKSFGIEKVREASRLCREAGVDFAHYILFGGPGETPATIAESFALMDEVAPTAVIAMTGIRIFPGTAIYRQALADGLITPETDLLRPAFYIAPTIADTLCELVREEALKRTNWVVPGLEITANDAMLEALRHFAGPGPLWKMLKLLGRRRGSVPSPWSHSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V43</accession>
    <name>Q39V43_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux pump, RND family, outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1650</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511413.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1650"/>
    <dbReference type="EnsemblBacteria" id="ABB31881">
        <property type="protein sequence ID" value="ABB31881"/>
        <property type="gene ID" value="Gmet_1650"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1650"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022604_2_0_7"/>
    <dbReference type="OMA" id="GTRWRQY"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223422" evidence="3">
        <location>
            <begin position="20"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="364"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="499" mass="55539" checksum="13A15A531E84F23E" modified="2005-11-22" version="1">MKRMCAALCLCLAAVPASAAEGQISLPLAEAVRSAVEKNLDVKAELYNPAMAQADIRKNEGIYDTTLRLTTDFNYSVTEPASSFLTGSLTNRQKTFDINPGISQLIPIGGTLGLTFNNTYNSNNSTRSFNNYWNSDLTVNLTQPLLKNFGREPTELAIMVARNSKGESLERFRTTLSDTVARVRNEYFKLYSLRGDLEVKTTSLLLARKILDDTKARVKAGVLPAMEILNAEFGVASREKDLIDAEKAVRDQNDVLRVLLQLTGRDEIVPVDMPTKEPFAVNEKEMVKRALDNRSEIREQLAALKSRELEMRVAHNRTLPDLNLSASAALTGLDSHYNRDMEKIGSADYPVWGVGLQFAYPLGNNAAENDYIRSKLRLEQARTQVRSLEANVENDVKAAIRGVESGYKQIDVTERGRAFAEERLRSFIKKNEVGLATTKDVLDVENDLAAAKINQINALVGYTDAITQLWRTTGEILDRTGVQLSDTEGDSLYERHVHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V93</accession>
    <name>Q39V93_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="11" type="synonym">fabH-2</name>
        <name evidence="11" type="ordered locus">Gmet_1599</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511466.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1599"/>
    <dbReference type="EnsemblBacteria" id="ABB31831">
        <property type="protein sequence ID" value="ABB31831"/>
        <property type="gene ID" value="Gmet_1599"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1599"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_3_1_7"/>
    <dbReference type="OMA" id="WGSEGDK"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="10">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="9">
        <location>
            <begin position="237"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="254"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="326" mass="35239" checksum="AC9DA996B14706AB" modified="2005-11-22" version="1">MARARIIGTGSAVPEMIRTNFDLEKMVDTTDDWITTRTGIRERRIAAEGEYTSTFATRAAERALEMAGVTAEEIDLLIVATVTPDFPFPSTACIVQSNIGAKRAAAFDVSAACSGFLYGLSLADNAIRSGGASKALIIGAEVLSRVIDWTDRNTCLLFGDGSGAVVVEACESEQGVLSTHLHSDGSYWELLYQPGCGNRNPAVQKTLDERKNFLRMQGNEVFKLAVRAMEDAALQALEKNGLTPSDISIFIPHQANRRIIDAIGKRLGLSDDKVYVNLDRYGNTSSASIPLALDEANRGGRINEGDIVLFDAFGGGLTWASVLLRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V98</accession>
    <name>Q39V98_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Leucyl aminopeptidase AmpS, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_1594</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511471.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1594"/>
    <dbReference type="EnsemblBacteria" id="ABB31826">
        <property type="protein sequence ID" value="ABB31826"/>
        <property type="gene ID" value="Gmet_1594"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1594"/>
    <dbReference type="eggNOG" id="COG2309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057697_0_0_7"/>
    <dbReference type="OMA" id="CNANIPT"/>
    <dbReference type="OrthoDB" id="689314at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035097">
        <property type="entry name" value="M29_N-terminal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="368" mass="41951" checksum="D754762983C7A612" modified="2005-11-22" version="1">MFDPRVRQLAEVLVTYSTRVKKGDVVLINASGTDCLPLVKELYSLCLARGAKYVEYSFHIPEIDRHFYNTATKSQLSFFPQHKLDFMKQVNVFISISGSPNSMVMAQANQKNMIAWSKVTRPIVDWRVKNTRWVITRYPTHGAAQEAKMSLEEYEEYLFAACCIDWEAESRKQEKLKRLMDKADTVRIKASDTDLSFSIRGLDGIKCDGRFNIPDGEVFTAPVRDSVEGHITYNCPTIYQGKEFNGVRLEFAKGRIVKASAPGMDDELNRILDTDEGARFIGEFAIGVNPNIRVPMRNILFDEKIFGSIHFTPGQCYDECDNGNRSAVHWDMVKLLKGDGEIWFDNHLIQKDGLFVHKDLVSLNPARE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VA3</accession>
    <name>TRUB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase B</fullName>
            <ecNumber evidence="1">5.4.99.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(55) synthase</fullName>
            <shortName evidence="1">Psi55 synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truB</name>
        <name type="ordered locus">Gmet_1589</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(55) in tRNA = pseudouridine(55) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42532"/>
            <dbReference type="Rhea" id="RHEA-COMP:10101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10102"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511476.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VA3"/>
    <dbReference type="SMR" id="Q39VA3"/>
    <dbReference type="STRING" id="269799.Gmet_1589"/>
    <dbReference type="EnsemblBacteria" id="ABB31821">
        <property type="protein sequence ID" value="ABB31821"/>
        <property type="gene ID" value="Gmet_1589"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1589"/>
    <dbReference type="eggNOG" id="COG0130">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032087_0_3_7"/>
    <dbReference type="OMA" id="ELQFIRW"/>
    <dbReference type="OrthoDB" id="1166299at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02573">
        <property type="entry name" value="PseudoU_synth_EcTruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01080">
        <property type="entry name" value="TruB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014780">
        <property type="entry name" value="tRNA_psdUridine_synth_TruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13767">
        <property type="entry name" value="PTHR13767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00431">
        <property type="entry name" value="TruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000229358" description="tRNA pseudouridine synthase B">
        <location>
            <begin position="1"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01080"/>
        </source>
    </evidence>
    <sequence length="304" mass="33273" checksum="5AFEBFB23BE555A1" modified="2005-11-22" version="1">MDGFIVIDKPAGLTSHDIIARVRRILGQKKAGHTGTLDPFATGVLPVAMGEGTKAIPFLDEAVKEYRATMVLGAATDTQDCTGRVEKEGDWTRLSVEAVREVFGAYIGKCKQIPPMYSAVKQGGVPLYRLARKGHEVEREPRDIEIHSLIIDRMELPRIEFTVSCSRGTYVRTLAHDMGERLGCGAHLSALRRTRSGPFDLSRAVTLDELASIKEQGAVDSLLLAPNEVLGHFPEIELSDEEVRKVYCGVPPRCHGRCEESSASQNDGKKVRLVQNGKLLAVAEIGQAESGNGNKSLRLIRVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VC9</accession>
    <name>Q39VC9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511504.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1561"/>
    <dbReference type="EnsemblBacteria" id="ABB31795">
        <property type="protein sequence ID" value="ABB31795"/>
        <property type="gene ID" value="Gmet_1561"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1561"/>
    <dbReference type="eggNOG" id="ENOG50343UD">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2034748_0_0_7"/>
    <dbReference type="OMA" id="VVMKVGN"/>
    <dbReference type="OrthoDB" id="1926902at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223337" evidence="1">
        <location>
            <begin position="26"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="122" mass="13149" checksum="FABCCBE8CCC38C53" modified="2005-11-22" version="1">MRRIAVVFGMFALSLVVFASFSAGAADKKAKSEVVMKVGNKVHLFHSGTADVKKEICPNDVITVYREIGGAKNPKSIEVGQVKVLSYVSAHYFEAEVVKGEVKPGDIAMKESAACLIQPVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VH1</accession>
    <name>Q39VH1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase, ABC1 domain-containing, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511548.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1519"/>
    <dbReference type="DNASU" id="3740119"/>
    <dbReference type="EnsemblBacteria" id="ABB31753">
        <property type="protein sequence ID" value="ABB31753"/>
        <property type="gene ID" value="Gmet_1519"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1519"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_9_3_7"/>
    <dbReference type="OMA" id="WGLGKRI"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1" evidence="1">
        <location>
            <begin position="134"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="483" mass="55799" checksum="1C205167EDE3C2C6" modified="2005-11-22" version="1">MKPEKRHATESMTMEALLDLLPKDAATDPTGRRLAELVTRIATKRVPVSSFSRIWNLGSLQARVTIGYVAYWLRSRFADSDEKQRLRNEAHLAAALRLFGTMGYLRGAVMKIGQLLANLPEVVPEEFAEVLSALHFEAPPMHFSLVRELFLDEFGREPEELFASFDRQAFAAASLGQVHRARLKSGEEVAVKIQYPGIARTIKADLRNLRLLLQPLCLTNDWQNTLDKLADIEQMLLMETDYEQEARFCREARLLFTTEDRVVVPRVFDDYSTKRVLTTEFLTGCHLDQFLAGNPSQAERDHFTTLLTVATMRIYYRLHWFCADPHPGNFIFMLDGRLGLIDFGCTRAMNGEEWRLICELEQAHQEEDAEQFDRVIARATLYDSPEAMGKEQLAVVRRNVLWNMEPWLKEGLFDFGDREFFMRGIDGLMELTRKRYTRGSPLYLWSTRFVLGGRAVCYQMRGRCEFQEIFRQESAWVCPEPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VI8</accession>
    <name>Q39VI8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-alpha-N-acetylglucosamine 3-alpha-N-acetyl-L-fucosaminyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511565.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1502"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="DNASU" id="3741633"/>
    <dbReference type="EnsemblBacteria" id="ABB31736">
        <property type="protein sequence ID" value="ABB31736"/>
        <property type="gene ID" value="Gmet_1502"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1502"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_11_2_7"/>
    <dbReference type="OMA" id="GNMGRCH"/>
    <dbReference type="OrthoDB" id="1591999at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13579">
        <property type="entry name" value="Glyco_trans_4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="215"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="420" mass="47037" checksum="D4D7A801FC613BDF" modified="2005-11-22" version="1">MHILFLTHYFPPEVNAPASRTYENARRWVRDGHHVTVITCAPNHPKGVIYPGYRNRWCQQEDLDGIRVLRVKTYLSANKGFAKRIANYLSYMLSSTVFSCLVRDIDVVVSTSPQFFCGLAGYFVSRARSAPWVVEIRDLWPESIIAVGAIRNRTVIDLLEGLETFMYRRADHVVAVTDAFKRHIAGRGVGRDRISVIKNGADLERFTSGPRENSFRREHGLEGKFVVSYVGTHGMAHGLNTIFETAEAMRSCEDIVFLLVGDGAEREPLLARKAELGLTNVLMLPQQPKERMPEIINASDACMVLLKKTDLFKTVIPSKIFEAMAMERPIILGVEGESREIVEEGCCGLCIEPENAAELADAIRRLRDDGKLADELGQNGRRFVSAVFNREVLARRYLETLSSMVPLPASTIGVIGKELP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VQ6</accession>
    <name>SYR_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arginine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginyl-tRNA synthetase</fullName>
            <shortName evidence="1">ArgRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argS</name>
        <name type="ordered locus">Gmet_1434</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB31668" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31668.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VQ6"/>
    <dbReference type="SMR" id="Q39VQ6"/>
    <dbReference type="STRING" id="269799.Gmet_1434"/>
    <dbReference type="EnsemblBacteria" id="ABB31668">
        <property type="protein sequence ID" value="ABB31668"/>
        <property type="gene ID" value="Gmet_1434"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1434"/>
    <dbReference type="eggNOG" id="COG0018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006406_0_1_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="PTHR11956"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="SSF55190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000242026" description="Arginine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="130"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="562" mass="62252" checksum="04F8CEB87823CC87" modified="2006-06-27" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VR0</accession>
    <name>Q39VR0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="4 7">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ugd</name>
        <name evidence="12" type="ordered locus">Gmet_1430</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>H2O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="4 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511638.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1430"/>
    <dbReference type="EnsemblBacteria" id="ABB31664">
        <property type="protein sequence ID" value="ABB31664"/>
        <property type="gene ID" value="Gmet_1430"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1430"/>
    <dbReference type="eggNOG" id="COG1004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_1_2_7"/>
    <dbReference type="OMA" id="CECLNLP"/>
    <dbReference type="OrthoDB" id="647136at2"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="11">
        <location>
            <begin position="325"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="155"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="255"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB31664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="450" mass="49386" checksum="167593D7A5901815" modified="2005-11-22" version="1">MKICVIGSGYVGLVAGTCFAESGNTVICVDVNQEKIEGLKQGILPIYEPGLKELVLRNSAEGRLSFTTDLASAVKESLICFIAVGTPPGEDGSADLQHVLAVAREIGRNMEGFKIIVDKSTVPVGTADKVRRAAQEELDRRGAAYEFDVVSNPEFLKEGAAIDDFMKPDRVVIGADNVRTAEIMKELYSPFMRKTNRLIVMDVHSAEMTKYAANAMLATRISFMNQIANLCERMGADVSAVREGIGSDSRIGYDFLFPGVGYGGSCFPKDVKALIKTAEECEYDFVLLKSVEEVNERQKAILIDKMIAHFSRDNGASPLAGKTIAIWGLSFKPRTDDMREAPSIVIISKLLEMGATVLAHDPEAVKEAKKIFGDRITYTSTNQYEILKGADALAIITEWNEYRNPDFERISASLTAPVIFDGRNLYNPRRMKEIGFTYHSIGRNGSAFTG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VR6</accession>
    <name>MUTS_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA mismatch repair protein MutS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mutS</name>
        <name type="ordered locus">Gmet_1424</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511644.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VR6"/>
    <dbReference type="SMR" id="Q39VR6"/>
    <dbReference type="STRING" id="269799.Gmet_1424"/>
    <dbReference type="EnsemblBacteria" id="ABB31658">
        <property type="protein sequence ID" value="ABB31658"/>
        <property type="gene ID" value="Gmet_1424"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1424"/>
    <dbReference type="eggNOG" id="COG0249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002472_3_1_7"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="15991at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00096">
        <property type="entry name" value="MutS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005748">
        <property type="entry name" value="DNA_mismatch_repair_MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="PTHR11361"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="SSF48334"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="SSF53150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="SSF55271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01070">
        <property type="entry name" value="mutS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000008063" description="DNA mismatch repair protein MutS">
        <location>
            <begin position="1"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="622"/>
            <end position="629"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00096"/>
        </source>
    </evidence>
    <sequence length="872" mass="96100" checksum="756D56A3BF95C812" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VV5</accession>
    <name>Q39VV5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513123.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1385"/>
    <dbReference type="EnsemblBacteria" id="ABB31619">
        <property type="protein sequence ID" value="ABB31619"/>
        <property type="gene ID" value="Gmet_1385"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1385"/>
    <dbReference type="eggNOG" id="COG4313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914528_0_0_7"/>
    <dbReference type="OMA" id="KDSKNEW"/>
    <dbReference type="OrthoDB" id="1168241at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025737">
        <property type="entry name" value="Phenol_MetA_deg_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13557">
        <property type="entry name" value="Phenol_MetA_deg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223338" evidence="1">
        <location>
            <begin position="25"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="304" mass="33012" checksum="D2E39CF65ADF338E" modified="2005-11-22" version="1">MKFSKRIIPLSLAALCTCAGLSWGADAPAAPKPFGPAISAFGPAGTGFPVGKLGVLLNYQYCETDGIRKGSSEINENVKLTKNVGVVKFRYGITEGLDVRTATPLYTVYKKNKLTGTGEHLGWIGDTAIALHKVLMNQSKGSMFDLAVDVGLVVPTTDVSSKSIDFVGNGAWGTGGAVGLTYSTGSHRLDQEIHVYTFTEGAHDYRKPMYVRSTTAWGYAVNNYFDMGAESQFDWNDASEKNGKSQNDTKNEWYAGPKVAFKYKPAGFAAGLAAMFPMVRWYEANTPSEGFRIELKLSKTFDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VZ2</accession>
    <name>Q39VZ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphatase/phosphohexomutase-related hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513160.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1348"/>
    <dbReference type="EnsemblBacteria" id="ABB31582">
        <property type="protein sequence ID" value="ABB31582"/>
        <property type="gene ID" value="Gmet_1348"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1348"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_7"/>
    <dbReference type="OMA" id="YHGRRPM"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="226" mass="24082" checksum="289C71C8C9EA87F5" modified="2005-11-22" version="1">MLSAVIFDFDGIIVDTEPLHYRAFQAILEPLGLGYAWEEYVNLYMGFDDRDAFREAFRVHGRTLNDHELELLIDRKAAAFQEIISSGVAPYPGVVELIRSINGTFPLALCSGALRCDILPILAGLGLSNAFDVMVTAEEVTASKPDPASYALAVERLAAAFVDRGILPGRCIAIEDTPAGIASATGAGIPVIAVTNSYPAEMLSGAVRVVDSLAGLALADIENLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W78</accession>
    <name>Q39W78_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Acetolactate synthase</fullName>
            <ecNumber evidence="4 8">2.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ilvB</name>
        <name evidence="12" type="ordered locus">Gmet_1260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>H(+) + 2 pyruvate = (2S)-2-acetolactate + CO2</text>
            <dbReference type="Rhea" id="RHEA:25249"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="2.2.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TPP enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.6" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512107.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1260"/>
    <dbReference type="EnsemblBacteria" id="ABB31496">
        <property type="protein sequence ID" value="ABB31496"/>
        <property type="gene ID" value="Gmet_1260"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1260"/>
    <dbReference type="eggNOG" id="COG0028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013748_1_2_7"/>
    <dbReference type="OMA" id="CFGTSGP"/>
    <dbReference type="OrthoDB" id="391134at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00055"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00059"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02015">
        <property type="entry name" value="TPP_AHAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012846">
        <property type="entry name" value="Acetolactate_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039368">
        <property type="entry name" value="AHAS_TPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000399">
        <property type="entry name" value="TPP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="PTHR18968"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00118">
        <property type="entry name" value="acolac_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00187">
        <property type="entry name" value="TPP_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TPP_enzyme_N" evidence="11">
        <location>
            <begin position="3"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_M" evidence="9">
        <location>
            <begin position="193"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="TPP_enzyme_C" evidence="10">
        <location>
            <begin position="393"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB31496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="566" mass="61484" checksum="9202F8DC08D33617" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WD4</accession>
    <name>Q39WD4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512167.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1203"/>
    <dbReference type="EnsemblBacteria" id="ABB31440">
        <property type="protein sequence ID" value="ABB31440"/>
        <property type="gene ID" value="Gmet_1203"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1203"/>
    <dbReference type="eggNOG" id="COG4420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077948_2_3_7"/>
    <dbReference type="OMA" id="YTAPMIM"/>
    <dbReference type="OrthoDB" id="1597938at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010406">
        <property type="entry name" value="DUF1003"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41386">
        <property type="entry name" value="PTHR41386"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06210">
        <property type="entry name" value="DUF1003"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="154" mass="17621" checksum="F92DAF98D7B86DF7" modified="2005-11-22" version="1">MKRPTFPAPYKHEHAPVKNVNEVITEQLTIGQKAADWIAARVGSWEFIIGQSVLLTLWALLNVTAWVRHWDPYPFILMNLVLSLQAAYTAPMIMMSQNRQAARDRIEAHNDYEVNLKAEVEVKEVLENLAAQNIAIAELQTMLETLLARQDDRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WL5</accession>
    <name>Q39WL5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513385.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1121"/>
    <dbReference type="EnsemblBacteria" id="ABB31359">
        <property type="protein sequence ID" value="ABB31359"/>
        <property type="gene ID" value="Gmet_1121"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1121"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_1_7"/>
    <dbReference type="OMA" id="HIGASKR"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="234" mass="26881" checksum="5EB983542721C403" modified="2005-11-22" version="1">MKHQVNDNNQSATPLTDRIFDVLQDSIIKGEIPAGSKISEPELAKTYGVSRGTLREALSRLEERHLVIRAPNHGARVISLSYEELIETYQVREVLGGLGCRLAVQNMTDSEIAELKKLLDEHEKSIAEDQGLSYYQEEGEFDFHYRILQGSRNKRLLAILDGGLYQLIRMYRYQFSTDSPRPLLALKEHRRIVDAIEERDEELAELLMRRHIRTARISVEERHKKAIAKDSGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WU5</accession>
    <name>Q39WU5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tungstate ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tupC</name>
        <name evidence="6" type="ordered locus">Gmet_1039</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513212.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1039"/>
    <dbReference type="EnsemblBacteria" id="ABB31279">
        <property type="protein sequence ID" value="ABB31279"/>
        <property type="gene ID" value="Gmet_1039"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1039"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="MGCEDID"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="247" mass="26632" checksum="26A7EAB8BC09B07B" modified="2005-11-22" version="1">MSIRYRLDSIQTSYDSRTVLDIGQLTLRAGRLYILTGANGAGKSTLLSHLALLTAPTSGEIVFEGETVLWSNSTLQRQRRDVTLVHQSPYLFTGSVAANVAYGLKLRGGHGDGLKQRVEEALALVGLAGFGHRRSRELSGGEAQRVALARALALETKVLLLDEPLANVDRNTSDLLENIISALPARGTTVVMTTHDPEHLERLKGERIHLAAGRLAAPQSFSTTSVEEGEIQPCRLSPKPATSFSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WY9</accession>
    <name>Q39WY9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UbiD family decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514686.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0993"/>
    <dbReference type="EnsemblBacteria" id="ABB31235">
        <property type="protein sequence ID" value="ABB31235"/>
        <property type="gene ID" value="Gmet_0993"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0993"/>
    <dbReference type="eggNOG" id="COG0043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_4_1_7"/>
    <dbReference type="OMA" id="IWPFTTV"/>
    <dbReference type="OrthoDB" id="1012819at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="612" mass="67018" checksum="4D1115AB949AD321" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WZ3</accession>
    <name>Q39WZ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514384.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0989"/>
    <dbReference type="EnsemblBacteria" id="ABB31231">
        <property type="protein sequence ID" value="ABB31231"/>
        <property type="gene ID" value="Gmet_0989"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0989"/>
    <dbReference type="eggNOG" id="ENOG50331TB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185100_0_0_7"/>
    <dbReference type="OMA" id="MQCQTVL"/>
    <dbReference type="OrthoDB" id="1959410at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="98" mass="10296" checksum="D8B0AC71C184ADEF" modified="2005-11-22" version="1">MQCQTVLPGTECTFWGKQGCIFTGGSCQIVVENCEGCERVVDGSIGKVCSAYPAPVKKWSAGICNFATHVKVEIASEELKVNPLKASKKASGGGGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XA0</accession>
    <name>Q39XA0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Undecaprenyl-diphospho-4-formamido-4-deoxy-L-arabinose deformylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arnD</name>
        <name evidence="2" type="ordered locus">Gmet_0882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513029.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0882"/>
    <dbReference type="EnsemblBacteria" id="ABB31124">
        <property type="protein sequence ID" value="ABB31124"/>
        <property type="gene ID" value="Gmet_0882"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0882"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084199_0_0_7"/>
    <dbReference type="OMA" id="KFLWKML"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="2"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="308" mass="34750" checksum="A38BD1831AAE61CE" modified="2005-11-22" version="1">MPTIALKIDVDTYVGTRDGVPRLLEIFDRFGIKGTFYFSMGPDNSGKAIRRIFTRKGFLRKMLRTRAPSVYGLRTLMYGVLLPPPIIADKVPHVLRETEARGHEVGIHCWDHVKWHDLLPWIPRNMIALELGRAFALFEEILNRRAKTTAAPGWTVTADSLEIQDALYLTYCSDSRGIHPFYPVMDDRRFHTLQIPTTLPTMDELLGENGITAETVNDHYLSLIQPGLNVHTIHAELEGGVLSPVFIDLLERLQAKGCRFVTLAEAAEEAHRGEIPCCRLAMGELLGRAGEVAIQGKMTREPRKKIRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XA5</accession>
    <name>Q39XA5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0877</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513023.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0877"/>
    <dbReference type="EnsemblBacteria" id="ABB31119">
        <property type="protein sequence ID" value="ABB31119"/>
        <property type="gene ID" value="Gmet_0877"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0877"/>
    <dbReference type="eggNOG" id="COG2983">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164634_1_0_7"/>
    <dbReference type="OMA" id="CCFEKIE"/>
    <dbReference type="OrthoDB" id="1653862at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008228">
        <property type="entry name" value="UCP006173"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37421">
        <property type="entry name" value="PTHR37421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="107" mass="12662" checksum="EB2418EAC1B4FEDA" modified="2005-11-22" version="1">MKQPDNHDAAWESLCRQCGLCCFEKIEDDSGTIFFTQTPCRYLDVATRQCVIYERRFEINPECVKLTEELVRELPWLHDDCAYRRALGIKRTRTTMNGRPKRSKTKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XA9</accession>
    <name>MNMA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-specific 2-thiouridylase MnmA</fullName>
            <ecNumber evidence="1">2.8.1.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmA</name>
        <name type="ordered locus">Gmet_0873</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + ATP + S-sulfanyl-L-cysteinyl-[protein] + uridine(34) in tRNA = 2-thiouridine(34) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:47032"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11726"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="Rhea" id="RHEA-COMP:11728"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:87170"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.8.1.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmA/TRMU family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.13" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513019.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XA9"/>
    <dbReference type="SMR" id="Q39XA9"/>
    <dbReference type="STRING" id="269799.Gmet_0873"/>
    <dbReference type="EnsemblBacteria" id="ABB31115">
        <property type="protein sequence ID" value="ABB31115"/>
        <property type="gene ID" value="Gmet_0873"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0873"/>
    <dbReference type="eggNOG" id="COG0482">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035188_0_0_7"/>
    <dbReference type="OMA" id="AVCTGHY"/>
    <dbReference type="OrthoDB" id="1054741at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01998">
        <property type="entry name" value="tRNA_Me_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00144">
        <property type="entry name" value="tRNA_thiouridyl_MnmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023382">
        <property type="entry name" value="Adenine_a_hdrlase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004506">
        <property type="entry name" value="tRNA-specific_2-thiouridylase"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00420">
        <property type="entry name" value="trmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000349647" description="tRNA-specific 2-thiouridylase MnmA">
        <location>
            <begin position="1"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="157"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with tRNA" evidence="1">
        <location>
            <begin position="312"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="1">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with tRNA" evidence="1">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Alternate" evidence="1">
        <location>
            <begin position="110"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00144"/>
        </source>
    </evidence>
    <sequence length="368" mass="40989" checksum="CAC2504D0A1B8469" modified="2005-11-22" version="1">MTEKARKRIVVAMSGGVDSSVTAALLKEEGHEVIGISMQVWDYSKFSAPEGEKFDTCCSLDDIHDARRVAEQIGIPFYVVNFEEEFQRLVIDDFVDEYFRGRTPNPCVRCNQRVKFELLLRKARELGADLLATGHYARIERGGDGLFHLLRGDDPGKDQSYFLFTLTQEQLARVTFPLGGMTKPEVRQLATRFGLRVAEKGESQEICFVPDNDYVRFLEDERGAGQLVGEIVDRAGTVLGHHEGTYRYTVGQRRGLGIAHPHPLYVVGVDAERRQVIVGPKEELLAPGLVATDVTWVIALATETLEAACKIRYRHHPVPCTVTVLAGNRAQVRFREPEKSVTPGQAVVFYHGDEVLGGGWIDAAMTEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XG5</accession>
    <name>Q39XG5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0817</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514404.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0817"/>
    <dbReference type="EnsemblBacteria" id="ABB31059">
        <property type="protein sequence ID" value="ABB31059"/>
        <property type="gene ID" value="Gmet_0817"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0817"/>
    <dbReference type="eggNOG" id="ENOG5033DGE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1989454_0_0_7"/>
    <dbReference type="OMA" id="KNEMTFK"/>
    <dbReference type="OrthoDB" id="1765676at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="128" mass="14285" checksum="7CACBBE849D81EB0" modified="2005-11-22" version="1">MSKKPEVTFKYIFTYDYNPVYVNGAHGGVSPRGDLVVNFYLERPPLPNEITHEVNPNGTIGAETGVEPEDFAQSLVRFVPTGVVLNYQTARELHHWLGEKVRELETLEQHKAAMRAAAQQPGGEGVQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XJ3</accession>
    <name>Q39XJ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aldehyde dehydrogenase family 11 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0789</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513534.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0789"/>
    <dbReference type="EnsemblBacteria" id="ABB31031">
        <property type="protein sequence ID" value="ABB31031"/>
        <property type="gene ID" value="Gmet_0789"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0789"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_0_1_7"/>
    <dbReference type="OMA" id="AFIGTHK"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="4">
        <location>
            <begin position="64"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="541" mass="59174" checksum="98EC05F9DF905A85" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XN3</accession>
    <name>Q39XN3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine protease, subtilase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0749</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365718.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0749"/>
    <dbReference type="EnsemblBacteria" id="ABB30991">
        <property type="protein sequence ID" value="ABB30991"/>
        <property type="gene ID" value="Gmet_0749"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0749"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_9_0_7"/>
    <dbReference type="OMA" id="FAFAWDT"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017315">
        <property type="entry name" value="Pep_S8A_subtilisin_pbac-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037901">
        <property type="entry name" value="Subtilisin_rel_Nmul_A1891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223423" evidence="6">
        <location>
            <begin position="31"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="140"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="587" mass="59750" checksum="8A57EF98A01D439D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XQ5</accession>
    <name>Q39XQ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0047 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30969.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514444.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0727"/>
    <dbReference type="EnsemblBacteria" id="ABB30969">
        <property type="protein sequence ID" value="ABB30969"/>
        <property type="gene ID" value="Gmet_0727"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0727"/>
    <dbReference type="eggNOG" id="COG0432">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096980_1_1_7"/>
    <dbReference type="OMA" id="WQHRHGS"/>
    <dbReference type="OrthoDB" id="1691156at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001602">
        <property type="entry name" value="UPF0047"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035917">
        <property type="entry name" value="YjbQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30615">
        <property type="entry name" value="PTHR30615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01894">
        <property type="entry name" value="UPF0047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004681">
        <property type="entry name" value="UCP004681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111038">
        <property type="entry name" value="SSF111038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00149">
        <property type="entry name" value="TIGR00149_YjbQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30969.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="132" mass="14819" checksum="21DCF2F5275530DA" modified="2012-10-31" version="2">MVRYLEIRSRAKAEFIDITSMVREQVRGSGVTCGICHIFVLHTTAGLTINEGADPAVQRDILTYLDRLVPRDPYFTHKEGNSDAHIKSTLTGTSLTVFFNEGKLLLGTWQSIYLCEFDGPRQRKVALKIVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XV5</accession>
    <name>Q39XV5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin, RelE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0677</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514068.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0677"/>
    <dbReference type="EnsemblBacteria" id="ABB30919">
        <property type="protein sequence ID" value="ABB30919"/>
        <property type="gene ID" value="Gmet_0677"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0677"/>
    <dbReference type="eggNOG" id="COG3668">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147162_4_0_7"/>
    <dbReference type="OMA" id="IYEESHT"/>
    <dbReference type="OrthoDB" id="2036309at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="108" mass="12400" checksum="A536317B1B4E2D0F" modified="2005-11-22" version="1">MPRRYAVHWARTAEQDLEAIIDYIAQDSIDAALRILAKLRDGAATLSSTPHRGRVVPELLAHGIPTYRELIIPPWRLMYRIGEGEVLVLALFDSRRNLEDILLERLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XW6</accession>
    <name>Q39XW6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0666</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514274.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0666"/>
    <dbReference type="EnsemblBacteria" id="ABB30908">
        <property type="protein sequence ID" value="ABB30908"/>
        <property type="gene ID" value="Gmet_0666"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0666"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_7"/>
    <dbReference type="OMA" id="QTGWMTS"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="127"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="199"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="248"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="325"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="406"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="618" mass="70577" checksum="8A03B7AE7314A444" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XY5</accession>
    <name>Q39XY5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenylate kinase</fullName>
            <shortName evidence="6">AK</shortName>
            <ecNumber evidence="6 8">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 10" type="primary">adk</name>
        <name evidence="10" type="ordered locus">Gmet_0647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from ADP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30889.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365702.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0647"/>
    <dbReference type="EnsemblBacteria" id="ABB30889">
        <property type="protein sequence ID" value="ABB30889"/>
        <property type="gene ID" value="Gmet_0647"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0647"/>
    <dbReference type="eggNOG" id="COG0563">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032354_1_2_7"/>
    <dbReference type="OMA" id="FHNRMRV"/>
    <dbReference type="OrthoDB" id="1491686at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00649"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:adenylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="PTHR23359"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADK_lid" evidence="9">
        <location>
            <begin position="127"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMP" evidence="6">
        <location>
            <begin position="30"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="126"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="85"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>structural</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30889.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="215" mass="23128" checksum="50C87EC79F16967A" modified="2012-10-31" version="2">MNLIFLGPPGAGKGTQANLLVGTYGIPQISTGDILRSAVANQTSLGITAKSYMDAGSLVPDEVVVGIVNERLAADDCAAGFILDGFPRTVAQADALGGMLQGAGRSIAHVISFEVDYAVLVDRLTGRRMCRACGRGFHVLYDRPSVEGRCDSCGGELYQRDDDKVETIRRRLDVYDEQTVPLKLYYERASLLRKVDALGSIESVSQSIQNIVASR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y15</accession>
    <name>RL10_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplJ</name>
        <name type="ordered locus">Gmet_0617</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514633.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y15"/>
    <dbReference type="SMR" id="Q39Y15"/>
    <dbReference type="STRING" id="269799.Gmet_0617"/>
    <dbReference type="EnsemblBacteria" id="ABB30859">
        <property type="protein sequence ID" value="ABB30859"/>
        <property type="gene ID" value="Gmet_0617"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0617"/>
    <dbReference type="eggNOG" id="COG0244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092227_0_0_7"/>
    <dbReference type="OMA" id="VRDQKQA"/>
    <dbReference type="OrthoDB" id="1470978at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05797">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00362">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022973">
        <property type="entry name" value="Ribosomal_L10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_L10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002363">
        <property type="entry name" value="Ribosomal_L10_eubac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_L10P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11560">
        <property type="entry name" value="PTHR11560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="SSF160369"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01109">
        <property type="entry name" value="RIBOSOMAL_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000234850" description="50S ribosomal protein L10">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00362"/>
        </source>
    </evidence>
    <sequence length="174" mass="18749" checksum="E490FFE7BD17743D" modified="2005-11-22" version="1">MNRENKQQQVAELHEKLKRAKAVFLADFRGMSVEQATTLRNELRAAAVEYKVAKNTLLELASKETDKESLSPHYAGPTAIAFSYDDPVAAAKVLSKFAKTQANTFKLKAAVLSGKQISVSDIQALADLPSREVLLAKLLGTINAPVANFVGVLAAVPGSFVRALNAIKIQKEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y70</accession>
    <name>Q39Y70_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512258.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0561"/>
    <dbReference type="EnsemblBacteria" id="ABB30804">
        <property type="protein sequence ID" value="ABB30804"/>
        <property type="gene ID" value="Gmet_0561"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0561"/>
    <dbReference type="eggNOG" id="COG1732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1459346_0_0_7"/>
    <dbReference type="OMA" id="DSRELYG"/>
    <dbReference type="OrthoDB" id="770506at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223297" evidence="1">
        <location>
            <begin position="23"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="186" mass="20124" checksum="C1248E33039573A7" modified="2005-11-22" version="1">MKKLFCCIVAVSILAVAQLSGACVGRTLHIGVSNTANERLLGEMISILITERTGTSVKVQVYRDSRELYGAVRKGEVNLLVETPDRALEVLGKQKEANGGNSRDLIKSGYRSTFNLAWLEPFGGSPQYAPVLTVETLSNYPALPKLLAKLSGALNNDAYARLLKSSDAGGKSRKAVRDFLKAKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YD1</accession>
    <name>Q39YD1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512196.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0500"/>
    <dbReference type="EnsemblBacteria" id="ABB30743">
        <property type="protein sequence ID" value="ABB30743"/>
        <property type="gene ID" value="Gmet_0500"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0500"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_7"/>
    <dbReference type="OMA" id="ERIFANI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="130"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="366" mass="40325" checksum="21F14CA5CC930C1F" modified="2005-11-22" version="1">MSGSGSTHPTLVVAADGKIIEANDAFTLLSGYRAEAVTGRLFHEVVLCADGAPGIASMETLSGVELRKASGARLSLLAVVSPMLGQNLAPYRYIVKLIECREIPEVAQTLAATESRLEVSERELQTFVSSVSHDLRSPVVSIKGFTGELRGLTENFMRQIGKAPDLSPESEALFTQYREEMLEAIGFVESSAKRVERLVNLLVVFSKLEGIPLNDQRVDMAGLFRSVLTSMRHRIGQKDCQISMEAVFPSLMIDPTVTERIFSNILDNAVKYLDPSRPGAITIKAGENDREVIFSIRDNGIGIAEYNRHKVFMFFRRATDLDIPGDGVGMPLARALLKRYRGRIWFESLEGTGTTFHVAFPKTLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YF4</accession>
    <name>Q39YF4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cobalt-precorrin-8X methylmutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cbiC</name>
        <name evidence="6" type="ordered locus">Gmet_0477</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobH/CbiC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513846.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0477"/>
    <dbReference type="EnsemblBacteria" id="ABB30720">
        <property type="protein sequence ID" value="ABB30720"/>
        <property type="gene ID" value="Gmet_0477"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0477"/>
    <dbReference type="eggNOG" id="COG2082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084703_1_1_7"/>
    <dbReference type="OMA" id="GAPIFCD"/>
    <dbReference type="OrthoDB" id="1812068at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016993">
        <property type="term" value="F:precorrin-8X methylmutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003722">
        <property type="entry name" value="Cbl_synth_CobH/CbiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036588">
        <property type="entry name" value="CobH/CbiC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02570">
        <property type="entry name" value="CbiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63965">
        <property type="entry name" value="SSF63965"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiC" evidence="5">
        <location>
            <begin position="9"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="214" mass="22718" checksum="0FD74F282533DCC7" modified="2005-11-22" version="1">MSVHLAPEEIEAESFRLIDEEVGTHHWGPAEWPVVRRAIHTSADFDYVRTMVFSPRAVARGVAALRQGRGIVTDTTMALSGIAKPRLKRFGLGAACFVADPEVAREAKALGITRSIVAMRKGAADGGNGIFVIGNAPTALFELLRLIREEGVRPALIVGLPVGFVGAAESKEALLALEDEFPDIPFITNRGRKGGSNVAAAVVNALLILAEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YF7</accession>
    <name>Q39YF7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt ABC transporter, membrane protein CbiQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cbiQ</name>
        <name evidence="7" type="ordered locus">Gmet_0474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CbiQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513843.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0474"/>
    <dbReference type="EnsemblBacteria" id="ABB30717">
        <property type="protein sequence ID" value="ABB30717"/>
        <property type="gene ID" value="Gmet_0474"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0474"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_5_0_7"/>
    <dbReference type="OMA" id="AWRYLFV"/>
    <dbReference type="OrthoDB" id="1499028at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="23"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="250" mass="26889" checksum="219124C35CD02F7D" modified="2005-11-22" version="1">MHRLSHPVSTPNPVTLLDPRVKLVSALALLVMVVSCTGFAFPLLAAALGLALCLWLGVPAQLILVRFAEPLFIAAVVLLLKTFFSGTEPLFSVHPFGLEIVAHRDGLAEGGAIAARIAGAVAVVAAVGFATPFTDLMAALAWLRVPQGLIDVALFAWRYLFVLFDDAQVVYAAQRNRLGYAGFRRGLRSFGMLAGALVIKAFDTSQTITTAMVQRGYDGNLPLLKHRPFRAEEATASVLFVAAMGMLRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YG9</accession>
    <name>Q39YG9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar protein FlbD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">flbD</name>
        <name evidence="1" type="ordered locus">Gmet_0462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513831.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0462"/>
    <dbReference type="DNASU" id="3738719"/>
    <dbReference type="EnsemblBacteria" id="ABB30705">
        <property type="protein sequence ID" value="ABB30705"/>
        <property type="gene ID" value="Gmet_0462"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0462"/>
    <dbReference type="eggNOG" id="COG1582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173020_0_0_7"/>
    <dbReference type="OMA" id="CTPDTVV"/>
    <dbReference type="OrthoDB" id="2007051at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009384">
        <property type="entry name" value="SwrD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39185">
        <property type="entry name" value="PTHR39185"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06289">
        <property type="entry name" value="FlbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="87" mass="9927" checksum="A3D4173FCE8D1A66" modified="2005-11-22" version="1">MIKLTRLDGSEFLVNPDLIEAVEETPDTHITLVNGKKYLVLEKAPAIVDKIVTFKALVLHRANPGKAKKYLFRKKMTIYRLCCPLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YH9</accession>
    <name>Q39YH9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513820.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0452"/>
    <dbReference type="EnsemblBacteria" id="ABB30695">
        <property type="protein sequence ID" value="ABB30695"/>
        <property type="gene ID" value="Gmet_0452"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0452"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068669_3_1_7"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="294" mass="33128" checksum="6CEFE1AB2C20605D" modified="2005-11-22" version="1">MVAETIKSFCGDRQTTVCRICGETLTETTVTSGQQPYETTWILCGACGSWSIGREPDIERLNAFYSDYSVHHKMAATNTDANDGKRYSDEWRETREREYRLSINDIGLELEQGKDLVDFGAYDGVFLDVCRATQPNMGKTTAVDYPREDTLHLAVRGHNFEPINEWLAGESLTDIVTLWDVYEHIADLPGLLTTLSRRVKSGGQVLIQTPRAHVHAQILGPQWHHFLPVQHLQLPSREGILRQFDRYGFTAVQVASFGANAPGSIIPQPYKQLFDTLAKLGDLGSTQLIRFVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YW6</accession>
    <name>Q39YW6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514025.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0313"/>
    <dbReference type="EnsemblBacteria" id="ABB30558">
        <property type="protein sequence ID" value="ABB30558"/>
        <property type="gene ID" value="Gmet_0313"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0313"/>
    <dbReference type="HOGENOM" id="CLU_1576254_0_0_7"/>
    <dbReference type="OrthoDB" id="2061599at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="169" mass="18383" checksum="E46782C717ABCE03" modified="2005-11-22" version="1">MKKHSTFAIFNPGFCTIRSAPPSSAECLKTKPEAVTENNRGKRQRGALDGQQTIGALLSHGGHENAHKGETAKDGKSWLLLKKKDRYATGEDILGENRSVFSGRTQEKAFKTAPGKGSGQKRRERIRLREALENPALKEAPAPPMPRDIRPMLATPAEAPSTTPIGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z12</accession>
    <name>Q39Z12_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA pseudouridine 65 synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">truC</name>
        <name evidence="2" type="ordered locus">Gmet_0267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513584.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0267"/>
    <dbReference type="EnsemblBacteria" id="ABB30512">
        <property type="protein sequence ID" value="ABB30512"/>
        <property type="gene ID" value="Gmet_0267"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0267"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_11_4_7"/>
    <dbReference type="OMA" id="DRHETQF"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140098">
        <property type="term" value="F:catalytic activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="9"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="270" mass="30096" checksum="EB42D5F0E266A429" modified="2005-11-22" version="1">MEILYRDEHLVAVHKPLGLLVHRSPIDRHETRFALQEVRDLLGRRVYPVHRLDKPTSGVLLFALDPAFARGLVGAFASGSVTKTYLAVVRGTMPEEGVIDHPLAEEPDRFEQGRGNAGERAPQSAVTGYRRLADVELPVAVGRYPTSRYSLVSLSPRTGRRHQLRRHLKHLFHPIVGDTKYGEGRHNRFFREELLTVRMLLHAVELTVPHPATGAPLTVCAPVEGAFAALLARFGWLSAVPSRWLGPQGKSMAGEEMQTRQRISPVLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z40</accession>
    <name>Q39Z40_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytosine/adenosine deaminase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0239</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513555.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0239"/>
    <dbReference type="EnsemblBacteria" id="ABB30484">
        <property type="protein sequence ID" value="ABB30484"/>
        <property type="gene ID" value="Gmet_0239"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0239"/>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_5_2_7"/>
    <dbReference type="OMA" id="LVVNWRP"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="23"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="186" mass="20121" checksum="CB0D178EF9BA53B5" modified="2005-11-22" version="1">MLHLSMPLPEWARTSVGNSGIFAGDAEKMAFAISLARSNVEEGTGGPFGAAIFNRESGELVSVGVNLVVAGMNSVLHAEMVAIMAAEAVLGTYTLAVRGRFELFSSCEPCAMCLGGILWSGVERLVCAAAADDARAIGFDEGPVYPESYCYLKERGIEIERGFMREEGKRVLELYRERGGILYNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z41</accession>
    <name>Q39Z41_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30483">
        <property type="protein sequence ID" value="ABB30483"/>
        <property type="gene ID" value="Gmet_0238"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0238"/>
    <dbReference type="eggNOG" id="ENOG502ZUAA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_185991_0_0_7"/>
    <dbReference type="OMA" id="AVEWGVG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="81" mass="8677" checksum="B041E80E2856041A" modified="2005-11-22" version="1">MTIKVGNIVSHPRGQEWGAGKVLEITSTLAMIQFSDGIKRKIAVSHFSTLEPAAPGSYLPPVEVPVVAKPSRAPRASKKKI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z69</accession>
    <name>ARLY_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate lyase</fullName>
            <shortName evidence="1">ASAL</shortName>
            <ecNumber evidence="1">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argH</name>
        <name type="ordered locus">Gmet_0209</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512798.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z69"/>
    <dbReference type="SMR" id="Q39Z69"/>
    <dbReference type="STRING" id="269799.Gmet_0209"/>
    <dbReference type="EnsemblBacteria" id="ABB30455">
        <property type="protein sequence ID" value="ABB30455"/>
        <property type="gene ID" value="Gmet_0209"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0209"/>
    <dbReference type="eggNOG" id="COG0165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027272_2_3_7"/>
    <dbReference type="OMA" id="KKNPDVF"/>
    <dbReference type="OrthoDB" id="751464at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00114"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="PTHR43814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000240732" description="Argininosuccinate lyase">
        <location>
            <begin position="1"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00006"/>
        </source>
    </evidence>
    <sequence length="458" mass="51048" checksum="3F0EA38DF1C4523A" modified="2005-11-22" version="1">MTHEKLWGGRFSEPTDKFVEEFTASIDFDKRLYHQDIRGSIAHARMLGKQGIIPMEDVEKITAGLQEILRQIQGGQFKFSVALEDIHMNIEARLSEKIGEAGKRLHTGRSRNDQVALDIRLYLRDEIVEVSAYLDLLVDSLISQAEKNLGVIMPGYTHLQTAQPILFSHHMMAYVEMFSRDKGRMEDCLRRMNVLPLGAGALAGTTFPIDREHVAEILDFPEVTRNSLDSVSDRDFALEFMAASSILMMHLSRFSEELILWSTSEFKFVDLSDSFCTGSSIMPQKKNPDVPELVRGKTGRVYGNLMALLTVMKALPLAYNKDMQEDKEPLFDTIDTVKGSLKIFADMVGEMRINTGNMRAAAAKGFSTATDVADYLVRKGMPFRDAHEVVGKTVAYCLSNGKDLPDLTLGEWQGFSDKIGEDIFGCITLEASVNARSATGGTALERVKAEIARVKAGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z80</accession>
    <name>RECA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein RecA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Recombinase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recA</name>
        <name type="ordered locus">Gmet_0198</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512787.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z80"/>
    <dbReference type="SMR" id="Q39Z80"/>
    <dbReference type="STRING" id="269799.Gmet_0198"/>
    <dbReference type="EnsemblBacteria" id="ABB30444">
        <property type="protein sequence ID" value="ABB30444"/>
        <property type="gene ID" value="Gmet_0198"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0198"/>
    <dbReference type="eggNOG" id="COG0468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040469_1_2_7"/>
    <dbReference type="OMA" id="DYGEQAL"/>
    <dbReference type="OrthoDB" id="1080436at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00983">
        <property type="entry name" value="recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00268">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013765">
        <property type="entry name" value="DNA_recomb/repair_RecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020584">
        <property type="entry name" value="DNA_recomb/repair_RecA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023400">
        <property type="entry name" value="RecA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45900">
        <property type="entry name" value="PTHR45900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00142">
        <property type="entry name" value="RECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54752">
        <property type="entry name" value="SSF54752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02012">
        <property type="entry name" value="tigrfam_recA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00321">
        <property type="entry name" value="RECA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_1000047925" description="Protein RecA">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00268"/>
        </source>
    </evidence>
    <sequence length="339" mass="36476" checksum="970DB3210F2E4E50" modified="2005-11-22" version="1">MTQEREKAIELALSQIEKQFGKGAIMRLGADEALPDIDAIPTGALSLDIALGVGGVPRGRVIEIYGPESSGKTTLALHIAAEAQKLGGIAAFVDAEHALDIGYARKLGVRTDDLLVSQPDTGEQALEIAEMLVRSGAVDVLVIDSVAALVPKAEIEGEMGDSHVGLQARLMSQALRKLTGIISKSNCCVIFINQIRMKIGVMFGSPETTTGGNALKFYASVRLDIRKIATLKQGDAVIGSRTKVKVVKNKVAPPFREVEFDIYYGEGISRLGDLLDLAVDRKIIDKSGAWFSYGSDRIGQGRENSRNFLKEHPEMVAEIEDKIYETAGIPRKGGKEEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZH3</accession>
    <name>Q39ZH3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514107.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0102"/>
    <dbReference type="EnsemblBacteria" id="ABB30351">
        <property type="protein sequence ID" value="ABB30351"/>
        <property type="gene ID" value="Gmet_0102"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0102"/>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336463_0_0_7"/>
    <dbReference type="OMA" id="ARYLSYE"/>
    <dbReference type="OrthoDB" id="1481641at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="184" mass="21530" checksum="164250DBF33BEA11" modified="2005-11-22" version="1">MGIPEDIAQFEQCLNELIIKYEQYFLGLEKREPLRLLETVDRLARKYVSVKIVNTMLNFKYNSLVAKLGSYRQYWNRILRLMEEGKYSRDRFRMAMHERPAQAAKNDASPSPSHDEADELYRQFIEARRSCNLPVETVTRDMVASAIEKQKPAIVAKYGTDRVEFRIVIENGVPKIKARPRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZQ7</accession>
    <name>Q39ZQ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein SlyX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">slyX</name>
        <name evidence="2" type="ordered locus">Gmet_0017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513782.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0017"/>
    <dbReference type="EnsemblBacteria" id="ABB30267">
        <property type="protein sequence ID" value="ABB30267"/>
        <property type="gene ID" value="Gmet_0017"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0017"/>
    <dbReference type="eggNOG" id="COG2900">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180796_5_2_7"/>
    <dbReference type="OMA" id="ELEIRYM"/>
    <dbReference type="OrthoDB" id="2039245at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007236">
        <property type="entry name" value="SlyX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36508">
        <property type="entry name" value="PTHR36508"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04102">
        <property type="entry name" value="SlyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="67" mass="7783" checksum="8107EE8FDC9A225D" modified="2005-11-22" version="1">MNNRITDLEIHVTHLSRTVHELNDVVYRQQQTIDRLEAELKGLREQALAAAPSLVRKPEDEEPPPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZR3</accession>
    <name>Q39ZR3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fgrK</name>
        <name evidence="8" type="ordered locus">Gmet_0011</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513776.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0011"/>
    <dbReference type="EnsemblBacteria" id="ABB30261">
        <property type="protein sequence ID" value="ABB30261"/>
        <property type="gene ID" value="Gmet_0011"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0011"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_7"/>
    <dbReference type="OMA" id="ELCMVEE"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="109"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="261"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="82"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="483" mass="54843" checksum="F86A8355860108B2" modified="2005-11-22" version="1">MKLPYHTMPFRIAAYYALCAGLWILLSDRLLGVAVRDPDLITSLETAKGWLFVAVTALLLHVVVRRFVDEVMRREELLRERNEELCMVEEELRQQLDESERAQQELRESEENYRLLFSSNPHPMCVFDLETLAFLEVNGSAIQHYGYSREEFLAMTIKDIRPPEDVPSLMAIVKRVDSGPDRVGVWRHRKKDGTIISVEITSHMIDFAGRRAKVILCNDVTERIRAKEEILRLNAELEQRVRQRTAELEQANREMESFSYSVSHDLRAPLRHIDGFSRVLLEDCGDQLNQEGKGYLTRICAAANRMGQLIDDLLQLASVSRSELQRRPVDFSNLARTIALELKQTDPEREVTFTIAGGVSAQGDPVLLRVVLENLLGNAWKYTGKNHRTAIEFGAVEGEEGRVYFVRDNGVGFDMTYVGKLFTPFQRLHAMDEFEGTGIGLATVRRVVERHGGRAWAEGTIGAGATFYFTLGESHRLAEGDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZS2</accession>
    <name>Q39ZS2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Beta sliding clamp</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">dnaN</name>
        <name evidence="14" type="ordered locus">Gmet_0002</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a ring-shaped head-to-tail homodimer around DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the beta sliding clamp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513721.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0002"/>
    <dbReference type="EnsemblBacteria" id="ABB30252">
        <property type="protein sequence ID" value="ABB30252"/>
        <property type="gene ID" value="Gmet_0002"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0002"/>
    <dbReference type="eggNOG" id="COG0592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038149_4_0_7"/>
    <dbReference type="OMA" id="YLIMPVR"/>
    <dbReference type="OrthoDB" id="1040142at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00140">
        <property type="entry name" value="beta_clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001001">
        <property type="entry name" value="DNA_polIII_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022635">
        <property type="entry name" value="DNA_polIII_beta_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022637">
        <property type="entry name" value="DNA_polIII_beta_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022634">
        <property type="entry name" value="DNA_polIII_beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30478">
        <property type="entry name" value="PTHR30478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00712">
        <property type="entry name" value="DNA_pol3_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02767">
        <property type="entry name" value="DNA_pol3_beta_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02768">
        <property type="entry name" value="DNA_pol3_beta_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000804">
        <property type="entry name" value="DNA_pol_III_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00480">
        <property type="entry name" value="POL3Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00663">
        <property type="entry name" value="dnan"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_beta" evidence="11">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_2" evidence="12">
        <location>
            <begin position="129"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol3_beta_3" evidence="13">
        <location>
            <begin position="253"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="373" mass="41526" checksum="8BDA1186B722DC10" modified="2005-11-22" version="1">MEFKIDKETFSRALQKIQGIVEKRNTMPILSNVLIEAHADRIELTATDLEVGMKSSYETTVTREGRITVSAKKLYEIVKELPEEAISFATKENDWVEIRCGKAHFSIVGLSPEEFPYFPKVNEESLIRIEGALLADMIEKTAYAICFDETKYNLNGTFVKATVEDDKPILRMVATDGHRLSIAEKEFHGAVGPEMAKGVIFPKKGIFELKKICEEATTEELALGFMDNSAVIKKGNTVVVMRLVDGEFPDYTRVVPVANDKIVTVARDPFLHSLRRMSILSSEKFKGIRMEINGEQMIISSSNPELGEASEELDAAYSGPPLSIRFNAKYLLDVLAVLNESEVALVLRDELSPAIVKPAAVDGFTAVIMPMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>J7LW68</accession>
    <name>J7LW68_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0223"/>
    <dbReference type="EnsemblBacteria" id="AFR42790">
        <property type="protein sequence ID" value="AFR42790"/>
        <property type="gene ID" value="Gmet_0223"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0223"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_7_7"/>
    <dbReference type="OMA" id="IGMASPM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFR42790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="426" mass="45111" checksum="060B226CE53E089C" modified="2012-10-31" version="1">MEKTPNRWGIAIICTLLMVCLGTVYAWSFFQKPFCDTHWTNSQVAWVFSLAICFLGLAAAAGGMMLPRIGPTKLALAGGALFGAGYLLAALALGMHSLPLLYIGYGVVGGTGLGLGYVTPVATVARWFPDRKGFATGMVVMGFGFGALLMSKVIAPLLLAQMGGDMVTVFAVMGVLFLLVTVPAATFVRYPPTGWVPPEYALPRDQAGSGPDDGGRGARACILSGEFALLWGIFFCNITAGLALIGFQSPLFQEICGEASPGLGKEALARYGATLIATSSLFNGVGRFFWGGLSDRIGRPETFRLILGSQFLAFVLLMRTDSPWHFALLVCYVLLCDGGGFGTMPAFVLDMFGARVMPAVYGAILTAWSAAGIAGPQLVALIKDRYPAELYPGRASVYSFAMGCGFLLVGFALSFLTRSRRGKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>J7M096</accession>
    <name>J7M096_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511503.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3604"/>
    <dbReference type="EnsemblBacteria" id="AFR42822">
        <property type="protein sequence ID" value="AFR42822"/>
        <property type="gene ID" value="Gmet_3604"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3604"/>
    <dbReference type="HOGENOM" id="CLU_2193193_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="108" mass="11730" checksum="5D6748D8305F4B3E" modified="2012-10-31" version="1">MGTFKRLAIGVIVLVLPLLMTACIGPRATVTVIAKPGDTVQLLHPGPKAAKEEFSHNEIVPVYRYTGLRKYGGYKEVGKVRITGYAGEHHLEGVVVEGNIQGNDFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEP5</accession>
    <name>J9JEP5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3639"/>
    <dbReference type="EnsemblBacteria" id="AFR42854">
        <property type="protein sequence ID" value="AFR42854"/>
        <property type="gene ID" value="Gmet_3639"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3639"/>
    <dbReference type="HOGENOM" id="CLU_2824976_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="66" mass="7346" checksum="46B0DD102B52CB2A" modified="2012-10-31" version="1">MKAVHLYLSAQPVKILTIFFDGFSVGFGSLIKIDTPCDRKSEMGAAGRIGLARESDEYKSCFKRFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PV1</accession>
    <name>Q39PV1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cbcS-1</name>
        <name evidence="2" type="ordered locus">Gmet_3518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513675.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3518"/>
    <dbReference type="EnsemblBacteria" id="ABB33723">
        <property type="protein sequence ID" value="ABB33723"/>
        <property type="gene ID" value="Gmet_3518"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3518"/>
    <dbReference type="eggNOG" id="ENOG503384B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143263_0_0_7"/>
    <dbReference type="OMA" id="KNHVWRP"/>
    <dbReference type="OrthoDB" id="806702at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome_C7" evidence="1">
        <location>
            <begin position="81"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="18213" checksum="27F669B0CC698791" modified="2005-11-22" version="1">MKSHVWRPLFVALGLVILILVARVFVVPADFGIGERGYMYGWHRKGNEEEWKKVTVKYKTKAYCKECHGEKVESIGRSPHGVLQCENCHGPALDHPKDPPTLTIDHSRKLCIRCHAKLDTPSSGRSKIRGIDPETHNPEAECSLCHDPHHPNLEELKRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PY7</accession>
    <name>Q39PY7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase of ISGme6, ISL3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0900</name>
        <name evidence="3" type="ordered locus">Gmet_3481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365741.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31142">
        <property type="protein sequence ID" value="ABB31142"/>
        <property type="gene ID" value="Gmet_0900"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33687">
        <property type="protein sequence ID" value="ABB33687"/>
        <property type="gene ID" value="Gmet_3481"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0900"/>
    <dbReference type="KEGG" id="gme:Gmet_3481"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041900_0_2_7"/>
    <dbReference type="OMA" id="DEDRWCR"/>
    <dbReference type="OrthoDB" id="1128314at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="158"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="417" mass="48990" checksum="7F02E7C9BE7B7F13" modified="2005-11-22" version="1">MLIKTVLNKFERFKSFIYGDCRLAKVGGSEALVIDIKARRNSKPECPECGKRGKTYDTQPARLFEYVPIWAFKVFFRYAPRRVLCPIHGVKVESLPWGYGKEQMTISYQVYLARWARRLSWKEVAEIFKTSWDSIFRAVQYAVDYGLANRNLDGVTEIGVDEIAVFKGHQYLTMVYQLNAGVRRLLWCGPQRRIRTLLRFFREFGKERSAKLKYVCSDMWAPYLKVIAKRAPNAVNILDRFHIMRKFNEAIDEVRRTEAKEFKAVKQENVLEKGRWLLLKRPENLSEKQTSRLGDLLKLNLSSIKAYLLREDFQQFWDYQRSDFAGKFLDDWVIRTMQTDLEPMKKVARMLRNHKPMILNWFKAKGRLSSGAVEGLNLKAKLTIRKAYGFRTIKCLQVALYHTLGDLPEPLCHHRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q03</accession>
    <name>Q39Q03_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF-C2</name>
        <name evidence="5" type="ordered locus">Gmet_3462</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513913.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3462"/>
    <dbReference type="EnsemblBacteria" id="ABB33671">
        <property type="protein sequence ID" value="ABB33671"/>
        <property type="gene ID" value="Gmet_3462"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3462"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="ASHNMAE"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="8"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="308" mass="33790" checksum="6C67D2ECE0158C88" modified="2005-11-22" version="1">MNGNGTAVEFGGLTRVFGDFTAVDHISLTVRKGEIFGFLGPNGAGKSTTIKMLCGLLTPTAGKGMVGGFDIMGEAEEIKKTIGYMSQKFSLYDDLTVEENINFFSGIYRVPREKKRERKEWVLEMAGIAGKRGALTRTLSGGFKQRLALGCAILHEPPIIFLDEPTSGVDPISRRNFWRLIYDMAREGKTIFVTTHYMDEAEYCDRLALIYRGRIIAEGMPGTLKERHMARDVLEIEVEGVVEALELLDSHGIDAAIFGSVLHATVENAADDIPRIREALAGGGIGAVRIEKIVPSLEDVFVTLIETS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q55</accession>
    <name>ATPG_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase gamma chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector gamma subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase gamma subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpG</name>
        <name type="ordered locus">Gmet_3407</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514214.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Q55"/>
    <dbReference type="SMR" id="Q39Q55"/>
    <dbReference type="STRING" id="269799.Gmet_3407"/>
    <dbReference type="PRIDE" id="Q39Q55"/>
    <dbReference type="EnsemblBacteria" id="ABB33619">
        <property type="protein sequence ID" value="ABB33619"/>
        <property type="gene ID" value="Gmet_3407"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3407"/>
    <dbReference type="eggNOG" id="COG0224">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050669_0_1_7"/>
    <dbReference type="OMA" id="MQITSAM"/>
    <dbReference type="OrthoDB" id="1701531at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042777">
        <property type="term" value="P:proton motive force-driven plasma membrane ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00815">
        <property type="entry name" value="ATP_synth_gamma_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="PTHR11693"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="SSF52943"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000053218" description="ATP synthase gamma chain">
        <location>
            <begin position="1"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00815"/>
        </source>
    </evidence>
    <sequence length="287" mass="31935" checksum="520E627EC8B1E00C" modified="2005-11-22" version="1">MASLKSIKKRIVSVKNTRQITKAMKMVSAAKLRRAQENVVAARPYAKKLGEVLDRLAKSQDGSSSPLLQKRISQKALLVVVTSDRGLCGGFNANICKAAERFIREKKAEFAEISVTTVGRKGFEFLKNRQKIHKNYGNVLSNLSYPTAALLAQEVVEGYVAEEYDEVYLLFNAFRSVMSQDITLQQLLPIVPEETAEEEYVPEYIYEPSKGELLDELLPKHIEVQVFKALLESVASEHGARMTAMDSASKNATEMIGKLTLQYNRARQAAITTELMEIISGAESIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q80</accession>
    <name>Q39Q80_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_3382</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512608.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3382"/>
    <dbReference type="EnsemblBacteria" id="ABB33594">
        <property type="protein sequence ID" value="ABB33594"/>
        <property type="gene ID" value="Gmet_3382"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3382"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_7"/>
    <dbReference type="OMA" id="TVIGNFR"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="252"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="470" mass="51890" checksum="9670DF0441B34E35" modified="2005-11-22" version="1">MFFRSIRFSLTLWYAVTLAVILVLFSSFIYLILQNQLTKEIDRELLTVAEAVASPTLEPFRRAGPSVFDQVLEDFIGTRLTGKFVQVLDGGGRITASSKGAEGLRTPLGKGASRRAWAGKVTYETKVSLDLYPVRTITYPIMDNGRLLQIVQVGTSMRAAAETLDKVLVVFAVSIPLALILWSVGGWFLAGRALKPVDFITRSAQKITAENLGLRLEVVNPQDEIGRLAITFNDTLERLEDAFRRVKQFTGDVSHELRTPLTILRGETEVGLRWAREPEEFRELFRSNLEEINRMSKIIEALLELSRAEEGGLKLERVPIELEDLLGELVQQSRLIDPEKGLKIAFSAVTPVTVTGDWLRLRQVFMNLLDNAVTYTPAGGEVSVVLDASGGFARVTVIDSGVGIPADDLPHIFERFYRVDKARNRADGGCGLGLSLVRTITEAHGGKIDVVSEVGKGSVFTVYLPLQGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QG4</accession>
    <name>Q39QG4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA--acetate/3-oxoacid coenzyme A transferase, subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atoA</name>
        <name evidence="3" type="ordered locus">Gmet_3297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit B family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512521.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3297"/>
    <dbReference type="EnsemblBacteria" id="ABB33510">
        <property type="protein sequence ID" value="ABB33510"/>
        <property type="gene ID" value="Gmet_3297"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3297"/>
    <dbReference type="eggNOG" id="COG2057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_4_1_7"/>
    <dbReference type="OMA" id="VAMMHTN"/>
    <dbReference type="OrthoDB" id="1380130at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="218" mass="22838" checksum="99A5DAC8DBBBAA89" modified="2005-11-22" version="1">MALTREQLAQRAAQEVEDGFYVNLGIGIPTMVANYIPPACHVVLQSENGLLGIGPSPREDEVDPELINAGKETITMIPGACIFSSSDSFAMIRGGHIDLAILGGMEVSDSGDLANWMIPGKMVKGMGGAMDLVHGAKKIVVVMEHCSKGGQSKILKQCTLPLTGKGVVNRIITDLAVMDVTGDGLILRELAPEVSVDDVVRATEASLAVPADVGTMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QP3</accession>
    <name>Q39QP3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512656.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3218"/>
    <dbReference type="EnsemblBacteria" id="ABB33431">
        <property type="protein sequence ID" value="ABB33431"/>
        <property type="gene ID" value="Gmet_3218"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3218"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="ANEIVIC"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="16877" checksum="BECE96B6838D1838" modified="2005-11-22" version="1">MTNRHILLVEDNPDDEVLTLRALRKHNIASEITVARDGVEALDFLFGTGTHGGRDTTTMPCLVLLDLKLPKVDGLEVLRRIRSDERTKLLPVVVFTSSNEEQDILECHTLGANSYIRKPVDFNHLSEALRLIGTYWLTMNLTPKLSNAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QS6</accession>
    <name>Q39QS6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3185</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512623.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3185"/>
    <dbReference type="EnsemblBacteria" id="ABB33398">
        <property type="protein sequence ID" value="ABB33398"/>
        <property type="gene ID" value="Gmet_3185"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3185"/>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074768_0_0_7"/>
    <dbReference type="OMA" id="KMEVPCC"/>
    <dbReference type="OrthoDB" id="1020023at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12837">
        <property type="entry name" value="Fer4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="4"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="237" mass="25156" checksum="15FAB53BFFAFE788" modified="2005-11-22" version="1">MIRKIVQIDEEKCNGCGLCVPACAEGAIKIVNGKAVLAADNLCDGLGACLGDCPQDAIRIIEREADEFDEAAVDEHLKGTGPQPHGHHAGGCPGSRAMAFAPSHPAGEQSAGGKIASRLRQWPVQLHLVPTTAPYFQDADLLIAADCVAFAHGDFHREFLEGKALVMGCPKLDDNNAYLQKLTELFRVSSIRSITVLRMEVPCCGGIVMAARQALTASGKNIPFREVTIGIQGDVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QT3</accession>
    <name>Q39QT3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mannose-1-phosphate guanylyltransferase and mannose-6-phosphate isomerase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_3178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366156.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3178"/>
    <dbReference type="EnsemblBacteria" id="ABB33391">
        <property type="protein sequence ID" value="ABB33391"/>
        <property type="gene ID" value="Gmet_3178"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3178"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017652_1_0_7"/>
    <dbReference type="OMA" id="NRPIMEH"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_I" evidence="5">
        <location>
            <begin position="386"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="6">
        <location>
            <begin position="535"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="7">
        <location>
            <begin position="651"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="807"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="836" mass="92882" checksum="BCEC6E7BDB79C10D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QT5</accession>
    <name>Q39QT5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">UDP-glucose--galactose-1-phosphate uridylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galT</name>
        <name evidence="10" type="ordered locus">Gmet_3176</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33389.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366155.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3176"/>
    <dbReference type="EnsemblBacteria" id="ABB33389">
        <property type="protein sequence ID" value="ABB33389"/>
        <property type="gene ID" value="Gmet_3176"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3176"/>
    <dbReference type="eggNOG" id="COG1085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029960_1_0_7"/>
    <dbReference type="OMA" id="DWVMIAS"/>
    <dbReference type="OrthoDB" id="1064872at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008108">
        <property type="term" value="F:UDP-glucose:hexose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00608">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001937">
        <property type="entry name" value="GalP_UDPtransf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005849">
        <property type="entry name" value="GalP_Utransf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01087">
        <property type="entry name" value="GalP_UDP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000808">
        <property type="entry name" value="GalT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00209">
        <property type="entry name" value="galT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="GalP_UDP_transf" evidence="9">
        <location>
            <begin position="2"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-UMP-histidine intermediate" evidence="7">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33389.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="341" mass="39008" checksum="385472D66D837FB8" modified="2012-10-31" version="2">MSELRWDPLKQHWVIIATDRGRRPRDFLVEPEPTEMTSCPFCYGNEDKTPGEVYVVRPVGGANATGWKVRVIPNRFPVLRIEGELNSRAYGIYDVMNGIGAHEIIIETPDHNRGLAELSPAEITEVLKAYRARFLDLRRDTRFRYMVLFKNHGRRAGATLSHSHSQLIAVPLIPPAAATELRVCREHYANKERCLFCDLLDFELQSGDRIVREFGNYVIMTPYASCFPFELRLYPKRHSHDFALSTDGELAELAVALKDMLGRLKSVLKDPPYNFILHTAPPPQPRLGKPEFWSSIEYDYHWHIELVPRLTPIAGFEWGTGFYINPTSPEDAATFLRGAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QX8</accession>
    <name>Q39QX8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0111 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514307.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3132"/>
    <dbReference type="EnsemblBacteria" id="ABB33346">
        <property type="protein sequence ID" value="ABB33346"/>
        <property type="gene ID" value="Gmet_3132"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3132"/>
    <dbReference type="eggNOG" id="COG1392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086031_0_1_7"/>
    <dbReference type="OMA" id="LFNGKYD"/>
    <dbReference type="OrthoDB" id="1837604at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018445">
        <property type="entry name" value="Put_Phosphate_transp_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01865">
        <property type="entry name" value="PhoU_div"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="205" mass="23276" checksum="9297D20E4F302134" modified="2005-11-22" version="1">MFGLIPKEEKFFALFKDMTANIIEGAKLLKDMIDNYDDPQGMQKRIKDVEHKGDHITHDIIQKLNKSFVTPLDREDIYALSAALDDILDLIDASSQRFIMYNVEKPTPEAKELAFIILKSCEAVAKAVAQLGGKFEHIAESCVEVNALENEADRVCREAISRLFDEEKDPIQLIKWKEIYETLERATDKCEDAANILESVVVKNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QZ3</accession>
    <name>Q39QZ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514292.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3117"/>
    <dbReference type="EnsemblBacteria" id="ABB33331">
        <property type="protein sequence ID" value="ABB33331"/>
        <property type="gene ID" value="Gmet_3117"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3117"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_758119_0_0_7"/>
    <dbReference type="OMA" id="FGEIANQ"/>
    <dbReference type="OrthoDB" id="1245015at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="246"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="188"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="365" mass="40216" checksum="17F0196262D97EDF" modified="2005-11-22" version="1">MDGFTNLTSIIDNALKQTAEDSGMLLGQELTIGEADIIATNRATYFCDLDEVCFVAEVTASGEYPGTFHLVFGLRDAICMSGFLLGIPSARINEKRRLAIMETDDADAFSEIINQAIGSFNTVFQPAFENKVHLKVVPPKKFVPETTEITDTEPIPDGEYLMFRARMEMPGLEMGNFDILMPRGLAELFDPPAEEPEPVPEDSGSDSEEGDEAAAAEEEFVATPVVAPVAEEGEAASAVVESCARRVLILEDDETDRQMVRELLETRGFELVEARLDADIREIFSQGGVRLVVLGIHNNDDRDMSLCIKIKAIAQGETLPIIMCAREWTRTAVLKAVRYGARDIILKPYQEDDVLAKVEKFLNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R11</accession>
    <name>Q39R11_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Flagellar motor switch protein FliN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">fliN</name>
        <name evidence="9" type="ordered locus">Gmet_3099</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FliN/MopA/SpaO family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514553.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3099"/>
    <dbReference type="EnsemblBacteria" id="ABB33313">
        <property type="protein sequence ID" value="ABB33313"/>
        <property type="gene ID" value="Gmet_3099"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3099"/>
    <dbReference type="eggNOG" id="COG1886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097058_4_1_7"/>
    <dbReference type="OMA" id="MTEIIKT"/>
    <dbReference type="OrthoDB" id="1875967at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012826">
        <property type="entry name" value="FliN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001172">
        <property type="entry name" value="FliN_T3SS_HrcQb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00956">
        <property type="entry name" value="FLGMOTORFLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02480">
        <property type="entry name" value="fliN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="5" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="8">
        <location>
            <begin position="22"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="101" mass="11181" checksum="B510C850FC1B4038" modified="2005-11-22" version="1">MSDLDNENLKDGELDTKNLNFILDIPLQLTVELGRTKILVKDVLQLNQGAVVELTKLAGEPLDVFVNSKLVARGEAVVVNEKFGIRLVDIVSPNERVEKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R38</accession>
    <name>Q39R38_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Threonine and serine dehydratase and deaminase, catabolic</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tdcB</name>
        <name evidence="7" type="ordered locus">Gmet_3072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-serine = NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-threonine = 2-oxobutanoate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:22108"/>
            <dbReference type="ChEBI" id="CHEBI:16763"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.3.1.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513631.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3072"/>
    <dbReference type="EnsemblBacteria" id="ABB33286">
        <property type="protein sequence ID" value="ABB33286"/>
        <property type="gene ID" value="Gmet_3072"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3072"/>
    <dbReference type="eggNOG" id="COG1171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021152_4_1_7"/>
    <dbReference type="OMA" id="LIHPFDH"/>
    <dbReference type="OrthoDB" id="1876944at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:L-threonine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04886">
        <property type="entry name" value="ACT_ThrD-II-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044561">
        <property type="entry name" value="ACT_ThrD-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005789">
        <property type="entry name" value="Thr_deHydtase_catblc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01127">
        <property type="entry name" value="ilvA_1Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="6">
        <location>
            <begin position="17"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="402" mass="43055" checksum="D7AF49C974C35F38" modified="2005-11-22" version="1">MLPYTLIQEASDRLKKRVRRTELIHSHHFSERFGFPLLFKCENLQRTGAFKIRGALNFMTSQPREALTKGVITASAGNHAQGVAFSADLLGAQATVFMPESTPPQKVQATKEYGADVVLTGRNFDEAYAAAVQAQKETGALFVHPFDDPLVMAGQGTIGLEILDELPDVSAILVPIGGGGLIAGIATAVKETHPHVRIIGIESKAAPSMHFSLKKGKIVEAPLTVTLADGIAVKKVGRNTFPIIRELVDDVVLVEEEEIALAIVGLLERTKLLVEGAGAVTLAALLNGKAGKLPGKTVCVLSGGNIDVKTISTVVERGLVAAGRYLKLQVVLDDIPGSLAGLATEVAAVRANIFLINHERRSLDLPLGKTEVLLELETRGYEHIQEIIGHLGRRGYEVDVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R60</accession>
    <name>Q39R60_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3049</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513609.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3049"/>
    <dbReference type="EnsemblBacteria" id="ABB33264">
        <property type="protein sequence ID" value="ABB33264"/>
        <property type="gene ID" value="Gmet_3049"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3049"/>
    <dbReference type="eggNOG" id="ENOG50309MK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059693_0_0_7"/>
    <dbReference type="OMA" id="FEIARAW"/>
    <dbReference type="OrthoDB" id="430920at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009492">
        <property type="entry name" value="TniQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06527">
        <property type="entry name" value="TniQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="397" mass="46611" checksum="594FC17BE3ADA5B0" modified="2005-11-22" version="1">MTKLVYKVRRRGAYAHYNFPLKLRPQKDELLSSWLIRLALRHRTMPMTFTNLYMPETKNMLWSVDMDLQSAPDFLSTLATKSGAPLEALQAMTLEGYEGYLFEKAFTKTGGTQFILPLRMRGRQNTSHGLRFCPVCLREDEQPYFRRKWRLSFSTACVRHKCFLRDRCPACLAPLTVYRRPSVVDFPNCDKCGFPLKSAEVEPIARGSYGLKAIKRMYAILGCGFIMLGEVPVYSFLFFIIIHQLWKAAHFWDKTDGFLHHEVMKDRVDDLTWELKPTVLDQIRLKEQYLFFSGLMHLFEDYPHRLMDYCRRNRFGKTELTRDLRIVPYWYSKIVDRFDHTFWPLSCDEVSSVLEYMKSKDMDVQLDRVKSLIGRGIDFRKRTDIAKVFGAAGSRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RB9</accession>
    <name>Q39RB9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33205.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366132.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2990"/>
    <dbReference type="EnsemblBacteria" id="ABB33205">
        <property type="protein sequence ID" value="ABB33205"/>
        <property type="gene ID" value="Gmet_2990"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2990"/>
    <dbReference type="HOGENOM" id="CLU_1935022_0_0_7"/>
    <dbReference type="OMA" id="TCLSCHN"/>
    <dbReference type="OrthoDB" id="1978006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223443" evidence="1">
        <location>
            <begin position="25"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33205.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="133" mass="14310" checksum="5AC9DC434B19E851" modified="2012-10-31" version="2">MNRITSAGLAVAVVLSTGSASARAETVDHYGAMVDRRASFEECVACHDGTIAKDVAYCRENCSIRTPHPIMRRYPPPGREAAYRPVEFLREAGIELADGMVVCISCHNLGNPPPFHLAVDPATGSLCLSCHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RG0</accession>
    <name>Q39RG0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrolase, putative, cyclic phosphodiesterase-like domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512882.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2946"/>
    <dbReference type="EnsemblBacteria" id="ABB33164">
        <property type="protein sequence ID" value="ABB33164"/>
        <property type="gene ID" value="Gmet_2946"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2946"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_731069_0_0_7"/>
    <dbReference type="OMA" id="PFEPHVT"/>
    <dbReference type="OrthoDB" id="671579at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="SSF55144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="378" mass="42915" checksum="809D021E807BF5DF" modified="2005-11-22" version="1">MTERRFSVFLVPASDDRRWAQGVIAELAARYDTPPFEPHVTVYGGSCVDDGELEPVRQVLAEAAAEGGPITLRVSGLGVTEEYFKTLFVSFEEEPRLRRLHEGVKGAVARDSGYVLMPHLSLLYADMPLAEKEMAARTVALDREEIRFDEVKIVTPDSITGWSDVRRWQTLFRVRLGEPVIRAVLFDYGGVLAEEGFREGLFEIARRQGLDPIAVHGAGMEAVYGSGYVLGKGSETAFWRRMREQAGLRGSARELSALILDRFVLRPGMLELVRALRAKGYITAIVSDQTDWLEWLDRRDGFFREFDRVFNSYRLGKGKRDPSLFDDVARELGIEPRQALFVDDMLANVVRAESRGVRGIVFEDEARFRRELRRYVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RH1</accession>
    <name>Q39RH1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thiamine-phosphate synthase</fullName>
            <shortName evidence="8">TP synthase</shortName>
            <shortName evidence="8">TPS</shortName>
            <ecNumber evidence="8">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="8">TMP pyrophosphorylase</shortName>
            <shortName evidence="8">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">thiE</name>
        <name evidence="12" type="synonym">tenI</name>
        <name evidence="12" type="ordered locus">Gmet_2935</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 8 9">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8 9">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 8 10">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512871.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2935"/>
    <dbReference type="EnsemblBacteria" id="ABB33153">
        <property type="protein sequence ID" value="ABB33153"/>
        <property type="gene ID" value="Gmet_2935"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2935"/>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018272_3_4_7"/>
    <dbReference type="OMA" id="VSAICHA"/>
    <dbReference type="OrthoDB" id="1558094at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00141"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="11">
        <location>
            <begin position="8"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="8">
        <location>
            <begin position="38"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="8">
        <location>
            <begin position="186"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="213" mass="22401" checksum="E17325CD5B0F037E" modified="2005-11-22" version="1">MSKVDFSLYLITDRRQTTGRDLPAVVEEALAGGVRAVQLREKDLSSRELLELARVMRELTGRYGAKLIINDRVDIALATDADGVHLGEASIPADAARRILGAHRLIGVSCHNREGALAAEKSGADFITFGPVYPTPSKAAYGAPVGVERLAEAAALLTIPVFALGGIKGDNIPEVLATGAAGVALISAVIAAVNPNEEARAILTLLEQGRRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RL9</accession>
    <name>Q39RL9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2887</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512823.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2887"/>
    <dbReference type="EnsemblBacteria" id="ABB33105">
        <property type="protein sequence ID" value="ABB33105"/>
        <property type="gene ID" value="Gmet_2887"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2887"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169332_0_0_7"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="237" mass="26704" checksum="5010F20A9C036749" modified="2005-11-22" version="1">MLNALKNRLRVWYDPEMKAIARIIREMNSKGGDDLVVTECNKVFVDRLRVFPIALKMDFWEHHFELEGFSDFPEIGGDILDFGCGSGHLDVYLARRGFTVTGVDLSPVGIAIASFIRENEAADVKKRLLFFVADVTADLPPRQFDAAWSAHVFEHIKNPGPVLAGLKNWIKPGGSLLISVPFGRAYDDPGHVNHFYSEADLQHYLGGHISVERIKIYRDHQVIRALCKNDGDGKNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RN2</accession>
    <name>Q39RN2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514605.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2874"/>
    <dbReference type="EnsemblBacteria" id="ABB33092">
        <property type="protein sequence ID" value="ABB33092"/>
        <property type="gene ID" value="Gmet_2874"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2874"/>
    <dbReference type="eggNOG" id="ENOG5033DSE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166570_0_0_7"/>
    <dbReference type="OMA" id="YVHISIP"/>
    <dbReference type="OrthoDB" id="2017617at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="85" mass="9863" checksum="E467A35C87A07DC8" modified="2005-11-22" version="1">MHPYVIIFGLILLALIINIPCGFLRQGYEKFTFGWYFYVHISIPFIIYLRVKSGFSWKFIPLTLGGAMVGQIIGGMIHRRRQRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RQ3</accession>
    <name>Q39RQ3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Branched-chain-amino-acid transaminase</fullName>
            <ecNumber evidence="10">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">ilvE</name>
        <name evidence="15" type="ordered locus">Gmet_2853</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts on leucine, isoleucine and valine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-isoleucine = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + L-leucine = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2-oxoglutarate + L-valine = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 4/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514563.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2853"/>
    <dbReference type="EnsemblBacteria" id="ABB33071">
        <property type="protein sequence ID" value="ABB33071"/>
        <property type="gene ID" value="Gmet_2853"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2853"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031922_0_2_7"/>
    <dbReference type="OMA" id="LTEVFAC"/>
    <dbReference type="OrthoDB" id="1275805at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00058"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00073"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00062"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="PTHR11825"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 15" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="14">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00003109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00005072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00013053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB33071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="357" mass="39352" checksum="E6E2BBDAA114FA2C" modified="2005-11-22" version="1">MEIRIAPLPEGRKKPKYTDESQLGFGKLFTDRMFMVEWKIGQGWVDARIEPYAPFVLDPACSVLHYAQEIFEGLKAYKWADGTITLFRPEMNARRFNHSADRLCMPEVPEELFLDGIEKLVALERDWIPSSEGTSLYIRPTMIGVDPVLGVKPADHYYFYVILSPVGAYYSAGFNPIKIMVEDQYVRSVPGGTGEAKTGGNYACSLKAGLEAKKKGYDQVLWLDGVHRRYIEEVGAMNMLFAYGKTIVTASLTGTILNGVTRDSTLKLAASLGYTIEERLIDVNELMADIRAGKVTEAFGSGTAAVISPVGVLAYKDEVCTVGNGGVGPITQQLYDTLTGIQTGKVPDTFGWTRKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RU0</accession>
    <name>Q39RU0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT-like repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366107.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2816"/>
    <dbReference type="EnsemblBacteria" id="ABB33034">
        <property type="protein sequence ID" value="ABB33034"/>
        <property type="gene ID" value="Gmet_2816"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2816"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_384437_0_0_7"/>
    <dbReference type="OMA" id="HPLDRRN"/>
    <dbReference type="OrthoDB" id="946324at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="720" mass="78979" checksum="9ABED7623FA1353C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RX9</accession>
    <name>Q39RX9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511684.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2777"/>
    <dbReference type="DNASU" id="3739280"/>
    <dbReference type="EnsemblBacteria" id="ABB32995">
        <property type="protein sequence ID" value="ABB32995"/>
        <property type="gene ID" value="Gmet_2777"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2777"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168237_0_0_7"/>
    <dbReference type="OMA" id="PDWVCGE"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="78" mass="8490" checksum="4A9D2F79831AD390" modified="2005-11-22" version="1">MECLKCGTCCIAPDITTLGKPVGERCRHLGEAGLCTAYDVRPAVCRGYRPDETCLLVAAPTLEERVGKYLRLFGLDVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S36</accession>
    <name>Q39S36_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc protease TldD, putative modulator of DNA gyrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tldD</name>
        <name evidence="6" type="ordered locus">Gmet_2720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511740.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2720"/>
    <dbReference type="EnsemblBacteria" id="ABB32938">
        <property type="protein sequence ID" value="ABB32938"/>
        <property type="gene ID" value="Gmet_2720"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2720"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_1_0_7"/>
    <dbReference type="OMA" id="MLYADYV"/>
    <dbReference type="OrthoDB" id="806701at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025502">
        <property type="entry name" value="TldD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004919">
        <property type="entry name" value="TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="3">
        <location>
            <begin position="22"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="5">
        <location>
            <begin position="111"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="4">
        <location>
            <begin position="227"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="460" mass="48410" checksum="A4950ED77C1230B6" modified="2005-11-22" version="1">MLDGMNLSVILRRALAGGGEFADIYYEEGSSTSIICEDGKIEKVLAGTDRGVGIRVISDLRTAYAYTNEVTETALLALAETVSRAVKGEQFGRAIDMRTKLVGPGFPIEIPPDNVPLQDKVALVNRGDAAARGFDKRIRQVTAVYRDGAVKTQIANSLGDFTEALRTGTLFLTQVVAADGDVIQTGYEPVGRFMGHEIFRERSPEEVALAAARRAVMMLGARKAPGGLMPVVLSSEAGGTMVHEAIGHGLEADLAGSGMSVYTGKVGEQVASPLVTVIDDATIPNARGSFSFDDEGTPAQRTVLVENGILKGYLYDRLSAMKDGCASTGNGRREGYHAKPIVRMTNTLIAPGESSPEEIVRGVEKGLFVRKMGGGQVNTVNGDFVFEVSEGYLIENGVVTEPVRGATLTGNGPDVLKKIVKVGSDLGFGIGTCGKDGQGVPVSDAQPTLLIEEITVGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S54</accession>
    <name>Q39S54_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphate transport system permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pstC</name>
        <name evidence="11" type="ordered locus">Gmet_2702</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2702"/>
    <dbReference type="EnsemblBacteria" id="ABB32920">
        <property type="protein sequence ID" value="ABB32920"/>
        <property type="gene ID" value="Gmet_2702"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2702"/>
    <dbReference type="eggNOG" id="COG0573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_1_3_7"/>
    <dbReference type="OMA" id="ETMALYM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011864">
        <property type="entry name" value="Phosphate_PstC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02138">
        <property type="entry name" value="phosphate_pstC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="78"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="319" mass="33778" checksum="96F9A44BFCB18385" modified="2005-11-22" version="1">MTNETPSPPIAPSKRLNADLVFKAVTAAFAFSILLILALMTLEMVKESLPAIKAFGWKFAGSSDWDAVQGIFGALPYIWGSVVSSLLALALATPLSVGTALFVTEIAPKRFGGAVAALVELLAAIPSVIYGLWGILVMAPWLQQTVQPFLSDHLGFLPFFQGAPYGVSMLAAVFILMIMVVPIITSITKEVLLAVPQSQREAAIALGATRWEMIRMAVLPYGRSGILGAVILGLGRAIGETMAVTMVIGNTPQISLSLLSPAYTMPSVIANEFAETTSKLHASALMEIGLLLLVVTLVINVMARLLLWGMTRQAAGGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S74</accession>
    <name>Q39S74_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2682</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511778.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2682"/>
    <dbReference type="EnsemblBacteria" id="ABB32900">
        <property type="protein sequence ID" value="ABB32900"/>
        <property type="gene ID" value="Gmet_2682"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2682"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_9_1_7"/>
    <dbReference type="OMA" id="SYHYQMG"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223044" evidence="2">
        <location>
            <begin position="20"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="247" mass="28074" checksum="8EAF21BCC73FC892" modified="2005-11-22" version="1">MKRLLVLIVMALFSLTACAVTDASRKQASYHFQMGLSYLGENDATRALIELAEAEKLTPDDPALLNSLGLAYFYKKRYDLAELKYRRAIELKPDYSEARNNLGVNYLEMQRWDDAVAQFTLVLADLFFINHEDARINLGLAYLGKGDYPKSLDILRQAVATSPQNIVARVGLGRVYFAMDRNDLAIQEFTKAVELNKNYQNGYYYLALAHLKGKDYVSAADAFREAIRIAPDSEKGRLSREYLESMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SA4</accession>
    <name>Q39SA4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511809.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2652"/>
    <dbReference type="DNASU" id="3740172"/>
    <dbReference type="EnsemblBacteria" id="ABB32870">
        <property type="protein sequence ID" value="ABB32870"/>
        <property type="gene ID" value="Gmet_2652"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2652"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801139_0_0_7"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00595">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223221" evidence="1">
        <location>
            <begin position="25"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="2">
        <location>
            <begin position="118"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="220"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="346" mass="37507" checksum="567CE8DF70EB2AE9" modified="2005-11-22" version="1">MKKTLPQLVIMSVLCLLAALPALAQEEIPAAAKERFKAGLALIEKADKSADFLAALAEFEAAAALAPTWPDSHYNLAQLAAESDKPAKAIKEYRAYLALKPDAADRGAVEAEMARMKELIALKRKVGLPGVTFAAMADGIWVLQVLPGAGIEKTGLRKGHQIVGVGGKPLAGNKLEDLFKAIEANNITDTMSRGSSERMYSRMTRDTKTQGPVVVLNVKQSRQQEKPFLILCKKEMFRSKIIEIEEDEFEDEVLKAPLPVAVTFWGDSCEPCKEFVPVLEAESAKYAGKVKFVNINVDGNRKLADQLAVKEVPALMVYKGGSAVATATGKLPREKVAEMLQDAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SA5</accession>
    <name>Q39SA5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2651</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511811.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2651"/>
    <dbReference type="EnsemblBacteria" id="ABB32869">
        <property type="protein sequence ID" value="ABB32869"/>
        <property type="gene ID" value="Gmet_2651"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2651"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_3_2_7"/>
    <dbReference type="OMA" id="LGDYPAG"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="50"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="290" mass="31636" checksum="12A752AD92544582" modified="2005-11-22" version="1">MNRRDFLQFGLRGIVVAGLGKGFYNTTSEQVEIVRTSVKIRNLPAALQGLKIGLLTDLHASFVVSSETIRSAGRLLMAEKPDLIVMTGDYISGSTRFLSGSVGQFKKEYLSKCIDALSGLKAPLGIYGVLGNHDFWSGPESVKAICEAFTRQMGMVWLRNSSVEIRRGRGSLHLLGVDDYWEPSCSLAAACKGVDTDGIKILLSHNPDINDEIFLLRERIDLVLSGHTHGGQVVVPFLGQPVMPSKFGQKYRAGLVRDGDRQTYISRGVGCLLAPIRLNCPPEATVLTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SB8</accession>
    <name>Q39SB8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511824.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2637"/>
    <dbReference type="EnsemblBacteria" id="ABB32856">
        <property type="protein sequence ID" value="ABB32856"/>
        <property type="gene ID" value="Gmet_2637"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2637"/>
    <dbReference type="eggNOG" id="COG3305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113251_2_0_7"/>
    <dbReference type="OMA" id="VEAYGLW"/>
    <dbReference type="OrthoDB" id="1920116at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021125">
        <property type="entry name" value="DUF2127"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09900">
        <property type="entry name" value="DUF2127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="159" mass="17264" checksum="8FE3D974D7881726" modified="2005-11-22" version="1">MTSPKRHPKAALHTVALFEATKGALVIAAGLGLLALIHRDVQALAEEIVRHLHLNPASRIPRIFLEAAGKADGGRLQLLALGAFGYASVRFAEAWGLWRGRPWAEWLGIVSGGIYLPLEVYELFISVTPVKLGTFLVNVAVVAVLARERLIACRSTRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SZ9</accession>
    <name>Q39SZ9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable lipid II flippase MurJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mviN</name>
        <name evidence="8" type="synonym">murJ</name>
        <name evidence="10" type="ordered locus">Gmet_2400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.</text>
    </comment>
    <comment type="pathway">
        <text evidence="8">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the MurJ/MviN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512500.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2400"/>
    <dbReference type="EnsemblBacteria" id="ABB32625">
        <property type="protein sequence ID" value="ABB32625"/>
        <property type="gene ID" value="Gmet_2400"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2400"/>
    <dbReference type="eggNOG" id="COG0728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006797_5_3_7"/>
    <dbReference type="OMA" id="IFFVAFK"/>
    <dbReference type="OrthoDB" id="749401at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015648">
        <property type="term" value="F:lipid-linked peptidoglycan transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13123">
        <property type="entry name" value="MATE_MurJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02078">
        <property type="entry name" value="MurJ_MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004268">
        <property type="entry name" value="MurJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03023">
        <property type="entry name" value="MurJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002869">
        <property type="entry name" value="MviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01806">
        <property type="entry name" value="VIRFACTRMVIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01695">
        <property type="entry name" value="murJ_mviN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0133">Cell shape</keyword>
    <keyword evidence="8 9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8 9" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR002869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="521" mass="56523" checksum="AB10D77C6DF9109D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T17</accession>
    <name>Q39T17_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase, HDc domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514759.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2382"/>
    <dbReference type="EnsemblBacteria" id="ABB32607">
        <property type="protein sequence ID" value="ABB32607"/>
        <property type="gene ID" value="Gmet_2382"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2382"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087303_0_0_7"/>
    <dbReference type="OMA" id="WVFDLNF"/>
    <dbReference type="OrthoDB" id="1331839at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="262" mass="29723" checksum="9EAD305F45500907" modified="2005-11-22" version="1">MDTSSLAGLHRWFADYCRTFHNDNEEHNRNIRLKEEHTAKVCAVMEILADSLALSPEDRRIAVAVALFHDIGRFEQYRRFRTFKDSSSVNHAELGGRVLAEGKVLAGLPEEEQRLIIGAVGLHNVFRIPAMLGDRQRLFLRLIRDADKLDIWRVFIEFYGQPAEERASAVSLGFPDIPECTPAVLDTLLRGEMVDLATLRTLSDFKLLQLSWVFDLNFPRSRELVRERGYVELIADTLSRTKCVERAIGVVRAALCARGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TD4</accession>
    <name>Q39TD4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Electron transfer flavoprotein-associated cytochrome b and CCG domain pair iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_2264</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366020.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2264"/>
    <dbReference type="EnsemblBacteria" id="ABB32490">
        <property type="protein sequence ID" value="ABB32490"/>
        <property type="gene ID" value="Gmet_2264"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2264"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_7"/>
    <dbReference type="OMA" id="MEGAFPG"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="11">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="661" mass="73150" checksum="A305A19EAE09F857" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TG2</accession>
    <name>Q39TG2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc-dependent alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2235</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365990.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2235"/>
    <dbReference type="EnsemblBacteria" id="ABB32462">
        <property type="protein sequence ID" value="ABB32462"/>
        <property type="gene ID" value="Gmet_2235"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2235"/>
    <dbReference type="eggNOG" id="COG1063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_11_0_7"/>
    <dbReference type="OMA" id="ETWYAMS"/>
    <dbReference type="OrthoDB" id="972769at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="PKS_ER" evidence="3">
        <location>
            <begin position="10"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="340" mass="36116" checksum="B6E9C820753B3324" modified="2005-11-22" version="1">MRAAVFHQIGKPLAIESLNDPIPLDGEVIVNVKACGICGTDIHATADKEMRLADGTVLGHEFAGEIVEVGPQVAVGWAQGDRLCTLPYIGCGHCLACLTGMPWQCKLKKVIGIQTAGGFAEYARVHVNEAVRLPVSVSWQEGALVEPLAIGLHAVRLSRGVAGKSVLVTGAGPIGLAVALWCRFFGARQVVVSEFDPERSKMALAMGATHAVDAKADVGAQYQEITGELPELIFECVGIPGLIAQCVDRAAFGAEIVVVGFCMRPDTFVPALAMLKEITVKFSIGNNKSDFQFIVDMLSSGRISVKPMITAAVSLDDLPKTFESLRTPGEHCKVVVEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-02-10" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TG3</accession>
    <name>Q39TG3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365989.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2234"/>
    <dbReference type="EnsemblBacteria" id="ABB32461">
        <property type="protein sequence ID" value="ABB32461"/>
        <property type="gene ID" value="Gmet_2234"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2234"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_8_3_7"/>
    <dbReference type="OMA" id="GCLMTFA"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="PTHR21660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="52"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="144" mass="16106" checksum="7FFB51200BADC58A" modified="2005-11-22" version="1">MTQSDPRLAEYRKWEGVDPWEEQSGPYYFQKEENGHYRCATITGRHSMNSEGRMHGGALMTFADYSLFVFARDCLQGITAVTVSITVDFIGGGGEGQFLESTGEVVHETGTLIFARGKIFHDEQVLLAFSGVLKKMNPRVPTYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TH0</accession>
    <name>Q39TH0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Molybdopterin-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2227</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365982.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2227"/>
    <dbReference type="EnsemblBacteria" id="ABB32454">
        <property type="protein sequence ID" value="ABB32454"/>
        <property type="gene ID" value="Gmet_2227"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2227"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_7"/>
    <dbReference type="OMA" id="HIWEKTR"/>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018818">
        <property type="term" value="F:acetylene hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02781">
        <property type="entry name" value="MopB_CT_Acetylene-hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034660">
        <property type="entry name" value="DinB/YfiT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037949">
        <property type="entry name" value="MopB_CT_Acetylene-hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="891" mass="98789" checksum="264BD946EB83E9C9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TJ3</accession>
    <name>Q39TJ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2204</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365960.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2204"/>
    <dbReference type="EnsemblBacteria" id="ABB32431">
        <property type="protein sequence ID" value="ABB32431"/>
        <property type="gene ID" value="Gmet_2204"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2204"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_7"/>
    <dbReference type="OMA" id="CADVILA"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="263" mass="29135" checksum="95ED346496CCD712" modified="2005-11-22" version="1">MKYTVFKVERKKNYGIITFNRPDKFNAANAQIFKELAAAVRELDADKKVGCIVLTGQTFKHPKKGTDYPVFSAGADVEQFATVGKVEAGFDFIKLCFEPFKAIELAETPIIAAVNGAAFGFGFEISGCCDMVFAAKSAKFALKEINHGAIPAWCITRGLEKYGKNVAAYLCFSAKELDADEAQRLGIVVDVYEDNELLPRCEELAERIAEKSHVAKTFIKTLLNRKAVEGYQEAERFMPTVFATQYMQGAFARFLGGETKNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TQ8</accession>
    <name>Q39TQ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxybenzoyl-CoA reductase maturation factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcmU</name>
        <name evidence="3" type="ordered locus">Gmet_2137</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513068.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2137"/>
    <dbReference type="DNASU" id="3740368"/>
    <dbReference type="EnsemblBacteria" id="ABB32366">
        <property type="protein sequence ID" value="ABB32366"/>
        <property type="gene ID" value="Gmet_2137"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2137"/>
    <dbReference type="eggNOG" id="COG1975">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041115_4_0_7"/>
    <dbReference type="OMA" id="YCIVMTH"/>
    <dbReference type="OrthoDB" id="1879870at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003777">
        <property type="entry name" value="XdhC_CoxI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027051">
        <property type="entry name" value="XdhC_Rossmann_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13478">
        <property type="entry name" value="XdhC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02625">
        <property type="entry name" value="XdhC_CoxI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XdhC_CoxI" evidence="1">
        <location>
            <begin position="12"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="XdhC_C" evidence="2">
        <location>
            <begin position="105"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="253" mass="28149" checksum="F09B8E918B5B542D" modified="2005-11-22" version="1">MWDWIGKLDELRRSNQLAVLVTVTKSSGSTPRKHGAKMIVLPDGTFYGTVGGGTPEYYALEDARACFETMQSTTSSVPLKQRGEFPACGGTMEFYMEVINDNPVLHLFGAGHIGQSLCQILDGTPFRIHLIDEREEWINAPNLPGSVIRHQRHYSDFIEKAIWCDKRTFVAIQTFSGTLDQQVLEEVLPNPTRYVGMIGSKAKWAKVRSNLEEKGLDLSAVRCPIGHDNGGNSPREIAISIASQLLSTYYGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TT3</accession>
    <name>Q39TT3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylphosphate carboxylase, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2112</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513093.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2112"/>
    <dbReference type="EnsemblBacteria" id="ABB32341">
        <property type="protein sequence ID" value="ABB32341"/>
        <property type="gene ID" value="Gmet_2112"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2112"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_3_7"/>
    <dbReference type="OMA" id="PEGILKC"/>
    <dbReference type="OrthoDB" id="1484726at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00413">
        <property type="entry name" value="HADHALOGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="239" mass="25012" checksum="3C3A72890FD88A54" modified="2005-11-22" version="1">MAFEGHSTFGTEAGPGAELCCSLAVRAVLFDLDGTLVDSVGAYIEVARVAAEPFGFEVTEEQVRLALSSGGSFWKGIVPEDRSDGAAILKAISANAAREWPRILREHGKLFDGVLETLDALKGLGILLGIVSGARPEVLELLRPNGVLERFDAVVLGKDVSKSKPDPEGILKCLDHLSVAPADALYVGDAPIDIFASRAAGVRVVSVLTGAGDSASLSMHAPDRLIPSHTVLPAIVTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TV8</accession>
    <name>Q39TV8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Benzoyl-CoA reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bamB-1</name>
        <name evidence="9" type="ordered locus">Gmet_2087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12 13" key="3">
        <citation type="journal article" date="2015" name="Nat. Chem. Biol." volume="11" first="586" last="591">
            <title>Structural basis of enzymatic benzene ring reduction.</title>
            <authorList>
                <person name="Weinert T."/>
                <person name="Huwiler S.G."/>
                <person name="Kung J.W."/>
                <person name="Weidenweber S."/>
                <person name="Hellwig P."/>
                <person name="Stark H.J."/>
                <person name="Biskup T."/>
                <person name="Weber S."/>
                <person name="Cotelesage J.J."/>
                <person name="George G.N."/>
                <person name="Ermler U."/>
                <person name="Boll M."/>
            </authorList>
            <dbReference type="PubMed" id="26120796"/>
            <dbReference type="DOI" id="10.1038/nchembio.1849"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH IRON-SULFUR (4FE-4S); MOLYBDOPTERIN AND ZINC</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514579.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="4Z3W">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.21 A"/>
        <property type="chains" value="A/B/C/D=1-653"/>
    </dbReference>
    <dbReference type="PDB" id="4Z3X">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A/B/C/D=1-653"/>
    </dbReference>
    <dbReference type="PDB" id="4Z3Y">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.36 A"/>
        <property type="chains" value="A/B/C/D=1-653"/>
    </dbReference>
    <dbReference type="PDB" id="4Z3Z">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="A/B/C/D=1-653"/>
    </dbReference>
    <dbReference type="PDB" id="4Z40">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="A/B/C/D=1-653"/>
    </dbReference>
    <dbReference type="PDBsum" id="4Z3W"/>
    <dbReference type="PDBsum" id="4Z3X"/>
    <dbReference type="PDBsum" id="4Z3Y"/>
    <dbReference type="PDBsum" id="4Z3Z"/>
    <dbReference type="PDBsum" id="4Z40"/>
    <dbReference type="SMR" id="Q39TV8"/>
    <dbReference type="DIP" id="DIP-61695N"/>
    <dbReference type="IntAct" id="Q39TV8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2087"/>
    <dbReference type="EnsemblBacteria" id="ABB32316">
        <property type="protein sequence ID" value="ABB32316"/>
        <property type="gene ID" value="Gmet_2087"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2087"/>
    <dbReference type="eggNOG" id="COG2414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_7"/>
    <dbReference type="OMA" id="HDEKWHT"/>
    <dbReference type="OrthoDB" id="332680at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 11 12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 11 12" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AFOR_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 14 15">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14 15">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="529"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="533"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="534"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="535"/>
        </location>
        <ligand>
            <name>Molybdopterin</name>
            <dbReference type="ChEBI" id="CHEBI:44074"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="4Z3W"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="4Z3X"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="4Z3Y"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="4Z3Z"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="4Z40"/>
        </source>
    </evidence>
    <sequence length="653" mass="73803" checksum="1BA0EE80CDF4678C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U38</accession>
    <name>Q39U38_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenylyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2007</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365900.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2007"/>
    <dbReference type="DNASU" id="3739879"/>
    <dbReference type="EnsemblBacteria" id="ABB32236">
        <property type="protein sequence ID" value="ABB32236"/>
        <property type="gene ID" value="Gmet_2007"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2007"/>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035301_5_2_7"/>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="487" mass="55677" checksum="E1A8EA997420713D" modified="2005-11-22" version="1">MQVYPLIMNKLVMPAASRFTDLKIWDEYKVMLKSERLSLEQLRQMQLTKLQTIVRHAYENVPFYRQRFDSIGLHPEDIKSIEDIERIPPTTKDDIMANFPEGITAGGMDRNRWKYVASSGTTRKIMGIHDFRKSTLNWAAGIRAHRLAGNHRMGMKWMEIPPHMCTTICGINDGPKGEKLSTKKLVSLVKEGDFGGAGRHVYEGLYSMRHDLYKRVTLPSFGPEGTNIPESDIVSYLDSIRSYQPHLLEGLPLYLYTFAKYILDKGISAPRVGVIKPFGGSLTPYMKQIIATAFGCEVYDTYGCSELGFMAADCPKHEGVHLFMDLYHVEVRHGDRAAAPGELGKFYVTDLENRAMPWIRYEIGDVGRYFEDDHGCGRRGIRLEVEGRVQDTLVNSQGRFFTSDEVFDFFHRREEIDNFQLTEKSAGRYELLCVPVEGKEVDREGIARDFREFFDTEANVKAYAVKTIKAEDGGKFRFIKAKGHDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U49</accession>
    <name>Q39U49_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512954.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1996"/>
    <dbReference type="EnsemblBacteria" id="ABB32225">
        <property type="protein sequence ID" value="ABB32225"/>
        <property type="gene ID" value="Gmet_1996"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1996"/>
    <dbReference type="eggNOG" id="ENOG5033G8P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_393675_0_0_7"/>
    <dbReference type="OMA" id="TAHEWWI"/>
    <dbReference type="OrthoDB" id="81534at68525"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="704" mass="78050" checksum="55168FBD71A2B93F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U90</accession>
    <name>Q39U90_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate mutase</fullName>
            <ecNumber evidence="1">5.4.99.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1955</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EC" id="5.4.99.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511889.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1955"/>
    <dbReference type="EnsemblBacteria" id="ABB32184">
        <property type="protein sequence ID" value="ABB32184"/>
        <property type="gene ID" value="Gmet_1955"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1955"/>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131518_3_1_7"/>
    <dbReference type="OMA" id="WRKKIDA"/>
    <dbReference type="OrthoDB" id="1980002at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="98" mass="11537" checksum="340902A0651264B4" modified="2005-11-22" version="1">MTIDELRQEIDRMDSELLRIFNRRASLALEIGLIKKERGLPVYDPKREKLIFERMKADNPGPLDDGAIVRLFERVIDESRRLERIMTHPEETTGKEES</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UB1</accession>
    <name>DXS1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-deoxy-D-xylulose-5-phosphate synthase 1</fullName>
            <ecNumber evidence="1">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-deoxyxylulose-5-phosphate synthase 1</fullName>
            <shortName evidence="1">DXP synthase 1</shortName>
            <shortName evidence="1">DXPS 1</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dxs1</name>
        <name type="ordered locus">Gmet_1934</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="1">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511909.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UB1"/>
    <dbReference type="SMR" id="Q39UB1"/>
    <dbReference type="STRING" id="269799.Gmet_1934"/>
    <dbReference type="EnsemblBacteria" id="ABB32163">
        <property type="protein sequence ID" value="ABB32163"/>
        <property type="gene ID" value="Gmet_1934"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1934"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_7"/>
    <dbReference type="OMA" id="FAPQGMF"/>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000256422" description="1-deoxy-D-xylulose-5-phosphate synthase 1">
        <location>
            <begin position="1"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <sequence length="625" mass="67363" checksum="B50A22A25BC0434C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UB7</accession>
    <name>Q39UB7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511915.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1928"/>
    <dbReference type="EnsemblBacteria" id="ABB32157">
        <property type="protein sequence ID" value="ABB32157"/>
        <property type="gene ID" value="Gmet_1928"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1928"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1592999_0_0_7"/>
    <dbReference type="OMA" id="MEKETHL"/>
    <dbReference type="OrthoDB" id="1611727at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="10"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="165" mass="19457" checksum="A9C651E93450DF0A" modified="2005-11-22" version="1">MFEEIDVQDAIKKSLQTEKNAMNFYQLGATRMKNKDAIRVFELLAKEEREHAGHFYKIYKGIDIPDFDEFMDAPPDQESTWMAAMTKTVNSDFTEQKALELAMHKEKKLEHTLRETAGKIKDENVRAIFELNARETHNHYEMIESEYARIMAMVHESDMDIYVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UH0</accession>
    <name>Q39UH0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dITP/XTP pyrophosphatase</fullName>
            <ecNumber evidence="7">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="7">NTPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rdgB</name>
        <name evidence="9" type="ordered locus">Gmet_1875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + ITP = diphosphate + H(+) + IMP</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>H2O + XTP = diphosphate + H(+) + XMP</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 8">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511970.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1875"/>
    <dbReference type="EnsemblBacteria" id="ABB32104">
        <property type="protein sequence ID" value="ABB32104"/>
        <property type="gene ID" value="Gmet_1875"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1875"/>
    <dbReference type="eggNOG" id="COG0127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082080_0_2_7"/>
    <dbReference type="OMA" id="DCFADDT"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:nucleoside-triphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009146">
        <property type="term" value="P:purine nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01405">
        <property type="entry name" value="Non_canon_purine_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020922">
        <property type="entry name" value="dITP/XTP_pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="Ham1p-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="PTHR11067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="SSF52972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00042">
        <property type="entry name" value="TIGR00042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="153"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="181"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="196" mass="20824" checksum="527BC2FC7E36EC94" modified="2005-11-22" version="1">MTDLIVATRNKGKLLEIGKILEGVHCRIYSLADFPDLPEIEEDGVTFEQNAIKKASAIAQLTGLPALADDSGLVVDALGGRPGVFSARYAGTGATDETNNAKLLEELRGTPPERRGAAFHCVIALCLPDGSCTTFSGELRGSILEVPQGGGGFGYDPLFFVEEEGSSLAELPLERKNRLSHRGKALELLKGKLSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UM0</accession>
    <name>Q39UM0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylacetyl-CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">paaK-2</name>
        <name evidence="4" type="ordered locus">Gmet_1825</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20956"/>
            <dbReference type="ChEBI" id="CHEBI:18401"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57390"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylacetyl-CoA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512020.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1825"/>
    <dbReference type="EnsemblBacteria" id="ABB32054">
        <property type="protein sequence ID" value="ABB32054"/>
        <property type="gene ID" value="Gmet_1825"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1825"/>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035301_1_1_7"/>
    <dbReference type="OMA" id="GVAPHFQ"/>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="UniPathway" id="UPA00930"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05913">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011880">
        <property type="entry name" value="PA_CoA_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006444">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="81"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="3">
        <location>
            <begin position="336"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="435" mass="48626" checksum="71CE1CBEF8EAB65F" modified="2005-11-22" version="1">MSYYNEEFETLPRQALEALQLKRLQATVARVCTSVPFYRQSFDRAGITPDSVKSLADLQRLPFTLKQNMRDSYPYGLFAAPMEEIVRIHASSGTTGKPTVVGYTRKDIDTWSELMARSYAAAGVHRGDIIHNSYGYGLFTGGLGAHYGAEKLGASVIPMSGGNTKKQILIMKDFGSTVLTCTPSYSLFMSEAAREEGVDFRELKLRVGIFGAEPWSEAMRSEIEEKLNLCAIDIYGLSEIMGPGVAIECCEAKKGLHIWEDHFIPEIINPETGEVLPEGERGELVITTITKEGIPLIRYRTRDITSLTYEPCACGRTHARLTRMTGRSDDMLIIRGVNVFPSQIESILMGIEGVEPHYVLIVDRKDNLDSLEVQVEVDERLFSDEIKVLQSLSQRVEKEIKDILGISCRVRLVEPQTITRSEGKAKRVIDNRKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UN3</accession>
    <name>Q39UN3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Menaquinol oxidoreductase complex ACIII, menaquinol-binding membrane protein subunit ActC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">actC</name>
        <name evidence="8" type="ordered locus">Gmet_1812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512034.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1812"/>
    <dbReference type="EnsemblBacteria" id="ABB32041">
        <property type="protein sequence ID" value="ABB32041"/>
        <property type="gene ID" value="Gmet_1812"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1812"/>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021295_1_0_7"/>
    <dbReference type="OMA" id="WWVGIGH"/>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="456" mass="51624" checksum="B263F8D6108BB002" modified="2005-11-22" version="1">MSEPTLPAAKNSSQLNDEMLSSLRTPTWSWYALALFLGAVVAWGLYAFGYMLTTDMSCTGLNRPVMWGVYIVNFVFWIGLSHSGTMVSAILRLSRANWRRPILRAAEAMTVFTVAVGGLFPLIHLGRNWVFFYLIPYPNQRGLWPNFRSALLWDATAIFTYIIGSSLFLYLGMLPDLAVARDRSSGWRFKLYSVLAMGWRGTAREWAIFHQASTLMAALIIPVAVSVHSIVAWDFAVTVIPGWHSTIFPPYFVIGAIHSGIAAVITLMIIIRRVFHLEDYLTPLHFDNMGKLLLVIALLWSYAYFVEVQTTWYAHEPIEWEVFSFMADKYAFLLLLMIFANSVLPIVALCFKRLRRSIGVMLVVSVLINVGMFIERFLIIVPSLSHKNMPFVWGTYRPTWVELSVTAGAFAGFALMYTLFAKCFPMVSVTDVRELEAQKSVVTLGRTRLQSIAEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UT8</accession>
    <name>Q39UT8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NADPH-dependent glutamate synthase, iron-sulfur cluster-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1755</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513349.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1755"/>
    <dbReference type="EnsemblBacteria" id="ABB31986">
        <property type="protein sequence ID" value="ABB31986"/>
        <property type="gene ID" value="Gmet_1755"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1755"/>
    <dbReference type="eggNOG" id="COG1142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_3_1_7"/>
    <dbReference type="OMA" id="CITEHSQ"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="149" mass="16599" checksum="79D8630F971301CD" modified="2005-11-22" version="1">MKRIYMIEDVCIGCHLCEVACITEHSQSKNPVKAFLHEEYRPISRCTVEEWDGGVVSFSTTCRHCDEPDCLRACISGAIQKDDKGVVRIDTEQCVGCWSCVMACPYGAVQRNLTKKKANKCDLCPDRTSPACVDACPNRALVYKEGSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UT9</accession>
    <name>Q39UT9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADPH-dependent glutamate synthase, NADPH oxidoreductase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513350.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1754"/>
    <dbReference type="EnsemblBacteria" id="ABB31985">
        <property type="protein sequence ID" value="ABB31985"/>
        <property type="gene ID" value="Gmet_1754"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1754"/>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_4_4_7"/>
    <dbReference type="OMA" id="IHHFWTF"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041575">
        <property type="entry name" value="Rubredoxin_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18267">
        <property type="entry name" value="Rubredoxin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="4">
        <location>
            <begin position="2"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin_C" evidence="5">
        <location>
            <begin position="321"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="436" mass="46598" checksum="814C88025D874137" modified="2005-11-22" version="1">MNYVIIGNSVAAVGAIRGIRSIDQQGNITVISRERHVAYGRPLISYLLGGLITEKRMAYLPEDFYEKNRVNLLLNAEVVGVDTDNRKVTIAGGDVIVYDKLLVATGGDPFVPPIEGMAGKDRIFTFTTWDDAAKLKGIADDIEKVVVIGGGLIGLKAAEGLHLIDKKITIVELADRILSAAFDRPAGRVVAKKMKANGIDVITEDTVVRIEGDGAAITGVTLKSGDFIPCDTVVVAIGVRPAAGFLKGSGVEVNRGIVVDDLMETNVKGVFAAGDVAEAKDFFSGVKNPMPIWPDAYIQGDIAGVTMAGGSKGYQGGIAMNSIELFKVSTISMGITNPVEPKEYEILTYQDLENYQYRKIVLKDGILAGAVLVGAVDRAGIFAGLIRDRIEVSSFKDHLLTPDFGFVNLPREIRSTLFAPVGKVTGAYEQARAVGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UU0</accession>
    <name>Q39UU0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADPH-dependent glutamate synthase, glutamine amidotransferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513351.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1753"/>
    <dbReference type="EnsemblBacteria" id="ABB31984">
        <property type="protein sequence ID" value="ABB31984"/>
        <property type="gene ID" value="Gmet_1753"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1753"/>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061941_0_0_7"/>
    <dbReference type="OMA" id="FKGVGFP"/>
    <dbReference type="OrthoDB" id="447435at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012375">
        <property type="entry name" value="Glu_synth_lsu_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018774">
        <property type="entry name" value="GOGAT_lg_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="2">
        <location>
            <begin position="18"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="1">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR018774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="373" mass="41935" checksum="F29497DEC7DE3A1C" modified="2005-11-22" version="1">MTRELKPTHYFQKDISNCGLTGFISTAGNLVEGSVIIKSIALMHDRGNGLGGGFAAYGIYPEFKDFYAFHLMYESGMAQQLTEEYLEQHFYIEHHEEIPTRRTPAIANPPAFKRYFVKPLQTAEYNEAIEFQNMTDEDVIVRHVMGINNGIEGAFVVSSGKNMGAFKGVGYPEEIANFFRLEEYKGYIWTAHNRFPTNTPGWWGGAHPFTLLDWSIVHNGEISSYGINKRYLEMYGYLCTMLTDTEVVAYTLDLLIRKHGLTPELASLAMASPFWDIIDALPEDERQLLTAIRQCYGSALLNGPFAILFASNEGLIGLNDRVKLRPLVCATKDDFVYMASEEAAIREICPKPDKVWAPRGGEPVIAKMQPGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UW4</accession>
    <name>Q39UW4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513374.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1729"/>
    <dbReference type="EnsemblBacteria" id="ABB31960">
        <property type="protein sequence ID" value="ABB31960"/>
        <property type="gene ID" value="Gmet_1729"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1729"/>
    <dbReference type="HOGENOM" id="CLU_2716693_0_0_7"/>
    <dbReference type="OMA" id="HEMDEFN"/>
    <dbReference type="OrthoDB" id="2178497at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="74" mass="8250" checksum="73F8ED0485FEA6BB" modified="2005-11-22" version="1">MRDSDQLPRYYLGTALQAMEKAYALNHDARVGQNISQAIAALHQLMHQTAASHVANDNKAPYDPYEVNEHNSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UY7</accession>
    <name>Q39UY7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response receiver-modulated diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514148.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1706"/>
    <dbReference type="EnsemblBacteria" id="ABB31937">
        <property type="protein sequence ID" value="ABB31937"/>
        <property type="gene ID" value="Gmet_1706"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1706"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_28_7"/>
    <dbReference type="OMA" id="NDYFVYP"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="180"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="324" mass="36331" checksum="3757D24747BCF079" modified="2005-11-22" version="1">MKILYIDDKAEIRTLLGRYLKSWGYDALGAPNGESGWNLIQEHRPSIVITDWIMPDLEGPALCRRIRGAGFPEYTYIIMLTARRDDVVVGMEAGADDFIGKPFNKEELKVRIKAAERIVTLERELALTNLGLQEKNRRLEESEEQLRQMAHFDKLTGLPNRLLFFERLERAVVESKRSESNFGLLFVDLDAFKAVNDNHGHKTGDELLVMAGQRMDGCVRASDTVARMGGDEFCIIVRGVKSFDGPVTVAEKIISALSRPFDISGITCRIGASVGISVYPHDGDSVELLMTHADNAMYEAKRGGKNSWRRWKPDSPDTDEGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V46</accession>
    <name>Q39V46_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipoprotein cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1647</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511417.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1647"/>
    <dbReference type="EnsemblBacteria" id="ABB31878">
        <property type="protein sequence ID" value="ABB31878"/>
        <property type="gene ID" value="Gmet_1647"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1647"/>
    <dbReference type="eggNOG" id="COG1858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_521599_0_0_7"/>
    <dbReference type="OMA" id="MPLAGIW"/>
    <dbReference type="OrthoDB" id="52724at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223310" evidence="5">
        <location>
            <begin position="25"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="321"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="522" mass="56155" checksum="5467D98611F45AB9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-07-24" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V51</accession>
    <name>PANB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-methyl-2-oxobutanoate hydroxymethyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ketopantoate hydroxymethyltransferase</fullName>
            <shortName evidence="1">KPHMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">panB</name>
        <name type="ordered locus">Gmet_1642</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + 3-methyl-2-oxobutanoate + H2O = (6S)-5,6,7,8-tetrahydrofolate + 2-dehydropantoate</text>
            <dbReference type="Rhea" id="RHEA:11824"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodecamer; pentamer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PanB family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511422.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V51"/>
    <dbReference type="SMR" id="Q39V51"/>
    <dbReference type="STRING" id="269799.Gmet_1642"/>
    <dbReference type="EnsemblBacteria" id="ABB31873">
        <property type="protein sequence ID" value="ABB31873"/>
        <property type="gene ID" value="Gmet_1642"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1642"/>
    <dbReference type="eggNOG" id="COG0413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036645_1_0_7"/>
    <dbReference type="OMA" id="VLVWTDM"/>
    <dbReference type="OrthoDB" id="916845at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00003"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003864">
        <property type="term" value="F:3-methyl-2-oxobutanoate hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06557">
        <property type="entry name" value="KPHMT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00156">
        <property type="entry name" value="PanB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003700">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20881">
        <property type="entry name" value="PTHR20881"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02548">
        <property type="entry name" value="Pantoate_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000388">
        <property type="entry name" value="Pantoate_hydroxy_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00222">
        <property type="entry name" value="panB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000297275" description="3-methyl-2-oxobutanoate hydroxymethyltransferase">
        <location>
            <begin position="1"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="46"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>3-methyl-2-oxobutanoate</name>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00156"/>
        </source>
    </evidence>
    <sequence length="267" mass="29081" checksum="09C27901A9553028" modified="2005-11-22" version="1">MNRKKTIIDIQKMKAAGEKITVLTSYDYPFTRVMDECGIDMILIGDSVGVVFSGYDNTLPVTMDEMIYHTRAVVRARPKALVVADMPFLSYQTDLRDARLNAGRLVKDGGAEAVKLEGGSHVADTIRAIVDMDIPVMAHIGLTPQSIHRMGGYKVQGKKEEQSQRLLDDAKAIEEAGAFAVVLEGIPLKLAEKITEELSIPTIGIGAGPHCDGQVLVIHDILGLCEKYSPKFVKRYGDANALITSAVSSYIAEVKKGEFPDEGHSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V74</accession>
    <name>Q39V74_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing ligase RtcB</fullName>
            <ecNumber evidence="4">6.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rtcB</name>
        <name evidence="5" type="ordered locus">Gmet_1619</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3 4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3 4">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RtcB family.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511445.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1619"/>
    <dbReference type="EnsemblBacteria" id="ABB31850">
        <property type="protein sequence ID" value="ABB31850"/>
        <property type="gene ID" value="Gmet_1619"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1619"/>
    <dbReference type="eggNOG" id="COG1690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022279_0_1_7"/>
    <dbReference type="OMA" id="QTRGVEC"/>
    <dbReference type="OrthoDB" id="1384936at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008452">
        <property type="term" value="F:RNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001233">
        <property type="entry name" value="RtcB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036025">
        <property type="entry name" value="RtcB-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11118">
        <property type="entry name" value="PTHR11118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01139">
        <property type="entry name" value="RtcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103365">
        <property type="entry name" value="SSF103365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01288">
        <property type="entry name" value="UPF0027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 4" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="1">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="334"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="383"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="408"/>
            <end position="411"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>GMP</name>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601233-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU371113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="485" mass="53568" checksum="DE5A08689157CE4C" modified="2005-11-22" version="1">MPAPSALKRITDTTWELPVSYKPGMLVPARIFATEKLITAMDAGVFDQVSNVACLPGIQKYAFCMPDGHWGYGFPIGGLAAMDPETGVISPGGIGFDINCGMRLVLTNLTEEEVKPRLRELVDALFYRVPAGVGSHGFVSLSHDEFCTVAEQGSRWCLKRGFAWPEDLEMTEEGGCFPGADASKISHKAIDRGYNQIGTLGSGNHYLEIQVARPENIYNEELARAFGITIPNQVVIMFHCGSRGFGHQVATDYLQLFLSVMERKYGITVNDRELACAPFRSREGQDYFAAMKCAVNMAFANRQVILHRIREVFSDNFGRDPADLGMEMVYDVAHNTAKLETHMVDGRRRELLIHRKGATRAFGPGMEGLPERYRETGQPVIIGGSMETGSYLLAGEPGGSETFFTTAHGSGRTMSRHQAKKMVRGQKLQRDMEERGIYVRTASWGGLAEESGRAYKDIDDVAEATERAHLSRRVVRLLPIGNVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VH6</accession>
    <name>Q39VH6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511553.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1514"/>
    <dbReference type="EnsemblBacteria" id="ABB31748">
        <property type="protein sequence ID" value="ABB31748"/>
        <property type="gene ID" value="Gmet_1514"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1514"/>
    <dbReference type="HOGENOM" id="CLU_670411_0_0_7"/>
    <dbReference type="OMA" id="FQLGWGK"/>
    <dbReference type="OrthoDB" id="710577at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223345" evidence="1">
        <location>
            <begin position="24"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="414" mass="45523" checksum="9D142ADB7213B1B8" modified="2005-11-22" version="1">MNGYPFRLCMILFVSLFSSPAVAGEFSGYAEAKGFVYPERARGQSPSVDGWGTLFNKWEEKLGEARLTASLRGEWLSTDDQGVRLLDPADRHFRRPPFSVQDFWLRLPLSPEIDLQMGRFQLGWGKTDGYSPADAFLPRDLTDPYADEKLPLWALRLSGQKGDVRYEAVGCPVTTPWRLPVLGSRNAPINGEIPRGVSLREMDSSPPVLGFGAIRLLATFGQWDVGGWVRAGIRPAPILEFRTDQAVETSGGIEIPVERRYAEEEGIGIELSRVVGAWVIRGEVAGLFSRNDHLGNAAIGSLSAEKAFGDGTLLMTLAGNAIDPPVDEILLFDRAILPALITAWTRTEEWGEWKTVWSVGLKHGDGLVKAELSYNITDVWKLTMGGEAPYGSGAGGFGALDAARRLRMAIRRSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VH7</accession>
    <name>Q39VH7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor helix-turn-helix transcriptional regulator, LuxR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1513</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511554.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1513"/>
    <dbReference type="EnsemblBacteria" id="ABB31747">
        <property type="protein sequence ID" value="ABB31747"/>
        <property type="gene ID" value="Gmet_1513"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1513"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072786_3_1_7"/>
    <dbReference type="OMA" id="PFFWTKT"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06170">
        <property type="entry name" value="LuxR_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005143">
        <property type="entry name" value="TF_LuxR_autoind-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036693">
        <property type="entry name" value="TF_LuxR_autoind-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000792">
        <property type="entry name" value="Tscrpt_reg_LuxR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03472">
        <property type="entry name" value="Autoind_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00196">
        <property type="entry name" value="GerE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00038">
        <property type="entry name" value="HTHLUXR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00421">
        <property type="entry name" value="HTH_LUXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75516">
        <property type="entry name" value="SSF75516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50043">
        <property type="entry name" value="HTH_LUXR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH luxR-type" evidence="2">
        <location>
            <begin position="176"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="246" mass="27505" checksum="7F1F443C8819BD19" modified="2005-11-22" version="1">MEWLSRREAVRLLELIDASRSCADMERLKRLFHSLNDLLSFDMAVCGTARFDGAGTMNAQQIINISYPEEWLSLYAEHDFAAVDPVVRAHIADFSAKPWSEAYLKWGRPQPFLSLAEDFGIRKGYSFGVLSSNDRTASIFSLCVSEKYPVHTPQILDILAPYFHEALRRTVQTDLPSACLATLTPREIEVISWLANGKNYWEISVILGISERTVKFHTSTIVQKLGAANRSHAVAIAISTGLISLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VI3</accession>
    <name>Q39VI3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase, beta-lactamase superfamily lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1507"/>
    <dbReference type="EnsemblBacteria" id="ABB31741">
        <property type="protein sequence ID" value="ABB31741"/>
        <property type="gene ID" value="Gmet_1507"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1507"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_463625_0_0_7"/>
    <dbReference type="OMA" id="DFDCQVG"/>
    <dbReference type="OrthoDB" id="537440at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223539" evidence="1">
        <location>
            <begin position="19"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="45"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="595" mass="65308" checksum="66DD40E8802068FA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VI4</accession>
    <name>Q39VI4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365838.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1506"/>
    <dbReference type="EnsemblBacteria" id="ABB31740">
        <property type="protein sequence ID" value="ABB31740"/>
        <property type="gene ID" value="Gmet_1506"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1506"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007251_1_0_7"/>
    <dbReference type="OMA" id="YDEAYIH"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="508"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="576"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="729" mass="79064" checksum="1B5FE8A34F6D55B7" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VR2</accession>
    <name>Q39VR2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphoglycerate mutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1428</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511640.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1428"/>
    <dbReference type="EnsemblBacteria" id="ABB31662">
        <property type="protein sequence ID" value="ABB31662"/>
        <property type="gene ID" value="Gmet_1428"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1428"/>
    <dbReference type="eggNOG" id="COG3635">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034906_2_0_7"/>
    <dbReference type="OMA" id="IAFRCNF"/>
    <dbReference type="OrthoDB" id="1293048at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16011">
        <property type="entry name" value="iPGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023665">
        <property type="entry name" value="ApgAM_prokaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004456">
        <property type="entry name" value="Pglycerate_mutase_ApgM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31209">
        <property type="entry name" value="PTHR31209"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10143">
        <property type="entry name" value="PhosphMutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006392">
        <property type="entry name" value="IPGAM_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00306">
        <property type="entry name" value="apgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02535">
        <property type="entry name" value="hyp_Hser_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="6">
        <location>
            <begin position="1"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="399" mass="43618" checksum="0CC753C5BAB8AA43" modified="2005-11-22" version="1">MKYIVLLGDGMSDEAVKDLDGKTPLQAAKTPHMDVMARRGRIGLAHTVPKGLPPGSDVANLSVFGYDPRTCYTGRSPLEAASMGVQLGPDDVAFRVNLVNLLPTKGTLVMNDYSAGHISTEEGRELIEAIQQQIGDDEFQFYPGVGYRHLMVWRNGKSGMSATPPHDISGKSILDYLPKGEGADKLIYLMNSSQMILNNHPQYRRRLEADKIPANSIWLWGHGKAPRMEPFKEKFGLAGAVISAVDLINGIGIGAGLDVIRVEGATGYLDTNYEGKVQAALEALETHDYVYLHVEAPDEASHSGNLSHKLQAIEDFDARVVGPIMEGIRRFGSFRILCTPDHPTPLRLKTHTGAPVPFIIYDGGESEDDSIAGYDEDSARTSGLVLEEGHRLMELLLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VX8</accession>
    <name>Q39VX8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoglutarate:ferredoxin oxidoreductase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">korA</name>
        <name evidence="3" type="ordered locus">Gmet_1362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513146.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1362"/>
    <dbReference type="EnsemblBacteria" id="ABB31596">
        <property type="protein sequence ID" value="ABB31596"/>
        <property type="gene ID" value="Gmet_1362"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1362"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_0_1_7"/>
    <dbReference type="OMA" id="DFIQGDE"/>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="17"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="275"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="377" mass="40925" checksum="2979A6C51E9E8447" modified="2005-11-22" version="1">MAKKVAFLQGNEAAAQGALYAGCRFFAGYPITPSTEVAEVLSAELPKVGGKFMQMEDEIGAMAALIGASLTGSKVLTSTSGPGLSLKQENIGYACIAEVPAVIVNVMRGGPSTGMPTGPSQSDVMCAKWGTHGDHPAICLVPASVQEVFEETVRAFNLAEKYRTPVMIMPDEIVAHMRERIVFPEPGELEVIDRKGPSVPPEQYKPYDTSFGDVPPLAAFGSGYKFHVTGLNKMQDGFPTTKAEIVQAEEERQVRKVEANKADIMRWEEYLCDDAEVIVVAFGSTSRSARFAVNEARKNGIKAGLFRLITFWPFPEERLLELSKKVKAFVTPEMNLGMCTGVVKGCIEGNAPVIGIFRVDGEPINPDQILDKMKEVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VY0</accession>
    <name>MDH_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Malate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mdh</name>
        <name type="ordered locus">Gmet_1360</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of malate to oxaloacetate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 3 family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513148.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VY0"/>
    <dbReference type="SMR" id="Q39VY0"/>
    <dbReference type="STRING" id="269799.Gmet_1360"/>
    <dbReference type="EnsemblBacteria" id="ABB31594">
        <property type="protein sequence ID" value="ABB31594"/>
        <property type="gene ID" value="Gmet_1360"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1360"/>
    <dbReference type="eggNOG" id="COG0039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045401_2_1_7"/>
    <dbReference type="OMA" id="MGWTSQA"/>
    <dbReference type="OrthoDB" id="870724at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00487">
        <property type="entry name" value="Malate_dehydrog_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="SSF56327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01763">
        <property type="entry name" value="MalateDH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="chain" id="PRO_0000241950" description="Malate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00487"/>
        </source>
    </evidence>
    <sequence length="317" mass="33729" checksum="6D1F4966D0D0B3DC" modified="2005-11-22" version="1">MARKKISLIGGGQIGGVLAQLCALRELGDVVMFDIVEGLPQGKMLDIAEVGPVDGFDVCLKGTNSYADIAGSDVVIVTAGLPRKPGMSRDDLIEVNSKIMTQVAEGIKQYAPNSFVIVISNPLDAMVTLCQKITGFPYNRVIGQAGVLDSSRFAAFIAWELGVSVKDVVAVTLGGHGDDMVPLVRYTSVCGIPVMELLERKYKDKAKAKEVMEAMVKRTRGAGGEVVALLKTGSAFYSPASAAIAMTESILKDQKRVLPTCCFLQGEFGVNGYYVGVPAVLGENGVEQIIQFNLDAEEQAMMDKSVAAVKSLVDSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VZ0</accession>
    <name>Q39VZ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc metalloendopeptidase, M23 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513158.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1350"/>
    <dbReference type="MEROPS" id="M23.009"/>
    <dbReference type="EnsemblBacteria" id="ABB31584">
        <property type="protein sequence ID" value="ABB31584"/>
        <property type="gene ID" value="Gmet_1350"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1350"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1123292_0_0_7"/>
    <dbReference type="OMA" id="ETFTNTP"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025392">
        <property type="entry name" value="DUF4124"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13511">
        <property type="entry name" value="DUF4124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4124" evidence="3">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="109"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="240" mass="25338" checksum="0A16FFF6EC34E426" modified="2005-11-22" version="1">MRKSTLIIAALVIVLPREGVADIYRYVDEEGVVCFTDAPGKSGATLVMKERPAPRRGRRSIPGHLAATGIGEKPSQASSPTFSPTLPVHGRISSLVGLRHDPINGNLREHHGIDIAIAEGTAVRPVAPGRVVFAGLRGGYGNMVIVDHGDGTITLYAHNSVNLVAENDSVDGTSPIALSGSTGRSTGPHLHFEAWRGETNITSTFLAGGPSMGSASNRRKVDAIRRIVQADGTLYLSNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VZ4</accession>
    <name>Q39VZ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polysaccharide chain length determinant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_1346</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1346"/>
    <dbReference type="EnsemblBacteria" id="ABB31580">
        <property type="protein sequence ID" value="ABB31580"/>
        <property type="gene ID" value="Gmet_1346"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1346"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051175_1_0_7"/>
    <dbReference type="OMA" id="WLIQDIN"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003856">
        <property type="entry name" value="LPS_length_determ_N_term"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02706">
        <property type="entry name" value="Wzz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Wzz" evidence="8">
        <location>
            <begin position="14"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="9">
        <location>
            <begin position="297"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="401" mass="43458" checksum="9AF7A40D53F99FF2" modified="2005-11-22" version="1">MTDPMRNEQMVEEDEINLLELLQVLVRRKRLIAVMCVAAALLSAAYSLTLPNIYTGTARVLPPQKDGGGGLSALLGGQAGALAGLAGVGGLGGGADLYVGILKSRSVADAVIKKLDLQKELETKTPDETRTKLQNVVKIQAGKDGIITVAADSRNPQLAARLANTFVDELGKKSVELNLTKAGTERIFLEKRLDVVKADLKKAEEALRGFQEKNRAFKVDDQATATIEGAAKLKAEIVSKEVQLASLRSYQTNENPEVKAVEAALARLRGQLGALTGGGRSNDLMLSAGAMPTLGLEYVRLMREVKTQEAIFEQLTKQYEVAKLGEAKDSSSIQVLDEAVAPQKKSKPKRSLIVILSTVTALFLGIFIAFIQEYAQKMSDEDRTRWNEIRESLSPTRARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WD0</accession>
    <name>Q39WD0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1207</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512163.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1207"/>
    <dbReference type="EnsemblBacteria" id="ABB31444">
        <property type="protein sequence ID" value="ABB31444"/>
        <property type="gene ID" value="Gmet_1207"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1207"/>
    <dbReference type="eggNOG" id="ENOG5033QC9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087248_0_0_7"/>
    <dbReference type="OMA" id="ACMRQIA"/>
    <dbReference type="OrthoDB" id="1593413at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="212" mass="24007" checksum="0FE58E6291AE6108" modified="2005-11-22" version="1">MAKKKRVQRSKEDLKQELRDQITLLQHACEKYDSGLEAIGKHIALSLRVLLHHYGQSRALLEQLGLRDVKYYDSAGPINPKNLLSECNLIVLHASSNGGKYIPQISAGGGPFPPRKVTLVEWWNEPVLKDQQGRVFNRRDLILNVADTDGGAHVDPELEEAYMDLSRNNSLGWVFGDGNIEKAFEGRTELACMRQIAHELLMTLREIFPDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WE0</accession>
    <name>Q39WE0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512173.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1197"/>
    <dbReference type="EnsemblBacteria" id="ABB31434">
        <property type="protein sequence ID" value="ABB31434"/>
        <property type="gene ID" value="Gmet_1197"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1197"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_768951_0_0_7"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223361" evidence="1">
        <location>
            <begin position="27"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="392" mass="42686" checksum="75750C17BEBF202F" modified="2005-11-22" version="1">MNARQVLKRMNQVACLVLLGTGAAVSSITLETATSPAAALALTMADCRVCHASGNNVTRHHNLITTKGLDCLDCHRLVLDPVTNTYVFAPFRDCTSCHSTLVHFDKHGLYIANWQTMSGVVPGTAPLWTQIMTFSLVNPAQNQYQVCYKCHSYNAFGPATTGVSPVVSHSNIKLTDQAMEFNPNNRSAHPIQVPLNSQTGSYAPKALRSNQMSLGWTNVGTQTMVCSDCHAAPPTGSTGATKYLLKGPRTYWPYNRNGQLWTLGDVRSNANNWSTDLFCVNCHPIYSGGSWENNVHGEGDHHDSMTIGGTRFNGAPCVSCHVEIPHGYRISRLIGYDTDPAPYGTVQANGTKVQVLKGFRKASSPTNYGEGNCYSTVGACDEHNSRSMTYDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WF7</accession>
    <name>Q39WF7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">5-formyltetrahydrofolate cyclo-ligase</fullName>
            <ecNumber evidence="3">6.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6S)-5-formyl-5,6,7,8-tetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10488"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5-formyltetrahydrofolate cyclo-ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513445.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1179"/>
    <dbReference type="EnsemblBacteria" id="ABB31417">
        <property type="protein sequence ID" value="ABB31417"/>
        <property type="gene ID" value="Gmet_1179"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1179"/>
    <dbReference type="eggNOG" id="COG0212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066245_1_1_7"/>
    <dbReference type="OMA" id="MPLVGFD"/>
    <dbReference type="OrthoDB" id="1816478at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030272">
        <property type="term" value="F:5-formyltetrahydrofolate cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002698">
        <property type="entry name" value="FTHF_cligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024185">
        <property type="entry name" value="FTHF_cligase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23407:SF1">
        <property type="entry name" value="PTHR23407:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01812">
        <property type="entry name" value="5-FTHF_cyc-lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006806">
        <property type="entry name" value="FTHF_cligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02727">
        <property type="entry name" value="MTHFS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="3"/>
            <end position="7"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="130"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="189" mass="20806" checksum="F8FE77504BD1C27B" modified="2005-11-22" version="1">MPKRKLRQCMLDKRRTLAAEERRYSGRLIQQAFVALPEFAEARIVALYSPIGGEVETGEVMEAALKEGKIVIFPVVCGDCLRFVKVSDPSEMTKGAFGIAEPCLTGEAYPPDAADLVVVPGVAFDRAGKRIGFGKGYYDRALHHLEGSGKLVAFCYDFQLVDEIVAESHDVAVDVIITEKRVITLHGYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WG4</accession>
    <name>Q39WG4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1172</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513438.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1172"/>
    <dbReference type="EnsemblBacteria" id="ABB31410">
        <property type="protein sequence ID" value="ABB31410"/>
        <property type="gene ID" value="Gmet_1172"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1172"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1813030_0_0_7"/>
    <dbReference type="OMA" id="VNFQSKT"/>
    <dbReference type="OrthoDB" id="1755621at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223563" evidence="2">
        <location>
            <begin position="18"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="145" mass="15147" checksum="5CA8A2227C770CA5" modified="2005-11-22" version="1">MKKTVLVALAVASLAAAGCKEKPKAPETTAPQQSGMPAQPGQGQMPSDAVHGGANPHAGLKAVEVPAGAGHKGKVVSTMDAAGYTYLEVEEKGQKLWVAVMQTKVKVGDEVEFPDSPPMVNFHSKTLNRTFEKIIFAPGVRIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WJ4</accession>
    <name>Q39WJ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513406.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1142"/>
    <dbReference type="EnsemblBacteria" id="ABB31380">
        <property type="protein sequence ID" value="ABB31380"/>
        <property type="gene ID" value="Gmet_1142"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1142"/>
    <dbReference type="eggNOG" id="COG3292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_477130_0_0_7"/>
    <dbReference type="OMA" id="GHFHPRR"/>
    <dbReference type="OrthoDB" id="1052907at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006521">
        <property type="entry name" value="Tail_protein_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09684">
        <property type="entry name" value="Tail_P2_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="502" mass="55503" checksum="B34C6E8F323F2CAA" modified="2005-11-22" version="1">MATDKPTTTTGTQLYGILPEVYRTRDSVEFGGEGDLARFLDTCGELLDRIRATMDQRLADSFPDNPPSGLSCQPWLIPYFAQLLDVRLVSPDEEGRRDEVANAVAWRQRKGTLTAIEQIAEAVGQMEVEIQEGWRRSAVTPRIGMPQLPAGALGEDPRFDDFQDHPLWAARHPDLPAATTDFRYPARAMEVVVAAGEFPANPAAKLTTFAGRPVWWRQVNPHGAPCFPGSFDDVSRRTVDLRTPDWRQGHIHPKRVILSAPPPLGFFEPGRFPVHTGDMLLDEDQEHLLEDLIIDGTLKVTAGTVKLKRCAVRVLEVTVPAGTMEEPAVDARECLFDKLAVPGLARFEYCTVLGLCECGRLQASDSLFAGTLDLKPGMLKNPHCIRFSRIPPGTAAAALLTHRNTTERPVFYAFEFDEVGETVRRTAKFGEPGCAVFHPATPEAVHFGAEDGGEMGVHHGWRYSLLMAAVLDKLKEFLPVGMEAVIVPDLRLHRKPFPPCSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WL2</accession>
    <name>Q39WL2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase (unknown stereospecificity)</fullName>
            <ecNumber evidence="3">2.3.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1124</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the citrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.16" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513388.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1124"/>
    <dbReference type="EnsemblBacteria" id="ABB31362">
        <property type="protein sequence ID" value="ABB31362"/>
        <property type="gene ID" value="Gmet_1124"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1124"/>
    <dbReference type="eggNOG" id="COG0372">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022049_2_1_7"/>
    <dbReference type="OMA" id="NEAVMHM"/>
    <dbReference type="OrthoDB" id="1412360at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="PTHR11739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="438" mass="49460" checksum="E114386A4171272A" modified="2005-11-22" version="1">MGLKETLKQKIEEFRPRTTRLVKEFGKVKIDEVTIEQCIGGARDIRSLVTDISYLDPQEGIRFRGKTIPETFAALPKAPGSDYPTVESFWYFLLTGEVPTQAQVDEVLTEWKVRQEVPQYVFDTIRTLPRDSHPMAMLSVGITAMQRDSKFAALYNAGKFNKLSAWESVYEDACDIVARIPVIAAFIYNLKYKGDKQIAIDPALDMGANFAHMIDQGDAYKDVARMYFILHSDHESGNVSAHTTHLVHSALSDPYYAYAAGLNGLAGPLHGRANQEVLDWTIKFQEKYCKDQEPTKELITRALWDTLNSGQVIPGYGHAVLRKTDPRYISQREFCQKHLPEDPLFKLVSMIFEVAPGVLTEHGKTKNPWPNVDAQSGVIQWHYGVKEWDFYTVLFGVGRALGCMANITWDRGLGYAIERPKSVTTPMLEEWAAKGGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WQ4</accession>
    <name>Q39WQ4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cheA36H</name>
        <name evidence="8" type="ordered locus">Gmet_1080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513736.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1080"/>
    <dbReference type="EnsemblBacteria" id="ABB31320">
        <property type="protein sequence ID" value="ABB31320"/>
        <property type="gene ID" value="Gmet_1080"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1080"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_6_7"/>
    <dbReference type="OMA" id="MMDMAKS"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="7">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="346"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="6">
        <location>
            <begin position="550"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="246"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="682" mass="74135" checksum="CED2E5EF4C5D705C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WR2</accession>
    <name>Q39WR2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CRISPR-associated endonuclease Cas1</fullName>
            <ecNumber evidence="8">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 9" type="primary">cas1</name>
        <name evidence="9" type="ordered locus">Gmet_1072</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer, forms a heterotetramer with a Cas2 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CRISPR-associated endonuclease Cas1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513728.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1072"/>
    <dbReference type="EnsemblBacteria" id="ABB31312">
        <property type="protein sequence ID" value="ABB31312"/>
        <property type="gene ID" value="Gmet_1072"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1072"/>
    <dbReference type="eggNOG" id="COG1518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052779_1_0_7"/>
    <dbReference type="OMA" id="YYVGSFY"/>
    <dbReference type="OrthoDB" id="1581397at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09721">
        <property type="entry name" value="Cas1_I-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01470">
        <property type="entry name" value="Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002729">
        <property type="entry name" value="CRISPR-assoc_Cas1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042206">
        <property type="entry name" value="CRISPR-assoc_Cas1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019856">
        <property type="entry name" value="CRISPR-assoc_Cas1_DVULG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042211">
        <property type="entry name" value="CRISPR-assoc_Cas1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01867">
        <property type="entry name" value="Cas_Cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00287">
        <property type="entry name" value="cas1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03640">
        <property type="entry name" value="cas1_DVULG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="344" mass="38718" checksum="7D6059958305A0E9" modified="2005-11-22" version="1">MKQILNTLYVMTQGAYVCLDHETVKVEVKGALQMQVPLHHLGAIVTMGNVMMSPFIMARCAEDGRALVILDRNGKFKCRVVGKTSGNVLLRQTQYEAVRDRERSAAIARNMVAGKVKNARQILMRGARETTDADESAVLRKAGDTLADALFHLKDATDIDHVRGLEGEAANAYFQVFDRMVKEEERPAFRMNGRNRRPPLDPMNALLSFLYTLLLNDCISAVEGVGLDSQMGFLHVLRPGRPSLGLDIMEEFRAVLADRLALTLINRKQITEKHFEVRPGGATYLDDAGRKEVIMAYQKRKQDEFHHPVLDQKVPFGLLPHVQARLLARHLRGDLEQYTPVLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WR5</accession>
    <name>Q39WR5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transposase of ISGme1, IS5 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0283</name>
        <name evidence="9" type="ordered locus">Gmet_1069</name>
        <name evidence="10" type="ordered locus">Gmet_2091</name>
        <name evidence="11" type="ordered locus">Gmet_2240</name>
        <name evidence="12" type="ordered locus">Gmet_2488</name>
        <name evidence="13" type="ordered locus">Gmet_2883</name>
    </gene>
    <organism evidence="9 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="9">GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="9">GS-15</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the transposition of the insertion sequence IS5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transposase 11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365646.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30528">
        <property type="protein sequence ID" value="ABB30528"/>
        <property type="gene ID" value="Gmet_0283"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31309">
        <property type="protein sequence ID" value="ABB31309"/>
        <property type="gene ID" value="Gmet_1069"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32320">
        <property type="protein sequence ID" value="ABB32320"/>
        <property type="gene ID" value="Gmet_2091"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32467">
        <property type="protein sequence ID" value="ABB32467"/>
        <property type="gene ID" value="Gmet_2240"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32712">
        <property type="protein sequence ID" value="ABB32712"/>
        <property type="gene ID" value="Gmet_2488"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33101">
        <property type="protein sequence ID" value="ABB33101"/>
        <property type="gene ID" value="Gmet_2883"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0283"/>
    <dbReference type="KEGG" id="gme:Gmet_1069"/>
    <dbReference type="KEGG" id="gme:Gmet_2091"/>
    <dbReference type="KEGG" id="gme:Gmet_2240"/>
    <dbReference type="KEGG" id="gme:Gmet_2488"/>
    <dbReference type="KEGG" id="gme:Gmet_2883"/>
    <dbReference type="eggNOG" id="COG3039">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021293_3_2_7"/>
    <dbReference type="OMA" id="WIKTVGG"/>
    <dbReference type="OrthoDB" id="568762at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008490">
        <property type="entry name" value="Transposase_InsH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05598">
        <property type="entry name" value="DUF772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="DUF772" evidence="7">
        <location>
            <begin position="53"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="6">
        <location>
            <begin position="198"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB33101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="358" mass="40406" checksum="1691327EE67E20C1" modified="2005-11-22" version="1">MRGAETKTEALFCYLSPESYVPKDHPLRSIRAMVDKALAELSPQFEAMYSHTGRPSIPPEQLLKALLLQALYTIRSNRLLVEQISYSILFRWFVGLALDEKVWDHSSFSTNLERLIDTDVARLLLAKVVEQARRAKLLSDEHFSVDGTLIEAWASIKSFRPKDGPKPPVGRNTERDFHGEKLKNDTHASTTDPDARIARRSSGKEAKLSYHGHALMENRNGIIVDARITHATGTAERDTAVEMIADVAGNKRITMGGDKGYDTKECVKDLRALKVTPHIAQNTANRRSAIDGRTTRHEGYKTSLRIRKRIEEAFGWLKTVGNLRKTRHRGIAKVDWYFTMAIAAYNLVRLRNLGTKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XK1</accession>
    <name>Q39XK1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmic solute-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513526.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0781"/>
    <dbReference type="EnsemblBacteria" id="ABB31023">
        <property type="protein sequence ID" value="ABB31023"/>
        <property type="gene ID" value="Gmet_0781"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0781"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_7_1_7"/>
    <dbReference type="OMA" id="MLMGITD"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PBP_domain" evidence="1">
        <location>
            <begin position="29"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="281" mass="29453" checksum="6A6AECCF921D65C6" modified="2005-11-22" version="1">MRHSIGPALSLVAALMFFALLTGPCRVEAAGAETIRVNGSGSALYVMRPLIKAYLKAHPGVRIEMEKPLGSSGAVKALLAGGLDMVVSSKVLKSEEAAQGGISREYGKMPLVVVTGKQVSKRDITTKELEDIYSGKVRTWPNGEPIRLVLRPDADIDTTILAGLSPAMGKAMKAAHSHPGMIVAVTDPESDEAVAKTPGSLGTAALSSILVEKAPLNVLALNGIKPSVKTLANGTYPLAKDIRFITTKHTPPATLKFIDFIYSPQGRAIAGKAGVLVPVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XM0</accession>
    <name>Q39XM0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Response receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513507.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0762"/>
    <dbReference type="EnsemblBacteria" id="ABB31004">
        <property type="protein sequence ID" value="ABB31004"/>
        <property type="gene ID" value="Gmet_0762"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0762"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1132328_0_0_7"/>
    <dbReference type="OMA" id="CDERELW"/>
    <dbReference type="OrthoDB" id="1258741at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="245" mass="27649" checksum="4C6E8A40D28CE827" modified="2005-11-22" version="1">MSDTQRQPEIWLMGLGCDEERSAKVRDYLTYAGYRVTCHGMDDFADGRPLGVVLDLSPFSRDGWGILLDIKNNAATRDVPILPVYLSQEGKVGGIFPAVGFFTLPVDPDYLLTKLAVLGLTEDAETWDLQVMVVSKRGEEHLAKALTSLGFDVVNAYTGKEAVALATIGRPFMVFCCVMLPDMSAFELMERFRLFPQVRNVPFFVLVKDAMKEGERAALSRQVEHLVRKKELTREEFATHLRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XV2</accession>
    <name>Q39XV2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosyl-(Nitrogenase)-activating glycohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">draG</name>
        <name evidence="1" type="ordered locus">Gmet_0680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514071.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0680"/>
    <dbReference type="EnsemblBacteria" id="ABB30922">
        <property type="protein sequence ID" value="ABB30922"/>
        <property type="gene ID" value="Gmet_0680"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0680"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024566_8_2_7"/>
    <dbReference type="OMA" id="PGTWTDD"/>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013479">
        <property type="entry name" value="ADP-ribosyl_diN_reduct_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02662">
        <property type="entry name" value="dinitro_DRAG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="300" mass="32722" checksum="D1E83A318DF93E89" modified="2005-11-22" version="1">MPHLLDHHDIRSRARAAFIGLAVGDALGAPVEFMTAGEIRSKYGVLREIVGGGWLRLKPGQVTDDTEMSLCVARAIVAAGGWSLRGIAEEFAGWLRTKPVDVGDTCRRGIRNFMLKGSLETPFNQWDAGNGAAMRMLPAALYTLGDDDLLQRCALEQARITHNHPLSDAACITLGRIVHLALRGASKNRLHREADLLVADLPAFTFTPYRGLATGYVADTVQTVFHHFFRGRSFEECLVGTVNQGGDADTTGAICGMVAGAFYGMEGIPQRWLKKMDRKTMAEIAELSTRLIALSTPLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XX7</accession>
    <name>Q39XX7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybhR-1</name>
        <name evidence="7" type="ordered locus">Gmet_0655</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514263.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0655"/>
    <dbReference type="EnsemblBacteria" id="ABB30897">
        <property type="protein sequence ID" value="ABB30897"/>
        <property type="gene ID" value="Gmet_0655"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0655"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_8_0_7"/>
    <dbReference type="OMA" id="WGQELIE"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="376" mass="41986" checksum="F4215124372073EC" modified="2005-11-22" version="1">MLERLRCMLVKEIIQALRDPRMRFILFIIPAVQTVIFGYAVNTDVRNVTTAVYDLDNSPESRDLVARFQRSGYFLITQRINHESRVRELMDRGEVKAILRINRGFGAGLGGGRTAPLQIILDGTDSNTAGIVLNYASRITARLNDELRGAQLPRSAGARVFAGGVQLQSRAWFNENLESSNYYVPAVIANIVLIITMLLSGMAVVREKEIGTMEQIIVTPISRSEFILGKTIPFVLIGFIDVAVITAVSKFWFQVPIRGSLPLLFGSTALFLMSTLGFGLFISTISTTQQQAMMSSFFFIFPAMLLSGFAFPIENMPRVIQYFTYLNPLRYYLVIIRGIFLKGVGVDILWPQMTGLLVLGSVILGFAVKRFRKTLA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XY8</accession>
    <name>RL30_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmD</name>
        <name type="ordered locus">Gmet_0644</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514254.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XY8"/>
    <dbReference type="SMR" id="Q39XY8"/>
    <dbReference type="STRING" id="269799.Gmet_0644"/>
    <dbReference type="EnsemblBacteria" id="ABB30886">
        <property type="protein sequence ID" value="ABB30886"/>
        <property type="gene ID" value="Gmet_0644"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0644"/>
    <dbReference type="eggNOG" id="COG1841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131047_2_1_7"/>
    <dbReference type="OMA" id="GKQNQRD"/>
    <dbReference type="OrthoDB" id="2084745at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01371_B">
        <property type="entry name" value="Ribosomal_L30_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="L30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_L30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="PTHR15892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002211">
        <property type="entry name" value="Ribosomal_L30_bac-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="SSF55129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000056044" description="50S ribosomal protein L30">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01371"/>
        </source>
    </evidence>
    <sequence length="59" mass="6245" checksum="067B59D2A2091497" modified="2005-11-22" version="1">MSAGLKITLIKSQIGAPTAQKAVLNGMGLNKLNKTVVLKNTPEIVGMIAKVSHMVKVEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y02</accession>
    <name>RS19_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsS</name>
        <name type="ordered locus">Gmet_0630</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514241.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y02"/>
    <dbReference type="SMR" id="Q39Y02"/>
    <dbReference type="STRING" id="269799.Gmet_0630"/>
    <dbReference type="EnsemblBacteria" id="ABB30872">
        <property type="protein sequence ID" value="ABB30872"/>
        <property type="gene ID" value="Gmet_0630"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0630"/>
    <dbReference type="eggNOG" id="COG0185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144911_0_1_7"/>
    <dbReference type="OMA" id="FPEMVGH"/>
    <dbReference type="OrthoDB" id="1893906at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_S15/S19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_S19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005732">
        <property type="entry name" value="Ribosomal_S19_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_S19_S15_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="PTHR11880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="SSF54570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01050">
        <property type="entry name" value="rpsS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000265365" description="30S ribosomal protein S19">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00531"/>
        </source>
    </evidence>
    <sequence length="93" mass="10330" checksum="64DF05A06F23BF33" modified="2005-11-22" version="1">MARSIKKGPFVDDHLAKKVAAEGTGSKKVLKTWSRRSTITPDFIGLTFAVHNGKKFIPVFVTENMVGHKLGEFAPTRTFYGHAADKKSKLKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y71</accession>
    <name>Q39Y71_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512257.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0560"/>
    <dbReference type="EnsemblBacteria" id="ABB30803">
        <property type="protein sequence ID" value="ABB30803"/>
        <property type="gene ID" value="Gmet_0560"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0560"/>
    <dbReference type="HOGENOM" id="CLU_1193435_0_0_7"/>
    <dbReference type="OMA" id="TYWVVAR"/>
    <dbReference type="OrthoDB" id="1525662at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="229" mass="24245" checksum="ED5AE4CE3D1A52AE" modified="2005-11-22" version="1">MRGLFWLAAAWLLLFCAVPDGARAALLRGRVADIDGKPLAGAKLFVYDSANVRRPATFISPPSAADGTVVVTVPPGTYWVVARLKKDDSYGPLMPGEKHSGEPVVVDLTAEAEAAQEFTVADIRDLGRKHRAIATESVRLSGRVLDGEGKPVANAYVFASATRDGGRIPDYLSAWTGADGGYTLMIPAGRTYYVGSATRFPMSAWHPSTEVVPAAGKTEVALDVGLALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y74</accession>
    <name>Q39Y74_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">omcP</name>
        <name evidence="2" type="ordered locus">Gmet_0557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512254.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0557"/>
    <dbReference type="EnsemblBacteria" id="ABB30800">
        <property type="protein sequence ID" value="ABB30800"/>
        <property type="gene ID" value="Gmet_0557"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0557"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076833_0_0_7"/>
    <dbReference type="OMA" id="SEPNCER"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223619" evidence="1">
        <location>
            <begin position="24"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="280" mass="29875" checksum="CB0F6B87F22252D6" modified="2005-11-22" version="1">MKKRFLATAVMAAIMAWGAIVNAGPGKIKNTVHNMSSVAPSGFVGTRHWYSTDTDEVCVFCHTPHNAKPAQPLWNKVNPTQAFNMYTSSTTLTSVAKKVTAPSPESLLCLSCHDGRTAINVLHNSSAGIDAGGGDKKLMIGGVYDDPTAPAGVTGIPMNIDTFTIPNTYRANLGRTEADRYAGTNLMDDHPISFSYTAAYNEKVGSGSSAINPIATPLSKGLRFFGSNNRMECSTCHDPHVDYGMDFDGNPTYSGGNTALRPFLVRDNTGSAMCLACHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y97</accession>
    <name>Q39Y97_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512230.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0534"/>
    <dbReference type="EnsemblBacteria" id="ABB30777">
        <property type="protein sequence ID" value="ABB30777"/>
        <property type="gene ID" value="Gmet_0534"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0534"/>
    <dbReference type="eggNOG" id="ENOG502ZR74">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_857281_0_0_7"/>
    <dbReference type="OMA" id="INCLVCH"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223458" evidence="1">
        <location>
            <begin position="26"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C554" evidence="2">
        <location>
            <begin position="58"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="324" mass="35224" checksum="36041ADB203C7098" modified="2005-11-22" version="1">MMLKPVWLKLSVAAVAFCAATPVFAEKAGIGWQGTISAKAGKAKTMAELAKMYDSSSCIECHQETHNDWNKSIHARSIFGTSRTAATLKTAVVNGLMEWPYSGVKKPEDVKVEHLMGCAKCHLPQLADAEDSVAKEIIATVDNWQDALKKKDTVKASAEADKLKSLNISCLVCHNRNAITHKWTDGYPQAGVVYGSKDGDHPSDAFPKMKASPIMSESIQCGQCHGLGPNMELDNPTQCCTSYGSYLWAYTAEGGSETCQDCHMKKSKLGHNMQSYRDPGMAKAAVEFKAEARAFHWRDGATIKPKAVVKVEMVNRAGHSIPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YA7</accession>
    <name>Q39YA7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512220.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0524"/>
    <dbReference type="EnsemblBacteria" id="ABB30767">
        <property type="protein sequence ID" value="ABB30767"/>
        <property type="gene ID" value="Gmet_0524"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0524"/>
    <dbReference type="eggNOG" id="COG4986">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036171_2_0_7"/>
    <dbReference type="OMA" id="FGTQWYI"/>
    <dbReference type="OrthoDB" id="1065003at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="368"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="441"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="378"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="579" mass="64155" checksum="9F294C0D6DE7DBAC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YD4</accession>
    <name>TAL_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transaldolase</fullName>
            <ecNumber evidence="1">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tal</name>
        <name type="ordered locus">Gmet_0497</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transaldolase family. Type 3B subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512193.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YD4"/>
    <dbReference type="SMR" id="Q39YD4"/>
    <dbReference type="STRING" id="269799.Gmet_0497"/>
    <dbReference type="EnsemblBacteria" id="ABB30740">
        <property type="protein sequence ID" value="ABB30740"/>
        <property type="gene ID" value="Gmet_0497"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0497"/>
    <dbReference type="eggNOG" id="COG0176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079764_0_0_7"/>
    <dbReference type="OMA" id="VRHPMHV"/>
    <dbReference type="OrthoDB" id="784333at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00956">
        <property type="entry name" value="Transaldolase_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00494">
        <property type="entry name" value="Transaldolase_3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022999">
        <property type="entry name" value="Transaldolase_3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004731">
        <property type="entry name" value="Transaldolase_3B/F6P_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033919">
        <property type="entry name" value="TSA/FSA_arc/bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="PTHR10683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00875">
        <property type="entry name" value="fsa_talC_mipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0570">Pentose shunt</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000060464" description="Probable transaldolase">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00494"/>
        </source>
    </evidence>
    <sequence length="214" mass="23228" checksum="F68B7574C999C1CA" modified="2005-11-22" version="1">MKFFIDTADVNEIREAHELGLVDGVTTNPSLIAKSGRKFEEVIKEITGIVDGPISAEVVSLDHDGMIREAEELAAIHKNIVIKLPMTPEGLKACTTLTKKGIKTNVTLIFTAMQALLAAKAGATYVSPFVGRLDDISQDGMGIIDDIKTIFDNYGYTAEIIVASVRNPIHVLNAALIGADIATIPYSVMLQLAKHPLTDAGIERFLKDWEKVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YE2</accession>
    <name>Q39YE2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0489</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512185.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0489"/>
    <dbReference type="EnsemblBacteria" id="ABB30732">
        <property type="protein sequence ID" value="ABB30732"/>
        <property type="gene ID" value="Gmet_0489"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0489"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4886">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_599586_0_0_7"/>
    <dbReference type="OMA" id="RIYLYQT"/>
    <dbReference type="OrthoDB" id="1111900at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="452" mass="50948" checksum="73B97CF3EAD6D0E1" modified="2005-11-22" version="1">MKSGYKRTPTADEQELERKRREFHALERRLARLEHDLEDLREEIREFEKLYSVQMADRIRELDQLRQELARARSGAAARSRTGDGGERRHYGFQDDEPELEDIPRVKPGTAPTVKNEGIRNVYRRVAKAIHPDFAESDEDRRRRQKLMAEANRAYAEEDRVTLQAILEEWQLSPETAVAVGTAGELALVIRRIGRVVERIRGVELEMARLRNTDLYRLIQRVQDARWRGHDIIAEMASRLDAEILASCRTLNELGRGRHADDAPQAAQTPPSPPAGTFRTVRFPADRPLGTLFVRERNSGSFLDWKRLGEALGAVAVPAGKGLRLDVREGAVADLDLLGTLQVDDLQACFLYGIADDDLTHILRLTGIRELYLSGEGITSEGIVHLLELKNLERIYLYDTLVTDAGLASLRYLPRLCSLTISNAPVTDGGLDRLRLALPGCRVVILQSGKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YL1</accession>
    <name>Q39YL1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365665.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0420"/>
    <dbReference type="EnsemblBacteria" id="ABB30663">
        <property type="protein sequence ID" value="ABB30663"/>
        <property type="gene ID" value="Gmet_0420"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0420"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_40_3_7"/>
    <dbReference type="OMA" id="TEVFWAA"/>
    <dbReference type="OrthoDB" id="1570162at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025996">
        <property type="entry name" value="TetR_C_WHG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13305">
        <property type="entry name" value="TetR_C_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="215" mass="24822" checksum="035ED5B865439E28" modified="2005-11-22" version="1">MTLRERRQKHKAQFRQEILDASRELFSQIGYERFSMRKLAAKIEHSPTTIYLYFRDKDDLLYSLCEELFAKLFQSYQDISRGENDPRQVLRLCLLRYIEFGLANPGHYKVAFFTSPVVYGSPTEFLQKDSMGRRTYFHILRTVEETMAAGMLRPMDADLLAQTVWVAAHGVVTSRIYSADFPMVDAVLQAETLVDGLLAGFSVKNFFGTNIYTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YN2</accession>
    <name>Q39YN2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">GTP cyclohydrolase 1 type 2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yqfO</name>
        <name evidence="4" type="ordered locus">Gmet_0399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512371.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0399"/>
    <dbReference type="EnsemblBacteria" id="ABB30642">
        <property type="protein sequence ID" value="ABB30642"/>
        <property type="gene ID" value="Gmet_0399"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0399"/>
    <dbReference type="eggNOG" id="COG0327">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037423_1_0_7"/>
    <dbReference type="OMA" id="EVAYDIY"/>
    <dbReference type="OrthoDB" id="502462at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017221">
        <property type="entry name" value="DUF34/NIF3_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="PTHR13799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037489">
        <property type="entry name" value="UCP037489_NIF3_YqfO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="SSF102705"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR037489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="372" mass="40037" checksum="9E23D82261502F05" modified="2005-11-22" version="1">MITPKVSDIVGIVNKIAPHGLAEEWDNVGLMVGDPSAPATRIMVALDGTPDTIDAAIADRCQILLTHHPFIFRPLKHISSADPTGRLVLKAASHALAVISLHTNFDIASGGMNDLLAERLGVSNCRPLKVTTSESLVKLVVFVPTGHEERVRDALFRFSGVVGAYSDCSFQCAGTGTFKPLAGAQPFIGQVGRREYVEESRIEVLLEKRNLPAAVTALVKAHPYEEPAFDLFPLLNRGPEQGLGRIGVLAEETTVSAFADEVKERLGLAGVRFVGDGARPVRKVALCGGSGMSLLRDAQRQGADVLVTGDVKYHEGRDAEALGVALVDGGHFGTEVLMVESVANRMAAELASRRFEAEVIPFRVERDPFTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YN7</accession>
    <name>Q39YN7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 13">DNA primase</fullName>
            <ecNumber evidence="12">2.7.7.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 17" type="primary">dnaG</name>
        <name evidence="17" type="ordered locus">Gmet_0394</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13 14">Binds 1 zinc ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer. Interacts with DnaB.</text>
    </comment>
    <comment type="domain">
        <text evidence="12">Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the DnaG primase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.101" evidence="12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512366.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0394"/>
    <dbReference type="EnsemblBacteria" id="ABB30637">
        <property type="protein sequence ID" value="ABB30637"/>
        <property type="gene ID" value="Gmet_0394"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0394"/>
    <dbReference type="eggNOG" id="COG0358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013501_3_1_7"/>
    <dbReference type="OMA" id="LMWPIRD"/>
    <dbReference type="OrthoDB" id="1071997at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003896">
        <property type="term" value="F:DNA primase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03364">
        <property type="entry name" value="TOPRIM_DnaG_primases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00974">
        <property type="entry name" value="DNA_primase_DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013264">
        <property type="entry name" value="DNA_primase_core_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037068">
        <property type="entry name" value="DNA_primase_core_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019475">
        <property type="entry name" value="DNA_primase_DnaB-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006295">
        <property type="entry name" value="DNA_primase_DnaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036977">
        <property type="entry name" value="DNA_primase_Znf_CHC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030846">
        <property type="entry name" value="DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034151">
        <property type="entry name" value="TOPRIM_DnaG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002694">
        <property type="entry name" value="Znf_CHC2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10410">
        <property type="entry name" value="DnaB_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08275">
        <property type="entry name" value="Toprim_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01807">
        <property type="entry name" value="zf-CHC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002811">
        <property type="entry name" value="DnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00400">
        <property type="entry name" value="ZnF_CHCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01391">
        <property type="entry name" value="dnaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12 13" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1 12 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2 12 13" id="KW-0639">Primosome</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 12 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 12 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="259"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CHC2-type" evidence="12 14">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="427"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR002811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR002811-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB30637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="588" mass="65270" checksum="A1F58D9BD4B7ED71" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YP6</accession>
    <name>HIS8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidinol-phosphate aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisC</name>
        <name type="ordered locus">Gmet_0385</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512357.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="3HDO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.61 A"/>
        <property type="chains" value="A/B=2-350"/>
    </dbReference>
    <dbReference type="PDBsum" id="3HDO"/>
    <dbReference type="AlphaFoldDB" id="Q39YP6"/>
    <dbReference type="SMR" id="Q39YP6"/>
    <dbReference type="STRING" id="269799.Gmet_0385"/>
    <dbReference type="EnsemblBacteria" id="ABB30628">
        <property type="protein sequence ID" value="ABB30628"/>
        <property type="gene ID" value="Gmet_0385"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0385"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_0_7"/>
    <dbReference type="OMA" id="IWLNANE"/>
    <dbReference type="OrthoDB" id="1248286at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00012"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q39YP6"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000230215" description="Histidinol-phosphate aminotransferase">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="6"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="26"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="51"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="55"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="80"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="83"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="106"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="116"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="127"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="137"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="148"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="176"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="196"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="202"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="211"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="222"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="290"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="turn" evidence="2">
        <location>
            <begin position="323"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="strand" evidence="2">
        <location>
            <begin position="328"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="helix" evidence="2">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="2">
        <source>
            <dbReference type="PDB" id="3HDO"/>
        </source>
    </evidence>
    <sequence length="350" mass="39135" checksum="C6158BFBB5051A99" modified="2005-11-22" version="1">MIPLRQNIASMKGYIPGYQPPDIASWIKLNTNENPYPPSPEVVKAILEELGPDGAALRIYPSASSQKLREVAGELYGFDPSWIIMANGSDEVLNNLIRAFAAEGEEIGYVHPSYSYYGTLAEVQGARVRTFGLTGDFRIAGFPERYEGKVFFLTTPNAPLGPSFPLEYIDELARRCAGMLVLDETYAEFAESNALELVRRHENVVVTRTLSKSYSLAGMRIGLAIARPEVIAALDKIRDHYNLDRLAQAACVAALRDQAYLSECCRRIRETREWFTTELRSIGYDVIPSQGNYLFATPPDRDGKRVYDGLYARKVLVRHFSDPLLAHGMRISIGTREEMEQTLAALKEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YR6</accession>
    <name>Q39YR6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512337.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0365"/>
    <dbReference type="EnsemblBacteria" id="ABB30608">
        <property type="protein sequence ID" value="ABB30608"/>
        <property type="gene ID" value="Gmet_0365"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0365"/>
    <dbReference type="eggNOG" id="ENOG50341M1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1903706_0_0_7"/>
    <dbReference type="OMA" id="AIHMYTP"/>
    <dbReference type="OrthoDB" id="1912481at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="138" mass="15513" checksum="CC0FE636FF1D9028" modified="2005-11-22" version="1">MIERTKNIIANVTVIAVISLLLIGGNTWWRQRTQFQRGEAALAARDYLAAISGYEAAIHMYTPGSSLVENSARRLWDMGGEFERAGDLERALIAYRSLRSSFYAARWLAQPGEEWIEGCDRKIAEILGRQGYPPPAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YY3</accession>
    <name>Q39YY3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrite reductase (cytochrome; ammonia-forming)</fullName>
            <ecNumber evidence="2">1.7.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nrfA-2</name>
        <name evidence="10" type="ordered locus">Gmet_0296</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) = 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:13089"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome c-552 family.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514007.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0296"/>
    <dbReference type="EnsemblBacteria" id="ABB30541">
        <property type="protein sequence ID" value="ABB30541"/>
        <property type="gene ID" value="Gmet_0296"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0296"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035040_1_0_7"/>
    <dbReference type="OMA" id="MHAPDVM"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042279">
        <property type="term" value="F:nitrite reductase (cytochrome, ammonia-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00548">
        <property type="entry name" value="NrfA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003321">
        <property type="entry name" value="Cyt_c552"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30633">
        <property type="entry name" value="PTHR30633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02335">
        <property type="entry name" value="Cytochrom_C552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000243">
        <property type="entry name" value="Cyt_c552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223323" description="Nitrite reductase (cytochrome; ammonia-forming)" evidence="9">
        <location>
            <begin position="20"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="485" mass="53891" checksum="4383672F97DBEF78" modified="2005-11-22" version="1">MLMSNVKRWAAVTAFTAMAAVGTGCAPKKVEQDKSASVADGTIDPAGWKKAYPAQYELWKKTEEPTPTGKSRYKKGYDEDGVFYDKLDEYPFLALLYNGWGFGVEYKEPRGHAYMIHDQFEVDPARLKAGGSCLTCKTPYAPELQQRLGKDYFSKPYKEVHAQIPKEHQMLGVTCIDCHNGSDLSLKISRGFTLGKALEKLGVDRAKLSAQDKRTLVCAQCHVTYAIPKDGNMKSTDVYFPWDGSTYGGITIENIIKKLRSSPANGEWTQGVTGFKLAFIRHPEFELFSNNSPHWQAGVSCADCHMPSTTAGNQKVSDHRVMSPLKNDLKACAQCHTETPDQLRGKVYAIQDRTMSRFIRTGYATATVAKLFEMTNKAEAQGKQIDKTLYAQAKDHYEEAFYRVVFIGAENSVGFHNPTEATRVLEDAAMHAGKADGLLRQALAKAGVTVPAKVDLELEKYVNNRGSKKLMFKPEHEIKDPLAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z97</accession>
    <name>Q39Z97_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512768.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0181"/>
    <dbReference type="EnsemblBacteria" id="ABB30427">
        <property type="protein sequence ID" value="ABB30427"/>
        <property type="gene ID" value="Gmet_0181"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0181"/>
    <dbReference type="eggNOG" id="COG3011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086500_2_1_7"/>
    <dbReference type="OMA" id="MWRAIPL"/>
    <dbReference type="OrthoDB" id="2019103at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007263">
        <property type="entry name" value="DCC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044691">
        <property type="entry name" value="DCC1_Trx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34290">
        <property type="entry name" value="PTHR34290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04134">
        <property type="entry name" value="DCC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="140" mass="15729" checksum="07CE6AF036D847AE" modified="2005-11-22" version="1">MPVPPEFPLSVFYDGSCSVCATEMEAYMRKEHGGRLLFVDISAPSFDPTPYGITLDAFMYQMHAIDRTGRVYLSVEAFWAIWQAFPASTLYGFLGALVMLPGVNLLARAGYRGFARIRKYLPRRRETCAGGSCRIGQREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZA4</accession>
    <name>Q39ZA4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0173</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512761.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0173"/>
    <dbReference type="EnsemblBacteria" id="ABB30420">
        <property type="protein sequence ID" value="ABB30420"/>
        <property type="gene ID" value="Gmet_0173"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0173"/>
    <dbReference type="eggNOG" id="ENOG50338M6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148666_1_0_7"/>
    <dbReference type="OMA" id="LGIGVWC"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="110" mass="12209" checksum="0E41EED6E0E8F8B0" modified="2005-11-22" version="1">MQSIIKALISLVIIIACAKIGKRFPTLGGLIATMPLTSLLVLLWLWSDAPGDYRLMEGYTKGVLWGIIPTVLFFVAALFLFRRQFPLPLVLAASFGVWLTGAAVHQYFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZB5</accession>
    <name>Q39ZB5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512749.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0162"/>
    <dbReference type="EnsemblBacteria" id="ABB30409">
        <property type="protein sequence ID" value="ABB30409"/>
        <property type="gene ID" value="Gmet_0162"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0162"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_9_7"/>
    <dbReference type="OMA" id="MNTPLHW"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="11"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="141" mass="14953" checksum="DF7671746B7FA642" modified="2005-11-22" version="1">MVENVNTKDKHGHTPLIEAAKTGDAETIRDLLNRGADMDARSEKGKTALHYAAANGKAAAIKTLLEAGAEVDPRDMEWHTPLMLAANYGCNECVETLLTAGADPLAKMKLGNTALTYAEANGHPDTLELITKAQRAKAGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZC8</accession>
    <name>Q39ZC8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Ferredoxin-dependent glutamate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">gltS</name>
        <name evidence="16" type="ordered locus">Gmet_0147</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glutamate synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512732.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0147"/>
    <dbReference type="EnsemblBacteria" id="ABB30396">
        <property type="protein sequence ID" value="ABB30396"/>
        <property type="gene ID" value="Gmet_0147"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0147"/>
    <dbReference type="eggNOG" id="COG0067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0069">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_8_2_7"/>
    <dbReference type="OMA" id="LKTGWDV"/>
    <dbReference type="OrthoDB" id="5568at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00717"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015930">
        <property type="term" value="F:glutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006537">
        <property type="term" value="P:glutamate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02808">
        <property type="entry name" value="GltS_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006982">
        <property type="entry name" value="Glu_synth_centr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002932">
        <property type="entry name" value="Glu_synthdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00310">
        <property type="entry name" value="GATase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04898">
        <property type="entry name" value="Glu_syn_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01645">
        <property type="entry name" value="Glu_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0314">Glutamate biosynthesis</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="15">
        <location>
            <begin position="19"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB30396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1510" mass="162840" checksum="0DBC81AF24B7AA41" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZQ6</accession>
    <name>Q39ZQ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclic diguanylate phosphodiesterase, DUF3365 and HAMP domain-containing, heme-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0018</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365617.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0018"/>
    <dbReference type="EnsemblBacteria" id="ABB30268">
        <property type="protein sequence ID" value="ABB30268"/>
        <property type="gene ID" value="Gmet_0018"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0018"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_567125_0_0_7"/>
    <dbReference type="OMA" id="RAWISEH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="237"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="284"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="481" mass="53114" checksum="1A088F240D3E945B" modified="2005-11-22" version="1">MAIRLALARKFLVAVGITVFVTIGILFFFMYEQAQKAIYDHVDRQSTALLQQVVITRAWISEHEGIYIRQAPGVEPNPYLPGSGITDKEGRDYVFHNPALAIRKLSEYAQRKGLYRFHLSSLKPLNPANKPTPFESEALRQFERRGFTASRDGIAGIVRDGDHAAYQRIIPLVVEKSCLTCHLQQGYKVGEVRGGLSVALPLQDAERQIVKARILFALAGAGIMAMVMGTLYYLLRRMVLAPVAHLHGIAGSLSAGNYTARATLTTGDELENLGTAFNTMTDQIISGYQSALKTLAAAVEARDSYTRGHIDRVARYALGIAREMGLPPETVSRVEMAAILHDIGKIGIPDAILRKESSLTPEELEIMQAHSLKGMEIISTSDFFSSVMNAILYHHEFYDGTGYPSGLKGEEIPLVARIITVADSFDAMTTDRPYRRGMPRETALAEIERWKGSQFDPQVVDAFLRGMKRGGLVAKRGTEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>J7LW95</accession>
    <name>J7LW95_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3594</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513221.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFR42810">
        <property type="protein sequence ID" value="AFR42810"/>
        <property type="gene ID" value="Gmet_3594"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3594"/>
    <dbReference type="eggNOG" id="ENOG502ZPAB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2769997_0_0_7"/>
    <dbReference type="OMA" id="GYTFWEC"/>
    <dbReference type="OrthoDB" id="2016443at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="69" mass="8155" checksum="49EDC0F0F0C7FF6F" modified="2012-10-31" version="1">MLLEQLVEQAAQPPKYDWDAYYRWLFSTLAGREVTSFAFWQCPHCLTINFFLPAQRYGKCRGCDLIHLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEP3</accession>
    <name>J9JEP3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514313.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3633"/>
    <dbReference type="EnsemblBacteria" id="AFR42849">
        <property type="protein sequence ID" value="AFR42849"/>
        <property type="gene ID" value="Gmet_3633"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3633"/>
    <dbReference type="HOGENOM" id="CLU_2934939_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="60" mass="7003" checksum="6F4465E0B0EA4C53" modified="2012-10-31" version="1">MLLTDREKLEAAQQALDLSRQSVTELYKADDMILVEHAYDLLQPLVKMEQKLFRLLTVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PP3</accession>
    <name>Q39PP3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_A3576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="3">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="3">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33781.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514716.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3576"/>
    <dbReference type="EnsemblBacteria" id="ABB33781">
        <property type="protein sequence ID" value="ABB33781"/>
        <property type="gene ID" value="Gmet_A3576"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3576"/>
    <dbReference type="HOGENOM" id="CLU_1376429_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33781.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="198" mass="21966" checksum="FA9B93B00374C5DE" modified="2012-10-31" version="2">MGNDKNTAKTLKISKSKSGQSDEKPTYSVDKMRQWLNDNASDTTPDKTPTIWDRLIEIKDDIAAVYPSKMSADKVVKGLKDNGLDITKTTFLTYWQLIKAGHTTRPSTSKKKQPVSEPENSGKNESGFDENPAPVSEEKTGEDLKNSEGEKETYPCPKCKRILTVMRETKPGVHLGQKYISCDADTGGCGYFSYDDGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PT6</accession>
    <name>GRPE_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein GrpE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP-70 cofactor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">grpE</name>
        <name type="ordered locus">Gmet_3533</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GrpE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513689.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39PT6"/>
    <dbReference type="SMR" id="Q39PT6"/>
    <dbReference type="STRING" id="269799.Gmet_3533"/>
    <dbReference type="EnsemblBacteria" id="ABB33738">
        <property type="protein sequence ID" value="ABB33738"/>
        <property type="gene ID" value="Gmet_3533"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3533"/>
    <dbReference type="eggNOG" id="COG0576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057217_6_0_7"/>
    <dbReference type="OMA" id="YAYEKIA"/>
    <dbReference type="OrthoDB" id="1906715at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_coiled_coil"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="PTHR21237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="SSF51064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="SSF58014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_1000137573" description="Protein GrpE">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="189" mass="20763" checksum="B720DFA7B1E07A0A" modified="2005-11-22" version="1">MDKKKHGSHAGAHHTDEPAAETVAPAAEGAPAAADRVKELEEALAAKEAEAAANWDKFVRERADLENYRKRTQKEKEELLKYGNESLIVEILPVVDNMERALDHSDDDSASAVIEGVRMTLNMLLSTLKKFGVTVVEAEKGTPFDPAVHQAMCQVENTDVPANSVVEIFQKGYLLNERLIRPAMVSVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PZ0</accession>
    <name>Q39PZ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response receiver-modulated cyclic diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3476</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33684.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513926.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3476"/>
    <dbReference type="EnsemblBacteria" id="ABB33684">
        <property type="protein sequence ID" value="ABB33684"/>
        <property type="gene ID" value="Gmet_3476"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3476"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_10_7"/>
    <dbReference type="OMA" id="LILERQM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="11"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="4">
        <location>
            <begin position="182"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="136"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33684.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="436" mass="49362" checksum="70AC52673B452260" modified="2012-10-31" version="2">MYELPETAPVRVLFVDDEENMLKSLSRVFMDEEFEVITAPSAREGLRILMETEDVGVIVSDQRMPEITGVQFLAQVREMFPETLRIMLTGYADISATVDAINRGGAYRYITKPWNDEELVQIIRDAVNQYRLVQENRRLTEIVNKQNEELKEWNENLKVRVLEQTTEIRKKHENLKELNERLRSNFKDTVTAFSRLIELGGKKRHAETVATLAMNIAQAMGVSAGEVETVHNAALLHDIGELGIADAILKKDLSEMTPGELREYMLHAVRGQTAIDAIEELTPAGVLIRHHHEHYDGSGYPDGLRGEAIPLGSRIIAIADFLDRAIQKLHGYTAIDYGLRSVAAELGKKLDPSLYESLRKFAKHVYYVKETDTRKLGEVEVGIAELFVGQVLSRDIYSGTGLLLLNRGVRLDVVKIEAIRRYYRLDPPPHGVFVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PZ4</accession>
    <name>Q39PZ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513922.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3472"/>
    <dbReference type="EnsemblBacteria" id="ABB33680">
        <property type="protein sequence ID" value="ABB33680"/>
        <property type="gene ID" value="Gmet_3472"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3472"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="SDERMAR"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="187" mass="21291" checksum="CF27F6C6F41A7FC7" modified="2005-11-22" version="1">MKKTLLLVDDEPFVINSLRRALADEPYEILTAGSGQEGLALFAEHRVGVVVSDEKMPGMGGAEFLAAVRERYPETIRIMLTGHASIDATMRAVNQGEIYRFFTKPWDDLELRFALRSAFDRLVLEEDNRRLLRTVKRQSQELSALEQKYPGITDVEKDADGALVLPEISVEDINNFIERCNREYQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q08</accession>
    <name>Q39Q08_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513908.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3457"/>
    <dbReference type="EnsemblBacteria" id="ABB33666">
        <property type="protein sequence ID" value="ABB33666"/>
        <property type="gene ID" value="Gmet_3457"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3457"/>
    <dbReference type="eggNOG" id="ENOG5032WMF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183665_0_0_7"/>
    <dbReference type="OMA" id="EDLWIAH"/>
    <dbReference type="OrthoDB" id="1762734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223129" evidence="1">
        <location>
            <begin position="23"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="227" mass="24642" checksum="E5E3623D35BC36AE" modified="2005-11-22" version="1">MRHGIYNLILILLLLAPLPAQAIPAITCHCFTDRSYDPASPTVADPYFLATTQNSFFATAFNVEKKTIVMKKQRGTSADDLWVAYWIASKSPASPESLLEAKKSRESWKDVVASQGISPGVLGPRFSGTLAAKAPAARLAGAVVDELLLRYRLLNDGELAGMHKDGASNQELIIASVIARKTKQPAPQLYHEVKSGKKSWGALLQNAKIDATDMQGEISDLLKAQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q81</accession>
    <name>Q39Q81_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Futalosine hydrolase</fullName>
            <shortName evidence="1">FL hydrolase</shortName>
            <ecNumber evidence="1">3.2.2.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Futalosine nucleosidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Menaquinone biosynthetic enzyme MqnB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 3" type="primary">mqnB</name>
        <name evidence="3" type="ordered locus">Gmet_3381</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of futalosine (FL) to dehypoxanthine futalosine (DHFL) and hypoxanthine, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>futalosine + H2O = dehypoxanthine futalosine + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:25904"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:58863"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="EC" id="3.2.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP/UDP phosphorylase family. Futalosine hydrolase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.26" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512607.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3381"/>
    <dbReference type="EnsemblBacteria" id="ABB33593">
        <property type="protein sequence ID" value="ABB33593"/>
        <property type="gene ID" value="Gmet_3381"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3381"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031248_3_1_7"/>
    <dbReference type="OMA" id="MEGYGVA"/>
    <dbReference type="OrthoDB" id="1860206at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00991">
        <property type="entry name" value="MqnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019963">
        <property type="entry name" value="FL_hydrolase_MqnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03664">
        <property type="entry name" value="fut_nucase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="2">
        <location>
            <begin position="4"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="243" mass="25845" checksum="5CB8C3607D13E5EB" modified="2005-11-22" version="1">MDSIIIAAATSLELSLLVRSIGAREVRRKKGFSDTYRGKVGGTTVLLAVTGIGKANTASALTALLERYTPRLLIDTGCAGAYGGGGLAVGDLAVASTEVYGDEGILTPSGWESLEIIGIPQLERGGRRFFNEFPLALLPAERAVQLGAALGVPVRRGRFVTVSTCSGTTARGNALARRFNAICENMEGAVAAHLALRYGIDCLELRGISNMVEDRDLSGWNIPLAVERAQRFILKFLETCNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q91</accession>
    <name>Q39Q91_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Type II secretion system protein K</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gspK</name>
        <name evidence="12" type="ordered locus">Gmet_3371</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the GSP K family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512597.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3371"/>
    <dbReference type="EnsemblBacteria" id="ABB33583">
        <property type="protein sequence ID" value="ABB33583"/>
        <property type="gene ID" value="Gmet_3371"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3371"/>
    <dbReference type="eggNOG" id="COG3156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057294_1_2_7"/>
    <dbReference type="OMA" id="AYWYSIG"/>
    <dbReference type="OrthoDB" id="1516369at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005628">
        <property type="entry name" value="GspK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038072">
        <property type="entry name" value="GspK_central_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38831">
        <property type="entry name" value="PTHR38831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03934">
        <property type="entry name" value="T2SSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002786">
        <property type="entry name" value="XcpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158544">
        <property type="entry name" value="SSF158544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5 11" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR002786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="299" mass="32897" checksum="94763446E5822E46" modified="2005-11-22" version="1">MRTLRQEQGFALVLTLVVTALLVAVAVEFIHGVYVDTSLQRNFVNLQQASLMADSGVKGGIALIRSLRQSGDNTALLQVLEIPQELEDEKGKVSVTIEEENGKLNLNAVSEFHDQARRRLLRLQGFPEGISDAVADWVDADQDPRPDGAETPYYQALSAPYLPRNGPMQTFGELGLVRGFTPAIVQKLSPYATVYGADWAIDINTAPLPVLMALHDDMTEELARAIIERRRQTPFASTGELATVPGMDRIANSPGMQLGVRGSTYRLVSRATVGEAVRIVEAVVGLEGMQPQYLYWREY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q95</accession>
    <name>Q39Q95_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system core protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">gspG</name>
        <name evidence="12" type="ordered locus">Gmet_3367</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP G family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512593.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3367"/>
    <dbReference type="EnsemblBacteria" id="ABB33579">
        <property type="protein sequence ID" value="ABB33579"/>
        <property type="gene ID" value="Gmet_3367"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3367"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_2_1_7"/>
    <dbReference type="OMA" id="PWRNDYL"/>
    <dbReference type="OrthoDB" id="2044924at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013545">
        <property type="entry name" value="T2SS_protein-GspG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010054">
        <property type="entry name" value="Type2_sec_GspG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08334">
        <property type="entry name" value="T2SSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01710">
        <property type="entry name" value="typeII_sec_gspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSG" evidence="11">
        <location>
            <begin position="33"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="15918" checksum="04011C53973E2510" modified="2005-11-22" version="1">MNRKPMNNRGFTLIEIMVVIAILALLAALVAPKIIGRSDDAKIADAKVQIKNMETALKLYKLDNGVFPSTEQGLAALVAKPAVGQIPKNYKAEGYLESKKVPKDPWGNDFAYLSPGEHGDYDLYSLGADGVKGGEGKNADIESWNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QH0</accession>
    <name>Q39QH0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366176.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3291"/>
    <dbReference type="EnsemblBacteria" id="ABB33504">
        <property type="protein sequence ID" value="ABB33504"/>
        <property type="gene ID" value="Gmet_3291"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3291"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_7"/>
    <dbReference type="OMA" id="LNWMRAM"/>
    <dbReference type="OrthoDB" id="1114675at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="263" mass="28279" checksum="08C219BB22897671" modified="2005-11-22" version="1">MTTETILTQIDDRGVATLTMNRPELHNAFDDLLIAALTAELRRLEADDSVRVVILAASGRSFSAGADLSWMRRMADYTREENLTDAQVLAELMRTLATLKKPTIAQVQGAAFGGGVGLVACCDVAIASRRATFCLSEVKLGLIPAVISPYVVEALGPRAARRYFQSAEIFDAAEARGLGLVHEVTTEEELPAAVERLAATLLLNGPRAMAAAKELVARVASGPIDEAMIRDTAERIADTRASAEGKEGLSAFLEKRKPRWVKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QK1</accession>
    <name>PURA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenylosuccinate synthetase</fullName>
            <shortName evidence="1">AMPSase</shortName>
            <shortName evidence="1">AdSS</shortName>
            <ecNumber evidence="1">6.3.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IMP--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purA</name>
        <name type="ordered locus">Gmet_3260</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + IMP + L-aspartate = GDP + 2 H(+) + N(6)-(1,2-dicarboxyethyl)-AMP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15753"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="6.3.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adenylosuccinate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512698.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QK1"/>
    <dbReference type="SMR" id="Q39QK1"/>
    <dbReference type="STRING" id="269799.Gmet_3260"/>
    <dbReference type="EnsemblBacteria" id="ABB33473">
        <property type="protein sequence ID" value="ABB33473"/>
        <property type="gene ID" value="Gmet_3260"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3260"/>
    <dbReference type="eggNOG" id="COG0104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029848_0_0_7"/>
    <dbReference type="OMA" id="FHHAKPI"/>
    <dbReference type="OrthoDB" id="232152at2"/>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00335"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03108">
        <property type="entry name" value="AdSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00011">
        <property type="entry name" value="Adenylosucc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018220">
        <property type="entry name" value="Adenylosuccin_syn_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033128">
        <property type="entry name" value="Adenylosuccin_syn_Lys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042110">
        <property type="entry name" value="Adenylosuccinate_synth_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042111">
        <property type="entry name" value="Adenylosuccinate_synth_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="PTHR11846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00184">
        <property type="entry name" value="purA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01266">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00513">
        <property type="entry name" value="ADENYLOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000000828" description="Adenylosuccinate synthetase">
        <location>
            <begin position="1"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="41"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="38"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="300"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="332"/>
            <end position="334"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="414"/>
            <end position="416"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00011"/>
        </source>
    </evidence>
    <sequence length="430" mass="47280" checksum="A791E6EA4C24E4F8" modified="2005-11-22" version="1">MANVVVVGAQWGDEGKGKVVDIYTEHADDVVRYQGGNNAGHTLVVNGEKTVLHLIPSGILHKGKRCIIGNGVVLDPEVFIMEINRLKEKGRLQDDSALLVSESVHIIMPYHKQIDLAREAKSGDKKIGTTGRGIGPTYEDKIGRRGIRLMDLLDPEIFARKLRENLEEKNFILEKLLGEKPLSFDEIHKTYSGYADILRKYVANTSLILCKDIAAGKKLLFEGAQGTLLDVDHGTYPFVTSSSTCAGGACTGTGVGPRDIHEIIGISKAYVTRVGSGPFPTELLDADGEQLRQTGGEFGATTGRPRRCGWFDAMVVRFAVRVNGLTGVALTKLDVLNDFDTIKICTGYTYEGKPVEDLPANLAVFEKCQPVYEEMPGWKSDIRGVRRFEDLPEKARLYVHRLQELISCPIVLVSIGPGRDETITIRNPFA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QN3</accession>
    <name>UVRC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UvrABC system protein C</fullName>
            <shortName evidence="1">Protein UvrC</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Excinuclease ABC subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uvrC</name>
        <name type="ordered locus">Gmet_3228</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with UvrB in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UvrC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512667.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QN3"/>
    <dbReference type="SMR" id="Q39QN3"/>
    <dbReference type="STRING" id="269799.Gmet_3228"/>
    <dbReference type="EnsemblBacteria" id="ABB33441">
        <property type="protein sequence ID" value="ABB33441"/>
        <property type="gene ID" value="Gmet_3228"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3228"/>
    <dbReference type="eggNOG" id="COG0322">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014841_3_2_7"/>
    <dbReference type="OMA" id="HIECFDN"/>
    <dbReference type="OrthoDB" id="1036075at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00203">
        <property type="entry name" value="UvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004791">
        <property type="entry name" value="UvrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001162">
        <property type="entry name" value="UvrC_RNase_H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038476">
        <property type="entry name" value="UvrC_RNase_H_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08459">
        <property type="entry name" value="UvrC_HhH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00465">
        <property type="entry name" value="GIYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="SSF82771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00194">
        <property type="entry name" value="uvrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50165">
        <property type="entry name" value="UVRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0228">DNA excision</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0267">Excision nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000264896" description="UvrABC system protein C">
        <location>
            <begin position="1"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="12"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="1">
        <location>
            <begin position="201"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00203"/>
        </source>
    </evidence>
    <sequence length="614" mass="69719" checksum="F951692DE125D2B9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QT6</accession>
    <name>GLGA2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycogen synthase 2</fullName>
            <ecNumber evidence="1">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Starch [bacterial glycogen] synthase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgA2</name>
        <name type="ordered locus">Gmet_3175</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513892.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QT6"/>
    <dbReference type="SMR" id="Q39QT6"/>
    <dbReference type="STRING" id="269799.Gmet_3175"/>
    <dbReference type="CAZy" id="GT5">
        <property type="family name" value="Glycosyltransferase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33388">
        <property type="protein sequence ID" value="ABB33388"/>
        <property type="gene ID" value="Gmet_3175"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3175"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_2_7"/>
    <dbReference type="OMA" id="TWCPWYM"/>
    <dbReference type="OrthoDB" id="83240at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000230242" description="Glycogen synthase 2">
        <location>
            <begin position="1"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <sequence length="484" mass="53848" checksum="949EE76DFB6096BD" modified="2005-11-22" version="1">MKILQVASEVAPLAKTGGLADVVAALPKELRRMGHDVRVAIPFYKEVSSGNLPVRKARKSAEVALGGELHKGYLRQTALGEVPVYLVENRDLFGRDHLYGPPEGDYPDNPLRFAFFCRSVLQFLKRMDFRPDVIHCHDWQSALIPIILKYELGHDPFFNRTAVIFTIHNLAYQGVFPADALAQTGLDPSLFSVDRIEFYGRINLLKGAILAADAITTVSETYCHEILSPGQGCGLEGVLERRQADLAGILNGLDSEEWNPSLDRRIFRNYSSKSLAGKGADKRELQRELGLKAGASIPIIGMVGRIVEQKGIDLVIDLLPRFAAEELQLVILGTGDLRLMHQLHEFRNKGVKNVSINLGFKEPLAPKIYAGCDMFLMPSRFEPCGLSQLIALSYGTVPIVRRTGGLADTVIDVTANPREGNGFSFTEFSADACWDAVQRALAAYRDREGWRKIMRRGMLRDVSWRSAAGKYEELYRTCADNRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QZ0</accession>
    <name>Q39QZ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514295.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3120"/>
    <dbReference type="EnsemblBacteria" id="ABB33334">
        <property type="protein sequence ID" value="ABB33334"/>
        <property type="gene ID" value="Gmet_3120"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3120"/>
    <dbReference type="HOGENOM" id="CLU_2450403_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="89" mass="9503" checksum="3345F04A91971588" modified="2005-11-22" version="1">MRHGCPGVFPRPVREHVNKAGATVRGMEEVLRTIEESADAANLLAIEMAIGGWETAPVRQCDDQLAAAADRSVRATADMACLLRSSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QZ1</accession>
    <name>Q39QZ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver CheY associated with MCPs of classes 40H and 40+24H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY64H-1</name>
        <name evidence="3" type="ordered locus">Gmet_3119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514294.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3119"/>
    <dbReference type="EnsemblBacteria" id="ABB33333">
        <property type="protein sequence ID" value="ABB33333"/>
        <property type="gene ID" value="Gmet_3119"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3119"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_12_7"/>
    <dbReference type="OMA" id="IVAAKFQ"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="120" mass="12798" checksum="EF18691FF3F7EE8D" modified="2005-11-22" version="1">MANVLIVDDSSTMRKIISRSLRQAGLPVDEIFEGGDGIEGLNVLAGKSVDLILSDINMPNMDGLEFIKQARANGCKAPIVMITTEGGEDILKQALENGASDSIKKPFTPDQLNEKLGGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RB1</accession>
    <name>Q39RB1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2998</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514489.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2998"/>
    <dbReference type="EnsemblBacteria" id="ABB33213">
        <property type="protein sequence ID" value="ABB33213"/>
        <property type="gene ID" value="Gmet_2998"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2998"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349093_0_0_7"/>
    <dbReference type="OMA" id="LQWTLSQ"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="203"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="341"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="597"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="807" mass="89265" checksum="8A319B8ED78E418F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RD2</accession>
    <name>Q39RD2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366131.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2977"/>
    <dbReference type="EnsemblBacteria" id="ABB33192">
        <property type="protein sequence ID" value="ABB33192"/>
        <property type="gene ID" value="Gmet_2977"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2977"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033863_21_3_7"/>
    <dbReference type="OMA" id="AYTLQIV"/>
    <dbReference type="OrthoDB" id="1425840at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="19"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="153"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="309" mass="33995" checksum="4142AB222853F950" modified="2005-11-22" version="1">MTHTRESAPMPQGKVTAILVFTTVLWGGSFLFNKIGMREIPPIQFFFFRFALAALLMGIICIPRLSRLNRDIVRRGAMVGVALAAVNLTFVLGVSGTTISRAGYLNNLFVLFIPLISFLIWRERLDRITFAGVFLAVAGLWELASGGAEGFNRGDLLSTVCAVFIAIHIITVSRVLRDEDVYLVTFVQFSTVALAGAAITLAMPWPAFTIGAAGGWSLAYCAIFPTVICFTLQNAFQRFTTPTKAGLIYTLDPVWSMLAGVFILGERLTPRELVGCMLILVAVAGPLLGRLYLEQRHRRLYHLDDVEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RD3</accession>
    <name>Q39RD3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidyl-tRNA hydrolase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2976</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514467.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2976"/>
    <dbReference type="EnsemblBacteria" id="ABB33191">
        <property type="protein sequence ID" value="ABB33191"/>
        <property type="gene ID" value="Gmet_2976"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2976"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_4_3_7"/>
    <dbReference type="OMA" id="AVNKTNN"/>
    <dbReference type="OrthoDB" id="2047548at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="23"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="121" mass="13974" checksum="332138FA3142D995" modified="2005-11-22" version="1">MATPTFAVSEEKNRWLREKMTELGVAEADLEESFVRSSGAGGQHVNKTATCVQIKHRPTGIEVKCMKDRSQSVNRFLARREILVRIERLQKGESFRDPKAEKLKKQKARRKRRASGKYEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RD6</accession>
    <name>Q39RD6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin, RelE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512906.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2973"/>
    <dbReference type="EnsemblBacteria" id="ABB33188">
        <property type="protein sequence ID" value="ABB33188"/>
        <property type="gene ID" value="Gmet_2973"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2973"/>
    <dbReference type="eggNOG" id="COG3549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155111_1_1_7"/>
    <dbReference type="OMA" id="INDQWRL"/>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007711">
        <property type="entry name" value="HigB-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40266">
        <property type="entry name" value="PTHR40266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05015">
        <property type="entry name" value="HigB-like_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="92" mass="10890" checksum="97AAC889CBE1C3C4" modified="2005-11-22" version="1">MIKSFRCKDTQALFEGKCPRRFKAFSTVAERKLQMLDDAHSPEDLRSPPGNRLEVLRGDRKGQWSIRINDQWRLCFRFEDGNAFDVEIVDYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RG1</accession>
    <name>Q39RG1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2945</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512881.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2945"/>
    <dbReference type="EnsemblBacteria" id="ABB33163">
        <property type="protein sequence ID" value="ABB33163"/>
        <property type="gene ID" value="Gmet_2945"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2945"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1765416_0_0_7"/>
    <dbReference type="OMA" id="YLARTCF"/>
    <dbReference type="OrthoDB" id="1725187at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="16828" checksum="CC64865E2F8B718D" modified="2005-11-22" version="1">METSRVEEWFERGVEALGHDQVYLARSCFEHVARVNQHPAASSYLALCQAKTRGKFSDAIALARESIAREPHNPLLYQNLGRIYQLAGMRMDAVEVLREGVRRGAGEEAVAELNRIGTRKQPPFRRLHRNHPLNKYVGKLLARLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RI5</accession>
    <name>Q39RI5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2921</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366123.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2921"/>
    <dbReference type="EnsemblBacteria" id="ABB33139">
        <property type="protein sequence ID" value="ABB33139"/>
        <property type="gene ID" value="Gmet_2921"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2921"/>
    <dbReference type="eggNOG" id="ENOG5032SV1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135474_1_0_7"/>
    <dbReference type="OMA" id="SGTNGCD"/>
    <dbReference type="OrthoDB" id="1932693at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021383">
        <property type="entry name" value="DUF3015"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11220">
        <property type="entry name" value="DUF3015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223020" evidence="1">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="154" mass="16069" checksum="5C85CCD1EAB7250D" modified="2005-11-22" version="1">MKRALLAVAITVVTAASAFAASGKANTGCGLGTVLWKGRADSSVFSQALQATTNQTFGTQTFGITSGTLECGTPGKVVQNERLNHFVRANMDNLARDIAQGRGESLDAFAELLQVPADKRPGFYAALQSNFASVFTSENVVVAEVIDNAVALAN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RP0</accession>
    <name>RL19_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplS</name>
        <name type="ordered locus">Gmet_2866</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514597.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RP0"/>
    <dbReference type="SMR" id="Q39RP0"/>
    <dbReference type="STRING" id="269799.Gmet_2866"/>
    <dbReference type="EnsemblBacteria" id="ABB33084">
        <property type="protein sequence ID" value="ABB33084"/>
        <property type="gene ID" value="Gmet_2866"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2866"/>
    <dbReference type="eggNOG" id="COG0335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103507_2_1_7"/>
    <dbReference type="OMA" id="TITVYYE"/>
    <dbReference type="OrthoDB" id="1698718at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00402">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="L19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_L19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018257">
        <property type="entry name" value="Ribosomal_L19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="PTHR15680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002191">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00061">
        <property type="entry name" value="RIBOSOMALL19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01024">
        <property type="entry name" value="rplS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01015">
        <property type="entry name" value="RIBOSOMAL_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000226849" description="50S ribosomal protein L19">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00402"/>
        </source>
    </evidence>
    <sequence length="118" mass="13418" checksum="EE935DA2CB189794" modified="2005-11-22" version="1">MNTIDMLELEQMKKNIPPFKPGDTVKVHVKIVEGDKSRIQAFQGVVIARQNGGIRESFTVRKISNGIGVERVFPLHSPSLDAIEVITRGHVRRAKLYYLRKLRGKAARIREKKYVAAH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RR0</accession>
    <name>PTH_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidyl-tRNA hydrolase</fullName>
            <shortName evidence="1">PTH</shortName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pth</name>
        <name type="ordered locus">Gmet_2846</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = a tRNA + an N-acyl-L-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PTH family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514570.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RR0"/>
    <dbReference type="SMR" id="Q39RR0"/>
    <dbReference type="STRING" id="269799.Gmet_2846"/>
    <dbReference type="EnsemblBacteria" id="ABB33064">
        <property type="protein sequence ID" value="ABB33064"/>
        <property type="gene ID" value="Gmet_2846"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2846"/>
    <dbReference type="eggNOG" id="COG0193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062456_4_1_7"/>
    <dbReference type="OMA" id="HVLSKFH"/>
    <dbReference type="OrthoDB" id="1676462at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:aminoacyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00462">
        <property type="entry name" value="PTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00083">
        <property type="entry name" value="Pept_tRNA_hydro_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PTHR17224"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="SSF53178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01195">
        <property type="entry name" value="PEPT_TRNA_HYDROL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264042" description="Peptidyl-tRNA hydrolase">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00083"/>
        </source>
    </evidence>
    <sequence length="194" mass="20947" checksum="04BE40F9155697CE" modified="2005-11-22" version="1">MATRLIIGLGNPGPKYQWTRHNAGFMVLDHLSRVMGTSVAKKSFSGLYGEGSWHGDRLLLLKPQTFMNLSGRSAAEALRFHKLTLSDLIVIHDDLDIPFGRVKLKEGGGHGGHNGLRSLMQELGGGGFVRIRIGVGRPLRGDAADYVLANFSSAEMAGLPALLDGVVDLLGELVRNGLPRTMSLYNNKDFLPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RS6</accession>
    <name>Q39RS6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513973.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2830"/>
    <dbReference type="EnsemblBacteria" id="ABB33048">
        <property type="protein sequence ID" value="ABB33048"/>
        <property type="gene ID" value="Gmet_2830"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2830"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056435_5_3_7"/>
    <dbReference type="OMA" id="VVTNYLW"/>
    <dbReference type="OrthoDB" id="2049098at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_25" evidence="1">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="190" mass="21531" checksum="D46ABBC678D47383" modified="2005-11-22" version="1">MNDDSERWDERYRSEEFLLGEKPSRFLAERIEEVKCLCPGRKALDIACGEGRNSIFLARHGYSVTGLDISPVAVEKARRWAGREGLACDFRLADLETYAFDERFDLIINFNFLLRDLIPQEVAALTPGGVVIFDTILESPTAPVPHRKEFLLQPGELARFFAPYPGTILFCGEYPDSATPTAKLIYRHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RV2</accession>
    <name>Q39RV2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytokinin riboside 5'-monophosphate phosphoribohydrolase</fullName>
            <ecNumber evidence="2">3.2.2.n1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + H2O = adenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:20129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.2.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LOG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.n1" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514680.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2804"/>
    <dbReference type="EnsemblBacteria" id="ABB33022">
        <property type="protein sequence ID" value="ABB33022"/>
        <property type="gene ID" value="Gmet_2804"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2804"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_4_2_7"/>
    <dbReference type="OMA" id="HQKPIGL"/>
    <dbReference type="OrthoDB" id="1255127at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008714">
        <property type="term" value="F:AMP nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0203">Cytokinin biosynthesis</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="193" mass="20829" checksum="97D39CAFA3F349B9" modified="2005-11-22" version="1">MKRICVFCGSSPGRNPVYRAAAEAMGRLLAREGIGLVYGGSSIGLMTAAADAALAAGGEVIGVIPRCLEAKEIAHPGLSALHVVETMHERKALMAGLADGFVALPGGMGTFDEFFEVVTWAQLGIHAKPYGLLNVAGYYDRLTAFLDHTVAEGFVKKELREMIVVEERPDALLERFRAYRPPVAEKWLDLGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RW7</accession>
    <name>Q39RW7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511673.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2789"/>
    <dbReference type="EnsemblBacteria" id="ABB33007">
        <property type="protein sequence ID" value="ABB33007"/>
        <property type="gene ID" value="Gmet_2789"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2789"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="DNPMNME"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="122" mass="13510" checksum="FD09DCE863E24267" modified="2005-11-22" version="1">MNNKILIIEDNEQNLYLLSFILEKHGYEVFAAMDGFEGIALADSVRPTLILLDIQLPEMDGYDVARKLRANPSLADVPIVAVTSYAMAGDREKALIAGCSGYIEKPINPDTFMQQVKEHLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RY3</accession>
    <name>Q39RY3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, UPF0118 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2773</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511688.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2773"/>
    <dbReference type="EnsemblBacteria" id="ABB32991">
        <property type="protein sequence ID" value="ABB32991"/>
        <property type="gene ID" value="Gmet_2773"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2773"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_8_1_7"/>
    <dbReference type="OMA" id="QEDPTDA"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="350" mass="38576" checksum="6BD53B8DBA335929" modified="2005-11-22" version="1">MRPRDAAHIAWFLAATLGVVLLAGHVARHSLSAILTSLVIAYLLNPFMKCLERKGLGRIPAIAILYLCIAVIMFFSLFALIPYLNHQLEAFPRAVPRYVQNLERVMEVWKARLSPYYGSDEGTWLIASAQDSLKKLALDVSGKGYQELKAALFGLFNLVLAPILVFFMLSSKQFFKDLILRFVPHRERHSFREVGGRIKDSLERFVMAQFFDCLLVGILSALALYLLGIEFPLLNGFVAGFASVVPYVGVMVAVIPPALMGYAETGDLMIIPKVCAAYFVINVIIEGNLIKPLLMRGTLRLNPLAVVFALMALGELMGFWGVVLAVPVAAVVKICAVELKGYLVGGERDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S43</accession>
    <name>Q39S43_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periplasmic carboxy-terminal processing protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ctpA-1</name>
        <name evidence="6" type="ordered locus">Gmet_2713</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the peptidase S41A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511747.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2713"/>
    <dbReference type="MEROPS" id="S41.004"/>
    <dbReference type="EnsemblBacteria" id="ABB32931">
        <property type="protein sequence ID" value="ABB32931"/>
        <property type="gene ID" value="Gmet_2713"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2713"/>
    <dbReference type="eggNOG" id="COG0793">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017295_1_1_7"/>
    <dbReference type="OMA" id="NHQDWDM"/>
    <dbReference type="OrthoDB" id="1646508at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07560">
        <property type="entry name" value="Peptidase_S41_CPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004447">
        <property type="entry name" value="Peptidase_S41A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005151">
        <property type="entry name" value="Tail-specific_protease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03572">
        <property type="entry name" value="Peptidase_S41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00245">
        <property type="entry name" value="TSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00225">
        <property type="entry name" value="prc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="PDZ" evidence="5">
        <location>
            <begin position="93"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="380"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="404"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="457" mass="49515" checksum="F5AC3143EB36A0F4" modified="2005-11-22" version="1">MVQTRTKITLGLMAVIACLAFGGATLWRLAATAPDREGVASLKLLAEVLRQVEENYVERVDRKKLLEGAVNGMLAALDPHSAYLPPEPFSEMKVEISGSFGGLGIEIALKEGKLTVISPIEDTPAWRAGIKAGDHIWKIDGTPTRDLTIVQAVKKMRGERGTKVTLTILRNGETEPREFPLVRDIIQTKSLKARSLEPGYGYVRISHFQERTGEDFANALRNLRAENGGTLKGLVLDLRNNPGGLLEVAVAVAGRFVGERLDNGLIVYTEGREEFAKRRFSATVGEKEPPYPLVVLINSGSASASEIVAGALQDYGRAVIMGTPSFGKGSVQTVIPMKDGAGLKLTTALYYTPKGRSIQARGIIPDVIVENAELKSVTKDRREDFHEKDLDNHLGGGKDAVPAKGPIEKNEESGKKGQPARHAVGPEDDAKKDFQLARALDLLKSWEVLQKVAGGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S73</accession>
    <name>Q39S73_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adenosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366082.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2683"/>
    <dbReference type="DNASU" id="3740106"/>
    <dbReference type="EnsemblBacteria" id="ABB32901">
        <property type="protein sequence ID" value="ABB32901"/>
        <property type="gene ID" value="Gmet_2683"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2683"/>
    <dbReference type="eggNOG" id="COG0524">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065902_2_1_7"/>
    <dbReference type="OMA" id="DMNTRDT"/>
    <dbReference type="OrthoDB" id="1604782at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PfkB" evidence="3">
        <location>
            <begin position="16"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="305" mass="33780" checksum="03D259F438412886" modified="2005-11-22" version="1">MGILVVGSVAFDSVETPFGRVENVLGGSATYFSTSASFFTDVSLVAVVGEDFPQEHVEFLNSRNIDLRGLAREGGKTFHWKGKYGYDLNEAQTLETHLNVFESFRPQIPAAYRDAEFLFLANIDPELQMEVLSQVEKPRVIACDTMNFWISSKPEALKAVIAKVDIFIINEGEARQFTQEANLTKAARKILAMGVKTLVIKRGEYGVLMFTDHSVFAAPAFPLEDVFDPTGAGDTFAGGFMGYLANTGDTSETGIRQAIIFGSVMASFNVEDFSLNRLKRLEYREIEDRYRSFKALTHFEGLAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S84</accession>
    <name>Q39S84_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Zn_dep_PLPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32890.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511789.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2672"/>
    <dbReference type="EnsemblBacteria" id="ABB32890">
        <property type="protein sequence ID" value="ABB32890"/>
        <property type="gene ID" value="Gmet_2672"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2672"/>
    <dbReference type="eggNOG" id="ENOG502ZCJY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073805_0_0_7"/>
    <dbReference type="OMA" id="VAHNYYV"/>
    <dbReference type="OrthoDB" id="863455at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029002">
        <property type="entry name" value="PLPC/GPLD1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00882">
        <property type="entry name" value="Zn_dep_PLPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn_dep_PLPC" evidence="1">
        <location>
            <begin position="29"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32890.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="305" mass="34678" checksum="7A3A21242DFBC8B8" modified="2012-10-31" version="2">MIPMPILPIFLLIILFVPANAFAWGAGIHLQLGTAVINNLQAVSPAVAAVVGAFPHDFLYGCIAADITLGKKFTHYLQHCHRWRIGMKVLEYAWNPPQKACAYGYLAHLAADTVAHNYYVPAKTMESFSTLTLKHAYWEMRLETYVDQEIWETGKKVATENYKANDALLRNVLSDTLFSFGTNKRIFNSILLVSRLEKWQQVLKTLSDTSRYTLEEDDRSEYLDLAEEAVFDFLNRLEESRYFQADPTGERALATAEAVRKNLRLLYNAGKITKEDAVAQVDAMRARLREAIWEPEKLLQILSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SA9</accession>
    <name>Q39SA9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511815.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2647"/>
    <dbReference type="EnsemblBacteria" id="ABB32865">
        <property type="protein sequence ID" value="ABB32865"/>
        <property type="gene ID" value="Gmet_2647"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2647"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050993_3_2_7"/>
    <dbReference type="OMA" id="CETEFIP"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="209" mass="22336" checksum="FD9EFA6BE733792E" modified="2005-11-22" version="1">MKVLGISCSPRPGQTTDRLVQEVLNNIEAPTEFVSLSGRRIGPCLGCLGCVADNVCKVRDDMGELRPLIVEADALVIGAPNYFGMLNGLAHCFLERLYQFRHQEGGALHGKLGVAVGVGSAMPDSAVRDIEKFFSFSRIEPVGNVTAIGPASCFNCGHGEECREGAIHRVFGPGTKITADLTPNLSKQPDSLTAARTLGEKLTQRLKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SF0</accession>
    <name>Q39SF0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2605</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511856.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32824">
        <property type="protein sequence ID" value="ABB32824"/>
        <property type="gene ID" value="Gmet_2605"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2605"/>
    <dbReference type="HOGENOM" id="CLU_194458_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223211" evidence="2">
        <location>
            <begin position="24"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="89" mass="8970" checksum="890B9B46B62B27DA" modified="2005-11-22" version="1">MKKILSSITAALVAIAFAGIAFAAEPAAKAAPALPAGHPPVKVEEKKGVEKKAKKATKAKKAVKQEEAKPGATPATPATPATPAVPHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SL1</accession>
    <name>Q39SL1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Lon protease</fullName>
            <ecNumber evidence="6 7">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">lon-1</name>
        <name evidence="6" type="synonym">lon</name>
        <name evidence="14" type="ordered locus">Gmet_2544</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 10">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7 10 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="6 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513490.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2544"/>
    <dbReference type="MEROPS" id="S16.001"/>
    <dbReference type="EnsemblBacteria" id="ABB32763">
        <property type="protein sequence ID" value="ABB32763"/>
        <property type="gene ID" value="Gmet_2544"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2544"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_7"/>
    <dbReference type="OMA" id="DVMKMID"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="13">
        <location>
            <begin position="13"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="12">
        <location>
            <begin position="592"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8 10">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8 10">
        <location>
            <position position="722"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <begin position="356"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="774" mass="86179" checksum="61E2D799AF1EA674" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SP8</accession>
    <name>Q39SP8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2504"/>
    <dbReference type="EnsemblBacteria" id="ABB32726">
        <property type="protein sequence ID" value="ABB32726"/>
        <property type="gene ID" value="Gmet_2504"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2504"/>
    <dbReference type="HOGENOM" id="CLU_207127_0_0_7"/>
    <dbReference type="OMA" id="HMCALKA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="55" mass="5636" checksum="1D450AF57C2B5B2B" modified="2005-11-22" version="1">MACDITSHKMHMCALKAEGCSDEIASLSASPTVKCGNCGALANSPDNVCNPVPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SP9</accession>
    <name>Q39SP9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366065.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2503"/>
    <dbReference type="EnsemblBacteria" id="ABB32725">
        <property type="protein sequence ID" value="ABB32725"/>
        <property type="gene ID" value="Gmet_2503"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2503"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_1_1_7"/>
    <dbReference type="OMA" id="FRIPVTF"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="109" mass="12447" checksum="D31762B27794E409" modified="2005-11-22" version="1">MGMVVKRFDVYLVNLDPTVGREIRKARPCLIISPDEMNRYIGTVIVAPMTTKGRDYPTRVQCSFKGKEGQVVLDQIRTVDKSRLFQKLGRIDKETQEEVLSILAEMFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SY9</accession>
    <name>Q39SY9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Superoxide dismutase</fullName>
            <ecNumber evidence="2">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sodA</name>
        <name evidence="7" type="ordered locus">Gmet_2410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512490.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2410"/>
    <dbReference type="EnsemblBacteria" id="ABB32635">
        <property type="protein sequence ID" value="ABB32635"/>
        <property type="gene ID" value="Gmet_2410"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2410"/>
    <dbReference type="eggNOG" id="COG0605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031625_2_2_7"/>
    <dbReference type="OMA" id="DHHGNVG"/>
    <dbReference type="OrthoDB" id="1440645at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="SSF46609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="SSF54719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sod_Fe_C" evidence="6">
        <location>
            <begin position="91"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="192" mass="21624" checksum="47C6F23E7D59514D" modified="2005-11-22" version="1">MAYEAKDYAKLLGMEGFSEALLKNHFTLYQGYVTNTNKVLDILDGMLKAGNTAAPEYAELKRRLGWEFNGMRLHEFYFENLGGKGGIDQAGKLAAKMAADFGSVEAWEKDFRATGAMRGIGWAVLYQDSASGRLMNFWINEHDVAHPAGCAPILIMDVFEHAFMLDYGLKRADYIEAFFRNIDWKAAEARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T07</accession>
    <name>Q39T07_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32617">
        <property type="protein sequence ID" value="ABB32617"/>
        <property type="gene ID" value="Gmet_2392"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2392"/>
    <dbReference type="HOGENOM" id="CLU_213222_0_0_7"/>
    <dbReference type="OMA" id="TIKTAMF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="54" mass="6186" checksum="11F22560A1C636C7" modified="2005-11-22" version="1">METIKTALFETLMESAVPDGDNGYIFTLEGKTYRIRDTLEISKIAQDHGYIIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T18</accession>
    <name>Q39T18_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_2381</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514760.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2381"/>
    <dbReference type="EnsemblBacteria" id="ABB32606">
        <property type="protein sequence ID" value="ABB32606"/>
        <property type="gene ID" value="Gmet_2381"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2381"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034283_0_0_7"/>
    <dbReference type="OMA" id="FALIWPI"/>
    <dbReference type="OrthoDB" id="854536at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="82"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="569" mass="61919" checksum="7B779E87582E27F5" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T48</accession>
    <name>Q39T48_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-2-acetamido-2-deoxy-alpha-D-ribo-hexopyranos-3-ulose 3-aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gnnB</name>
        <name evidence="4" type="ordered locus">Gmet_2351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513269.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2351"/>
    <dbReference type="EnsemblBacteria" id="ABB32576">
        <property type="protein sequence ID" value="ABB32576"/>
        <property type="gene ID" value="Gmet_2351"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2351"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_7_2_7"/>
    <dbReference type="OMA" id="IGCEIYY"/>
    <dbReference type="OrthoDB" id="1006364at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="366" mass="39682" checksum="45500EECD169F4E0" modified="2005-11-22" version="1">MNIPMVDLKVQYHAIKEEIDRGILEALEKTQFILGPNVTAFEEEAAAFLGVKHAIGVASGTDALHLALAAAGITEGDEVITSPFTFIATAEAIRYVGATPVFVDVDPKSFNIDPARIEAAITPRTKAVLPVHLFGQPADMDAIQALCTKHGLLMIEDCAQSFGADVNGRMTGTFGALGAFSFFPSKNLGCYGDGGLVTTSCPELAERVKVLRNHGSKVRYHHSVIGYNSRLDEIQAVILRVKLKHIREYSEGRRRVAHLYSELLAGTGATPPFEDGKGTHVYHQYTLLTDRRDAIMKALTDAGIASAVYYPIPLHKQDVFAADYAGVSLPAAEEVASRCMSLPIFPEMTEEQVRRVVDVVKSALKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T54</accession>
    <name>Q39T54_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose--lipopolysaccharide heptosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513275.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2345"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32570">
        <property type="protein sequence ID" value="ABB32570"/>
        <property type="gene ID" value="Gmet_2345"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2345"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_0_0_7"/>
    <dbReference type="OMA" id="GSAKRWP"/>
    <dbReference type="OrthoDB" id="1068323at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011910">
        <property type="entry name" value="RfaF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02195">
        <property type="entry name" value="heptsyl_trn_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="359" mass="38871" checksum="DD51B24253C9B17B" modified="2005-11-22" version="1">MTDSISALDKSAIRTILVRAVNWLGDAVMTTPALRAIRESFPEARITVLANPLVAELFANHETVDAVHVYDRKGRHAGIRGRIRLARELRAERFDLAILLQNAIDAALIARLARIPRIMGYRTDGRGMLLTHGAPVTIEAKKLHHVDYYLAMLSRFGIETGAKHLSLTVTREEKEGTARLLAAAGIGANDFVIGINPGATYGSAKRWYPERFAAVADELSLRWGARVVVTGGPGEAAIAADIAAAMTVPALVMAGKTSVRELMALIKRCDFFITNDSGPMHIAAAFSVPLVAVFGPTDHTTTSPWSDRAAVVRRDTDCAPCLLRECPTDHRCMTAVTMTDVVEAAERLRTCVAALEHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T83</accession>
    <name>Q39T83_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2316</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513304.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2316"/>
    <dbReference type="EnsemblBacteria" id="ABB32541">
        <property type="protein sequence ID" value="ABB32541"/>
        <property type="gene ID" value="Gmet_2316"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2316"/>
    <dbReference type="eggNOG" id="COG1243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057482_0_0_7"/>
    <dbReference type="OMA" id="PIFIPQY"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF0">
        <property type="entry name" value="PTHR11135:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="1"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="346" mass="36961" checksum="A13B31A3FA7B1B1A" modified="2005-11-22" version="1">MKPLIVPFFISHQGCPHQCVFCDQERISGQRPGLPEPEEMIATIDRHAASGRGRPLEVAFYGGTFTSLPRSDQERLLAPLQPLMATGSVARVRLSTRPDAVDGETARFLASRGVATVELGVQSMDDAVLTAAGRGHGAAHVEQAFASLCGAGIDVGAQLMPGLPGDTADSTLESLERVLALSPAFMRIYPTLVVEGTRLAELWRSGDYTPLALDDAVSLCAAMLRRCISAGVPVIRIGLQPTEELERPGTVLAGPWHPAFRQLAESELFFDLLQRLTAGIPAGSDLVVVCAPRRLSDVAGQHRRNLVRLRERSGVAVTRVTGSSHLSPYDLEVVYAGGTIAGNVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T90</accession>
    <name>Q39T90_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scaffold protein CheW associated with MCPs of class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheW40H-1</name>
        <name evidence="3" type="ordered locus">Gmet_2309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513311.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2309"/>
    <dbReference type="EnsemblBacteria" id="ABB32534">
        <property type="protein sequence ID" value="ABB32534"/>
        <property type="gene ID" value="Gmet_2309"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2309"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060740_0_0_7"/>
    <dbReference type="OMA" id="PARFTTW"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="2">
        <location>
            <begin position="98"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="238" mass="26157" checksum="EE8B6000C15A0164" modified="2005-11-22" version="1">MMDIAEIRKKAQREREGRREEPQAAQSPVTPSAPPLEETDDGHYDESFPQDEIIQASFAPPVVRDPLTVILEGRKSALVDEVLPVEDDADLPVQASSSLEILCFRVADEIYGIDIMELKEIIKPRETTEVPHAPPFIAGVLSLRGIIIPVFALRERLGLCREEGGGKERIIVVKKGDGLCGILVDEVTQVVRIAADTVEQPPAVLDGIDREFVSGIGRHDGKIVIMLAMEKVLDVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TA5</accession>
    <name>Q39TA5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aminopeptidase, M42 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase M42 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514504.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2294"/>
    <dbReference type="EnsemblBacteria" id="ABB32519">
        <property type="protein sequence ID" value="ABB32519"/>
        <property type="gene ID" value="Gmet_2294"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2294"/>
    <dbReference type="eggNOG" id="COG1363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047249_1_0_7"/>
    <dbReference type="OMA" id="FGWPAIH"/>
    <dbReference type="OrthoDB" id="900854at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008007">
        <property type="entry name" value="Peptidase_M42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023367">
        <property type="entry name" value="Peptidase_M42_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05343">
        <property type="entry name" value="Peptidase_M42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001123">
        <property type="entry name" value="PepA_GA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001123-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="356" mass="38423" checksum="651B28120AD44E4B" modified="2005-11-22" version="1">MRQESLDFFKQLVEAPSPSGYEQPAQRVFRDYIAPFAEVTTDVMGNVFGLIRGEGEDLPRVMIVGHSDEIGFQVKYIDDNGFIFFAPIGGVDAHLTPGKRVRIHTAKGEVAGVIGKKPIHLMDEEDRKKVVRLDAQYIDIGAADKNDAQEAVRVGDPVTFAVGFESLLGDRVASRAFDDKAGSFVVAEVLRTVAESGVKLPVDLYGVSSVQEEIGLRGGTTSSYSVNPHVGICVEVDFATDQPDVEKKHNGEVKLGKGPILPRGANINHPLFDLLSATADREGIAVQYTGIARATGTDANVMQISRGGVATALVKLPLRYMHTPVEVISLSDLENAVRLIVAALPGMGKKEAFILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TB9</accession>
    <name>Q39TB9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2280"/>
    <dbReference type="EnsemblBacteria" id="ABB32505">
        <property type="protein sequence ID" value="ABB32505"/>
        <property type="gene ID" value="Gmet_2280"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2280"/>
    <dbReference type="HOGENOM" id="CLU_1756194_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223106" evidence="1">
        <location>
            <begin position="24"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="148" mass="16878" checksum="724508AA277C7208" modified="2005-11-22" version="1">MMPMRAKSILLFMVIALYPTFVAALDSEEKYTGFHIDVYDEALTNKVIANAAKCEVIDQLLNGERKSCYLSNAIHKIISEPDNKLVRYMPLRNNYNRLFIEYEVAYHALRNAQFGALKTMKTLNAISVSGLLEMYSKSNCPELNKSQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TI2</accession>
    <name>Q39TI2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">4-hydroxybutyryl-CoA dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365971.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2215"/>
    <dbReference type="EnsemblBacteria" id="ABB32442">
        <property type="protein sequence ID" value="ABB32442"/>
        <property type="gene ID" value="Gmet_2215"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2215"/>
    <dbReference type="eggNOG" id="COG2368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023920_1_0_7"/>
    <dbReference type="OMA" id="GWDALNT"/>
    <dbReference type="OrthoDB" id="418642at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004925">
        <property type="entry name" value="HpaB/PvcC/4-BUDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024719">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024674">
        <property type="entry name" value="HpaB/PvcC/4-BUDH_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36117">
        <property type="entry name" value="PTHR36117"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03241">
        <property type="entry name" value="HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11794">
        <property type="entry name" value="HpaB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000331">
        <property type="entry name" value="HpaA_HpaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpaB_N" evidence="3">
        <location>
            <begin position="6"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="HpaB" evidence="2">
        <location>
            <begin position="284"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000331-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="483" mass="53358" checksum="816B01311600CE91" modified="2005-11-22" version="1">MALRDGNSYRESLRALNIKVYAFGEKIDSIVDHPLFQPHINAAALTFDLAHDPTTEALVTATSHLTGSKISRFTHIHQSTDDLIKKVKMLRLIAGKTGSCYQRCVGWDALNANYTVTYEMDQELGTDYHQRFRRYLEYIQDNDLMVAGAMTDPKGDRGLPPAKQKDPDMFVHVVAKNDKGIVIRGAKVHQTGIVNSHEMLIMPTMAMGEEDGDYAVACALPTDSPGVIHIFGRQTNDTRRLEKGDLDQGNAEYGTVGGEALTILEDVFVPWERVFMCGEYKYAGLLVERFASYHRQNYGGCKAGVSDVIIGATTAMAEYNGAAKASHVRDKIVEMVHLTETLYCGSIACSCEGAPTPSGAYFVNPLLANTVKQNVTRFIYEIARLSHDISGGCMATMPSEKDLHHDEIGKYVEKYFRGVDEAPTEERMRMARLVENMTGGTALVESMHGAGSPQAQRVMILRQANLGHKVKLAKKLAGIKEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TL1</accession>
    <name>Q39TL1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2185"/>
    <dbReference type="EnsemblBacteria" id="ABB32413">
        <property type="protein sequence ID" value="ABB32413"/>
        <property type="gene ID" value="Gmet_2185"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2185"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_417841_0_0_7"/>
    <dbReference type="OMA" id="NLYWSTT"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043724">
        <property type="entry name" value="DUF5666"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18914">
        <property type="entry name" value="DUF5666"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223378" evidence="1">
        <location>
            <begin position="24"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="317"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="410"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="503"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="656" mass="65749" checksum="C76D48DD30B06A54" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TT1</accession>
    <name>Q39TT1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic catabolism-like sigma-54-dependent transcriptional regulator, XylR and V4R domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2114</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513091.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2114"/>
    <dbReference type="EnsemblBacteria" id="ABB32343">
        <property type="protein sequence ID" value="ABB32343"/>
        <property type="gene ID" value="Gmet_2114"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2114"/>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_2_7"/>
    <dbReference type="OMA" id="IYKETEC"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010523">
        <property type="entry name" value="XylR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06505">
        <property type="entry name" value="XylR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="238"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="573" mass="63305" checksum="B50B10C62DF8D0A8" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TY9</accession>
    <name>Q39TY9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amidohydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514047.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2056"/>
    <dbReference type="EnsemblBacteria" id="ABB32285">
        <property type="protein sequence ID" value="ABB32285"/>
        <property type="gene ID" value="Gmet_2056"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2056"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_975772_0_0_7"/>
    <dbReference type="OMA" id="VRVNFPH"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="6"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="285" mass="32510" checksum="0D1ED3C077EE5EA8" modified="2005-11-22" version="1">MTSEIIDVHMHCFVGRQQETALARDIALLRREGLRRMVVAGLVNTHPDPETTWNLIPDYVENHGDPHFNEADDLLALAESVDHALLPFVDTRYLRGDVATALDGYMGQGFKGVKGIYLPDNENDLGVGNVPDTLGISLEQYRRREWDLFAYAENHDLPLLYHMDARRYGDVMKDLLDDFPRVRVNFPHLGIGRKAFSAFLDRYPNIFTDIAGLLPYMRSNPASYRDFIMHYPDRICFGTDTFLYQAGSALDYISMVRELRLPEEIEAQVFNGNPTRFLGCVLYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U10</accession>
    <name>Q39U10_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2035</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512916.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2035"/>
    <dbReference type="EnsemblBacteria" id="ABB32264">
        <property type="protein sequence ID" value="ABB32264"/>
        <property type="gene ID" value="Gmet_2035"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2035"/>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_805991_0_0_7"/>
    <dbReference type="OMA" id="ITFRTRL"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="126"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="344" mass="37471" checksum="8B8454EBC99304E1" modified="2005-11-22" version="1">MVFYSFDVAPNLTLSSCDEAAEQIIGTPAALLAGKPYYEVFPRVLYQDRDAVAEVVQSGIPLLLRDYSVICILGRTLADIRLEPVLNQESAVGAVRVSVCASETCSRALELKGASTLIDIGKVSATLAHGVRNPLNAIKGAVVYLKHRYGSDETFVEFADIIDEEIAKLDGFITKFLSTSLLEMEKSRSDLHVLLEKVLKITSLQAQERDIRFVCDYGDVPFLEFDAFHLESAILNIVNNAIEAMGSGGTITFRTRLDTMADRRQVTLDISDSGPGIPEGAFHNLLLPPRGNTRDKGRGFGLFISREIIQYHGGSLEIINSKGNGATVRLSLPVESSHGETHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U46</accession>
    <name>Q39U46_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512951.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1999"/>
    <dbReference type="EnsemblBacteria" id="ABB32228">
        <property type="protein sequence ID" value="ABB32228"/>
        <property type="gene ID" value="Gmet_1999"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1999"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_310319_0_0_7"/>
    <dbReference type="OMA" id="HANANSF"/>
    <dbReference type="OrthoDB" id="442785at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="948" mass="104893" checksum="BF934885022073EC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UE3</accession>
    <name>Q39UE3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Carbon monoxide dehydrogenase</fullName>
            <ecNumber evidence="6">1.2.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cooS</name>
        <name evidence="9" type="ordered locus">Gmet_1902</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>CO + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = CO2 + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:21040"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.2.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="1.2.7.4" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511942.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1902"/>
    <dbReference type="EnsemblBacteria" id="ABB32131">
        <property type="protein sequence ID" value="ABB32131"/>
        <property type="gene ID" value="Gmet_1902"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1902"/>
    <dbReference type="eggNOG" id="COG1151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030631_0_0_7"/>
    <dbReference type="OMA" id="NGCASFP"/>
    <dbReference type="OrthoDB" id="136177at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018492">
        <property type="term" value="F:carbon-monoxide dehydrogenase (acceptor) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043885">
        <property type="term" value="F:carbon-monoxide dehydrogenase (ferredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01915">
        <property type="entry name" value="CODH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016101">
        <property type="entry name" value="CO_DH_a-bundle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010047">
        <property type="entry name" value="CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005023">
        <property type="entry name" value="CODH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01702">
        <property type="entry name" value="CO_DH_cata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0533">Nickel</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="485"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>[Ni-4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:47739"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR005023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005023-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="669" mass="71227" checksum="310B2E8E89CC88E6" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UU1</accession>
    <name>Q39UU1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH-dependent glutamate synthase, GXGXG domain subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1752</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513352.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1752"/>
    <dbReference type="EnsemblBacteria" id="ABB31983">
        <property type="protein sequence ID" value="ABB31983"/>
        <property type="gene ID" value="Gmet_1752"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1752"/>
    <dbReference type="eggNOG" id="COG0070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078510_1_0_7"/>
    <dbReference type="OMA" id="PYIEEFC"/>
    <dbReference type="OrthoDB" id="1467316at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00981">
        <property type="entry name" value="arch_gltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035710">
        <property type="entry name" value="Archaeal_gltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002489">
        <property type="entry name" value="Glu_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036485">
        <property type="entry name" value="Glu_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012061">
        <property type="entry name" value="Glu_synth_lsu_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01493">
        <property type="entry name" value="GXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006519">
        <property type="entry name" value="GOGAT_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69336">
        <property type="entry name" value="SSF69336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GXGXG" evidence="1">
        <location>
            <begin position="17"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="249" mass="27167" checksum="7B4D9BF1ED128F88" modified="2005-11-22" version="1">MTKIDAQGLYYRDLNLKIREAVAAGAAEIVLDNVNGQYFIGDGINRPVTIAINGVPGNDLAAFMNGATIVVNDNAQDNIGNTMNAGKVIVHGHAGDVLGYGMRGGRVHIRKDVGYRVGIHMKSYESNKPVLIAGGKAGDFFGEYMAGGVLILLDLFSDEPEKPKHGFRFGTGMHGGTIFVRGGVDETKLSREVGVFELTDEDRLELEGYLKEYCNDFGIDYADVAKEEFVKVLPLSRRPYGNLYCPMPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V05</accession>
    <name>Q39V05_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1688</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514166.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1688"/>
    <dbReference type="EnsemblBacteria" id="ABB31919">
        <property type="protein sequence ID" value="ABB31919"/>
        <property type="gene ID" value="Gmet_1688"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1688"/>
    <dbReference type="eggNOG" id="COG1560">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049421_2_0_7"/>
    <dbReference type="OMA" id="YPLQWFN"/>
    <dbReference type="OrthoDB" id="1106624at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07984">
        <property type="entry name" value="LPLAT_LABLAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004960">
        <property type="entry name" value="LipA_acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30606">
        <property type="entry name" value="PTHR30606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03279">
        <property type="entry name" value="Lip_A_acyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="297" mass="33785" checksum="776856AEFCA2D9F5" modified="2005-11-22" version="1">MTYYNSINLFLINLFTRLVPRWLFPPFAFVTAGIVYFLAGTQRRGTRENLRVVTGRRHVEGLLISTFYKYARNWADVMLMMRLTGERLFSLIGRRSMSTPLDEALAAGTGAILVSPHFGNWELGGLGLADLGYKINVLTFREPDEKVNELRERVRGERGIGFIYVDRHDTSPLAIIEAVNALRRNEVVALLGDRDGSSHTMSVEFFGRPANIPLGAAYLSLASGAPVIPVFVPLEGGRYATIMEEPIHFRSGHRDHGIVIREGVERLIRLFEKYIRVYPDQWYNFFPYWDQSSHTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V36</accession>
    <name>Q39V36_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">6-carboxy-5,6,7,8-tetrahydropterin synthase</fullName>
            <ecNumber evidence="8">4.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">queD</name>
        <name evidence="11" type="ordered locus">Gmet_1657</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>7,8-dihydroneopterin 3'-triphosphate + H2O = 6-carboxy-5,6,7,8-tetrahydropterin + acetaldehyde + 2 H(+) + triphosphate</text>
            <dbReference type="Rhea" id="RHEA:27966"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="EC" id="4.1.2.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8 10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the PTPS family. QueD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.-.-.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511406.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1657"/>
    <dbReference type="EnsemblBacteria" id="ABB31888">
        <property type="protein sequence ID" value="ABB31888"/>
        <property type="gene ID" value="Gmet_1657"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1657"/>
    <dbReference type="eggNOG" id="COG0720">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111016_6_3_7"/>
    <dbReference type="OMA" id="MHISAAH"/>
    <dbReference type="OrthoDB" id="1770189at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070497">
        <property type="term" value="F:6-carboxy-5,6,7,8-tetrahydropterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007115">
        <property type="entry name" value="6-PTP_synth/QueD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038418">
        <property type="entry name" value="6-PTP_synth/QueD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12589">
        <property type="entry name" value="PTHR12589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01242">
        <property type="entry name" value="PTPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006113">
        <property type="entry name" value="PTP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03367">
        <property type="entry name" value="queuosine_QueD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="9">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006113-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="122" mass="13978" checksum="8928CDEA2CD6182F" modified="2005-11-22" version="1">MYKLAIHTSFAAAHCLINYQGDCENLHGHNWKVEVTVTARELDKAGLGIDFKILKQETNAILRTLDHKYLNELTPFREISPSSENISRFLYEELSKRLNDGNVKVESITVWESDNAAATYYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V69</accession>
    <name>Q39V69_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Riboflavin biosynthesis protein RibD</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Diaminohydroxyphosphoribosylaminopyrimidine deaminase</fullName>
                <shortName evidence="10">DRAP deaminase</shortName>
                <ecNumber evidence="10">3.5.4.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Riboflavin-specific deaminase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">5-amino-6-(5-phosphoribosylamino)uracil reductase</fullName>
                <ecNumber evidence="10">1.1.1.193</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">HTP reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="15" type="primary">ribD</name>
        <name evidence="15" type="ordered locus">Gmet_1624</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(+) + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21868"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5-amino-6-(5-phospho-D-ribitylamino)uracil + NADP(+) = 5-amino-6-(5-phospho-D-ribosylamino)uracil + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17845"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58421"/>
            <dbReference type="ChEBI" id="CHEBI:58453"/>
            <dbReference type="EC" id="1.1.1.193"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10 13">Binds 1 zinc ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Cofactor biosynthesis; riboflavin biosynthesis; 5-amino-6-(D-ribitylamino)uracil from GTP: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">In the C-terminal section; belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.26" evidence="10"/>
    <dbReference type="EC" id="1.1.1.193" evidence="10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511440.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1624"/>
    <dbReference type="EnsemblBacteria" id="ABB31855">
        <property type="protein sequence ID" value="ABB31855"/>
        <property type="gene ID" value="Gmet_1624"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1624"/>
    <dbReference type="eggNOG" id="COG0117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036590_1_2_7"/>
    <dbReference type="OMA" id="PYIILKW"/>
    <dbReference type="OrthoDB" id="1775351at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00401"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008835">
        <property type="term" value="F:diaminohydroxyphosphoribosylaminopyrimidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004794">
        <property type="entry name" value="Eubact_RibD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011549">
        <property type="entry name" value="RibD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006769">
        <property type="entry name" value="RibD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00326">
        <property type="entry name" value="eubact_ribD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00227">
        <property type="entry name" value="ribD_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 12" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="8 10 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="3"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006769-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB31855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="370" mass="39527" checksum="6C1541FDE0FC580C" modified="2005-11-22" version="1">MDVSPEKIMKRALALARRGKGKTSPNPAVGCVIVRDGAIVGEGWHRKAGTPHAEVHALRQAGELARGADVYVTLEPCSHFGKTPPCADALVEAGVGRVFVGMVDPNPKVSGRGIERLRVAGIEVVTGIREAECRRLNEPFVKHVTTGLPFVILKSAMTMDGKTATASGDSRWITNEKSRRYVHKLRSMVDAIMVGVGTVLADDPQLTARIPRGKDPVRVVVDSSLRIPSGARMLHQESPATTVVATVSEDRNRIVKLESAGAEVLRCHAVMGRIDLRDLLARLGARGVQSILLEGGSELAGEALRAGLIDKCVLFYAPKFLGGAAGLGLFGGPSAERMDGCCRLKDVSVRRFGDDVMIEAYPEDLCLPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V73</accession>
    <name>Q39V73_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase, HDc domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511444.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1620"/>
    <dbReference type="EnsemblBacteria" id="ABB31851">
        <property type="protein sequence ID" value="ABB31851"/>
        <property type="gene ID" value="Gmet_1620"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1620"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073842_0_1_7"/>
    <dbReference type="OMA" id="CYADKFF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="21"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="181" mass="20330" checksum="F276F51E9C65E543" modified="2005-11-22" version="1">MNVEHILTRHFGEETRACAIVLEHSRMVADKALRIARTLNDPDLDLRFIEEAALLHDIGVCGTDSPGIGCSGDSPYILHGIIGREILEAEGLPRHAMVCERHIGVGLTVDDIVRQGLPLPLREMVPVTREERIICYADLFFSKKGNSLNHEKSPPEIRKGLIRHGEHRVAIFEQWLLEFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V89</accession>
    <name>Q39V89_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">3-oxoacyl-[acyl-carrier-protein] synthase 2</fullName>
            <ecNumber evidence="3 10">2.3.1.179</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fabF-2</name>
        <name evidence="14" type="ordered locus">Gmet_1603</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(9Z)-hexadecenoyl-[ACP] + H(+) + malonyl-[ACP] = 3-oxo-(11Z)-octadecenoyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:55040"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10800"/>
            <dbReference type="Rhea" id="RHEA-COMP:14074"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:83989"/>
            <dbReference type="ChEBI" id="CHEBI:138538"/>
            <dbReference type="EC" id="2.3.1.179"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a fatty acyl-[ACP] + H(+) + malonyl-[ACP] = a 3-oxoacyl-[ACP] + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10 12">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.179" evidence="3 10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511462.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1603"/>
    <dbReference type="EnsemblBacteria" id="ABB31835">
        <property type="protein sequence ID" value="ABB31835"/>
        <property type="gene ID" value="Gmet_1603"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1603"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_7"/>
    <dbReference type="OMA" id="QIGHCLG"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000447">
        <property type="entry name" value="KAS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="13">
        <location>
            <begin position="4"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000447-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB31835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="410" mass="43422" checksum="730683379A0D498C" modified="2005-11-22" version="1">MRRVVVTGVGAISPLGTGNGKNWDALVAGRSGIDLITRFDASELPVKIAGEVKDFTPEDFIEKKEVKKMDLFIQYALAAAQFAMEDSGLQITDENAERVGVIVGAGLGGLPTIEKYHAAMLEGGYKKISPFFIPMLIINLAPGHISIKYGAKGPNLSSVSACATGTHSIGDAYHMIKRGDADAMIAGGTESTVTPLGIGGFAVMKALSTRNDDPKGASRPFEKSRDGFVLAEGAGIVILEEYESAKKRGAKIYAEVVGYGLSGDAYHLTAPAPEGEGAARCIKMALNNAGINADQVDYINAHGTSTHFNDYYETLAIKKVFGDHAKKIMVSSTKSMTGHLLGAAGGVEAVFSLMAMDKGVVPPTINYQEQDSECDLDYVPNTARDAKITYAMSNNFGFGGTNASLLFKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V91</accession>
    <name>Q39V91_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabG-2</name>
        <name evidence="4" type="ordered locus">Gmet_1601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511464.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1601"/>
    <dbReference type="EnsemblBacteria" id="ABB31833">
        <property type="protein sequence ID" value="ABB31833"/>
        <property type="gene ID" value="Gmet_1601"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1601"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="KHMVDAG"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="246" mass="25591" checksum="AA050262A42226C9" modified="2005-11-22" version="1">MSLEGKVAIVTGASRGIGRAIALKLAREGASVVVTATTLESARKTAAEIEALGHKALSLAVDVADSSAVEAMFVSAVGAFGKVDILVNNAGITKDGLLLRMKDADWDAVIDVNLKGAFNCIREAAKLMVKARSGRIVNISSVVGEMGNAGQINYCASKAGMIGLTKSAARELAKRGITVNAVTPGFIETNMTSVLSDKVREGLLQQIPLERLGTSDDVANAVFFLVSSMGDYITGHVLSVNGGMYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VK1</accession>
    <name>Q39VK1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 2-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UDP-N-acetylglucosamine 2-epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31723.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365831.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1489"/>
    <dbReference type="EnsemblBacteria" id="ABB31723">
        <property type="protein sequence ID" value="ABB31723"/>
        <property type="gene ID" value="Gmet_1489"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1489"/>
    <dbReference type="eggNOG" id="COG0381">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041674_1_0_7"/>
    <dbReference type="OMA" id="RYNTERP"/>
    <dbReference type="OrthoDB" id="1117971at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008761">
        <property type="term" value="F:UDP-N-acetylglucosamine 2-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003331">
        <property type="entry name" value="UDP_GlcNAc_Epimerase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029767">
        <property type="entry name" value="WecB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43174">
        <property type="entry name" value="PTHR43174"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02350">
        <property type="entry name" value="Epimerase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00236">
        <property type="entry name" value="wecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase_2" evidence="2">
        <location>
            <begin position="22"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31723.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="382" mass="42363" checksum="10CB1FF75FBC9ECC" modified="2012-10-31" version="2">MFVFGTRPEAIKMAPLVKELQKQAGQFKTIVCVSAQHRQMLDQVLQLFDIRPEYDLDIMKPGQDLFDITSNVLLGLKPVLTKEQPDILLVHGDTTTTMSAALAAYYCRIPVGHVEAGLRTYNKFSPFPEEMNRRTAGALTDLHFAPTETARRNLLSEGVADTSIFVTGNTVIDALFSVIGEINANRELKESLSTQFQFLDPHKRLILVTGHRRENFGAGFESICRAIARIAERYPDVEILYPVHLNPNVREPVRRLLGNGKLSNVHLIEPVDYLPFVYLMAQSYLIITDSGGVQEEAPSLGKPVLVMRDTTERPEAIGAGTVKLVGTREESIYREAARLLDAADAYQVMSQALNPYGDGRAAERIAKCLADFPNTCMGGQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VR5</accession>
    <name>Q39VR5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylmuramoyl-L-alanine amidase</fullName>
            <ecNumber evidence="2">3.5.1.28</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1425</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in certain cell-wall glycopeptides.</text>
            <dbReference type="EC" id="3.5.1.28"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.5.1.28" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511643.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1425"/>
    <dbReference type="EnsemblBacteria" id="ABB31659">
        <property type="protein sequence ID" value="ABB31659"/>
        <property type="gene ID" value="Gmet_1425"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1425"/>
    <dbReference type="eggNOG" id="COG0860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014322_2_0_7"/>
    <dbReference type="OMA" id="KRYFAAN"/>
    <dbReference type="OrthoDB" id="1184688at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008745">
        <property type="term" value="F:N-acetylmuramoyl-L-alanine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009253">
        <property type="term" value="P:peptidoglycan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02696">
        <property type="entry name" value="MurNAc-LAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002508">
        <property type="entry name" value="MurNAc-LAA_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01520">
        <property type="entry name" value="Amidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00646">
        <property type="entry name" value="Ami_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="MurNAc-LAA" evidence="5">
        <location>
            <begin position="262"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="423" mass="46327" checksum="7A9F837456FFA451" modified="2005-11-22" version="1">MRIQRWLRIVPLLFALAGVLFLFSSAEAKEVRRVKGSSVKATAVVKEMRHWSNPDYTRIAITVDREAHFETHQIKQHPGDALPSRIYLDITGARVGPGVHDLQIADQQLKSARVGQYKPDVVRVVLDVDRIKEFKVFSLSDPFRIIVDVKGERPLEFAKLTEQVQPAPAPTSAAETKAADTSDEKPSPKPVAKFKPGKIRRIVVDPGHGGHDPGAIGAGGTQEKDVVLALGLQLAAKIREELGIDVVMTRSTDVFIPLEERTAIANKVNADLFVSVHANASLNRGTSGIETYYLNLAKTEKAAQLAARENGTSLDKVSLLQAILFDLMANYKLNDSAHLADEVQKALYKKINGHYPGTRNLGVKQGPFYVLVGATMPSILVETAFISNETEEARLRDKAFLDRAADGIVDGIKGYIRTIGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VU0</accession>
    <name>Q39VU0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geopilin domain 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilA-C</name>
        <name evidence="2" type="ordered locus">Gmet_1400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1400"/>
    <dbReference type="EnsemblBacteria" id="ABB31634">
        <property type="protein sequence ID" value="ABB31634"/>
        <property type="gene ID" value="Gmet_1400"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1400"/>
    <dbReference type="HOGENOM" id="CLU_2129857_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223186" evidence="1">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="113" mass="11596" checksum="AF17C49B33A789CB" modified="2005-11-22" version="1">MKKKIFLTGLCFLSIGSVAFAASKDVTGSGEIGGSNSTPKLAIQTSNQVTLTYDGGTGHTYGIATLHAKGTRKYASTSNDTKIYYNDNTATAAPSAPVGTATIGGSTNWKNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VW2</accession>
    <name>Q39VW2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1378</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513130.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1378"/>
    <dbReference type="DNASU" id="3740642"/>
    <dbReference type="EnsemblBacteria" id="ABB31612">
        <property type="protein sequence ID" value="ABB31612"/>
        <property type="gene ID" value="Gmet_1378"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1378"/>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_7"/>
    <dbReference type="OMA" id="FHEMLEL"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006276">
        <property type="term" value="P:plasmid maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008813">
        <property type="entry name" value="Plasmid_replication_RepL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05732">
        <property type="entry name" value="RepL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="219" mass="24472" checksum="9A160A453D10181E" modified="2005-11-22" version="1">MNVTALQQMTVLFVDDEEIAREQMKMVLSSFCKNTICVGSADQALAALQEHHPDIVLTDIRMPGLSGIELLNAVKQKDASVAVVIVSAHSESEYLLDAFRYKADGYLLKPFNFHEMLELLSDIATQKEAASSERKQGPDNRDFLLKILDTLGGRRAEIMEYVINHLDADNLFHGTYDEVAEALSASKPTVVATFQIMLEKNVLTRLKYGTYRMNVDATI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W28</accession>
    <name>Q39W28_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase of ISGme5, ISL3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0323</name>
        <name evidence="5" type="ordered locus">Gmet_1310</name>
        <name evidence="6" type="ordered locus">Gmet_2515</name>
        <name evidence="7" type="ordered locus">Gmet_3527</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="5">GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="5">GS-15</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365652.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0323"/>
    <dbReference type="DNASU" id="3739481"/>
    <dbReference type="EnsemblBacteria" id="ABB30566">
        <property type="protein sequence ID" value="ABB30566"/>
        <property type="gene ID" value="Gmet_0323"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31546">
        <property type="protein sequence ID" value="ABB31546"/>
        <property type="gene ID" value="Gmet_1310"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32736">
        <property type="protein sequence ID" value="ABB32736"/>
        <property type="gene ID" value="Gmet_2515"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33732">
        <property type="protein sequence ID" value="ABB33732"/>
        <property type="gene ID" value="Gmet_3527"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0323"/>
    <dbReference type="KEGG" id="gme:Gmet_1310"/>
    <dbReference type="KEGG" id="gme:Gmet_2515"/>
    <dbReference type="KEGG" id="gme:Gmet_3527"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041900_0_2_7"/>
    <dbReference type="OMA" id="RNYTKRY"/>
    <dbReference type="OrthoDB" id="1128314at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032877">
        <property type="entry name" value="Transposase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13542">
        <property type="entry name" value="HTH_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="3">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_ISL3" evidence="2">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="158"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="407" mass="46772" checksum="DFE501E2BD23C5FF" modified="2005-11-22" version="1">MSYSDVIAIAGGWEGYRVAGARTIVTSDAKRIEVELIALSQDEMVCGSCGGRCTSVHETTKRVIRDLPILDAQTYLIVHRRRLLCPQCGPTLERLSWLAKYARVTRRLAESVARLCGVVSVKHVAQYLGLSWDQVKEIDKRSLTERVGTVDLSNIEVLGMDEFALHKGHRYATVIIEPYRKEVLWIGKGRSRESIRPFFTQLGPHGCKRLKAVVMDMNASYEEEIKQHSPQADIVYDLFHVVAKYGREVIDRVRVDEANRLKEDKKARKVVKTSRWLLLRNSENVKGDDMLRLQELLEANRSLLTVYLLKDDLKQLWKFTCIEEAGLFWEQWHQRAMESGIPPLILFARRLKGYLQGILNHCLWPLHTGILEGINNKIKVIKRMAYGFRDHEYFFLKIRAAFPGIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W90</accession>
    <name>Q39W90_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipopolysaccharide ABC transporter, membrane protein LptG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lptG</name>
        <name evidence="7" type="ordered locus">Gmet_1248</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365790.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1248"/>
    <dbReference type="EnsemblBacteria" id="ABB31484">
        <property type="protein sequence ID" value="ABB31484"/>
        <property type="gene ID" value="Gmet_1248"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1248"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_3_2_7"/>
    <dbReference type="OMA" id="WFTSKLA"/>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030923">
        <property type="entry name" value="LptG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04408">
        <property type="entry name" value="LptG_lptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="359" mass="40170" checksum="376871FF303230D1" modified="2005-11-22" version="1">MSILTRYIASAYLRVFWLCLASFIAIYLVIDFLEKIGRFLRFDPQWIHVAQFFLYKIPEIATQVIPLAVLMATLLTLGMLSRNSEIIAMRSCGVSLRKISAPILAIACAASLFVIVSNELILPKTYSQMRFIEEVLIRKKSSNTFLRQNNIWHKDNKAILMARAFDPDHQTLRGVTLWSFSEGMTPSRRIDAEQGSWDGGQWTLWKVTVRDFQGGGVANTTQIASMPVNLNLQIEDLKVVDKYADNMGFLKLREYIQKLKKGGYETTRYEAQMHSKISLPFASLIMAFLGIPFALRGSRSSGVALGIGASIGFGFAYFIINAILISFGQTGVLPSLVSAWAANVIFALSGIWLAMTLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W96</accession>
    <name>Q39W96_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carbonic anhydrase</fullName>
            <ecNumber evidence="3">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + hydrogencarbonate = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512127.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1242"/>
    <dbReference type="EnsemblBacteria" id="ABB31478">
        <property type="protein sequence ID" value="ABB31478"/>
        <property type="gene ID" value="Gmet_1242"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1242"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053879_4_2_7"/>
    <dbReference type="OMA" id="GHEGCGA"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015892">
        <property type="entry name" value="Carbonic_anhydrase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11002">
        <property type="entry name" value="PTHR11002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00704">
        <property type="entry name" value="PROK_CO2_ANHYDRASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223450" description="Carbonic anhydrase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="233" mass="24442" checksum="36E2722294DE8887" modified="2005-11-22" version="1">MNETGRRIARLIIGVAVAASAAVAFASEGGVGVSADEALQRLMDGNKHYVEGQMGACRESDTAKREGLAKGQKPYAIILSCSDSRVPPEIIFDKSMGELFVVRVAGNIPDPVVLGSIEYAAEHIGSPLIMVLGHERCGAVTATVDSKGKAEGNIGALVKTIAPAVQKVKKAMKGKPKAELVEAACDANVKLVAANITKKSPVVAKLVKEGKMKIVTAKYDLDDGKVTLFEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WA6</accession>
    <name>Q39WA6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512137.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1232"/>
    <dbReference type="EnsemblBacteria" id="ABB31468">
        <property type="protein sequence ID" value="ABB31468"/>
        <property type="gene ID" value="Gmet_1232"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1232"/>
    <dbReference type="eggNOG" id="COG0645">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026771_1_1_7"/>
    <dbReference type="OMA" id="FRFVDVM"/>
    <dbReference type="OrthoDB" id="402265at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="1">
        <location>
            <begin position="106"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="525" mass="60132" checksum="A13A10AFA36F121B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WG2</accession>
    <name>Q39WG2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromosome partition protein Smc</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">smc</name>
        <name evidence="5" type="ordered locus">Gmet_1174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for chromosome condensation and partitioning.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="3">Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513440.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1174"/>
    <dbReference type="EnsemblBacteria" id="ABB31412">
        <property type="protein sequence ID" value="ABB31412"/>
        <property type="gene ID" value="Gmet_1174"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1174"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001042_2_2_7"/>
    <dbReference type="OMA" id="HNKIAME"/>
    <dbReference type="OrthoDB" id="1149850at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01894">
        <property type="entry name" value="Smc_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011890">
        <property type="entry name" value="SMC_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="SSF75553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02168">
        <property type="entry name" value="SMC_prok_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="4">
        <location>
            <begin position="524"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="300"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="668"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1176" mass="131829" checksum="1A9E915334B44825" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WH1</accession>
    <name>Q39WH1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cell division protein DivIVA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1165</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513430.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1165"/>
    <dbReference type="EnsemblBacteria" id="ABB31403">
        <property type="protein sequence ID" value="ABB31403"/>
        <property type="gene ID" value="Gmet_1165"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1165"/>
    <dbReference type="eggNOG" id="COG3599">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076854_2_0_7"/>
    <dbReference type="OMA" id="QSIFVAQ"/>
    <dbReference type="OrthoDB" id="875822at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019933">
        <property type="entry name" value="DivIVA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007793">
        <property type="entry name" value="DivIVA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35794">
        <property type="entry name" value="PTHR35794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05103">
        <property type="entry name" value="DivIVA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03544">
        <property type="entry name" value="DivI1A_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="30"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="149" mass="17178" checksum="6AE5020A4F4640A5" modified="2005-11-22" version="1">MRITPLDIQQQQFKGKMLGGLDPHEVDAFLQTVAEEMESLVRENAELKEQCKRATVEMEQMAQQEKNLRETMLAAQKITEEMKANAQKEAALLVSEAEVKGEKIVADAERRLAQLNDQVQEIRRQRLQFESSFKSLLDTHYKMLALDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WS1</accession>
    <name>Q39WS1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fdnT</name>
        <name evidence="7" type="synonym">tatA</name>
        <name evidence="8" type="ordered locus">Gmet_1063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513239.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1063"/>
    <dbReference type="EnsemblBacteria" id="ABB31303">
        <property type="protein sequence ID" value="ABB31303"/>
        <property type="gene ID" value="Gmet_1063"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1063"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_6_1_7"/>
    <dbReference type="OMA" id="MPEMIIV"/>
    <dbReference type="OrthoDB" id="1907955at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="60" mass="6402" checksum="94FE8ED557EB14C5" modified="2005-11-22" version="1">MFGFGMPEMIIVLVIALVVFGPAKLPQLGQSLGAGIRNFKKATLEEPEQIATKDKEEGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WX4</accession>
    <name>Q39WX4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31250.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1008"/>
    <dbReference type="EnsemblBacteria" id="ABB31250">
        <property type="protein sequence ID" value="ABB31250"/>
        <property type="gene ID" value="Gmet_1008"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1008"/>
    <dbReference type="eggNOG" id="COG2413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086367_1_0_7"/>
    <dbReference type="OMA" id="FCDDPKS"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31250.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="208" mass="23518" checksum="CAB99CDD38A09DD3" modified="2012-10-31" version="2">MRKEDRIRRSIAQEAARLMYEEGVREYRDAKRKAARRFGPEKALSLGSHLPSNAEIHGELQRLIGLHEEDVLPERLLRLRCAALRLMEMLAPFEPRLVGSVLTGAVTAHSDIDLHLFAASNEEVEEFLRGKGIPYELEIVTIRHGGEFFDYPHIYLDDDGVVVECTVYPLADIRRIPKSSITGKPMERAGAKKLRKLVAEGEEFDGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WX9</accession>
    <name>Q39WX9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1003</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31245.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31245">
        <property type="protein sequence ID" value="ABB31245"/>
        <property type="gene ID" value="Gmet_1003"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1003"/>
    <dbReference type="eggNOG" id="ENOG502ZC41">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052961_0_0_7"/>
    <dbReference type="OMA" id="GTRHRSM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31245.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="375" mass="42540" checksum="7C03309063A8BB69" modified="2012-10-31" version="2">MASKHKTPSHLAHIVKNELKKRKLLAPPLVVLTELFQTLYFASLKTEESQPINCYIVYINPENPDPKPPERIVKDRWSFIPLGQRVAFSVSSLVKIAKASDPRTSSFAVYHDHNNKLFIWGLLDQGNRYFDYLNFDAESGPERPGLFQASILGIGHLAAYKGYDRIAELNVESIITEAHDVLRYGPIRKHFQPAVTKFMEKVREELGPEYYDDISGWRASFESDWVATLCRILLRMRGFHHGGALLMTPDTIYDGLNIKYNLQYDRLRTALVHRAVHQIQKDVAESEIIDILDDPEAETMPLVLHLDESISSDELNDSNSEIDGAIWFVSLLSRVDGLVLLNFDLEVKAFGVEILGSLAESVVTQGFWQVAKCVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WZ7</accession>
    <name>Q39WZ7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gcvH</name>
        <name evidence="6" type="synonym">larG</name>
        <name evidence="6" type="ordered locus">Gmet_0985</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514380.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0985"/>
    <dbReference type="EnsemblBacteria" id="ABB31227">
        <property type="protein sequence ID" value="ABB31227"/>
        <property type="gene ID" value="Gmet_0985"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0985"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_0_7"/>
    <dbReference type="OMA" id="EHEWLSG"/>
    <dbReference type="OrthoDB" id="1773485at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="132" mass="14470" checksum="B6D7C07A6F3FA464" modified="2005-11-22" version="1">MDFPDELKYSKEHVWVRVEGDRAVIGITDYAQESLGTISAVELPAVGDELEQDDSFGSVEARKCLAELYAPVSGTVAEVNDELESAPEILNDDPYDGGWIAVVELADPEELKSLLSAEDYAESVSQEDEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X37</accession>
    <name>Q39X37_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response receiver-modulated nucleotide cyclase, GGDEF-related domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0945</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514428.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0945"/>
    <dbReference type="EnsemblBacteria" id="ABB31187">
        <property type="protein sequence ID" value="ABB31187"/>
        <property type="gene ID" value="Gmet_0945"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0945"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_7_7"/>
    <dbReference type="OMA" id="IVPHFYD"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="152"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="305" mass="33970" checksum="6EAB6C81FAB75142" modified="2005-11-22" version="1">MGTNLRIIVVTSPSGGDGSLELRLQSKGYQVVTLDNPPSVMGLIYSDPPDVVLIDLATPDQTLLGIIHSLKDDFFFSTIPVIGMIPEWAAEGFDWEEYPLDDFVTTPLSYRDLFTRIVLSLRRLRRVFDNNPLTRLPGNTSIQRAIEHAVGKPMGVCYVDINHFKQYNDVYGFAHGDEVIRMVARIIANAVKEAGEGFAGHIGGDDFVFIVPLEQAEAVSERIIANFTAVVSELFNEEEKARGFYVAHDRKGNEERVPLMGVAISIVPMDSPKIGHYAKVAEVAAELKKMAKKSHRSCYVMDRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X46</accession>
    <name>Q39X46_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HNH endonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0936</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2012-09" db="PDB data bank">
            <title>Northeast Structural Genomics Consortium Target GmR87.</title>
            <authorList>
                <person name="Kuzin A."/>
                <person name="Chen Y."/>
                <person name="Seetharaman J."/>
                <person name="Fang F."/>
                <person name="Xiao R."/>
                <person name="Cunningham K."/>
                <person name="Ma L."/>
                <person name="Owens L."/>
                <person name="Chen C.X."/>
                <person name="Everett J.K."/>
                <person name="Acton T.B."/>
                <person name="Montelione G.T."/>
                <person name="Hunt J.F."/>
                <person name="Tong L."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH ZINC</scope>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514419.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="4H9D">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.60 A"/>
        <property type="chains" value="A/B/C=1-104"/>
    </dbReference>
    <dbReference type="PDBsum" id="4H9D"/>
    <dbReference type="SMR" id="Q39X46"/>
    <dbReference type="STRING" id="269799.Gmet_0936"/>
    <dbReference type="DNASU" id="3740092"/>
    <dbReference type="EnsemblBacteria" id="ABB31178">
        <property type="protein sequence ID" value="ABB31178"/>
        <property type="gene ID" value="Gmet_0936"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0936"/>
    <dbReference type="eggNOG" id="COG1403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158450_0_0_7"/>
    <dbReference type="OMA" id="CKECNNK"/>
    <dbReference type="OrthoDB" id="1843957at2"/>
    <dbReference type="EvolutionaryTrace" id="Q39X46"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029471">
        <property type="entry name" value="HNH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14279">
        <property type="entry name" value="HNH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00507">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="HNHc" evidence="1">
        <location>
            <begin position="27"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="4H9D"/>
        </source>
    </evidence>
    <sequence length="104" mass="12199" checksum="CF485E6CB6C4F6BA" modified="2005-11-22" version="1">MNYFIVEVSEQEVKREKEKARELRRSQWWKNRIARGICHYCGEIFPPEELTMDHLVPVVRGGKSTRGNVVPACKECNNRKKYLLPVEWEEYLDSLESEPSDGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X96</accession>
    <name>Q39X96_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">arnB</name>
        <name evidence="4" type="ordered locus">Gmet_0886</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31128.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513033.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0886"/>
    <dbReference type="EnsemblBacteria" id="ABB31128">
        <property type="protein sequence ID" value="ABB31128"/>
        <property type="gene ID" value="Gmet_0886"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0886"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_0_3_7"/>
    <dbReference type="OMA" id="IVNHGMY"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31128.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="387" mass="42705" checksum="54F64F7C5DF2B2A6" modified="2012-10-31" version="2">MRSEFLPFSKPTIDDDEINEVVASLKSGWITTGPKVKRFEEAFKAYVGASYAVPLSSATAGLHLTLIALKLDEGDEIITTPMTFASTVSMIVLCGAKPVLVDIEPGTLNIDAAKIREKITPRTKAIIPVHFAGQSCDMDPIFALAKEFGLTVIEDAAHAAGTEYKGKRIGSLDSISIFSFHPNKNITTGEGGMVCTADETLAEEISLLKFHGMSREAWKRFAASGTPNYDILLPGYKYNMMDIQAAIGIHQLPKLDGFIEKRREIAEFYKAAFADVHELATPALAPYDQRHAWHLYTPLVRVEKLTIDRDTFMAELKNLNIGTGLHYKAIHHHAWYRENMPVPAGSLPNADYASDRILSLPLFPAMTMDDARDVVAAVKDVIARNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XD2</accession>
    <name>Q39XD2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cell division protein, SpoIID family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31092.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512995.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0850"/>
    <dbReference type="EnsemblBacteria" id="ABB31092">
        <property type="protein sequence ID" value="ABB31092"/>
        <property type="gene ID" value="Gmet_0850"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0850"/>
    <dbReference type="eggNOG" id="COG2385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021203_3_3_7"/>
    <dbReference type="OMA" id="LCQWGAK"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013486">
        <property type="entry name" value="SpoIID/LytB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013693">
        <property type="entry name" value="SpoIID/LytB_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30032:SF4">
        <property type="entry name" value="PTHR30032:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08486">
        <property type="entry name" value="SpoIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02669">
        <property type="entry name" value="SpoIID_LytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoIID" evidence="1">
        <location>
            <begin position="116"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31092.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="384" mass="41316" checksum="FB2E91CA6E413D30" modified="2012-10-31" version="2">MSEGLSVTVRFLFAIAALLLLLAGDGSAATLPRQEAVRVAIIKGVDSVRIDGDGVLATDGRGEPLRLTLPAQVRRVGGSLSVGGQTVARLTVTSPLVIQVNGKRYRGTIEVSPADRGILVVNDLPLEDYLVGLINCEISSQWPIEAVKAQAVVARTYASYQKRARANAPYHLESSVLDQVYDGCEIEDSRAARGVRETAGEILTYGGQPIQAFYHSNCGGRTEVAENVWGVRLPYLKSVDCAYCSTNPSIRWEYAISLKKLESLLRGSGTHVSGLRDVREGKRNESGRLIDLALVSGGGTTTVTAVNFRKIVGYTAIKSTNFTVRVTSDLVRFTGTGYGHGVGLCQWGAKQRASDGFTYREILAYYYPGALLSKLPVGQGVDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XF2</accession>
    <name>Q39XF2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Robl_LC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512974.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0830"/>
    <dbReference type="EnsemblBacteria" id="ABB31072">
        <property type="protein sequence ID" value="ABB31072"/>
        <property type="gene ID" value="Gmet_0830"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0830"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107530_0_0_7"/>
    <dbReference type="OMA" id="STANTFW"/>
    <dbReference type="OrthoDB" id="1627608at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="224" mass="23945" checksum="84B16A1138F40FF1" modified="2005-11-22" version="1">MDEVLQQLNAVPGVIGSLVCGRDGDPIACAFPPLFDSAIIEGVTAAVTDSARGVFDATGPAELLDFRYGDGRVIIKPLQDAFVLLLCTKKVNLGVLAISLNVAKIKLESHLVARGERQKPAAAAPDLLELAVCHLADGTKGSSFEQFGMAALTPATARQVSSFYKREAFKKLKITNRVNGIFDIFPVMIVNESDSSYDGKIILCKSIEKKLEALQGDGLLVEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XH1</accession>
    <name>Q39XH1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux pump, RND family, outer membrane lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0811</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0811"/>
    <dbReference type="EnsemblBacteria" id="ABB31053">
        <property type="protein sequence ID" value="ABB31053"/>
        <property type="gene ID" value="Gmet_0811"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0811"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_13_3_7"/>
    <dbReference type="OMA" id="AANQDYY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010131">
        <property type="entry name" value="RND_efflux_OM_lipoprot_NodT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01845">
        <property type="entry name" value="outer_NodT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="517" mass="56240" checksum="408DAC87256664AC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XJ4</accession>
    <name>Q39XJ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0788</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513533.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0788"/>
    <dbReference type="EnsemblBacteria" id="ABB31030">
        <property type="protein sequence ID" value="ABB31030"/>
        <property type="gene ID" value="Gmet_0788"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0788"/>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045686_1_1_7"/>
    <dbReference type="OMA" id="NYLVFPK"/>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="257" mass="28035" checksum="531EB2DE6022FEE2" modified="2005-11-22" version="1">MLRTFLEKLGAVTIFIFREMGRMLIFLVMALVNIIIRPGRPFHIFKQIHFIGTKSLFVITLTASFTGMVLGLQGYYTLAKFGSEGMLGSAVALSLIRELGPVLTALMVVGRAGSAITAEIGIMKITEQIDAMKTMALEPFKYLISPKIVGALVAVPLLCAIFDVVGIYGGYLVGVKLLGVNPGAYFHEMERSVEWKDVWSGFVKSISFGGILAWVCCYKGYHASHGAEGVSRATTEAVVMSSVLVLVWDYFLTSVML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XK2</accession>
    <name>Q39XK2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">cheBR</name>
        <name evidence="12" type="ordered locus">Gmet_0780</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365723.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0780"/>
    <dbReference type="EnsemblBacteria" id="ABB31022">
        <property type="protein sequence ID" value="ABB31022"/>
        <property type="gene ID" value="Gmet_0780"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0780"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000892_0_2_7"/>
    <dbReference type="OMA" id="SHELKHP"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="10">
        <location>
            <begin position="30"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CheR-type methyltransferase" evidence="11">
        <location>
            <begin position="237"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="825"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="661"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="69"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB31022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="887" mass="99295" checksum="BEFDDCF8C1DC30BE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XN0</accession>
    <name>Q39XN0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Epoxyqueuosine reductase QueH</fullName>
            <ecNumber evidence="5 12">1.17.99.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 12">Queuosine biosynthesis protein QueH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">queH</name>
        <name evidence="13" type="ordered locus">Gmet_0752</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + epoxyqueuosine(34) in tRNA = A + H2O + queuosine(34) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:32159"/>
            <dbReference type="Rhea" id="RHEA-COMP:10345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82831"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="1.17.99.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the QueH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.99.6" evidence="5 12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513497.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0752"/>
    <dbReference type="DNASU" id="3739890"/>
    <dbReference type="EnsemblBacteria" id="ABB30994">
        <property type="protein sequence ID" value="ABB30994"/>
        <property type="gene ID" value="Gmet_0752"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0752"/>
    <dbReference type="eggNOG" id="COG1636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088177_1_1_7"/>
    <dbReference type="OMA" id="PNIHPYT"/>
    <dbReference type="OrthoDB" id="1078220at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052693">
        <property type="term" value="F:epoxyqueuosine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02089">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003828">
        <property type="entry name" value="QueH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36701">
        <property type="entry name" value="PTHR36701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02677">
        <property type="entry name" value="QueH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0819">tRNA processing</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="12">
        <location>
            <begin position="163"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB30994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="180" mass="21062" checksum="E11A0B7E653D0DD4" modified="2005-11-22" version="1">MKILLHMCCGPCAAYPVEQLRGQGAAVTGYWFNHNIHPYQEYMRRRDTVRAYAEKVRLDVIWRDEYRLEEFLAAVAQNPDDRCFYCYFSRLDAVAAAAAAGGFDAFSSTLLYSRYQKHDAIRDCAERAAERHGVAFHYDDYRRGWQEGIRLSKELGLYRQQYCGCIYSEKERYHPREGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XV9</accession>
    <name>Q39XV9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrogenase molybdenum-iron cofactor biosynthesis protein NifB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">nifB</name>
        <name evidence="3" type="ordered locus">Gmet_0673</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514064.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0673"/>
    <dbReference type="EnsemblBacteria" id="ABB30915">
        <property type="protein sequence ID" value="ABB30915"/>
        <property type="gene ID" value="Gmet_0673"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0673"/>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104194_3_2_7"/>
    <dbReference type="OMA" id="CAQIGQA"/>
    <dbReference type="OrthoDB" id="1995095at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00852">
        <property type="entry name" value="NifB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034165">
        <property type="entry name" value="NifB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="2">
        <location>
            <begin position="9"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="109" mass="12024" checksum="36A287ABD17A5E07" modified="2005-11-22" version="1">MLIAVASKDGREINQHFGHAERFLIYEVEGDDAKLVDEKKVERYCSYDVDHPLRSHILEAIACALAGCRAVVCAQIGQAPQMAMERLGIDAYVADGLIKPTLVEIARVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y37</accession>
    <name>Q39Y37_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ResC/HemX-like cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512292.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0594"/>
    <dbReference type="EnsemblBacteria" id="ABB30837">
        <property type="protein sequence ID" value="ABB30837"/>
        <property type="gene ID" value="Gmet_0594"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0594"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049710_2_2_7"/>
    <dbReference type="OMA" id="SVWLILH"/>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="77"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="275" mass="31453" checksum="32596AFE1B3DA50E" modified="2005-11-22" version="1">MESSFSSITIIHWAAVVIYVLATIFNVAGLIFRKERATGISYLLVGAGLLVHGIGILWWWKIVGHGPYIGRFEVLSSQAWMGLFLFMVFAHFLPKIRPASILVFPAAFLMIAVGIFFEPQVKMLPPTLRSVWLILHVTFYKISVCTLLVALAFSIFFILRKRTGIQWLTRLPDMETMDILAFRFAGFSFTFWAIAMLAGSIWAYESWGRFWGWDPIETWSLITWVAFGIYLHLRRFFGLKGEAAAYLYILCFLLSVLSLFFTPLIGGSVHSEYFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y95</accession>
    <name>Q39Y95_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Menaquinol oxidoreductase complex Cbc6, lipoprotein cytochrome c subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cbcM</name>
        <name evidence="1" type="ordered locus">Gmet_0536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30779.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0536"/>
    <dbReference type="EnsemblBacteria" id="ABB30779">
        <property type="protein sequence ID" value="ABB30779"/>
        <property type="gene ID" value="Gmet_0536"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0536"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023565_0_0_7"/>
    <dbReference type="OMA" id="IDCHTSR"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30779.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="615" mass="68057" checksum="85952455CA92C3DD" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YA1</accession>
    <name>Q39YA1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512226.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0530"/>
    <dbReference type="DNASU" id="3738051"/>
    <dbReference type="EnsemblBacteria" id="ABB30773">
        <property type="protein sequence ID" value="ABB30773"/>
        <property type="gene ID" value="Gmet_0530"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0530"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_7"/>
    <dbReference type="OMA" id="GCCARRF"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="318" mass="35184" checksum="48FC756F9E23888C" modified="2005-11-22" version="1">MDITLFKTLLKVAAIGNISKAAAVLCVTQSAVSRRLKQLEDHIGKPLLIRSGNAVRPTEAGQFVLAKAQQIVDLESQIVDKLNVNEPKQRISLCCTPAFGIGRLPSIVSAFMADNAESADLNFVFNMPEQALEGIENGRFDLAIIEHCDDLNMAGHRGYPLPDDEMIFLSAPSLGIDSPAPSIEQLFDKRLYLKNEQGCARRFLDKNLALTGHSITEFANIIYFDDLQFIMREVLAGKGISFVPIGLVVDELCRHTLMAHRIADFDHFYPRTIILGRRAPSPLLLSFINTIYIAFGMPCPSIFHTEAPFPPEGFPESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YC7</accession>
    <name>Q39YC7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylenetetrahydrofolate reductase (NAD(P)H)</fullName>
            <ecNumber evidence="5">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">metF-2</name>
        <name evidence="13" type="ordered locus">Gmet_0504</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512200.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0504"/>
    <dbReference type="EnsemblBacteria" id="ABB30747">
        <property type="protein sequence ID" value="ABB30747"/>
        <property type="gene ID" value="Gmet_0504"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0504"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453272_0_0_7"/>
    <dbReference type="OMA" id="TNTYAAN"/>
    <dbReference type="OrthoDB" id="118138at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004489">
        <property type="term" value="F:methylenetetrahydrofolate reductase (NAD(P)H) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="12">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB30747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="605" mass="64560" checksum="C1135904DFF984D3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YD8</accession>
    <name>Q39YD8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Divalent manganese/zinc ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ABC-3 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512189.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0493"/>
    <dbReference type="EnsemblBacteria" id="ABB30736">
        <property type="protein sequence ID" value="ABB30736"/>
        <property type="gene ID" value="Gmet_0493"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0493"/>
    <dbReference type="eggNOG" id="COG1108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028808_3_1_7"/>
    <dbReference type="OMA" id="LCIFWRA"/>
    <dbReference type="OrthoDB" id="1421296at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037294">
        <property type="entry name" value="ABC_BtuC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001626">
        <property type="entry name" value="ABC_TroCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30477">
        <property type="entry name" value="PTHR30477"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00950">
        <property type="entry name" value="ABC-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81345">
        <property type="entry name" value="SSF81345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="272" mass="28681" checksum="023596BFE890CB65" modified="2005-11-22" version="1">MTFLDIFQYGFLLRALAAGSLIAALCAVLGVFLVLRRLSLIGDGLAHVTFGSVALALFLRFQSVYATVAAIPAVLLAALGILRLAERARIYGDAAIGIVSSLGVATGILLASMAGGFNVDLFSYLFGNILSISPFELGQTAVLFVIVCLTVLLCYHDLFAIAFDEELARTSGIRVDRINAVLVLLTALTVVLAMKVVGIMLISALLILPAVTSLQIARGFRTAILLAVLLGVLSVVAGIVISFLANLPAGATIILVNFTLFLVSFGLRKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YM9</accession>
    <name>Q39YM9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512374.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0402"/>
    <dbReference type="EnsemblBacteria" id="ABB30645">
        <property type="protein sequence ID" value="ABB30645"/>
        <property type="gene ID" value="Gmet_0402"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0402"/>
    <dbReference type="eggNOG" id="ENOG5032Z37">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157822_0_0_7"/>
    <dbReference type="OMA" id="YTWILDE"/>
    <dbReference type="OrthoDB" id="1865287at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="118" mass="12996" checksum="9E169CDDF4393D69" modified="2005-11-22" version="1">MATTINDLVLVHIDSKPGFYARIEDISPDVKAGWWRVRLLVLTVPLEIYTWILEEAQINGAPFTMGGTPIRMEKVVSPVLGDSASAPSPPQPFPTPQEEKDQGKGGKVVSLLDRKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YR3</accession>
    <name>Q39YR3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0368</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512340.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0368"/>
    <dbReference type="EnsemblBacteria" id="ABB30611">
        <property type="protein sequence ID" value="ABB30611"/>
        <property type="gene ID" value="Gmet_0368"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0368"/>
    <dbReference type="HOGENOM" id="CLU_2316285_0_0_7"/>
    <dbReference type="OMA" id="MFFNCLA"/>
    <dbReference type="OrthoDB" id="2083359at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="99" mass="11052" checksum="6A5B5F244AA3053C" modified="2005-11-22" version="1">MTEYPLPLFILNLILTLVDAAIGYHVAPMIMRRFTPDPETAELSVRGMRTMLGGVVALYMFFNCLGYFRQNGVMLMVVTAVVVVDMVAQLVVRRKIGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YU9</accession>
    <name>Q39YU9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Respiratory nitrate reductase, cytochrome b gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">narI-1</name>
        <name evidence="15" type="ordered locus">Gmet_0332</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512304.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0332"/>
    <dbReference type="EnsemblBacteria" id="ABB30575">
        <property type="protein sequence ID" value="ABB30575"/>
        <property type="gene ID" value="Gmet_0332"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0332"/>
    <dbReference type="eggNOG" id="COG2181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092378_0_0_7"/>
    <dbReference type="OMA" id="MVSGGFF"/>
    <dbReference type="OrthoDB" id="1873056at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="7"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB30575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="231" mass="26505" checksum="4BF5D33E8EE1868E" modified="2005-11-22" version="1">MLNTVLNTFIFVALPYVALAMLIVVTPYRYYSNRLTWSAYSTQFLERKTLYWGANPWHYGIIPIILAHTLGVVAPGAMKSLLGNVEVLVFLESVGLGLGLFALFGCVVLLLRRVNAPMLKRVTYPADWVLLILLTFQTLTGVYISLFMRWGSQWYLHTAVPYLYSLLYFNPKVEYLADFPLILKLHAAGAFLIVALLPFTKLVHLLYWPLDFLKDPPILYRWRSRPEGKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YW3</accession>
    <name>Q39YW3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514028.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0317"/>
    <dbReference type="EnsemblBacteria" id="ABB30561">
        <property type="protein sequence ID" value="ABB30561"/>
        <property type="gene ID" value="Gmet_0317"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0317"/>
    <dbReference type="eggNOG" id="COG2944">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144725_3_0_7"/>
    <dbReference type="OMA" id="IKSWETG"/>
    <dbReference type="OrthoDB" id="1933795at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="103" mass="11306" checksum="768FE034A985998B" modified="2005-11-22" version="1">MSLDEKELLARDAKRNIGEELLQAVRDIKAGKVGRVSTLEISPIAAARQKIGLSQREFAKMLGVSLRTLQEWEQGRRTPSGAAKSLITIAIKKPEVIKELLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z23</accession>
    <name>Q39Z23_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase, AMP-forming</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513573.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0256"/>
    <dbReference type="EnsemblBacteria" id="ABB30501">
        <property type="protein sequence ID" value="ABB30501"/>
        <property type="gene ID" value="Gmet_0256"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0256"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_5_7"/>
    <dbReference type="OMA" id="DFGGWKI"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="30"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="455"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="548" mass="61124" checksum="6D9CD0F69D9B8CDB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z33</accession>
    <name>Q39Z33_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress response kinase A</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Serine/threonine-protein kinase SrkA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rdoA</name>
        <name evidence="2" type="synonym">srkA</name>
        <name evidence="4" type="ordered locus">Gmet_0246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SrkA/RdoA protein kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513562.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0246"/>
    <dbReference type="EnsemblBacteria" id="ABB30491">
        <property type="protein sequence ID" value="ABB30491"/>
        <property type="gene ID" value="Gmet_0246"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0246"/>
    <dbReference type="eggNOG" id="COG2334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054715_0_0_7"/>
    <dbReference type="OMA" id="MHYSAWL"/>
    <dbReference type="OrthoDB" id="1003984at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01497">
        <property type="entry name" value="SrkA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032882">
        <property type="entry name" value="SrkA/RdoA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39573">
        <property type="entry name" value="PTHR39573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1 2" id="KW-0346">Stress response</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="APH" evidence="3">
        <location>
            <begin position="35"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="ATP" evidence="2">
        <location>
            <position position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="328" mass="37616" checksum="637B509804DD39F0" modified="2005-11-22" version="1">MPHRTHPFSTLTPAFIMDAVESQGFACDCRTLALNSYENRVYQVGIEEGEPLVAKFYRPGRWTDEQIVEEHEFCAELAGHELPVVAPWRNAAGHTLFHHGGFRFALYPRQGGRAPEFDNLDNLLVLGRMLGRMHRIGAVTPFAHRPTLDSQSFGRESVALIRDRFIPPDLRESYAAVTGMLLETVDATFAEMGAVRYLRTHGDCHAGNILWRGDAPHFVDFDDARMAPAVQDLWMMLSGDRPRKLAQLDSLLEGYTEFNEFDSRELRLIEPLRALRVLHYSAWLARRWEDPIFPATFPWFNTPRYWNDQIIELREQVAALTEPPLELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z34</accession>
    <name>Q39Z34_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513561.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0245"/>
    <dbReference type="EnsemblBacteria" id="ABB30490">
        <property type="protein sequence ID" value="ABB30490"/>
        <property type="gene ID" value="Gmet_0245"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0245"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_518499_0_0_7"/>
    <dbReference type="OMA" id="PWYGFAR"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elp3" evidence="1">
        <location>
            <begin position="249"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="502" mass="55437" checksum="7846B0B34B5C7C61" modified="2005-11-22" version="1">MLLIHPPVAKPGEPPAGIARLAGALRVNGLPCRVLDANLEGLLWLMEQPEPGTDTWTRRAVKGRGGHLAALRERQTYRSPDRYVRAVMDLNRLLAVAGKENGATVGLADYEQADFSPVSSAGLLRAAAEPERNPFFPWFSRRLPELLDDIRVVGISLNYLSQAVTTFALIGFIRQRFPDLTVVLGGGLVTSWLRRPAWRNPFGGLVDHMIAGPGEEPLLALLGARPECRQPPLPAYDLLPLAGYLSPGLVLPYSAASGCWWNRCSFCPERAEGNPYRPIPASQALDELRTLADRYRPALIHLLDNAVSPSLLRSLANTPPGAPWYGFARIDDTLADYDFCRALRRSGCVMLKLGLESGDQGVLDRLHKGIDLGTAGRVLENLRLAGIAVYGYLLFGTPAEAEEDARRTLDFVVRHREAITFLNLAVFNMPAFGDEAIDHGTEPFYGGDLPLYTGFRHPRGWGRREVRRFLDREFTRHPAVAEILRRDPPLFTSNHAPFFAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZA2</accession>
    <name>Q39ZA2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365631.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0176"/>
    <dbReference type="EnsemblBacteria" id="ABB30422">
        <property type="protein sequence ID" value="ABB30422"/>
        <property type="gene ID" value="Gmet_0176"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0176"/>
    <dbReference type="eggNOG" id="ENOG502ZM4N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1041152_0_0_7"/>
    <dbReference type="OMA" id="CGKEELF"/>
    <dbReference type="OrthoDB" id="1377433at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="264" mass="28783" checksum="682C8071AA484D74" modified="2005-11-22" version="1">MERSAKSTHLDPELSRRLHRALTCGKEELFEAILDSSPEVLRAALRNPALDGNHLLALLGRRDLTEDLLRTVAGLDTVAGNHNLTVALVQNPATPAGVALSLLPRLYLFELVTLSELPGTTPDQRLAAERAIVQRLPTTPLGNRITLARRASASVLDALMKEGDVRVVEPCLANPRLKEASVFQLVSSARSSTEAIAAVARHQRWASRPNLKIAMIKNPRTPSTVFVSLLAGAPAMELRNLAVSGRLGQEQKRLIGEELRRRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZJ6</accession>
    <name>Q39ZJ6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514203.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0079"/>
    <dbReference type="EnsemblBacteria" id="ABB30328">
        <property type="protein sequence ID" value="ABB30328"/>
        <property type="gene ID" value="Gmet_0079"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0079"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_939289_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="296" mass="33335" checksum="05D026425766B343" modified="2005-11-22" version="1">MAKTIDEIINKHYNEAAGGIVDKVPSALKRGEGTEREFYMLKIDLVDSTLFTWTRTHKTYLKLAHTFLSSVDEISREFGADDDQVEYVGDSIIAYFRADKVNALSVLYAAYYCRIAALQMKSLDATFSKYHFLTKTILHHGKLILAKIGPRGDTFVTAIGPALHRACKMESRVSPGQSRVSKEFREKLLGREKLLLKPNYKETQVPKVPEFQPATHNLSNLLYPSSSPATLLGMSPSDLAQTTENLLAGAIAPRRGLMEFARTTPSAQTKFEVKRELIDFSVKWDDVARYIALQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZS0</accession>
    <name>Q39ZS0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">DNA gyrase subunit B</fullName>
            <ecNumber evidence="4 12">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">gyrB</name>
        <name evidence="14" type="ordered locus">Gmet_0004</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type II topoisomerase GyrB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the type II topoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4 12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513723.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0004"/>
    <dbReference type="EnsemblBacteria" id="ABB30254">
        <property type="protein sequence ID" value="ABB30254"/>
        <property type="gene ID" value="Gmet_0004"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0004"/>
    <dbReference type="eggNOG" id="COG0187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006146_4_1_7"/>
    <dbReference type="OMA" id="LWETTMH"/>
    <dbReference type="OrthoDB" id="205481at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03366">
        <property type="entry name" value="TOPRIM_TopoIIA_GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01898">
        <property type="entry name" value="GyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002288">
        <property type="entry name" value="DNA_gyrase_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011557">
        <property type="entry name" value="GyrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034160">
        <property type="entry name" value="TOPRIM_GyrB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00986">
        <property type="entry name" value="DNA_gyraseB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01059">
        <property type="entry name" value="gyrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="13">
        <location>
            <begin position="421"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="795" mass="88597" checksum="E7E8AD600D06AAEF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZS3</accession>
    <name>DNAA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chromosomal replication initiator protein DnaA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaA</name>
        <name type="ordered locus">Gmet_0001</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513720.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZS3"/>
    <dbReference type="SMR" id="Q39ZS3"/>
    <dbReference type="STRING" id="269799.Gmet_0001"/>
    <dbReference type="EnsemblBacteria" id="ABB30251">
        <property type="protein sequence ID" value="ABB30251"/>
        <property type="gene ID" value="Gmet_0001"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0001"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026910_3_1_7"/>
    <dbReference type="OMA" id="REFNPLF"/>
    <dbReference type="OrthoDB" id="219876at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06571">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1750.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00377">
        <property type="entry name" value="DnaA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018312">
        <property type="entry name" value="Chromosome_initiator_DnaA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013159">
        <property type="entry name" value="DnaA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024633">
        <property type="entry name" value="DnaA_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038454">
        <property type="entry name" value="DnaA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010921">
        <property type="entry name" value="Trp_repressor/repl_initiator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08299">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11638">
        <property type="entry name" value="DnaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00760">
        <property type="entry name" value="Bac_DnaA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48295">
        <property type="entry name" value="SSF48295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00362">
        <property type="entry name" value="DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01008">
        <property type="entry name" value="DNAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000048649" description="Chromosomal replication initiator protein DnaA">
        <location>
            <begin position="1"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="155"/>
            <end position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="450" mass="50943" checksum="2A910CF1ACB9A391" modified="2005-11-22" version="1">MEDVWLQAQSNLAKVLTHQTFTTWIEPIRFAGAHKNTLLLEAPNQFIRDRVRESYLPMILESVRSLTDSHFQVELQVAARQQEKTAKSPRKSHTEDELGPVESEKCAPAEFSTNLNAKYTFDTFVCGGSNQFAHAAALSVANNPAGKYNPLFIYGGVGLGKTHLLTAIGNQVLTKNRKARVCFYTSEKFMNELINCLRYQKMEQFRNKFRKMDLLLIDDIQFIAGKERTQEEFFHTFNALYESHKQIVVTSDKFPKDIPGLEERLRSRFEWGLIADIQPPDTETKVAILSKKADSDGIRLPDDVALFLASSASTNVRELEGMLIRLGAVASLTGKNITLDMAREVLKDIIVDKTKEVTVEMIQKYVADHFNIKVAELKSDKRLKALVVPRQIAIYLCRDLTKASYPDIGEKFGGKDHSTIIHSVKKVDKLLSQDFELKSTIETLRKGLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>J7LWD9</accession>
    <name>J7LWD9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3629"/>
    <dbReference type="EnsemblBacteria" id="AFR42845">
        <property type="protein sequence ID" value="AFR42845"/>
        <property type="gene ID" value="Gmet_3629"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3629"/>
    <dbReference type="HOGENOM" id="CLU_1978336_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="126" mass="14399" checksum="3A82682AADAF1562" modified="2012-10-31" version="1">MSQVSIAVHSSLRSFPREILFSSCRYVPFTNPARLQFTAPRSCVPIYALMFGDYSLPMLVDNPDGQWFYAKFTCFIAQGNRTINSVLIFAYLHLLALVLQEIMSENRKMATMGGRPRVNFGDFAMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYH8</accession>
    <name>J7LYH8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3625"/>
    <dbReference type="EnsemblBacteria" id="AFR42843">
        <property type="protein sequence ID" value="AFR42843"/>
        <property type="gene ID" value="Gmet_3625"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3625"/>
    <dbReference type="HOGENOM" id="CLU_3216769_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="44" mass="5045" checksum="1E26A26F90145A04" modified="2012-10-31" version="1">MPLKSLFSTFPACRILCLHSIPAFVSCQTSTFRCPPHLRKFYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEM4</accession>
    <name>J9JEM4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3649"/>
    <dbReference type="EnsemblBacteria" id="AFR42801">
        <property type="protein sequence ID" value="AFR42801"/>
        <property type="gene ID" value="Gmet_3649"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3649"/>
    <dbReference type="HOGENOM" id="CLU_222182_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="20" mass="2271" checksum="F944FB292D980583" modified="2012-10-31" version="1">MKKRSYVKPRIVGSANVHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEP7</accession>
    <name>J9JEP7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_A3643</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="3">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="3">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="AFR42863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514722.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3643"/>
    <dbReference type="EnsemblBacteria" id="AFR42863">
        <property type="protein sequence ID" value="AFR42863"/>
        <property type="gene ID" value="Gmet_A3643"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3643"/>
    <dbReference type="HOGENOM" id="CLU_2915956_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003824253" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="61" mass="6496" checksum="1E6D1D6DB457A758" modified="2012-10-31" version="1">MKKQVIMGLVVVVMGAMLVAGCNKAPEGYTADGQPAKALKKGELPKAGPEKNMLDYYKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PQ3</accession>
    <name>Q39PQ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_A3566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33771.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3566"/>
    <dbReference type="EnsemblBacteria" id="ABB33771">
        <property type="protein sequence ID" value="ABB33771"/>
        <property type="gene ID" value="Gmet_A3566"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3566"/>
    <dbReference type="HOGENOM" id="CLU_3061952_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33771.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="53" mass="5976" checksum="2BDC8D79C3779B88" modified="2012-10-31" version="2">MSVSTITEIIEAEEEGHKAYIFKCKNGKTYLETSLGYTEDQLKNKKTLYSIAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PQ7</accession>
    <name>YIDD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative membrane protein insertion efficiency factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_3562</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Could be involved in insertion of integral membrane proteins into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0161 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513718.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39PQ7"/>
    <dbReference type="STRING" id="269799.Gmet_3562"/>
    <dbReference type="EnsemblBacteria" id="ABB33767">
        <property type="protein sequence ID" value="ABB33767"/>
        <property type="gene ID" value="Gmet_3562"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3562"/>
    <dbReference type="eggNOG" id="COG0759">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144811_6_0_7"/>
    <dbReference type="OMA" id="QPTCSHY"/>
    <dbReference type="OrthoDB" id="1912220at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00386">
        <property type="entry name" value="UPF0161_YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002696">
        <property type="entry name" value="Membr_insert_effic_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33383">
        <property type="entry name" value="PTHR33383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01809">
        <property type="entry name" value="YidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01234">
        <property type="entry name" value="Haemolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00278">
        <property type="entry name" value="TIGR00278"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000253111" description="Putative membrane protein insertion efficiency factor">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00386"/>
        </source>
    </evidence>
    <sequence length="69" mass="7963" checksum="FB90AB770F12ADB7" modified="2005-11-22" version="1">MLKILIKIIGIYQRYLSPLTGPTCRFYPSCSTYAKESLMRHGLLKGLWYSAVRIMKCHPYHPGGYDPVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PS0</accession>
    <name>Q39PS0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidylprolyl cis-trans isomerase, PpiC-type, SurA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3549</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366203.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3549"/>
    <dbReference type="EnsemblBacteria" id="ABB33754">
        <property type="protein sequence ID" value="ABB33754"/>
        <property type="gene ID" value="Gmet_3549"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3549"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_5_0_7"/>
    <dbReference type="OMA" id="QVRANMG"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015391">
        <property type="entry name" value="SurA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09312">
        <property type="entry name" value="SurA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004222967" evidence="3">
        <location>
            <begin position="23"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="4">
        <location>
            <begin position="173"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="333" mass="37696" checksum="32C4D5045CF2826B" modified="2005-11-22" version="1">MIKTLITATLVLIATLPSPSHAEVVNRILAVVNDEIITSYAVEKEKATILKEAERQQPPPPPESLVHLDETALNRLIDKKLVEQKVRELDIKVSEEEVRQAIEDVKRQNKLSQESLVSALANQGLSFDQYKVQIREQLERLRLVSQEVRSKIQVGEREMREYYEANPGRFGGEENFRARNIYFKLDEKMPADQVKKIMTTALTVLHEARDGKDFAELARQHSDDPAAKNTGGDLGTFRKGDILPEFEESLIKMKPGEVSDLIYVSGGLHIVKLEARFAGTPKPFEQVKAEVEDILYRKKSEERFNQWVADLRKGAAIEIRQETGTGDRGPAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q45</accession>
    <name>Q39Q45_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell polarity determinant GTPase MglA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mglA</name>
        <name evidence="3" type="ordered locus">Gmet_3417</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366190.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3417"/>
    <dbReference type="EnsemblBacteria" id="ABB33629">
        <property type="protein sequence ID" value="ABB33629"/>
        <property type="gene ID" value="Gmet_3417"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3417"/>
    <dbReference type="eggNOG" id="COG1100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077110_0_0_7"/>
    <dbReference type="OMA" id="MSTINFA"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="PTHR11711"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="195" mass="22096" checksum="954856B888376CB4" modified="2005-11-22" version="1">MSFINYASREINCKIVYYGPGLCGKTTNLQHVYQKTAPEAKGKMISLATETERTLFFDFLPLALGEIRGFKTRFHLYTVPGQVFYDASRKLILKGVDGVVFVADSQEERMDANVESLDNLRFNLKEQGYDLDKLPYVIQYNKRDLPEVLSVEELRRELNPTGVPEFEACASTGEGVFETLKAVAKLILIDLKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q64</accession>
    <name>Q39Q64_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase or acyltransferase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514205.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3398"/>
    <dbReference type="ESTHER" id="geomg-q39q64">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33610">
        <property type="protein sequence ID" value="ABB33610"/>
        <property type="gene ID" value="Gmet_3398"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3398"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_26_0_7"/>
    <dbReference type="OMA" id="DSAFWGW"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="26"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="255" mass="28177" checksum="2D47AD17C5590791" modified="2005-11-22" version="1">MPFLDLGRNKQIYYELIDGEPDRPHLVFIHEGLGCAAMWKGFPHQLCRETGCPGLLYDSLGYGKSSPLDGPMNLHFLHRYALIELPAVIEQLIPEKEYVLIGHSDGGSIGLIAAAERPLRLKGLIAEAAHVFVEEKTLAGIRATVDAFRAGKLRGLFRYHGDKTEELFTAWSGAWLSDGFRPWNIEYALPSIACPVLVIQGTEDNYGTVAQVDTIMAKVPDARKVMIEGCGHVPHLERSAEVLGLMAEFVERLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QA4</accession>
    <name>Q39QA4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP synthase-associated magnesium import membrane protein AtpI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">atpI</name>
        <name evidence="7" type="ordered locus">Gmet_3358</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512584.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3358"/>
    <dbReference type="EnsemblBacteria" id="ABB33570">
        <property type="protein sequence ID" value="ABB33570"/>
        <property type="gene ID" value="Gmet_3358"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3358"/>
    <dbReference type="eggNOG" id="ENOG503291I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161276_0_0_7"/>
    <dbReference type="OMA" id="ATANFLW"/>
    <dbReference type="OrthoDB" id="2100893at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005598">
        <property type="entry name" value="ATP_synth_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03899">
        <property type="entry name" value="ATP-synt_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="127" mass="14019" checksum="24096CCE30F976D4" modified="2005-11-22" version="1">MGRTISEDRLFAAVTIGGLVLLGVLCLTGYVFWSGRFAVSILAGGILALFNFYWMRNTLKRVLNLHPRQAGSFAQFRYLLRLAFVALILYVLIVHAGIDVIGLIIGLSIFVVVIIGLSIYMLLDKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QK4</accession>
    <name>Q39QK4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512695.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3257"/>
    <dbReference type="EnsemblBacteria" id="ABB33470">
        <property type="protein sequence ID" value="ABB33470"/>
        <property type="gene ID" value="Gmet_3257"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3257"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1685267_0_0_7"/>
    <dbReference type="OMA" id="HIMKIKM"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="3"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="132" mass="15039" checksum="FBD4E360BC84C989" modified="2005-11-22" version="1">MTETIRAFFAGDEAVTAVYLFGSQATGKATAKSDIDLAVLLREKPAYDYRLRAMSDLASLLKTEVDVLVLDQCGILMQRQVLKHGIVLYERDRRARLAFEIRSRKMYFDFLPAHHLFVSKREERLLQGDGNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QL1</accession>
    <name>Q39QL1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thymidylate kinase</fullName>
            <ecNumber evidence="3 6">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tmk</name>
        <name evidence="8" type="synonym">tmk-2</name>
        <name evidence="8" type="ordered locus">Gmet_3250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3 6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512688.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3250"/>
    <dbReference type="EnsemblBacteria" id="ABB33463">
        <property type="protein sequence ID" value="ABB33463"/>
        <property type="gene ID" value="Gmet_3250"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3250"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_0_2_7"/>
    <dbReference type="OMA" id="EINADIW"/>
    <dbReference type="OrthoDB" id="1585072at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="7">
        <location>
            <begin position="9"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="211" mass="23842" checksum="8F62A97C677AB458" modified="2005-11-22" version="1">MRKGKLIVIEGISGSGQQVKAAIVGLHKALTGMKYDVVECANPDSGRAKELGIDNLLNWPFGRTPRADFMFEAAVRTEVFKNIVEPALQDDKIVLCKQSSISSLANAWVSGYTKHFDVLRHIEKLSRGFLFEDEIYPDLTLFIDVPAQEAFERIEDVLQIHHEGGIEYYEKMREFYLKEISRWHGASIAAGADRSEEEINADIWAKVQTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QP6</accession>
    <name>Q39QP6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-independent chaperone, alpha-crystallin/Hsp20 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512653.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3215"/>
    <dbReference type="EnsemblBacteria" id="ABB33428">
        <property type="protein sequence ID" value="ABB33428"/>
        <property type="gene ID" value="Gmet_3215"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3215"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_12_3_7"/>
    <dbReference type="OMA" id="QQMDEIF"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045045">
        <property type="entry name" value="RTM2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43670">
        <property type="entry name" value="PTHR43670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="17032" checksum="CA900DFB92CB3B7B" modified="2005-11-22" version="1">MAVIPKEPLDWLSLLHLQIDEVFDYIARIGGGERWGECEYLPAIDIFETPDEFTAEFELPGCDRGDLSLKLCSNTLILEGVKRDDTRDGVSYRCLERRFGRFCRAVEVPLTVDIAAVRASFRQGVLTVTFPRLADRGKIIREIPIEQGDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QY1</accession>
    <name>Q39QY1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux pump, RND family, outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514304.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3129"/>
    <dbReference type="EnsemblBacteria" id="ABB33343">
        <property type="protein sequence ID" value="ABB33343"/>
        <property type="gene ID" value="Gmet_3129"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3129"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_3_7"/>
    <dbReference type="OMA" id="VFMMKLD"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223272" evidence="3">
        <location>
            <begin position="21"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="446" mass="48982" checksum="501FF4719B355D8A" modified="2005-11-22" version="1">MKYFSAALLLLVLTPSFLLAAEPSVALNEALILALKQNHLVSGAAYEKEAAVEGAAASRSRYLPRIVAEEAFSASDLPTRVFMMKLDQGRFASSDFELGNLNTPSSYHDFRTALTLEQPLFDLGIGYGREMAEREAERMGYRFEGRREDVGFAVYGAYLGVQRAKAVLAAAEKDVEEAREHLRVATVRGHEGTGLKSDELRARTFLSEAEERTITALNDLKLAKMRLALAVGGGPGESLDIRGDVTGEAFRLNEDEIVRQAVANRRDLKGAEKGVERAAAAVGLARSAWFPTLYAAASVQMNDRDVPFGRDNDGWSAGVNLRWEVFDGMGRMHGAAKARAERDAAAQYLEQFRKEVDLQVRESILRRAEAGKRLEVARHALLAAEEGSRLVNKRFANGLATMVELLDAQSALSRARTGLVEREADHLLATARIYYTAGIFLKEMAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R10</accession>
    <name>Q39R10_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar motor switch protein FliM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fliM</name>
        <name evidence="13" type="ordered locus">Gmet_3100</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FliM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514554.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3100"/>
    <dbReference type="DNASU" id="3740875"/>
    <dbReference type="EnsemblBacteria" id="ABB33314">
        <property type="protein sequence ID" value="ABB33314"/>
        <property type="gene ID" value="Gmet_3100"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3100"/>
    <dbReference type="eggNOG" id="COG1868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052646_1_1_7"/>
    <dbReference type="OMA" id="NPQFTQI"/>
    <dbReference type="OrthoDB" id="1748746at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17908">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001689">
        <property type="entry name" value="Flag_FliM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001543">
        <property type="entry name" value="FliN-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036429">
        <property type="entry name" value="SpoA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02154">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01052">
        <property type="entry name" value="FliMN_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002888">
        <property type="entry name" value="FliM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00955">
        <property type="entry name" value="FLGMOTORFLIM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101801">
        <property type="entry name" value="SSF101801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01397">
        <property type="entry name" value="fliM_switch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliMN_C" evidence="12">
        <location>
            <begin position="251"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB33314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="327" mass="35943" checksum="64A6FF8162B2BE91" modified="2005-11-22" version="1">MEKILTKQEIEALLAAVFEGKIEPDKELAKAEATVQSYDLFSSESKGNIPNLDIIYDSFIRYQRGTLSNRLGRIVEIKKVGAASFKFDDFLHTMPSPVAMAVYKADPLKGAALIAFDSTLVFTIVDCILGGTGSSVVPTVGNRMFTSIELRLVQKIVMDVLADLEKAWAPIYATKMGFLRMEMNPRLVNIVPPEYQVVTMEMEIQIEEIIGKMIFAVPLTTIDPVREKLKNGAQVDMMAIDPQWSFRLSKELLEAPLDLSVEVGGAIISMDELLNLTPGDTIMLDTPCNSDLVVKVGGVSKFMSAPGLRHGNKAAQITTIIGKGREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R24</accession>
    <name>Q39R24_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514540.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3086"/>
    <dbReference type="DNASU" id="3740784"/>
    <dbReference type="EnsemblBacteria" id="ABB33300">
        <property type="protein sequence ID" value="ABB33300"/>
        <property type="gene ID" value="Gmet_3086"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3086"/>
    <dbReference type="eggNOG" id="COG2378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041141_4_1_7"/>
    <dbReference type="OMA" id="WHLFTWG"/>
    <dbReference type="OrthoDB" id="1654295at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028349">
        <property type="entry name" value="PafC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026881">
        <property type="entry name" value="WYL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13280">
        <property type="entry name" value="WYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016838">
        <property type="entry name" value="PafC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH_11" evidence="1">
        <location>
            <begin position="18"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="WYL" evidence="2">
        <location>
            <begin position="153"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="334" mass="37771" checksum="67AA0258114D1C88" modified="2005-11-22" version="1">MQKGKPAKKYSQAGRVHDLIRLIEARHGVTLDEMAEETGVDRRTVHRDLNVIHEAGYPLISEWLNGRKAYRFLTRFKDVPPITFTLQELMALSFFRSQLSFLDGTPFREDLDAVFRKINSVLPPRYAAHMERIADVSLPLLQGRRDYAPVAGHLESLRDALIYQYRVRLSYRGAGKGRASTYEVDPYTLVFYKGGLYLVGYAHNRQALRTFAAERITGVEVRKERFEIPADYRPEERLRGAFGIVEEEPLEVMIRFSPGVAHAVRGRVWHPSQTERSGADGSLVLSFTAGGKMEIVSWVLSYGEHAEVLAPASLRDEVGAAARRMAEKYGAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R45</accession>
    <name>Q39R45_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513624.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3064"/>
    <dbReference type="EnsemblBacteria" id="ABB33279">
        <property type="protein sequence ID" value="ABB33279"/>
        <property type="gene ID" value="Gmet_3064"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3064"/>
    <dbReference type="eggNOG" id="ENOG502ZA5F">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045653_0_0_7"/>
    <dbReference type="OMA" id="HPLKTFD"/>
    <dbReference type="OrthoDB" id="706157at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043773">
        <property type="entry name" value="DUF5716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18982">
        <property type="entry name" value="DUF5716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="474" mass="55014" checksum="6E8A29B3CFB903F7" modified="2005-11-22" version="1">MLFNKLPDEIFKPLAGANRYFFEEILLFLFRYFSDEDITNEAVFPRRGHVVREIEELLERKGRLLQIVDEEGDAEEDISNAPGPAARYIYKRLVVTGWLEEEEDGYHVNVIMPPHASLLLEALEGVAHAEKKNYGSTIASIHLQLQAIANHPEDNARAFIEVVRAARDFTRHLQNIFSGLRGFQDIITRQHNPKLALSTFFDDFVENLLISDYKSLQAENNPFRHRANVLNLLIQIEHIDSIMTALIKVYQEDKNLAPDAAREKVISDLHFIARVFRSVDRRLDAIDLYRMRLESRVAEMVRYMDRNVPDLTNRGIKLLEELGRRSLEQPDGELPALPQPPRWISHALLSHRSIRKPQRRRQPQFIELAREQELSTEVKERLRLIQDYLQRRVMSPAKVVAFIDRQMGERATFAAKDFKIESVDELVAFAFVPFLNQMKGKPVPNMPLFNIRRTGDRLDTPLLECSDFIVERKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RH2</accession>
    <name>THIG_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thiazole synthase</fullName>
            <ecNumber evidence="1">2.8.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiG</name>
        <name type="ordered locus">Gmet_2934</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + [sulfur-carrier protein ThiS]-C-terminal Gly-NH-CH2-C(O)SH = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS]-C-terminal Gly-Gly + 2 H(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:26297"/>
            <dbReference type="Rhea" id="RHEA-COMP:12908"/>
            <dbReference type="Rhea" id="RHEA-COMP:12909"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="ChEBI" id="CHEBI:77846"/>
            <dbReference type="ChEBI" id="CHEBI:90619"/>
            <dbReference type="ChEBI" id="CHEBI:90778"/>
            <dbReference type="EC" id="2.8.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer. Forms heterodimers with either ThiH or ThiS.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThiG family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512870.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RH2"/>
    <dbReference type="SMR" id="Q39RH2"/>
    <dbReference type="STRING" id="269799.Gmet_2934"/>
    <dbReference type="EnsemblBacteria" id="ABB33152">
        <property type="protein sequence ID" value="ABB33152"/>
        <property type="gene ID" value="Gmet_2934"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2934"/>
    <dbReference type="eggNOG" id="COG2022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062233_1_0_7"/>
    <dbReference type="OMA" id="PHNFQLI"/>
    <dbReference type="OrthoDB" id="784095at2"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990107">
        <property type="term" value="F:thiazole synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04728">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00443">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033983">
        <property type="entry name" value="Thiazole_synthase_ThiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008867">
        <property type="entry name" value="ThiG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34266">
        <property type="entry name" value="PTHR34266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05690">
        <property type="entry name" value="ThiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0704">Schiff base</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000236341" description="Thiazole synthase">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DXP" evidence="1">
        <location>
            <position position="102"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="189"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="211"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00443"/>
        </source>
    </evidence>
    <sequence length="260" mass="27648" checksum="F0A67B66475DBD2E" modified="2005-11-22" version="1">MSTTNDKLIIAGREFSSRLMVGTGKYASNEQMVAALEASGAEIITVAVRRVNITDRSKESLLDFIDTRKYTLLPNTAGCYTADDAVRTCRLAREAGMSDMVKLEVLGNETTLYPDNEELLKAAKILVKDGFTVLPYTSDDPIICKKLEDIGCAAVMPLGAPIGSGLGIRNPYTIRIIMETVKVPVIVDAGVGTASDAAIAMELGVDGVLMNTGIAGAQNPIAMAEAMNLAVRAGRLAYRAGRIPKKLYATASSPIEGMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RH4</accession>
    <name>Q39RH4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Menaquinol oxidoreductase complex Cbc5, membrane protein subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbcE</name>
        <name evidence="3" type="ordered locus">Gmet_2932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33150.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366126.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2932"/>
    <dbReference type="EnsemblBacteria" id="ABB33150">
        <property type="protein sequence ID" value="ABB33150"/>
        <property type="gene ID" value="Gmet_2932"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2932"/>
    <dbReference type="eggNOG" id="ENOG5033Z7A">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127579_0_0_7"/>
    <dbReference type="OMA" id="CHVGYLA"/>
    <dbReference type="OrthoDB" id="1700349at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33150.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="176" mass="19686" checksum="89736FF18A51444D" modified="2012-10-31" version="2">MKRFQPPPPKPDATGTPPDRDAVRQETVQRIKRLRSKSNRGLWAMALFIAVSIVALGDFSILPPLPPSIRATLGKPPSAIMISGALVLYTFSAIILILSRMMGGKEEYSGFAHVGYLAAFYGFYHFAKALNENFWAVFVAGVTILGLESYHIWNFCNEAIRREQEVLDSIERLRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S00</accession>
    <name>Q39S00_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2756</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366096.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2756"/>
    <dbReference type="EnsemblBacteria" id="ABB32974">
        <property type="protein sequence ID" value="ABB32974"/>
        <property type="gene ID" value="Gmet_2756"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2756"/>
    <dbReference type="HOGENOM" id="CLU_2422745_0_0_7"/>
    <dbReference type="OMA" id="VTEQDEF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="91" mass="10744" checksum="DF5CD9B2CCA87CDB" modified="2005-11-22" version="1">MGSSRQMGLRLDETDSMNLKRIAQREGRNEQDVLRDSLRMYVRHADEQKEFFDLVERGWYELRSGLGTVVSENDEFFDTLRRELRNGKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S91</accession>
    <name>Q39S91_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine protease inhibitor, Kunitz family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2665</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366080.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2665"/>
    <dbReference type="EnsemblBacteria" id="ABB32883">
        <property type="protein sequence ID" value="ABB32883"/>
        <property type="gene ID" value="Gmet_2665"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2665"/>
    <dbReference type="eggNOG" id="ENOG5033D86">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1692977_0_0_7"/>
    <dbReference type="OrthoDB" id="2024459at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004867">
        <property type="term" value="F:serine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00109">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002223">
        <property type="entry name" value="Kunitz_BPTI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036880">
        <property type="entry name" value="Kunitz_BPTI_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00014">
        <property type="entry name" value="Kunitz_BPTI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00131">
        <property type="entry name" value="KU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57362">
        <property type="entry name" value="SSF57362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50279">
        <property type="entry name" value="BPTI_KUNITZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="BPTI/Kunitz inhibitor" evidence="2">
        <location>
            <begin position="66"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="155" mass="17125" checksum="3AE38BE1C9E61378" modified="2005-11-22" version="1">MNRKIARIGKKAGLGEGEIRSFVRIGMSGLMALIISAFTGSAQADATVPLQDHVKPQAKEPLPEKCRLKPDGGPCKALFWKYYFDPKTNECKEFVYGGCEGVVPFETREECAQECLAQQAEPVIPDDDCGGPFPGYPCGTKYYTVSVRDFRHLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SB6</accession>
    <name>Q39SB6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2639</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511822.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2639"/>
    <dbReference type="EnsemblBacteria" id="ABB32858">
        <property type="protein sequence ID" value="ABB32858"/>
        <property type="gene ID" value="Gmet_2639"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2639"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="QMANSCD"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="186"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="396" mass="45236" checksum="1E6E71990CE8B8E9" modified="2005-11-22" version="1">MDGQFISMKPQILLVDDRPGNLSALEGLLDELDLVFVRALSGNEALRLTLKQDFALVLMDVQMPEMDGFETAELMRSNPKTRHLPIIFVTAGMKDLKFQFKGYDAGAVDYLAKPIEPAILRSKVRVFRDLYLQRMELELHRRNLQELVDQRTIQLRLAAQELEQRVIERTEELQQVNRQLESFAYSVSHDLRAPLRHIDAFSHILMDDYSQALDEEARNLLHRIVAGCDNMGKLIDAILALSRTVRQPLNKMPVSMERLARETFAQYREQYEGKEISFTVAELPESQADPVLLRQVYANLIGNALKYSSRREVPRIEVGAFPDNGETVYFVRDNGVGFDMRYADKLFAVFQRLHNGSEYEGTGVGLAIAQNIIQRHGGKIWAEAEPDKGATFFFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SD9</accession>
    <name>Q39SD9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonuclease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2616</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511845.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32835">
        <property type="protein sequence ID" value="ABB32835"/>
        <property type="gene ID" value="Gmet_2616"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2616"/>
    <dbReference type="eggNOG" id="COG4290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104572_3_1_7"/>
    <dbReference type="OMA" id="KSIGGDH"/>
    <dbReference type="OrthoDB" id="1964970at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001887">
        <property type="entry name" value="Barnase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="Gua-sp_ribonuclease_N1/T1/U2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00117">
        <property type="entry name" value="BARNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="SSF53933"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="176" mass="19670" checksum="9E5DB73E2B7DA4EC" modified="2005-11-22" version="1">MNTPHSVETKELPPPRRHHRKIPVLAILMIMALPAAGFGDRPAYADSCADVVHQVNRQLRPTIDEGELAAMLQSLNGSNNRNLPPKFVTKAQAKKMGWRPGRDLWASTRLKGKSIGGDRFANREGRLPAGGKKWHEADLDYQGGHRGAKRLIYSNDGLRMVTVDHYRTFTEVPPCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SK8</accession>
    <name>Q39SK8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2547</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513487.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32766">
        <property type="protein sequence ID" value="ABB32766"/>
        <property type="gene ID" value="Gmet_2547"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2547"/>
    <dbReference type="eggNOG" id="ENOG50338GU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989589_0_0_7"/>
    <dbReference type="OMA" id="GAKYPFY"/>
    <dbReference type="OrthoDB" id="1688043at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036709">
        <property type="entry name" value="Autotransporte_beta_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103515">
        <property type="entry name" value="SSF103515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223348" evidence="1">
        <location>
            <begin position="22"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="275" mass="30270" checksum="A8C532E37C676C3E" modified="2005-11-22" version="1">MINHIAITALAALLMVSPCLAAGLEEISAYGYGGYFSWQEYTNDGSRIVRESGPIFGAGAAARVDLLQRSLILHGKAELFGTVVDYAGQTQASSDPAENNRPADSDTRYFGGKIEGDLGWRFAFSGGSLEPFFGIGYRTWLRDIASSTATTETGRRFAVGSATEYWDTIYTRYGLKGELPIGNETAIFLEAGAKYPLYTRNRAEDTSAGDVTLEPRSDWSAFAELGVRHKAFRPAVFYEGFRFRRSPVEQRGIYQIHQPTSDSDIVGISLAYTFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SS1</accession>
    <name>Q39SS1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis sensory transducer, class 40+24H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mcp64H-2</name>
        <name evidence="7" type="ordered locus">Gmet_2478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366059.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2478"/>
    <dbReference type="EnsemblBacteria" id="ABB32703">
        <property type="protein sequence ID" value="ABB32703"/>
        <property type="gene ID" value="Gmet_2478"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2478"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_7"/>
    <dbReference type="OMA" id="VMESHAE"/>
    <dbReference type="OrthoDB" id="477199at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="227"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="368"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="698"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="733" mass="78274" checksum="2872A043EBF04164" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SV4</accession>
    <name>Q39SV4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferric uptake regulation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">fur</name>
        <name evidence="4" type="ordered locus">Gmet_2445</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512455.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2445"/>
    <dbReference type="EnsemblBacteria" id="ABB32670">
        <property type="protein sequence ID" value="ABB32670"/>
        <property type="gene ID" value="Gmet_2445"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2445"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_3_1_7"/>
    <dbReference type="OMA" id="YLYGVCT"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="143" mass="16538" checksum="5644E029465E5069" modified="2005-11-22" version="1">MKRVKQKIFQDYIARQGLKSTRQRDIILDAFLSSDRHLSIEELYLKLRAKHPNIGYATVYRTLKLFAESGIAREIHFGDGQTRYEHVSEGEHHDHLVCTGCGTIIEFENESIEKLQDEVAAAHNFLIKHHKLELYGLCAKCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SW2</accession>
    <name>Q39SW2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Winged-helix transcriptional response regulator KdpE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">kdpE</name>
        <name evidence="5" type="ordered locus">Gmet_2437</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512463.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2437"/>
    <dbReference type="EnsemblBacteria" id="ABB32662">
        <property type="protein sequence ID" value="ABB32662"/>
        <property type="gene ID" value="Gmet_2437"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2437"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_8_7"/>
    <dbReference type="OMA" id="KARKYEV"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="9"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="131"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="233" mass="26188" checksum="5DBAC1B2CF06AFD3" modified="2005-11-22" version="1">MPKENRLPRILIVDDELAIRRFLCTALDTGEFSLHQAENGHTALAAAVATMPDVILLDLGLPDMDGVEVIRRIREWSQVPIIVLSVREREDDKVAALDAGADDYLTKPFGVAELVARIRAALRRALQQVPEPIFRSGDLEVDLARRRVTVDGSESQLTPTEYELLRLLVVHAGKVLTHSQILRQIWGVSHLEQPHVLRVNISNLRRKIEMDPSRPRHILTEPGVGYRLRSDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SZ7</accession>
    <name>Q39SZ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512498.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2402"/>
    <dbReference type="EnsemblBacteria" id="ABB32627">
        <property type="protein sequence ID" value="ABB32627"/>
        <property type="gene ID" value="Gmet_2402"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2402"/>
    <dbReference type="eggNOG" id="COG4980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105320_5_0_7"/>
    <dbReference type="OMA" id="LDRGKDM"/>
    <dbReference type="OrthoDB" id="1904586at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="116" mass="12879" checksum="8CAFAB7711E5B16C" modified="2005-11-22" version="1">MSEDKNNTLMVGSLMLIAGGILGAGAALLFAPQSGKKTRRDIKKIARRARSEAEEMVEDFTDKVTDVVDNLNDKTQDILARGKEISQDVKKDLIKAFEEGKDRLEKEKSRLARMLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T08</accession>
    <name>Q39T08_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">4-alpha-glucanotransferase</fullName>
            <ecNumber evidence="3 7">2.4.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 7">Amylomaltase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 7">Disproportionating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">malQ</name>
        <name evidence="8" type="ordered locus">Gmet_2391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan to a new position in an acceptor, which may be glucose or a (1-&gt;4)-alpha-D-glucan.</text>
            <dbReference type="EC" id="2.4.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the disproportionating enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.25" evidence="3 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514767.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2391"/>
    <dbReference type="CAZy" id="GH77">
        <property type="family name" value="Glycoside Hydrolase Family 77"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32616">
        <property type="protein sequence ID" value="ABB32616"/>
        <property type="gene ID" value="Gmet_2391"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2391"/>
    <dbReference type="eggNOG" id="COG1640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014132_1_0_7"/>
    <dbReference type="OMA" id="TGQLWGT"/>
    <dbReference type="OrthoDB" id="814704at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102500">
        <property type="term" value="F:beta-maltose 4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003385">
        <property type="entry name" value="Glyco_hydro_77"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32438">
        <property type="entry name" value="PTHR32438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02446">
        <property type="entry name" value="Glyco_hydro_77"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00217">
        <property type="entry name" value="malQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="496" mass="55616" checksum="E4B1EB532E218A07" modified="2005-11-22" version="1">MHHRRKSGILLHPTSLPGPGGIGSLGKECRHFIDFLEAAGQSLWQILPLGPAAYGNSPYSCYSAFAGNPLLIDLAALVDEGDLDESAPVPVFPAEYVDFALAENYRIPLLKAAAAHFYAFGDRERKEEYWHFCDTTPWLHDYALFMALKEHFGGKSWTSWPKEIARREPAALEKYSVRLGVAIGEQKYAQWQFYRQWRHIREYANGKGIGIVGDIPIFVAFDSADVWSAPHLFKLDEKGKPTVVAGVPPDYFSETGQRWGNPLYNWDAMAAEGYRWWIERFRSCFALCDMVRIDHFRGFEACWEVPAKEKTAVNGQWVKGPGAPLFDAVIGALGQLPIIAEDLGVITPEVEELRDRYRFPGMKILQFAFDSGPGNPYLPHNYIPGCVTYTGTHDNDTTVGWFKTLSPHNRKGVLAYTGTSGKEIHWELVRLGLASVADLAIFPLQDILGLDGSARMNLPGTPRGNWSWRFTAGALAEKHAERLHELTTLFGRKRGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T45</accession>
    <name>FABZ_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ</fullName>
            <ecNumber evidence="1">4.2.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase</fullName>
            <shortName evidence="1">(3R)-hydroxymyristoyl-ACP dehydrase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-hydroxyacyl-ACP dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabZ</name>
        <name type="ordered locus">Gmet_2354</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioester dehydratase family. FabZ subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.59" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513266.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T45"/>
    <dbReference type="SMR" id="Q39T45"/>
    <dbReference type="STRING" id="269799.Gmet_2354"/>
    <dbReference type="EnsemblBacteria" id="ABB32579">
        <property type="protein sequence ID" value="ABB32579"/>
        <property type="gene ID" value="Gmet_2354"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2354"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_3_0_7"/>
    <dbReference type="OMA" id="FPGRPLM"/>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008659">
        <property type="term" value="F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008693">
        <property type="term" value="F:3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047451">
        <property type="term" value="F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004317">
        <property type="term" value="F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00406">
        <property type="entry name" value="FabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010084">
        <property type="entry name" value="FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01750">
        <property type="entry name" value="fabZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000230814" description="3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00406"/>
        </source>
    </evidence>
    <sequence length="150" mass="16769" checksum="8E1DEC6F8BF3ADA4" modified="2005-11-22" version="1">METVFDINEIMKILPHRYPFLLVDRIVEHVPGERIVGIKNVTINEPFFQGHFPGHPIMPGVLIVEAMAQVGGILAYMASDDEVRNKVCYFASIDNVKFRKPVLPGDQLRIEVAATGCKRGIWCFSAKAIVKGKVTTQAELKATFADKDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T74</accession>
    <name>Q39T74_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GTP/GDP 3'-pyrophosphokinase and (P)ppGpp 3'-pyrophosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">relA</name>
        <name evidence="5" type="ordered locus">Gmet_2325</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the relA/spoT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513295.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2325"/>
    <dbReference type="DNASU" id="3739486"/>
    <dbReference type="EnsemblBacteria" id="ABB32550">
        <property type="protein sequence ID" value="ABB32550"/>
        <property type="gene ID" value="Gmet_2325"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2325"/>
    <dbReference type="eggNOG" id="COG0317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012300_3_0_7"/>
    <dbReference type="OMA" id="YKTIHTT"/>
    <dbReference type="OrthoDB" id="204079at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01668">
        <property type="entry name" value="TGS_RSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004811">
        <property type="entry name" value="RelA/Spo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045600">
        <property type="entry name" value="RelA/SpoT_AH_RIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033655">
        <property type="entry name" value="TGS_RelA/SpoT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13291">
        <property type="entry name" value="ACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19296">
        <property type="entry name" value="DUF5913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00691">
        <property type="entry name" value="spoT_relA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="3">
        <location>
            <begin position="45"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="385"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="2">
        <location>
            <begin position="642"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="716" mass="81333" checksum="61D092DE02458D23" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TG1</accession>
    <name>Q39TG1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365991.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2236"/>
    <dbReference type="EnsemblBacteria" id="ABB32463">
        <property type="protein sequence ID" value="ABB32463"/>
        <property type="gene ID" value="Gmet_2236"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2236"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="DGPLDHY"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="266" mass="27769" checksum="098DEE74B6AB78F2" modified="2005-11-22" version="1">MLKIEDKPVSGLLDLSGKRAVVTGAAAGIGYAIAKRLAEAGATVLITDINREAIEEAEHRLSSMKCKVKSLVSDAGREADIKSLFSYVADSFGGVDILVNNAGIYPATKILDMSLEQWREVIRINLESAFLCSQEAGRIMVRQGTGGVIVNISSMAALKPCFPGLAHYGASKGGVVNLTRSTALELAPHKIRAVAVVPGGILTGGVRSNLKQSEEKDSLQSIGATIPLGGFGQPDDIARTVLFLASDSAAYITGTTILVDGGAMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TM1</accession>
    <name>Q39TM1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365932.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2174"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32403">
        <property type="protein sequence ID" value="ABB32403"/>
        <property type="gene ID" value="Gmet_2174"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2174"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_2_1_7"/>
    <dbReference type="OMA" id="IKYRQHG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="308" mass="35524" checksum="BC845B080FAE3C3C" modified="2005-11-22" version="1">MKPRVEILMSTYNGEKFLAEQLDSILAQTHQYFVLTVRDDGSKDGTPDILSRYAATDERITYCVQENRGVVGSFYWLLKNSSPLSNYVAFSDQDDVWLPNKLERALDVLSRYDETLPLLYCSRVEYVSAGLGHLDDSPMMVRPVCLNNALIQNVATGCTVVMNKAARDLLLEREWPPQVLMHDWWSYIVVSAFGKVVYDDFVSIKYRQHGGNVIGGTVSFVSDYRSRIINFLSRRRKGVFGCYDQAYSFWLGYKDELKGESRGIVSQFIESKRSFLSRLNYLTSSQRVYRHRFIDDVLVRLLILSNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TQ7</accession>
    <name>Q39TQ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-hydroxybenzoyl-CoA reductase molybdenum cofactor biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pcmV</name>
        <name evidence="1" type="ordered locus">Gmet_2138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513067.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2138"/>
    <dbReference type="EnsemblBacteria" id="ABB32367">
        <property type="protein sequence ID" value="ABB32367"/>
        <property type="gene ID" value="Gmet_2138"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2138"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082089_1_0_7"/>
    <dbReference type="OMA" id="ETNRGHN"/>
    <dbReference type="OrthoDB" id="1072730at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017695">
        <property type="entry name" value="Se-dep_Mo_hydrolase_YqeB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03309">
        <property type="entry name" value="matur_yqeB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="268" mass="28396" checksum="74C1F0CA73C027F0" modified="2005-11-22" version="1">MKRLTERVIIMKGAGEMATGVACRLHRSGFRRILMLEAPSPLAVRRGVSFCEAIHNGRKSVEGIEAVRIENGSALADAWGKGEIPLLADPQGDAVRRMEPDILIDATIAKRNLGIAITDAPLVIALGPGFFAGRDCHLVIETNRGHNLGRLIACGEAEPNTGIPGNIGGYTRERVLRAPADGHFTTEKVIGDQVSKGDVVGIVGTNTVTASIDGILRGLIRPGTHVTTGLKIGDIDPRGDTAYCHTISEKARALGGSVLEAILTVYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TS8</accession>
    <name>Q39TS8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513088.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2117"/>
    <dbReference type="EnsemblBacteria" id="ABB32346">
        <property type="protein sequence ID" value="ABB32346"/>
        <property type="gene ID" value="Gmet_2117"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2117"/>
    <dbReference type="HOGENOM" id="CLU_725142_0_0_7"/>
    <dbReference type="OMA" id="WIIVWIQ"/>
    <dbReference type="OrthoDB" id="1770098at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="381" mass="42016" checksum="0467DDFB7EC3D251" modified="2005-11-22" version="1">MTAMNDGQHGATMDELVNNGLDNVNSGTRAAVPGIAQLGFYLVIFMAISWAMMFFIPTPFLFTVLLPASFYVLYSLVVFSPLVSGGWPFAPPLGSWRPGQSWLKPGVGTTALLVAVAIAGPLFTSTIYPRIPLFPVGFWWGIILFTVTLWYSMVWNGWPLNGKCSPAVRGIGGGLIILLITALLWQLVNLGGTPFADAPYDPRGPFQAEWFFGLLVWIIVWIQAFANVLTFQQWPFYKLGEPWGQIANTVVSIVLGWLCWTTSLKFMAPTFSFAAVAGSIIGMQNFHGAIFGYYPFLKFKQPKRGICNFLTEIALAFVWIALLRVLMQPIVAKVQAAGLPFDINVVSVLYTLHFIALLTLIHNFYFLRAPLPPSGPPPAPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TT8</accession>
    <name>Q39TT8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenol transport outer membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365919.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2107"/>
    <dbReference type="EnsemblBacteria" id="ABB32336">
        <property type="protein sequence ID" value="ABB32336"/>
        <property type="gene ID" value="Gmet_2107"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2107"/>
    <dbReference type="eggNOG" id="COG4313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066206_2_0_7"/>
    <dbReference type="OMA" id="HEYGARN"/>
    <dbReference type="OrthoDB" id="1322015at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025737">
        <property type="entry name" value="Phenol_MetA_deg_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13557">
        <property type="entry name" value="Phenol_MetA_deg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223120" evidence="1">
        <location>
            <begin position="30"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="309" mass="34231" checksum="683EAA09574A6C80" modified="2005-11-22" version="1">MKQFSLRRLLFLPCIALAVFLFSAPLTWAGGGQHYPNGVEDFAVGALPPPGVYLVNYLLLVQKNSIKDNSGNSVPADFKADVVAEVPRLIYVSPFKLLGANWGAHVFLPFYHADVKSSSDIPPLNFDSRDTGMGDLIFSPLILGWHFTPSLHAVFALDTWAPTGDYDKNRPATQILSRNHWTFEPVVAVSYLKEGFDVSAKLMYDFNTRNSDTGTDPGQEFHIDWAAGYGLSNGLSGGVVGYNYWQTTDDKVNGVRVEDANSRVGGIGFGIKYWPKQGPFSMTFKQYWEYGARNIATGPQTQFKISYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TZ2</accession>
    <name>Q39TZ2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">DNA mismatch repair protein MutL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">mutL</name>
        <name evidence="9" type="ordered locus">Gmet_2053</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32282.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365912.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2053"/>
    <dbReference type="EnsemblBacteria" id="ABB32282">
        <property type="protein sequence ID" value="ABB32282"/>
        <property type="gene ID" value="Gmet_2053"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2053"/>
    <dbReference type="eggNOG" id="COG0323">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004131_4_2_7"/>
    <dbReference type="OMA" id="AHERIMY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00149">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020667">
        <property type="entry name" value="DNA_mismatch_repair_MutL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="DNA_mismatch_repair_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="PTHR10073"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="SSF118116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA_mis_repair" evidence="8">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="MutL_C" evidence="7">
        <location>
            <begin position="409"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32282.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="594" mass="65723" checksum="BB8ADFE1694B962E" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U34</accession>
    <name>Q39U34_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase, type 12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2011</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32240.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512939.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2011"/>
    <dbReference type="EnsemblBacteria" id="ABB32240">
        <property type="protein sequence ID" value="ABB32240"/>
        <property type="gene ID" value="Gmet_2011"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2011"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088541_0_0_7"/>
    <dbReference type="OMA" id="QTHLRFF"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32240.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="220" mass="25313" checksum="4F14995DBA063072" modified="2012-10-31" version="2">MENLLGSNHKPANYYNSSRLEMLRFMPDNVNKILDVGCGAGEFGHALKSQRPVEVWGVELSHEAAKEAQTKLDKVIVGSIEAGPLSLPELYFDCIVFNDVLEHLVDPWAILVGIKAFMQPDCRVVASIPNVRYYDNIKQLIKYKQWKYNDEGILDKTHLRFFTNESIKDLFDMCGYKIISMKGIGETQFPWKFRMINQLLGNTFDDMKYRQFACVGMQKD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U59</accession>
    <name>COAX_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Type III pantothenate kinase</fullName>
            <ecNumber evidence="1">2.7.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PanK-III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantothenic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">coaX</name>
        <name type="ordered locus">Gmet_1986</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16373"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NH4(+)</name>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
        </cofactor>
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">A monovalent cation. Ammonium or potassium.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type III pantothenate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.33" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512965.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39U59"/>
    <dbReference type="SMR" id="Q39U59"/>
    <dbReference type="STRING" id="269799.Gmet_1986"/>
    <dbReference type="EnsemblBacteria" id="ABB32215">
        <property type="protein sequence ID" value="ABB32215"/>
        <property type="gene ID" value="Gmet_1986"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1986"/>
    <dbReference type="eggNOG" id="COG1521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066627_1_0_7"/>
    <dbReference type="OMA" id="HEPWLTL"/>
    <dbReference type="OrthoDB" id="2039419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00352"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01274">
        <property type="entry name" value="Pantothen_kinase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004619">
        <property type="entry name" value="Type_III_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34265">
        <property type="entry name" value="PTHR34265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03309">
        <property type="entry name" value="Pan_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00671">
        <property type="entry name" value="baf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000267540" description="Type III pantothenate kinase">
        <location>
            <begin position="1"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="6"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01274"/>
        </source>
    </evidence>
    <sequence length="255" mass="28028" checksum="601435AE6281C463" modified="2005-11-22" version="1">MLLVIDVGNTNIVLGIYDGQRLVRDWRISTDKAKTSDEYGILIRELFRGADIEFKDVKAIIISSVVPTLSGVLERLSRNYFGYSPLVVGPGIRTGMPIQYDNPKEVGADRIVNAVAGYEKYKTSLVIVDFGTATTFDYVNRKGEYCGGAIAPGLVISMEALFQRASKLPRVDIVKPPAVIARNTVNSMQAGIFYGYVGLVDEIVARMKAESKETPRVIATGGLAGLIAPESKTIEAVEEYLTLEGLRILYERNRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U62</accession>
    <name>Q39U62_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1983</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512968.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1983"/>
    <dbReference type="EnsemblBacteria" id="ABB32212">
        <property type="protein sequence ID" value="ABB32212"/>
        <property type="gene ID" value="Gmet_1983"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1983"/>
    <dbReference type="eggNOG" id="ENOG5032SIJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061334_0_0_7"/>
    <dbReference type="OMA" id="NDEIMRV"/>
    <dbReference type="OrthoDB" id="571821at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="267" mass="29596" checksum="7B990F0B72D32256" modified="2005-11-22" version="1">MIGGEVELSSPDLTTVLFVLAHDPDGEVSGGARKCLAELPEGVLREAVSAPALHPRILDGLARLYLRNREIASLIVSHPHCPEETRLFLAEQGIEVPHRTVSTSHSTAEEAAQEFPDNGEEEVDEESEAFRGKYQLAQVMGVSDKIKIAQTGDKEWRMILIRDSNKLVSGTVIKNPRITEQEVLTICKSSIQNDEILRVICANKEWIKNYQIRKALVENNKTSLPSALRFLATLNEKDLAHLAKSKGISSVLSTQARKLLLSKKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U76</accession>
    <name>Q39U76_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511875.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1969"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32198">
        <property type="protein sequence ID" value="ABB32198"/>
        <property type="gene ID" value="Gmet_1969"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1969"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_32_1_7"/>
    <dbReference type="OMA" id="VSSWVNQ"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022622">
        <property type="entry name" value="DUF3492"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11997">
        <property type="entry name" value="DUF3492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3492" evidence="2">
        <location>
            <begin position="11"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="310"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="503" mass="56818" checksum="EDD4864FFEBCF287" modified="2005-11-22" version="1">MDRFPKSDNVDIMLLLEGTFPYVSGGVSSWVNQIILAFPEYRFGALFIGSSRSDYGEFKYDLPPNLVHLECHYLHDELAMPAIRPMAGNSGAFETVRRIHELFLRPDEGTLDRALKTPDFYLDSNNGANFEQFLYSKKSWELICDLYQERCTDPSFVDYFWTVRNMHTPIWLLAAIAKRLIPARVYHTVSTGYAGFLGALLHHNSGRPLILSEHGIYTKERRIDIFSSDWIQDNRNALQKDPTEVSYYRDLWIRFFETIGRFCYGAASNIVSLYEGAREREIGDGAPRERTMVVPNGINIARFAKLRERRPDNPPPVLTLVGRVVPIKDIKTFIRALRLAANSLPGVQGWIIGPEDENPEYAAECRDLAESLHIASNLSFMGFRNPMEIFPDTGVMILSSVSEGVPLVILEAFAAGIPVVATDVGACRQLIMGHGQEDEAIGAAGGVVSINNPHDLAGEALRLLKDPDHWKRASNAAISRVERYYTEQQMFDSYRQLYQRGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UF4</accession>
    <name>Q39UF4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthase</fullName>
            <ecNumber evidence="7">6.3.4.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-2-lysyl-cytidine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">tRNA(Ile)-lysidine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">tilS</name>
        <name evidence="9" type="ordered locus">Gmet_1891</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + cytidine(34) in tRNA(Ile2) + L-lysine = AMP + diphosphate + H(+) + lysidine(34) in tRNA(Ile2)</text>
            <dbReference type="Rhea" id="RHEA:43744"/>
            <dbReference type="Rhea" id="RHEA-COMP:10625"/>
            <dbReference type="Rhea" id="RHEA-COMP:10670"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:83665"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.19"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the tRNA(Ile)-lysidine synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.19" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511953.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1891"/>
    <dbReference type="EnsemblBacteria" id="ABB32120">
        <property type="protein sequence ID" value="ABB32120"/>
        <property type="gene ID" value="Gmet_1891"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1891"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018869_0_1_7"/>
    <dbReference type="OMA" id="QQYGMNA"/>
    <dbReference type="OrthoDB" id="666797at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01992">
        <property type="entry name" value="PP-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01161">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012796">
        <property type="entry name" value="Lysidine-tRNA-synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012094">
        <property type="entry name" value="tRNA_Ile_lys_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012795">
        <property type="entry name" value="tRNA_Ile_lys_synt_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43033">
        <property type="entry name" value="PTHR43033"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11734">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00977">
        <property type="entry name" value="TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02433">
        <property type="entry name" value="lysidine_TilS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02432">
        <property type="entry name" value="lysidine_TilS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TilS_C" evidence="8">
        <location>
            <begin position="385"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="468" mass="51336" checksum="BE34897AA7EA7B5F" modified="2005-11-22" version="1">MRSVHAKVLAFSTEHSLFTPGDTVVVAVSGGADSVALLDILISLSDLRLNLVVAHLNHSLRGAESDGDERFVADLAASRGLPFAGEKADVRALSIRERLSLEDAGRRARYEFFDRVATQYGARSVALAHHADDQAETLLLRLLRGAGVTGLSAMAPRRDGRFVRPLLTLSRSEIEGYLHGRGLRFRIDSSNADTAFLRNRIRHELIPHLVRFNPEISRRLAVTADLLAVDEEVLETVADEALKRTAREHSGEGVILDVAGLLREPRGVRYRIYRRAVALAMGTLRGLSYKHVLQIDGLVRSPKPNLHIPVPGGVGVVRAYGLVTFKAAGVAGIEWEDELIIEGPGCYPLPDGGEMVIDVVSPPADLVTLPSERACFDLDCAPFPWVVRGFRPGDRINPLGMTGTKKVKDIFIDEKVPRERRRLVPLVFSNSELVWVCGYRTGHHARVTEKTVCTVLAEVRTSTGIALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UM3</accession>
    <name>Q39UM3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Branched-chain amino acid ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">livH</name>
        <name evidence="7" type="ordered locus">Gmet_1822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512023.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1822"/>
    <dbReference type="EnsemblBacteria" id="ABB32051">
        <property type="protein sequence ID" value="ABB32051"/>
        <property type="gene ID" value="Gmet_1822"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1822"/>
    <dbReference type="eggNOG" id="COG0559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039929_1_1_7"/>
    <dbReference type="OMA" id="PILIWRS"/>
    <dbReference type="OrthoDB" id="1529037at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001851">
        <property type="entry name" value="ABC_transp_permease"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02653">
        <property type="entry name" value="BPD_transp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="294" mass="30914" checksum="4DFFC51FB4639321" modified="2005-11-22" version="1">MHIGQQIAQYLLSGLSTGAIYALIGVGFAIIHNATGIINFAQGEFVMLGGMFTVFFLTVLNLPLLVSVILAIAASTIAGVAFERLAIRPMKNASPISLVIITVGGSILIRGIAMLVWGKDTHALETFSGNEPIQLGEATILPQHLWIFAVTTVVIICSKLYFNYTISGKAMRACAYNSRAAGLVGIDVRRMVLFSFAISSAMGSMAGIIIAPLTMTSYDVGVMLGLKGFCAAIIGGMSSGLGTVFGGVILGILESLGAGIFSSGYKDAIAFIILLIILFIRPHGLFSKGDTERV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39US3</accession>
    <name>PYRC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroorotase</fullName>
            <shortName evidence="1">DHOase</shortName>
            <ecNumber evidence="1">3.5.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrC</name>
        <name type="ordered locus">Gmet_1770</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-dihydroorotate + H2O = H(+) + N-carbamoyl-L-aspartate</text>
            <dbReference type="Rhea" id="RHEA:24296"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="EC" id="3.5.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="ABB32001" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EC" id="3.5.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32001.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513333.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39US3"/>
    <dbReference type="SMR" id="Q39US3"/>
    <dbReference type="STRING" id="269799.Gmet_1770"/>
    <dbReference type="EnsemblBacteria" id="ABB32001">
        <property type="protein sequence ID" value="ABB32001"/>
        <property type="gene ID" value="Gmet_1770"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1770"/>
    <dbReference type="eggNOG" id="COG0044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015572_1_0_7"/>
    <dbReference type="OrthoDB" id="1319925at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00117"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004151">
        <property type="term" value="F:dihydroorotase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01317">
        <property type="entry name" value="DHOase_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00220_B">
        <property type="entry name" value="PyrC_classI_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004722">
        <property type="entry name" value="DHOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00483">
        <property type="entry name" value="DIHYDROOROTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000325594" description="Dihydroorotase">
        <location>
            <begin position="1"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="424" mass="44713" checksum="0DC8AA0CE041462B" modified="2008-03-18" version="2">MNLLIQGGRVIDPSQGIDEVLDILVENGAVKELGKGVKAPSGTETIDASGLIVTPGLIDMHVHLRDPGHEYKEDIVSGTKAAAAGGFTSVACMPNTKPVNDNKAVTSYIIAKAKAEGSVNVFPVGSITQGSKGELLSEMGELKESGCVAVSDDGHPVTNSELMRRALEYAKGMGIMVISHAEDLSLVGAGVMNEGFVSTELGLKGIPWAAEDAATARDVYLAEFTDSPLHIAHVSTKGSLRIIRNAKARGVKVTCETAPHYFSLTDDAVRGYDTNAKMNPPLRTADDVTAVKEALKDGTIDAIATDHAPHHIDEKDLEFNEALNGIVGLETSLTLSLRLVEEGVLTLPVLVDKMACNPAKILGIDRGTLKPGSVADITVIDPKATWTVDADKLASKSKNSPFLGWEVKGAAAFTIVGGKVVYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UV4</accession>
    <name>Q39UV4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acetoin utilization protein AcuC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Ketone degradation; acetoin degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the histone deacetylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513366.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1739"/>
    <dbReference type="EnsemblBacteria" id="ABB31970">
        <property type="protein sequence ID" value="ABB31970"/>
        <property type="gene ID" value="Gmet_1739"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1739"/>
    <dbReference type="eggNOG" id="COG0123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007727_8_0_7"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="OrthoDB" id="1443295at2"/>
    <dbReference type="UniPathway" id="UPA00040"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045150">
        <property type="term" value="P:acetoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016575">
        <property type="term" value="P:histone deacetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09994">
        <property type="entry name" value="HDAC_AcuC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003085">
        <property type="entry name" value="AcuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="His_deacetylse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="His_deacetylse_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01272">
        <property type="entry name" value="ACUCPROTEIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="SSF52768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0006">Acetoin catabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hist_deacetyl" evidence="5">
        <location>
            <begin position="24"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="385" mass="42614" checksum="1E4569A4E3B29E8B" modified="2005-11-22" version="1">MPAKTALIYSNDFSRFSYGDDHPFKIQRIILARELMGMLGLTELPGACIHDCPRADEASLLTFHSPDYLQRLREFSDSDEPRADFRYGLGDLDNPVFKGFYDWAILGVGGTMEAARLVTEEGYDIAFTMAGGWHHAHRSKASGFSYLNDAVIAINTLVAKGLRVAYLDIDAHHGDGVQEAFYDTDQVLTVSIHESGIYFFPGTGFEDEIGRGQGRGYSVNVPLVAHTDDALFMKAFDEVAYPLIAAYNPDVLVTQLGVDTFRTDPLTRLEITTHSYTYILRKLKALKIPWVAVGGGGYNMINVARGWTLAWGIMNGVELPPKLPAQFVDMIAPMGHPNRMLLDAMHWAEEDDRNRALDAVERSIAAIRETVFPVIIGNYAAAAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UY4</accession>
    <name>Q39UY4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA--carboxylate coenzyme A transferase, alpha subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1709</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514145.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1709"/>
    <dbReference type="EnsemblBacteria" id="ABB31940">
        <property type="protein sequence ID" value="ABB31940"/>
        <property type="gene ID" value="Gmet_1709"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1709"/>
    <dbReference type="eggNOG" id="COG1788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049557_0_0_7"/>
    <dbReference type="OMA" id="SHYGMVC"/>
    <dbReference type="OrthoDB" id="1660857at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="321" mass="35888" checksum="87FAFE071D5E3FA7" modified="2005-11-22" version="1">MGTGKRITLQQAAEIIKDGSSLTFSGFTIWRRPMAIVFELIRQQRRGLHLIEVNGGPHTEFLVGAGCVDIWESCWVGHELYGKYGANLSRKVGNKEIIVEDYSHAEMMFRFAAGAAGAPYAVTQTSLGTDIHNPEYDMLGRAGKRDGKRIPKHKYLFTDDPFYGAGPQVLVPAAKADIAIMCVQQVGEEGTVRVNGQYYSDPEAARTADITIVMAEEIVPEEYLRREADRNTITSFEVDYIVECPYGAHPTGMFGRYDVDGAFLKDFYGRTRTQEGFDDFAKEWIMGLDHLGYLEKLGWPRMLTLKANTALNYSTGVKRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V30</accession>
    <name>Q39V30_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, AraJ family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1663</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1663"/>
    <dbReference type="EnsemblBacteria" id="ABB31894">
        <property type="protein sequence ID" value="ABB31894"/>
        <property type="gene ID" value="Gmet_1663"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1663"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_690654_0_0_7"/>
    <dbReference type="OMA" id="AGYWMTP"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="12"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="385" mass="39847" checksum="0C2351A652BFA990" modified="2005-11-22" version="1">MTETAPPRMDLRLAALLIGVILSTVDSSALNLALPTLAAHFGTDASAVQGAISLYLVGSALAFLPLSSIAGRVGTVRVYRVSLAAFAVISQFLAFSPNLQTLLVLRFLQGIAGAGIVGLVPGMTAATFREHRGWALGMVSGSVAAGTLIGPPLGGFLVEWLGWRSIFYINLPFGLLALLLSSRLTELMGVGLVEGLRRIIRAPRFILALTSTVCFFIHSFGTNLIWPFYLEAGGMSPAKVGLFMLVPPVMLMVAGPSCGKMSDSRGYDRVSWLGSAVLMAASLGQGLSGSVIIGLMGIGIGRALFQAANNAAVLSQAPEGTNTVASGLLSIARVSGQALGSVLAGILWGKLEHGGTSRAFLVVNLVMAAVAALAGCLIIGRSRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V33</accession>
    <name>Q39V33_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2384 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511403.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1660"/>
    <dbReference type="EnsemblBacteria" id="ABB31891">
        <property type="protein sequence ID" value="ABB31891"/>
        <property type="gene ID" value="Gmet_1660"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1660"/>
    <dbReference type="eggNOG" id="COG5642">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123925_2_0_7"/>
    <dbReference type="OMA" id="IGRIDRD"/>
    <dbReference type="OrthoDB" id="1850771at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024467">
        <property type="entry name" value="Xre/MbcA/ParS-like_toxin-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09722">
        <property type="entry name" value="DUF2384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2384" evidence="1">
        <location>
            <begin position="92"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="135" mass="15344" checksum="5912600D5150BE83" modified="2005-11-22" version="1">MLLTQIRPSEIDLHSTEARGALAKMIIKLFTHWGLSTADQLELLGLSPKSRGLLAKYAKGEALPEGRDSLDRVGYLLSIHKSLRLLYPYNPEIRYSWVNRRNTAFNNLTPLAVMKEQGIIGLARVARYLDYYRGL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VA5</accession>
    <name>RBFA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-binding factor A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rbfA</name>
        <name type="ordered locus">Gmet_1587</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RbfA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511478.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VA5"/>
    <dbReference type="SMR" id="Q39VA5"/>
    <dbReference type="STRING" id="269799.Gmet_1587"/>
    <dbReference type="EnsemblBacteria" id="ABB31819">
        <property type="protein sequence ID" value="ABB31819"/>
        <property type="gene ID" value="Gmet_1587"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1587"/>
    <dbReference type="eggNOG" id="COG0858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089475_6_3_7"/>
    <dbReference type="OMA" id="GDLQHCK"/>
    <dbReference type="OrthoDB" id="1971380at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00003">
        <property type="entry name" value="RbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000238">
        <property type="entry name" value="RbfA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023799">
        <property type="entry name" value="RbfA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020053">
        <property type="entry name" value="Ribosome-bd_factorA_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33515">
        <property type="entry name" value="PTHR33515"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02033">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89919">
        <property type="entry name" value="SSF89919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00082">
        <property type="entry name" value="rbfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01319">
        <property type="entry name" value="RBFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_1000000113" description="Ribosome-binding factor A">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00003"/>
        </source>
    </evidence>
    <sequence length="118" mass="13233" checksum="C8319B4023049471" modified="2005-11-22" version="1">MYKRSDKVAEAIHELVSGLLVKGLKDPRIGFVTITGVKVSDDIRHATIYYTVMGSDEAKKSTLHGLNSSVGFIRKEVSKELRLRFAPELIFKYDESIEYGNRIDQLLKEIGSEEGGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VE1</accession>
    <name>Q39VE1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal ion efflux pump, RND family, outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511517.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1549"/>
    <dbReference type="EnsemblBacteria" id="ABB31783">
        <property type="protein sequence ID" value="ABB31783"/>
        <property type="gene ID" value="Gmet_1549"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1549"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_15_0_7"/>
    <dbReference type="OMA" id="ISARENY"/>
    <dbReference type="OrthoDB" id="1533572at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223169" evidence="2">
        <location>
            <begin position="24"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="426" mass="48915" checksum="21610A328B2A5710" modified="2005-11-22" version="1">MKSRLAIGFMLLAVLALPYQAPAEETKPSENLPQLVDAALANNPEVKASEARWEMFRNRVAQAGALDDPMLMLKMQSFLIRDPFNSRRDPMSQRVIGISQQLPFWGKRDLKAEVASREAEALKWQVAERKLELARMVKETWYQIFLTDKELQIVEKNIRIMDDFIALAETKYSVGQGAQQDVFKAQVERSKMVDMKISLEQQRKSLQATLNTLLYRPAETPVGKVADFELKPFTWSPDQLRSMAQENRPLVKSLRAEIEKGEAGHRLAEKEYFPDVNLSFEYMQRDPINDMEAGYDMYSAGLTFNLPIQRERRHAMVRESSAEIAMATAELNTLNNSINLGIADSLAQLERREKLAKLYRTGIIPQAEQSLESATIGYRVNKVDFLTLLDNRLTLFNYERDYYESLAEYQMRLAQLEALVGKELQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VJ7</accession>
    <name>Q39VJ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, WfgS-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511574.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1493"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="DNASU" id="3740210"/>
    <dbReference type="EnsemblBacteria" id="ABB31727">
        <property type="protein sequence ID" value="ABB31727"/>
        <property type="gene ID" value="Gmet_1493"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1493"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_21_0_7"/>
    <dbReference type="OMA" id="WEAFRIA"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="14"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="286" mass="32969" checksum="8F2380022815A304" modified="2005-11-22" version="1">MSSQLNHGTLPKISIVTPSYNQAQYLEATMRSILDQGYPDLEYIVMDGGSTDGSTEIIQKYSDRLTYWESAPDKGQADAIFRGFERATGEIFCYVNSDDLLLPGSLEMVGRWFREHPDEEWVVGGTILIDGLGIPIIRSRRGLPEADLGVKVTFKRLLLHNCGGFHQPASFWRRSAFEQAGGFDRTLRFCFDYDLFFRLAKRRPSGRIRSFLAAFRYHPASKTSTLESVFREENETLWRRYGRYLYSENQIRNFAHKQTTRDMWNNRIIKLGFYLKILNVSNAIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VL1</accession>
    <name>Q39VL1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1479"/>
    <dbReference type="EnsemblBacteria" id="ABB31713">
        <property type="protein sequence ID" value="ABB31713"/>
        <property type="gene ID" value="Gmet_1479"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1479"/>
    <dbReference type="eggNOG" id="ENOG502Z8IY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_382554_0_0_7"/>
    <dbReference type="OMA" id="WPESSYW"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="723" mass="82910" checksum="80120EF7565A80F5" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VN6</accession>
    <name>Q39VN6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511616.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31688">
        <property type="protein sequence ID" value="ABB31688"/>
        <property type="gene ID" value="Gmet_1454"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1454"/>
    <dbReference type="HOGENOM" id="CLU_2584743_0_0_7"/>
    <dbReference type="OrthoDB" id="2101598at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="80" mass="9182" checksum="24385EC288AFE61C" modified="2005-11-22" version="1">MAKAKTERHCKGRAETTLNVERQNGKILRLSRSEKYQRLVDMLNDLSSNEFTGYIKVNFSQGGIGRIEKFEEISFNRAGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VW3</accession>
    <name>Q39VW3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lytic transglycosylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1377</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513131.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1377"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31611">
        <property type="protein sequence ID" value="ABB31611"/>
        <property type="gene ID" value="Gmet_1377"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1377"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013746_1_0_7"/>
    <dbReference type="OMA" id="RKERQHT"/>
    <dbReference type="OrthoDB" id="859969at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008939">
        <property type="entry name" value="Lytic_TGlycosylase_superhlx_U"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48435">
        <property type="entry name" value="SSF48435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223441" evidence="3">
        <location>
            <begin position="22"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="4">
        <location>
            <begin position="557"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="719" mass="80083" checksum="5D64F9531D49B232" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VY2</accession>
    <name>Q39VY2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1358</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365819.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1358"/>
    <dbReference type="CAZy" id="CBM50">
        <property type="family name" value="Carbohydrate-Binding Module Family 50"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31592">
        <property type="protein sequence ID" value="ABB31592"/>
        <property type="gene ID" value="Gmet_1358"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1358"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1208366_0_0_7"/>
    <dbReference type="OMA" id="RDPRHIW"/>
    <dbReference type="OrthoDB" id="1800203at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025511">
        <property type="entry name" value="DUF4398"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14346">
        <property type="entry name" value="DUF4398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223346" evidence="2">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="157"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="230" mass="26708" checksum="6AB891552593C29B" modified="2005-11-22" version="1">MKTRNLAMVSVLALCLAGCAQGLPRYRTEALTKFSSVRMQGGERARAEEFTSITDALEAGDRLLERNRVSDAEQFYLLALRKSELAEQQLAAENVRHEAQRLKAEEDRRAAERQRILEEQKRRMIEEREREARETRKKVDKPVAVKEKEREVRHLPSVHTVKRGETLPQIAAQSEVYGDALLWPLIYRANRDQIRDPKRIWPGQVLRIPRNAGRDDIAEAHRIAQERRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W10</accession>
    <name>Q39W10_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1329</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1329"/>
    <dbReference type="EnsemblBacteria" id="ABB31564">
        <property type="protein sequence ID" value="ABB31564"/>
        <property type="gene ID" value="Gmet_1329"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1329"/>
    <dbReference type="eggNOG" id="COG1442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054561_1_0_7"/>
    <dbReference type="OMA" id="VIYFDPD"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="450" mass="51995" checksum="C18CEBAAFA6AA282" modified="2005-11-22" version="1">MASNRRLNPAMVIKKIIFTIVARNYYGLAQVLRQSIIKYNDDITFYAFIADGIPSDNRALFSADAIDVNVVMQHFVAPEKLQEMAFKYNLTEYCTAIKPFCFEYLFNQTDVDQIIYLDPDILVFSSLTPVFDCLQYASIVLTPHILFPSSLEGKRSDRGIMATGIYNLGFIGVCRSNTGFTFIRWWRQRLLDQCFIDSHDALFTDQKWADFIPGLFPSEDVCVLRHSGTNIAPWNFHEREVLITEEDSLVVRRRLDPNESLLLNNECKQEPIIFVHFSGFDYTLLCKGEAVQYNISGLSIYNDLQSLIDIYVASIQAQKETVLKFLGMTYGYESFQDGSLIISFHRRLYRSAVESGHNVGNPFSTDNHSFHSQLVKHKLLLNRAVVKKSDRSNKYNYPNLSDKLIIINRMMRVIRKIIGLENFLLLLRLMRPYSRAEAQLHNVYQNMNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W54</accession>
    <name>Q39W54_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome hibernation promoting factor</fullName>
            <shortName evidence="2">HPF</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">raiA</name>
        <name evidence="2" type="synonym">hpf</name>
        <name evidence="4" type="ordered locus">Gmet_1284</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with 100S ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365797.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1284"/>
    <dbReference type="EnsemblBacteria" id="ABB31520">
        <property type="protein sequence ID" value="ABB31520"/>
        <property type="gene ID" value="Gmet_1284"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1284"/>
    <dbReference type="eggNOG" id="COG1544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071472_0_3_7"/>
    <dbReference type="OMA" id="HGGYGVI"/>
    <dbReference type="OrthoDB" id="1766263at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00552">
        <property type="entry name" value="RaiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00839">
        <property type="entry name" value="HPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034694">
        <property type="entry name" value="HPF_long/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036567">
        <property type="entry name" value="RHF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003489">
        <property type="entry name" value="RHF/RaiA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032528">
        <property type="entry name" value="Ribosom_S30AE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038416">
        <property type="entry name" value="Ribosom_S30AE_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16321">
        <property type="entry name" value="Ribosom_S30AE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02482">
        <property type="entry name" value="Ribosomal_S30AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69754">
        <property type="entry name" value="SSF69754"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00741">
        <property type="entry name" value="yfiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Ribosom_S30AE_C" evidence="3">
        <location>
            <begin position="120"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="181" mass="20838" checksum="9DB8FA1B919F0AA6" modified="2005-11-22" version="1">MQITTTFRHMEQSDALKGYAAEKLERVKKYIDEPITAQVFLTVEKIRHMAEVTLTAKGVTIKAAEETNDMYAAIDAVVDKIERQLRRYKERLKNHKPAVDNRALEVQKTILTAESIDQQQEPVIVRSKTITIKPMSVEEAVMQMDLLHKDFLVFTDSTTEVINVVYRRKDGNYGLIEPSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WK5</accession>
    <name>Q39WK5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513395.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1131"/>
    <dbReference type="EnsemblBacteria" id="ABB31369">
        <property type="protein sequence ID" value="ABB31369"/>
        <property type="gene ID" value="Gmet_1131"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1131"/>
    <dbReference type="HOGENOM" id="CLU_803536_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="345" mass="35928" checksum="27585A305F2537C4" modified="2005-11-22" version="1">MGFFADVIRDSRREGLAVRAPEARVPRGGEEVPSDAPVAAEGAPVAPAAVTGSDASVIRLREEGGGTPVTAGQRLTQAGAVARQVVGPSLSEHTPVAGIPEAMVKGVTLPDPVKREQAGSESDRTAGGDFRVEQMGSFHDGGSIDVPLVPVGASDSFVRESSSGYAALQAVKVSVETQGRQQAGETRAGSTTPPGLMGSETVENPALGLPEEPLRADVEVFPALQLPGNPPMPATQADQSLQQGDVPEKTGRSAVPPGRESVEETNPAPSSGALPATVTLRQPPVTAVGEQFPRHSERQVAPPEPQVRIGTIEVVVVTPAPAERPSRSEERSRPDLSSRHYLRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WM0</accession>
    <name>Q39WM0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513770.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31354">
        <property type="protein sequence ID" value="ABB31354"/>
        <property type="gene ID" value="Gmet_1114"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1114"/>
    <dbReference type="eggNOG" id="ENOG503371J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100934_0_0_7"/>
    <dbReference type="OMA" id="ANEKARW"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="240" mass="28101" checksum="21CB659344D0D5DA" modified="2005-11-22" version="1">MIQDKTRRFFKIDVILVIIASISAFFMVKASDDYLPSSLNKTCIGRAILQFENGNQLIFNLAVGMLVGLFVYVLVSRLPERQKRIRIRNHLLRQYEAFRYETIRILVSAQGATYAGNLIEELMDKKSFRQYFETKVSESETRWSRVVNNFNDYCFRELSVEFDILISEILLAVHTIDIETEKVFSQINHIRHVSMYVKSLGQEYDDRKTLFRYLWSVNSGFSFEHGYAHPDIIEEAILAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WT4</accession>
    <name>Q39WT4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1050"/>
    <dbReference type="EnsemblBacteria" id="ABB31290">
        <property type="protein sequence ID" value="ABB31290"/>
        <property type="gene ID" value="Gmet_1050"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1050"/>
    <dbReference type="eggNOG" id="ENOG5033HU3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1692976_0_0_7"/>
    <dbReference type="OMA" id="MEDDFIF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="155" mass="17156" checksum="BDDC58BA7C974EF8" modified="2005-11-22" version="1">MVRLVRPVFEYVDIEVEAGEENEAVSAALAGAETIPADEWRGNFAAEEYGVDAVCVTESAGDDKEIFTEIAGEKKYLLLKADTDSGEGEVVYQPWIGEVSDLMLADLCSDWSGELAEAEEAGVAHYYDWAERYARFLKDGPAKVIQLRRPRGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WW2</accession>
    <name>Q39WW2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="5">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">narG-2</name>
        <name evidence="13" type="ordered locus">Gmet_1020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513191.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1020"/>
    <dbReference type="EnsemblBacteria" id="ABB31262">
        <property type="protein sequence ID" value="ABB31262"/>
        <property type="gene ID" value="Gmet_1020"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1020"/>
    <dbReference type="eggNOG" id="COG5013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_14_1_7"/>
    <dbReference type="OMA" id="DKPSQYF"/>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="12">
        <location>
            <begin position="26"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1204" mass="136142" checksum="C2C1BEF42E2A66A6" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WX7</accession>
    <name>Q39WX7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513175.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1005"/>
    <dbReference type="EnsemblBacteria" id="ABB31247">
        <property type="protein sequence ID" value="ABB31247"/>
        <property type="gene ID" value="Gmet_1005"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1005"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451830_0_0_7"/>
    <dbReference type="OMA" id="IATCDIT"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="393"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="320"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="604" mass="67897" checksum="467D69378AE7398F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XB8</accession>
    <name>AROA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
            <shortName evidence="1">EPSP synthase</shortName>
            <shortName evidence="1">EPSPS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroA</name>
        <name type="ordered locus">Gmet_0864</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EPSP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.19" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513010.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XB8"/>
    <dbReference type="SMR" id="Q39XB8"/>
    <dbReference type="STRING" id="269799.Gmet_0864"/>
    <dbReference type="EnsemblBacteria" id="ABB31106">
        <property type="protein sequence ID" value="ABB31106"/>
        <property type="gene ID" value="Gmet_0864"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0864"/>
    <dbReference type="eggNOG" id="COG0128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024321_0_1_7"/>
    <dbReference type="OMA" id="YEDHRMA"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00089"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000505">
        <property type="entry name" value="EPSPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="SSF55205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000325346" description="3-phosphoshikimate 1-carboxyvinyltransferase">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphoenolpyruvate" evidence="1">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>3-phosphoshikimate</name>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00210"/>
        </source>
    </evidence>
    <sequence length="429" mass="45624" checksum="9DFAE07D00EE8E69" modified="2005-11-22" version="1">MQSYTVRPAKGIRGEITVPGDKSISHRSIMLGSIARGETTVRGFLRGEDNIATLNAFRAMGVVIDDDGETLRIAGKGLRGLAEPTDVLDCGNSGTSMRLLTGLLAPQRFYSVLSGDQYLRRRPMRRVVEPLSRMGACIHGREGGEKAPLAIVGRDLKGISYTSSVASAQVKSALMLAGLYAEGETRVTEPHLSRDHSERMFRHFGADIENGPAGVVVRGGRELEGRDIIVPGDISSAAFFMVAALIVPGSELLIRGVGVNPTRTGIIDILTAMGGSLELLDQREVSGEPVADILVRSSRLKGIEIAGEVVPRAIDEFPVICVAAAVAEGRTVVREARELRVKETDRIAAMATNLRAVGVTVTESEDGMDIEGAEQIAAGTVESFGDHRIAMSMLIAGLTAGGDITVTDTECIGTSFPTFFPLLEKVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XC7</accession>
    <name>Q39XC7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein-export membrane protein SecF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secF</name>
        <name evidence="10" type="ordered locus">Gmet_0855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513000.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0855"/>
    <dbReference type="EnsemblBacteria" id="ABB31097">
        <property type="protein sequence ID" value="ABB31097"/>
        <property type="gene ID" value="Gmet_0855"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0855"/>
    <dbReference type="eggNOG" id="COG0341">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050012_0_1_7"/>
    <dbReference type="OMA" id="AFEWRMA"/>
    <dbReference type="OrthoDB" id="410730at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01464_B">
        <property type="entry name" value="SecF_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005665">
        <property type="entry name" value="SecF_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01755">
        <property type="entry name" value="SECFTRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00966">
        <property type="entry name" value="3a0501s07"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="302" mass="32723" checksum="3C3DBB5E4289986E" modified="2005-11-22" version="1">MEFIGKTHIDFMGMKKFSFAISIVIAILGIIGIVRIALGTANMGIDFSGGTAVQLKFAQPVHIDRAREALAKHGIHDANLQELKTGNKLLVKVGKTSLPQGNAADLIQTAFQKELTGNTFVVESSTEIGPAIGDKLRKDTLVAVAISMIGILIYIAWRFDFTFGVGALVATLHDVLAMFAVFFLLDKEVNLLFITAVLTIAGYSLTDTVVVFDRIRENLHKNTKDSLETIFNFSINEVLSRTIITALTTFLAAGSLYFFGGEVIHDFALALVVGILVGVYSSVFVASPIVEVWGRRPKASKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XC8</accession>
    <name>Q39XC8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein translocase subunit SecD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">secD</name>
        <name evidence="10" type="ordered locus">Gmet_0854</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SecD/SecF family. SecD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512999.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0854"/>
    <dbReference type="EnsemblBacteria" id="ABB31096">
        <property type="protein sequence ID" value="ABB31096"/>
        <property type="gene ID" value="Gmet_0854"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0854"/>
    <dbReference type="eggNOG" id="COG0342">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007894_4_3_7"/>
    <dbReference type="OMA" id="MVVYYRL"/>
    <dbReference type="OrthoDB" id="121331at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01463_B">
        <property type="entry name" value="SecD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005791">
        <property type="entry name" value="SecD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022813">
        <property type="entry name" value="SecD/SecF_arch_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022645">
        <property type="entry name" value="SecD/SecF_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022646">
        <property type="entry name" value="SecD/SecF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30081">
        <property type="entry name" value="PTHR30081"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07549">
        <property type="entry name" value="Sec_GG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02355">
        <property type="entry name" value="SecD_SecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00916">
        <property type="entry name" value="2A0604s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01129">
        <property type="entry name" value="secD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="398"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="533" mass="57805" checksum="21A4A209C99DB8C2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XD5</accession>
    <name>Q39XD5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512991.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0847"/>
    <dbReference type="EnsemblBacteria" id="ABB31089">
        <property type="protein sequence ID" value="ABB31089"/>
        <property type="gene ID" value="Gmet_0847"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0847"/>
    <dbReference type="eggNOG" id="COG4608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_7"/>
    <dbReference type="OMA" id="EPLRTYY"/>
    <dbReference type="OrthoDB" id="1303270at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="48"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="325" mass="35499" checksum="1E990374AB37BF4D" modified="2005-11-22" version="1">MTTPLIALENISKTFIVRPSPFTPSKVLRAVDGVSLRIGEGETLGLAGESGCGKSTVGKLLMGLLEADGGAIRFRGADMAGATADERAAFRKDVQMIFQDPFSSLNPRMRVGDIIGEPLAIHGLVPKERRRERVMELMEMVGLTAEQINRYPHEFSGGQRQRIGIARALAVSPRLIVADEPVSALDLSIQAQIINLLDELKRTLGLSYLFIAHDLSVVRHLSDRVAVMYLGRIVETGPRDAIFARFQHPYTEALLSAVPRITPSEGKKRIILKGDPPTPLNPPTGCPFHPRCPYAEPVCATSSPPLEEKRAGHLAACHFSHKLFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XF8</accession>
    <name>Q39XF8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31066.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514411.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31066">
        <property type="protein sequence ID" value="ABB31066"/>
        <property type="gene ID" value="Gmet_0824"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0824"/>
    <dbReference type="HOGENOM" id="CLU_176175_0_0_7"/>
    <dbReference type="OMA" id="INYFAGE"/>
    <dbReference type="OrthoDB" id="2039768at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31066.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="107" mass="12366" checksum="7B835989650E925B" modified="2012-10-31" version="2">MAIDTLHTRILGYFESEIEALRNHLETGQFKSFKDQVIAGLKIAEALDLLAPYARRNHRARRLVRKGKTLINDLLSVREVIRRGNSSPHLRQLLLISKVMSSERYLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XH3</accession>
    <name>Q39XH3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux pump, RND family, membrane fusion lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acrA</name>
        <name evidence="5" type="ordered locus">Gmet_0809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31051.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514396.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0809"/>
    <dbReference type="EnsemblBacteria" id="ABB31051">
        <property type="protein sequence ID" value="ABB31051"/>
        <property type="gene ID" value="Gmet_0809"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0809"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_2_1_7"/>
    <dbReference type="OMA" id="INVRYTK"/>
    <dbReference type="OrthoDB" id="1579676at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="66"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="3">
        <location>
            <begin position="296"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31051.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="395" mass="41771" checksum="9112F7368A89BCC8" modified="2012-10-31" version="2">MQAMYRTRLITVTGLLAIGMMVAGCGKKSNGAPPPSGPPEVGVVTIQPQRVELTTELPGRTSPHLIAEVRPQVSGIIQKRLFTEGSDVKAGQVLYQIDPSTYQAAFASAKATLARTEANLIPARLKEERFRDLVKIKAVSQQDYDDANAALKQAEADVASAKAAVETARINLGYTKVTAPISGRIGRSTVTDGALVTANQPTALATIQQLSSMYVDVTQSNADLLKLKQNLASGLMKHDGAAQARVKLLLEDGSPYPLSGTLKFSEVTVDQSTGSITLRAVFPNPKQTLLPGMFVRAIVEDGVSEQAILVPQRGVTRNPKGDATALVVGAENKVESRVIKVARTVGDNWLVSDGLKAGDRVILEGIQKAKPGTPVKAVPFGAKPETAPAPAVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XJ6</accession>
    <name>Q39XJ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter, periplasmic substrate-binding protein, MCE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513531.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0786"/>
    <dbReference type="DNASU" id="3738142"/>
    <dbReference type="EnsemblBacteria" id="ABB31028">
        <property type="protein sequence ID" value="ABB31028"/>
        <property type="gene ID" value="Gmet_0786"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0786"/>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107027_1_1_7"/>
    <dbReference type="OMA" id="QYQFPKD"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030970">
        <property type="entry name" value="ABC_MlaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04430">
        <property type="entry name" value="OM_asym_MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="37"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="16260" checksum="6F18B997542214C5" modified="2005-11-22" version="1">MKKVTLELIVGIFVAIGILCLGWLSVKLGKMELVGGDHYEVYAEFDSVSGLKEGAAVEIAGVEVGRVDRIALDPKFNDRARVSMRIANGVKLQDDVIASVRTSGIIGDKFILLKPGGSDNFLADNGRIRETESAVDLEELLSKYIHGKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XJ7</accession>
    <name>Q39XJ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux pump, RND family, outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0785</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513530.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0785"/>
    <dbReference type="EnsemblBacteria" id="ABB31027">
        <property type="protein sequence ID" value="ABB31027"/>
        <property type="gene ID" value="Gmet_0785"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0785"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037851_0_0_7"/>
    <dbReference type="OMA" id="AWFPKFE"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223418" evidence="3">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="453" mass="50218" checksum="898A21D9DCA61113" modified="2005-11-22" version="1">MRTLRAVALACLTALPLSGALAAEPATAPKTLSLDECIRGAIATAPELGESQADIELAQSRLEEAKGYRFPQIEMKALFGPVPEARGNQVWSPDGSNDTDSITWFARADATLVQPLYTFGKISENMKAATHGIEVDRAKKDQRRNEVALQTKEYYYGVLLAREMREVVLEVRENLDKARKKAQELLEKSSPNVEELDIYKLDAFNGEVGKYLAEADKGETLALSALRSRVGLPPEARIDIATERLVPDEGTAGDLPAYIDEARAKRPEFKQLKEGLQAREALVEAAKAAYYPDIFLAGLLSGAYSPERSRIDNPFITDEFNHFWTGIALGARWKLDFGITGSKVAGERAQYNRLLSTKVYADTNIPLQVKKAWLELKEAEKSIDATRDAYSNAKKWIVSAMANFDFGVGPAKELFDGLQNYARMRAGYFQSIYNQKMSRANLDYAVGAMPLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XL9</accession>
    <name>Q39XL9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sensor sigma-54-dependent transcriptional regulator, GAF and GAF domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513508.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0763"/>
    <dbReference type="EnsemblBacteria" id="ABB31005">
        <property type="protein sequence ID" value="ABB31005"/>
        <property type="gene ID" value="Gmet_0763"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0763"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013774_0_0_7"/>
    <dbReference type="OMA" id="HFLGKLY"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="554"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="936" mass="105610" checksum="105D67782897ABEB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XM1</accession>
    <name>Q39XM1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0761</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513506.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0761"/>
    <dbReference type="EnsemblBacteria" id="ABB31003">
        <property type="protein sequence ID" value="ABB31003"/>
        <property type="gene ID" value="Gmet_0761"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0761"/>
    <dbReference type="eggNOG" id="COG2768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046240_0_0_7"/>
    <dbReference type="OMA" id="MNHFKGH"/>
    <dbReference type="OrthoDB" id="1000643at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007160">
        <property type="entry name" value="DUF362"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04015">
        <property type="entry name" value="DUF362"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="186"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="368" mass="39210" checksum="38997667A5737A42" modified="2005-11-22" version="1">MPNTVYFADMRAGHKENLFDKIGKLMILAGVRERVSTGDLVAVKVHFGERGNHTFIRPIFIRRMVEEIKGCGGKPFLTDSSTLYPGERKEAVSALTCAVENGFAYAVAGAPLIMCDGLRGNSATVVEVNGEILKKVPIASAIAEADAMVAVSHFKCHELTGFGGALKNLGMGCSTREGKMTQHSTVAPKIAETYCTGCGLCLKACAHDAIAIIEGKAKLDPAHCAGCSRCITVCPTKAVQIQWNEAADLVMKKMAEFAKGAVVGKETKTLFINFITQVSPACDCYGHADAPIVNDIGICASTDPVALDQACADLVNDAQGNQNTALESGHEPGGDKFRGVHPDIDWEVQLVHAEKIGLGTREYELVKV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XN7</accession>
    <name>RUVA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvA</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvA</name>
        <name type="ordered locus">Gmet_0745</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvA family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514462.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XN7"/>
    <dbReference type="SMR" id="Q39XN7"/>
    <dbReference type="STRING" id="269799.Gmet_0745"/>
    <dbReference type="EnsemblBacteria" id="ABB30987">
        <property type="protein sequence ID" value="ABB30987"/>
        <property type="gene ID" value="Gmet_0745"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0745"/>
    <dbReference type="eggNOG" id="COG0632">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087936_0_0_7"/>
    <dbReference type="OMA" id="VGMAVQC"/>
    <dbReference type="OrthoDB" id="1370858at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009379">
        <property type="term" value="C:Holliday junction helicase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14332">
        <property type="entry name" value="UBA_RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00031">
        <property type="entry name" value="DNA_helic_RuvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013849">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvA_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000085">
        <property type="entry name" value="RuvA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011114">
        <property type="entry name" value="RuvA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036267">
        <property type="entry name" value="RuvA_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07499">
        <property type="entry name" value="RuvA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01330">
        <property type="entry name" value="RuvA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46929">
        <property type="entry name" value="SSF46929"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00084">
        <property type="entry name" value="ruvA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_1000002454" description="Holliday junction ATP-dependent DNA helicase RuvA">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00031"/>
        </source>
    </evidence>
    <sequence length="199" mass="21507" checksum="56A4EBB66586DB6D" modified="2005-11-22" version="1">MIARLTGMLAHKSPDAIIIDVNGVGYRVQIPFSTYYELPDEGKTVSLSIYTHVKEDAISLFGFRTVAEKEFFQVLISVSGIGPKMARDILSNIQPDELAGAILQGNLVRLSSIPGIGKKTAERLVLELKEKVRKMDVAPSTKEAAPSEAPPEVADDVASALVNLGYKEAVVRKVLAEMAIESGASTEAVLRQALKILMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XR6</accession>
    <name>Q39XR6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514621.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0716"/>
    <dbReference type="EnsemblBacteria" id="ABB30958">
        <property type="protein sequence ID" value="ABB30958"/>
        <property type="gene ID" value="Gmet_0716"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0716"/>
    <dbReference type="HOGENOM" id="CLU_449607_0_0_7"/>
    <dbReference type="OrthoDB" id="1446163at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223607" evidence="2">
        <location>
            <begin position="26"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="537"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="607" mass="63768" checksum="4303274A217C1042" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XU0</accession>
    <name>Q39XU0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Homocitrate synthase</fullName>
            <ecNumber evidence="4 7">2.3.3.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nifV</name>
        <name evidence="9" type="ordered locus">Gmet_0692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">This protein is a Fe-Mo-cofactor biosynthetic component.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>2-oxoglutarate + acetyl-CoA + H2O = (2R)-homocitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12929"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58884"/>
            <dbReference type="EC" id="2.3.3.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.14" evidence="4 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365709.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0692"/>
    <dbReference type="EnsemblBacteria" id="ABB30934">
        <property type="protein sequence ID" value="ABB30934"/>
        <property type="gene ID" value="Gmet_0692"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0692"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_4_2_7"/>
    <dbReference type="OMA" id="SNMFAHE"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004410">
        <property type="term" value="F:homocitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044249">
        <property type="term" value="P:cellular biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901566">
        <property type="term" value="P:organonitrogen compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd07939">
        <property type="entry name" value="DRE_TIM_NifV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013477">
        <property type="entry name" value="NifV/FrbC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02660">
        <property type="entry name" value="nifV_homocitr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="383" mass="41289" checksum="DCD4095E53FDCB48" modified="2005-11-22" version="1">MESATKNTVIIDDTTLRDGEQTAGVVFSKREKLAIARLLDDIGVQELECGIPAMGEEEREVIRALVDLGLNARLITWNRAVIPDIEASLACGVAAVDISLSVSDQMIAHKLRTSRDGVMEQLKRALGFAKEHDLYVSVGGEDASRADLGFLAELMEITCSMGGDRFRFCDTLGILDPFTMYEKVKALRAAAPGLDIEVHTHNDLGMATANALAGIKAGARFVNTTVNGLGERAGNAALEEVVMGLKLACGIDPGIDTHRFHEISRFVGRASQRPVPPWKAVVGERVFSHESGLHADGVIKDARNYEGFDPAEVGLCRHIVVGKHSGTSGLVERFRQMGIELSRQEAGALMDGVRAMAQRLKRPLSDGELRALHAAGRCALRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XV1</accession>
    <name>Q39XV1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FeMo cofactor biosynthesis protein NifB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nitrogenase cofactor maturase NifB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Radical SAM assemblase NifB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Gmet_0681</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; Fe-Mo cofactor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. NifB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514072.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0681"/>
    <dbReference type="EnsemblBacteria" id="ABB30923">
        <property type="protein sequence ID" value="ABB30923"/>
        <property type="gene ID" value="Gmet_0681"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0681"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027639_1_0_7"/>
    <dbReference type="OMA" id="PCYNEKL"/>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="UniPathway" id="UPA00782"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005980">
        <property type="entry name" value="Nase_CF_NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43787:SF3">
        <property type="entry name" value="PTHR43787:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="12">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB30923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="290" mass="31597" checksum="3C60816F902EAF8C" modified="2005-11-22" version="1">MATSCDQLKKIQGHPCFGGNHHKNGRMHLAVAPRCNIKCGYCTRRHDCANESRPGVTSRLITPAEAIAKVREVMASSVMGPIIKVIGIAGPGDPLANEETFETFRLVGEEFPHLMKCMSTNGLLLPDAIERLHQLDLHSLTVTLNALDPAVGARIYGHISYQGQVFRGVEAAEILVANQLEGIRRAVGYGMTVKVNTVYIPGVNEEQVPLIGRKIKELGAFVMNIMPLIPQADFAHISPPPPEELDRVRQRNESIIGQFKHCRQCRADAVGLIGRDATVTESGTPLTVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XW7</accession>
    <name>Q39XW7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0665</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30907">
        <property type="protein sequence ID" value="ABB30907"/>
        <property type="gene ID" value="Gmet_0665"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0665"/>
    <dbReference type="eggNOG" id="COG1746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962831_0_0_7"/>
    <dbReference type="OMA" id="ANSAWKR"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="291" mass="32668" checksum="96D2FCE09C1A8A82" modified="2005-11-22" version="1">MYLMTRTVNKGFHEFLHRIAPPRTEAESLKTLHSSVADFLRIGYGLNDFIITGSLRNGTCINGWSGYDYFAVMPTGKLKADSVATVSEIKNYLDFHLQDAEVRIQYPGIEVAVGAQGTTKVIPVDFVTEANGQKIYDMPDDTGGWMRTSPDAHGAYIKTIEQRLGVGGRNLMRLMKAWKYCGGVPISSFYLELAVAKYLEHASSVVYDVDVHGVFQYLFNNEMAPIEDPMGVSGCVNPCSAHSDYMTVKTELTAAFMRAARALEARLKYNVAEAFEWWRLLYNGKFPSYYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XX5</accession>
    <name>Q39XX5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ybhF-C1</name>
        <name evidence="6" type="ordered locus">Gmet_0657</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514265.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0657"/>
    <dbReference type="EnsemblBacteria" id="ABB30899">
        <property type="protein sequence ID" value="ABB30899"/>
        <property type="gene ID" value="Gmet_0657"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0657"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="QEFNVDR"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025302">
        <property type="entry name" value="DUF4162"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13732">
        <property type="entry name" value="DUF4162"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="320" mass="35669" checksum="BF41999BA6F046D7" modified="2005-11-22" version="1">MSDLAVTLRNLEKRFGDFVAVNRVSLDVKRGEIFGFLGPNGAGKSTTIRMLCGILQPTAGSGTVAGFDIVRQPEEIKKNIGYMSQKFSLYEDLTVEENIDFYSGIYRIPDAKKKERKEWVIRMAGLTEHRTSKTAILSGGWKQRLALGCAVLHEPPIIFLDEPTSGVDPVSRRNFWDLIYHLAGGGVTVFVTTHYMDEAEYCDRLALIYRGELIALGTPAELKTRFMEEEIVEVRCSQPQDAMETIEAIPGMGHTALFGRTLHVVAQRADEAIPAIQESLAAGGFTVDGIERIVPSLEDVFVSLIEARDRETAPQREFRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XZ3</accession>
    <name>RS14Z_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S14 type Z</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsZ</name>
        <name evidence="1" type="synonym">rpsN</name>
        <name type="ordered locus">Gmet_0639</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S3 and S10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XZ3"/>
    <dbReference type="SMR" id="Q39XZ3"/>
    <dbReference type="STRING" id="269799.Gmet_0639"/>
    <dbReference type="EnsemblBacteria" id="ABB30881">
        <property type="protein sequence ID" value="ABB30881"/>
        <property type="gene ID" value="Gmet_0639"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0639"/>
    <dbReference type="eggNOG" id="COG0199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139869_3_0_7"/>
    <dbReference type="OMA" id="RAYTRCN"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_B">
        <property type="entry name" value="Ribosomal_S14_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_S14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_S14/S29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_S14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023053">
        <property type="entry name" value="Ribosomal_S14_Z"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19836">
        <property type="entry name" value="PTHR19836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000269103" description="30S ribosomal protein S14 type Z">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01364"/>
        </source>
    </evidence>
    <sequence length="61" mass="7101" checksum="372A3D82BF2A41C7" modified="2005-11-22" version="1">MAKTSMIIKAQRGSKFKVREYNRCPLCGRPRAYYRKFDMCRICLRKLASTGQIPGVIKSSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y34</accession>
    <name>Q39Y34_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Anaerobic magnesium-protoporphyrin IX monomethyl ester oxidative cyclase-related enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0597</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512295.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0597"/>
    <dbReference type="EnsemblBacteria" id="ABB30840">
        <property type="protein sequence ID" value="ABB30840"/>
        <property type="gene ID" value="Gmet_0597"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0597"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_0_7"/>
    <dbReference type="OMA" id="GNWPPAW"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="191"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="501" mass="56978" checksum="7D1D723E859DA1A9" modified="2005-11-22" version="1">MKIKRIALITPPYHAGVVESAGTWLNVGFVYIAGALRAAGYEVDYYDAMSLWHKWPDIQKRIEAFRPDMVATTAYTASIVEAVKLLRFAKSINPRIVTALGNVHAAFCYDEVLTHDHDAVDYIVRGEGEETLPMLCHCLNAGDDPKKVLGIAYWRDGGVVVTPKAPYIHDLDNLPTAWDLVEWPIYTYRAKKNARLAIVSSSRGCKSQCSFCSQQLFWAQSWRARSAENFVAELEMLHNVHGVQVAMLSDELPTFDRERWVRILDLMVEREVPVKLLMETRVDDILRDADIMDKYREGGVEHIYVGVEAGSQETLDLFKKDTEVAQSKQAIDLINGADIVSETSFVLGMPDDTPESIEQTIELAKHYNPDMAFFLAIAPWPYAELYPELEPYVATKDYRKYNLVEPVIKPKNMTMEELERQLGKASQKFFMHKFQNLDKLSPWKQEFMLSVLDLLINHSYLAGQMKAMLKEGKEMPAEVKALLKTVSQHKHVPHQTIAPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y48</accession>
    <name>Q39Y48_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Spermine/spermidine synthase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0583</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0583"/>
    <dbReference type="EnsemblBacteria" id="ABB30826">
        <property type="protein sequence ID" value="ABB30826"/>
        <property type="gene ID" value="Gmet_0583"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0583"/>
    <dbReference type="eggNOG" id="COG4262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010122_1_0_7"/>
    <dbReference type="OMA" id="IFMGGMA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006596">
        <property type="term" value="P:polyamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="239"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="367"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="570"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="837" mass="91112" checksum="F1A03A298B4C9E53" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y92</accession>
    <name>Q39Y92_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Menaquinol oxidoreductase complex Cbc6, cytochrome b subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbcP</name>
        <name evidence="3" type="ordered locus">Gmet_0539</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512235.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0539"/>
    <dbReference type="EnsemblBacteria" id="ABB30782">
        <property type="protein sequence ID" value="ABB30782"/>
        <property type="gene ID" value="Gmet_0539"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0539"/>
    <dbReference type="eggNOG" id="COG1290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031114_0_1_7"/>
    <dbReference type="OMA" id="WATQTGM"/>
    <dbReference type="OrthoDB" id="1339825at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13631">
        <property type="entry name" value="Cytochrom_B_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="2">
        <location>
            <begin position="1"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="206" mass="22829" checksum="D211D1C611AE46FF" modified="2005-11-22" version="1">MIKEFAKHLFPRVVLRENLRFTYTFCLGGLAFTALIALAVSGVLLLFYYQPTPAGAFDSILFLESTVVGGKYLRGLHRLASHGLLVLLFLHVLRVVLSGAYRPPRELTWVVGVGLLALSVFEAYTGYLLPMDQLAFWATRTGMELLATLPGGPWLKAVLVPDGVGEPLSLLRFYALHVVVVPVAVLALSFLHFYRVRKTKGILPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YA9</accession>
    <name>Q39YA9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0522</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512218.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0522"/>
    <dbReference type="EnsemblBacteria" id="ABB30765">
        <property type="protein sequence ID" value="ABB30765"/>
        <property type="gene ID" value="Gmet_0522"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0522"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_3_1_7"/>
    <dbReference type="OMA" id="NACDVIC"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="113" mass="12573" checksum="72F820E4F16E97AF" modified="2005-11-22" version="1">MKQAARLFKSLADETRLRILALLLAEKKLCVCDLMAALELPQSTVSRHLAQLKNAGWVDDRREGVWVYYSLAPSDIPARGELQAFLARYLATEPVALADRERLAGFGQGNRCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YH0</accession>
    <name>Q39YH0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Flagellar basal body stator protein MotA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">motA</name>
        <name evidence="11" type="ordered locus">Gmet_0461</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MotA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513830.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0461"/>
    <dbReference type="EnsemblBacteria" id="ABB30704">
        <property type="protein sequence ID" value="ABB30704"/>
        <property type="gene ID" value="Gmet_0461"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0461"/>
    <dbReference type="eggNOG" id="COG1291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079895_0_0_7"/>
    <dbReference type="OMA" id="ANLIWLN"/>
    <dbReference type="OrthoDB" id="897037at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097588">
        <property type="term" value="P:archaeal or bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000540">
        <property type="entry name" value="Flag_MotA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01307">
        <property type="entry name" value="MOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="10">
        <location>
            <begin position="100"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="254" mass="27099" checksum="32952D870D406CB2" modified="2005-11-22" version="1">MDIATIIGLVMGFGAVIGGALIEGLHLGALIQPTAALIVLGGTFGAAFVSYPMKTIIGAVKDIRKVLFPAQHDPEKVIKEIIGYAAKARRNGLISLEQEAQNVKDAFTKKGISLVVDGIDPQKLRETLEIEIAYYEEHSKQSAEFFEAAGGYAPTIGIIGAVLGLIHVMANLSDSSKLGAGIAVAFVATIYGLMTANIVCLPFGTKIKHGIKEELICKNMIIEGLIAIQNGENPHFIEQKLKAFIQEGDEKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YI3</accession>
    <name>Q39YI3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_57 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0448</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365670.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0448"/>
    <dbReference type="CAZy" id="GH57">
        <property type="family name" value="Glycoside Hydrolase Family 57"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30691">
        <property type="protein sequence ID" value="ABB30691"/>
        <property type="gene ID" value="Gmet_0448"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0448"/>
    <dbReference type="eggNOG" id="COG1449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_413731_0_0_7"/>
    <dbReference type="OMA" id="VVVEWDN"/>
    <dbReference type="OrthoDB" id="492432at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004300">
        <property type="entry name" value="Glyco_hydro_57_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03065">
        <property type="entry name" value="Glyco_hydro_57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_57" evidence="1">
        <location>
            <begin position="39"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="659" mass="74500" checksum="EAB3327354AA1A84" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YP2</accession>
    <name>HIS6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazole glycerol phosphate synthase subunit HisF</fullName>
            <ecNumber evidence="1">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IGP synthase cyclase subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">IGP synthase subunit HisF</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ImGP synthase subunit HisF</fullName>
            <shortName evidence="1">IGPS subunit HisF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisF</name>
        <name type="ordered locus">Gmet_0389</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512361.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YP2"/>
    <dbReference type="SMR" id="Q39YP2"/>
    <dbReference type="STRING" id="269799.Gmet_0389"/>
    <dbReference type="PRIDE" id="Q39YP2"/>
    <dbReference type="EnsemblBacteria" id="ABB30632">
        <property type="protein sequence ID" value="ABB30632"/>
        <property type="gene ID" value="Gmet_0389"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0389"/>
    <dbReference type="eggNOG" id="COG0107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_4_0_7"/>
    <dbReference type="OMA" id="IFHYKET"/>
    <dbReference type="OrthoDB" id="1522718at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01013">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000230128" description="Imidazole glycerol phosphate synthase subunit HisF">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01013"/>
        </source>
    </evidence>
    <sequence length="253" mass="27596" checksum="08E511D8C207C1FC" modified="2005-11-22" version="1">MLTKRIIPCLDVKGGRVVKGVQFLELRDAGDPVEIAEAYDRQGADELTFLDITASSDERNIIIDVVRRTAERVFMPLTVGGGVRIVDDIRNLLNAGADKVSINTAAVHRPEFVREAAERFGSQCTVVAIDARQVPGENRWEVYTHGGRNPTGIDAVEWARRMEEYGAGEILLTSMDRDGTKDGYDISLTRAIVDAVSIPVIASGGVGNLEHLHDGFVKAGASACLAASIFHYKEYTIGEAKEYLRGRGVPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YR9</accession>
    <name>Q39YR9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Single-stranded DNA-binding protein</fullName>
            <shortName evidence="2">SSB</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ssb</name>
        <name evidence="6" type="ordered locus">Gmet_0362</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512334.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0362"/>
    <dbReference type="EnsemblBacteria" id="ABB30605">
        <property type="protein sequence ID" value="ABB30605"/>
        <property type="gene ID" value="Gmet_0362"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0362"/>
    <dbReference type="eggNOG" id="COG0629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078758_0_2_7"/>
    <dbReference type="OMA" id="GQMQERT"/>
    <dbReference type="OrthoDB" id="1942216at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00984">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="PTHR10302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00621">
        <property type="entry name" value="ssb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1 2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="102"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Important for interaction with partner proteins" evidence="2">
        <location>
            <begin position="142"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="16028" checksum="4A7EB170D36F2C21" modified="2005-11-22" version="1">MASLNKVMLIGNLGKDPEVRYTPGGTAVASFSLATSEKFKNRNGEFEEKTEWHNVVLWGRQAEIAGEYLAKGRTVFIEGRLQTRKWQDKEGRDRWSTEVVGERMQMLGGKGEGGGGRSGGRGGQEGGFGGGPAYDEPAFNPDDDIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YS8</accession>
    <name>Q39YS8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0353"/>
    <dbReference type="EnsemblBacteria" id="ABB30596">
        <property type="protein sequence ID" value="ABB30596"/>
        <property type="gene ID" value="Gmet_0353"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0353"/>
    <dbReference type="eggNOG" id="COG2067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_825761_0_0_7"/>
    <dbReference type="OMA" id="DFALWLT"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021523">
        <property type="entry name" value="DUF3187"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11383">
        <property type="entry name" value="DUF3187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="348" mass="37871" checksum="7C8B6ECE9FB9CBD7" modified="2005-11-22" version="1">MAMNGSSGKRTGTWRIRAGAAMAGLALLLTGTVARGMEVTPFRTGNMAPLVQIHGLPVPDSARILASREGEVSAVADLSNNYAVDSKGNEHIILDGETYRFALDLRYGLVPGVEAGIEIPFIVQSGGFLDGFIEWFHKAFGFTNGGREYAPRDRLRYRYDTNGTDRFRIDDSNAGIGDIRLTGGIQLYDDGATAPRRVALRSALKLPTGDSDKLRGSGSVDFALWLAASDDYRLGDWGHLTLFANAGGTVMGDGDVLGDQQRNLAAMGTFGFGWSPLDWMALTVQTTWHSSLYEGSDLREISTNSLLMTGGFSFAFTERTFFDIALSEDLNVKTSPDVNFHLALRQRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YU2</accession>
    <name>Q39YU2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sigma-54-dependent sensor transcriptional regulator, PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_0339</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512311.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0339"/>
    <dbReference type="EnsemblBacteria" id="ABB30582">
        <property type="protein sequence ID" value="ABB30582"/>
        <property type="gene ID" value="Gmet_0339"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0339"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_8_1_7"/>
    <dbReference type="OMA" id="ADHENRI"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="9">
        <location>
            <begin position="83"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="147"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="459" mass="50779" checksum="B6DA24B8B52DFEB7" modified="2005-11-22" version="1">MGSEKGTIDPAVYRAILASMGDGIVFLDTEDCFAYINAAAEKIRGIRAENYLGRHILSIFGTHSNHTSERVRKLLAALRSGVLPFHVHIIETRGRVFENSYYPIRDKGGNYLGTLMMSRDITEKERLKAENLTLREQVLSEFGCCDLVGSSDVMRPIFQIINAAAAVDSTILITGESGTGKELVARAVHQHSARKDLPMIKVNCAALPDTLLESELFGHEKGAFTGAIKERKGKFEQAHGGTIFLDEIAEMPLAAQAKLLRVLQERTVERLGSTREIRVDVRIIAATNRDLRREVTAGRFREDLFYRLNVIPIHIPPLRERTEDILALARQFLNRFAEKMHKPVMEIAPEAQKALLEYNYPGNVRELENAVERAVALSLGSNLRLGDLPSEFTAPHPAGAQPLSPSAGPASLADSVHSMEKNAIEEALRSTGNKKGDAARLLGISRKTLWEKMKQLGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YV9</accession>
    <name>Q39YV9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30565.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30565">
        <property type="protein sequence ID" value="ABB30565"/>
        <property type="gene ID" value="Gmet_0322"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0322"/>
    <dbReference type="HOGENOM" id="CLU_1169331_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223457" evidence="1">
        <location>
            <begin position="23"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30565.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="237" mass="26347" checksum="9A5C99BA49F98E03" modified="2012-10-31" version="2">MKNLSFCCLLACVLLTILCGCANPRQVMVNPNTWQQTVCASSGWGWLGAPLAYKNYNNCVNNQKVLGLIPLEELEAKDTPRFDTLIDATDKKAARPEWQAGQFWEYSLSSGGTSRLTVQKIGSYNGTAGYNVFNANGRESFYDQSLGLMIVFGSGGVETEYDPALRPFDFPLFLSKSWNATGDMHRSGGHIDLSNHHEVKGYGRIKVPAGEFDAFYILNRSDYGARISELWYSPEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YW8</accession>
    <name>Q39YW8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0311"/>
    <dbReference type="EnsemblBacteria" id="ABB30556">
        <property type="protein sequence ID" value="ABB30556"/>
        <property type="gene ID" value="Gmet_0311"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0311"/>
    <dbReference type="HOGENOM" id="CLU_1072662_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="259" mass="29722" checksum="F193381C1E9B51DE" modified="2005-11-22" version="1">MGKILELVGGPPASGKTTYIRTNYETKGSGEFVHLDYDAMVVKEAGRCRGDVQEQDVRDHVSMVYGRERSTVIYGDAGRVTVDWPFCVSKRAEEYISIGRNAGRHIECNFFTAQATEAWKRSLTRHVAGEYNAFTVFLNKHADIGESLRPSFQDFLEAHRDMPASVERIFPQADVAYLWDNNERDAVPVLIATCKKGEKIHVIDQGRWDRFQYKREIDIDAEFEVLDSRVEEFQGKPRTLFKVQYANVIRSGREKEFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YY4</accession>
    <name>Q39YY4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c nitrite and sulfite reductase, menaquinol-oxidizing subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nrfH</name>
        <name evidence="5" type="ordered locus">Gmet_0295</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514006.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0295"/>
    <dbReference type="EnsemblBacteria" id="ABB30540">
        <property type="protein sequence ID" value="ABB30540"/>
        <property type="gene ID" value="Gmet_0295"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0295"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096753_0_1_7"/>
    <dbReference type="OMA" id="ACINCHV"/>
    <dbReference type="OrthoDB" id="1683334at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3820.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005126">
        <property type="entry name" value="NapC/NirT_cyt_c_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038266">
        <property type="entry name" value="NapC/NirT_cytc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017571">
        <property type="entry name" value="NrfH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03264">
        <property type="entry name" value="Cytochrom_NNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03153">
        <property type="entry name" value="cytochr_NrfH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_NNT" evidence="4">
        <location>
            <begin position="13"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="153" mass="17148" checksum="3A4889E21C05F55F" modified="2005-11-22" version="1">MGLPGTGNQAIYLAIGVIVAAVALFVLFGPPKLLAKSDTPDFCVGCHPMENEYEAWIHTGAHRRVKCVDCHLPNENLAVHYIWKSIDGAKDAIFFYSGHVPEIIRLSKHGEEVLQKNCVRCHDTTVTHIDTERQCWKCHRRVSHTRSGAMETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YZ2</accession>
    <name>Q39YZ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0287</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513998.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0287"/>
    <dbReference type="EnsemblBacteria" id="ABB30532">
        <property type="protein sequence ID" value="ABB30532"/>
        <property type="gene ID" value="Gmet_0287"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0287"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694003_0_0_7"/>
    <dbReference type="OMA" id="DCESIAC"/>
    <dbReference type="OrthoDB" id="809169at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="378" mass="40792" checksum="06603C738DC314CC" modified="2005-11-22" version="1">MASQSRNQPDKTVTDRVVITGIGTVTSLGCSQWSTALALRFRKSSWCEHETVLVADDPYGAVLRGATISRIPEEIISPELDGAERAEALFHPALKECMAGLSIAEQKRLVCRIDNFIDYEQHLFPSLLQEAFPGLSLEHGQKPIELGRCSLFERIIQAGGELLAGNAERILVGCVDSLCATSWLMSVCDEDVLKDSLTPEGIIAGEAAGAVLLEREAAARRRNAPVLAILSSWGRGTEPNLWHGPIPSTGRGLTDAFLEAISPHGDGGKGVVTVIADLNGDRHRALDWAYTEGRIFIDGDREPELRHPAFIAGDCGKATGALLLADALGRFAFHPGFRGTLALSTSDESGARRVICLEHGDHEERKGFIEQLRAQLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z31</accession>
    <name>Q39Z31_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sco</name>
        <name evidence="4" type="ordered locus">Gmet_0248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCO1/2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30493.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513564.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0248"/>
    <dbReference type="EnsemblBacteria" id="ABB30493">
        <property type="protein sequence ID" value="ABB30493"/>
        <property type="gene ID" value="Gmet_0248"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0248"/>
    <dbReference type="eggNOG" id="COG1999">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058434_2_0_7"/>
    <dbReference type="OMA" id="YIFGFIR"/>
    <dbReference type="OrthoDB" id="1994201at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02968">
        <property type="entry name" value="SCO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003782">
        <property type="entry name" value="SCO1/SenC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12151">
        <property type="entry name" value="PTHR12151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02630">
        <property type="entry name" value="SCO1-SenC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223464" evidence="3">
        <location>
            <begin position="33"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30493.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="292" mass="32259" checksum="852038DE4140AA7F" modified="2012-10-31" version="2">MAWLHGPRWTAFRCFLSIMLVAFALLPAPATAHTEEDLHKHGPFGTDAGAGDAAKFGLTERLGEKIPLDLTFRDETGAPVRLAALVTVPTIILPVYYSCTNVCNFLQGGLASVLKDVRQRPGEEYRVISVSFDETETPELATKYKRTYLASMNAPFPENGWRFLTGDAKNIRRLTDAAGFRFERRGRDFIHPVASIIVARDGTIVRYLYGTTFLPKDLSLALLEARSGKVGATIRQVVGYCFTFDPQAKTYVFNLLRVSATIVIISTGAFLAFLFLTGKKRPASPRGGHETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z38</accession>
    <name>Q39Z38_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365638.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0241"/>
    <dbReference type="EnsemblBacteria" id="ABB30486">
        <property type="protein sequence ID" value="ABB30486"/>
        <property type="gene ID" value="Gmet_0241"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0241"/>
    <dbReference type="eggNOG" id="ENOG502ZA96">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879289_0_0_7"/>
    <dbReference type="OMA" id="MVQMANE"/>
    <dbReference type="OrthoDB" id="1328098at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025491">
        <property type="entry name" value="DUF4382"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14321">
        <property type="entry name" value="DUF4382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223530" evidence="1">
        <location>
            <begin position="19"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4382" evidence="2">
        <location>
            <begin position="40"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="316" mass="33337" checksum="20926F22019FF02E" modified="2005-11-22" version="1">MMVQMRSALKTMVFFAVATLALVQFQGCSGGGGGGGTASTGTLKVALTDKLSDDFAEVRIKIKAVKIVPVEYDQNASDDDPLLITIPLAEPSPSFNVLDLAYVQELLGTVTLPVGTYSQVRLILEPNVNGQNPVNYVTLKSDPNTKIPLKTPSAQQSGLKVLGRFVVEPGVINAIAIDFDPNTAIVERGNTPQNEKYILKPTGIRIIQMEDVIPAYGSISGTVVSPFADWSSATVSVKRRGAINDVNPIAAGTIFSNYTSGTWQAPFAVFVPPSTATVAYKAFVAANGFQLYSSAAVSVASKATTDLGAIHLTPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z39</accession>
    <name>Q39Z39_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix and zinc ribbon transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513556.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0240"/>
    <dbReference type="EnsemblBacteria" id="ABB30485">
        <property type="protein sequence ID" value="ABB30485"/>
        <property type="gene ID" value="Gmet_0240"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0240"/>
    <dbReference type="eggNOG" id="COG3357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162441_0_0_7"/>
    <dbReference type="OMA" id="LVAPPEC"/>
    <dbReference type="OrthoDB" id="1944426at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038767">
        <property type="entry name" value="Transcriptional_reg_pdt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40663">
        <property type="entry name" value="PTHR40663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="115" mass="13039" checksum="03CB80053783D631" modified="2005-11-22" version="1">MKQIPRKPAVPRPAQETARHAVMELIRDHPLSAREISSQAHLAEKEVYSHLEHIRLSIHASGGYLEVTPAECRACGFVFAKRDRLTSPGKCPVCRDEFIFEPLFAIRQRQGHGQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z79</accession>
    <name>Q39Z79_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Twitching motility pilus retraction ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pilT-1</name>
        <name evidence="4" type="ordered locus">Gmet_0199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512788.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0199"/>
    <dbReference type="EnsemblBacteria" id="ABB30445">
        <property type="protein sequence ID" value="ABB30445"/>
        <property type="gene ID" value="Gmet_0199"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0199"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_7"/>
    <dbReference type="OMA" id="APPCAKF"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="387" mass="42658" checksum="377BDB219E43DFF5" modified="2005-11-22" version="1">MELNDILAIAVKAKASDIHIKTGLPPVVRIDGRLRPIPNAQRLAPDQVRAMAFAIMNERQKGIFEEHYECDVAYGVPGLGRFRVSIYSQRGTVAMVFRSIPFGIPSIENLTLPPVIKKLALEERGLILVTGTTGSGKSTTLAAMIDYINEHRTCNIITVEDPVEFLHRDKKSILSQREVGFDTLSFSTALKGALRQDPDVVLVGEMRDLETIETAMHAAETGHLVMSTLHTLDAAETINRIISVFPPFHQRQVRLQLSGVIKGVISQRLVPRADGKGRVPAVEVMIGTARIKEYIDDKDKTKLLPEAIAQGFTTYGMQTFDQSLMQLYTGKLITYEEALRQSTNPDDFALKVSGISSTSDSTWDNFVHDEAPPAAAGDTPTEGIEKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZB4</accession>
    <name>NUOI1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit I 1</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit I 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit I 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoI1</name>
        <name type="ordered locus">Gmet_0163</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30410.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365630.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZB4"/>
    <dbReference type="SMR" id="Q39ZB4"/>
    <dbReference type="STRING" id="269799.Gmet_0163"/>
    <dbReference type="EnsemblBacteria" id="ABB30410">
        <property type="protein sequence ID" value="ABB30410"/>
        <property type="gene ID" value="Gmet_0163"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0163"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_4_3_7"/>
    <dbReference type="OMA" id="VDTPHAI"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000245707" description="NADH-quinone oxidoreductase subunit I 1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 2" evidence="1">
        <location>
            <begin position="87"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <sequence length="176" mass="19943" checksum="FD165C4D0DA41A99" modified="2013-07-24" version="2">MPIITDFKAIATGLFVTWKHIFRRSVTVEYPEVKRTPAPRYRARIVLTRDPEGGERCVACYLCSAACPVDCISMEATEDGNGRRYARWFRINFSRCIFCGLCAEACPTLAIQMTPDYEICERDIMELVYEKEDLLIDGCGKDPAYNFYRHAGIGVTQPRGAGEREEEPVDARGLMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZM4</accession>
    <name>Q39ZM4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514175.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0051"/>
    <dbReference type="EnsemblBacteria" id="ABB30300">
        <property type="protein sequence ID" value="ABB30300"/>
        <property type="gene ID" value="Gmet_0051"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0051"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053995_0_0_7"/>
    <dbReference type="OMA" id="PDHLWSA"/>
    <dbReference type="OrthoDB" id="688156at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="353" mass="39490" checksum="9E96D35A15785075" modified="2005-11-22" version="1">MNVEQMKTVLREILTRTDLTPCVVGHRGVGKTAGIVQLCRELGSSYVPLRLGQMEVGDLVGIPYREGEVMNWSRPCWWPADDEPATVIHCDELNRAQQEDTLQAIFQFVEPPAEGMRRALHTHSLHPKHKVVVTINPSDGTYQVATLDRALIDRMVMLYVETDYHCWAGYAAARDLDTGVRHFLAANSMFLASQGSPLEMDAEPTERGWEMVSILRKSCRFPRDLEMEIYAGIVGKEAAIAFLRWCAENTRRPVTAVEVLNGGDGVRERLEAQRDDLQASTMGDIVATLTADPRLGAEQEENLVRYIDILPRDMRFGLVKSLLKIPPVAQAISQDKYDAVVFDAIRTISAEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZQ2</accession>
    <name>Q39ZQ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513788.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0022"/>
    <dbReference type="EnsemblBacteria" id="ABB30272">
        <property type="protein sequence ID" value="ABB30272"/>
        <property type="gene ID" value="Gmet_0022"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0022"/>
    <dbReference type="eggNOG" id="COG1916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432579_0_0_7"/>
    <dbReference type="OMA" id="WQKRAFF"/>
    <dbReference type="OrthoDB" id="250542at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="654" mass="75555" checksum="C4DB1F1893556DCF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEM2</accession>
    <name>J9JEM2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3582"/>
    <dbReference type="EnsemblBacteria" id="AFR42796">
        <property type="protein sequence ID" value="AFR42796"/>
        <property type="gene ID" value="Gmet_3582"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3582"/>
    <dbReference type="HOGENOM" id="CLU_2355705_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="96" mass="10859" checksum="52C56549DB21CFBA" modified="2012-10-31" version="1">MSNIKSLPFRQAFLRHHKLCVGTRQLPLAVPLLPPRPVFLPEPGHVTFPTHPLPQGNVIPVPRSSLPQRLSLISLLLSHGYVFLFRPELLVRHLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEM7</accession>
    <name>J9JEM7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3593</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3593"/>
    <dbReference type="EnsemblBacteria" id="AFR42809">
        <property type="protein sequence ID" value="AFR42809"/>
        <property type="gene ID" value="Gmet_3593"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3593"/>
    <dbReference type="HOGENOM" id="CLU_3099256_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="51" mass="5597" checksum="4BC1850BA72E239C" modified="2012-10-31" version="1">MVGKSRMWLYVNAVLNWCRLAFCSGTVVMLWNTTPPCHLAGAPFGRSPAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEN3</accession>
    <name>J9JEN3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365849.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFR42824">
        <property type="protein sequence ID" value="AFR42824"/>
        <property type="gene ID" value="Gmet_3605"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3605"/>
    <dbReference type="eggNOG" id="ENOG5033HZ5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1967385_0_0_7"/>
    <dbReference type="OMA" id="FMATPCL"/>
    <dbReference type="OrthoDB" id="2051106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="129" mass="13435" checksum="98C00F66893905D5" modified="2012-10-31" version="1">MDRAHRGVWGVITFLLLVIWCTPCMADDAFESIFRNAFLGGLVGGVAGAAFLALADKPGDHLDYIGYGAAGGVLAGAAYGSIKTTRALAEVDNGKVKLAVPTIVPGFVPVGTKGEREVVLTAEVLRGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-06-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEP4</accession>
    <name>J9JEP4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3636"/>
    <dbReference type="EnsemblBacteria" id="AFR42851">
        <property type="protein sequence ID" value="AFR42851"/>
        <property type="gene ID" value="Gmet_3636"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3636"/>
    <dbReference type="HOGENOM" id="CLU_211497_0_0_7"/>
    <dbReference type="OMA" id="MTLGHDD"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFR42851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="51" mass="6244" checksum="9194BF1FDDC97B47" modified="2012-10-31" version="1">MGDERNELDELSREIRKVIENNRKFLDHVMDEDFEPEETEETKDEDVFEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PT8</accession>
    <name>Q39PT8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Chaperone protein DnaJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">dnaJ</name>
        <name evidence="12" type="ordered locus">Gmet_3531</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 2 Zn(2+) ions per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DnaJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513687.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3531"/>
    <dbReference type="EnsemblBacteria" id="ABB33736">
        <property type="protein sequence ID" value="ABB33736"/>
        <property type="gene ID" value="Gmet_3531"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3531"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_7_7"/>
    <dbReference type="OMA" id="DLHCTVT"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="SSF57938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02349">
        <property type="entry name" value="DnaJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="10">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="11">
        <location>
            <begin position="135"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="8">
        <location>
            <begin position="148"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="8">
        <location>
            <begin position="165"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="8">
        <location>
            <begin position="187"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="CXXCXGXG motif" evidence="8">
        <location>
            <begin position="201"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="9">
        <location>
            <begin position="135"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="372" mass="40525" checksum="3473CF582D16067B" modified="2005-11-22" version="1">MAEKRDYYEVLEVHRNASDTEIKKAFRKLAIQYHPDKNPGDKESEEKFKEITEAYEVLSDSQKRAQYDQFGHAGLGAGGFSSGGFGGFGAGTPFGDIFGDIFGDIFGGRPRGSRGRRGDDLQYNLELSFEEAAFGVEKEILVPFGKRCDECGGSGAKPGTEPKVCPTCRGAGQVRFQQGFFSVSKTCSHCNGEGRVVENPCPTCRGNGMVRDTKTLSVKVPAGVETGTRLKMTGEGGQGTKGGGNGDLYVAIAVKEHPIFTREDNDVICEIPISFVQAALGCEMEVPTLDGKVSMKVPEGTQSGRIFRLRGKGVPQLQGYGRGDQMVVVKVETPSNLNKRQRELLEEFARISGEDAHPMKKNFFDKVMDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PV3</accession>
    <name>Q39PV3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peroxiredoxin-like 2 family protein, selenocysteine-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3516"/>
    <dbReference type="KEGG" id="gme:Gmet_3516"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_5_0_7"/>
    <dbReference type="OMA" id="AWCPYCN"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <keyword evidence="2" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="52"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="2">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="230" mass="25543" checksum="0A585C84CEDE3289" modified="2008-02-26" version="2">MDGEQPTFIFELQKELDAIRENFRATASPDVVTAMDRSAEELIRAGIVERALQVGSPAPDFALPNAVGREVRLSSVTARGPSVITFYRGAWUPYCSLQLRAYQKILPQLKLLGGELLAISPQTPDKTQATLLKNFLEYEVLSDVGNRVAKRFGLVYPVGAEVRRIYLGFGVDLAEYNGDDSWELPLPGTFVIDRTMTVRLSFVDADYTRRLEPAAILDTLRAMRDVGGIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PW9</accession>
    <name>Q39PW9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3500"/>
    <dbReference type="EnsemblBacteria" id="ABB33705">
        <property type="protein sequence ID" value="ABB33705"/>
        <property type="gene ID" value="Gmet_3500"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3500"/>
    <dbReference type="HOGENOM" id="CLU_2259773_0_0_7"/>
    <dbReference type="OMA" id="CQIAPFL"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="111" mass="12355" checksum="B835CD1EEF5CA98E" modified="2005-11-22" version="1">MKEWRVSLADKRVLWPVIVTVSLVLVFLGTRTPNIARPQKPTSRPRAVIETQVKTTQAGIEKHGQAVELCHRAEFFNVSAPRVSAVHFEPHKIVSSVLCFISARAPPLAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q00</accession>
    <name>Q39Q00_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux pump, RND family, outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3465</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513916.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3465"/>
    <dbReference type="EnsemblBacteria" id="ABB33674">
        <property type="protein sequence ID" value="ABB33674"/>
        <property type="gene ID" value="Gmet_3465"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3465"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_6_7"/>
    <dbReference type="OMA" id="EAAFMPK"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223127" evidence="3">
        <location>
            <begin position="20"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="441" mass="48759" checksum="15CE46376AF125BA" modified="2005-11-22" version="1">MKRLVILMGMVLLPHGVFAEAGVPAFALSRVIDFALENEPKLSVLGKDIEAAKHTVDAAKGGRWPRLDLEAGITRYRYAAPITPISGAPQNGGGFPPFDKDIYDASLTLKLPIYRGGRLVKNVEIAEINRLIAERALHQGRQELVFNVTSVYCKILELEELLKAHEQNVRQLEEHRRVTEQFVKAGSAARVDLMKTDVELAHGRQQVLATQNAGAAAYALLRSLMGVDESYPRFTVAEEPFPEKGYPPEEKAVEVALRQRPDYLKVKARTELFQARLDLARGKRLPSVDVAGEYGERAGDSLSFKENWNIGLRLSYPLFDGGITRAEIKKGMVELERTGEELRAVRLSIVREVREAYLAVADAEKRLAVAREAISSAEENLRVEQLKYETGVGTTRDVIDAQTALLRATTDRHQASYDLAAAKAALDKALGSNAYGEVASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q63</accession>
    <name>Q39Q63_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514206.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3399"/>
    <dbReference type="EnsemblBacteria" id="ABB33611">
        <property type="protein sequence ID" value="ABB33611"/>
        <property type="gene ID" value="Gmet_3399"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3399"/>
    <dbReference type="HOGENOM" id="CLU_625237_0_0_7"/>
    <dbReference type="OMA" id="FLHIRIM"/>
    <dbReference type="OrthoDB" id="743737at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223134" evidence="1">
        <location>
            <begin position="24"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="438" mass="47709" checksum="A8DBE565AADAEC89" modified="2005-11-22" version="1">MGRLVCAVVLLAALFAATTPCRAEGGEHPFGSHQPRHTGQQEEHPLQQLLLALITRPGIPSDSHRTALLPAIHAGAEAFGDALGHRRAHRFSRDLKPLLAAYDAAISSAADGLAGAEARGATMDRLLSGIIEVAKQSKIYPEEVDTALLQAAAAVEKSLLRPPLAKVLSLEDRELVSLLLLKSVYQVHGRTVLLVEIPDALATLGVEASLAETYTKSIAWCGPALARELVALERDLSDPNILADLNNLIMMQFNAEATNDMFYAKVGLESYLAAYSFDLTPLAAKMASLGGIMAHMTPDLLRESGAVPLGLRYLAAFSWLEPLSPLVYAPDPALADRLRSLGGEVPASPDFSLFTSPYRDIFQLRYDLTLCELIMIREWWDAADQAFVLRQRPLSMTERLALRKADAERRQTVMGRLAGVTENEKHALRILMSGFFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q75</accession>
    <name>Q39Q75_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Ribosomal RNA small subunit methyltransferase E</fullName>
            <ecNumber evidence="4 10">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rsmE</name>
        <name evidence="11" type="ordered locus">Gmet_3387</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>S-adenosyl-L-methionine + uridine(1498) in 16S rRNA = H(+) + N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="4 10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512613.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3387"/>
    <dbReference type="EnsemblBacteria" id="ABB33599">
        <property type="protein sequence ID" value="ABB33599"/>
        <property type="gene ID" value="Gmet_3387"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3387"/>
    <dbReference type="eggNOG" id="COG1385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067442_3_0_7"/>
    <dbReference type="OMA" id="TQWKGER"/>
    <dbReference type="OrthoDB" id="1490892at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="rRNA_ssu_MeTrfase-E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="PTHR30027"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015601">
        <property type="entry name" value="MTase_slr0722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00046">
        <property type="entry name" value="TIGR00046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR015601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="263" mass="28795" checksum="F7F9EB5987CB1A5F" modified="2005-11-22" version="1">MSVRRFMAPGADLAGESVRIEGDLFRHMVKVLRLKIDTRVRLADGHGVECAGIIQEIGRDHLTVAVEERHAVAPVGGSLRITLIQGLPKGEKMELILQKGTELGVNEVVPFQADRSVSRIPADRQDERLRRWQRIAAEAARQAGRLDIPTVQLAQGMDEAVRDTDHDLKLLLWEEERATTLQGAINVRPRPASIAVIVGPEGGLTREEAETARRTGFIPVTLGRRILRTETAGIALLAILQYLYGDLGEGENPEEGPGSSLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q86</accession>
    <name>Q39Q86_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512602.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3376"/>
    <dbReference type="EnsemblBacteria" id="ABB33588">
        <property type="protein sequence ID" value="ABB33588"/>
        <property type="gene ID" value="Gmet_3376"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3376"/>
    <dbReference type="eggNOG" id="ENOG5030XSS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092699_0_0_7"/>
    <dbReference type="OMA" id="ADMITNA"/>
    <dbReference type="OrthoDB" id="1522364at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223256" evidence="1">
        <location>
            <begin position="26"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="219" mass="23359" checksum="E82A791893442405" modified="2005-11-22" version="1">MKKILLILLAMAVTALAPMGTTAYAAEHSHAVRDKGATTVTARADLQAGLRDLWIGHVFWVRNVALTTKYGDSTAAAIAEGKVVENAKAIAASIEPFYGKPASDKLFGLLAGHYGAVKAYMTASYAGDKAGKEAAKDKLVKNADEIAAFLSGANPYLPRETLKTLLYAHGGHHMAQLDALAGKDFAQEAKVWDDMKDHMYVIADALAGGLAKQFPKMIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q94</accession>
    <name>Q39Q94_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type II secretion system minor pseudopilin GspH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gspH</name>
        <name evidence="1" type="ordered locus">Gmet_3368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366184.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3368"/>
    <dbReference type="EnsemblBacteria" id="ABB33580">
        <property type="protein sequence ID" value="ABB33580"/>
        <property type="gene ID" value="Gmet_3368"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3368"/>
    <dbReference type="eggNOG" id="COG4970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118067_0_0_7"/>
    <dbReference type="OMA" id="MTVMAYP"/>
    <dbReference type="OrthoDB" id="1964089at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="178" mass="18993" checksum="7A58B7B2630CFE85" modified="2005-11-22" version="1">MPTSRAGTSSNRRPSCRGFTLMELLVVIALLGLMAAIALPRLTVSHALELNRSARQLAATIRYVQDRAITGKTPHRIRLEPGTGTVRVTRLLSDGTEGSTGESFLDRPLPAEGVTVADVTTPRGGKVTTGEVVLRFDMAGLGDFTAIHLRGEDDAAMTVMAYPSGKVTVSEGYVEEPQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-26" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QA8</accession>
    <name>NUOB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit B</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoB</name>
        <name type="ordered locus">Gmet_3354</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512580.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QA8"/>
    <dbReference type="SMR" id="Q39QA8"/>
    <dbReference type="STRING" id="269799.Gmet_3354"/>
    <dbReference type="EnsemblBacteria" id="ABB33566">
        <property type="protein sequence ID" value="ABB33566"/>
        <property type="gene ID" value="Gmet_3354"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3354"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_7_3_7"/>
    <dbReference type="OMA" id="GPYWEHG"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000376240" description="NADH-quinone oxidoreductase subunit B">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01356"/>
        </source>
    </evidence>
    <sequence length="170" mass="18290" checksum="64719D1CAA34B8D6" modified="2005-11-22" version="1">MGVDQPLGDSFITASLDGLVNWARKSSIWPMTFGLACCAIEMMATGASHNDLDRFGIIFRASPRQADCIIIAGTVTKKMLPVIQTVYEQMPEPKWVVAMGACACSGGVFDTYSVVQGIDEALPVDVYIPGCPPRPEALLYGLIKLQDKIMKDKNSFGSTIGLGQRLESAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QF5</accession>
    <name>Q39QF5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Short-chain acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_3306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512530.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3306"/>
    <dbReference type="EnsemblBacteria" id="ABB33519">
        <property type="protein sequence ID" value="ABB33519"/>
        <property type="gene ID" value="Gmet_3306"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3306"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_7"/>
    <dbReference type="OMA" id="AMEELFW"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="BRENDA" id="1.3.8.10">
        <property type="organism ID" value="2414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="228"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="380" mass="40990" checksum="2E3B97EB1A1E4CE4" modified="2005-11-22" version="1">MKHLTEEQKLTLDMVRDVATREIAPRALELDEKSLFPEYARDLFAKLGLLNPLLPAAYGGTEMGVLTLALILEELGRVCASTALLLIAQTDGMLPIIHGGSPELKERYLRRFAGESTLLTALAATEPAAGSDLLAMKTRAVRQGDKYVINGQKCFITNGSVADVIVVYAYTDPEKGSKGISAFVVEKGTPGLVYGRNESKMGMRGSINSELFFENMEVPAENIIGAEGTGFANLMQTLSTNRVFCAAQAVGIAQGALDIAVRHTQDRVQFGKPIAHLAPVQFMVADMATAVEASRLLTRKAAELLDDGDKKAVLYGSMAKTMASDTAMRVTTDAVQVLGGSGYMKENGVERMMRDAKLTQIYTGTNQITRMVTGRALLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QG7</accession>
    <name>Q39QG7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl:benzoate coenzyme A transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3294</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512518.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3294"/>
    <dbReference type="EnsemblBacteria" id="ABB33507">
        <property type="protein sequence ID" value="ABB33507"/>
        <property type="gene ID" value="Gmet_3294"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3294"/>
    <dbReference type="eggNOG" id="COG0427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030703_1_0_7"/>
    <dbReference type="OrthoDB" id="319106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="278"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="437" mass="47933" checksum="85FB810D0C7C2B1C" modified="2005-11-22" version="1">MNNAALAVSRYEQEYQQKLSTAEEVAATVKSGDHLCFPICAGEPTLFVKALAARKHELERVVVNQQHHLCPDYLTEESTPHIRVNSWFTSHVSRKAVQNGWADFVPNYFHEVPKLLREYWPVDIAGTVVSPMDEHGFFTCSLSVAYTMEAVKKANRVVVQVNPNAPRTHGNCHIHISDVDFIIETNDPIVELAIPPITPIEEAIGGYIAELIEDGSTLQLGIGGIPNAVCKALLKKRDLGIHTEMITDGMVDLMFSGAVNNSKKNLLPGKTLGTFALGTKRLYEFMNENPMIEMHPVDFTNNPYNIGQNDKVVAINATIEVDLLGQCCSESLGHVQWSGTGGQADFVRGANISRGGKSFITTAATAKNGTVSSIVPTLKPGAAVTTNKNDVDYVVTEFGVAKLRGQTARQRALNLINIAHPDFREELTAEARRMNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QX1</accession>
    <name>Q39QX1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Site-specific DNA-methyltransferase (adenine-specific)</fullName>
            <ecNumber evidence="3 7">2.1.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_3140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:15197"/>
            <dbReference type="Rhea" id="RHEA-COMP:12418"/>
            <dbReference type="Rhea" id="RHEA-COMP:12419"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90615"/>
            <dbReference type="ChEBI" id="CHEBI:90616"/>
            <dbReference type="EC" id="2.1.1.72"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.72" evidence="3 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514315.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3140"/>
    <dbReference type="REBASE" id="11550">
        <property type="entry name" value="M.GmeI"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33353">
        <property type="protein sequence ID" value="ABB33353"/>
        <property type="gene ID" value="Gmet_3140"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3140"/>
    <dbReference type="eggNOG" id="COG0338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_439881_0_0_7"/>
    <dbReference type="OMA" id="HELGCYV"/>
    <dbReference type="OrthoDB" id="1206955at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1020.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012186">
        <property type="entry name" value="Ade-mod_methylase_MStsI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023095">
        <property type="entry name" value="Ade_MeTrfase_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012327">
        <property type="entry name" value="MeTrfase_D12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30481">
        <property type="entry name" value="PTHR30481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02086">
        <property type="entry name" value="MethyltransfD12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036638">
        <property type="entry name" value="M_m6A_StsI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00505">
        <property type="entry name" value="D12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00571">
        <property type="entry name" value="dam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="638" mass="72657" checksum="9B18C2555DD4BF12" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QZ6</accession>
    <name>Q39QZ6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Flagellar basal-body rod protein FlgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">flgC</name>
        <name evidence="9" type="ordered locus">Gmet_3114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5 6">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514289.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3114"/>
    <dbReference type="EnsemblBacteria" id="ABB33328">
        <property type="protein sequence ID" value="ABB33328"/>
        <property type="gene ID" value="Gmet_3114"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3114"/>
    <dbReference type="eggNOG" id="COG1558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123272_0_0_7"/>
    <dbReference type="OMA" id="YVAYPNI"/>
    <dbReference type="OrthoDB" id="1870921at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006299">
        <property type="entry name" value="FlgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01395">
        <property type="entry name" value="FlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="7">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="8">
        <location>
            <begin position="95"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="15809" checksum="74677AF3318B6815" modified="2005-11-22" version="1">MDFFSAMQISSSALSAERTRMNLISSNIANANSTRTAEGGPYKRKDAVFAATPAAEKFQAAMERMRRGTSPAGVQVTQVIEDQNPPRLQYDPTHPDANAQGYVALPNVNVVEEMADMIAATRAYEANVTAVQAAKGMALKTLELGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QZ8</accession>
    <name>Q39QZ8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Flagellar M-ring protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">fliF</name>
        <name evidence="14" type="ordered locus">Gmet_3112</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The M ring may be actively involved in energy transduction.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the FliF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366144.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3112"/>
    <dbReference type="EnsemblBacteria" id="ABB33326">
        <property type="protein sequence ID" value="ABB33326"/>
        <property type="gene ID" value="Gmet_3112"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3112"/>
    <dbReference type="eggNOG" id="COG1766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028108_1_1_7"/>
    <dbReference type="OMA" id="NYEVNRI"/>
    <dbReference type="OrthoDB" id="167675at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009431">
        <property type="term" value="C:bacterial-type flagellum basal body, MS ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013556">
        <property type="entry name" value="Flag_M-ring_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000067">
        <property type="entry name" value="FlgMring_FliF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006182">
        <property type="entry name" value="FliF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043427">
        <property type="entry name" value="YscJ/FliF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046">
        <property type="entry name" value="PTHR30046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30046:SF0">
        <property type="entry name" value="PTHR30046:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01514">
        <property type="entry name" value="YscJ_FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08345">
        <property type="entry name" value="YscJ_FliF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004862">
        <property type="entry name" value="FliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01009">
        <property type="entry name" value="FLGMRINGFLIF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00206">
        <property type="entry name" value="fliF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF" evidence="12">
        <location>
            <begin position="42"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="YscJ_FliF_C" evidence="13">
        <location>
            <begin position="250"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="283"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB33326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="527" mass="57314" checksum="33FBAAFBCED42C6B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R48</accession>
    <name>Q39R48_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2220 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513621.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3061"/>
    <dbReference type="EnsemblBacteria" id="ABB33276">
        <property type="protein sequence ID" value="ABB33276"/>
        <property type="gene ID" value="Gmet_3061"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3061"/>
    <dbReference type="eggNOG" id="COG1697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054915_1_0_7"/>
    <dbReference type="OMA" id="YHWGDID"/>
    <dbReference type="OrthoDB" id="1197364at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024534">
        <property type="entry name" value="DUF2220"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09983">
        <property type="entry name" value="DUF2220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="SSF56726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2220" evidence="1">
        <location>
            <begin position="255"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="401" mass="44115" checksum="42843C5C93E36FD0" modified="2005-11-22" version="1">MNQSSRQLLRKLLDAWQANPDRSRLVRLPITQARAPQYFEASLPEAKEAIHAGLLEAASAGTVALEWGRGYESHILKRITLTDGPGLANYLGMPLAAKQADDARSILETALSGRETWINEWVEDLLGKWSRNQSAAGMSPGDTASARLMVRALEAVVAGRHLNLDLRTFSTREFGDSKAMEGMLARFTSVWKKYHPTELTGEELLETLGLVRFPPPLLLSGPVVLKLSDRHLDCEGIRPFVGLPPQAIRGVSADKLPEYVLTVENLASFNRYAAEIRDNGLVLYTAGFPSPGLADFLRMLDVSLPSGMPFFHWGDIDEGGLKIFVYVQGLLRRTLQPHLMTVDLLASCGLPKPSLRVDEVKRTAEKYPAIALLAAAIISTDPPKTLEQENVNPFTPAVETQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R53</accession>
    <name>Q39R53_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integration host factor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ihfA-4</name>
        <name evidence="9" type="ordered locus">Gmet_3056</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33271.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3056"/>
    <dbReference type="EnsemblBacteria" id="ABB33271">
        <property type="protein sequence ID" value="ABB33271"/>
        <property type="gene ID" value="Gmet_3056"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3056"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3431861_0_0_7"/>
    <dbReference type="OMA" id="FDMISEY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13835">
        <property type="entry name" value="IHF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005684">
        <property type="entry name" value="IHF_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33271.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="93" mass="10586" checksum="A405ED954C25D556" modified="2012-10-31" version="2">MTKEEIAELVSTKGAIQRREADEMVEVLLEQIKKTLEREDRIKITGFGNFEVKRKADRRGRNPQTGEALTIQSRRVLTFKPSAVLKNSINGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R84</accession>
    <name>Q39R84_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514339.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3025"/>
    <dbReference type="EnsemblBacteria" id="ABB33240">
        <property type="protein sequence ID" value="ABB33240"/>
        <property type="gene ID" value="Gmet_3025"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3025"/>
    <dbReference type="eggNOG" id="COG1315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026157_0_1_7"/>
    <dbReference type="OMA" id="TGHVKFK"/>
    <dbReference type="OrthoDB" id="379544at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005646">
        <property type="entry name" value="FapA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38032">
        <property type="entry name" value="PTHR38032"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03961">
        <property type="entry name" value="FapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="432"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="546" mass="58354" checksum="C668BF368CCABE5B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R86</accession>
    <name>Q39R86_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADPH oxidoreductase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sfrB</name>
        <name evidence="6" type="ordered locus">Gmet_3023</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514337.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3023"/>
    <dbReference type="EnsemblBacteria" id="ABB33238">
        <property type="protein sequence ID" value="ABB33238"/>
        <property type="gene ID" value="Gmet_3023"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3023"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_4_7"/>
    <dbReference type="OMA" id="MGRVCPA"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="5">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="672" mass="73748" checksum="421650105D95B02B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R92</accession>
    <name>Q39R92_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF190 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0166 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514331.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3017"/>
    <dbReference type="EnsemblBacteria" id="ABB33232">
        <property type="protein sequence ID" value="ABB33232"/>
        <property type="gene ID" value="Gmet_3017"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3017"/>
    <dbReference type="eggNOG" id="COG1993">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_146749_0_1_7"/>
    <dbReference type="OMA" id="EHWNTLR"/>
    <dbReference type="OrthoDB" id="1984529at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003793">
        <property type="entry name" value="DUF190"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02641">
        <property type="entry name" value="DUF190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF190" evidence="2">
        <location>
            <begin position="10"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="114" mass="12763" checksum="FF0ED474BF06EA24" modified="2005-11-22" version="1">MTKLIGEQVLMRIFIGEGDKHGRKPLHEALVELFRQEGFAGATVLRGVAGFGARSVYHTDKLLRLSADLPLVVEVVDSQERFDAIMPKIDAMMSGGMITLEKATVIHYDHRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RC5</accession>
    <name>Q39RC5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514475.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2984"/>
    <dbReference type="EnsemblBacteria" id="ABB33199">
        <property type="protein sequence ID" value="ABB33199"/>
        <property type="gene ID" value="Gmet_2984"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2984"/>
    <dbReference type="eggNOG" id="ENOG503380W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_202968_0_0_7"/>
    <dbReference type="OMA" id="GMQFAMR"/>
    <dbReference type="OrthoDB" id="2037147at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025234">
        <property type="entry name" value="DUF4177"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13783">
        <property type="entry name" value="DUF4177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="61" mass="7226" checksum="4ED64DDA24B3D28D" modified="2005-11-22" version="1">MPIYKVVEINTVTEDVLEEILNEWTAKGWRFDGMQFAMRDASRRPAMAFVFFTREEREVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RD0</accession>
    <name>Q39RD0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514470.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2979"/>
    <dbReference type="EnsemblBacteria" id="ABB33194">
        <property type="protein sequence ID" value="ABB33194"/>
        <property type="gene ID" value="Gmet_2979"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2979"/>
    <dbReference type="HOGENOM" id="CLU_154476_0_0_7"/>
    <dbReference type="OMA" id="CATEEYV"/>
    <dbReference type="OrthoDB" id="2085844at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="137" mass="14262" checksum="869277D9299755D0" modified="2005-11-22" version="1">MKRIVTAAVIPFLALTAGCATKTFVQEQTAPLADRISGLEKRLNTIEAQVADLSKRPVATPADLDAVKRENADIRTQAQQSAQNAQQSAEAAAAAATRAETAATKADAAATKAEGAARQAEQSAGKSAKAFELQQKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RK1</accession>
    <name>PUR9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional purine biosynthesis protein PurH</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Phosphoribosylaminoimidazolecarboxamide formyltransferase</fullName>
                <ecNumber evidence="1">2.1.2.3</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">AICAR transformylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">IMP cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.10</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">ATIC</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">IMP synthase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">Inosinicase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">purH</name>
        <name type="ordered locus">Gmet_2905</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide = (6S)-5,6,7,8-tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:22192"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="2.1.2.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + IMP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:18445"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:58467"/>
            <dbReference type="EC" id="3.5.4.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The IMP cyclohydrolase activity resides in the N-terminal region.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PurH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.3" evidence="1"/>
    <dbReference type="EC" id="3.5.4.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512841.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RK1"/>
    <dbReference type="SMR" id="Q39RK1"/>
    <dbReference type="STRING" id="269799.Gmet_2905"/>
    <dbReference type="EnsemblBacteria" id="ABB33123">
        <property type="protein sequence ID" value="ABB33123"/>
        <property type="gene ID" value="Gmet_2905"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2905"/>
    <dbReference type="eggNOG" id="COG0138">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016316_5_2_7"/>
    <dbReference type="OMA" id="WRVAKFV"/>
    <dbReference type="OrthoDB" id="1049662at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00133"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00135"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003937">
        <property type="term" value="F:IMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004643">
        <property type="term" value="F:phosphoribosylaminoimidazolecarboxamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00139">
        <property type="entry name" value="PurH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024051">
        <property type="entry name" value="AICAR_Tfase_dup_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002695">
        <property type="entry name" value="PurH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11692">
        <property type="entry name" value="PTHR11692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01808">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000414">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00798">
        <property type="entry name" value="AICARFT_IMPCHas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00355">
        <property type="entry name" value="purH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000057896" description="Bifunctional purine biosynthesis protein PurH">
        <location>
            <begin position="1"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01202"/>
        </source>
    </evidence>
    <sequence length="521" mass="55783" checksum="4545BC83ABDCD382" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RQ5</accession>
    <name>Q39RQ5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Chaperone protein ClpB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 13" type="primary">clpB</name>
        <name evidence="13" type="ordered locus">Gmet_2851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homohexamer; The oligomerization is ATP-dependent.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514565.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2851"/>
    <dbReference type="EnsemblBacteria" id="ABB33069">
        <property type="protein sequence ID" value="ABB33069"/>
        <property type="gene ID" value="Gmet_2851"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2851"/>
    <dbReference type="eggNOG" id="COG0542">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005070_4_1_7"/>
    <dbReference type="OMA" id="ERMKAVM"/>
    <dbReference type="OrthoDB" id="44062at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017730">
        <property type="entry name" value="Chaperonin_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="SSF81923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03346">
        <property type="entry name" value="chaperone_ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Clp R" evidence="12">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="414"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB33069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="864" mass="96246" checksum="F8A3714349D3411B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RS8</accession>
    <name>Q39RS8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Methyl-accepting chemotaxis sensory transducer, class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mcp40H-13</name>
        <name evidence="9" type="ordered locus">Gmet_2828</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366108.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2828"/>
    <dbReference type="EnsemblBacteria" id="ABB33046">
        <property type="protein sequence ID" value="ABB33046"/>
        <property type="gene ID" value="Gmet_2828"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2828"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_7"/>
    <dbReference type="OMA" id="THAISEN"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003122">
        <property type="entry name" value="Tar_rcpt_lig-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02203">
        <property type="entry name" value="TarH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="220"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="7">
        <location>
            <begin position="277"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="550" mass="58485" checksum="4F0BC66F0516B3B4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S48</accession>
    <name>Q39S48_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Scaffold protein CheW associated with MCPs of class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheW40H-5</name>
        <name evidence="2" type="ordered locus">Gmet_2708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511752.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2708"/>
    <dbReference type="EnsemblBacteria" id="ABB32926">
        <property type="protein sequence ID" value="ABB32926"/>
        <property type="gene ID" value="Gmet_2708"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2708"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_4_0_7"/>
    <dbReference type="OMA" id="SNGSMEF"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="62"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="205" mass="22791" checksum="95D6CCC571EC5E38" modified="2005-11-22" version="1">MTHTPFAKSGKAIDWDDIHQRLEAARKALSQELSPDEEKRILKTRAAALAREPLSGETTEGHLEILEFLLAYERYGIEMSWVRETCPLKDLTPIPCTPPFVLGLINVRGEIISVIDLKKFFDLPEKGLTDLNKVVIVHGGDMTFGILADEILGVRPVPGDAIQPTLPTLTGIREEYLKGITGERAIILDGSRILNDRRIIVNDEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SA1</accession>
    <name>Q39SA1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2655</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511806.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2655"/>
    <dbReference type="EnsemblBacteria" id="ABB32873">
        <property type="protein sequence ID" value="ABB32873"/>
        <property type="gene ID" value="Gmet_2655"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2655"/>
    <dbReference type="HOGENOM" id="CLU_784723_0_0_7"/>
    <dbReference type="OrthoDB" id="2226396at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223471" evidence="3">
        <location>
            <begin position="30"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="353" mass="38581" checksum="AA76532113ECB1ED" modified="2005-11-22" version="1">MLRLGSLLRLTPVVLLLLSAAAGPQTALAGFEVDCKASARAYADQGIPCYCRGGRIECDQPSGGGSYGSSPKSGLSFKNQMKLQIMQSITDMAANAFINWLNGPSPSQQSGPTPQQIAEQKAAQERAAAEWRAKVEQQIREMESQYEQQKKQEFTDKKKKLLAGIRGLDASSPGRDSHAFRQLRCSAYWGGQVARALAAGDEKRAEEYRKFSEKPTGESMARCDKEFPEPPMPDGAVEVRMGLYQTMIEEVHLRLPMIEQAKEKQRNATEQVAEKQKKVEELKSQATTLPPAEKEVADDLLAQALKELDTATTLKNEADAGVKKLELEIDALNEVGKLATAPKAGQTTKGSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SB4</accession>
    <name>Q39SB4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein glutamate methyltransferase CheR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheR-7</name>
        <name evidence="2" type="ordered locus">Gmet_2641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511820.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2641"/>
    <dbReference type="DNASU" id="3740219"/>
    <dbReference type="EnsemblBacteria" id="ABB32860">
        <property type="protein sequence ID" value="ABB32860"/>
        <property type="gene ID" value="Gmet_2641"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2641"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_1_0_7"/>
    <dbReference type="OMA" id="DYYTAAY"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="280" mass="32333" checksum="896AC4DCB5505CBD" modified="2005-11-22" version="1">MEPDELFDIEMRLLLHGVRQVYGHDFTDYSEASIKRRITQWFATSGYGTLSEAQAAILRNREAFDSLLRGITVNVSEMFRDPAFFRALREEIVPHLKTYPFVKIWHAGCSSGEEAYSLAILLEEEGMKGRFRMYATDINNEVLQNAREGIFPLKEMQKYTRNYQAAGGKGAFSDYYLARYEHAIMIQSLRDQIVFASHNLAVDADFGEMHLILCRNVLIYFKPTLKERVLRLFDTCLIPGGFLCLGLKESLDGRRIASRYAETVERMRIYRKSYGQEQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SN0</accession>
    <name>Q39SN0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic diguanosine monophosphate-binding protein</fullName>
            <shortName evidence="1">c-di-GMP-binding protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pilz domain-containing protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2523</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second-messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer in both c-di-GMP-bound and free forms.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514528.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2523"/>
    <dbReference type="EnsemblBacteria" id="ABB32744">
        <property type="protein sequence ID" value="ABB32744"/>
        <property type="gene ID" value="Gmet_2523"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2523"/>
    <dbReference type="HOGENOM" id="CLU_146776_0_0_7"/>
    <dbReference type="OMA" id="LGFVCRH"/>
    <dbReference type="OrthoDB" id="2003700at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027021">
        <property type="entry name" value="C-di-GMP_BP_PA4608"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028141">
        <property type="entry name" value="C-di-GMP_BP_PA4608"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0973">c-di-GMP</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="2">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR028141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="122" mass="13821" checksum="BA221931BF1A0F42" modified="2005-11-22" version="1">MDVTEQRHFQRVPFTTESTIEFGGKQHGAEVVDICLKGALLKLSGPPQCRRGDACTVSFVLVNSDIVVHFEAEVAHLRDQFLGVKLLKIDIDSMIHLRNIVELNTADPDQVRKELSFLYREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SS5</accession>
    <name>Q39SS5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LPS-assembly protein LptD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 4" type="primary">lptD</name>
        <name evidence="4" type="ordered locus">Gmet_2474</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the lipopolysaccharide transport and assembly complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LptD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512425.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2474"/>
    <dbReference type="EnsemblBacteria" id="ABB32699">
        <property type="protein sequence ID" value="ABB32699"/>
        <property type="gene ID" value="Gmet_2474"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2474"/>
    <dbReference type="eggNOG" id="COG1452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009039_4_0_7"/>
    <dbReference type="OMA" id="YDRMPQI"/>
    <dbReference type="OrthoDB" id="100018at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015920">
        <property type="term" value="P:lipopolysaccharide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010033">
        <property type="term" value="P:response to organic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01411">
        <property type="entry name" value="LPS_assembly_LptD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020889">
        <property type="entry name" value="LipoPS_assembly_LptD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007543">
        <property type="entry name" value="LptD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005653">
        <property type="entry name" value="OstA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04453">
        <property type="entry name" value="LptD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13100">
        <property type="entry name" value="OstA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019134" description="LPS-assembly protein LptD" evidence="1">
        <location>
            <begin position="26"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="OstA-like_N" evidence="3">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="LptD" evidence="2">
        <location>
            <begin position="272"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="697" mass="78899" checksum="5881D30ECDDD5FFE" modified="2005-11-22" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SU6</accession>
    <name>Q39SU6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2453</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512447.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2453"/>
    <dbReference type="EnsemblBacteria" id="ABB32678">
        <property type="protein sequence ID" value="ABB32678"/>
        <property type="gene ID" value="Gmet_2453"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2453"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="FHKNGAD"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="10"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="149"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="461" mass="51783" checksum="FF7BFEB6CAE6078C" modified="2005-11-22" version="1">MANGEKKTVRVLIVDDDVSLRRVLEYNLQEEGYEVLTAGSGEEGLRLFEDGAPTLVVTDLKMPGMGGFQLLREVKERFPDTVVIVITAFGAVEAAVEAMKAGAYDFITKPFNREALKLTVRKALDMQGLSRENRRLREELSEREEFRSIIGISPPMEEVFRVIDRVADTDATVLITGESGTGKELVARAIHNRSSRRAAPFVAINCAAIPRDLLESELFGHVKGAFTGAVQDKEGKFRQAEAGTLFLDEVGELPVELQSKLLRALQEKEVQPVGGAHTIKLDVRVVAATNADLEEAIAEGRFREDLFYRLSVIPVHLPPLRERKEDIPLLVRHFAAKHGGASVTFSPEILAVMAAYGWPGNVRELENTVERILIMRNADTIHPDDLPEKVRRGRSPQRECRVINLPDEGYSLEQLEREIVVEALERNNWNQSSAARFLRIPRHTLIYRMEKYSITTPERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SZ5</accession>
    <name>Q39SZ5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoenolpyruvate--protein phosphotransferase</fullName>
            <ecNumber evidence="5">2.7.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">ptsP</name>
        <name evidence="13" type="ordered locus">Gmet_2404</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366048.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2404"/>
    <dbReference type="EnsemblBacteria" id="ABB32629">
        <property type="protein sequence ID" value="ABB32629"/>
        <property type="gene ID" value="Gmet_2404"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2404"/>
    <dbReference type="eggNOG" id="COG3605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_7_1_7"/>
    <dbReference type="OMA" id="MFPMISE"/>
    <dbReference type="OrthoDB" id="467393at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAF" evidence="12">
        <location>
            <begin position="26"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="165"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="784" mass="86988" checksum="AE607A7FCC9DBF60" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SZ8</accession>
    <name>Q39SZ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin domain protein YyaL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yyaL</name>
        <name evidence="2" type="ordered locus">Gmet_2401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512499.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2401"/>
    <dbReference type="EnsemblBacteria" id="ABB32626">
        <property type="protein sequence ID" value="ABB32626"/>
        <property type="gene ID" value="Gmet_2401"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2401"/>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014051_4_2_7"/>
    <dbReference type="OMA" id="PFYFGTY"/>
    <dbReference type="OrthoDB" id="854580at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02955">
        <property type="entry name" value="SSP411"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004879">
        <property type="entry name" value="DUF255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024705">
        <property type="entry name" value="Ssp411"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42899">
        <property type="entry name" value="PTHR42899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03190">
        <property type="entry name" value="Thioredox_DsbH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006402">
        <property type="entry name" value="UCP006402_thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="SSF48208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredox_DsbH" evidence="1">
        <location>
            <begin position="33"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="706" mass="77818" checksum="234AFAAA83E6B0ED" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T02</accession>
    <name>Q39T02_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Succinate dehydrogenase/fumarate reductase, cytochrome b558 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">frdC</name>
        <name evidence="8" type="ordered locus">Gmet_2397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366047.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2397"/>
    <dbReference type="EnsemblBacteria" id="ABB32622">
        <property type="protein sequence ID" value="ABB32622"/>
        <property type="gene ID" value="Gmet_2397"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2397"/>
    <dbReference type="eggNOG" id="ENOG502Z7RU">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077968_0_0_7"/>
    <dbReference type="OMA" id="LHFYDFW"/>
    <dbReference type="OrthoDB" id="750409at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011138">
        <property type="entry name" value="Cytochrome_b-558"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="SSF81343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02046">
        <property type="entry name" value="sdhC_b558_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="220" mass="24030" checksum="5CEDD93925C7E309" modified="2005-11-22" version="1">MQLFTSTVGRKVLMAITGQFLVLFIIVHLLGNSSIFIPGGINAYAEHLHALPPLVWGFRLVILCVAIIHIFFGVQLSLENRAANPDTYAVKNLKEATLSSTSMLYTGLLLLAFILYHLLQFTVRATPDIKVGVDALGRVDVFGMVTNSFSHGIIAVLYIAAMVVLFLHLSHGIQSFFQTMGWNNHKSRPVFSTIGKVAAVVFLLGYASIPFVIVTGILKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T11</accession>
    <name>Q39T11_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenosine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514770.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2388"/>
    <dbReference type="EnsemblBacteria" id="ABB32613">
        <property type="protein sequence ID" value="ABB32613"/>
        <property type="gene ID" value="Gmet_2388"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2388"/>
    <dbReference type="eggNOG" id="COG1839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138382_0_0_7"/>
    <dbReference type="OMA" id="FGIAFCE"/>
    <dbReference type="OrthoDB" id="1392364at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007153">
        <property type="entry name" value="Adenosine_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036902">
        <property type="entry name" value="Ta1353-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36155">
        <property type="entry name" value="PTHR36155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04008">
        <property type="entry name" value="Adenosine_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103165">
        <property type="entry name" value="SSF103165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="162" mass="17599" checksum="60F5949B76D8067B" modified="2005-11-22" version="1">MSLEINAIAIDIPDDCNLILGQTHFIKTAEDLYEIIATTVSLARFGIAFTEASGPCLIRTEGNDDELTQACVRNLQAIGAGHVFCILLRDAYPINILNQIKNCPEVCSIYCATANPLQVIVASTAQGSGVLGVIDGFPPKGVESDDDRQKRRDFLRAIGYKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T75</accession>
    <name>Q39T75_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endoribonuclease L-PSP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RutC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513296.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2324"/>
    <dbReference type="EnsemblBacteria" id="ABB32549">
        <property type="protein sequence ID" value="ABB32549"/>
        <property type="gene ID" value="Gmet_2324"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2324"/>
    <dbReference type="eggNOG" id="COG0251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100715_7_3_7"/>
    <dbReference type="OMA" id="GSYFKEP"/>
    <dbReference type="OrthoDB" id="1850770at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006056">
        <property type="entry name" value="RidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019897">
        <property type="entry name" value="RidA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="PTHR11803"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="SSF55298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00004">
        <property type="entry name" value="TIGR00004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01094">
        <property type="entry name" value="UPF0076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="125" mass="13107" checksum="77263059914ED82E" modified="2005-11-22" version="1">MKEIIATDKAPKAIGPYSQAVKAGGFLFLSGQIPLDPATGEFVPGGIREQTDRVMDNIAAVLAEAGLGFDAVVKTTIFLTDLANFGVVNEVYGSRFSAEPPARSTVEVKGLPRGALVEIEVLALC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TC8</accession>
    <name>Q39TC8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_2270</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2270"/>
    <dbReference type="EnsemblBacteria" id="ABB32496">
        <property type="protein sequence ID" value="ABB32496"/>
        <property type="gene ID" value="Gmet_2270"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2270"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_12_2_7"/>
    <dbReference type="OMA" id="IKGASTC"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="37"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="284"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="468"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="615" mass="66740" checksum="F1316A455D6B90D8" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TM2</accession>
    <name>Q39TM2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Single-stranded right-handed parallel beta-helix fold protein, galacturonase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365931.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2173"/>
    <dbReference type="EnsemblBacteria" id="ABB32402">
        <property type="protein sequence ID" value="ABB32402"/>
        <property type="gene ID" value="Gmet_2173"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2173"/>
    <dbReference type="eggNOG" id="COG5434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_381191_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223112" evidence="1">
        <location>
            <begin position="26"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="193"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="726" mass="76865" checksum="A6B1E4D901BAF1A1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TR6</accession>
    <name>Q39TR6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pcmM</name>
        <name evidence="1" type="ordered locus">Gmet_2129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513076.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2129"/>
    <dbReference type="EnsemblBacteria" id="ABB32358">
        <property type="protein sequence ID" value="ABB32358"/>
        <property type="gene ID" value="Gmet_2129"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2129"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="NTLMPGP"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="255" mass="26818" checksum="57210E80FF0E88A4" modified="2005-11-22" version="1">MGKLTGKVAIITGGAQGIGAAYAVGLAKEGAKIVIADVLDGAKAVEAVKAAGSDAIYVKTDVSSQEQCDAMAQAAAEKFGSVDILLNNAAIFGSIVLKPFTECTPQEFMKVMEINVLGQFNCMKAVFPHMKARGGKIINISSSSIIEGVPGMPHYVASKGAIMALTRSMARELGDYKINVNTIAPGFTHSDGGNSFDKNKKLDLPPLEELQINARCLKREAVPEDLIGLALFLSSDDSAFITGQMIVHDGGLSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TU2</accession>
    <name>Q39TU2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0261 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365918.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2103"/>
    <dbReference type="DNASU" id="3739554"/>
    <dbReference type="EnsemblBacteria" id="ABB32332">
        <property type="protein sequence ID" value="ABB32332"/>
        <property type="gene ID" value="Gmet_2103"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2103"/>
    <dbReference type="eggNOG" id="COG5441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036813_1_0_7"/>
    <dbReference type="OMA" id="NFWAPST"/>
    <dbReference type="OrthoDB" id="824620at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008322">
        <property type="entry name" value="UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033271">
        <property type="entry name" value="UCP033271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="1">
        <location>
            <begin position="6"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="418" mass="45478" checksum="99294E320E7A3961" modified="2005-11-22" version="1">MAQKKGIVIICNLDTRGEDIIFVKQLIETRGHNAYFLDFSMEEPPPFAGDITCEHVAERGGMTIEAVRECYRSDRDRAMENQIRGASAIVADMMKEGKIQGVFGVGGGTSSLVGTSVMKGVPFGIPKLMASPMAAHPSYVGKYVGTHDITMHHTVLDVVKMNPLLKAQITNAVGAICGMVEMTQGTNITFDKPCVAISSFGFGEMAVQTALGMLDEAGFTPIVCHAQGKGDKAMEDMIRAGAFHGVLDICTGGIVENLFKGNRDPGPDRFMAAVETGIPMVLAPCGLDILSYGGRPDMLEKTKDRPQYVQDSLRVQVRTTADELRQAADVIAERLNRANGEWTFLIPLKGWSSQDLEGRIIYDPAADAAFVARLKEKLDEPERVKEVDLHLYTKEFARVAVDEFVRLYEGTPAQAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U19</accession>
    <name>Q39U19_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512924.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2026"/>
    <dbReference type="EnsemblBacteria" id="ABB32255">
        <property type="protein sequence ID" value="ABB32255"/>
        <property type="gene ID" value="Gmet_2026"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2026"/>
    <dbReference type="eggNOG" id="COG3267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024125_0_0_7"/>
    <dbReference type="OMA" id="YHLGPLD"/>
    <dbReference type="OrthoDB" id="947558at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017466">
        <property type="entry name" value="ATPase_secr-sys_PEP-CTERM_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03015">
        <property type="entry name" value="pepcterm_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="42"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="385" mass="43620" checksum="A8960142E2540442" modified="2005-11-22" version="1">MYEEFFGFTTKPFELVPDPEFLYLSRVHKKAITYLEYGIRERNGFLLITGEIGSGKTTIIRNILKSLDEQVTLSKIFNTKVTSEQLLAMINDDFGLDVAGKDKIALLRQLNEFLVDEFVAGRQPVILIDEAQNLDIDLLEEVRLLSNLETDKSKLVQIILVGQPELRRTLANDRLRQLRQRICISCHIDHLSKAEVEEYIFHRLEKAGNRTAVEFGEGAIDLIYLFSRGVPRLINIICDFLLLSAFVEEKKVICTDLVKEVIGEIESESKFWGDESVDEKPRMTAANGKALEEMSAKVTRLEATVGDGGVASSELANLSEQIMMLEKILNGTVLALQSRIDSTDANISEMRLDMEELFKLIKMVDKGGKQLPDPPKKGFWNWMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U41</accession>
    <name>Q39U41_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, WbnK-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2004"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="DNASU" id="3739876"/>
    <dbReference type="EnsemblBacteria" id="ABB32233">
        <property type="protein sequence ID" value="ABB32233"/>
        <property type="gene ID" value="Gmet_2004"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2004"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_7"/>
    <dbReference type="OMA" id="AWQLARI"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="42"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="403" mass="43630" checksum="B0066E80222D1E24" modified="2005-11-22" version="1">MRRRSRIPMGDASGQQKACDRPITVMYIIDTFLSPCGSPMQGGAEKQLGILASSLDPSRFRPLVVQLAPRGAVPLKDGKLGPARVFHFPTGKFYSPSGFGQMLRIARLAREERVDIIQTFFEKAEVMGWLARRLAGVPVWMTSRRDLGFKRKPVYDRIFRVSSRSCDGLVAVCQAAKDETVTREGFPAGKIEVIYNALEEGTLEGATSPLPSRSDLGLPAVGPLVGMVANMNFEIKGHRYFIEAADRVARKQSAVHFILVGDGALRADCERQARDLGLSERIHFLGKRGDVPAILAHLDVSVLCSTSEGLSNVIMESMAAGKPVVATCVGGNPELVQDGVTGLVVPPADSALLAAAVGALLDDPTRAQAMGTAARRVAEERFSVRAMVEAHEELYCRLWSGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U56</accession>
    <name>Q39U56_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleotide cyclase, HAMP and GGDEF-related domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1989</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365896.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1989"/>
    <dbReference type="EnsemblBacteria" id="ABB32218">
        <property type="protein sequence ID" value="ABB32218"/>
        <property type="gene ID" value="Gmet_1989"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1989"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_628158_0_0_7"/>
    <dbReference type="OMA" id="FDYDPQI"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="2">
        <location>
            <begin position="203"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="284"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="442" mass="48968" checksum="BCC084FF2C23E5A0" modified="2005-11-22" version="1">MSDSTKPLQTRTRFTLIQKLIVSYVAMLFLTTTALAFSVMGLYSLNRTAKEIAKTDLFIIDSANRLRESMLAQERIAGKYAILKSDEFKLLYSQRQSEFLAILGEIGQRDNNGLFRSLVARYDAYRKEIERAFAASTTEPLPAKKEADAVVSLIEDLSSSRQKLLGKKLAEADRREADTVKLTLFLAFSGFILAVTVAALNVHSISTSIRKLKKGMHRIAEGDFDYDPQIPIGDEIGALAEDFSRMGKKLKELEQISLDASPLTRLPGNIAIERVLNKLLQSGEPFAVCYADLDNFKAYNDRYGYIKASEVIKLTAELIHDTVRELAGGNAFVGHVGGDDFVMVVAAERGGSLCEAVIKRFDDFIRNHYSAEDLARGAIEGVDRYGVSRTFPIMSISVAVVISQQGEFTSAVQIAKAAADIKDLLKKSPGSNYLINRRRNPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U77</accession>
    <name>Q39U77_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511876.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1968"/>
    <dbReference type="EnsemblBacteria" id="ABB32197">
        <property type="protein sequence ID" value="ABB32197"/>
        <property type="gene ID" value="Gmet_1968"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1968"/>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061179_1_0_7"/>
    <dbReference type="OMA" id="LYWELIY"/>
    <dbReference type="OrthoDB" id="1808875at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="330" mass="37317" checksum="7D6506E60A741C07" modified="2005-11-22" version="1">MIRIILLLAGFLCEYTALQALFSQQQVWIRLILFIVSHLIAAVSLALLLRLSLPRQADTKKWGSLALFFSFAFFIPVLGCIGMLGALVYFRFLLRFDARPEFFSVPMTPFMQESGGPAPGMGEGGAWSRLRSESLPRPMRLKALLAAGSSNSRDASRLLHFATSDNDDEIRLLAFNLADQREKVISKTISQSLAELKNASDRDERLLHCRKLAFSYWELIFNDLAQKDLAEFYVLQSITYATQALDMDATDPNLLLLLGRLHLWREDLESAEKAINDAMNNGAHRDRVVPYLAELAFLRRDFVTMNSCFELNPLLRHKPGIGPVAQFWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U78</accession>
    <name>Q39U78_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1967</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511877.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1967"/>
    <dbReference type="EnsemblBacteria" id="ABB32196">
        <property type="protein sequence ID" value="ABB32196"/>
        <property type="gene ID" value="Gmet_1967"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1967"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046136_1_0_7"/>
    <dbReference type="OMA" id="NHYLLRI"/>
    <dbReference type="OrthoDB" id="1776821at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031583">
        <property type="entry name" value="PelD_GGDEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038367">
        <property type="entry name" value="PelD_GGDEF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16963">
        <property type="entry name" value="PelD_GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="PelD_GGDEF" evidence="2">
        <location>
            <begin position="334"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="459" mass="51025" checksum="7B192FC5542F4892" modified="2005-11-22" version="1">MAFNKDSTMILDRWLETFAITAIAVTGGFLLNSSDPLFVHARFPWVWFGPLLIALRYGIAPGLVSTGGICLALLVMPRFGLPIGEFPTNYVLGGLLMVLITGQFSDIWSKRLRHANQLSNHTSERFEQLSRAYFMVRLSHDRLEQNLISRPVTLRDAMINLRNLLAKHDGRMDSETSAALLSILMHYCSLESAAIYPANDDGELLDVPIAKCGKGAPLNRDDLLLRSAIESGYSAYQAINRHIVEGRPSAPSALSSAVWSVDVSRDESKEQTSYLVVAPMRTSSGKLLGLLLVTEMPFLNLHRETLQIMGVLLAYSSDQAESVERARDILGLFPDCPPNFAAELIKTVRLKRDLHVSSALVMVQVMADSRLDEICKTMERQQRGLDHSWLRTTDWGAQFVTLMPFSGPASIEGYKSRIHEILQRQVGRSTGQEGITMHSTSVTTDDPLVQLVALLEEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UA1</accession>
    <name>Q39UA1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32173.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365889.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1944"/>
    <dbReference type="EnsemblBacteria" id="ABB32173">
        <property type="protein sequence ID" value="ABB32173"/>
        <property type="gene ID" value="Gmet_1944"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1944"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073253_0_0_7"/>
    <dbReference type="OMA" id="VLECNHD"/>
    <dbReference type="OrthoDB" id="733552at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="11"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32173.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="256" mass="28083" checksum="B137B512A738D3DA" modified="2012-10-31" version="2">MRVCLLASGSKGNSLFVESDGTRVLIDAGLSAREIVRRLAVIEVEPADLDGLFISHEHVDHVRGVGVLARKYRLPVHVSYPTHHEVREGFGDAPVVEFESGYSFGFRDLLIDPFPITHDACDPVGFTIESKEGKVGIATDLGTATRLVADKLKRCRVLVLESNHDEEMLMGGPYPWHLKQRIKSRHGHLSNNDSAALLAEVLHPGLEGLFLAHLSEVNNDPAVAKEVAENLLVAQTTCSPRLIVGDQYRPSETLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UK5</accession>
    <name>Q39UK5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Translation elongation factor P-lysyl-lysine 2,3-aminomutase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">yjeK</name>
        <name evidence="11" type="ordered locus">Gmet_1840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512006.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1840"/>
    <dbReference type="EnsemblBacteria" id="ABB32069">
        <property type="protein sequence ID" value="ABB32069"/>
        <property type="gene ID" value="Gmet_1840"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1840"/>
    <dbReference type="eggNOG" id="COG1509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032161_0_1_7"/>
    <dbReference type="OMA" id="PIWLNTH"/>
    <dbReference type="OrthoDB" id="557227at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025895">
        <property type="entry name" value="LAM_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="PTHR30538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12544">
        <property type="entry name" value="LAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004911">
        <property type="entry name" value="DUF160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00238">
        <property type="entry name" value="TIGR00238"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="88"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004911-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR603739-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="344" mass="38721" checksum="8D40786596934A0A" modified="2005-11-22" version="1">METWRKAIADSITTPEELAELLDIDPEPLAPLVRRYPLRITRRYLGLIGKPGDAIWRQCVPDPCELDDDQLSDPLDEERLSPVPGVIHRYPDRVVWLVSNECAVYCRFCMRKRRVGCPLAGSNGRSGDDAVRYIAATPAIRDVILSGGDPLLLDDERLEAILARLRAIPHVEMIRIGTRTPVTLPERITARLCRMLKRYHPLYVNTHFNHPREITPEATKACARLADTGIPLGNQTVLLAGVNDEPAIMTLLMQRLLAIRVRPYYIHQMDLVRGTGHFRTKVTTGLDIIGALRGHTSGMATPYFVIDAAGGKGKIPLLPDAVERRGDTWLLRNYRGEIVEYQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UR7</accession>
    <name>Q39UR7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1858 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513327.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1776"/>
    <dbReference type="EnsemblBacteria" id="ABB32007">
        <property type="protein sequence ID" value="ABB32007"/>
        <property type="gene ID" value="Gmet_1776"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1776"/>
    <dbReference type="eggNOG" id="ENOG5033E1I">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180540_1_0_7"/>
    <dbReference type="OMA" id="FAAVMRM"/>
    <dbReference type="OrthoDB" id="1961381at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023883">
        <property type="entry name" value="CHP03980_redox-disulphide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39341">
        <property type="entry name" value="PTHR39341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03980">
        <property type="entry name" value="prismane_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="6"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="66" mass="7129" checksum="92E039B03AA5D989" modified="2005-11-22" version="1">MSQQFTKDMTFAQALQANPEVAKVLRKYNLGCIGCMGAQNESLEQGCSAHGLDVNEVLKDLNAIGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UV8</accession>
    <name>Q39UV8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA gyrase inhibitor YacG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yacG</name>
        <name evidence="2" type="ordered locus">Gmet_1735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with GyrB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA gyrase inhibitor YacG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31966.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365863.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1735"/>
    <dbReference type="EnsemblBacteria" id="ABB31966">
        <property type="protein sequence ID" value="ABB31966"/>
        <property type="gene ID" value="Gmet_1735"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1735"/>
    <dbReference type="eggNOG" id="COG3024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_178280_3_2_7"/>
    <dbReference type="OMA" id="WAAEEHK"/>
    <dbReference type="OrthoDB" id="2071775at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008657">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00649">
        <property type="entry name" value="DNA_gyrase_inhibitor_YacG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005584">
        <property type="entry name" value="DNA_gyrase_inhibitor_YacG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36150">
        <property type="entry name" value="PTHR36150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03884">
        <property type="entry name" value="YacG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31966.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="63" mass="7248" checksum="A60A5C1E618037C2" modified="2012-10-31" version="2">MSEKPITIVPCPRCRKETPWQGNPFRPFCSERCKTMDLAAWADEEYRIASEDTPGDDESDENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UW0</accession>
    <name>Q39UW0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helix-turn-helix SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1733</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513370.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1733"/>
    <dbReference type="EnsemblBacteria" id="ABB31964">
        <property type="protein sequence ID" value="ABB31964"/>
        <property type="gene ID" value="Gmet_1733"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1733"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005533_4_1_7"/>
    <dbReference type="OMA" id="NTNHGEL"/>
    <dbReference type="OrthoDB" id="1213908at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031725">
        <property type="entry name" value="ASMT_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="O_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11746">
        <property type="entry name" value="PTHR11746"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16864">
        <property type="entry name" value="Dimerisation2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005739">
        <property type="entry name" value="O-mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Dimerisation2" evidence="5">
        <location>
            <begin position="11"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransf_2" evidence="4">
        <location>
            <begin position="127"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="3">
        <location>
            <begin position="218"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2 3">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005739-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="334" mass="35986" checksum="A821659E16D7D1C3" modified="2005-11-22" version="1">MEEKTWTPAELLQLSGGYWSACALHAAVALDVVTPLAGEALTAAEVAGRLAVDVRGVAMLLDALAAMALVHKREDRYEAAPFAARYLAKSSPEYLGYIIMHHHHLMAGWSQLDEAVRRGAPVRESASHGDDEGARENFLMGMFNLAMQSAPKVVPLIDLTGRKRLLDLGGGPGTWAIHFCLQNPGLDAIVYDLPTTRRFAEETVARFGLADRVGFVAGDFLENDTPKGFDVVWLSHILHAYGPDQCAVILEKAVRALEPGGLLLVQEFVLDDTRSGPLFPALFSLNMLVGTTAGQSYSEGELSSMMAAAGLRDVRRLPLELPNGAGIIAGTVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V19</accession>
    <name>Q39V19_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511390.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1674"/>
    <dbReference type="EnsemblBacteria" id="ABB31905">
        <property type="protein sequence ID" value="ABB31905"/>
        <property type="gene ID" value="Gmet_1674"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1674"/>
    <dbReference type="eggNOG" id="ENOG502Z86S">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036877_1_0_7"/>
    <dbReference type="OMA" id="VAECMQF"/>
    <dbReference type="OrthoDB" id="1307370at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021847">
        <property type="entry name" value="DUF3443"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11925">
        <property type="entry name" value="DUF3443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="417" mass="42900" checksum="EBCEC111A6D2D64A" modified="2005-11-22" version="1">MKSNKAVSLILLVGLVAGCGGGGGGGGGGGGGGGGDGGGSGGGTNTAANVLDITVNDPSYPNKPTVTVTICEPDTGKCQTVDNVLLDTGSYGLRIFKQAAPNISLPQVLVGSAPIAECIQYLDNTGTWGPVRIADVKLGGETAANIPIQIIDATYFQGNIPSQCQSPQVKGLDTNPDDAGYNGILGVGLFVEDCGDRCARSDTNDVYFTCSGSNCSSTPVPLASQVQNPVAHLDQDNNGVIVQMTSIPAGGSRTAGGKLILGIDTQTNNASSGTTPYFIDNSGYYAGYFTTKFNGTTFDTSFIDSGSNGLFFNVPTSLLPVCSSPHQDWYCPPVSLSSPLQLEAINYGNNATGGRVTFYIGNATSLFSTSNSAFAELGGPGFGSSFDWGLPFFYGRSVFVGIDRRNSSLGTGPYWAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V55</accession>
    <name>Q39V55_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bis-adenosyl-polyphosphate hydrolase, FHIT domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511426.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1638"/>
    <dbReference type="EnsemblBacteria" id="ABB31869">
        <property type="protein sequence ID" value="ABB31869"/>
        <property type="gene ID" value="Gmet_1638"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1638"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_1_2_7"/>
    <dbReference type="OMA" id="YNPGHVM"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01275">
        <property type="entry name" value="FHIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039383">
        <property type="entry name" value="FHIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="22"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="3">
        <location>
            <begin position="117"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR639383-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="162" mass="18677" checksum="587D10F8D24BBD02" modified="2005-11-22" version="1">MERIWAPWRMDYILDEKPHGCIFCLDARTDEDRQNLVLYKTPLSLVMLNRYPYTNGHLMVAPRHHTAELDSLTDVEMLDLFRTVRLCRSVLEEEASPQGFNIGLNLGRAAGAGIEDHLHIHIVPRWNGDTNFMTVVADVRVVPEGLLTTYDRLYPRFAARTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VB8</accession>
    <name>Q39VB8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(R)-methylmalonyl-CoA mutase, adenosylcobamide-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511491.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1574"/>
    <dbReference type="EnsemblBacteria" id="ABB31806">
        <property type="protein sequence ID" value="ABB31806"/>
        <property type="gene ID" value="Gmet_1574"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1574"/>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128233_0_0_7"/>
    <dbReference type="OMA" id="VYTGLHQ"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="5"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="134" mass="14339" checksum="4705E353E04D0579" modified="2005-11-22" version="1">MTERTLRILVGKPGLDGHDRGAKIIARAFRDAGFEVIYTGLHQTPEQIVSAAIQEDVDAVGLSILSGAHNALLPRVCQLLKEKKADDIVVFGGGVIPDDDIPGLKRAGVSEVFTPGTSTESIVQWVRENVAPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VC2</accession>
    <name>Q39VC2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sulfite reductase subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511495.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1570"/>
    <dbReference type="DNASU" id="3738507"/>
    <dbReference type="EnsemblBacteria" id="ABB31802">
        <property type="protein sequence ID" value="ABB31802"/>
        <property type="gene ID" value="Gmet_1570"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1570"/>
    <dbReference type="eggNOG" id="COG2221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072599_0_1_7"/>
    <dbReference type="OMA" id="KVRMHDF"/>
    <dbReference type="OrthoDB" id="1128731at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="194"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="320" mass="35054" checksum="2895C0535CCF5F19" modified="2005-11-22" version="1">MSDEKKSTDIDLKNLKAGGFIKERGKDLFTVRLRVPGGRMPVARLKKIAEVAEKYGQGMVHLSVRQSVELININFRDFDAVVAELGEGTQKVASCGARVRVPTACGGCEYNPNGLVDTQKSALEVDEKLFGTSTGHHKFKVGFAGCPFDCPKSATNDVGFQGAIWPVLYADECIGCGLCDKSCTEDAIVMGDDGKPRFIPENCLYCGDCLKVCPSEAWRAEKKGYTVRIGGKWGRRPLVGTLFAEFLPEEQVFDFIAAVLDWYKEKAEGQGRIRLGDVIRAEGPDALLGYLRERFPAAVVDATIPPQRIATQIGKEKRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VD5</accession>
    <name>Q39VD5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heavy metal transport/detoxification domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1555</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511512.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1555"/>
    <dbReference type="EnsemblBacteria" id="ABB31789">
        <property type="protein sequence ID" value="ABB31789"/>
        <property type="gene ID" value="Gmet_1555"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1555"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1803422_0_0_7"/>
    <dbReference type="OMA" id="CGSCVKH"/>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223533" evidence="2">
        <location>
            <begin position="27"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="3">
        <location>
            <begin position="36"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="139" mass="14352" checksum="BE92095C77DEA947" modified="2005-11-22" version="1">MRRGQISKIFRLVMVAALGVVLGAGAALSSGSPEAVTELKSTGISCGGCVSKITKSLETVPGVASVDVNIEAGLVSVWHDNTATPQKLAATVSDAGYQSTVQETMSADSYREKTRMSGPTQARSGGCGCCDKSKKPERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VL3</accession>
    <name>Q39VL3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511591.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1477"/>
    <dbReference type="EnsemblBacteria" id="ABB31711">
        <property type="protein sequence ID" value="ABB31711"/>
        <property type="gene ID" value="Gmet_1477"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1477"/>
    <dbReference type="HOGENOM" id="CLU_768950_0_0_7"/>
    <dbReference type="OMA" id="NPLIEAW"/>
    <dbReference type="OrthoDB" id="1024384at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="360" mass="40224" checksum="D94EB315E1D9F8E8" modified="2005-11-22" version="1">MITNAVIPLARRAMSTHPALMGMATATSGFIRQMSIKTFSPRLRRRELALRNELPSIHTVRNHLFKEKGQGEVPTIVIGGFVPDATEAVEFQREIFRRHGSVYYINFSRSGFSAPFFFAQLADLIEELNRKGQKPIIFSVSFGCSLVSRFFRDGHDTGLSIRGTVLTSPVLCIEDLVRPEGERRGGVRMLESNLKRILRAETTKGDELNRQIERARRCFQALFEAGAENRVLSNRHLSIRKRIMGVLESTSCLGGYERVMALRDAPTTTDGTVFGGPALVLLAEKEDELLVNTSPTLAALRDSEIRARLFPRGKVRTVMSPASGDAVAHASLIFHQHCYNPLIEAWYDRLTTPLRLAVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VM7</accession>
    <name>Q39VM7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HATPase_c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511607.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1463"/>
    <dbReference type="EnsemblBacteria" id="ABB31697">
        <property type="protein sequence ID" value="ABB31697"/>
        <property type="gene ID" value="Gmet_1463"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1463"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_741375_0_0_7"/>
    <dbReference type="OMA" id="TRRIPND"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="HATPase_c" evidence="2">
        <location>
            <begin position="311"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="426" mass="48248" checksum="014CAECA2CED03DE" modified="2005-11-22" version="1">MKWRSMLDRAAVRGLRSGRRWRPLINRRMVTGWLGRRYEALYASRRRIFGANFLSGLLIAFSVFFLGQTGIFGAVLDFFIRLLLTAKLMLLERRLMPMPFLPTAASFVTVVAAAALICTHVRSVAVVVALNAILCVAIIGINLFVPIPFPLPLGTVPVVLLITLGALLDWLLERRLLRRRSTLSAERQETSFTILRHIAHSVNPTIQMALAPLRDLHDHLERRSLTGDIIGTRRDGSAERVEDALAATELGLRQIREILDTTEDLFGNRIEDRDFEEVDLRELFAREIIPLFPHPRFSLRTEFNCVNTVRLHRPSFVQAVKNLIRNAEVHGFPPGFQRDEGLWVRFSISRTVKEIVIDYENNGLPFPLGLRTKDFLAFGTKGKGSPGKGLGGAWVAKFIEIHNGTFSKLGNDPVRFRMTLPRRRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VX1</accession>
    <name>Q39VX1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ</fullName>
            <ecNumber evidence="4">2.1.1.200</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA (cytidine(32)/uridine(32)-2'-O)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA Cm32/Um32 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">trmJ</name>
        <name evidence="6" type="ordered locus">Gmet_1369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>S-adenosyl-L-methionine + uridine(32) in tRNA = 2'-O-methyluridine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42936"/>
            <dbReference type="Rhea" id="RHEA-COMP:10107"/>
            <dbReference type="Rhea" id="RHEA-COMP:10290"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.200"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>cytidine(32) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(32) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42932"/>
            <dbReference type="Rhea" id="RHEA-COMP:10288"/>
            <dbReference type="Rhea" id="RHEA-COMP:10289"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.200"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.200" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513139.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1369"/>
    <dbReference type="EnsemblBacteria" id="ABB31603">
        <property type="protein sequence ID" value="ABB31603"/>
        <property type="gene ID" value="Gmet_1369"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1369"/>
    <dbReference type="eggNOG" id="COG0565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056931_0_1_7"/>
    <dbReference type="OMA" id="ELCQAVC"/>
    <dbReference type="OrthoDB" id="1637132at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004384">
        <property type="entry name" value="RNA_MeTrfase_TrmJ/LasT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42786">
        <property type="entry name" value="PTHR42786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004808">
        <property type="entry name" value="LasT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00050">
        <property type="entry name" value="rRNA_methyl_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="5">
        <location>
            <begin position="9"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="248" mass="27117" checksum="06F75B7B8A6B0295" modified="2005-11-22" version="1">MTVSMKNNISVILVEPQSPGNVGMVCRAMKNMGLAELRIVKGCPLDHPEAYKFAVSAKDLLEGARVFPSLEEALADTELSVATTRRHGKYRQEIYSPGEIAGKIVTNLAGNRAALVFGREDSGLTTDELSLCRWHATIPTSAEYGSLNLAQAVLIFCYELFAGLGEGTVAGEARTLAGSAAQEALFGQMERTLLRIGFLNPQNPDHIMRTVRRIFSRAELDDREVAILRGMMTQIDWAADQFKGKKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VX6</accession>
    <name>Q39VX6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoglutarate:ferredoxin oxidoreductase, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">korC</name>
        <name evidence="3" type="ordered locus">Gmet_1364</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513144.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1364"/>
    <dbReference type="EnsemblBacteria" id="ABB31598">
        <property type="protein sequence ID" value="ABB31598"/>
        <property type="gene ID" value="Gmet_1364"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1364"/>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_0_0_7"/>
    <dbReference type="OMA" id="EVSWMPS"/>
    <dbReference type="OrthoDB" id="1777574at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="13"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="182" mass="19159" checksum="8831B3E39AB4A17C" modified="2005-11-22" version="1">MAGRYEIRFSGAGGQGLILAGVIMAEAASIYDGIQAVQSQSYGPEARGGASKSEVIISDGPIDYPKVTKCDALLALTQEACDKYSHDLKEGGLLLIDSDLVLREPAGNFKVTKFNITNTAKNEIGREIVTNIVALGAMVALTGAVTKEAAEKAVLARVPEAFLELNKKAFHVGFDKAMAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W11</accession>
    <name>Q39W11_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514699.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1328"/>
    <dbReference type="CAZy" id="GT11">
        <property type="family name" value="Glycosyltransferase Family 11"/>
    </dbReference>
    <dbReference type="DNASU" id="3740300"/>
    <dbReference type="EnsemblBacteria" id="ABB31563">
        <property type="protein sequence ID" value="ABB31563"/>
        <property type="gene ID" value="Gmet_1328"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1328"/>
    <dbReference type="eggNOG" id="ENOG502ZC3Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043399_3_1_7"/>
    <dbReference type="OMA" id="CITIRRG"/>
    <dbReference type="OrthoDB" id="1825163at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008107">
        <property type="term" value="F:galactoside 2-alpha-L-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002516">
        <property type="entry name" value="Glyco_trans_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11927">
        <property type="entry name" value="PTHR11927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01531">
        <property type="entry name" value="Glyco_transf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="294" mass="34330" checksum="AD9A46710BD1EC83" modified="2005-11-22" version="1">MDIHVLSYGLGNQLSQYAFFINRRQLMQRAYAFYAFKQHNGYELDRIFGLKEGLPWYLQFVRVVFRLGISRRFYSKRTADFVLSLFRIKVIDEAYNYEFDPSLLKPWFGIRILYGGWHDSRYFHPSEAAVRTAFSFPPLDDVNDAILQQIDAVYGVSIHVRRGDYLKGINSNLFGGIATLEYYRNAIGWAITYCKHRSLEIKFYVFSDDIDWCKQNLGLRDAVYVSGNSKTDSWKDILLMSHCRANIIANSTFSWWAAWLNQQPNKVVICPTKFINTDSPNQTIYPAAWHQIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W14</accession>
    <name>Q39W14_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamate--dTDP-6-deoxy-D-xylo-hex-3-ulose 3-aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fdtB</name>
        <name evidence="4" type="ordered locus">Gmet_1325</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514702.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39W14"/>
    <dbReference type="STRING" id="269799.Gmet_1325"/>
    <dbReference type="EnsemblBacteria" id="ABB31560">
        <property type="protein sequence ID" value="ABB31560"/>
        <property type="gene ID" value="Gmet_1325"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1325"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_6_0_7"/>
    <dbReference type="OMA" id="GLERMKY"/>
    <dbReference type="OrthoDB" id="1006364at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="368" mass="41003" checksum="7D990A245109D603" modified="2005-11-22" version="1">MIIPFLDLKSPYLELQAELDDAYRRVMESGWYILGKEVEAFEAEFAEYCQVKHCIGVGNGLEALHLILRAMDIGPGDEVIVPSNTYIATWLAVSYTGATPVPVEPDVITYNLNPVLIEVAITKNTKAILPVHLYGQTADMDPINAIAARYGLKVVEDVAQSHGARYKGRRAGSLGDAAGFSFYPGKNMGAFGDGGAITTNDDQLAKKIRVLRNYGSQIKYHNEIKGYNSRLDELQAAFLRVKLTKLDEWNERRKQIAASYLDGLKSNEHLVLPHVPEWADPVWHLFVLRCKNRDVLQRQLNEAGIGTMIHYPIPPHLQPAYSELGFSEGTFPISENIHVEVLSLPMGPSMSKAQAEFVIKTMNRILIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W40</accession>
    <name>Q39W40_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor diguanylate cyclase, GAF domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512068.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1298"/>
    <dbReference type="EnsemblBacteria" id="ABB31534">
        <property type="protein sequence ID" value="ABB31534"/>
        <property type="gene ID" value="Gmet_1298"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1298"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_24_7"/>
    <dbReference type="OMA" id="ENARNFR"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="214"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="353" mass="39791" checksum="4180FA23B93850EE" modified="2005-11-22" version="1">MEHSLKCTIELLEEEVSALRELIEVARMVVSTLELDQVLLEILTSAMRFADASAGSIVLYDTVQGGLTLHAHQGFTPEFVLAERWEIRPGGVTERVISGGEILFVNDTEDNPLLVDPIVIREGIRSQACIPLKVQSRLAGILYLCDFVPREFDRERMKLLDVLASFAAMAIDNAQLHERTRLMAITDALTGLYNRRYFQQMFSRELNRAKRYGNPLSLIMMDVDDFKKFNDTYGHPLGDKLLGSMGDILTEALRNTDFAFRYGGEEFIVLLPETDFSSALNVAERLRESVEQKSVDEMRGIALNAVTVSVGVVSYPQDGETSDDLLNGVDELLYRAKEYGKNRVYYRTMGEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W42</accession>
    <name>Q39W42_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SMR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512070.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1296"/>
    <dbReference type="EnsemblBacteria" id="ABB31532">
        <property type="protein sequence ID" value="ABB31532"/>
        <property type="gene ID" value="Gmet_1296"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1296"/>
    <dbReference type="eggNOG" id="COG2840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_109169_1_0_7"/>
    <dbReference type="OrthoDB" id="1888882at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SSF160443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="1">
        <location>
            <begin position="15"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="90" mass="10125" checksum="EEFA6E6F23017C1E" modified="2005-11-22" version="1">MIEDLTIELPIDGTLDLHTFRPGEVKDLVPDYLAACRERGIYSVRIIHGKGTGTLRRTVHAILERLDVVASFRLAGEDAATLVELWRDRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W56</accession>
    <name>Q39W56_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Lipopolysaccharide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lptB</name>
        <name evidence="5" type="ordered locus">Gmet_1282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512084.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1282"/>
    <dbReference type="EnsemblBacteria" id="ABB31518">
        <property type="protein sequence ID" value="ABB31518"/>
        <property type="gene ID" value="Gmet_1282"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1282"/>
    <dbReference type="eggNOG" id="COG1137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="LPMYQRA"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03218">
        <property type="entry name" value="ABC_YhbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030921">
        <property type="entry name" value="LPS_export_LptB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04406">
        <property type="entry name" value="LPS_export_lptB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="246" mass="26706" checksum="BC45CBCC0BA194CD" modified="2005-11-22" version="1">MAANSADMVLQAHGLRKGFGKRVVVNGVDLRVATGEVVGLLGPNGAGKTTTFYMVVGLCRPDGGQVFIGDEEITALPMYQRARMGISYLPQEPSVFRKLTVEENILAVLETMDLSSSERRDRAAELIGEFKIDHIAKSKGYALSGGERRRVEIARALATDPLFILLDEPFAGIDPIAVIDIQGIITELKARGIGILISDHNVRETLGVCDNAYIMSAGEVIEYGDPVKIAGSKQAREIYLGEKFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W92</accession>
    <name>Q39W92_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_1246</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; Fe-Mo cofactor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. NifB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512122.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31482">
        <property type="protein sequence ID" value="ABB31482"/>
        <property type="gene ID" value="Gmet_1246"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1246"/>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_3_1_7"/>
    <dbReference type="OMA" id="PTEACNF"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="UniPathway" id="UPA00782"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026322">
        <property type="entry name" value="Geopep_mat_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005980">
        <property type="entry name" value="Nase_CF_NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023867">
        <property type="entry name" value="Sulphatase_maturase_rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43787:SF3">
        <property type="entry name" value="PTHR43787:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01384">
        <property type="entry name" value="thioether_bond_formation_requi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04280">
        <property type="entry name" value="geopep_mat_rSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="77"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="432" mass="48273" checksum="DD3FB5884D42B6FB" modified="2005-11-22" version="1">MHLSRYLKRYSCHERPGHLLLFSTRTAAIAIVPEKVIANIEQGAISPATAETLSRLGFLVPDTEVEAEQVRQLFTTINGERTVATIIAVLNMDCNLACTYCFEGGLKGKRYMDHATAERLVSFLDRHYLAEGIAPNLDFYGGEPLLSLDLIRSITTRLKERAAGRGLSCSFGMVSNGTLLTGDVACELASLGVTGVQVTLDGTRENHDRYRPFVSGKGSFDVIVRNLLEACDLLDISIVCNYTQENYWGFPSLLDYLLEVGLKPERIAAVNFAPISRIGTGELPPEFNDSCASHNMPWVYESQLFLRQEALKRGYSVAKLRPPLCMVELARDLVVTHEGELYKCPAFMGRKGLAVGTLEAGVTEYRESHNLDLWNNEECLDCEYLPFCYGGCRLSRLAQTGEINGVDCRRDYYEASLERYVRQEMANTSRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WA3</accession>
    <name>Q39WA3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31471.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365787.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1235"/>
    <dbReference type="EnsemblBacteria" id="ABB31471">
        <property type="protein sequence ID" value="ABB31471"/>
        <property type="gene ID" value="Gmet_1235"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1235"/>
    <dbReference type="eggNOG" id="COG0601">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036879_1_1_7"/>
    <dbReference type="OMA" id="QLPWFTL"/>
    <dbReference type="OrthoDB" id="1479518at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045621">
        <property type="entry name" value="BPD_transp_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19300">
        <property type="entry name" value="BPD_transp_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="98"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31471.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="326" mass="36059" checksum="B7DD8EDB089536A1" modified="2012-10-31" version="2">MITYLAKRLIMMVPLLLGITLISFVVIRLAPGEPVEAMTAMSPKITAETRQRLREFYGLDKPLHVQYATWLKQVATLDFGRSFAPDNRPVTDKIKERIPVTISLNVIALILEFGLAIPIGIFAATHRDTLYDKGITIFVFLGFAVPTFWLALLLMYFFGVKLGWLPISGLHSLGSETLSPMAWFVDLAKHLILPVSVATFGSLAGLSRYMRSTMLEVIRQDYITTARAKGLTERAVIYRHALRNALLPVITLLGFSLPGLIGGSVIFETIFAIPGMGQLFYQGVMGRDYPLVMGILVIGAFLTLVGNLLADLCYAMADPRIRHGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WB8</accession>
    <name>Q39WB8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512150.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1219"/>
    <dbReference type="EnsemblBacteria" id="ABB31456">
        <property type="protein sequence ID" value="ABB31456"/>
        <property type="gene ID" value="Gmet_1219"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1219"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="RVWADSR"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="175"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="134"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="396" mass="44981" checksum="E3D535C43B87D297" modified="2005-11-22" version="1">MEFQQYPDVRLSLLYVEDEPEIRELLRSVLVRKFPNVDIQTAENGMAGLELFREQRPDIILTDIRMPVMDGIQMTRRILEEDPAVSVIIISACSETDYLLEAIKMGINRYVLKPINHKLLFEAIDDCAARIIHGRQVKAQNELIRRLNEELEQRVADRTAELEASNRELQAFCYSVAHDLSTPLRGINGYSNILLEEYSDKLDDEGKSYLERMGAAAERMGQLINDLLELSRVTRRELHREKIDLSHLAHRIVMDLQQHDPDRQAEVIIAENIMDEGDPILIRLALENLLGNAWKYTTRVSSPRIEFGTCITNGETVYFVSDNGIGFDMAYVHKLFIPFQRLHGMGEYGGTGVGLAAVQRIISRHGGRIWAEGEPGKGATFYFSLRRPAAGALVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WE1</accession>
    <name>Q39WE1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PASTA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1196</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512174.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1196"/>
    <dbReference type="EnsemblBacteria" id="ABB31433">
        <property type="protein sequence ID" value="ABB31433"/>
        <property type="gene ID" value="Gmet_1196"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1196"/>
    <dbReference type="eggNOG" id="COG2815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466738_0_0_7"/>
    <dbReference type="OMA" id="IEINDTH"/>
    <dbReference type="OrthoDB" id="1713167at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005543">
        <property type="entry name" value="PASTA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03793">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00740">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51178">
        <property type="entry name" value="PASTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50104">
        <property type="entry name" value="TIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="3">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="4">
        <location>
            <begin position="227"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="4">
        <location>
            <begin position="311"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="PASTA" evidence="4">
        <location>
            <begin position="383"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="584" mass="62995" checksum="7ECA5CD34C9ECC41" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WG8</accession>
    <name>Q39WG8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Diadenylate cyclase</fullName>
            <shortName evidence="6">DAC</shortName>
            <ecNumber evidence="6">2.7.7.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cyclic-di-AMP synthase</fullName>
            <shortName evidence="6">c-di-AMP synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dacA</name>
        <name evidence="8" type="ordered locus">Gmet_1168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>2 ATP = 3',3'-c-di-AMP + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:35655"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:71500"/>
            <dbReference type="EC" id="2.7.7.85"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Probably a homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate cyclase family. DacA/CdaA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.85" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365777.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1168"/>
    <dbReference type="DNASU" id="3740395"/>
    <dbReference type="EnsemblBacteria" id="ABB31406">
        <property type="protein sequence ID" value="ABB31406"/>
        <property type="gene ID" value="Gmet_1168"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1168"/>
    <dbReference type="eggNOG" id="COG1624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028956_0_0_7"/>
    <dbReference type="OMA" id="YQLYSWF"/>
    <dbReference type="OrthoDB" id="1300262at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004016">
        <property type="term" value="F:adenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106408">
        <property type="term" value="F:diadenylate cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019932">
        <property type="term" value="P:second-messenger-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01499">
        <property type="entry name" value="DacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034701">
        <property type="entry name" value="CdaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045585">
        <property type="entry name" value="CdaA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036888">
        <property type="entry name" value="DNA_integrity_DisA_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003390">
        <property type="entry name" value="DNA_integrity_scan_DisA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012505">
        <property type="entry name" value="YbbR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19293">
        <property type="entry name" value="CdaA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02457">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07949">
        <property type="entry name" value="YbbR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143597">
        <property type="entry name" value="SSF143597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00159">
        <property type="entry name" value="TIGR00159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51794">
        <property type="entry name" value="DAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="DAC" evidence="7">
        <location>
            <begin position="77"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="471" mass="52092" checksum="5662CEF7ADC1D9BB" modified="2005-11-22" version="1">MVPVIRWQDVADIIIMSFLAYQLYSWFRHTRAMQVLIGMVFLVGVYFITKNLGLFMTSWILQELGTVLFVLIIVIFQAEIRQALYRFSLLRNFFGRQDGGGLIDLADISSTIFRLAKERTGAIVVFQRHESLDDYLLHGVPLDSIPNGQLIECIFQDGTPLHDGAVIVKEGRITQASCHLPLSMKTELPRHFGTRHRAGIGLSERCDAAVVIVSEERGEVGLALAGELEAVATAESLAEKLQGLLYPQRQEKVHISLGQRLVSNLVPKLVTTLVVFVSWLIITTKQGAIFTVTVPIKFHNLPGNAVLLKSSPEEVEAQLKVFSSLIPSPKQLDVVADLDLAKVREGSNTLAITESDLNLPLGVVVTSVNPSVVKVSISKKIKKALQVRPVLKGTPSGRQRLQRVRVEPQEVVVEGPEHVLAGLDTLNTEVINLEGIRQSTVVESRLVSPSPQLRILNDEPVRVRIVTTGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WM1</accession>
    <name>Q39WM1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bidirectional NAD-reducing hydrogenase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hoxL</name>
        <name evidence="4" type="ordered locus">Gmet_1113</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513769.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1113"/>
    <dbReference type="EnsemblBacteria" id="ABB31353">
        <property type="protein sequence ID" value="ABB31353"/>
        <property type="gene ID" value="Gmet_1113"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1113"/>
    <dbReference type="eggNOG" id="COG3259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044556_0_0_7"/>
    <dbReference type="OMA" id="QNNLAMN"/>
    <dbReference type="OrthoDB" id="1967820at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="476" mass="52332" checksum="E57708145E274E5D" modified="2005-11-22" version="1">MSRTITIDPVTRIEGHATITIRLDDAGSVADARLHVTEFRGFEAFCVGRSIWEMPGITARICGICPISHSIASARAGDAILGVDIPPAAEQLRRIANLASLIQSHALSFFHLCAADLLLGMDHDPSRRSLWGLLESRPDVARRGIRLRQIGQQIVSNLAGERVHPSWAVPGGVREPLDAERRRKVVELLPEGIAIIRSAFELLDEIYGRHGAEVGTYGDFPSLFAGLVGEDGGLEHYDGMLRFTDSSGAVVEEVPPDHYDLAIGERSEPWSYMKFPFYRNHAGRDGGGMFRVGPLARLNLCERAGTPEADRELQTFRQLRGTGGVVTGSFHYHHARLIEILHALERIGELLDDPAILDRHVRSEAGVNRRHGVGFCEAPRGTLFHDYEVDDDGLILRLNLLIATGQNNLAMNRTILEVARSHIKGGKVSEGILNRIEHGIRAYDPCLSCATHVYGRMPFQVLLLAPDGTVVDEIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WT3</accession>
    <name>Q39WT3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513225.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1051"/>
    <dbReference type="EnsemblBacteria" id="ABB31291">
        <property type="protein sequence ID" value="ABB31291"/>
        <property type="gene ID" value="Gmet_1051"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1051"/>
    <dbReference type="eggNOG" id="COG4190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130787_1_1_7"/>
    <dbReference type="OrthoDB" id="1981213at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="120" mass="13255" checksum="E3B3B706C74562C7" modified="2005-11-22" version="1">MKIKEISVGIQSARGALDDFIAAGDTVARGEVVAEETSIYFTSMEAFRKALTPKRLELIHIIKTEKPVSINHLAKLAHRNIKNVAEDVKFLVQVGLVETTGNRALAPRVDYDEIQLKIAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WZ6</accession>
    <name>Q39WZ6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chorismate dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.151</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">mqnA</name>
        <name evidence="4" type="ordered locus">Gmet_0986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>chorismate = 3-[(1-carboxyvinyl)-oxy]benzoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:40051"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="4.2.1.151"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.151" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514381.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0986"/>
    <dbReference type="EnsemblBacteria" id="ABB31228">
        <property type="protein sequence ID" value="ABB31228"/>
        <property type="gene ID" value="Gmet_0986"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0986"/>
    <dbReference type="eggNOG" id="COG1427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059898_0_0_7"/>
    <dbReference type="OMA" id="WGLARTG"/>
    <dbReference type="OrthoDB" id="1062841at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00995">
        <property type="entry name" value="MqnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030868">
        <property type="entry name" value="MqnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37690">
        <property type="entry name" value="PTHR37690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="278" mass="30623" checksum="30D080D8D8E186FC" modified="2005-11-22" version="1">MSLTIGHIEYSNCTPIFTALQRSMDCSGYSFVRGVPAHLNRLLAMGEIDVCPSSSIEYGKYPDRYLVLPDLSISAVGPVKSVLLFSRVPLERLDGAVIGMTTESDTSVNLLRIILTTFQGFTNSFERTPLPLAEALDSYPALLLIGDRALKGALTGGGYHIYDLGDLWYRATGLPFVFALWLLRREAAENKPHEVARLAVDVARAKRIAYDSYPEIAAQAPEREWIDSAVLVDYWRTISYDLTPAHLKGVRLFYNYAASLGVLPAAPDVRLYGESGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X22</accession>
    <name>Q39X22_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_0960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514354.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0960"/>
    <dbReference type="EnsemblBacteria" id="ABB31202">
        <property type="protein sequence ID" value="ABB31202"/>
        <property type="gene ID" value="Gmet_0960"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0960"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_29_7"/>
    <dbReference type="OMA" id="FGIAQEH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="186"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="276"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="230"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="531" mass="57477" checksum="20E450AD43A252DB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XL7</accession>
    <name>Q39XL7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31007.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513510.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0765"/>
    <dbReference type="EnsemblBacteria" id="ABB31007">
        <property type="protein sequence ID" value="ABB31007"/>
        <property type="gene ID" value="Gmet_0765"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0765"/>
    <dbReference type="eggNOG" id="COG1235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044538_2_1_7"/>
    <dbReference type="OMA" id="CGPDFRQ"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="34"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31007.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="251" mass="27935" checksum="C791A7E514BF1BF4" modified="2012-10-31" version="2">MKITILGSGTSTGVPMVGCHCPVCSSSDPKDKRTRSSIMIETAGKYILVDTSPDLRRQALRQRIPYIDAVLLTHPHADHINGIDDLRGFHFIHRRVIPCHGSRTTMEAVQRNFSYIFRGLEVVGYSPLMEAHIVNEPFALFGQSIVPIHLYHGAMPATGYRIDGAAYLTDCSRIPDSSLSLLTGLDILIMDALRYTPHENHFNIEGALRIVEQLKPKRAILTHLTHEVAHGDESRLPEGVEFAYDGMEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XQ6</accession>
    <name>Q39XQ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase or acyltransferase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514443.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0726"/>
    <dbReference type="ESTHER" id="geomg-q39xq6">
        <property type="family name" value="Carbon-carbon_bond_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30968">
        <property type="protein sequence ID" value="ABB30968"/>
        <property type="gene ID" value="Gmet_0726"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0726"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_13_6_7"/>
    <dbReference type="OMA" id="HCIHHDA"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="27"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="297" mass="33125" checksum="0F90B1D1AACE20C4" modified="2005-11-22" version="1">MGDRLTFVYGPGVDISYRVVGHGPTPVVFVHGFAAARTTWNDIVPLFPAERFTLYLIDLKGFGFSSKPRTGSYAIEEQAAVTTAFLKAKGLSRVILTGHSLGGAIALLVTLQARDRGDTGLVARLILVACSAYPQKLPRLMGWLRIPFLARIGMALIPVRTIVRYTLARVFHDTRAITPERIRRYEHCFGRRGMAGVLIRSARAIDPDSYGAITARYREIDIPTLIVWGKEDRIVRIGQGKRLAEEMPDARLAVIDGCGHNPHEERPRETLAAIMEFLGNGEEREEGSGRFWREARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XU6</accession>
    <name>Q39XU6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514077.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30928">
        <property type="protein sequence ID" value="ABB30928"/>
        <property type="gene ID" value="Gmet_0686"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0686"/>
    <dbReference type="HOGENOM" id="CLU_1308645_0_0_7"/>
    <dbReference type="OMA" id="EMILPYF"/>
    <dbReference type="OrthoDB" id="1531082at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="210" mass="24003" checksum="1BCECDC8C3E88105" modified="2005-11-22" version="1">MTQDKDDRKRPQLRLVVNNPELRGSRPATGEDASIPFEVLIAKRHELRADFFKGIAPQHVKAYERIERHLERRGWLYGLDPQHGRLMVIPAATACPEVLEHGGSPQDELLLFVADDPTGLGLCLCLEIILPFWSDDDAVMEEALIYAPIYPYGSLFLEENRNDGYLDLIYRLSFPLYPPAPTERLLEKLFAVARYELRETLIGLDEFPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XW0</accession>
    <name>Q39XW0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrogenase-associated ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fdxN</name>
        <name evidence="8" type="ordered locus">Gmet_0672</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514063.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0672"/>
    <dbReference type="EnsemblBacteria" id="ABB30914">
        <property type="protein sequence ID" value="ABB30914"/>
        <property type="gene ID" value="Gmet_0672"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0672"/>
    <dbReference type="eggNOG" id="COG1149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155272_0_0_7"/>
    <dbReference type="OMA" id="ICPKKCY"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014283">
        <property type="entry name" value="FdIII_4_nif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02936">
        <property type="entry name" value="fdxN_nitrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="18"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="87" mass="9703" checksum="99018F5D16FEB6F1" modified="2005-11-22" version="1">MAYITGLRRNKSEYTPQFVVSVDEETCIGCARCFKVCAHDVLTFEEVDEDDSAKMFMKVTNPGNCIGCQACGRTCSKKCFSFEPVVI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XZ5</accession>
    <name>RL24_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplX</name>
        <name type="ordered locus">Gmet_0637</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514247.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XZ5"/>
    <dbReference type="SMR" id="Q39XZ5"/>
    <dbReference type="STRING" id="269799.Gmet_0637"/>
    <dbReference type="EnsemblBacteria" id="ABB30879">
        <property type="protein sequence ID" value="ABB30879"/>
        <property type="gene ID" value="Gmet_0637"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0637"/>
    <dbReference type="eggNOG" id="COG0198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093315_2_3_7"/>
    <dbReference type="OMA" id="HVKPTQE"/>
    <dbReference type="OrthoDB" id="2040741at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01326_B">
        <property type="entry name" value="Ribosomal_L24_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="KOW_RPL26/RPL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003256">
        <property type="entry name" value="Ribosomal_L24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12903">
        <property type="entry name" value="PTHR12903"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17136">
        <property type="entry name" value="ribosomal_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01079">
        <property type="entry name" value="rplX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000241604" description="50S ribosomal protein L24">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01326"/>
        </source>
    </evidence>
    <sequence length="108" mass="12077" checksum="ADB73241C87FF2E3" modified="2005-11-22" version="1">MLDKKFHVKKGDTVSVIAGKDKSKTGKVIRILPKKDGVLVEGLNMVKRHMRARGNEPGGIVEKENPLHVSNVMLYCDKCKKPVRSKMNVLEDGKKVRVCIKCGDSFDK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XZ9</accession>
    <name>RL16_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplP</name>
        <name type="ordered locus">Gmet_0633</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514243.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XZ9"/>
    <dbReference type="SMR" id="Q39XZ9"/>
    <dbReference type="STRING" id="269799.Gmet_0633"/>
    <dbReference type="EnsemblBacteria" id="ABB30875">
        <property type="protein sequence ID" value="ABB30875"/>
        <property type="gene ID" value="Gmet_0633"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0633"/>
    <dbReference type="eggNOG" id="COG0197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078858_2_1_7"/>
    <dbReference type="OMA" id="KGAVEYW"/>
    <dbReference type="OrthoDB" id="1786618at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01342">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_L10e/L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_L10e/L16_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000114">
        <property type="entry name" value="Ribosomal_L16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020798">
        <property type="entry name" value="Ribosomal_L16_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12220">
        <property type="entry name" value="PTHR12220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00060">
        <property type="entry name" value="RIBOSOMALL16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="SSF54686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01164">
        <property type="entry name" value="rplP_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00586">
        <property type="entry name" value="RIBOSOMAL_L16_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00701">
        <property type="entry name" value="RIBOSOMAL_L16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000251637" description="50S ribosomal protein L16">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01342"/>
        </source>
    </evidence>
    <sequence length="140" mass="15742" checksum="8B5BC45DB31859A4" modified="2005-11-22" version="1">MLMPKRVKYRKQMKGRMTGAAMRGATLSYGDFGLQATECGWVDSRQIEAARIAMTRYIKRGGKIWIRMFPDKPLTSKPAETRMGKGKGSPDSWVCVVKPGKVLYEMEGVSEEIAREAFRLAANKLPVGTKFISRKEGYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y56</accession>
    <name>Q39Y56_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512272.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0575"/>
    <dbReference type="EnsemblBacteria" id="ABB30818">
        <property type="protein sequence ID" value="ABB30818"/>
        <property type="gene ID" value="Gmet_0575"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0575"/>
    <dbReference type="eggNOG" id="COG3880">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013249_0_0_7"/>
    <dbReference type="OMA" id="NGGSCIC"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010176">
        <property type="entry name" value="C4xCH_C2xCH_motif_GEOSU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09698">
        <property type="entry name" value="GSu_C4xC__C2xCH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01904">
        <property type="entry name" value="GSu_C4xC__C2xCH"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223431" evidence="1">
        <location>
            <begin position="25"/>
            <end position="1127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1127" mass="116303" checksum="C01F4DDEF41D61EE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YC9</accession>
    <name>Q39YC9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein DedA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512198.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0502"/>
    <dbReference type="EnsemblBacteria" id="ABB30745">
        <property type="protein sequence ID" value="ABB30745"/>
        <property type="gene ID" value="Gmet_0502"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0502"/>
    <dbReference type="eggNOG" id="COG0586">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044208_1_1_7"/>
    <dbReference type="OMA" id="SNARFQF"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="207" mass="23341" checksum="476C575E2D283E53" modified="2005-11-22" version="1">MQQIIDWLLATIGTMGYPGIFILMAMESSVIPIPSELVMPPAGYLAQQGEMNIWVAILLGTVGSLVGAYVNYFAAHWLGRPLLLKYGKYVWITEEKFAKVETFFHKHGEISTFIGRLLPVIRHLISLPAGLAGMHHGKFAFYTVAGAFFWVTILTWIGYVIGENRELIMKYSHQALIGVIIFCVVLVVVYVRRHRRKSLSTDAARER</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YE5</accession>
    <name>COBD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin biosynthesis protein CobD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobD</name>
        <name type="ordered locus">Gmet_0486</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobD/CbiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513855.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YE5"/>
    <dbReference type="STRING" id="269799.Gmet_0486"/>
    <dbReference type="EnsemblBacteria" id="ABB30729">
        <property type="protein sequence ID" value="ABB30729"/>
        <property type="gene ID" value="Gmet_0486"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0486"/>
    <dbReference type="eggNOG" id="COG1270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054212_0_0_7"/>
    <dbReference type="OMA" id="WGYRNER"/>
    <dbReference type="OrthoDB" id="2029688at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00024">
        <property type="entry name" value="CobD_CbiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004485">
        <property type="entry name" value="Cobalamin_biosynth_CobD/CbiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34308">
        <property type="entry name" value="PTHR34308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03186">
        <property type="entry name" value="CobD_Cbib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00380">
        <property type="entry name" value="cobD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000201947" description="Cobalamin biosynthesis protein CobD">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00024"/>
        </source>
    </evidence>
    <sequence length="318" mass="33442" checksum="22496DB9867AA11A" modified="2005-11-22" version="1">MTEAGAVVLTAVLLDLLFGDPRWLPHPVVAIGKLITVLEKFLRRLVTNERVGGVLLLLLAVGITAGAAWGAVRGASLVHPLAGVVVSALLGWTCLAARSLHGESKRVADALVRGDLPEARRYLSFIVGRDTAGLSEPEVWRGAVETVAENTSDGVIAPLLFFMIGGAPLALAYKAVNTLDSMVGYKNERYLHFGWASARSDDLANLIPARLTGLLMTLAAPLAGLSGRGAWRIMLRDGRNHSSPNSGIPEAAAAGALGVQLGGTNVYFGKPVAKPTIGDPLKPLDATAWRGTVRLMYGAECLLVLLAAVMTTILTITD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YF2</accession>
    <name>Q39YF2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513848.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0479"/>
    <dbReference type="EnsemblBacteria" id="ABB30722">
        <property type="protein sequence ID" value="ABB30722"/>
        <property type="gene ID" value="Gmet_0479"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0479"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_4_1_7"/>
    <dbReference type="OMA" id="RRWRIRE"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="15"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="105" mass="12298" checksum="ED69E2F6572A2874" modified="2005-11-22" version="1">MTEPRIHIPRDRIIEFCQRWKITEFSLFGSVLRDDFRPDSDVDVLISFAPDAAWTLLDHVDMQDELQTIFGRSVDLVSRKGIERSRNEVRRKAILESAEIFYEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YH5</accession>
    <name>Q39YH5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase and SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513824.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0456"/>
    <dbReference type="EnsemblBacteria" id="ABB30699">
        <property type="protein sequence ID" value="ABB30699"/>
        <property type="gene ID" value="Gmet_0456"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0456"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_415521_0_0_7"/>
    <dbReference type="OrthoDB" id="387524at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024542">
        <property type="entry name" value="DUF3880"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12996">
        <property type="entry name" value="DUF3880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF3880" evidence="1">
        <location>
            <begin position="99"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="672" mass="77235" checksum="A986BA27C3B8F5B2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YJ3</accession>
    <name>Q39YJ3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Flagellar hook-associated protein 1</fullName>
            <shortName evidence="7">HAP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">flgK</name>
        <name evidence="10" type="ordered locus">Gmet_0438</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 7">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512410.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0438"/>
    <dbReference type="EnsemblBacteria" id="ABB30681">
        <property type="protein sequence ID" value="ABB30681"/>
        <property type="gene ID" value="Gmet_0438"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0438"/>
    <dbReference type="eggNOG" id="COG1256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012762_1_0_7"/>
    <dbReference type="OMA" id="WMSSAET"/>
    <dbReference type="OrthoDB" id="1815809at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002371">
        <property type="entry name" value="FlgK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30033">
        <property type="entry name" value="PTHR30033"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01005">
        <property type="entry name" value="FLGHOOKAP1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02492">
        <property type="entry name" value="flgK_ends"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="8">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="9">
        <location>
            <begin position="419"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="477" mass="50340" checksum="E91A58557F2ED7A9" modified="2005-11-22" version="1">MAIQSILDIGKSSLIAQRLALEVTSENITNVNTPGYSRQTTVLATGITTMERGFPMGTGVKVADIQRAYDAFLQSQLSKENTDNGFGTAVLSSMKRTEQLFNDLTTDGLGKAMQNFFNAWQDLTANPQGQPERQAVLSMGQQLVDQFQRINGYLNDVKNEANKSLEGLTSDVNDKIGQIASLNDQIKQIEIQGGHANELRDQRDLLVRQLSSKVGITYVENGDGTLSVSLTLGQPLVIGDKAAKLSLEPDPGNSSYYKIMATSPGGNTAVDISTIAGGPGNAQGEMGGALQVRDTLINGFLSDLDELAYNLANEVNSVHSASYGLTGTTGLNFFNPPAAMAGYSGKGGISLAISKTSDVAAADSDPLTGGTGNNKSASSIASIYDKVLATSGGNLTLEGFFNSLVGKVGVSVQDATRRADQSGGILKQLDNLRESNSGVSLDEELANLVKYQKAYEGAAKLINVGSDMMDTILGLIR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YL8</accession>
    <name>MURC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramate--L-alanine ligase</fullName>
            <ecNumber evidence="1">6.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanine synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murC</name>
        <name type="ordered locus">Gmet_0413</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-alanine + UDP-N-acetyl-alpha-D-muramate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine</text>
            <dbReference type="Rhea" id="RHEA:23372"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512385.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YL8"/>
    <dbReference type="SMR" id="Q39YL8"/>
    <dbReference type="STRING" id="269799.Gmet_0413"/>
    <dbReference type="PRIDE" id="Q39YL8"/>
    <dbReference type="EnsemblBacteria" id="ABB30656">
        <property type="protein sequence ID" value="ABB30656"/>
        <property type="gene ID" value="Gmet_0413"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0413"/>
    <dbReference type="eggNOG" id="COG0773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028104_2_1_7"/>
    <dbReference type="OMA" id="DITYQLR"/>
    <dbReference type="OrthoDB" id="307881at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008763">
        <property type="term" value="F:UDP-N-acetylmuramate-L-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00046">
        <property type="entry name" value="MurC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005758">
        <property type="entry name" value="UDP-N-AcMur_Ala_ligase_MurC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01082">
        <property type="entry name" value="murC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000242558" description="UDP-N-acetylmuramate--L-alanine ligase">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00046"/>
        </source>
    </evidence>
    <sequence length="461" mass="50012" checksum="727DA97B12BC5DB5" modified="2005-11-22" version="1">MYGKIEKIHFVGIGGIGMSGIAEVLLNLGYKVSGSDLKQSDTTDRLASLGGDIRFGHARENLADVDVVVTSTAVHDDNPEVMEAKRRMIPVIPRAEMLAELMRMKYGIAIAGTHGKTTTTSMVATALTHGGIDPTIVIGGKLNTLGTNAKLGQGQFLVAEADESDGSFLKLSPTIAVVTNIDADHLDFYTGGIEQIKDTFVDFINKIPFYGLAVLCLEDRNIAEILPRVKKRFVTYGLSSQADIRATHIRLEGGTTSFVAHYKGYRMGEVSFAMPGAHNVLNALACIAVAMELDVPFAQIQEGFAKFGGVGRRFQVKGEVNGITVVDDYGHHPAEIRATLAAGKSGWPDRRLVVAFQPHRFSRTKELFAEFVTCFYDADVLVLTDIYSAGEAPIEGVTAERLAENIRKHGQRDVTYIADREALPDHLLQIVRPGDIVLTLGAGNIWQTGEALLRKLETAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YQ8</accession>
    <name>Q39YQ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ech-hydrogenase-related complex, HyfE-like integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ehrC-2</name>
        <name evidence="7" type="ordered locus">Gmet_0373</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512345.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0373"/>
    <dbReference type="EnsemblBacteria" id="ABB30616">
        <property type="protein sequence ID" value="ABB30616"/>
        <property type="gene ID" value="Gmet_0373"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0373"/>
    <dbReference type="eggNOG" id="COG4237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088957_1_0_7"/>
    <dbReference type="OMA" id="IFFDLLM"/>
    <dbReference type="OrthoDB" id="1806321at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038730">
        <property type="entry name" value="HyfE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38601">
        <property type="entry name" value="PTHR38601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="212" mass="22811" checksum="3318DC71F31150F0" modified="2005-11-22" version="1">MTSLVDQLIVLVMLINFAALGSGRLAVAIRAVAIQGVILGILPILVHSFSWHLVVITGGLILAKGIIIPWLLTGAIVRARISREMEPYLGYVPTLLIGAITTGLSFVFAARLPLAPEHQGLLFVPAAIATLLTGFIVLVTRRKAISQVIGYLMLENGIFLFGLLLTEAMPVMVEAGVLLDLIVGIFVMGIIINQISREFSSIDTSRLTTLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YX8</accession>
    <name>Q39YX8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">moaA-1</name>
        <name evidence="12" type="synonym">moaA</name>
        <name evidence="14" type="ordered locus">Gmet_0301</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514012.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0301"/>
    <dbReference type="EnsemblBacteria" id="ABB30546">
        <property type="protein sequence ID" value="ABB30546"/>
        <property type="gene ID" value="Gmet_0301"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0301"/>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_7"/>
    <dbReference type="OMA" id="TYCMSEN"/>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="6"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="326" mass="35678" checksum="D9B196073A1882D6" modified="2005-11-22" version="1">MKLVDSHGRRINYLRLSVTDRCNLRCRYCMPAEGVEMLSHGEILSYEELSRIARAAVAIGIEKIRITGGEPLVRRGIVPFLAGIAALPGLRQLVLTTNGILLPEMAADLRRAGVQRLNISLDSLKPETFRDITRTGNVERVLAGIDAAVVAGFPPPKINMVVMRGVNDDEVVDFARLTLDHPYTVRFIEYMPATREENWQRLCIPAQEVLDRIAASHELEPVERGAMAGPSRDFRIRGAVGTIGVISAVSGHFCGECNRIRVTSTGMAKSCLFSDEGLDLKPFLGENAPPVLEDALRRLVGCKPARHGMDGEKVEHAAFSMAKVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z28</accession>
    <name>Q39Z28_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">coxD</name>
        <name evidence="7" type="ordered locus">Gmet_0251</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513567.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0251"/>
    <dbReference type="EnsemblBacteria" id="ABB30496">
        <property type="protein sequence ID" value="ABB30496"/>
        <property type="gene ID" value="Gmet_0251"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0251"/>
    <dbReference type="HOGENOM" id="CLU_146734_3_0_7"/>
    <dbReference type="OMA" id="IAFFMHM"/>
    <dbReference type="OrthoDB" id="2078768at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011743">
        <property type="entry name" value="Caa3_sub_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005171">
        <property type="entry name" value="Cyt_c_oxidase_su4_prok"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03626">
        <property type="entry name" value="COX4_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02229">
        <property type="entry name" value="caa3_sub_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="98" mass="10732" checksum="1A696F41D9132C7F" modified="2005-11-22" version="1">MGSDTHDTTTHVIGYKTLTTVWIALLALTALTVWVALNAPGIGHVWGSLAIAAAKGGLVIAFFMHMRYEGRLLRWLLFVALVTLAIFIGLTFSDVLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z89</accession>
    <name>Q39Z89_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="4 12">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">hemB</name>
        <name evidence="14" type="ordered locus">Gmet_0189</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>2 5-aminolevulinate = H(+) + 2 H2O + porphobilinogen</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the ALAD family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="4 12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512778.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0189"/>
    <dbReference type="EnsemblBacteria" id="ABB30435">
        <property type="protein sequence ID" value="ABB30435"/>
        <property type="gene ID" value="Gmet_0189"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0189"/>
    <dbReference type="eggNOG" id="COG0113">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035731_0_0_7"/>
    <dbReference type="OMA" id="YQMDYAN"/>
    <dbReference type="OrthoDB" id="677575at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="PTHR11458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="9">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="325" mass="36333" checksum="0C7EBCA2AD51F5A5" modified="2005-11-22" version="1">MFFPTFRARRIRGKEVFRRMVSETTLSATDLIYPMFSAFGTGIRKEISSMPGIYQQSIEHIVAEAQEVYELGVPAVILFGIPETKDAVGSDAYDEHGIIQETIRAIKKQVPGLAVITDVCMCEYTDHGHCGIIKDGDVDNDETLELLAKEALSHAEAGADMVAPSDMMDGRVMAIREILDNHGYKHIPIMSYAVKYASGYYGPFREAAESTPQFGDRRSYQMDPGNRREAVREARMDVEEGADIIMVKPGLPYLDIVRDLREEFDLPVAVYNVSGEYSMIKAAGRAGWIDEERVMMETLLSFKRAGADLILTYHAKEAARVLKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z98</accession>
    <name>Q39Z98_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dehydratase, NodN/MaoC domain-containing, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512767.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0180"/>
    <dbReference type="EnsemblBacteria" id="ABB30426">
        <property type="protein sequence ID" value="ABB30426"/>
        <property type="gene ID" value="Gmet_0180"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0180"/>
    <dbReference type="eggNOG" id="COG2030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108911_0_0_7"/>
    <dbReference type="OMA" id="TVDQTMI"/>
    <dbReference type="OrthoDB" id="1380653at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd03450">
        <property type="entry name" value="NodN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039375">
        <property type="entry name" value="NodN-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MaoC-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="158" mass="17533" checksum="6BDACEC50B81064A" modified="2005-11-22" version="1">MSAADELIAFLAPKLGTEIHVGPWLVMEQARIDAFAAATADVQWIHTDPERARSESPYGTTIAHGFLTLSLLPFLTEANAPGQFERNYPGMRLRVNYGLNRVRFPAPVKTGLRIRARTRLTALEPLGSAVQITYEITVEIEGEPKPACVAEQLFRLYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZE0</accession>
    <name>Q39ZE0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phosphoglucomutase/phosphomannomutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_0135</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512720.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0135"/>
    <dbReference type="EnsemblBacteria" id="ABB30384">
        <property type="protein sequence ID" value="ABB30384"/>
        <property type="gene ID" value="Gmet_0135"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0135"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_7"/>
    <dbReference type="OMA" id="DTRFMSE"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="9">
        <location>
            <begin position="3"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="10">
        <location>
            <begin position="166"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="11">
        <location>
            <begin position="267"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="8">
        <location>
            <begin position="415"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB30384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="469" mass="50705" checksum="5D4A37F2673D0723" modified="2005-11-22" version="1">MQIKFGTDGWRGVIARDFTFDNLSRVAQATMEYLIREGLAPRGLVIGYDRRFLSREFAERVAEIAAGNGIRVWLTAGYAPTPAVSWAVHELGAGGGVMITASHNPPAYNGFKVKESFGGSARPSTTKILEEMVAANDAAGREIKARPLAEALADGSVATFDPKGGYFRQLARYVDLEAIRKANLPVVVDPMFGAGAGFVPELLPGVREIHGDENPSFGGQPPEPTEEHLTELAALVASGRYRIGLALDGDADRIGAVDETGEFFSSHRIFTVILRHLVERKGLTGGVVKTVSTTRMVDLLAEKFGLPLHETPIGFKHICELMLDHDILMGGEESGGLGVKGHIPERDGILMGLLLLEAMAVSGKGVRQLLDETMDEIGRFCYRRIDLPIADAAKELLIARLKQGGIASIAGRNVARENFRDGFKFIFEDGSWLLIRPSGTEPVLRLYSEAGDAQTVEELLAAAREIAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZG4</accession>
    <name>Q39ZG4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GspIIEN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514116.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0111"/>
    <dbReference type="EnsemblBacteria" id="ABB30360">
        <property type="protein sequence ID" value="ABB30360"/>
        <property type="gene ID" value="Gmet_0111"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0111"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032809_0_0_7"/>
    <dbReference type="OMA" id="PEFRMNQ"/>
    <dbReference type="OrthoDB" id="1277557at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SSE_N" evidence="1">
        <location>
            <begin position="38"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="370" mass="40510" checksum="0DD319217501C96A" modified="2005-11-22" version="1">MALRLGEMLVKTGRITPDQLDEALRSQVIFGGRLGTNLVEMGCIDEEELARVLSEKLRVPCVDPDELMNISPAIIEAVPLEVVEQYQVVPLRLENRRLFLVMADPSDLPAIDQIAFRTGHVIVPLVAPEIRLLMALEKYYGIKRELRYLPVSKGLGGRRVCSYQPKPADAAIAAPREVVDFSTLPAEGEEFFPWGEGGYDATRIEAAKRHTIDTLSRELVDAPDRDAVARAILNYVGQEFGRAALLLVTRDAVAGWMALDGGNPVPRFDELRIGLDEPSVMLSVTKARVLYHGPVAGTPANLRLLKALGGDKPEGMILVPLVMNKRVVAILCAVGGVELLGARQESLQVVARKGVLAFEVLILKNKILMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZM1</accession>
    <name>Q39ZM1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514178.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30303">
        <property type="protein sequence ID" value="ABB30303"/>
        <property type="gene ID" value="Gmet_0054"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0054"/>
    <dbReference type="HOGENOM" id="CLU_2787955_0_0_7"/>
    <dbReference type="OrthoDB" id="2080582at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="68" mass="7801" checksum="A5C57F19263CC180" modified="2005-11-22" version="1">MDLTLDEHRLISEFRRLNPAGKQEILDLASLLLKRQDEGATASATRDSCTLDRKEERPETTKEPLFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZQ3</accession>
    <name>Q39ZQ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, AAA_5 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513787.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0021"/>
    <dbReference type="DNASU" id="3739923"/>
    <dbReference type="EnsemblBacteria" id="ABB30271">
        <property type="protein sequence ID" value="ABB30271"/>
        <property type="gene ID" value="Gmet_0021"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0021"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_939001_0_0_7"/>
    <dbReference type="OMA" id="NEKSWAS"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="48"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="272" mass="30345" checksum="4016744ABC318894" modified="2005-11-22" version="1">MEQTTIDGIALTLAGPVQLPLKWVGQDELLQQLLAAWMVIDDRDIPFSPRLIGKPGVGKTTLAYAAARRLGRPVYLFQATMDTRPEDLIITPVIGPDGKIQYAASSLVSAMVKGGVLILDEGNRMSEKAWASLAPLLDDRRYVESIITGLRVPAHRDFRIVVTMNEDASTFEVPEYIHSRLQPQIFIDFPEADEELMILKENLPFAPTRILKYVVDFLQRAHAADELYSVRDGINIARYALKMMAATERDAAELLPLAVERVLGDEALRYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-06-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>J7M0B9</accession>
    <name>J7M0B9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3637</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512628.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFR42852">
        <property type="protein sequence ID" value="AFR42852"/>
        <property type="gene ID" value="Gmet_3637"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3637"/>
    <dbReference type="HOGENOM" id="CLU_194458_0_0_7"/>
    <dbReference type="OMA" id="AHKKKAH"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003794761" evidence="2">
        <location>
            <begin position="24"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFR42852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="82" mass="8200" checksum="259C795785871B7C" modified="2012-10-31" version="1">MKKVVSSIVAALVAVAFAGAVFAAEPKKEAAPAAAPAAPAAEVKKEEKKPAAKKAKKAKKAKKAVKKEEAKPAEAPAAPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEM5</accession>
    <name>J9JEM5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3589"/>
    <dbReference type="EnsemblBacteria" id="AFR42804">
        <property type="protein sequence ID" value="AFR42804"/>
        <property type="gene ID" value="Gmet_3589"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3589"/>
    <dbReference type="HOGENOM" id="CLU_214865_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003824251" evidence="2">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFR42804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="42" mass="3992" checksum="AB48CE8E03C7A954" modified="2012-10-31" version="1">MNKKWLVMISMVVMACALIAGCGGSSGGSGGGTTGTISGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEN1</accession>
    <name>J9JEN1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3601"/>
    <dbReference type="EnsemblBacteria" id="AFR42819">
        <property type="protein sequence ID" value="AFR42819"/>
        <property type="gene ID" value="Gmet_3601"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3601"/>
    <dbReference type="HOGENOM" id="CLU_3168532_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="47" mass="5216" checksum="83AAC6556262A0F1" modified="2012-10-31" version="1">MIERRKDYQPSKSLASRHDCASPISAEVSTWSASETSRALMTTARMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEP1</accession>
    <name>J9JEP1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFR42844">
        <property type="protein sequence ID" value="AFR42844"/>
        <property type="gene ID" value="Gmet_3626"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3626"/>
    <dbReference type="HOGENOM" id="CLU_694000_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003824164" evidence="1">
        <location>
            <begin position="22"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="397" mass="42860" checksum="EB5D8BF088048FA4" modified="2012-10-31" version="1">MKRVFLAITLVWLVISMSGCGDDHSTPPPTFVSQIPSNPVFDGDIEQTAPNTFAITQGMTAGVQSVFAGIDPVALTEFRAFLDFPLGGTNGVPANAVIDSAFLDIVINSIQPTTGTIPIRIELVSFQPPTLLTTDFDRTIQPPLAFTTIAPPISLADVGRHVSIDVTQLMVEAQRLGLPHFQVRILEDSGGSGTRHPRPHRDFRSHLKPGNPGAAAASNLFLIVQEQKLQLAHDELGKEGRRRGNARYPQRLEPVVVAIDMTEGDVPRLAVLAFCRRQPRPSAEDEDVQERIPHGAIPAMDSPCGLPRREEISHRGLPLFVDENPAVLVVEGGIGEERPLGDVDLHPHKMPVHGGEAPLEESLSLGLFDERGVEPDSHLAGWGPDAVSLLTFPDDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PX8</accession>
    <name>Q39PX8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513648.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3491"/>
    <dbReference type="EnsemblBacteria" id="ABB33696">
        <property type="protein sequence ID" value="ABB33696"/>
        <property type="gene ID" value="Gmet_3491"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3491"/>
    <dbReference type="eggNOG" id="COG5483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077467_0_1_7"/>
    <dbReference type="OMA" id="RHNPQFN"/>
    <dbReference type="OrthoDB" id="1831995at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007438">
        <property type="entry name" value="DUF488"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014519">
        <property type="entry name" value="UCP024492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04343">
        <property type="entry name" value="DUF488"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF024492">
        <property type="entry name" value="UCP024492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="190" mass="21249" checksum="52B4817F2D396A51" modified="2005-11-22" version="1">MQLTIYTVGHSTRSLEEFVVLLRAHGIRQLVDVRTIPRSRHNPQFNRDTLGTFLRNRRIGYRHMKELGGLRHARADSVNMGWRNASFRGFADYMQTPVFAAALEKLIVLASKRPTAIMCAEAVPWRCHRSLIGDALVVRGIEVKDIMGINSVKQHLLTPMARVEGGQVTYPAQGEEDSGVSARGIKTAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q40</accession>
    <name>Q39Q40_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase III subunit gamma/tau</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">dnaX</name>
        <name evidence="7" type="ordered locus">Gmet_3422</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DnaX/STICHEL family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514229.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3422"/>
    <dbReference type="EnsemblBacteria" id="ABB33634">
        <property type="protein sequence ID" value="ABB33634"/>
        <property type="gene ID" value="Gmet_3422"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3422"/>
    <dbReference type="eggNOG" id="COG2812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006229_0_7_7"/>
    <dbReference type="OMA" id="IRENAKY"/>
    <dbReference type="OrthoDB" id="556582at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18137">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022754">
        <property type="entry name" value="DNA_pol_III_gamma-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012763">
        <property type="entry name" value="DNA_pol_III_sug/sutau_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045085">
        <property type="entry name" value="HLD_clamp_pol_III_gamma_tau"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12169">
        <property type="entry name" value="DNA_pol3_gamma3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02397">
        <property type="entry name" value="dnaX_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="6">
        <location>
            <begin position="37"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="394"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="582" mass="63361" checksum="94A8F2187AE18C57" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q87</accession>
    <name>Q39Q87_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3375</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512601.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3375"/>
    <dbReference type="EnsemblBacteria" id="ABB33587">
        <property type="protein sequence ID" value="ABB33587"/>
        <property type="gene ID" value="Gmet_3375"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3375"/>
    <dbReference type="eggNOG" id="COG1547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125317_1_0_7"/>
    <dbReference type="OMA" id="NWRGAVI"/>
    <dbReference type="OrthoDB" id="1858218at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005500">
        <property type="entry name" value="DUF309"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023203">
        <property type="entry name" value="TTHA0068_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34796">
        <property type="entry name" value="PTHR34796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03745">
        <property type="entry name" value="DUF309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140663">
        <property type="entry name" value="SSF140663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="137" mass="15444" checksum="A31B21A3F6CE7863" modified="2005-11-22" version="1">MEKMPETSRACEGSPSGQLLLGIRQFNREEWFECHETLEALWLKERGDVRNFYQGIIQIAIALHHWRNGNLGGSLSLLAGGRGYLLRVPEVCLWVDVAGFIAQADRVISALERLGKEKMGELDPVLIPRLKTVEVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QC3</accession>
    <name>Q39QC3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="synonym">def-1</name>
        <name evidence="3" type="ordered locus">Gmet_3338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512563.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3338"/>
    <dbReference type="EnsemblBacteria" id="ABB33551">
        <property type="protein sequence ID" value="ABB33551"/>
        <property type="gene ID" value="Gmet_3338"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3338"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_2_1_7"/>
    <dbReference type="OMA" id="VCIQHEI"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="167" mass="18884" checksum="F88D11A50D67E635" modified="2005-11-22" version="1">MVRTILTYPNPILKKKAVPVAVINDATRELVRDMAETMYDAQGVGLAAPQIGVSQRVIVIDVSQREERPELIVCINPVFVHTEGESYEEEGCLSVPKYSANVHRHAKVVVKALNLDGEEVTYRAEGLLAIAFQHEIDHLEGMLFVDHLSPLKREMFKKKYRRMVEEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QC5</accession>
    <name>TTCA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-cytidine(32) 2-sulfurtransferase</fullName>
            <ecNumber evidence="1">2.8.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Two-thiocytidine biosynthesis protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA 2-thiocytidine biosynthesis protein TtcA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ttcA</name>
        <name type="ordered locus">Gmet_3336</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine/cysteine desulfurase (IscS) system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AH2 + ATP + cytidine(32) in tRNA + S-sulfanyl-L-cysteinyl-[cysteine desulfurase] = 2-thiocytidine(32) in tRNA + A + AMP + diphosphate + H(+) + L-cysteinyl-[cysteine desulfurase]</text>
            <dbReference type="Rhea" id="RHEA:57048"/>
            <dbReference type="Rhea" id="RHEA-COMP:10288"/>
            <dbReference type="Rhea" id="RHEA-COMP:12157"/>
            <dbReference type="Rhea" id="RHEA-COMP:12158"/>
            <dbReference type="Rhea" id="RHEA-COMP:14821"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61963"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:141453"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:57049"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit. The cluster is chelated by three Cys residues, the fourth Fe has a free coordination site that may bind a sulfur atom transferred from the persulfide of IscS.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The thiolation reaction likely consists of two steps: a first activation step by ATP to form an adenylated intermediate of the target base of tRNA, and a second nucleophilic substitution step of the sulfur (S) atom supplied by the hydrosulfide attached to the Fe-S cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TtcA family.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33549.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512561.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QC5"/>
    <dbReference type="SMR" id="Q39QC5"/>
    <dbReference type="STRING" id="269799.Gmet_3336"/>
    <dbReference type="EnsemblBacteria" id="ABB33549">
        <property type="protein sequence ID" value="ABB33549"/>
        <property type="gene ID" value="Gmet_3336"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3336"/>
    <dbReference type="eggNOG" id="COG0037">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026481_0_0_7"/>
    <dbReference type="OMA" id="MNLDQKQ"/>
    <dbReference type="OrthoDB" id="1051352at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01850">
        <property type="entry name" value="TtcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012089">
        <property type="entry name" value="tRNA_Cyd_32_2_STrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000348744" description="tRNA-cytidine(32) 2-sulfurtransferase">
        <location>
            <begin position="1"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="PP-loop motif" evidence="1">
        <location>
            <begin position="37"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01850"/>
        </source>
    </evidence>
    <sequence length="257" mass="29139" checksum="B31CAF86DAB1BEE7" modified="2013-07-24" version="2">MEFVDEKRYRKIKNGVGRAVADFNLIEEGDRIAVAVSGGKDSYTLLHILEALRRRAPVKYDLVAFTIDSGYPGFRSDVIAAHLKEHGFSHHVEATTHYDIIKEKRRPGSSYCSICARLKRGVLYTLAQQHGCNKLALGHHLDDFVETLLLNQFFVGTLKAMAPRMLADNGATTVIRPLVYVEEREIIPFARENSFPVVCCCCPVCGKADIQRKRMKELLKELERENPAVKRSLLRALANVQPRHLLDRELQRVCEVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QE8</accession>
    <name>Q39QE8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion system protein TssF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tssF</name>
        <name evidence="1" type="ordered locus">Gmet_3313</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512537.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3313"/>
    <dbReference type="EnsemblBacteria" id="ABB33526">
        <property type="protein sequence ID" value="ABB33526"/>
        <property type="gene ID" value="Gmet_3313"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3313"/>
    <dbReference type="eggNOG" id="COG3519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028593_2_1_7"/>
    <dbReference type="OMA" id="VPSMTIM"/>
    <dbReference type="OrthoDB" id="140284at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010272">
        <property type="entry name" value="T6SS_TssF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35370">
        <property type="entry name" value="PTHR35370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05947">
        <property type="entry name" value="T6SS_TssF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028304">
        <property type="entry name" value="UCP028304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03359">
        <property type="entry name" value="VI_chp_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="576" mass="63360" checksum="650CD07297C2CB6C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QH6</accession>
    <name>Q39QH6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54-dependent sensor transcriptional regulator, PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_3285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3285"/>
    <dbReference type="EnsemblBacteria" id="ABB33498">
        <property type="protein sequence ID" value="ABB33498"/>
        <property type="gene ID" value="Gmet_3285"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3285"/>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_8_1_7"/>
    <dbReference type="OMA" id="CLDEREY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="154"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="281"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="609" mass="66977" checksum="EB999745ECA2CD60" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QJ0</accession>
    <name>Q39QJ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CheR-related putative SAM-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512708.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3271"/>
    <dbReference type="EnsemblBacteria" id="ABB33484">
        <property type="protein sequence ID" value="ABB33484"/>
        <property type="gene ID" value="Gmet_3271"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3271"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762387_0_0_7"/>
    <dbReference type="OMA" id="DRFHAGW"/>
    <dbReference type="OrthoDB" id="1462276at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheR" evidence="2">
        <location>
            <begin position="186"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="363" mass="40182" checksum="B6762D4FAD43B21E" modified="2005-11-22" version="1">MKNPHHLPRPHPPACIRPVTDPDETQKALRRLLVPGVLDDHDLQQHITRLGERFRVYAGTVPFGLWGEGLAITAEMRATTDLLLPLKEVRRAFRLLLRRALPFAPDIGGTPLQTAPSWPDCLERLDPPFREPNPARLLAKLADDAEFRTRCIFSLFVPRRHGANADRYPAQGDFLRQWLVTRGRRFDKRLRCLDAACGAGEGTYGLARLLAETGLEPYGFRIVGASRDPLEIFAAAHGFFPHDPPRQEAFRLLRDELRPTGALGRIRFIAADLTADAGGTETFDVILCNGILGGPFMHERRILERVVAGLANRLARGGIILAADRFHDGWKRIVPPELLVEILTGKGLSVVTAGEGIAGIRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QS4</accession>
    <name>Q39QS4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="2">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_3187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512625.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3187"/>
    <dbReference type="EnsemblBacteria" id="ABB33400">
        <property type="protein sequence ID" value="ABB33400"/>
        <property type="gene ID" value="Gmet_3187"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3187"/>
    <dbReference type="eggNOG" id="COG0417">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000203_6_1_7"/>
    <dbReference type="OMA" id="SHEPKNY"/>
    <dbReference type="OrthoDB" id="261704at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol_B_exo1" evidence="7">
        <location>
            <begin position="138"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_pol_B" evidence="6">
        <location>
            <begin position="430"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="744" mass="84355" checksum="E4EBE2189B9A1BEB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QU3</accession>
    <name>Q39QU3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3168</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513884.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33381">
        <property type="protein sequence ID" value="ABB33381"/>
        <property type="gene ID" value="Gmet_3168"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3168"/>
    <dbReference type="HOGENOM" id="CLU_1728764_0_0_7"/>
    <dbReference type="OMA" id="YPIFRFA"/>
    <dbReference type="OrthoDB" id="1645591at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="151" mass="17161" checksum="33CB33ED96781B63" modified="2005-11-22" version="1">MAQTFDFTRLRKLTVIHGFVQVFLLILLAGMSFVLLGKVPSQVFMNSIIRVVVIQLILFYPVYKFALGDARREVSSAAAGLTADEQQALRRKRVFSDILKGALIIFFFTFTLRAPSAPQIQFMILAVFLLSYLTYFQCFNYAAKKLMKAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QU5</accession>
    <name>Q39QU5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ppcB</name>
        <name evidence="3" type="ordered locus">Gmet_3166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513882.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3166"/>
    <dbReference type="EnsemblBacteria" id="ABB33379">
        <property type="protein sequence ID" value="ABB33379"/>
        <property type="gene ID" value="Gmet_3166"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3166"/>
    <dbReference type="HOGENOM" id="CLU_188310_0_0_7"/>
    <dbReference type="OMA" id="CKACHEK"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002322">
        <property type="entry name" value="Cyt_c_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00609">
        <property type="entry name" value="CYTOCHROMEC3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004222997" evidence="1">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="33"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="90" mass="9491" checksum="51CEC64751C2462B" modified="2005-11-22" version="1">MKQLIAAVALTIFAAGAAMAADTLTFPAKNGNVSFGHKKHQQVAGSCKACHEKAPGKIEGFGKDWAHKTCKGCHEQKKAGPTKCGECHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QY9</accession>
    <name>Q39QY9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hemerythrin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3121</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the hemerythrin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514296.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3121"/>
    <dbReference type="EnsemblBacteria" id="ABB33335">
        <property type="protein sequence ID" value="ABB33335"/>
        <property type="gene ID" value="Gmet_3121"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3121"/>
    <dbReference type="eggNOG" id="COG2703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086902_3_1_7"/>
    <dbReference type="OMA" id="AKHFKHE"/>
    <dbReference type="OrthoDB" id="1991725at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12107">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016131">
        <property type="entry name" value="Haemerythrin_Fe_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035938">
        <property type="entry name" value="Hemerythrin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012827">
        <property type="entry name" value="Hemerythrin_metal-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47188">
        <property type="entry name" value="SSF47188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02481">
        <property type="entry name" value="hemeryth_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00550">
        <property type="entry name" value="HEMERYTHRINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="14"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="135" mass="15475" checksum="D18BB0161A8715A6" modified="2005-11-22" version="1">MALITWNDSLSVKVKQFDDQHKKLVEMLNQLFDAMKAGKGSLVVGDILKQLIAYTQTHFAAEERLMTQYGYADLEIHKKEHNALVVQVLDLQKQFQDGKAVLTQNVMTFLRDWLSKHIQGDDKKYGVFFNGKGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R15</accession>
    <name>Q39R15_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Flagellar biosynthetic protein FliR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fliR</name>
        <name evidence="11" type="ordered locus">Gmet_3095</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the FliR/MopE/SpaR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514549.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3095"/>
    <dbReference type="EnsemblBacteria" id="ABB33309">
        <property type="protein sequence ID" value="ABB33309"/>
        <property type="gene ID" value="Gmet_3095"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3095"/>
    <dbReference type="eggNOG" id="COG1684">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063626_2_2_7"/>
    <dbReference type="OMA" id="APQFNIF"/>
    <dbReference type="OrthoDB" id="1942709at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006303">
        <property type="entry name" value="FliR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002010">
        <property type="entry name" value="T3SS_IM_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30065">
        <property type="entry name" value="PTHR30065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01311">
        <property type="entry name" value="Bac_export_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00953">
        <property type="entry name" value="TYPE3IMRPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01400">
        <property type="entry name" value="fliR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="264" mass="28454" checksum="35BE11CE5B99F523" modified="2005-11-22" version="1">MFPLTTPFPSVNDVAFFALVLGRMAGIFAAIPLFGGRRVPMNIKVLAIFALTVVCFPLIKAKIPQLPADMLSLGMLMIREALVGTCLGLLSLIIFAAVEFCGQICGIQMGLSIVSEIDPSRGSQLSIISIFQEMFATLLFLSLNVHHVFINALVESYAVLPVGAWTMSEGLLNFLVVTIGQVFILAIKLSAPIMVTLLLTSVMLGIMARAFPQMNVFFVSMPLNIGIGFIILGLSLTVFLHTLRGSFGALDEQIIALMKLMGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RA8</accession>
    <name>Q39RA8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514492.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3001"/>
    <dbReference type="EnsemblBacteria" id="ABB33216">
        <property type="protein sequence ID" value="ABB33216"/>
        <property type="gene ID" value="Gmet_3001"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3001"/>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140230_5_2_7"/>
    <dbReference type="OMA" id="GNSAKFW"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="23"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="100" mass="11531" checksum="1EAA3EEDE646A422" modified="2005-11-22" version="1">MSKRDFPPIHPGEILREEFLVPLGISQYRLAKEIHVPARRINEIVLEKRGISADTALRLGRYFGTTAQFWINLQAHYDLEVARDAEDTLEQEIKPFNKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RE8</accession>
    <name>Q39RE8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NrdH-like redox domain protein, YruB family, DUF4124-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2959</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512894.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2959"/>
    <dbReference type="EnsemblBacteria" id="ABB33176">
        <property type="protein sequence ID" value="ABB33176"/>
        <property type="gene ID" value="Gmet_2959"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2959"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143563_0_0_7"/>
    <dbReference type="OMA" id="RESNIAF"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025392">
        <property type="entry name" value="DUF4124"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13511">
        <property type="entry name" value="DUF4124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223290" evidence="2">
        <location>
            <begin position="22"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4124" evidence="4">
        <location>
            <begin position="12"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="3">
        <location>
            <begin position="94"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="168" mass="18357" checksum="88D9BB89E7E84B29" modified="2005-11-22" version="1">MPTRTLLSILILHLSCSLAGAEMYQWVDGKGTVVITDTPPPPSKKRKKVKVYNDGDFAPAPPPQPTPAKRSAKGAAAAEAQPASPKKEHFTGTVEMYVTSWCGYCRRAESYLKSKGIPYVAYDIEKDSAARQRHRELGGNGVPLIIIGSNKMSGFSPETLEYYLNNGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RM9</accession>
    <name>Q39RM9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514608.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2877"/>
    <dbReference type="EnsemblBacteria" id="ABB33095">
        <property type="protein sequence ID" value="ABB33095"/>
        <property type="gene ID" value="Gmet_2877"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2877"/>
    <dbReference type="eggNOG" id="COG5617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008305_0_0_7"/>
    <dbReference type="OMA" id="MPTYQLG"/>
    <dbReference type="OrthoDB" id="946896at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018580">
        <property type="entry name" value="Uncharacterised_YfhO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38454">
        <property type="entry name" value="PTHR38454"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="819" mass="92645" checksum="7FC60DDC593340B2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RN3</accession>
    <name>Q39RN3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF3343 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514604.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2873"/>
    <dbReference type="EnsemblBacteria" id="ABB33091">
        <property type="protein sequence ID" value="ABB33091"/>
        <property type="gene ID" value="Gmet_2873"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2873"/>
    <dbReference type="eggNOG" id="ENOG5033A63">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_167443_3_1_7"/>
    <dbReference type="OMA" id="YVAIFNS"/>
    <dbReference type="OrthoDB" id="1844146at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021778">
        <property type="entry name" value="Se/S_carrier-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11823">
        <property type="entry name" value="DUF3343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3343" evidence="1">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="84" mass="9204" checksum="7D5AAB69F009FF6A" modified="2005-11-22" version="1">MIRDGDCVAIFHSIHRVMKAEKVLKGQGFPILLIPAPRALHADCGLAIRYASADRDAVEEVLAAEGLLPEEIHVKQGEQYLKIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RP7</accession>
    <name>CYSD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sulfate adenylyltransferase subunit 2</fullName>
            <ecNumber evidence="1">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP-sulfurylase small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sulfate adenylate transferase</fullName>
            <shortName evidence="1">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysD</name>
        <name type="ordered locus">Gmet_2859</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer composed of CysD, the smaller subunit, and CysN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PAPS reductase family. CysD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366112.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RP7"/>
    <dbReference type="SMR" id="Q39RP7"/>
    <dbReference type="STRING" id="269799.Gmet_2859"/>
    <dbReference type="EnsemblBacteria" id="ABB33077">
        <property type="protein sequence ID" value="ABB33077"/>
        <property type="gene ID" value="Gmet_2859"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2859"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043026_0_0_7"/>
    <dbReference type="OMA" id="LMIDTGH"/>
    <dbReference type="OrthoDB" id="499077at2"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019419">
        <property type="term" value="P:sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00064">
        <property type="entry name" value="Sulf_adenylyltr_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011784">
        <property type="entry name" value="SO4_adenylTrfase_ssu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002936">
        <property type="entry name" value="CysDAde_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02039">
        <property type="entry name" value="CysD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000008960" description="Sulfate adenylyltransferase subunit 2">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00064"/>
        </source>
    </evidence>
    <sequence length="301" mass="34866" checksum="570DFC80B3A2ABB8" modified="2005-11-22" version="1">MRTTLTHLQQLEAESIHIIREVVAEFANPVMLYSIGKDSAVMLHLARKAFYPAPPPFPLLHVDTTWKFRDMIQFRDRMAAECGFDLIVHVNKEGVEQGISPFTHGSALYTDIMKTEGLKQALDKYRFDAAFGGARRDEEKSRAKERIFSFRSANHRWDPKNQRPELWNLYNTRIKQGESIRVFPLSNWTELDVWQYIHLENIPIVPLYYAAVRPVVERDGMLIMVDDERLELKPGETVQHKSVRFRTLGCYPLTGAVESTADTLPKIIQEMLLTRTSERQGRLIDHDQAGSMEKKKQEGYF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RR3</accession>
    <name>RS18_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsR</name>
        <name type="ordered locus">Gmet_2843</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514573.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RR3"/>
    <dbReference type="SMR" id="Q39RR3"/>
    <dbReference type="STRING" id="269799.Gmet_2843"/>
    <dbReference type="EnsemblBacteria" id="ABB33061">
        <property type="protein sequence ID" value="ABB33061"/>
        <property type="gene ID" value="Gmet_2843"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2843"/>
    <dbReference type="eggNOG" id="COG0238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148710_2_2_7"/>
    <dbReference type="OMA" id="VDKIALY"/>
    <dbReference type="OrthoDB" id="1940575at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00270">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001648">
        <property type="entry name" value="Ribosomal_S18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018275">
        <property type="entry name" value="Ribosomal_S18_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036870">
        <property type="entry name" value="Ribosomal_S18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13479">
        <property type="entry name" value="PTHR13479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01084">
        <property type="entry name" value="Ribosomal_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00974">
        <property type="entry name" value="RIBOSOMALS18"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46911">
        <property type="entry name" value="SSF46911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00165">
        <property type="entry name" value="S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00057">
        <property type="entry name" value="RIBOSOMAL_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000003501" description="30S ribosomal protein S18">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="106" mass="12483" checksum="6F639DCBB62B2886" modified="2005-11-22" version="1">MSEETTVRPERTERSERPERPQYRGNGPRKRRPFQRRKVCRFCADKDLVIDYKDPRVLRSFITERGKIVPRRISGNCSKHQREITEAIKRARNIALIPIASTHVVA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RX3</accession>
    <name>METXA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Homoserine O-acetyltransferase</fullName>
            <shortName evidence="1">HAT</shortName>
            <ecNumber evidence="1">2.3.1.31</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Homoserine transacetylase</fullName>
            <shortName evidence="1">HTA</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metXA</name>
        <name type="ordered locus">Gmet_2783</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine</text>
            <dbReference type="Rhea" id="RHEA:13701"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57716"/>
            <dbReference type="EC" id="2.3.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-acetyl-L-homoserine from L-homoserine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.31" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511679.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RX3"/>
    <dbReference type="SMR" id="Q39RX3"/>
    <dbReference type="STRING" id="269799.Gmet_2783"/>
    <dbReference type="ESTHER" id="geomg-metx">
        <property type="family name" value="Homoserine_transacetylase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33001">
        <property type="protein sequence ID" value="ABB33001"/>
        <property type="gene ID" value="Gmet_2783"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2783"/>
    <dbReference type="eggNOG" id="COG2021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028760_1_2_7"/>
    <dbReference type="OMA" id="TRFCVVS"/>
    <dbReference type="OrthoDB" id="536745at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00074"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="PTHR32268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000231870" description="Homoserine O-acetyltransferase">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="44"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="150"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="345"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00296"/>
        </source>
    </evidence>
    <sequence length="369" mass="41582" checksum="FD25E4D90DD5E104" modified="2005-11-22" version="1">MSVGIVQEQSVTFDTELRLESGRILGPITLAYETYGELNADRSNAILVAHAWTGNAHLAGKNSEEDTKPGWWDAIVGPGRLLDTDRCFVICSNVIGSCYGSTGPASINPKTGKRYNLTFPVITVRDMVRAQALLLDHLGIDRLLTVLGGSMGGMQALEWATQFPDRIRSAIALATTSRPSPQAISLNAVARWAIFNDPTWKKGEYRKNPKDGLALARGIGHITFLSDESMWQKFGRRFNARDGLFDFFGQFEVERYLSYNGYNFVDRFDTNSFLYLAKALDLYDTAWGYESLEEAFSRVKAPIQFFAFTSDWLYPPYQTEEMATILRSLGKPVEYHLIESAYGHDAFLLEHETFAPMVREFLDKVERSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RY9</accession>
    <name>Q39RY9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_2767</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511694.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2767"/>
    <dbReference type="CAZy" id="GT35">
        <property type="family name" value="Glycosyltransferase Family 35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32985">
        <property type="protein sequence ID" value="ABB32985"/>
        <property type="gene ID" value="Gmet_2767"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2767"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_7"/>
    <dbReference type="OMA" id="HCACSVA"/>
    <dbReference type="OrthoDB" id="137158at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="835" mass="93833" checksum="8E4DFC661A9378FC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S56</accession>
    <name>Q39S56_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511761.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2700"/>
    <dbReference type="EnsemblBacteria" id="ABB32918">
        <property type="protein sequence ID" value="ABB32918"/>
        <property type="gene ID" value="Gmet_2700"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2700"/>
    <dbReference type="eggNOG" id="COG3431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134275_0_0_7"/>
    <dbReference type="OMA" id="TEVMAFW"/>
    <dbReference type="OrthoDB" id="1837290at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020948">
        <property type="entry name" value="P_starv_induced_PsiE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06146">
        <property type="entry name" value="PsiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="145" mass="16648" checksum="47DED90B91260B29" modified="2005-11-22" version="1">MWKENVIDLKLTRFFEISARALLSLLIFAILLAILAAIIGTFHDLRLVMGHDMHGAFRTILVDVLTVLAIVEVLRTALAYFTEGRVKVTYIIDTVLVTVLTEVMAFWYRDMNWEKITMVIALVLSLAAVRIITVRFSPRRLREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S63</accession>
    <name>Q39S63_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Winged-helix phosphate transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">phoB</name>
        <name evidence="6" type="ordered locus">Gmet_2693</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511768.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2693"/>
    <dbReference type="EnsemblBacteria" id="ABB32911">
        <property type="protein sequence ID" value="ABB32911"/>
        <property type="gene ID" value="Gmet_2693"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2693"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_4_7"/>
    <dbReference type="OMA" id="GYRFRQP"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="3"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="129"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="129"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="226" mass="25216" checksum="25F140236C41903C" modified="2005-11-22" version="1">MQTVLIIEDEKDLAELVSFNLEKEGYRTIAAPDGISGLDEAQRQVPDLILLDLMLPGMMGTEVCKILKKSEKTAKIPVIMLTARGEEIDRVVGFEVGADDYVVKPFSTRELLLRIKAVLRRSLPDEPSGKTMRIGPIAIDPDRHTVAVAGEEIVLTTTEFKLLLNLAERLGRVQSRDLLLKNVWGYNYVGDTRTVDTHITRLRTKLGPAGDLIKTVRGFGYKMEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S83</accession>
    <name>Q39S83_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coenzyme A biosynthesis bifunctional protein CoaBC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DNA/pantothenate metabolism flavoprotein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Phosphopantothenoylcysteine synthetase/decarboxylase</fullName>
            <shortName evidence="3">PPCS-PPCDC</shortName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenoylcysteine decarboxylase</fullName>
                <shortName evidence="3">PPC decarboxylase</shortName>
                <shortName evidence="3">PPC-DC</shortName>
                <ecNumber evidence="3">4.1.1.36</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaC</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Phosphopantothenate--cysteine ligase</fullName>
                <ecNumber evidence="3">6.3.2.5</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">CoaB</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="3">Phosphopantothenoylcysteine synthetase</fullName>
                <shortName evidence="3">PPC synthetase</shortName>
                <shortName evidence="3">PPC-S</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 7" type="primary">coaBC</name>
        <name evidence="7" type="ordered locus">Gmet_2673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="function">
        <text evidence="4">Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-4'-phosphopantothenate + CTP + L-cysteine = CMP + diphosphate + H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:19397"/>
            <dbReference type="ChEBI" id="CHEBI:10986"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="6.3.2.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>H(+) + N-[(R)-4-phosphopantothenoyl]-L-cysteine = (R)-4'-phosphopantetheine + CO2</text>
            <dbReference type="Rhea" id="RHEA:16793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:59458"/>
            <dbReference type="ChEBI" id="CHEBI:61723"/>
            <dbReference type="EC" id="4.1.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="3">Binds 1 FMN per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 2/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the C-terminal section; belongs to the PPC synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.36" evidence="3"/>
    <dbReference type="EC" id="6.3.2.5" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511788.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2673"/>
    <dbReference type="EnsemblBacteria" id="ABB32891">
        <property type="protein sequence ID" value="ABB32891"/>
        <property type="gene ID" value="Gmet_2673"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2673"/>
    <dbReference type="eggNOG" id="COG0452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033319_0_1_7"/>
    <dbReference type="OMA" id="LDMIVAN"/>
    <dbReference type="OrthoDB" id="1346419at2"/>
    <dbReference type="UniPathway" id="UPA00241">
        <property type="reaction ID" value="UER00353"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004632">
        <property type="term" value="F:phosphopantothenate--cysteine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015941">
        <property type="term" value="P:pantothenate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02225">
        <property type="entry name" value="CoaBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005252">
        <property type="entry name" value="CoaBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007085">
        <property type="entry name" value="DNA/pantothenate-metab_flavo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04127">
        <property type="entry name" value="DFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="SSF102645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00521">
        <property type="entry name" value="coaBC_dfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 4" id="KW-0288">FMN</keyword>
    <keyword evidence="3 4 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="5"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="DFP" evidence="6">
        <location>
            <begin position="185"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenoylcysteine decarboxylase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Phosphopantothenate--cysteine ligase" evidence="3">
        <location>
            <begin position="189"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="303"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="403" mass="43182" checksum="B142CF95230A08F0" modified="2005-11-22" version="1">MLNGKQIVLGVTGGIAVYKAVELVRLLTKAGADVHVIMTRSATEFVGPLTFQTLTANPVHTEIFNLIAEREIGHIALADRADLFIIAPATANVIGKIAGGIADDMLTTTVMATRASVLIAPAMNVNMCTNPIYRENEEKLRRHGYRFVAPVKGMLACGWEGEGKLQDPAIIMEEAVCALTRQDLVGERVLVTAGPTLEEIDPVRFISNHSSGKMGYSIARAARRRGAEVVLVAGPTCLDDPWGIETVHVCSAAEMRDAVMERVAASTVIVKAAAVADYCPKSRAAGKIKKSADAMVLELEKNPDILAEVGRVKGDRVLVGFAAETSDLVENARKKLTGKNLDLVVANDIGQPGAGFNVDTNIAKLLHRDGRVEELPLMGKDEMATIILDRAAGLRKQGMRGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S97</accession>
    <name>Q39S97_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2659</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511802.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2659"/>
    <dbReference type="EnsemblBacteria" id="ABB32877">
        <property type="protein sequence ID" value="ABB32877"/>
        <property type="gene ID" value="Gmet_2659"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2659"/>
    <dbReference type="eggNOG" id="ENOG50330XA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_592844_0_0_7"/>
    <dbReference type="OMA" id="AVEGGRM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223220" evidence="3">
        <location>
            <begin position="37"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="461" mass="50595" checksum="A1033341C3ED7FC1" modified="2005-11-22" version="1">MTMGTRFIKVKTLRGRGLLFLAACQFCAAAAFTAEASAGAFDQLRSMTGGGSVYIPPVSGPECVSGCGGSGGDDGGNSGYERGPSLFERINQWQEEREQARQQEERQRKQEAFNLNEQGNRAYEKSDWAKAVELYKNAVGKSPNDKVIQENLRRAEQELKRQEELRKERSEYRQRMGKLVALMPAAKPLSKTVQAPRPVVPLPGFSPQQWQEYLAAQETVAVLYARLNKDGVLSDADAEAFYAALRRRNELWAMAAGQPRSDEERDSLRLPLPRVVSKTLLNSVMGMFQQDSSAANAARTIKSPDRRLASAADSKSQPDDPITTAFAADFFTDKITKIIESETGDAIEEARGEKFKGYYEKMLAVGRIAVKAGEGGAPAAGAETADLIISKIPEPVGPHAEFAVEGGRMYSKVAYQALNRFMVDATAATGTSFDAEGFWKRFNDELSASRKGVKAWIQFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S98</accession>
    <name>Q39S98_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin/PDZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2658</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2658"/>
    <dbReference type="EnsemblBacteria" id="ABB32876">
        <property type="protein sequence ID" value="ABB32876"/>
        <property type="gene ID" value="Gmet_2658"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2658"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_297855_0_0_7"/>
    <dbReference type="OMA" id="MELAYES"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="527"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="3">
        <location>
            <begin position="871"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1003" mass="108568" checksum="03D785CDD994540A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SD7</accession>
    <name>Q39SD7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">6-phosphogluconolactonase</fullName>
            <shortName evidence="7">6PGL</shortName>
            <ecNumber evidence="5 7">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">pgl</name>
        <name evidence="9" type="ordered locus">Gmet_2618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="5 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511843.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2618"/>
    <dbReference type="EnsemblBacteria" id="ABB32837">
        <property type="protein sequence ID" value="ABB32837"/>
        <property type="gene ID" value="Gmet_2618"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2618"/>
    <dbReference type="eggNOG" id="COG0363">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053947_2_0_7"/>
    <dbReference type="OMA" id="YQLFEFE"/>
    <dbReference type="OrthoDB" id="1828393at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="PGLS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="PTHR11054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine_iso" evidence="8">
        <location>
            <begin position="7"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="241" mass="26772" checksum="AC87C0B857667FFE" modified="2005-11-22" version="1">MIRVYLDREALSMAAAELFATAAHSAMRDTGRFAVALAGGDTPRRTYEILAHEPFRKRVPWEKTHVFWGDERCVPAADPRNNARMASRALLDHVLVPDGQVHPMVCGRAPQDAAKEYEALLRSWFPGELPRFDLILLGLGENGHTASLFPETPVLDERRRWVADVSPANDGMHRLTLTVPVINQASRVVFLVSGANKAPILREVLEGSPDPHRIPACLIRPAGQLVWLVDRDAARLLRNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SH2</accession>
    <name>Q39SH2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multicopper oxidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513451.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2583"/>
    <dbReference type="EnsemblBacteria" id="ABB32802">
        <property type="protein sequence ID" value="ABB32802"/>
        <property type="gene ID" value="Gmet_2583"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2583"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009100_4_0_7"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="1">
        <location>
            <begin position="601"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="734" mass="79589" checksum="5D2C15CD50F0FE65" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SI3</accession>
    <name>Q39SI3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513462.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2572"/>
    <dbReference type="DNASU" id="3738876"/>
    <dbReference type="EnsemblBacteria" id="ABB32791">
        <property type="protein sequence ID" value="ABB32791"/>
        <property type="gene ID" value="Gmet_2572"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2572"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_893503_0_0_7"/>
    <dbReference type="OMA" id="YLWSHFA"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="113"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="313" mass="34497" checksum="3B3D086949A8CE90" modified="2005-11-22" version="1">MKRSIAPLLVCPACLPKERPLELTATAEADGDITAGHLSCKGCRRRFPIRDGIAVLLPDPDTGPSGGQWKYEEQGTLATYLWSHFADLAGDPEAGDAYASWASALAGNAETSLDAGCAVGRLTFELGQRSGLAVGFDLSLTFIRAARQLARERQIRFSLPREGNLRDEFRLTLPDCWRTDEVEFVVADALAIPFARETFDRTASLNLIDRVSYPLAHLYEMNRVARLSGASFLLSDPFSWSTANAPEEKWLGGTESGPYSGRGMDNVKAILGGKEAIIAPPWTVAREGSVWWKIRSHRNHFELIRSEFLVAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SL4</accession>
    <name>Q39SL4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter, periplasmic substrate-binding protein, MCE domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513493.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2541"/>
    <dbReference type="DNASU" id="3738826"/>
    <dbReference type="EnsemblBacteria" id="ABB32760">
        <property type="protein sequence ID" value="ABB32760"/>
        <property type="gene ID" value="Gmet_2541"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2541"/>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054524_0_1_7"/>
    <dbReference type="OMA" id="NALKWSD"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="MlaD" evidence="2">
        <location>
            <begin position="47"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="360" mass="39669" checksum="3B3447808C510DC8" modified="2005-11-22" version="1">MKRSDNVSWSQLKGGIFILVALAFFAGGVLLMGDKTKFFVPKGRLSVIMADVAGLKAGAPVWLAGVDVGVVTQIHFERPEATNEVEIVLEVDREALKKIGADSVVTVKTRGLMGEKYVDITPTREIVAKPVTRLQGTPMPKLDDVVQKAGRAFDRVDAIVAKTERGEGTLGRFASDPKLYDSLVRLTTELNAVAVSVNRGEGTLGMLNKSREPYEKLMSILNRADNTLTDIQSSEGTMSKLIHDRELYDKLVAVASKAGTAADEVRELNRRLLSKDGTLGKLVADREFYDRGLTLINRADTSLKSLEEVTARLQRGEGTAGKLLSDRELYDRLNRTVDDLDLLVKDIKENPKRYVKFSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SW1</accession>
    <name>Q39SW1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512462.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2438"/>
    <dbReference type="EnsemblBacteria" id="ABB32663">
        <property type="protein sequence ID" value="ABB32663"/>
        <property type="gene ID" value="Gmet_2438"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2438"/>
    <dbReference type="eggNOG" id="ENOG503001N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_507859_0_0_7"/>
    <dbReference type="OMA" id="LYRVKPY"/>
    <dbReference type="OrthoDB" id="759134at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025388">
        <property type="entry name" value="Alginate_export_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13372">
        <property type="entry name" value="Alginate_exp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223083" evidence="1">
        <location>
            <begin position="23"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Alginate_exp" evidence="2">
        <location>
            <begin position="202"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="534" mass="58947" checksum="B8B36444DA0685C9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SW6</accession>
    <name>KDPA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium-transporting ATPase potassium-binding subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP phosphohydrolase [potassium-transporting] A chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Potassium-binding and translocating subunit A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Potassium-translocating ATPase A chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kdpA</name>
        <name type="ordered locus">Gmet_2433</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the periplasmic potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KdpA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512467.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SW6"/>
    <dbReference type="SMR" id="Q39SW6"/>
    <dbReference type="STRING" id="269799.Gmet_2433"/>
    <dbReference type="EnsemblBacteria" id="ABB32658">
        <property type="protein sequence ID" value="ABB32658"/>
        <property type="gene ID" value="Gmet_2433"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2433"/>
    <dbReference type="eggNOG" id="COG2060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018614_3_0_7"/>
    <dbReference type="OMA" id="RQGWAIL"/>
    <dbReference type="OrthoDB" id="296671at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00275">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004623">
        <property type="entry name" value="KdpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30607">
        <property type="entry name" value="PTHR30607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03814">
        <property type="entry name" value="KdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001294">
        <property type="entry name" value="K_ATPaseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00680">
        <property type="entry name" value="kdpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000022223" description="Potassium-transporting ATPase potassium-binding subunit">
        <location>
            <begin position="1"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="11"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00275"/>
        </source>
    </evidence>
    <sequence length="586" mass="62392" checksum="3051AD3A6B54AA08" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SY3</accession>
    <name>Q39SY3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain iron-sulfur cluster-binding oxidoreductase with cobalamin-binding-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hpnJ</name>
        <name evidence="4" type="ordered locus">Gmet_2416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512484.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2416"/>
    <dbReference type="EnsemblBacteria" id="ABB32641">
        <property type="protein sequence ID" value="ABB32641"/>
        <property type="gene ID" value="Gmet_2416"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2416"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_4_2_7"/>
    <dbReference type="OMA" id="YRQFYFR"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017834">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00404">
        <property type="entry name" value="hopanetetrol_cyclitol_ether_sy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03471">
        <property type="entry name" value="HpnJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="64"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="192"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="475" mass="54207" checksum="20F1FFE17EA0E03C" modified="2005-11-22" version="1">MKPLFLNPPTYEDFDGGAGARYQASREVTSFWYPTWLCFPAGMIDGSRVVDAPVQRFTIDDCLAIARDFDMVVMYTSTPTLALDIATARRVKEQKPATVTVLTGPHVSVLPEETLRQGEGVIDIVCRGEFDYTTKELCEGREWAKVDGISFWKDGKIHHTPDRPPIQDLDALPFVAPVYKRDLPIAEYVIPHFKNPYVSIYSSRGCPSKCIYCLWPQTFSGRAMRTRSPQNVYEEVKWIVDNIPEMRELSFDDDTFTADRKHAREVAAKLKPLGISWTINARANCDYETLKIMREAGLRHVVVGYETGNEQILKNIKKGVTKEQAIEFTRNCKKLGLSVHGAFIMGLPGETRDTIRETIEYAKALDLNSIQASLASPYPGTEFWDLCRQEGWIASEAYIDDTGHQMCVINYPHLSNKEIFDAVELFYNKFYFRPKYIGRSIMKMIVDGEERKKLLKEGKQYLEYMRKRKAAGSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T97</accession>
    <name>Q39T97_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver CheY associated with MCPs of class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY40H-4</name>
        <name evidence="3" type="ordered locus">Gmet_2302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2302"/>
    <dbReference type="EnsemblBacteria" id="ABB32527">
        <property type="protein sequence ID" value="ABB32527"/>
        <property type="gene ID" value="Gmet_2302"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2302"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_12_7"/>
    <dbReference type="OMA" id="AMRRSIM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="7"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="127" mass="13853" checksum="CE0C175B4A3E0069" modified="2005-11-22" version="1">MTMSDKRILVVEDSPTMRQLISFTLRRLPGVALVEATDGVDALKKLGGDSFDLIFTDINMPIMDGLKLVSLVRNDPSLRHIPVVIITTEGAAEDRQRGLALGANDYLTKPIQAGKILAVARELLRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TA4</accession>
    <name>Q39TA4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BFN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514503.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2295"/>
    <dbReference type="EnsemblBacteria" id="ABB32520">
        <property type="protein sequence ID" value="ABB32520"/>
        <property type="gene ID" value="Gmet_2295"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2295"/>
    <dbReference type="eggNOG" id="COG1259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096111_2_2_7"/>
    <dbReference type="OMA" id="LFKNFAD"/>
    <dbReference type="OrthoDB" id="1594801at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036104">
        <property type="entry name" value="BFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003729">
        <property type="entry name" value="Bi_nuclease_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02577">
        <property type="entry name" value="DUF151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103256">
        <property type="entry name" value="SSF103256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51658">
        <property type="entry name" value="BFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BFN" evidence="1">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="166" mass="18275" checksum="8E52CFA63F840D39" modified="2005-11-22" version="1">MYLKMNIHGFALDSIAQRPVVLLKDADEANTIPIWINSSDTLYIVAELVRHDAAAKSDRKDLLSALLGHLDAEVAEIVIEDMKDGLFDASVGVLLDGETVLLPVRIPEALVLALKHSLPVMVADHLLNKIAKSNGDTDERFTDADARRFVDFLENLDPADLGKYPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TA6</accession>
    <name>Q39TA6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 14">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="7">IMP dehydrogenase</shortName>
            <shortName evidence="7">IMPD</shortName>
            <shortName evidence="7">IMPDH</shortName>
            <ecNumber evidence="7 14">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 16" type="primary">guaB</name>
        <name evidence="16" type="ordered locus">Gmet_2293</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 14">
            <text>H2O + IMP + NAD(+) = H(+) + NADH + XMP</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 14">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 13">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="7 14"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514505.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2293"/>
    <dbReference type="EnsemblBacteria" id="ABB32518">
        <property type="protein sequence ID" value="ABB32518"/>
        <property type="gene ID" value="Gmet_2293"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2293"/>
    <dbReference type="eggNOG" id="COG0516">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022552_1_0_7"/>
    <dbReference type="OMA" id="MGYCGAK"/>
    <dbReference type="OrthoDB" id="532857at2"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="PTHR11911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 7 14" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="2 7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="5 7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 7 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 14" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="94"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="15">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="338"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="IMP binding" evidence="7 9">
        <location>
            <begin position="385"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="7 8">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="248"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 10">
        <location>
            <begin position="298"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 11">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB32518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="491" mass="52533" checksum="D306FBF29DB8DA94" modified="2005-11-22" version="1">MLDETIQEGLTFDDVLLVPAHSQVLPRDVSLNTRLTRNIHLNIPLVSAAMDTVTEARTAICMAREGGIGIIHKNLTIEEQAMEVDKVKKSESGMIVDPITMRPNQKIHEALAIMEKYRISGVPVTNAKGKLVGILTNRDLRFETDLNLPISARMTKKRLVTVAVGTTLEEAKEHLKQTRVEKLLVVDDDKNLKGLITIKDIEKVRKYPNACKDGLGRLRVGAAVGPTADMLVRADALVKAGVDVIAIDTAHGHSQGVLDAIRSLKSAFPGVELIAGNIATAEAAEALIKAGVDAIKVGIGPGSICTTRVVAGVGVPQISAIAQCAKVARKYDIPLIADGGVKYSGDVTKAVAAGADVIMIGSLFAGTEESPGDTILYQGRAYKSYRGMGSIGAMKEGSKDRYFQSDVESEVKLVPEGIEGMVPLRGPLGANVHQLMGGLRAGMGYTGCHTVSELQQKGRFIRITGAGLKESHVHDVMITKEAPNYRVENVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TB1</accession>
    <name>Q39TB1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aldolase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514510.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2288"/>
    <dbReference type="EnsemblBacteria" id="ABB32513">
        <property type="protein sequence ID" value="ABB32513"/>
        <property type="gene ID" value="Gmet_2288"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2288"/>
    <dbReference type="eggNOG" id="COG0235">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_713162_0_0_7"/>
    <dbReference type="OMA" id="CREEYFR"/>
    <dbReference type="OrthoDB" id="994813at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="SSF53639"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldolase_II" evidence="1">
        <location>
            <begin position="202"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="391" mass="42142" checksum="D05C960C294EAD88" modified="2005-11-22" version="1">MFDQIAAYTNKLVADRSALPGEIAIAAQDDALIADGYPALAQLAGDVLARLSCLGLIAARPSLPFADFLVARAPRKESFIVPRDTETRTFLHDIPFLRREELGSDPAPAIARLLGSRKGVVVEGMGIVASGALTIEQAYINYSSVFHSTFVKYLQDVLHDGFVLPGEAEAFAAFRRDWLRPLSADGLAFHCGPLADPAVILHEITTVGRYTVERGLVDSFFGNISCRAGDVIYISQTAASLDALAGCIDPVPMDNSSTFGITASSELLAHRRIYEVSGAATILHGHPKFAVVMSMECDEVGCTVTDCWKECDRVRLLGDAPVVAGEIGAGGLAKRVPPVIAGPRRAVVYGHGVFTVGEKDFAEAFRAMVEVENWCREEYFRRVAETLKIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TG4</accession>
    <name>Q39TG4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365988.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2233"/>
    <dbReference type="EnsemblBacteria" id="ABB32460">
        <property type="protein sequence ID" value="ABB32460"/>
        <property type="gene ID" value="Gmet_2233"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2233"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061385_1_0_7"/>
    <dbReference type="OMA" id="GPRYIAY"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07726">
        <property type="entry name" value="ST1585-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037482">
        <property type="entry name" value="ST1585_MBL-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="27"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="316" mass="34565" checksum="AD818C423DD659E4" modified="2005-11-22" version="1">MVSGKVLKEPASGFMFMDTLDRGVKGYAGGWLVRGKRYNCIVETGAGAAVPLWLAGLKQAGIPLESIRWILLTHVHLDHAGGAGELLRHLPNARIGIHPLGVRHILDPQRLLSHAKVVWEKDFDLLGPMLPAPAERVVELGDGEIIEIDDVRRIKVLYTPGHTSHHVAFFEESTRGVFSGDALGAFFRGKHPFGEYVSMPGVSPPKGDIPAYVQSVERIAKLSPRRIYATHFGLWEPAMPYILSATSQIITISDLCRDVFYGGGGLQDFLSRAATLLASVRQSTRGQVELEKNYFSMAKAVWNYVVAEKGGESSPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TG9</accession>
    <name>Q39TG9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2228</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365983.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2228"/>
    <dbReference type="EnsemblBacteria" id="ABB32455">
        <property type="protein sequence ID" value="ABB32455"/>
        <property type="gene ID" value="Gmet_2228"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2228"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_8_0_7"/>
    <dbReference type="OMA" id="DINGANH"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="151" mass="16944" checksum="C652BA671C52E45A" modified="2005-11-22" version="1">MARVQIDLPDKFIYSTKLQVRIGDVAAGFHMGNHMLISYLNEALLLFFREAGVIGMFGTKMNLIDADLAVIYKTEAAHGDMLRVDLGIIPSGIYGFDAFYRVTNERTGEEIAIAKMAMLFFDYEQRQISPVPEAFTVALPKIYNRAIPSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TP1</accession>
    <name>Q39TP1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multicopper oxidase, type 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513051.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2154"/>
    <dbReference type="EnsemblBacteria" id="ABB32383">
        <property type="protein sequence ID" value="ABB32383"/>
        <property type="gene ID" value="Gmet_2154"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2154"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009100_2_1_7"/>
    <dbReference type="OMA" id="PYSGRYV"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="5">
        <location>
            <begin position="90"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="247"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="4">
        <location>
            <begin position="397"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="515" mass="55207" checksum="8AC52F9582594941" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TQ6</accession>
    <name>Q39TQ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">4-hydroxybenzoyl-CoA reductase molybdenum cofactor biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pcmW</name>
        <name evidence="1" type="ordered locus">Gmet_2139</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513066.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2139"/>
    <dbReference type="DNASU" id="3740370"/>
    <dbReference type="EnsemblBacteria" id="ABB32368">
        <property type="protein sequence ID" value="ABB32368"/>
        <property type="gene ID" value="Gmet_2139"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2139"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068045_2_1_7"/>
    <dbReference type="OMA" id="KITPNIC"/>
    <dbReference type="OrthoDB" id="1307994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017587">
        <property type="entry name" value="YqeC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19842">
        <property type="entry name" value="YqeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03172">
        <property type="entry name" value="TIGR03172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="27675" checksum="1CE22DC5EA9F02F8" modified="2005-11-22" version="1">MENFAEIVGIGPAGVISITGGGGKTSLMFHLARQLAYSGKRVLTTTTTKILAPSVEESRTLLISQDPQVILRHAKAHPGPGVHVSAAAGHIPHTEKLQGFPREAIRTFEDSGEFDWVVVEADGAARKPLKAPAAHEPVIPGNSTIVVALAGLEVLGRPLGEEMVFRSELAGELMQIPQGETITVPALARLLAHPSGGFKGAPPQARRFIFLNKADTPELQEKGGEVALQLKEIAPSVAEAVIVGQLRQEITLHRVYPRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TR5</accession>
    <name>Q39TR5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513075.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2130"/>
    <dbReference type="EnsemblBacteria" id="ABB32359">
        <property type="protein sequence ID" value="ABB32359"/>
        <property type="gene ID" value="Gmet_2130"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2130"/>
    <dbReference type="eggNOG" id="COG5015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137964_2_0_7"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="132" mass="15392" checksum="A1FD5BBAA290945C" modified="2005-11-22" version="1">MKEVLDMLPAPCYGSLATVAGGKPRVRPFAFMYEENGRFYFCTASNKEVYRQLTETPFIEFTRTDEQMRWLRIGGEITFDEDIKSREKCFANYPMLKDIYQTPDNPLFKVFYLEHGAASVNSLTEPPKNFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TU7</accession>
    <name>Q39TU7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phosphotransbutyrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ptb</name>
        <name evidence="3" type="ordered locus">Gmet_2098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513106.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2098"/>
    <dbReference type="EnsemblBacteria" id="ABB32327">
        <property type="protein sequence ID" value="ABB32327"/>
        <property type="gene ID" value="Gmet_2098"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2098"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056531_0_0_7"/>
    <dbReference type="OMA" id="CIVDGPF"/>
    <dbReference type="OrthoDB" id="1301815at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTA_PTB" evidence="2">
        <location>
            <begin position="77"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="301" mass="32205" checksum="3729CD6E18692512" modified="2005-11-22" version="1">MIKSFDELIAAVQEKPKKKIAIVSPEGTTVMKLVKQALDAKLAEFILVGDEGKIKTMSAEAGFDSNLINIINIPNQKDAAEEAVRLVVVGSANAIMKGNLPTATFMRAILDKQKGLNDNRVISEITIYEKIVDAPGGGFRFLTDCAINVQPTLDEKKQIIENAVDLAHKLGNTLPKVAVISAVEVVNPAMPDTIEAAALSKMAERGQIEGCLVEGPLAFDNAISQEAAKYKKIKGEVAGQADIIMAPNLLSANPLRKCLVYYTQQRIATAVMGAKAPIVLTSRSDSAETMLLTIALAAYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TY2</accession>
    <name>Q39TY2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514040.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2063"/>
    <dbReference type="EnsemblBacteria" id="ABB32292">
        <property type="protein sequence ID" value="ABB32292"/>
        <property type="gene ID" value="Gmet_2063"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2063"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_884980_0_0_7"/>
    <dbReference type="OrthoDB" id="1786865at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="44"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="314" mass="35038" checksum="6A37F16E797EB5E9" modified="2005-11-22" version="1">MSGTLFTYRRKVDFGDCDSARIYFTPRAVDYAVEAVEAWFGDVLGVSWADLFLRHDLDVTFVRMGCEYFRPVIADQTVHVRVRATAVDRSSVTFSAAGEDDSGGVFFRATLVAQFRAGRNRAPVPIPPRYRERMEDCLEQADGKSGTVAQRVGGEPFLSRLQSDGVHFTVRRRVVYGDCTLSGTVYAPRLFNYAVEAVGEWYRETLGISWREQCIRLRGAPFREVWCERLAPLVPGQVITMTVGIPRLGKSSIGYEVVGYDDRGEPCFQVGMSACYISEETGSIKAIPFPDDMRSRILAYQVLCDQGVIPATAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U02</accession>
    <name>Q39U02_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2043</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2043"/>
    <dbReference type="EnsemblBacteria" id="ABB32272">
        <property type="protein sequence ID" value="ABB32272"/>
        <property type="gene ID" value="Gmet_2043"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2043"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227872_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033764">
        <property type="entry name" value="Sdr_B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17210">
        <property type="entry name" value="SdrD_B"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01451">
        <property type="entry name" value="B_ant_repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223266" evidence="3">
        <location>
            <begin position="25"/>
            <end position="2604"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="4">
        <location>
            <begin position="287"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="4">
        <location>
            <begin position="409"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="4">
        <location>
            <begin position="527"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="4">
        <location>
            <begin position="642"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="4">
        <location>
            <begin position="757"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="4">
        <location>
            <begin position="872"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="4">
        <location>
            <begin position="987"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="SdrD_B" evidence="4">
        <location>
            <begin position="1102"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1700"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1887"/>
            <end position="1926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2024"/>
            <end position="2051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2033"/>
            <end position="2051"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="2604" mass="279955" checksum="893DA2293248DDFD" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U08</accession>
    <name>Q39U08_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acylhomoserine lactone synthetase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512914.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2037"/>
    <dbReference type="EnsemblBacteria" id="ABB32266">
        <property type="protein sequence ID" value="ABB32266"/>
        <property type="gene ID" value="Gmet_2037"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2037"/>
    <dbReference type="eggNOG" id="COG3176">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072758_0_0_7"/>
    <dbReference type="OMA" id="WFCMVEP"/>
    <dbReference type="OrthoDB" id="1725271at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022484">
        <property type="entry name" value="PEP-CTERM/exosrtase_acylTfrase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03694">
        <property type="entry name" value="exosort_acyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="270" mass="31253" checksum="E6A7EDE8988BC52E" modified="2005-11-22" version="1">MTGRLSRLSPEPGLVDYFNLLYSVIPAETDELVKETFRLRYQVYCIENEFEPPSETSQQMETDEFDKNSVHSIIKYNKTGHSIGSVRMVLPNERDHTRSFPIQKICSHSIFTDRKLFSLYRPIEISRFCLSKELRTMAKPCKHMCVQLTSTRAPFSPSLLNQHGPILGLIRGLVQMSSENHVTHWFAIMEPSLIRLLAKLAIYFKPVGSLINYHGMRQPCYIELSELLRRVFSEQPLVWEVLTNKGQFDLNLTNYNESLSGSNLNKISRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U18</accession>
    <name>Q39U18_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2027"/>
    <dbReference type="EnsemblBacteria" id="ABB32256">
        <property type="protein sequence ID" value="ABB32256"/>
        <property type="gene ID" value="Gmet_2027"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2027"/>
    <dbReference type="eggNOG" id="ENOG5034AMF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_602379_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018759">
        <property type="entry name" value="BBP2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017467">
        <property type="entry name" value="CHP03016_PEP-CTERM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10082">
        <property type="entry name" value="BBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03016">
        <property type="entry name" value="pepcterm_hypo_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="468" mass="52707" checksum="73877E63668DFFD9" modified="2005-11-22" version="1">MSCCVAATAHAEFKLTPSLIIREEYNDNIDLTNENRRDDFITTIVPSLNALIDTNLLKLNLDYGLYFKLFAKHSEKDDTSLARTQRIRLDSTFNPIRDILFLKMSDVYARVPIDDRRQVGVGNDFVNTTDSNIFIANPYLVYPITSSISLTAGYTYKNTWYDDPQGQSAQDHTVTGRLTKSFGERLSIYGEYDFRTHLPKENINISITQFRTVTGAIRVGDTYIITSSIPSGESLQETGWNGYDTHTGTIGAMLQITPKLTLNGSVGKVYYRYKSGTLTGRTQYFIGATTVAEGPPVSQEYRLPDTDSLIWNAQANYLLSDRLSLEAHYSRDFTDSVNQGAYKRDTYGGSIKYNHTIETTLGGFHTKSSYETVNREDTSTGATMTARIPLGANLAANLLGNYTHYKFSPDNVTPITEKTNRYSAQAGLDYTFRIMTMGLGYTWNFNDSNVEAHDYFNNIVWLQAKLTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U27</accession>
    <name>Q39U27_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FemAB superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365904.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2018"/>
    <dbReference type="DNASU" id="3740675"/>
    <dbReference type="EnsemblBacteria" id="ABB32247">
        <property type="protein sequence ID" value="ABB32247"/>
        <property type="gene ID" value="Gmet_2018"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2018"/>
    <dbReference type="eggNOG" id="COG5653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046277_0_0_7"/>
    <dbReference type="OMA" id="NICEPSG"/>
    <dbReference type="OrthoDB" id="1856290at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="185"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="370" mass="42278" checksum="7B389358F1C03AAD" modified="2005-11-22" version="1">MNRGCFDIAVITDREAFQAILDEWNQLADINGYYTPWFCWEWFDLCLRHGETRALHILMVRSGGSLVAVAPFTVRSERYKGVVPARILSSIGGNRSPLKGIVFGDADENMQREVTTLVLEYLRTTFKNWDILELEPVAGSNDGNSIETLIERQGLSFRSYISCANRYCDVADASFDGFFERLPQSTRKDINYCRRRLEKNGSLVFQIITDAASLDQCLDVYDAVRAKSWKAAEKDREFNRELMHVAAGKGWLRLGILSYDGTPIAVQKWIVANGRAYIYDVLYDEEYKKHSPGKILTSMMFQHAIDNERVAYVDYLRGDEPYKEEWTPSLRNRIGIEAYNKSVLGCTASILMKKILPLVKKNTDSTNAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U37</accession>
    <name>Q39U37_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, CESA-like subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512942.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2008"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32237">
        <property type="protein sequence ID" value="ABB32237"/>
        <property type="gene ID" value="Gmet_2008"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2008"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046109_0_0_7"/>
    <dbReference type="OMA" id="RISAGNM"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="47"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="379" mass="43360" checksum="C6EEECC58B9F4330" modified="2005-11-22" version="1">MSEWIFWLLVVTIFYTYFGYALLIPLIGLFVKRPLDRRDITPRVTFLITAYNEEKNIRKKLTEVLALDYPWEQLEVMVASDGSTDRTDDIVREFRDQGVVLKRVEGRVGKTATQNEAVKAATGDVIIFSDATTVYEKDAIRKLVRNYNDPEVGAVSGRYEYVNPTGAPVGTGSILFWKYENFIKSMQTRIRTISGCCGCIYSVRKAAYVPLPGDIISDLVEPLMVIRGGYRVVFEQEAVAYEETTEKSHEEFRMRIRVITRAMRGILFARGLLNPFRFPFVAFQLFSHKVLRWLIPFFLIGLLVANAFLLDRQFYVITFVLQVAFYLLALFGLGADRVGKKFKPAAVPLYFCIVNTASLIAFFKTLAGQKMVTWETVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UA3</accession>
    <name>Q39UA3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small-conductance mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mscS-1</name>
        <name evidence="8" type="ordered locus">Gmet_1942</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511901.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1942"/>
    <dbReference type="EnsemblBacteria" id="ABB32171">
        <property type="protein sequence ID" value="ABB32171"/>
        <property type="gene ID" value="Gmet_1942"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1942"/>
    <dbReference type="eggNOG" id="COG3264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_0_1_7"/>
    <dbReference type="OMA" id="FPYRTIV"/>
    <dbReference type="OrthoDB" id="1597438at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="360" mass="40287" checksum="D0D0F7CE6FD010AC" modified="2005-11-22" version="1">MDNILNFLRLEESDHLLLFWLKEILVAVVIFTLFWGLSQVVRYILTSWVPRLTAFTRTGLDDRIIQRVTPPASLLVVFAGLYFAVRSLPLPEKAHVVLSGAVYILNIIVVTVIVERVIAELLEWYGAKLAERHGAGVDRQIIPPLEKIVTIFLVGIALMVTLRHFDYDIVSVLTALGVGSLAIGMAAKDTLANMISGFTLMVDRPFRIGDRIQLTSGQWGDVNDIGLRTTKIKTVDNTLLVIPNSELCNTTLINLAYPDTRAKGRINVGVGYESDVEKVKGIMIQTALDVPEVLPNPAPEAFFVSFGDSALGMSLFFWVEDYTRLFAVTDRINEQIINRFREHGITIPYPTRTVFLEKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UD9</accession>
    <name>Q39UD9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfate ABC transporter, periplasmic sulfate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysP</name>
        <name evidence="8" type="ordered locus">Gmet_1906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the prokaryotic sulfate-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511938.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1906"/>
    <dbReference type="EnsemblBacteria" id="ABB32135">
        <property type="protein sequence ID" value="ABB32135"/>
        <property type="gene ID" value="Gmet_1906"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1906"/>
    <dbReference type="eggNOG" id="COG1613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055615_0_1_7"/>
    <dbReference type="OMA" id="KDFGGWK"/>
    <dbReference type="OrthoDB" id="1111285at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901681">
        <property type="term" value="F:sulfur compound binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902358">
        <property type="term" value="P:sulfate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01005">
        <property type="entry name" value="PBP2_CysP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000957">
        <property type="entry name" value="Sulphate/thiosulphate-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034408">
        <property type="entry name" value="Sulphate/thiosulphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005669">
        <property type="entry name" value="Thiosulph/SO4-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30368">
        <property type="entry name" value="PTHR30368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00971">
        <property type="entry name" value="3a0106s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00401">
        <property type="entry name" value="PROK_SULFATE_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00757">
        <property type="entry name" value="PROK_SULFATE_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223306" evidence="7">
        <location>
            <begin position="26"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="337" mass="37225" checksum="EBFBC65B6C8B771B" modified="2005-11-22" version="1">MKPIRTIATLAAALLALAAPLAARAEVNLLNVSYDPTRELYQDYNAAFARYWKGKGGDTVTVKQSHGGSGKQARSVIDGLEADVVTLALAYDIDEIGERGKLIPANWQKRLPHNSSPYTSTIVFLVRKGNPKKIRDWNDLVRPDVKVITPNPKTSGGARWNYLAAWGYALKQKGGSEAKAKEFVTRLFRNVPVLDSGARGSTTTFVQRGQGDVLLAWENEAFLAVNELGRDKFQIVVPSVSILAEPPVTVVDKVVDRKGTRKVAEEYLKYLYTPAGQEIAARHYYRPIDKKVAARYAKVFPKVKLFTIDDTFGGWKAAQKKHFADGGVFDQIYGPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UF6</accession>
    <name>Q39UF6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydropteroate synthase</fullName>
            <shortName evidence="1">DHPS</shortName>
            <ecNumber evidence="1">2.5.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dihydropteroate pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">folP</name>
        <name evidence="3" type="ordered locus">Gmet_1889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DHPS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511955.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1889"/>
    <dbReference type="EnsemblBacteria" id="ABB32118">
        <property type="protein sequence ID" value="ABB32118"/>
        <property type="gene ID" value="Gmet_1889"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1889"/>
    <dbReference type="eggNOG" id="COG0294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008023_0_2_7"/>
    <dbReference type="OMA" id="FSIDTYH"/>
    <dbReference type="OrthoDB" id="1275854at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00156"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004156">
        <property type="term" value="F:dihydropteroate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00739">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045031">
        <property type="entry name" value="DHP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006390">
        <property type="entry name" value="DHP_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20941">
        <property type="entry name" value="PTHR20941"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01496">
        <property type="entry name" value="DHPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00792">
        <property type="entry name" value="DHPS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00793">
        <property type="entry name" value="DHPS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pterin-binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="290" mass="31462" checksum="8AB69D03FA4ADBC1" modified="2005-11-22" version="1">MGKSDEIVVPSFWRLAKRSLDLSRRPCIMGILNVTPDSFSDGSRYLDLDRAEERAHQMVEQGADIVDIGGESTRPNIAPVDADEELRRVIPLVERLAGRIPVPISVDTYKAVVAREALRVGAEIVNDISGLTFDPAMAATVAEADAGLVVMHTRGRPDTMQRDTAYGNLIAEVIDFLRQSVLIAEAAGVSKERIVVDPGIGFAKSVQGNLEILRQLRDVASLQLPILVGTSRKSFIGTILGRNVDERLFGTAATVALAVANGASIIRVHEVREMRDVADMAHAVLHPHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UI6</accession>
    <name>Q39UI6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Type II secretion system secretin lipoprotein PulQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">pulQ</name>
        <name evidence="11" type="ordered locus">Gmet_1859</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365881.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1859"/>
    <dbReference type="EnsemblBacteria" id="ABB32088">
        <property type="protein sequence ID" value="ABB32088"/>
        <property type="gene ID" value="Gmet_1859"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1859"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017432_1_0_7"/>
    <dbReference type="OMA" id="FWSGRED"/>
    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223521" evidence="9">
        <location>
            <begin position="22"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="71"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="120"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="10">
        <location>
            <begin position="206"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="624"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="648"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="146"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="660"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="861" mass="92618" checksum="27DE1F218085E79A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UI7</accession>
    <name>Q39UI7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system pseudopilin PulG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pulG</name>
        <name evidence="3" type="ordered locus">Gmet_1858</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1858"/>
    <dbReference type="EnsemblBacteria" id="ABB32087">
        <property type="protein sequence ID" value="ABB32087"/>
        <property type="gene ID" value="Gmet_1858"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1858"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_7_2_7"/>
    <dbReference type="OMA" id="IDHYKDA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="161" mass="18545" checksum="6EAF3046AEC2A113" modified="2005-11-22" version="1">MRYIRNRKGLSFIELIMTVTILGILATVIVPFTQMTVKRNKELELRRSLREIRTAIDEYKKAYDDAHKGKQILNETGYPETLEVLVTGTDFGGEAKSTKKKFLRRIPVDPFNRPASGEKPEWGLRSYKDEPDSTTWDNSDVYDVYSLSEGTAIDGTKYKDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UX7</accession>
    <name>Q39UX7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514138.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1716"/>
    <dbReference type="EnsemblBacteria" id="ABB31947">
        <property type="protein sequence ID" value="ABB31947"/>
        <property type="gene ID" value="Gmet_1716"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1716"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_7"/>
    <dbReference type="OMA" id="WERFEND"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="27493" checksum="728C7BDAFF656187" modified="2005-11-22" version="1">MEFKNLLIETADGVATLTVNRPQALNALNSEVLTELASAFYQLEYDPAVRVVVLTGAGEKAFVAGADIKEMAAMSSFEGHQFALKGQHCMMAMEKMKTPVIAAVNGFALGGGLELALGCDFIYASEKAKLGFPEVTLGIIPGFGGTQNLARLIGKNRANELIFTGRMIAADKAQAWGIVNEVFAPEELLVKAKETAAAIAGVGPLGVTYAKNAIANGLNMGKEDGFRYEASLFGVLFGTADQKEGMGAFVEKRKAVFTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UY3</accession>
    <name>Q39UY3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Short-chain acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514144.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1710"/>
    <dbReference type="EnsemblBacteria" id="ABB31941">
        <property type="protein sequence ID" value="ABB31941"/>
        <property type="gene ID" value="Gmet_1710"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1710"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_1_7"/>
    <dbReference type="OMA" id="NMATWML"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="124"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="232"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="386" mass="41395" checksum="3401C1F863F2B81F" modified="2005-11-22" version="1">MYLELTEEQKLIQDTARDFAKAELEPVAAQLDQGSDRGPLLANLKKLAELGFMGLNVREEYGGAEAGAISFSVAMTEIARACASTAVTVSVNNMAAEVIQVVGSEEQKRAYIPKICSGEYSAASFALTETCAGSDPAGMVTQAVDDGDSWVLNGSKIFITSASYAGVFVVWAVTDKAAPKGKGISCFLVEAGTPGLIIGKEEHKMGQHASATNEVIFTDCRIPKSAMMGKLNDGFRIAVAELAGGRIGIGSLGLGVGLAAMDHATRYASERTQFGQKISNFQAIQWMVADAYTELEAARLLLMNAAFRKDQGKSFAKEASMAKLYATEAANRACYAAIQMLGGYGYTQDFPVERYARDARITSIYEGTSEIQRVVISREILKNFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V37</accession>
    <name>Q39V37_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511407.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1656"/>
    <dbReference type="EnsemblBacteria" id="ABB31887">
        <property type="protein sequence ID" value="ABB31887"/>
        <property type="gene ID" value="Gmet_1656"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1656"/>
    <dbReference type="HOGENOM" id="CLU_2093333_0_0_7"/>
    <dbReference type="OMA" id="HRRTTIG"/>
    <dbReference type="OrthoDB" id="2069119at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="121" mass="13242" checksum="746B2E95C7CFD87B" modified="2005-11-22" version="1">MNSEPLEGQMALFETPAEPEKKKPAPKKAARGKDSETPKKKEVKKVVAREQAATRKPSQKARGKSKGTAKARSTSGLVPEGDVRLTANIREDLHLKLKIAAAHKRTTIGELIEMLVAKHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V54</accession>
    <name>Q39V54_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ROK domain transcriptional regulator/sugar kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1639</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511425.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1639"/>
    <dbReference type="EnsemblBacteria" id="ABB31870">
        <property type="protein sequence ID" value="ABB31870"/>
        <property type="gene ID" value="Gmet_1639"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1639"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_4_7"/>
    <dbReference type="OMA" id="FEPEVIC"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="324" mass="33670" checksum="0F41171371F5E42F" modified="2005-11-22" version="1">MNGNKRAYIGIDIGGTNLRMALIDERGAIIHKTKSRTDIHHGRSSFLSRLGKGIESLLLAARDNNIEPAGLGAGVPGLIANDGHVYVSVNLRPLDGVNLRDELQAMSGLPAVVANDVNAFAFGESVYGAGRDYRSFLMVTLGTGVGGGLILDGKVWSGIDGVAGEFGHMTVESEGRPCPCGNRGCLEQYASASALVSAAREMICQQKDVFGAQCDMDAISTKILAAAALDGNQAALGLFADAGRYLGIAAASVANLLNLEAIILGGGVSSSFNLLCESMRREVLARAFPIPGKRLVIRQASLGDDGGILGSAALARSFLQEGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V75</accession>
    <name>Q39V75_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511446.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1618"/>
    <dbReference type="EnsemblBacteria" id="ABB31849">
        <property type="protein sequence ID" value="ABB31849"/>
        <property type="gene ID" value="Gmet_1618"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1618"/>
    <dbReference type="eggNOG" id="COG1728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147211_0_0_7"/>
    <dbReference type="OMA" id="KDHIRIV"/>
    <dbReference type="OrthoDB" id="1717041at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005585">
        <property type="entry name" value="DUF327"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024042">
        <property type="entry name" value="TM1646-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03885">
        <property type="entry name" value="DUF327"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158397">
        <property type="entry name" value="SSF158397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="151" mass="17008" checksum="8A552F9776747ACC" modified="2005-11-22" version="1">MRINDKISSRDVGKKAGKGALVRTGGGEANSPFVRALTLHRTELDTYEQQLQDLKEEIDRAGTDLEREPTVANFRTFRDLIATLAKTVTSNAYRLERVGGTSLNPRCFEIITVIDREADNLLNLIMTENKDRLKITNKIMELKGLIVDFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V92</accession>
    <name>Q39V92_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Malonyl CoA-acyl carrier protein transacylase</fullName>
            <ecNumber evidence="2 5">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabD-2</name>
        <name evidence="8" type="ordered locus">Gmet_1600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the fabD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="2 5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511465.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1600"/>
    <dbReference type="EnsemblBacteria" id="ABB31832">
        <property type="protein sequence ID" value="ABB31832"/>
        <property type="gene ID" value="Gmet_1600"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1600"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_0_1_7"/>
    <dbReference type="OMA" id="AANYNCP"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024925">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004410">
        <property type="entry name" value="Malonyl_CoA-ACP_transAc_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000446">
        <property type="entry name" value="Mct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00128">
        <property type="entry name" value="fabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="7">
        <location>
            <begin position="7"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000446-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="308" mass="32185" checksum="4DD78448AEE8B084" modified="2005-11-22" version="1">MSRRAFIFPGQGSQYPGMGKDLADNFALARKTFEEADDALGDNLSRLCFDGPEDQLKLTANTQPSILTVSVAALRVLQEETGLSAQYFAGHSLGEYSALVAAGVIQFADAVRTVRARGTFMQEAVPVGVGAMAAMLSIEPDVLAAICAEAAQGEEVSPANFNSPGQIVIAGHTGAVNRAIEIAKAKGFRKAMLLPVSAPFHSSLMVPAGERLAGVLAPITVGAFSAPVVTNVEAKPNDDKARVKELLVRQVSAPVLWDASVREMVALGVTEFVEVGPGKVLSGLVKRIDKGVSTKNVEDAAGIKAIGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VC1</accession>
    <name>Q39VC1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA (5-carboxymethylaminomethyl-2-thio-U34) synthesis sulfur carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tusA-1</name>
        <name evidence="3" type="ordered locus">Gmet_1571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511494.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1571"/>
    <dbReference type="EnsemblBacteria" id="ABB31803">
        <property type="protein sequence ID" value="ABB31803"/>
        <property type="gene ID" value="Gmet_1571"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1571"/>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_165255_2_1_7"/>
    <dbReference type="OMA" id="RMNEGEP"/>
    <dbReference type="OrthoDB" id="2042068at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="74" mass="8121" checksum="84780B415E8A59B8" modified="2005-11-22" version="1">MTTIDLRGVTCPTNFVKAKLALEMVDTGEVVEFLLDDGEPVKNVPRSLKGEGHKLVGLKEVNGYYILTLEKGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VG6</accession>
    <name>Q39VG6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">(E)-2-benzylidenesuccinyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bbsH</name>
        <name evidence="3" type="ordered locus">Gmet_1524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511543.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1524"/>
    <dbReference type="EnsemblBacteria" id="ABB31758">
        <property type="protein sequence ID" value="ABB31758"/>
        <property type="gene ID" value="Gmet_1524"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1524"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_7"/>
    <dbReference type="OMA" id="HRWGFVN"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="256" mass="27723" checksum="962BF1D674B09EA4" modified="2005-11-22" version="1">MGVDFVTEGNVAYITLNRPDAMNALDPEGLVRLAEIWGEVKNNPEIRIAVLTGAGEKAFCTGTDMKKAKVPDECMAALYYKEGQPIIPHMKMWKPIIACINGYAVGGGLEMALACDLRICSTTAKFALTETKVASLAGLNGTQCLPRAIPQAVAMKMLLTGEMIDAAEAHRVGLVSDVAEPDQLMALARKYAEKIASNAPLSVMAAKQAAVMGMDMPLPHAIDFSYLLWGILRDTEDRKEGFTAFAEKRAPQYRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VM6</accession>
    <name>Q39VM6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511606.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1464"/>
    <dbReference type="EnsemblBacteria" id="ABB31698">
        <property type="protein sequence ID" value="ABB31698"/>
        <property type="gene ID" value="Gmet_1464"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1464"/>
    <dbReference type="HOGENOM" id="CLU_965628_0_0_7"/>
    <dbReference type="OMA" id="ESAMFAH"/>
    <dbReference type="OrthoDB" id="1718327at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="317" mass="35841" checksum="AAA558977DFF1512" modified="2005-11-22" version="1">MSEGCGIALTMLIIDDDERYVDALFRDARRAGIRLLHAGSLEEGKLVVEGVDGAGICGVILDVECYKRRDDATPDSSFIIAATKYFTEKAPHLPVVALTGVQALFDRYVKDFAGIWQVYKKGRDESAMFAHLRQRALELEWVKVAGRYPDVFRVVDTYLGADTRQALMDCLLTMDDGTPARIRGNLANLRSIQEKLYIVLHRHRPDMVPRRFIYYEHGDQPLKSVNVAAILEHLKGNFDMRRQQIQGEVFLHYRSPLYRFSELVYRVSSDGIHAIDEDSADKPTRYTVQAVANALLELVLWFGRVAGEGSIECTGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VR1</accession>
    <name>Q39VR1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer membrane lipoprotein, Slp family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1429</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511639.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1429"/>
    <dbReference type="EnsemblBacteria" id="ABB31663">
        <property type="protein sequence ID" value="ABB31663"/>
        <property type="gene ID" value="Gmet_1429"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1429"/>
    <dbReference type="eggNOG" id="COG3065">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100924_2_1_7"/>
    <dbReference type="OMA" id="MNATGYK"/>
    <dbReference type="OrthoDB" id="1751057at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004658">
        <property type="entry name" value="OMP_Slp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37530">
        <property type="entry name" value="PTHR37530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03843">
        <property type="entry name" value="Slp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004982">
        <property type="entry name" value="SlP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="190" mass="21879" checksum="C54A4D2C85819850" modified="2005-11-22" version="1">MYLQRISILIILLTTLSLSGCAHVISEQSRSLVDPTITYAMLKEKPDAFVGKYVQLGGVIVGVKNTTTGSQLEIMQVALDKTGMPEDTFRSEGRFLAISESFLDSMIYKPDRLVTLVGEVKGKKVMPVDEVEYTYPVLAIKEIYVWKSYDYEKGYPYPTPPPYSFYDPYYYGYWPGPYWYRPLGPVYRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VS3</accession>
    <name>Q39VS3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integration host factor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ihfA-1</name>
        <name evidence="9" type="ordered locus">Gmet_1417</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511650.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1417"/>
    <dbReference type="EnsemblBacteria" id="ABB31651">
        <property type="protein sequence ID" value="ABB31651"/>
        <property type="gene ID" value="Gmet_1417"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1417"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_1_3_7"/>
    <dbReference type="OMA" id="ANHLWEV"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13835">
        <property type="entry name" value="IHF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005684">
        <property type="entry name" value="IHF_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="91" mass="10227" checksum="A098AFE1770B7C84" modified="2005-11-22" version="1">MTKADIVEQIYEKVGFSKKESAELVERVFGLIKETLENGEKIKIAGFGNFVVKEKADRRGRNPQTGDEIIISARRILTFKPSQVLKSSINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VY1</accession>
    <name>Q39VY1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="1">1.1.1.42</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Oxalosuccinate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">icd</name>
        <name evidence="6" type="ordered locus">Gmet_1359</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="4">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="4">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the monomeric-type IDH family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513149.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1359"/>
    <dbReference type="EnsemblBacteria" id="ABB31593">
        <property type="protein sequence ID" value="ABB31593"/>
        <property type="gene ID" value="Gmet_1359"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1359"/>
    <dbReference type="eggNOG" id="COG2838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025308_1_0_7"/>
    <dbReference type="OMA" id="FRMCQTK"/>
    <dbReference type="OrthoDB" id="222705at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004436">
        <property type="entry name" value="Isocitrate_DH_NADP_mono"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36999">
        <property type="entry name" value="PTHR36999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03971">
        <property type="entry name" value="IDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009407">
        <property type="entry name" value="IDH_monmr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00178">
        <property type="entry name" value="monomer_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 5" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="132"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="82"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="547"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="584"/>
            <end position="585"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="589"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="600"/>
            <end position="602"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="649"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="2">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR009407-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="740" mass="81190" checksum="9D6676477BA48144" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W36</accession>
    <name>Q39W36_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PhoH-related ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1302</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PhoH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512064.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1302"/>
    <dbReference type="DNASU" id="3739471"/>
    <dbReference type="EnsemblBacteria" id="ABB31538">
        <property type="protein sequence ID" value="ABB31538"/>
        <property type="gene ID" value="Gmet_1302"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1302"/>
    <dbReference type="eggNOG" id="COG1875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022283_2_1_7"/>
    <dbReference type="OMA" id="KMSPWAQ"/>
    <dbReference type="OrthoDB" id="445854at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003714">
        <property type="entry name" value="PhoH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02562">
        <property type="entry name" value="PhoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13638">
        <property type="entry name" value="PIN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PINc" evidence="4">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="439" mass="49140" checksum="A5350BE3DBFFB5F2" modified="2005-11-22" version="1">MKNFVLDTNVLLYDPQAIFKFEENNIIIPITVIEEVDRFKKDMNETGRNARQVSRYLDDMRKIGSLSSGITLETGGMLRVEMYEEKIMKRLPPELREERGDNRILAVAVKILEENGGAPVVFVTKDTNLRIKADAIGLKAEDYESDKVDIEELYPGFTEIDVAADTVDRFHGQGWVELPGQTFFPNQCVTLRDEANPSHTALGKYRVGDGKITPLIKTGKEGVWSIFPRNREQAFAFDLLLDDSIKLVTLVGKAGTGKTLLAIAAGLHKTAEENVFNRLLVSRPVFPMGRDLGFLPGDIEEKLAPWMQPIFDNVELLLSGHEAEKRHSKGYKELMAMGIMEIEPLTYIRGRSIPNQFMIVDEAQNLTPHEIKTIITRAGEGTKIVLTGDPYQIDNPYVDASSNGLTYVVERFKEQAIAGHVTMTKGERSDLAELAANLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W50</accession>
    <name>Q39W50_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphocarrier protein HPr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ptsH</name>
        <name evidence="5" type="ordered locus">Gmet_1288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512078.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1288"/>
    <dbReference type="EnsemblBacteria" id="ABB31524">
        <property type="protein sequence ID" value="ABB31524"/>
        <property type="gene ID" value="Gmet_1288"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1288"/>
    <dbReference type="eggNOG" id="COG1925">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136230_1_1_7"/>
    <dbReference type="OMA" id="SIMAMMM"/>
    <dbReference type="OrthoDB" id="404807at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00367">
        <property type="entry name" value="PTS-HPr_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000032">
        <property type="entry name" value="HPr-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035895">
        <property type="entry name" value="HPr-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001020">
        <property type="entry name" value="PTS_HPr_His_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002114">
        <property type="entry name" value="PTS_HPr_Ser_P_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00381">
        <property type="entry name" value="PTS-HPr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00107">
        <property type="entry name" value="PHOSPHOCPHPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55594">
        <property type="entry name" value="SSF55594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01003">
        <property type="entry name" value="PTS_HPr_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51350">
        <property type="entry name" value="PTS_HPR_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00369">
        <property type="entry name" value="PTS_HPR_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00589">
        <property type="entry name" value="PTS_HPR_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPr" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="88" mass="9538" checksum="8B608B268D2668C7" modified="2005-11-22" version="1">MLDQEFTIINKLGLHARASALFVKTASRFRSDIKIVREGIEVNGKSIMGIMMLAAAKGTLIRVKIEGEDEAEAMAALGELITNGFGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W98</accession>
    <name>Q39W98_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CdhD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512129.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1240"/>
    <dbReference type="EnsemblBacteria" id="ABB31476">
        <property type="protein sequence ID" value="ABB31476"/>
        <property type="gene ID" value="Gmet_1240"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1240"/>
    <dbReference type="eggNOG" id="COG1456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_830865_0_0_7"/>
    <dbReference type="OMA" id="WKARWGI"/>
    <dbReference type="OrthoDB" id="1424368at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016041">
        <property type="entry name" value="Ac-CoA_synth_d_su_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03599">
        <property type="entry name" value="CdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="CdhD" evidence="2">
        <location>
            <begin position="30"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="323" mass="34719" checksum="1049D4C563ACB27C" modified="2005-11-22" version="1">MPIVSTEFRFADRLGAWKARWGIGRMSYLVPPGLYAIGSPGPEDPVVVTANYKMSYDLVRRELSGRNVWFLVLETFGINVWCAAGKGTFGTDELVRRVGMVKLATVVKHRALILPILGAPGVAAHQVARRSGFRVHYATIRAADLPEYLDNGMVTTPEMRQLTFTTRERLALTPIELVTTGKWVVPFVALLVVLSIVPGGLLSSPTLVSSLVLFVGTVLAGAVAAPVLLPWLPGKSFAVKGAVAGCCWAVLFIGVGRGATGWLDAMALFLTVPAVTAFLTLNFTGSTPFTSRSGVKKEMRLGLPMMAVSLLAGISLWIAARFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WE7</accession>
    <name>Q39WE7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux pump, RND family, outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512180.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1190"/>
    <dbReference type="EnsemblBacteria" id="ABB31427">
        <property type="protein sequence ID" value="ABB31427"/>
        <property type="gene ID" value="Gmet_1190"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1190"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022604_2_0_7"/>
    <dbReference type="OMA" id="MNINPAY"/>
    <dbReference type="OrthoDB" id="877398at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="510" mass="56678" checksum="C697AEE243A67A37" modified="2005-11-22" version="1">MDFTYPPTCSKQFRGILKVSVRYALPLAMALSASTGHCDTLPDTLSLSRGMAIEMAIRKNIDLRVESLNYSMAETDVDRSWGIYNPILVVSGTGGVTSVPGDPFFSSRYSTGSIGLTQYLPTGGYFSASTQSGYTNAEVSNPDSSTSTWQSTAGLALSQPLLKNAGKQTMELSITLAANALEDSRERYRFTTTDTVLAVITAYNHLYTLRQTLETKRGALKSAQDFLEELRKRPKPTALQKIELANTEYTIAQRLKDLVEAERSVSDQEANLRYLIGMEQKTRIIPVDPPPREEPQTTEDQAVKSALEYRSDLKQLRITLKSSQLQERVADHQTLPELTVSGSGGLTGTGTNFAESYRKVAQKPGTYWSAGMQLNVPLGNTAAYNDYLKNKIRTEQVQNQIDALVWKIRNDVEADMRALISARLQIQTTEKALQYAEQRHDEYRNQTRAGATTVQDFINAENDLIAARNAHQDSTEAFAYAVSKLWRDTGELLDHQGVRITSPDQLKSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WE9</accession>
    <name>Q39WE9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidoglycan-binding domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512182.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1188"/>
    <dbReference type="EnsemblBacteria" id="ABB31425">
        <property type="protein sequence ID" value="ABB31425"/>
        <property type="gene ID" value="Gmet_1188"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1188"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_887754_0_0_7"/>
    <dbReference type="OMA" id="FGALQWN"/>
    <dbReference type="OrthoDB" id="1438364at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="321" mass="35441" checksum="F903A283A289A9B1" modified="2005-11-22" version="1">MTNAYRRGSTGAEVKTIQTRLAGLGLYSGDTDGIFGGGTESAVKNFQRKNGLDVDGIVGEDTWKKLFHGEKLLEPEIGKQTLAYRCLALTGTIETGKPIPHCFAVVSGDFDGQGLSFGALQWNLGQGSLQPLFQEMAEKYPSQLESICHDYFPELKAIFTSDKDDQLAWVRSVQDQQRFSLFEPWKGLLTTLGRTAEFQNIQIGAAGMLFSDAKDLCAEYGLWSERGVALMFDIKTQNGSISPLVKSQIMADFSRLGGDLSKDETEEARLIIVANRRAEASNPRWIEDVRKRKVAIACGEGMVHGNYLHLEDQFGIGLKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WG6</accession>
    <name>Q39WG6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase, MutT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513436.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1170"/>
    <dbReference type="EnsemblBacteria" id="ABB31408">
        <property type="protein sequence ID" value="ABB31408"/>
        <property type="gene ID" value="Gmet_1170"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1170"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_19_3_7"/>
    <dbReference type="OMA" id="ELAFYAG"/>
    <dbReference type="OrthoDB" id="1538300at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="137" mass="15723" checksum="B5A68546CD920C2B" modified="2005-11-22" version="1">MLPLIVTAAVIEHEGKILLTRRKPDAPYPLLWEFPGGKLEPEEHPEACIVREVREELAMDVSVHGIYDVVYYRYPERPVLVLAYRCAWTGGELRELDVADHSWVDPADILRFDLLPADYPLAKKIVHEFSDADTTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WH7</accession>
    <name>Q39WH7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 5">2.7.7.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">UDP-glucose pyrophosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">galU</name>
        <name evidence="7" type="ordered locus">Gmet_1159</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UDPGP type 2 family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513424.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1159"/>
    <dbReference type="EnsemblBacteria" id="ABB31397">
        <property type="protein sequence ID" value="ABB31397"/>
        <property type="gene ID" value="Gmet_1159"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1159"/>
    <dbReference type="eggNOG" id="COG1210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_1_2_7"/>
    <dbReference type="OMA" id="MHYVRQG"/>
    <dbReference type="OrthoDB" id="1402673at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02541">
        <property type="entry name" value="UGPase_prokaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005771">
        <property type="entry name" value="GalU_uridylyltTrfase_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43197">
        <property type="entry name" value="PTHR43197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01099">
        <property type="entry name" value="galU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="291" mass="32809" checksum="4BDEA52EF147B2DF" modified="2005-11-22" version="1">MQVKKAVFPVAGLGTRFLPATKASPKEMLPLIDKPLVQYVVEEAVAAGIEQILFVTGRGKRAIEDHFDISFELEALLQEKGKNDTLREVRDIAEMVNIFYVRQKQAMGLGHAILCAREFVGNEPFAVLLGDDIIDAEKPCLGQLLDVYRKYRGPVLALEKVPMENISSYGCVRANGITDRIFEVTDLVEKPKREEAPSDMAIIGRYVLTPEIFPILERQEPGKGGEIQLTDALLKLSKDEAIYGCLFEGIRHDCGDKLGFLKATVDMALKREEFNTEFEEYLRERLCRRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WN0</accession>
    <name>Q39WN0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mannose-1-phosphate guanylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513760.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1104"/>
    <dbReference type="EnsemblBacteria" id="ABB31344">
        <property type="protein sequence ID" value="ABB31344"/>
        <property type="gene ID" value="Gmet_1104"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1104"/>
    <dbReference type="eggNOG" id="COG0836">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035527_0_1_7"/>
    <dbReference type="OMA" id="QRPMYEE"/>
    <dbReference type="OrthoDB" id="224217at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005976">
        <property type="term" value="P:polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001538">
        <property type="entry name" value="Man6P_isomerase-2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01050">
        <property type="entry name" value="MannoseP_isomer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="MannoseP_isomer" evidence="2">
        <location>
            <begin position="316"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="357" mass="39200" checksum="98EA2E828E26CF4C" modified="2005-11-22" version="1">MYVVILAGGSGTRFWPLSRKLHPKQLMSVFGGKSMLQRTAERVLPLNPKRILVITNHLQAEETRRQLEYLRGVRIEVIEEPLGRNTAPAICLAATLIARHDPEAVMAVLPADHFIRDEDAFCATIQKGREAALNGYLVTLGITPDRPETGYGYIEAETSLRGDGPYPVKRFVEKPDRERALEFLAAGTFFWNSGMFLWRADVILGQMAAHMPELAQAFAGITFSPDIWEPADLAPQIEAVYAMVKGESIDYGVMEKADSVAMIPASFGWSDVGSWSALPEVMEPDAAGNVVIGAPETVIADAAGCILRGEKLMALVGVRDLVVVDTPDALLVCAKDRAQDVKKVVEELERRGLRRCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WT2</accession>
    <name>Q39WT2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1052"/>
    <dbReference type="EnsemblBacteria" id="ABB31292">
        <property type="protein sequence ID" value="ABB31292"/>
        <property type="gene ID" value="Gmet_1052"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1052"/>
    <dbReference type="HOGENOM" id="CLU_166635_0_0_7"/>
    <dbReference type="OMA" id="QGDHRHY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045397">
        <property type="entry name" value="DUF6516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20126">
        <property type="entry name" value="DUF6516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="101" mass="11801" checksum="2502DE019E96742E" modified="2005-11-22" version="1">MVYKTNMKARLIRHTKVTDELGNTLEMKLWQVAPASDKPHGFRYSLVYIVNGERAIGYDNGERQGDHRHYGDFQESYAFTSLQKLADDFLADIERFKEQTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X05</accession>
    <name>AROK_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shikimate kinase</fullName>
            <shortName evidence="1">SK</shortName>
            <ecNumber evidence="1">2.7.1.71</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroK</name>
        <name type="ordered locus">Gmet_0977</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + shikimate = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the shikimate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.71" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31219.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514372.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X05"/>
    <dbReference type="SMR" id="Q39X05"/>
    <dbReference type="STRING" id="269799.Gmet_0977"/>
    <dbReference type="EnsemblBacteria" id="ABB31219">
        <property type="protein sequence ID" value="ABB31219"/>
        <property type="gene ID" value="Gmet_0977"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0977"/>
    <dbReference type="eggNOG" id="COG0703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057607_4_0_7"/>
    <dbReference type="OMA" id="IGKHLFE"/>
    <dbReference type="OrthoDB" id="1392851at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00088"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000237883" description="Shikimate kinase">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00109"/>
        </source>
    </evidence>
    <sequence length="179" mass="19600" checksum="4BE00E0F0BD9A264" modified="2013-07-24" version="2">MATSTISAPSSVRNVILTGFMGTGKSSVGRLLAHRLGFRYCDLDALIVEGEGVSINEIFARHGEPHFRALETEAVRSVSREERCVVSTGGGAVISPENRCLLRKAGVVVNLTATVEEVCRRLREETDRPLLKDDRSGERIAAMMAEREQFYADAELRIDTTGKSVEDVVAEITGYLEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X33</accession>
    <name>Q39X33_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Indolepyruvate:ferredoxin oxidoreductase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iorB-2</name>
        <name evidence="3" type="ordered locus">Gmet_0949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514432.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0949"/>
    <dbReference type="EnsemblBacteria" id="ABB31191">
        <property type="protein sequence ID" value="ABB31191"/>
        <property type="gene ID" value="Gmet_0949"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0949"/>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_1_1_7"/>
    <dbReference type="OMA" id="ALRAYKY"/>
    <dbReference type="OrthoDB" id="1603697at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="12"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="181" mass="18935" checksum="5DB0BD2CC29D1E78" modified="2005-11-22" version="1">MTGQQLIISGVGGQGILFLTRILAETAISLGMPVMTSETHGMAQRGGVVISHLKAGEFSSPLVRPGRADGLIAMKAENVAIHRHFLRPGGWVVVNAKAAPAGLDGHPVHVIDADTLALELGNPQSLNLILIGYAVARFAASGDFFSPDQVIGTIERRLVEKGKLRDASLAALRLGMENAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X34</accession>
    <name>Q39X34_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Indolepyruvate oxidoreductase subunit IorA</fullName>
            <shortName evidence="4">IOR</shortName>
            <ecNumber evidence="4">1.2.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Indolepyruvate ferredoxin oxidoreductase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">iorA-2</name>
        <name evidence="7" type="ordered locus">Gmet_0948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>CoA + indole-3-pyruvate + 2 oxidized [2Fe-2S]-[ferredoxin] = (indol-3-yl)acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:12645"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17640"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57271"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="EC" id="1.2.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4 5">Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.</text>
    </comment>
    <dbReference type="EC" id="1.2.7.8" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0948"/>
    <dbReference type="EnsemblBacteria" id="ABB31190">
        <property type="protein sequence ID" value="ABB31190"/>
        <property type="gene ID" value="Gmet_0948"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0948"/>
    <dbReference type="eggNOG" id="COG4231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017727_0_0_7"/>
    <dbReference type="OMA" id="HVGVNIA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043805">
        <property type="term" value="F:indolepyruvate ferredoxin oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045025">
        <property type="entry name" value="HACL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017721">
        <property type="entry name" value="IorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43710">
        <property type="entry name" value="PTHR43710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006439">
        <property type="entry name" value="Indolepyruvate_ferr_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="572"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR006439-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="601" mass="64258" checksum="E8B42A45AA0EA612" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XA7</accession>
    <name>Q39XA7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0875</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513021.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0875"/>
    <dbReference type="EnsemblBacteria" id="ABB31117">
        <property type="protein sequence ID" value="ABB31117"/>
        <property type="gene ID" value="Gmet_0875"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0875"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="KYTARRE"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="156"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="111"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="368" mass="41172" checksum="01246165C444CE7F" modified="2005-11-22" version="1">MDAELVRAKLASEEISCTITVAPDGKQFARVLEESADCFDLILADMSIPGYDGVAALKLALEQCPDTPFIVISGTVGEERAVETLRKGATDFILKGNMGRLGSAIRRALKEAEEHCNRQRAEESLRRLNAELEQRVQERTAQLEATNQELQAFNFSVSHDLRAPLTIIDGFSKAILEDFGTDLPSEALDYLQRIQKAGQRMTRLIDALLNLSRLGREPITPEQTDLSAIAGTIEQELRYIHPDRTGVTIRITDGITVRGDRRLLRSVVENLLSNAWKYTARREQAEIEFGVMKQGEKPVYFVRDNGAGFDMRYAGQLFTPFQRMHRSEEFEGNGIGLATVQRIVHRHGGRIWAEAEEGKGATFFFTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XD3</accession>
    <name>Q39XD3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sensor cyclic diguanylate phosphodiesterase, HAMP and GAF domain-containing, putative heme-binding site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0849</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365732.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0849"/>
    <dbReference type="EnsemblBacteria" id="ABB31091">
        <property type="protein sequence ID" value="ABB31091"/>
        <property type="gene ID" value="Gmet_0849"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0849"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023732_0_0_7"/>
    <dbReference type="OMA" id="RLCIGQH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="199"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="4">
        <location>
            <begin position="491"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="270"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="710" mass="79941" checksum="542B8D95E065CCA7" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XE4</accession>
    <name>Q39XE4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aerobic-type carbon monoxide dehydrogenase, small subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512982.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0838"/>
    <dbReference type="EnsemblBacteria" id="ABB31080">
        <property type="protein sequence ID" value="ABB31080"/>
        <property type="gene ID" value="Gmet_0838"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0838"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_0_7"/>
    <dbReference type="OMA" id="IIHYLTG"/>
    <dbReference type="OrthoDB" id="1819473at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="154" mass="16172" checksum="72BD0FCE66ACCB0A" modified="2005-11-22" version="1">MIALTVNGTRHQVDVPPDTPLLWVIREVIGLTGTKFGCGMSLCGACTVHVEGRAIRSCVTPVSAVAGKEVTTIEGIPESHPVKQAWIADDVPQCGWCQPGQIMAATALLATNPKPDDAAIDEAMEGILCRCGTYQRIRRAIHRAAGTPAKGGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XP3</accession>
    <name>Q39XP3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/solute symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">aplA</name>
        <name evidence="11" type="ordered locus">Gmet_0739</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30981.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514456.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0739"/>
    <dbReference type="EnsemblBacteria" id="ABB30981">
        <property type="protein sequence ID" value="ABB30981"/>
        <property type="gene ID" value="Gmet_0739"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0739"/>
    <dbReference type="eggNOG" id="COG4147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_8_3_7"/>
    <dbReference type="OMA" id="LEYWMAV"/>
    <dbReference type="OrthoDB" id="278483at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00456">
        <property type="entry name" value="NA_SOLUT_SYMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223438" evidence="10">
        <location>
            <begin position="22"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="614"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30981.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="660" mass="69039" checksum="1B020DEE49BDDCF9" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XY6</accession>
    <name>Q39XY6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Protein translocase subunit SecY</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">secY</name>
        <name evidence="13" type="ordered locus">Gmet_0646</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 12">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514256.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0646"/>
    <dbReference type="EnsemblBacteria" id="ABB30888">
        <property type="protein sequence ID" value="ABB30888"/>
        <property type="gene ID" value="Gmet_0646"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0646"/>
    <dbReference type="eggNOG" id="COG0201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030313_0_2_7"/>
    <dbReference type="OMA" id="FAMWLGE"/>
    <dbReference type="OrthoDB" id="1567535at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01465">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026593">
        <property type="entry name" value="SecY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="PTHR10906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="SSF103491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="70"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB30888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="435" mass="47440" checksum="A2CC2E9D4C79F8F5" modified="2005-11-22" version="1">MIEAFQNIFRIPELKKRVLFSLGMLAVYRVGCHIPTPGIDSTALAHFFAQARGTLLGLFDMFSGGALEKLTVFALGIMPYISSSIIFQLLTVVVPAIEKLSKEGESGRKKIIQYTRYGTIVLSVVQALGISIGLESMRGPAGELVVPSPGWGFRFMTVITLTAGTAFIMWLGEQMSEKGIGNGISLIIFAGIVARIPVALGNSVRLLKTGQISLFVILFILVLMFLVIAAIVFVERGQRRLPIHYAKRVVGLKTYGGQTSHLPLKVNMAGVIPPIFASSIIMFPATVANFINIPWVQSAAKSLTPGNWVYDIFYVAFIVFFCYFYTAVSFNPVDVADNVKKHGGYIPGIRPGKETSEYLDRVLTKLTFAGAIYISAVCVLPSILIGKFNLPFYFGGTALLIAVGVGMDTAAQIESHLITRSYEGFMKGVRVRGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y24</accession>
    <name>Q39Y24_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 7">30S ribosomal protein S9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">rpsI</name>
        <name evidence="8" type="ordered locus">Gmet_0607</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514737.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0607"/>
    <dbReference type="EnsemblBacteria" id="ABB30850">
        <property type="protein sequence ID" value="ABB30850"/>
        <property type="gene ID" value="Gmet_0607"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0607"/>
    <dbReference type="eggNOG" id="COG0103">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046483_2_1_7"/>
    <dbReference type="OMA" id="QWKINGR"/>
    <dbReference type="OrthoDB" id="1766414at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00532_B">
        <property type="entry name" value="Ribosomal_S9_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023035">
        <property type="entry name" value="Ribosomal_S9_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_S9_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="PTHR21569"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="14380" checksum="5910489613AC2181" modified="2005-11-22" version="1">MAAISYYGTGKRKSSVARVWLKPGTGNIVINNKSIDDYFGRETSKMVVKQPLELVEKVGNFDIYVNVRGGGDSGQAGAIKHGITKALLEVDVALRGTLKKAGFITRDSRIKERKKYGKRAARRSCQFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y57</accession>
    <name>Q39Y57_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512271.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0574"/>
    <dbReference type="EnsemblBacteria" id="ABB30817">
        <property type="protein sequence ID" value="ABB30817"/>
        <property type="gene ID" value="Gmet_0574"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0574"/>
    <dbReference type="eggNOG" id="ENOG502ZG50">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1560746_0_0_7"/>
    <dbReference type="OMA" id="VTTHEHA"/>
    <dbReference type="OrthoDB" id="1964091at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223617" evidence="1">
        <location>
            <begin position="24"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="171" mass="19811" checksum="6F752403CE59F070" modified="2005-11-22" version="1">MIRKILVFALLCLLSAGCGRDSADVAQIKRGIARYNQLLVEGYKGLNMNYLQEVATPELATKAYYHMSAIGEGKLRMESALKELTFNRIELRRKDEAIVETREVWDFRYVEMKTGKTYYEEKDFVYEMGYTLKKHAEKWTITHITTISGKTGTTTVPWPEIKRNKDMTPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YB6</accession>
    <name>Q39YB6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_0515</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512211.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0515"/>
    <dbReference type="EnsemblBacteria" id="ABB30758">
        <property type="protein sequence ID" value="ABB30758"/>
        <property type="gene ID" value="Gmet_0515"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0515"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073293_0_0_7"/>
    <dbReference type="OMA" id="WSWADPV"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070161">
        <property type="term" value="C:anchoring junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026765">
        <property type="entry name" value="Tmem163"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31937">
        <property type="entry name" value="PTHR31937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0965">Cell junction</keyword>
    <keyword evidence="9" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="222" mass="24023" checksum="4DAD1280F7631F8F" modified="2005-11-22" version="1">MLCDKFLRLQELYRKAAILALITISYNIIEGIVSVWFGAADETLSLFGFGLDSFVEVISGVGIWHMVRRLRRGEEEKRDSFERRALRITGGAFYLLAAGLVVTAGLSIYGGHRPETTVWGIVVSLVSISFMWLLIRHKMKVGKALNSPAILADAACSRACLLLSVVLLAASAGYELTGIGYLDSLGSLAIAWLSFREGREAFDKADGMACSCSCACGAAEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YI7</accession>
    <name>Q39YI7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar hook-associated protein 2</fullName>
            <shortName evidence="5">HAP2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Flagellar cap protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fliD</name>
        <name evidence="8" type="ordered locus">Gmet_0444</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FliD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30687.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513812.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0444"/>
    <dbReference type="EnsemblBacteria" id="ABB30687">
        <property type="protein sequence ID" value="ABB30687"/>
        <property type="gene ID" value="Gmet_0444"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0444"/>
    <dbReference type="eggNOG" id="COG1345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015182_4_1_7"/>
    <dbReference type="OMA" id="TLEWQRD"/>
    <dbReference type="OrthoDB" id="883503at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009421">
        <property type="term" value="C:bacterial-type flagellum filament cap"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010810">
        <property type="entry name" value="Flagellin_hook_IN_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040026">
        <property type="entry name" value="FliD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010809">
        <property type="entry name" value="FliD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003481">
        <property type="entry name" value="FliD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30288">
        <property type="entry name" value="PTHR30288"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07196">
        <property type="entry name" value="Flagellin_IN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07195">
        <property type="entry name" value="FliD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02465">
        <property type="entry name" value="FliD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="FliD_N" evidence="6">
        <location>
            <begin position="11"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="FliD_C" evidence="7">
        <location>
            <begin position="221"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="416"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30687.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="472" mass="49724" checksum="D5826B4FC05BD51D" modified="2012-10-31" version="2">MANISISGLVTGLDSSSIISQLMQLERTPERIMKAKQQKYQNQISEFQKIETALKSFQKVVKGFNTLGNFKSMQTTVADNSVLTASGSSTATPGTHTVQVTTLAKNQRQVSMGVASQTDKVFNTGSFTITDSAGKTTTVSIAEGQNSLGDIVSAINTSGANVTASIINDGSPTPYRLVVTGKDTNNYTLDFSGLTTPPAGGTGSLLPTMLGPSDPSYQAGTAATLVVDGITMTKTSNTVTDAIQGITLNLLKEGSTTTVNVANDTSAVTNKINEFISSYNDVINLVNKQSIYNPDTKTAGVLSGDSTVRTIQSKLQSLLSTTVSGVTGPYTSLASLGITSDKKDGTLSVDSTALSSALSTNFEAVADLFTHNTGTYTTLPSNQYGIAQQFNLAIDSMVSPYIGTGVSTNGLIETRIKGLNTSISDINDQIDSLESRIEKMQSNLQLQFTNMETTVSKLQTQGNSLLSYLSKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YM7</accession>
    <name>RSMH_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.199</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA m(4)C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (cytosine-N(4)-)-methyltransferase RsmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmH</name>
        <name type="synonym">mraW</name>
        <name type="ordered locus">Gmet_0404</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = H(+) + N(4)-methylcytidine(1402) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10287"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74506"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.199"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RsmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.199" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512376.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YM7"/>
    <dbReference type="SMR" id="Q39YM7"/>
    <dbReference type="STRING" id="269799.Gmet_0404"/>
    <dbReference type="EnsemblBacteria" id="ABB30647">
        <property type="protein sequence ID" value="ABB30647"/>
        <property type="gene ID" value="Gmet_0404"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0404"/>
    <dbReference type="eggNOG" id="COG0275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038422_0_0_7"/>
    <dbReference type="OMA" id="NPAKRTF"/>
    <dbReference type="OrthoDB" id="1272633at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071424">
        <property type="term" value="F:rRNA (cytosine-N4-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01007">
        <property type="entry name" value="16SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002903">
        <property type="entry name" value="RsmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023397">
        <property type="entry name" value="SAM-dep_MeTrfase_MraW_recog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11265">
        <property type="entry name" value="PTHR11265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01795">
        <property type="entry name" value="Methyltransf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004486">
        <property type="entry name" value="MraW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81799">
        <property type="entry name" value="SSF81799"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00006">
        <property type="entry name" value="TIGR00006"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000386911" description="Ribosomal RNA small subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01007"/>
        </source>
    </evidence>
    <sequence length="313" mass="33839" checksum="7DF3EE18D4943753" modified="2005-11-22" version="1">MAEFGHLSVMPAEVLALLSPRPGGVYVDGTLGGAGHARMILEASSPDGVLVGFDRDPEALAAASKRIASFGDRVRLVRSNFAAMDESLATLGIDTIDGFLLDLGVSSHQLDTAERGFSFQVDAPLDMRMDPETGETAADLVNELSADELARIIREYGEERWAKRIASFVVKAREQHGPIESTLQLVDCVKGAIPRAAWEERIHPATRTFQALRIAVNDELGSLERGLVAGIERLAPGGRGVVISFHSLEDRIVKTVFRRYAQGCTCPKMLPRCVCGNKPRVRILTGKPVMAGGDEVATNPRARSAKVRAVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z00</accession>
    <name>Q39Z00_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type VI secretion system needle sheath protein TssC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tssC</name>
        <name evidence="3" type="ordered locus">Gmet_0279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513596.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0279"/>
    <dbReference type="EnsemblBacteria" id="ABB30524">
        <property type="protein sequence ID" value="ABB30524"/>
        <property type="gene ID" value="Gmet_0279"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0279"/>
    <dbReference type="eggNOG" id="COG3517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018386_1_0_7"/>
    <dbReference type="OMA" id="MSHAPFL"/>
    <dbReference type="OrthoDB" id="683477at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010269">
        <property type="entry name" value="T6SS_TssC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044032">
        <property type="entry name" value="TssC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044031">
        <property type="entry name" value="TssC1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35565">
        <property type="entry name" value="PTHR35565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05943">
        <property type="entry name" value="VipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18945">
        <property type="entry name" value="VipB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03355">
        <property type="entry name" value="VI_chp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VipB" evidence="1">
        <location>
            <begin position="66"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="VipB_2" evidence="2">
        <location>
            <begin position="378"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="492" mass="55420" checksum="382B519DC716FE9B" modified="2005-11-22" version="1">MSVEQQNTAAVESRIEGSLLEEIVQATKLQPADEAYSITKKGVEALITQLLEPGTETPKVSKAVLDDMIAEIDKKLSRQMDEILHNTQFQKLESSWRSLHFLVDRTDFRENNRIEIMNATKDELLDDFEDAPEVAKSGLYKTVYSAEYGQFGGKPYGAIIGNYDFGPGPQDIKLLQSLAAVSGMAHAPFIAAASPQFFGCDDYTALPNLKDIKSILEGPQYAKWQSFRESEDARYVGLALPRFLLRLPYGEATKPVKSFNYEESVSAGHDRYCWGNAAFSFATRLTESFANFRWCANIIGPQGGGAVHDLPLHQYEAMGAIQTKIPTEVLVSERREFELAEEGFIALTMRKGSDNAAFFSANSVQKPKYFGTSKEGKEAELNYKLGLQLPYMFIVSRLAHYLKVIQREHIGTWKERGDLENELNLWIRQYVSEMDNPMPGVRSRRPLRQAQVTVEEVPGEPGWYRVGLKVTPHFKYMGAYFTLSLVGKLDKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z16</accession>
    <name>Q39Z16_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase or acyltransferase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513580.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0263"/>
    <dbReference type="ESTHER" id="geomg-q39z16">
        <property type="family name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30508">
        <property type="protein sequence ID" value="ABB30508"/>
        <property type="gene ID" value="Gmet_0263"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0263"/>
    <dbReference type="eggNOG" id="COG2267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_1_7"/>
    <dbReference type="OMA" id="ESYLMHD"/>
    <dbReference type="OrthoDB" id="1196738at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="21"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="266" mass="28082" checksum="0ABC54D6144D6939" modified="2005-11-22" version="1">MNTIINGITLAYDDHGSGPAVVLVHGFPLCRRMWHPQIKAVTDAGFRLVTLDLRGFGESDAPEGPYSMELFADDVAGLLDYLGINRAVVGGMSMGGYVLFNLVERHAGRLAGAVFITTRATADDEAAKARRLQLAQETMKFGPQIIADAFVPLLFAEESLTGRPKLVEEVGGWIVGTDSRGLAGGLLAMRERKDYSGLLGTVGIPSLAIGAEGDRAAPPETARAIAAGIPGCRLEIVTEAGHMANLEHPGAFNDALVGFLKGLGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z55</accession>
    <name>Q39Z55_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0224</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512814.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0224"/>
    <dbReference type="EnsemblBacteria" id="ABB30469">
        <property type="protein sequence ID" value="ABB30469"/>
        <property type="gene ID" value="Gmet_0224"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0224"/>
    <dbReference type="eggNOG" id="COG3153">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081840_3_2_7"/>
    <dbReference type="OMA" id="HEWVCIH"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="174" mass="19420" checksum="6CEA88560755A0CB" modified="2005-11-22" version="1">MKIQRLTTENRPKVYALLRGAFPSSDYEAALVQKLHDNGRVIHEWVCIHTGKAIAYIAFTNAYHGRDICGLHLAPMAVAPEFQGRGVGSELLRFALRQEAISSQPLFVLGEPGYYSRFGFEPCRVPICPFDKNNAHFLSMRNATATSFVVGYEPEFTTAAAPTGTTRSRKRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z71</accession>
    <name>Q39Z71_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase, type 15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512796.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0207"/>
    <dbReference type="DNASU" id="3739669"/>
    <dbReference type="EnsemblBacteria" id="ABB30453">
        <property type="protein sequence ID" value="ABB30453"/>
        <property type="gene ID" value="Gmet_0207"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0207"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_31_0_7"/>
    <dbReference type="OMA" id="RCTPLYC"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="16846" checksum="E8A5EBDA2764B5A4" modified="2005-11-22" version="1">MTKKTFKKDHIVTSVVAVIVDDDGQVLLTKRNVSPFKGEWVMPGGKIDLGEPIIKALQREVMEEVGLQVEVEDLVDVFEHVTPGEDNYHFIILYYLCHPLYCDINHNLDEVEEARWVPRGELINYKMPQGARFILGKIFPELCSCET</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZA0</accession>
    <name>Q39ZA0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Transketolase</fullName>
            <ecNumber evidence="3 8">2.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tkt</name>
        <name evidence="10" type="ordered locus">Gmet_0178</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = aldehydo-D-ribose 5-phosphate + D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10508"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="8">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the transketolase family.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.1" evidence="3 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512765.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0178"/>
    <dbReference type="EnsemblBacteria" id="ABB30424">
        <property type="protein sequence ID" value="ABB30424"/>
        <property type="gene ID" value="Gmet_0178"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0178"/>
    <dbReference type="eggNOG" id="COG0021">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_0_0_7"/>
    <dbReference type="OMA" id="HHTEGIE"/>
    <dbReference type="OrthoDB" id="188169at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004802">
        <property type="term" value="F:transketolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005478">
        <property type="entry name" value="Transketolase_bac-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020826">
        <property type="entry name" value="Transketolase_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033247">
        <property type="entry name" value="Transketolase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43522">
        <property type="entry name" value="PTHR43522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00232">
        <property type="entry name" value="tktlase_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00802">
        <property type="entry name" value="TRANSKETOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="668" mass="72304" checksum="2DE8DA8477D217E3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZB9</accession>
    <name>Q39ZB9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0158</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512745.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0158"/>
    <dbReference type="EnsemblBacteria" id="ABB30405">
        <property type="protein sequence ID" value="ABB30405"/>
        <property type="gene ID" value="Gmet_0158"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0158"/>
    <dbReference type="HOGENOM" id="CLU_1254442_0_0_7"/>
    <dbReference type="OMA" id="FNAWDCF"/>
    <dbReference type="OrthoDB" id="1539186at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="189" mass="20524" checksum="DA0B2DF3D7E347DA" modified="2005-11-22" version="1">MAPPVDDFGGLVTRATRLWTGNFGNLLILSLVFVLVCWIPVANVGFLAGYTRAILKVARGEKAEAGDIFRAWDCFGDLFVYLLLVLVAQFALNHVPGIGQVAGFALAVVVAPGMYGIIDRRMKFMDAFRWSLEAIKGDLVGWLLAVLIGGIFMAVGALLLGIGIIITLGWGSLVMALQYDRERPRVIIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZH1</accession>
    <name>Q39ZH1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="synonym">glmS-1</name>
        <name evidence="11" type="ordered locus">Gmet_0104</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514109.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0104"/>
    <dbReference type="EnsemblBacteria" id="ABB30353">
        <property type="protein sequence ID" value="ABB30353"/>
        <property type="gene ID" value="Gmet_0104"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0104"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_7"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="43416at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="286"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="458"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="609" mass="66634" checksum="17DE6BD8B6B985F5" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZM8</accession>
    <name>Q39ZM8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase of ISGme8, IS110 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0045</name>
        <name evidence="3" type="ordered locus">Gmet_0046</name>
        <name evidence="4" type="ordered locus">Gmet_0094</name>
        <name evidence="5" type="ordered locus">Gmet_0132</name>
        <name evidence="6" type="ordered locus">Gmet_0488</name>
        <name evidence="7" type="ordered locus">Gmet_0670</name>
        <name evidence="8" type="ordered locus">Gmet_0723</name>
        <name evidence="9" type="ordered locus">Gmet_0958</name>
        <name evidence="10" type="ordered locus">Gmet_1143</name>
        <name evidence="11" type="ordered locus">Gmet_1718</name>
        <name evidence="12" type="ordered locus">Gmet_2073</name>
        <name evidence="13" type="ordered locus">Gmet_2810</name>
        <name evidence="14" type="ordered locus">Gmet_2975</name>
        <name evidence="15" type="ordered locus">Gmet_3429</name>
    </gene>
    <organism evidence="3 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513407.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="DNASU" id="3739420"/>
    <dbReference type="EnsemblBacteria" id="ABB30295">
        <property type="protein sequence ID" value="ABB30295"/>
        <property type="gene ID" value="Gmet_0045"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30296">
        <property type="protein sequence ID" value="ABB30296"/>
        <property type="gene ID" value="Gmet_0046"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30343">
        <property type="protein sequence ID" value="ABB30343"/>
        <property type="gene ID" value="Gmet_0094"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30381">
        <property type="protein sequence ID" value="ABB30381"/>
        <property type="gene ID" value="Gmet_0132"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30731">
        <property type="protein sequence ID" value="ABB30731"/>
        <property type="gene ID" value="Gmet_0488"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30912">
        <property type="protein sequence ID" value="ABB30912"/>
        <property type="gene ID" value="Gmet_0670"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30965">
        <property type="protein sequence ID" value="ABB30965"/>
        <property type="gene ID" value="Gmet_0723"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31200">
        <property type="protein sequence ID" value="ABB31200"/>
        <property type="gene ID" value="Gmet_0958"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31381">
        <property type="protein sequence ID" value="ABB31381"/>
        <property type="gene ID" value="Gmet_1143"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31949">
        <property type="protein sequence ID" value="ABB31949"/>
        <property type="gene ID" value="Gmet_1718"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32302">
        <property type="protein sequence ID" value="ABB32302"/>
        <property type="gene ID" value="Gmet_2073"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33028">
        <property type="protein sequence ID" value="ABB33028"/>
        <property type="gene ID" value="Gmet_2810"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33190">
        <property type="protein sequence ID" value="ABB33190"/>
        <property type="gene ID" value="Gmet_2975"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33641">
        <property type="protein sequence ID" value="ABB33641"/>
        <property type="gene ID" value="Gmet_3429"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0045"/>
    <dbReference type="KEGG" id="gme:Gmet_0046"/>
    <dbReference type="KEGG" id="gme:Gmet_0094"/>
    <dbReference type="KEGG" id="gme:Gmet_0132"/>
    <dbReference type="KEGG" id="gme:Gmet_0488"/>
    <dbReference type="KEGG" id="gme:Gmet_0670"/>
    <dbReference type="KEGG" id="gme:Gmet_0723"/>
    <dbReference type="KEGG" id="gme:Gmet_0958"/>
    <dbReference type="KEGG" id="gme:Gmet_1143"/>
    <dbReference type="KEGG" id="gme:Gmet_1718"/>
    <dbReference type="KEGG" id="gme:Gmet_2073"/>
    <dbReference type="KEGG" id="gme:Gmet_2810"/>
    <dbReference type="KEGG" id="gme:Gmet_2975"/>
    <dbReference type="KEGG" id="gme:Gmet_3429"/>
    <dbReference type="eggNOG" id="COG3547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036902_5_1_7"/>
    <dbReference type="OMA" id="KGHINRN"/>
    <dbReference type="OrthoDB" id="655500at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003346">
        <property type="entry name" value="Transposase_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002525">
        <property type="entry name" value="Transposase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01548">
        <property type="entry name" value="DEDD_Tnp_IS110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02371">
        <property type="entry name" value="Transposase_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEDD_Tnp_IS110" evidence="1">
        <location>
            <begin position="8"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB33028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB33190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB33641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="318" mass="34631" checksum="6F969C5C43DB6DFA" modified="2005-11-22" version="1">MEPNDAVVGVDVSKEHLDVYLMPTGDQKRVTNDDAGCAELTTWLITNAPCRIVLEATGGLEMLAVSTLSAAGLPVVVVNPRQVRNFAKACGLLAKTDILDAKIIARFAQAIKPEIRPLKDETSQNLAALLARRRQLVEMLVAEKNRVISAAPTVRKGIMTHIAWLTQQIDDVDKDISTLIQSSESWKAKEEILTSVKGIGPVTAATILAALPELGTISRQQLGALVGVCPYNRDSGKFRGKRAISGGRATVRSVLYMATLCAARFNPVIKAFYQRLTSAGKLHKVAITACMRKLLTILNAMVKNNQKWDHSKFTPLLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-09-29" version="41" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEN7</accession>
    <name>J9JEN7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366031.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2278"/>
    <dbReference type="EnsemblBacteria" id="AFR42834">
        <property type="protein sequence ID" value="AFR42834"/>
        <property type="gene ID" value="Gmet_2278"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2278"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_628157_0_0_7"/>
    <dbReference type="OMA" id="NDACDHY"/>
    <dbReference type="OrthoDB" id="785253at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022000">
        <property type="entry name" value="Min27-like_integrase_DNA_bind"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12167">
        <property type="entry name" value="Arm-DNA-bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14659">
        <property type="entry name" value="Phage_int_SAM_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="211"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFR42834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="436" mass="50811" checksum="27C9598B2805E817" modified="2012-10-31" version="1">MRMKKGMLALEEPVKQIGAIKRRKESKKLYVDFYYFGRRITRSTELNDTPANERKVRAFLDKVMQRIEDGTFKFAEAFLGATEEEKEFFTQLEGREYRPEPHQVVFGEYVKEWMATIFPTFGSPTKRRDYREAIETRILPAFRNMTFHQITGMAVFRFTESLVWKKGIHKGKPLSTARKSNILIPFRSIWNDACDHYRWVIKSPFDNLRKRLPKTEKKEHTVIRFADWLTFLDNLEVHYRPIAELMILTGMIPSELGGLRKDDIEGNYLNVRNSYVLGVEKKSLKTAFRKRQISITEAIRKRLQELQNRPGSPYLCTMVDGSRFNSSRFCKVWKKAVDQAGIPYVTSYSARHSFAAWSLIIGVNPLRLVKLMGHASKQMVYEVYGNYVEGLEEDAENIFRYFGRDFIIPGKSKSPIPFRDSTGDSFANNLLTFGDC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PQ9</accession>
    <name>MNME_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA modification GTPase MnmE</fullName>
            <ecNumber evidence="1">3.6.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmE</name>
        <name evidence="1" type="synonym">trmE</name>
        <name type="ordered locus">Gmet_3560</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513716.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39PQ9"/>
    <dbReference type="SMR" id="Q39PQ9"/>
    <dbReference type="STRING" id="269799.Gmet_3560"/>
    <dbReference type="EnsemblBacteria" id="ABB33765">
        <property type="protein sequence ID" value="ABB33765"/>
        <property type="gene ID" value="Gmet_3560"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3560"/>
    <dbReference type="eggNOG" id="COG0486">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019624_4_1_7"/>
    <dbReference type="OMA" id="CEIQCHG"/>
    <dbReference type="OrthoDB" id="263682at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04164">
        <property type="entry name" value="trmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00379">
        <property type="entry name" value="GTPase_MnmE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031168">
        <property type="entry name" value="G_TrmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018948">
        <property type="entry name" value="GTP-bd_TrmE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004520">
        <property type="entry name" value="GTPase_MnmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027368">
        <property type="entry name" value="MnmE_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025867">
        <property type="entry name" value="MnmE_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT_dom1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12631">
        <property type="entry name" value="MnmE_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10396">
        <property type="entry name" value="TrmE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00450">
        <property type="entry name" value="mnmE_trmE_thdF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51709">
        <property type="entry name" value="G_TRME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000345789" description="tRNA modification GTPase MnmE">
        <location>
            <begin position="1"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="TrmE-type G">
        <location>
            <begin position="221"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="231"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="250"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="275"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>(6S)-5-formyl-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57457"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00379"/>
        </source>
    </evidence>
    <sequence length="457" mass="50167" checksum="03F2D1ACF7043316" modified="2005-11-22" version="1">MYLEDTIAAIGTPVGEGGIGIIRVSGPDVPAIARRIVRRVNENGDFVSHRFYYGTVVDPESRDTVDEVMAVLMRAPRSFTREDVLEIQCHGGYLVTRRVLDAVLQCGARPAEPGEFTRRAFLNGRIDLVQAEAVIDVIRSKTEAALNLAQHQREGRLSERLKAVQGCLRHSLALVEAFIDFPDDEVDPASRVEIEAKAREASGRIEELLEGFDEGRVLRDGVSVLIAGKPNVGKSSLLNTLLQEKRAIVTSVPGTTRDIIEEVVNVRGLPLRMLDTAGIRETEDVVEQEGVRLTLEKIPQADLILFVLDGSRPFDDDDRMILAALAERRVIVVTNKSDLPVTLRIPGELEGVHTVAISTATGAGIDDLREAVFETFIHGRAIDSREYVALSQTRHRDALVKARGRIAVFFANLAAGNDLEILAVDLRDALDAVGEVTGETTPDDILELIFQRFCIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PS7</accession>
    <name>Q39PS7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cell division coordinator CpoB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cpoB</name>
        <name evidence="3" type="ordered locus">Gmet_3542</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CpoB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513698.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3542"/>
    <dbReference type="EnsemblBacteria" id="ABB33747">
        <property type="protein sequence ID" value="ABB33747"/>
        <property type="gene ID" value="Gmet_3542"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3542"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044315_3_0_7"/>
    <dbReference type="OMA" id="IDMLTQN"/>
    <dbReference type="OrthoDB" id="1099900at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02066">
        <property type="entry name" value="CpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034706">
        <property type="entry name" value="CpoB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014162">
        <property type="entry name" value="CpoB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02795">
        <property type="entry name" value="tol_pal_ybgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0574">Periplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009992531" description="Cell division coordinator CpoB" evidence="1">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="150"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="187"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="271" mass="30477" checksum="D49DD38049987FCF" modified="2005-11-22" version="1" precursor="true">MNIVRNISLVVLLALSGCAMRSDLETVQRDNEELKTRIFRLEKDLGGVRTETRAGIETTLQDFEKERAGARKGLADLQASMDAMKVDLQVMAGKVDDLSLAAKKPTEEVNLLKEDLERRLSSLEERLGAVQKKVTDMETAQAKPPEPATPEALYQKGLDAYRSGNFAAARESFARFLEQHPKHELAVNAHYWSGEAYYGEKKYEQAILEFQEVIKNFPGKEKVPAAMLKQAGAFNEIGDVKSARYVLRKLIDEHPSTEEARRAKERLKALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PW1</accession>
    <name>Q39PW1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux pump, RND family, membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513664.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3508"/>
    <dbReference type="EnsemblBacteria" id="ABB33713">
        <property type="protein sequence ID" value="ABB33713"/>
        <property type="gene ID" value="Gmet_3508"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3508"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_13_3_7"/>
    <dbReference type="OMA" id="SYPKQTF"/>
    <dbReference type="OrthoDB" id="1174564at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="96"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="424" mass="45398" checksum="B5A1057C186FFC14" modified="2005-11-22" version="1">MNRKNGIIIGIILAMAVGGAFVYRSTHVKGGAGEHAETKEAGHTDEKGGHEEGKHEGEKEGHEGHDEHGEEGTIKMTAEVQKQNGVAVAPAQKQRLAGAISATGKVEANADRIAHVSPRISGKIVSVRASLGDGVAAGQPLVTLDSVELGEALNRYHQSKTRLALAQSNMDRIKALVEKKIAARKDILQAETDYKMAQTELHTDEERLSLYGVSTSDLGKANHRKPLLPVRSPIGGIITEKHAIVGELADPSKSLYTVADLSSVWVMVDINEKDLVKIHRGQTAAVTVSAFPDLKLKGRITYIADLVDESTRTVKARVEVANPGRKLKPEMFATIELTLAADAPPVLAVPEDALQDLDGKKVLFIAEKDSEFAARPVQTGRAAGGLVEIVSGLKEGENYAVKGSFILKSEIKKGEMTDEHGHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q05</accession>
    <name>Q39Q05_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybhR-2</name>
        <name evidence="7" type="ordered locus">Gmet_3460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513911.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3460"/>
    <dbReference type="EnsemblBacteria" id="ABB33669">
        <property type="protein sequence ID" value="ABB33669"/>
        <property type="gene ID" value="Gmet_3460"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3460"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_8_3_7"/>
    <dbReference type="OMA" id="AHARYNP"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="373" mass="41523" checksum="BD7E4EECFF0EAE5E" modified="2005-11-22" version="1">MFERIREMVIKEFSQVFRDRRMKAIIFVTPILQLLMFGYAVTTDVKNITTAVYDLDRSYESRELARRLESSGYFTITSTPASPEELGELIDRGKVLAAVQVNRGFGRDLARGIPTEVQVIVDGTDSNTASVAMDYATRVIARFGKDMGSRAMTRPLAKTGRVDLRPRAWYNPDLRSRNYNVPGVIAIIIMLTSLLLTAMAVVREREIGTMEQLMVTPLKPVELILGKTIPFAVISFFDMALVTTVGVFWFGIPIKGSLPLLTLATGIYLLSVLGIGLFISTISRTQQQALMATFLFYIPAVLLSGFMFPIENMPEAIQYGTFLNPLRYFLVIIRGIFLKGNGIGVLWPQLAALLALGVAVMSLSALRFRKRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q17</accession>
    <name>Q39Q17_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NUDIX hydrolase, coenzyme A pyrophosphatase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3448</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513900.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3448"/>
    <dbReference type="EnsemblBacteria" id="ABB33657">
        <property type="protein sequence ID" value="ABB33657"/>
        <property type="gene ID" value="Gmet_3448"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3448"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_5_3_7"/>
    <dbReference type="OMA" id="YWSGQIG"/>
    <dbReference type="OrthoDB" id="1623169at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="205" mass="23069" checksum="2545222BEBB94D71" modified="2005-11-22" version="1">MKQAQDISTALNSHPVRIIEPGKRAHAAVALILEEQPDGPNILFIQRSTDECDYWSGQIGFPGGRAEPGDKGPQETAERETREEIGLDLGTATYLGRLNDLVPGGLQIVISCFVYAVDRQPILNLDRTEIARAFWLSVRELNNPARLTRVEFIGRRRQRRFPALRLGDGTEQPLWGITYRLLRNLDKILRGAGKQVRSTCKEQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q41</accession>
    <name>Q39Q41_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleoid-associated protein Gmet_3421</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the YbaB/EbfC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514228.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3421"/>
    <dbReference type="EnsemblBacteria" id="ABB33633">
        <property type="protein sequence ID" value="ABB33633"/>
        <property type="gene ID" value="Gmet_3421"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3421"/>
    <dbReference type="eggNOG" id="COG0718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140930_1_0_7"/>
    <dbReference type="OMA" id="MGNMMKQ"/>
    <dbReference type="OrthoDB" id="1883809at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043590">
        <property type="term" value="C:bacterial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1310.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00274">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036894">
        <property type="entry name" value="YbaB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004401">
        <property type="entry name" value="YbaB/EbfC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33449">
        <property type="entry name" value="PTHR33449"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02575">
        <property type="entry name" value="YbaB_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004555">
        <property type="entry name" value="UCP004555"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82607">
        <property type="entry name" value="SSF82607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00103">
        <property type="entry name" value="DNA_YbaB_EbfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="5"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="104" mass="10917" checksum="80ACFFB51EE0E576" modified="2005-11-22" version="1">MSKGLAGIMKQAQMMQQKMAKLQEEAAQQTAEATAGGGAVTAVVTGKNQLVSLTIKPEAVDPNDVEMLQDLIVAAVNEALKKVQSKFSEEMGKITGGLNIPGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q46</accession>
    <name>Q39Q46_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_3416</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514223.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3416"/>
    <dbReference type="EnsemblBacteria" id="ABB33628">
        <property type="protein sequence ID" value="ABB33628"/>
        <property type="gene ID" value="Gmet_3416"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3416"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_4_7"/>
    <dbReference type="OMA" id="MSVMMAT"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="44"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="361"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="394"/>
            <end position="401"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="602" mass="66921" checksum="5E780A200B3A76E6" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QD0</accession>
    <name>Q39QD0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmically oriented, membrane-bound [NiFe]-hydrogenase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hyaL</name>
        <name evidence="5" type="ordered locus">Gmet_3331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512555.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3331"/>
    <dbReference type="EnsemblBacteria" id="ABB33544">
        <property type="protein sequence ID" value="ABB33544"/>
        <property type="gene ID" value="Gmet_3331"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3331"/>
    <dbReference type="eggNOG" id="COG0374">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030087_0_0_7"/>
    <dbReference type="OMA" id="EEVTHSW"/>
    <dbReference type="OrthoDB" id="1967820at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00507">
        <property type="entry name" value="NI_HGENASE_L_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="566" mass="62281" checksum="13A17086A00C8A85" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QD1</accession>
    <name>Q39QD1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Periplasmically oriented, membrane-bound [NiFe]-hydrogenase, cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hyaB</name>
        <name evidence="6" type="ordered locus">Gmet_3330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HupC/HyaC/HydC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512554.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3330"/>
    <dbReference type="EnsemblBacteria" id="ABB33543">
        <property type="protein sequence ID" value="ABB33543"/>
        <property type="gene ID" value="Gmet_3330"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3330"/>
    <dbReference type="eggNOG" id="COG1969">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075520_0_0_7"/>
    <dbReference type="OMA" id="HIYSAWL"/>
    <dbReference type="OrthoDB" id="923657at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011577">
        <property type="entry name" value="Cyt_b561_bac/Ni-Hgenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000516">
        <property type="entry name" value="Ni-dep_Hydgase_cyt-B"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01292">
        <property type="entry name" value="Ni_hydr_CYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00161">
        <property type="entry name" value="NIHGNASECYTB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02125">
        <property type="entry name" value="CytB-hydogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00882">
        <property type="entry name" value="NI_HGENASE_CYTB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Ni_hydr_CYTB" evidence="5">
        <location>
            <begin position="13"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="222" mass="25102" checksum="E50B3374B53FA8E8" modified="2005-11-22" version="1">MARNRSCLYEKYVWEVPVRLTHWVNVIAIIVLSVTGFYIGSPRTLGLVPADFVMGWVRVVHLTAGYAFAVSIVSRIWWAFAGNRYAGWREFVPFIYPEGRRDMGRMFLYYVFLSRKVPHPTGHNALAGATYLLVFVLYLVMAGTGFALDAEHAPGGLAHVLLTPLYALFSNQGMRLTHHMGMWLLIAFAIHHIYSAWLMDVKERGGVMSSIFGGYKPVKRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QG8</accession>
    <name>Q39QG8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="4">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_3293</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(3S)-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512517.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3293"/>
    <dbReference type="EnsemblBacteria" id="ABB33506">
        <property type="protein sequence ID" value="ABB33506"/>
        <property type="gene ID" value="Gmet_3293"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3293"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022138_3_2_7"/>
    <dbReference type="OMA" id="FHNTRGT"/>
    <dbReference type="OrthoDB" id="1111394at2"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000138">
        <property type="entry name" value="HMG_CoA_lyase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="PTHR42738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01062">
        <property type="entry name" value="HMG_COA_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="6">
        <location>
            <begin position="7"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="309" mass="32232" checksum="5E3B1951F2971CF5" modified="2005-11-22" version="1">MPMPTRVKMVEVGPRDGLQNEKAIIPAEVKIALIDKLSEAGLPAIEVTSFVSPTWVPQMADNAQVMTGIARREGVAYPVLVPNRKGLEAAIAAGAAEIAIFAAASESFSRKNINCSIAESLERFAEVITVARVQGLRVRGYVSCVLGCPYEGEVSFDVVAGVAGQLLQLGCYEISLGDTIGVGTPGRAQTMVDVVSRLVPREKLAVHFHDTYGQALANILAVLERGIATVDSSVAGLGGCPYAAGASGNVASEDLLYMLNGLGIETGVDLEHLMAAGNYISGHLGRPSGSRVARAMGCSPHQITTTANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QH4</accession>
    <name>Q39QH4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512510.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3287"/>
    <dbReference type="EnsemblBacteria" id="ABB33500">
        <property type="protein sequence ID" value="ABB33500"/>
        <property type="gene ID" value="Gmet_3287"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3287"/>
    <dbReference type="eggNOG" id="COG3162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123372_3_1_7"/>
    <dbReference type="OMA" id="AKMRFLV"/>
    <dbReference type="OrthoDB" id="1906817at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="102" mass="11640" checksum="A2B7804B2C45D40D" modified="2005-11-22" version="1">MAADQHNWTKIANHPRFVELHRKKMVFLYGWWAFSAGFYFLLLLGAGYTPGFFGLEIIGNINVGYLLALAQFVVSFGIAIHYGRVADRDFDRLTQELVKQIG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QP4</accession>
    <name>TATA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tatA</name>
        <name type="ordered locus">Gmet_3217</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512655.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QP4"/>
    <dbReference type="SMR" id="Q39QP4"/>
    <dbReference type="STRING" id="269799.Gmet_3217"/>
    <dbReference type="EnsemblBacteria" id="ABB33430">
        <property type="protein sequence ID" value="ABB33430"/>
        <property type="gene ID" value="Gmet_3217"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3217"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_6_0_7"/>
    <dbReference type="OMA" id="IKPQKKD"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000044388" description="Sec-independent protein translocase protein TatA">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <sequence length="61" mass="6566" checksum="9BAAEBDBF1402709" modified="2005-11-22" version="1">MFGIGMPELIVILVIVLVVFGAGRLPEIGGALGKSIRNFKKASDGKDEIEIKPEKKDDPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QQ1</accession>
    <name>Q39QQ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphoaspartate phosphatase CheC associated with MCPs of class 44H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheC44H</name>
        <name evidence="3" type="ordered locus">Gmet_3210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512648.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3210"/>
    <dbReference type="EnsemblBacteria" id="ABB33423">
        <property type="protein sequence ID" value="ABB33423"/>
        <property type="gene ID" value="Gmet_3210"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3210"/>
    <dbReference type="eggNOG" id="COG1776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087860_2_0_7"/>
    <dbReference type="OMA" id="LYIETEI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007597">
        <property type="entry name" value="CheC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04509">
        <property type="entry name" value="CheC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="9"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="CheC" evidence="2">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="204" mass="21924" checksum="49D3FAD6FC86BE93" modified="2005-11-22" version="1">MKFDALTEEHLDALREVSNIGVAHAATALSQLIGRSISLTVPKVLLTEICKVPEVFGGAEKLVVGIYLQMLGDARGNILIVLPRDSALKLLSRLLPREKSEGTLLTELEISALKEVGNILASAYLNALGALMGKTLIPSVPVLSFDMVGAVIDYALIELGEIGDLALMVETDFFGEEEKINGQFFLLPDPESLKIILNAIGVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QY0</accession>
    <name>Q39QY0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2062 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514305.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3130"/>
    <dbReference type="EnsemblBacteria" id="ABB33344">
        <property type="protein sequence ID" value="ABB33344"/>
        <property type="gene ID" value="Gmet_3130"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3130"/>
    <dbReference type="eggNOG" id="COG3216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102912_1_2_7"/>
    <dbReference type="OMA" id="GCFPFFG"/>
    <dbReference type="OrthoDB" id="1672574at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018639">
        <property type="entry name" value="DUF2062"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09835">
        <property type="entry name" value="DUF2062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2062" evidence="2">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="17799" checksum="E0AE45EFF26CB370" modified="2005-11-22" version="1">MLDKEKWKKNFRAILSLDSHPGHIAAGLAVGVFISFTPFFTFHTVLAIAAAFIFRLNKLTCITGAWVNTPFTVVPILAASYKLGRVVRGLPPQEFHFKGLHWAYLKSHAATLIVGTSLLGFAAALVSYALCYWLVVRFRKKDETLATLADEMEEVGEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R52</accession>
    <name>Q39R52_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integration host factor subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">ihfA-3</name>
        <name evidence="9" type="ordered locus">Gmet_3057</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513617.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3057"/>
    <dbReference type="EnsemblBacteria" id="ABB33272">
        <property type="protein sequence ID" value="ABB33272"/>
        <property type="gene ID" value="Gmet_3057"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3057"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_1_3_7"/>
    <dbReference type="OMA" id="QERISCQ"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13835">
        <property type="entry name" value="IHF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005684">
        <property type="entry name" value="IHF_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="97" mass="10711" checksum="A971D4B1D2550C63" modified="2005-11-22" version="1">MTKADLADKIQERISCQKKEAVELVELVMESLKDAIATEGLVKISGFGNFVVRQKTDRAGRNPQTGETITISSRKVLTFKPSVILKNRINSSLMSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RB8</accession>
    <name>Q39RB8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514482.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2991"/>
    <dbReference type="EnsemblBacteria" id="ABB33206">
        <property type="protein sequence ID" value="ABB33206"/>
        <property type="gene ID" value="Gmet_2991"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2991"/>
    <dbReference type="eggNOG" id="ENOG502ZHRQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2769996_0_0_7"/>
    <dbReference type="OMA" id="LEWYAYI"/>
    <dbReference type="OrthoDB" id="1992186at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="69" mass="8085" checksum="13A6EF3940D21AA8" modified="2005-11-22" version="1">MELKNKIWMTGNLDWFAYVGEEEMYLGRREVPSPLEEGDAWVNSIGDSFKVEDGEIKYLGRVEPPQTFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RC2</accession>
    <name>Q39RC2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Adenosine nucleotide alpha-hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514478.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2987"/>
    <dbReference type="EnsemblBacteria" id="ABB33202">
        <property type="protein sequence ID" value="ABB33202"/>
        <property type="gene ID" value="Gmet_2987"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2987"/>
    <dbReference type="eggNOG" id="COG1606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061181_2_0_7"/>
    <dbReference type="OMA" id="DKPAQPC"/>
    <dbReference type="OrthoDB" id="846643at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01990">
        <property type="entry name" value="Alpha_ANH_like_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005232">
        <property type="entry name" value="LarE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43169:SF2">
        <property type="entry name" value="PTHR43169:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006661">
        <property type="entry name" value="PP-lp_UCP006661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00268">
        <property type="entry name" value="TIGR00268"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile and sulfur donor" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR006661-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="280" mass="30672" checksum="AE3F1FF26313AF8F" modified="2005-11-22" version="1">MNDIHDKYEKLKAILREMGSVLVAFSGGVDSTFLLRVAHDVLGDRAVALTATSPTYPESEFREAVALALEIGVRQVVVESNELEIPGFAGNPRNRCYHCKKELFQLAGARAAGLGLSWAADGSNVDDLSDFRPGRQAIQELGVRSPLLEAGLGKEDIRQLSRELGLPTWNKQAFACLSSRFPYGTEITPERLRQVGECEEFLKGEGFFTYRVRYHGDTARIELGEAEIARFLEPAMRRKVAAFFKGAGFTYVALDLEGYRTGSMNLGTGDQGPGTGKTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RF9</accession>
    <name>Q39RF9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Dihydrofolate reductase</fullName>
            <ecNumber evidence="3 7">1.5.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">folA</name>
        <name evidence="10" type="ordered locus">Gmet_2947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the dihydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="3 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512883.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2947"/>
    <dbReference type="EnsemblBacteria" id="ABB33165">
        <property type="protein sequence ID" value="ABB33165"/>
        <property type="gene ID" value="Gmet_2947"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2947"/>
    <dbReference type="eggNOG" id="COG0262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043966_5_1_7"/>
    <dbReference type="OMA" id="RDNQLPW"/>
    <dbReference type="OrthoDB" id="1920912at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006545">
        <property type="term" value="P:glycine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012259">
        <property type="entry name" value="DHFR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48069">
        <property type="entry name" value="PTHR48069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000194">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="SSF53597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="5 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHFR" evidence="9">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="161" mass="17417" checksum="06CDD2420F803C1D" modified="2005-11-22" version="1">MIVTIIAAMAGNRVIGKEGAMPWHLPDDLARFKAITMGHPVVMGRKTFESIGRPLPGRLNIVLTRQAGYAPSGVTVARTLAEALILAGTAGEVFICGGGEVYREALPLADRIHLTVIHRAYGGDTTFPELPADFEETCREHGEGKPPHSFITFERRRGSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RG6</accession>
    <name>Q39RG6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 7">Pyruvate, phosphate dikinase</fullName>
            <ecNumber evidence="4 7">2.7.9.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ppdK</name>
        <name evidence="14" type="ordered locus">Gmet_2940</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP + phosphate + pyruvate = AMP + diphosphate + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10756"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.1" evidence="4 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512876.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2940"/>
    <dbReference type="EnsemblBacteria" id="ABB33158">
        <property type="protein sequence ID" value="ABB33158"/>
        <property type="gene ID" value="Gmet_2940"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2940"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015345_0_2_7"/>
    <dbReference type="OMA" id="RRFVQMY"/>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050242">
        <property type="term" value="F:pyruvate, phosphate dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010121">
        <property type="entry name" value="Pyruvate_phosphate_dikinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22931">
        <property type="entry name" value="PTHR22931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000853">
        <property type="entry name" value="PPDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01828">
        <property type="entry name" value="pyru_phos_dikin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="22"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="435"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="531"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="8">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="844"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="758"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="779"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="780"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="781"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9 10">
        <location>
            <position position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000853-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB33158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="888" mass="96616" checksum="B7B1C784D7CE51FC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RJ9</accession>
    <name>SELD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Selenide, water dikinase</fullName>
            <ecNumber evidence="2">2.7.9.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Selenium donor protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Selenophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">selD</name>
        <name type="ordered locus">Gmet_2907</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Synthesizes selenophosphate from selenide and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + H2O + hydrogenselenide = AMP + 2 H(+) + phosphate + selenophosphate</text>
            <dbReference type="Rhea" id="RHEA:18737"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:29317"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the selenophosphate synthase 1 family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2907"/>
    <dbReference type="KEGG" id="gme:Gmet_2907"/>
    <dbReference type="eggNOG" id="COG0709">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032859_0_1_7"/>
    <dbReference type="OMA" id="DNEPKYG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004756">
        <property type="term" value="F:selenide, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02195">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00625">
        <property type="entry name" value="SelD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023061">
        <property type="entry name" value="SelD_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004536">
        <property type="entry name" value="SPS/SelD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10256">
        <property type="entry name" value="PTHR10256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036407">
        <property type="entry name" value="Selenphspht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00476">
        <property type="entry name" value="selD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0711">Selenium</keyword>
    <keyword id="KW-0712">Selenocysteine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000318648" description="Selenide, water dikinase">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <begin position="44"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="135"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="2">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00625"/>
        </source>
    </evidence>
    <sequence length="343" mass="34985" checksum="876B476996BC4BFA" modified="2008-02-26" version="2">MIKLTSLVKAAGUAAKLGPAGLEDALSGILGKGDDPNLLVGPETADDAGVYRIGEGLALVDTVDIITPLVDDPFTFGRIAAANALSDVYAMGGRPVTAMNLAFFPACTLPGQILADIMAGGLDAVREAGACLVGGHTVEDHELKYGLSVTGLISPGRIVRNSTARPGDRLILTKPLGTGIVSTAIKADMVAPGVVDEAIRWMALLNASAAGLMLECEASACTDVTGFGLLGHACEMARGAGVTLEIALDAVPLMGGVEDLVADGLVPAGCYRNRDHYTPLVSVSAGAGGRLIPLFDPQTSGGLLITLSPQFADSFLSMARDRGLFAVAVGGVLPPREHAVVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RK7</accession>
    <name>Q39RK7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2899</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33117.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512835.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2899"/>
    <dbReference type="EnsemblBacteria" id="ABB33117">
        <property type="protein sequence ID" value="ABB33117"/>
        <property type="gene ID" value="Gmet_2899"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2899"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051321_0_0_7"/>
    <dbReference type="OMA" id="RSCKTCH"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010177">
        <property type="entry name" value="Paired_CXXCH_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09699">
        <property type="entry name" value="Paired_CXXCH_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01905">
        <property type="entry name" value="paired_CXXCH_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223200" evidence="1">
        <location>
            <begin position="26"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="2">
        <location>
            <begin position="51"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="2">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="2">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="2">
        <location>
            <begin position="193"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="2">
        <location>
            <begin position="271"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33117.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="336" mass="36464" checksum="9CF1A56DCD9D280C" modified="2012-10-31" version="2">MTASPLFLSVTAAAFWLLLTGGFAAASSLPGVPDGCNTRCHKSKVREAFVHGPVGSDDCISCHNPTGLEHPKQRGAFRLVAEGAKLCSVCHEGKADKKVVHPPVAKGACLDCHDVHQSPYRMQLKADGAALCFGCHDEEKFKATHRHAPVAEGSCLGCHDPHQSDNRALLKGSGAGLCFICHDKKMAEGVSIHGPVAAGGCTDCHAPHGSPFYKILKNAFPEQFYLPYAQENFALCFDCHTKDLAQDKRTDTITGFRNGDRNLHNLHINKPDKGRSCKTCHDPHAALQPRLIKERIPGFGTWEIPIRYTKTDTGGTCVAGCHKPKSYDRLRAVRNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RK8</accession>
    <name>Q39RK8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512834.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2898"/>
    <dbReference type="EnsemblBacteria" id="ABB33116">
        <property type="protein sequence ID" value="ABB33116"/>
        <property type="gene ID" value="Gmet_2898"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2898"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_852181_0_0_7"/>
    <dbReference type="OMA" id="CQMCHNK"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010177">
        <property type="entry name" value="Paired_CXXCH_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09699">
        <property type="entry name" value="Paired_CXXCH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01905">
        <property type="entry name" value="paired_CXXCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Paired_CXXCH_1" evidence="1">
        <location>
            <begin position="226"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="1">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="330" mass="35816" checksum="733397C4677362B6" modified="2005-11-22" version="1">MSRRGITGVVTAVFLGWAAVAFGGVSFIYPAPNAWVENSNHLILKLNSTEVTGVRIGVNGVVSDLLVVGSPEYRRAFQDFLIVQPVWDRGRNEVTVETFIGKSRAETAQASVYFAPGAKASDIPPEFKANSFHQPDLEARCVGCHDMAPSSDKSLSTLAKENPCIGCHRKMLDVKFVHGPAGTYSCGYCHKEKATPKYVVTKREAPLCNECHGDKAAEFAKRKYIHGPIAGGMCEVCHDSHGSANYGQLKAPINELCLSCHESIKKTPHVVRTTTGAGHPVSGAKDPSAPKTGREMSCISCHNPHAGDARYFFVNNSEDRLLLCQMCHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RL8</accession>
    <name>Q39RL8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Undecaprenyl-diphospho-oligosaccharide flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2888"/>
    <dbReference type="EnsemblBacteria" id="ABB33106">
        <property type="protein sequence ID" value="ABB33106"/>
        <property type="gene ID" value="Gmet_2888"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2888"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026911_6_1_7"/>
    <dbReference type="OMA" id="DLAFYWD"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="340"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="494" mass="54965" checksum="CE11946152529B66" modified="2005-11-22" version="1">MTDRTTDNQQQEFQELKKKSLSGMTALFIRQVLVKLIFFGGNIVLARLLAPQVFGIYAIVNFVVTFFSTFGDVGIGAALIQKKGELSREELSTTFWLQQMLVWSVVAVAVLAAPLALRVYPTLPPVGVWLIRAMALSFFFSSLKTIPAILMEREIDFNRIAWVDITENLAFQGVAITGAFLGWEAWSFVAAAVTRGFLGALLIYSLSSWRPSLHYRFESVKGLVRFGLPYQGNQILSFIKDAVTPLFVGAYAGAAAVGYLNWARNFAFVPLVISETFGRVAFPAFSQLQDDRELLGHTIENSIRMMTFVMLPVTGIFIALGPEITHYFYTDKWFPAINAFYLFSWAPLMMGVTLPMFSGILSIGKSKIILAMSLALIGIEWGIGAPLVTRIGFTGVAVTQPISYIIFTVVYKHVLRRQRVRVNVVRNAYLNLLIAALMAAIVWYAKGGLVTSLPALVAFAGMGLVVYLLLSFMLNRGTLKESLRYFRKLREPTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RM4</accession>
    <name>Q39RM4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2882</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514613.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2882"/>
    <dbReference type="EnsemblBacteria" id="ABB33100">
        <property type="protein sequence ID" value="ABB33100"/>
        <property type="gene ID" value="Gmet_2882"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2882"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099338_0_0_7"/>
    <dbReference type="OrthoDB" id="1987706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="223" mass="25679" checksum="39192A71E59493CE" modified="2005-11-22" version="1">MWRDWLSLQGLRVAIKDPKYKVLHGRFAKSGFDLLDVGCGNHSAGLTKRLFPKVRYSGVDRDVYNNSDEDFKSMERYYRIDLMDGDLREIPDRGFDAVWVNHVIEHIPNGIEIVVALTGKLREKGLIYIEFPSVRSLSLPSWEGTLNFCDDESHVRVYDVKEISNALLMSGCRIVRAGQRQDKILIVCNFVRWIFLKIAGRKVPASMLWDFFGFADYVLAVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RN0</accession>
    <name>Q39RN0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514607.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2876"/>
    <dbReference type="EnsemblBacteria" id="ABB33094">
        <property type="protein sequence ID" value="ABB33094"/>
        <property type="gene ID" value="Gmet_2876"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2876"/>
    <dbReference type="eggNOG" id="COG4123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061983_3_1_7"/>
    <dbReference type="OMA" id="GLLCARD"/>
    <dbReference type="OrthoDB" id="1027015at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044260">
        <property type="term" value="P:cellular macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043412">
        <property type="term" value="P:macromolecule modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044238">
        <property type="term" value="P:primary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTS" evidence="1">
        <location>
            <begin position="32"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="255" mass="27823" checksum="DE459A5B7FBF14B2" modified="2005-11-22" version="1">MKADETIDELQTYDLRIAQERHGYRFSLDPLLLCAFAAPQVGARVIDLGTGSAVIPLVLARRTVQATFVGVELQEGLATLAERNVALNGLVDRISILCDDVLGLRKRFPVSSFDVVVSNPPYRKRGTGKVSPKVGRDDARHESSATLADFLAAAKYLVNPTGRICFIYHPSRLPELFSEAHVQKLASMRLRLVHGTSDAEARMALIEFCKGRRADLKVLPPLIVRGDGLGYTPEVAEILGGDRQGDCRQSVKASG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RN8</accession>
    <name>TRMD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine-N(1)-)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmD</name>
        <name type="ordered locus">Gmet_2868</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates guanosine-37 in various tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = H(+) + N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase TrmD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514599.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RN8"/>
    <dbReference type="SMR" id="Q39RN8"/>
    <dbReference type="STRING" id="269799.Gmet_2868"/>
    <dbReference type="EnsemblBacteria" id="ABB33086">
        <property type="protein sequence ID" value="ABB33086"/>
        <property type="gene ID" value="Gmet_2868"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2868"/>
    <dbReference type="eggNOG" id="COG0336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047363_0_1_7"/>
    <dbReference type="OMA" id="ILCGHYK"/>
    <dbReference type="OrthoDB" id="525632at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N(1))-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18080">
        <property type="entry name" value="TrmD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1270.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00605">
        <property type="entry name" value="TrmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002649">
        <property type="entry name" value="tRNA_m1G_MeTrfase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023148">
        <property type="entry name" value="tRNA_m1G_MeTrfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016009">
        <property type="entry name" value="tRNA_MeTrfase_TRMD/TRM10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46417">
        <property type="entry name" value="PTHR46417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01746">
        <property type="entry name" value="tRNA_m1G_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000386">
        <property type="entry name" value="tRNA_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00088">
        <property type="entry name" value="trmD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000257423" description="tRNA (guanine-N(1)-)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="132"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00605"/>
        </source>
    </evidence>
    <sequence length="245" mass="27353" checksum="496680835AC7E929" modified="2005-11-22" version="1">MKFDILTLFPAMFEGPLTESIIRRAVEKGLLDIRLHQIRDFATDRHKVVDDAPYGGGDGMVMKVEPIAACLEAVKAERPKARVLLTSPRGRLFDNAAARELAQEQEVIIICGRYEGIDERVRELFVEDEFSIGDFVLTGGELAAMVMIDATVRFVPGVLGSPGSAETDTFSDGLLEYPHYTRPAEFRGHSVPAVLLSGNHAEVARWRRRKALEETIRSRPDLLEKAVLDSDDRRYLLELEEGASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RP8</accession>
    <name>Q39RP8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Adenosine 5'-phosphosulfate reductase</fullName>
            <shortName evidence="10">APS reductase</shortName>
            <ecNumber evidence="6 10">1.8.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">5'-adenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">Thioredoxin-dependent 5'-adenylylsulfate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">apr</name>
        <name evidence="10" type="synonym">cysH</name>
        <name evidence="12" type="ordered locus">Gmet_2858</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 10">
            <text>[thioredoxin]-disulfide + AMP + 2 H(+) + sulfite = [thioredoxin]-dithiol + adenosine 5'-phosphosulfate</text>
            <dbReference type="Rhea" id="RHEA:21976"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.8.4.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 10">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.10" evidence="6 10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514558.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2858"/>
    <dbReference type="EnsemblBacteria" id="ABB33076">
        <property type="protein sequence ID" value="ABB33076"/>
        <property type="gene ID" value="Gmet_2858"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2858"/>
    <dbReference type="eggNOG" id="COG0175">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044089_1_0_7"/>
    <dbReference type="OMA" id="PIARWTQ"/>
    <dbReference type="OrthoDB" id="674332at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011798">
        <property type="entry name" value="APS_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000857">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02055">
        <property type="entry name" value="APS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAPS_reduct" evidence="11">
        <location>
            <begin position="35"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; cysteine thiosulfonate intermediate" evidence="10">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="235" mass="26709" checksum="ADDBE5E823F957D6" modified="2005-11-22" version="1">MTATIQKTIPQLPQDATPQDILRAGVSATEGSVKLACSFSVEDVIIIDMAKELGCPIGIFALDTGRLHEETYEVADAITERYRIPIDWYFPRHETVEKLERDKGLFSFRESLDNRHECCHIRKVEPLGRALKGLAGWITGLRREQSVTRTGLAPIESDEANGGILKINPLLEWSEEQVWEYAEKRRVPVNRLHKQGYPSIGCAPCTRPVAPGEHPRAGRWWWENPEHKECGLHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RQ2</accession>
    <name>Q39RQ2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase sigma factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rpoH</name>
        <name evidence="9" type="ordered locus">Gmet_2854</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the sigma-70 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514562.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2854"/>
    <dbReference type="EnsemblBacteria" id="ABB33072">
        <property type="protein sequence ID" value="ABB33072"/>
        <property type="gene ID" value="Gmet_2854"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2854"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_5_7"/>
    <dbReference type="OMA" id="MNERPMT"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012759">
        <property type="entry name" value="RNA_pol_sigma_RpoH_proteobac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02392">
        <property type="entry name" value="rpoH_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <keyword evidence="5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="7">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="RNA_pol_sigma70" evidence="8">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="279" mass="32064" checksum="C87B526BF1404DAC" modified="2005-11-22" version="1">MTMNLPVVADSFTLYLAEIRKFPVLTPEEEHLYAVKFYEEKDLEAAHRLITANLRFVVKVAAEYKSYGMKMLDLIQEGNIGLMMAVRKFDPHKGIRLISYAVWWIRAYIQNYIISAWSLLKIGTTQAQKKLFFKLNQAKNAIRRLTGGDDTEATALSLHVKESEVIEMDQRMRGDYSLDAELVDGEGLTMLDTLVDERQNQEEALAEQQEASRLHGQVTQALERLNEKERYVVENRVTADEPLTLQEIADHFAISRERVRQIEEGALKKIKAYLTPITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="125" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RU5</accession>
    <name>Q39RU5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Gmet_2811</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366105.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2811"/>
    <dbReference type="EnsemblBacteria" id="ABB33029">
        <property type="protein sequence ID" value="ABB33029"/>
        <property type="gene ID" value="Gmet_2811"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2811"/>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_7"/>
    <dbReference type="OMA" id="GNCTFAN"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="306"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="14">
        <location>
            <begin position="439"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="522"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="484"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB33029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="738" mass="82113" checksum="79AF4008112565BB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RV7</accession>
    <name>Q39RV7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2799"/>
    <dbReference type="EnsemblBacteria" id="ABB33017">
        <property type="protein sequence ID" value="ABB33017"/>
        <property type="gene ID" value="Gmet_2799"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2799"/>
    <dbReference type="eggNOG" id="ENOG50338YP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1097367_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="253" mass="28823" checksum="971CE644FF83F2CE" modified="2005-11-22" version="1">MRLVTLGEKEKGMGSSEKVTARIATRVEELVADFDSYVTVFTQSGRFTGPCWYFHEKTIQARNDAPSIEALFADHTFFEYLYATLTSWGLHRMGPGNAKLRDIEEIKESFNLQLQAISDLSKLSLLTLPRENIRKTAEKVWRVLTSLRVSIAEAQIVANSKALHHVIPCLLPPIDREYTFNFFYDRKSLSIPEERAFIEMFTAMAEIARRNAEAIHRFQGSPWNTSESKVIDNAVVGFMIHKATPNTPLEPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S01</accession>
    <name>Q39S01_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366095.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2755"/>
    <dbReference type="EnsemblBacteria" id="ABB32973">
        <property type="protein sequence ID" value="ABB32973"/>
        <property type="gene ID" value="Gmet_2755"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2755"/>
    <dbReference type="HOGENOM" id="CLU_2011964_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="123" mass="14951" checksum="7ED6895D7FE0A78D" modified="2005-11-22" version="1">MLEIVILGIIIWAVWYYMKETRLERQKQKFEKFSQECASREEDRRDGKVTEIQRANMNELASYVKPLLYKFQRDIPPRFFDDLENLVQSYVDEVKAQKLYSLYNVLLNSNVKNVYENLNKFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S88</accession>
    <name>Q39S88_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511793.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2668"/>
    <dbReference type="EnsemblBacteria" id="ABB32886">
        <property type="protein sequence ID" value="ABB32886"/>
        <property type="gene ID" value="Gmet_2668"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2668"/>
    <dbReference type="HOGENOM" id="CLU_2734274_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="71" mass="8184" checksum="7E1FDBC18195FD9D" modified="2005-11-22" version="1">MVVETKGYHLKNDDTDYKEKLLDLCTEMFRWENVKTVGELELEYDAKTSVACALVFQEHWRTELAALSGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SB1</accession>
    <name>Q39SB1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2645</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511817.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2645"/>
    <dbReference type="EnsemblBacteria" id="ABB32863">
        <property type="protein sequence ID" value="ABB32863"/>
        <property type="gene ID" value="Gmet_2645"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2645"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_1_7"/>
    <dbReference type="OMA" id="NQQGYAG"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16925">
        <property type="entry name" value="TetR_C_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="6"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="194" mass="21092" checksum="AD0172B0E8122155" modified="2005-11-22" version="1">MKSKGEETRSRILDTATDLIHRKGFGATSINDLLEATNIKKGCLYFHFPGKDALGLAVLEKMRDDFLDVLETSLAGTTPGECLDNFFATVADVHKGRGFVGGCIFGNTALEMGDTDNRLVAIIRQVFKTWLGKLKTVIAAAQNSGEVRNDIPADILACQMLAAIEGGIMLSRLEKDEKPLCDALGALRTMMRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ST4</accession>
    <name>Q39ST4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512435.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2465"/>
    <dbReference type="EnsemblBacteria" id="ABB32690">
        <property type="protein sequence ID" value="ABB32690"/>
        <property type="gene ID" value="Gmet_2465"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2465"/>
    <dbReference type="eggNOG" id="COG2223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_59_7_7"/>
    <dbReference type="OMA" id="WVLASHQ"/>
    <dbReference type="OrthoDB" id="1594866at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="454" mass="46679" checksum="1315D9FB7D1465E4" modified="2005-11-22" version="1">MSDTVKNRGWQVTLAGTGINLALGVLYAWSIFKGAIKSSIEKGGPGAFNWDKASINDPYAICCLAFAFSMIIAGKAQDKIGPARTALIGGVLVGTGFAILSQSNSYLAWVIGFGILAGSGFGFGYSAATPPALKWFPSSKTGLIAGIVVAGFGLAPVYIAPLATWLLGSVGIQTSMLILAAAFAIVVCGLSFFLVNPPAGYVPADAPKSDAAAKAAPAKPTVNATAGEMLKSGKFYILWITYFIGAGAGLMVIGSVAGIAKKSMGSMAFLAVAIMALGNAGGRVVAGILSDKIGRMATLCIMFVFQAALMFAAIPLVGAGHPNAVLIVLLATFIGFNYGANLSLFPSFSKDYWGLKNYGLNYGLLFTAWGVGGFVMGRVSEMLNTSTGSFTTSFTLAGSLLIGGAVMSLALRPAKAAKPAEVAIAEPSARGVFMESFMRGCADFLGFTPSPRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SV7</accession>
    <name>Q39SV7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron/manganese-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ideR</name>
        <name evidence="4" type="ordered locus">Gmet_2442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FeoA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512458.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2442"/>
    <dbReference type="EnsemblBacteria" id="ABB32667">
        <property type="protein sequence ID" value="ABB32667"/>
        <property type="gene ID" value="Gmet_2442"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2442"/>
    <dbReference type="eggNOG" id="COG1321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1918">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069532_0_1_7"/>
    <dbReference type="OMA" id="KACQFEH"/>
    <dbReference type="OrthoDB" id="2047422at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007167">
        <property type="entry name" value="Fe-transptr_FeoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001367">
        <property type="entry name" value="Fe_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036421">
        <property type="entry name" value="Fe_dep_repressor_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038157">
        <property type="entry name" value="FeoA_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022689">
        <property type="entry name" value="Iron_dep_repressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02742">
        <property type="entry name" value="Fe_dep_repr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04023">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00899">
        <property type="entry name" value="FeoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00529">
        <property type="entry name" value="HTH_DTXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47979">
        <property type="entry name" value="SSF47979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FeoA" evidence="3">
        <location>
            <begin position="144"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="214" mass="23858" checksum="A23D903901CCD647" modified="2005-11-22" version="1">MKLSEKAEEILEALWIACEEEGKPSLDKEEITVAAGDPAYGELASLAFIEMRDGRVSLRPEGKDEGKRTVRRHRLAERLMMDVFNIRGDSAEAKACEFEHLLHEEVDAKVCTMLNHPVTCPHGKPIPPGDCCDTARKSGDLGVVPLTELKAGEEGDIAYILTEDDTKMRKLMAMGVLPGNRINLMQTFPSYIFRIGYSEFAIDTALAREIHVRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SY6</accession>
    <name>Q39SY6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutaredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2413</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512487.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2413"/>
    <dbReference type="EnsemblBacteria" id="ABB32638">
        <property type="protein sequence ID" value="ABB32638"/>
        <property type="gene ID" value="Gmet_2413"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2413"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164657_0_0_7"/>
    <dbReference type="OMA" id="LYSVSWC"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011911">
        <property type="entry name" value="GlrX_YruB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02196">
        <property type="entry name" value="GlrX_YruB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223099" evidence="1">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaredoxin" evidence="2">
        <location>
            <begin position="46"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="126" mass="13882" checksum="57BEEF31053AA923" modified="2005-11-22" version="1">MKKISALIPLLMLSLAAVSGQAAEAPAAGQSKIDAVATKQQAYPKVVLYSVAWCPHCKEAKEYFTRNNIPFINKDVELDEKAMDELTKTYKSQGVPVIVIGDDKKVLKGFNPELFEKAVKDIQSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T24</accession>
    <name>Q39T24_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="5">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">aroF</name>
        <name evidence="7" type="ordered locus">Gmet_2375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 5">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513245.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2375"/>
    <dbReference type="EnsemblBacteria" id="ABB32600">
        <property type="protein sequence ID" value="ABB32600"/>
        <property type="gene ID" value="Gmet_2375"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2375"/>
    <dbReference type="eggNOG" id="COG0722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030903_0_1_7"/>
    <dbReference type="OMA" id="VMENVAN"/>
    <dbReference type="OrthoDB" id="853329at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00084"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DHAP_synth_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PTHR21225"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP_synth_1" evidence="6">
        <location>
            <begin position="43"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="355" mass="39135" checksum="B3BC35986546FC18" modified="2005-11-22" version="1">MTKTSNLKVTSITPIIAPADLRQVFPQSLETAEFVNASRAHIKNILKGKDTRLMVVVGPCSIHDPKAALDYAGRLARLASELSDQLFIVMRVYFEKPRTTIGWKGLINDPDMNHTHQISKGLGIARRLLNDITSMLLPVACEMLDTITPEYLADYISWGAIGARTTESQSHREMASGLSFPVGFKNGTDGNLQIAIDAMNAALHPHSFLGINRDGKTSIIQTTGNPDVHIVLRGGKKPNYSPEDIAKTEEMVEKGGIFPTIMVDCSHGNSEKRHEKQPEVLDSIVDQIEAGNRSISGVMIESFLEAGNQPIPKDLSQLRYGVSTTDKCIDWKTTEEILRKAHERLKRCGGRPMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T68</accession>
    <name>Q39T68_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose--lipopolysaccharide heptosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32556.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513289.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2331"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32556">
        <property type="protein sequence ID" value="ABB32556"/>
        <property type="gene ID" value="Gmet_2331"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2331"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_6_0_7"/>
    <dbReference type="OMA" id="DKKWPAD"/>
    <dbReference type="OrthoDB" id="1326265at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008920">
        <property type="term" value="F:lipopolysaccharide heptosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009244">
        <property type="term" value="P:lipopolysaccharide core region biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011908">
        <property type="entry name" value="LipoPS_heptosylTferase-I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02193">
        <property type="entry name" value="heptsyl_trn_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32556.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="355" mass="39174" checksum="60EE6F239755053F" modified="2012-10-31" version="2">MPLRVLIVKVSALGDVIHALPVLDYLHQVSSGIEIDWVVEEGNRDILEGHPLLRRLHVVRTKAWRRDPLSDTTRREISAIRRELREADYDIAFDLQGNVKSGIITWLSGARRRYGFDREGVRESLNLLFTTNQVPLRRQDHHISHRSLRVVSVPLGRDYTGMTIGPDIFTSPEDDAAAEALLATLDDGLAFLFHNGTTWTTKLWYEEGWIGLGRKVLGRYPDSTILLSWGNEQEKNAAETIAAGIGRGVRVLPKLSLKGFCALLKKVDLVVGGDTGPIHMAAAVGTPTVSFYRSTDGRRNGPLGDQHVVIQSPLDCTACLRKSCDKDAPCRASITADVLMSGIEKLLTPPFPSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TJ4</accession>
    <name>Q39TJ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365959.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2203"/>
    <dbReference type="EnsemblBacteria" id="ABB32430">
        <property type="protein sequence ID" value="ABB32430"/>
        <property type="gene ID" value="Gmet_2203"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2203"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_7"/>
    <dbReference type="OMA" id="CFGHPMG"/>
    <dbReference type="OrthoDB" id="862072at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044248">
        <property type="term" value="P:cellular catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="192"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="290" mass="31188" checksum="30CF49C653521AFB" modified="2005-11-22" version="1">MGDIKKVAILGAGMMGSDIALSCALAGYDVLLKEVSLDLAAAGVERIRGSLAKWSEKGRLAVDAEQQKSAVARITPVDNFSGFGDVDLVIEAIFEDLDVKSQNFRQLEEVCKPSCIIASNTSSLPITKLGACFSSAERKSRFVGMHFFSPAAIMKLVEVVNGEDTSAETVETACAFCTSIGKEPIKVNDCAGFVVNRILGAINDEAIRLLEENVASAADIDKACQLGLGHPVGPFALMDQISNELNLKIARIFHGIYGDRFLPRPALVRKVDAGHFGRKTGKGWFDYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TK3</accession>
    <name>Q39TK3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365950.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2194"/>
    <dbReference type="EnsemblBacteria" id="ABB32421">
        <property type="protein sequence ID" value="ABB32421"/>
        <property type="gene ID" value="Gmet_2194"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2194"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="RIWDSKV"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="255" mass="27275" checksum="5C309D6264855285" modified="2005-11-22" version="1">MGLERFSLKGKTAIVTGASQGLGEAMALGLAEAGANLVLASRNEASMAKVASEVTSKGVQCLTVKTDMLKADDIQAMVDKGIAQFGTIDILVNNAGINLVKPFVNLTEEDWDSVVDTNLKGYFLCSQVVGREMIKNKNGCVINNASVFGLRGFPNIASYIASKGGVVQLTRGLAVEWARHNIRVNCIAPGYIVTEMAKRDIETNPKILEQNLLKIPMKRGGQPREVADVVVFLASEASSYMTGQIVSMDGGWSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TT2</accession>
    <name>Q39TT2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative_PNPOx domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513092.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2113"/>
    <dbReference type="DNASU" id="3739449"/>
    <dbReference type="EnsemblBacteria" id="ABB32342">
        <property type="protein sequence ID" value="ABB32342"/>
        <property type="gene ID" value="Gmet_2113"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2113"/>
    <dbReference type="eggNOG" id="COG3787">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105087_2_0_7"/>
    <dbReference type="OMA" id="GFGHTDL"/>
    <dbReference type="OrthoDB" id="1804797at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="11"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="158" mass="17383" checksum="C0C135CA0143856A" modified="2005-11-22" version="1">MKDALGMRVQRYLLDHNVATVATSGSGGPWAAAVFYANDGYTLYFLSSPTTRHCLDLAQEACVAVTIQEDYADWLEIKGVQIEGIAVEISGAEEEKARKLYGRKFPVVGLLAQAPAAIVKAMAKVRWYKVVPHRLYFIDNSLGLGNRDEVDLSMADKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TY7</accession>
    <name>Q39TY7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514045.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39TY7"/>
    <dbReference type="STRING" id="269799.Gmet_2058"/>
    <dbReference type="EnsemblBacteria" id="ABB32287">
        <property type="protein sequence ID" value="ABB32287"/>
        <property type="gene ID" value="Gmet_2058"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2058"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_7"/>
    <dbReference type="OMA" id="WGCANQA"/>
    <dbReference type="OrthoDB" id="550338at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="6">
        <location>
            <begin position="276"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="399" mass="42504" checksum="7211C915D8AAF54C" modified="2005-11-22" version="1">MREAVIVDAVRTPVGKFNGALKNVRSDDLAAHCISELVKRNNLDPNLVEDVVLGCTNQAGEDNRNVGRMAALLAGLPYSVAGQTINRLCASGLNAINSAAHAIKLGEGDVFIAGGTESMTRAPFVMAKSESPFSRDIRVFDSVIGWRFTNPKMTEPYAKEGMGETAENVAVRYGLTRQEQDEFALETQRKWAAADAAGKFNDEIVPVVIPQKKGDPIIVSRDEFPRGNDVTMEQLAKLPAAFRKEGTVTAGNSSGINDGAAALLLMEAETAKKLGYKPLARVVASAVAGCDPSYMGLGPIPAIQKVLQRSGLKIEDIDLFELNEAFAAQSIPCIRELGIDPAKVNVNGGSIAIGHPLGSTGARITATLVHEMKRRGSRYGLVSLCIGVGQGIATIFERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U73</accession>
    <name>Q39U73_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1972</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511872.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1972"/>
    <dbReference type="EnsemblBacteria" id="ABB32201">
        <property type="protein sequence ID" value="ABB32201"/>
        <property type="gene ID" value="Gmet_1972"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1972"/>
    <dbReference type="eggNOG" id="COG2084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_1_0_7"/>
    <dbReference type="OMA" id="METPYPK"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="2">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="3">
        <location>
            <begin position="166"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="288" mass="31243" checksum="BDE33B7D79F3B51E" modified="2005-11-22" version="1">MLKNVGFLGLGTVGRHMAINLLKGSYTLTVYDSDPEVVAELVKQGALGAGTPREAAKGQDIVIYIRPEKERLKPDIYGEDGIFAGIDPGTILVDMGTHSLESTKEMAEEAAKHRVMFLDAPVWGTKEHAANGLLTILAGGDPSLLGRCRELFSFFGLNIIHVGSIGDATRMKFVVNLVQAELMETLAEAIVFGEKMGFNVDKILEVLDSGGVASPLFHSKGRVIARGDFTRNLALKYVHEQLELVLEKSQKLGLDLPAAMVACKTYEQGVKDGRGEEDFSSVVKVLRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U98</accession>
    <name>PGK_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="1">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pgk</name>
        <name type="ordered locus">Gmet_1947</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511896.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39U98"/>
    <dbReference type="SMR" id="Q39U98"/>
    <dbReference type="STRING" id="269799.Gmet_1947"/>
    <dbReference type="EnsemblBacteria" id="ABB32176">
        <property type="protein sequence ID" value="ABB32176"/>
        <property type="gene ID" value="Gmet_1947"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1947"/>
    <dbReference type="eggNOG" id="COG0126">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025427_0_2_7"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="462069at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PTHR11406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="SSF53748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000009614" description="Phosphoglycerate kinase">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="61"/>
            <end position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00145"/>
        </source>
    </evidence>
    <sequence length="398" mass="43578" checksum="E0BC3F3D7D3C0420" modified="2005-11-22" version="1">MAIRYIDEIESLKGKKVFIRVDFNVPLDEHQNITEDTRIRAVLPTINFALDAGAKVILASHLGRPKGERKPKYSMAPAAKRLSRLLNKEVQLAPDCIGDEVKKMIDAMKPGEVLLLENVRFYEGEEKNDADFAKALANDCEIYINDAFAVSHRAHASVEAITKFFPVVAAGFLMNNEINYFEKAMQKPIRPLVAILGGAKVSGKLEVLESLVNKVDKIIIGGGMAFTFLKALGYNVGKSLVEEELLEIALTTYTKAREKGVKFYLPVDCVAADRFNPEAETKVTTIQEIPEEWMALDIGPATVTLFTEALQNAKTIIWNGPMGVFEMDAFSRGTFAMVSAVANSYALTIVGGGDTDSAVHRAGEYAKISYISTGGGAFLELLEGKHLPGIKVLEENGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UD5</accession>
    <name>Q39UD5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="11">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Gmet_1910</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="11"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32139.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1910"/>
    <dbReference type="EnsemblBacteria" id="ABB32139">
        <property type="protein sequence ID" value="ABB32139"/>
        <property type="gene ID" value="Gmet_1910"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1910"/>
    <dbReference type="eggNOG" id="COG0209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079049_0_0_7"/>
    <dbReference type="OMA" id="MMATMRC"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10 11" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 11" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_lgN" evidence="12">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="13">
        <location>
            <begin position="84"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32139.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="565" mass="62046" checksum="EFA67A34B323484A" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UF5</accession>
    <name>Q39UF5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent zinc metalloprotease FtsH</fullName>
            <ecNumber evidence="5">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ftsH</name>
        <name evidence="8" type="synonym">ftsH-2</name>
        <name evidence="8" type="ordered locus">Gmet_1890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the central section; belongs to the AAA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511954.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1890"/>
    <dbReference type="MEROPS" id="M41.001"/>
    <dbReference type="EnsemblBacteria" id="ABB32119">
        <property type="protein sequence ID" value="ABB32119"/>
        <property type="gene ID" value="Gmet_1890"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1890"/>
    <dbReference type="eggNOG" id="COG0465">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000688_16_2_7"/>
    <dbReference type="OMA" id="QYGMTER"/>
    <dbReference type="OrthoDB" id="190468at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011546">
        <property type="entry name" value="Pept_M41_FtsH_extracell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06480">
        <property type="entry name" value="FtsH_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="SSF140990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="AAA" evidence="7">
        <location>
            <begin position="185"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="416"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="193"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="419"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="608" mass="66779" checksum="ECF907C8256E3A17" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UG4</accession>
    <name>Q39UG4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yjeE</name>
        <name evidence="5" type="ordered locus">Gmet_1881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TsaE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511963.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1881"/>
    <dbReference type="EnsemblBacteria" id="ABB32110">
        <property type="protein sequence ID" value="ABB32110"/>
        <property type="gene ID" value="Gmet_1881"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1881"/>
    <dbReference type="eggNOG" id="COG0802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087829_3_0_7"/>
    <dbReference type="OMA" id="FTDDAIC"/>
    <dbReference type="OrthoDB" id="1827295at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003442">
        <property type="entry name" value="T6A_TsaE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02367">
        <property type="entry name" value="TsaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00150">
        <property type="entry name" value="T6A_YjeE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="17886" checksum="3E1ED1286F91716A" modified="2005-11-22" version="1">MVSVTSHSVEETIRLGERLGRLLEPGSFIALTGELGAGKTQFVRGVASGLGIDSSVPITSPTFTLLNEYQGRIRLYHFDLYRLGGVDDAAELGFDEYFDGNGVCLVEWAERLGSDILTERLDIIFDYLSDTERRIDFISHGSNHEALLKKCFDRRLDSCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UG8</accession>
    <name>Q39UG8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DHH domain phosphoesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1877</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511968.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1877"/>
    <dbReference type="EnsemblBacteria" id="ABB32106">
        <property type="protein sequence ID" value="ABB32106"/>
        <property type="gene ID" value="Gmet_1877"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1877"/>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046377_1_0_7"/>
    <dbReference type="OMA" id="KCATALM"/>
    <dbReference type="OrthoDB" id="1040743at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="1">
        <location>
            <begin position="26"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="360" mass="40443" checksum="4617AAE3A1863E8D" modified="2005-11-22" version="1">MGLGSENLDTKRFTDEMLDWVRGRGKILIVIHDNPDPDCLASAIALRHLFVMKVNREATIAFSGMISRSENLAMAKELEIPLTPIGLINFREFSVVCMLDTQPGTGNNSLPADSSVDILVDHHPMRETSEKCRWVDIREDYGVTATILYEYLVTQGVYLGTKLATALFYAIKSETQDLGREANKPDRDAYLKLFTLSNKKLLYEITHPKLPVEYYLMVNRALENTKIYGKLLITNLAQMNFPEMVAEMADFFLRLEGIELVLAMGQYGDGMLLSLRTIRHDLNAGILIGVLVEGRGHAGGHGMMAGGKIENVPASPEAIHEAEDFLANRLLAELHIVDTKPQRLQELREKRNFNDPLREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UK7</accession>
    <name>Q39UK7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Elongation factor P</fullName>
            <shortName evidence="7">EF-P</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">efp-2</name>
        <name evidence="7" type="synonym">efp</name>
        <name evidence="11" type="ordered locus">Gmet_1838</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7 8">Belongs to the elongation factor P family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512008.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1838"/>
    <dbReference type="EnsemblBacteria" id="ABB32067">
        <property type="protein sequence ID" value="ABB32067"/>
        <property type="gene ID" value="Gmet_1838"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1838"/>
    <dbReference type="eggNOG" id="COG0231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074944_0_0_7"/>
    <dbReference type="OMA" id="WSVVEFQ"/>
    <dbReference type="OrthoDB" id="1260763at2"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04470">
        <property type="entry name" value="S1_EF-P_repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05794">
        <property type="entry name" value="S1_EF-P_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00141">
        <property type="entry name" value="EF_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015365">
        <property type="entry name" value="Elong-fact-P_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020599">
        <property type="entry name" value="Transl_elong_fac_P/YeiP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013185">
        <property type="entry name" value="Transl_elong_KOW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001059">
        <property type="entry name" value="Transl_elong_P/YeiP_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013852">
        <property type="entry name" value="Transl_elong_P/YeiP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011768">
        <property type="entry name" value="Transl_elongation_fac_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30053">
        <property type="entry name" value="PTHR30053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01132">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08207">
        <property type="entry name" value="EFP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09285">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005901">
        <property type="entry name" value="EF-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01185">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00841">
        <property type="entry name" value="Elong-fact-P_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00038">
        <property type="entry name" value="efp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01275">
        <property type="entry name" value="EFP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EFP" evidence="10">
        <location>
            <begin position="67"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Elong-fact-P_C" evidence="9">
        <location>
            <begin position="129"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="187" mass="21197" checksum="082BB77635FFD002" modified="2005-11-22" version="1">MYTVADLKKGLKITLDGDPYLVTAFEFSKPGKGQALYRTKMRNMITGTTLDRTYRSGETFEPARLEERQMQYLYKEDNHYTFMDNQTFEQVQMSEDAVGDAKNFMIDNIQVDVLMFGEKAIGVSLPNFVNLRVVQTDPWVKGDTSGSDSKPATVETGYVLRVPPFIEEGEMIVVDTRTGDYSTRVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UQ3</accession>
    <name>Q39UQ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase, MutT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1790"/>
    <dbReference type="DNASU" id="3741467"/>
    <dbReference type="EnsemblBacteria" id="ABB32021">
        <property type="protein sequence ID" value="ABB32021"/>
        <property type="gene ID" value="Gmet_1790"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1790"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_19_1_7"/>
    <dbReference type="OMA" id="HADQPGM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="154" mass="17277" checksum="B6DF6717F8D2CFA6" modified="2005-11-22" version="1">MGQFSISEVGHFYIAANTSLKHIHVTCAIIERDGLVLAAQRSAVMSLPLKWEFPGGKIDPGESPEECLRRELVEEMAVHVRVGQSLPVSTHQYPTFSVTLYPFLCTIESGEIVLHEHVAVTWLPPDELHTLDWAEADLPVIKSYQQGCRMRDHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UZ5</accession>
    <name>Q39UZ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane lipoprotein carrier/sorting protein LolA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514156.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1698"/>
    <dbReference type="EnsemblBacteria" id="ABB31929">
        <property type="protein sequence ID" value="ABB31929"/>
        <property type="gene ID" value="Gmet_1698"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1698"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1353029_0_0_7"/>
    <dbReference type="OMA" id="FALMENP"/>
    <dbReference type="OrthoDB" id="1638668at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35869">
        <property type="entry name" value="PTHR35869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223420" evidence="2">
        <location>
            <begin position="25"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="206" mass="23035" checksum="9299B8E37A11968D" modified="2005-11-22" version="1">MRKVISTVMTLTLLLVLAWGGSAAARQIAPVEGLETLRRSFAGITDFSADIVQEKQISLLKRKMVSTGTVRFRKPSLFFMELNPPRASRLLLNDTQITLYFPREKSTSQMALPPEQSLQHWFTFLARPVTSLPDGVDVRADQQGDALTITVIPRSGGQVREFAVTLLTDGTIRKLVISEKNGDRTLITFSRVRKNSGLTDKDFRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V11</accession>
    <name>Q39V11_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bcr/CflA family efflux transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1682</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Bcr/CmlA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511382.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1682"/>
    <dbReference type="EnsemblBacteria" id="ABB31913">
        <property type="protein sequence ID" value="ABB31913"/>
        <property type="gene ID" value="Gmet_1682"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1682"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_47_0_7"/>
    <dbReference type="OMA" id="ITVIIME"/>
    <dbReference type="OrthoDB" id="1452500at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004812">
        <property type="entry name" value="Efflux_drug-R_Bcr/CmlA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00710">
        <property type="entry name" value="efflux_Bcr_CflA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="8">
        <location>
            <begin position="19"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="414" mass="43336" checksum="73FE29E005CA2ADB" modified="2005-11-22" version="1">MEMTAAPAIQPADMTRRQLARLVLILGALTAFSSMSIDMYLPAFPQIARDLAAPLGMVQLSISAFLFGSAAGQLFYGPMADRWGRRTPLLLGLTLYVAAAFGCAFVHTGEGLLFWRVVMAVGGGAGMVISRAVVRDLYDTAEAARMFSLLMLVMGAAPILAPIVGGQLLLITGWRGIFGFLAIFGLLSLAAAAMFLPESLPAERRSRRGVVEMGTIYAHLLRNNRYLRYAIALGCVAGVNFSYISGAPFVFIELHGVTPQHFGLFFGANACGLIGASQVNRRLLRRFSAQRILGTAATVNAVGALLLAVAGFTGIGGFPVQVALLFVCLCTSGFLYPNVTALAMAPFDKAAGSASALLGTIQYTLGATAGALVGMFHNGTAVPMTATMALCGVLGWCAIVGVARASSARRAPAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V87</accession>
    <name>GLYA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine hydroxymethyltransferase</fullName>
            <shortName evidence="1">SHMT</shortName>
            <shortName evidence="1">Serine methylase</shortName>
            <ecNumber evidence="1">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyA</name>
        <name type="ordered locus">Gmet_1605</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; glycine biosynthesis; glycine from L-serine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SHMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511460.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V87"/>
    <dbReference type="SMR" id="Q39V87"/>
    <dbReference type="STRING" id="269799.Gmet_1605"/>
    <dbReference type="EnsemblBacteria" id="ABB31837">
        <property type="protein sequence ID" value="ABB31837"/>
        <property type="gene ID" value="Gmet_1605"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1605"/>
    <dbReference type="eggNOG" id="COG0112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022477_2_1_7"/>
    <dbReference type="OMA" id="SHPAGLI"/>
    <dbReference type="OrthoDB" id="861782at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="UniPathway" id="UPA00288">
        <property type="reaction ID" value="UER01023"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="PTHR11680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000234979" description="Serine hydroxymethyltransferase">
        <location>
            <begin position="1"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="121"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="349"/>
            <end position="351"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <feature type="site" description="Plays an important role in substrate specificity" evidence="1">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00051"/>
        </source>
    </evidence>
    <sequence length="415" mass="44876" checksum="C4F7F265676A55C7" modified="2005-11-22" version="1">MSILETFDPAVAEAIRHETERQEYNLELIASENFVSEAVMEAQGSVLTNKYAEGYPGKRYYGGCHHVDVVENLAIERAKELFGADHANVQPHSGSQANMAVYFSVLKPGDTILGMNLSHGGHLTHGSPVNFSGRFFNVVPYGVSQETETIDFNEVERLALEHKPKLIVVGASAYPRVLDFAAFRAIADKVGALVMVDMAHIAGLVAAGLHPSPVPYAEFVTTTTHKTLRGPRGGMILCREEFAKTLNSNIFPGIQGGPLMHVIAAKAVAFKEALAPEFKLYQEQIVKNARTLADELMKRGFRLVSGGTDNHLMLVNLTGTELTGKVAEEALDKAGITVNKNTVPFETRSPFVTSGFRIGTPAATSHGLKEAEMVEVAAFIAEALANVGNEAKLAEVKGKVNALMGRFPLYASRLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VA9</accession>
    <name>RIMP_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimP</name>
        <name type="ordered locus">Gmet_1583</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for maturation of 30S ribosomal subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511482.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VA9"/>
    <dbReference type="SMR" id="Q39VA9"/>
    <dbReference type="STRING" id="269799.Gmet_1583"/>
    <dbReference type="EnsemblBacteria" id="ABB31815">
        <property type="protein sequence ID" value="ABB31815"/>
        <property type="gene ID" value="Gmet_1583"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1583"/>
    <dbReference type="eggNOG" id="COG0779">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070525_2_2_7"/>
    <dbReference type="OMA" id="YIHVSLY"/>
    <dbReference type="OrthoDB" id="1595498at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01734">
        <property type="entry name" value="YlxS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01077">
        <property type="entry name" value="RimP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003728">
        <property type="entry name" value="Ribosome_maturation_RimP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028998">
        <property type="entry name" value="RimP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036847">
        <property type="entry name" value="RimP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028989">
        <property type="entry name" value="RimP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035956">
        <property type="entry name" value="RimP_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33867">
        <property type="entry name" value="PTHR33867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02576">
        <property type="entry name" value="DUF150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17384">
        <property type="entry name" value="DUF150_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74942">
        <property type="entry name" value="SSF74942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75420">
        <property type="entry name" value="SSF75420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000229240" description="Ribosome maturation factor RimP">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01077"/>
        </source>
    </evidence>
    <sequence length="159" mass="18046" checksum="B2E753ED32417FF2" modified="2005-11-22" version="1">MAKDEVVDRVTALAESLLSSQEMELVDIEYKREGRHMVLRLFVDKAGGITLDDCALVSREFSEILDVEDFISENYTLEVSSPGLNRPLKRESDYERYRGRLVKVRTYDVVEDEAGNRRKTFLGDLEGLAGGVVTLKLREGQMARIPLAKIAKANLEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VD0</accession>
    <name>Q39VD0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclic diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511505.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1560"/>
    <dbReference type="EnsemblBacteria" id="ABB31794">
        <property type="protein sequence ID" value="ABB31794"/>
        <property type="gene ID" value="Gmet_1560"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1560"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_0_7"/>
    <dbReference type="OMA" id="YMEQANQ"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="2">
        <location>
            <begin position="122"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="317" mass="35048" checksum="96EF73F337B7D7CA" modified="2005-11-22" version="1">MKKSYLIHGAKGRVVILVLLTAVIALFHFVVPTESHVYHALHIVLRKLYFLPPVMAGAWFGLRGAVYTTSAVTILFSLHAFLDWPGNYMEQANQMGELASFWVVGLVSGWLFDRQRALLAELATANEETLLALVSALDMRAKNSRLHSLRVREIALRLADHLGVTENERKAIGFGALLHEVGKVSIHDSVFTLLKRVGLPELELKEMRSYPEAGYNLLRKIGFLREAAEIVRAHQEHFDGSGYPRGLRGEEIPLGARLLLIADTFEKLITGIGAVQCEEAVRIIREGSGGEFDPGLVDLFTGIGCDELSHVASAKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VD6</accession>
    <name>Q39VD6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FtrD-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31788.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1554"/>
    <dbReference type="EnsemblBacteria" id="ABB31788">
        <property type="protein sequence ID" value="ABB31788"/>
        <property type="gene ID" value="Gmet_1554"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1554"/>
    <dbReference type="eggNOG" id="COG4393">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120865_1_0_7"/>
    <dbReference type="OMA" id="HTAFDAC"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018758">
        <property type="entry name" value="FtrD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10080">
        <property type="entry name" value="FtrD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtrD-like" evidence="1">
        <location>
            <begin position="53"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31788.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="156" mass="16728" checksum="004467E3E78BD0FB" modified="2012-10-31" version="2">MKAAKKGFKWGILVAGALLAGVATVFALNFPGLSGVEKVKAVNGTVAIPLTKVSDGSAHFYRYTEGGKEIRFLVVKGSDGQFHTAFDSCDVCFREKKGYVQDGDTMLCKNCGKKFQINRIGPHSVGGCNPSYLPATSDGRNIIVKASDLQQGARYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VD8</accession>
    <name>Q39VD8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1552</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511515.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1552"/>
    <dbReference type="EnsemblBacteria" id="ABB31786">
        <property type="protein sequence ID" value="ABB31786"/>
        <property type="gene ID" value="Gmet_1552"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1552"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="LIRCMNL"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="4"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="221" mass="23982" checksum="7B571F96E34707A9" modified="2005-11-22" version="1">MALIEISNLTKHYSCGDETVEALRGVDIGIETGEFITIMGQSGSGKSTLLSILGGMNHPTSGKVTVNGTDLYALGEERLADFRAGNFGFVFQSFHLIPYLTAQENVMLPLTIASLKGDEKRQAALQALERVGLGGKADRLPNQLSGGEQERVAIARAIVNRPHILFADEPTGNLDTANSEAVMALFRELNDEGQTVVMVTHNPENCQYTDRTIHIRDGRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VF1</accession>
    <name>Q39VF1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">(R)-benzylsuccinate synthase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bssA</name>
        <name evidence="5" type="ordered locus">Gmet_1539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511527.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1539"/>
    <dbReference type="EnsemblBacteria" id="ABB31773">
        <property type="protein sequence ID" value="ABB31773"/>
        <property type="gene ID" value="Gmet_1539"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1539"/>
    <dbReference type="eggNOG" id="COG1882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009096_0_1_7"/>
    <dbReference type="OMA" id="KLSEWVW"/>
    <dbReference type="OrthoDB" id="116406at2"/>
    <dbReference type="BRENDA" id="4.1.99.11">
        <property type="organism ID" value="2414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001150">
        <property type="entry name" value="Gly_radical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004184">
        <property type="entry name" value="PFL_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01228">
        <property type="entry name" value="Gly_radical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02901">
        <property type="entry name" value="PFL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51149">
        <property type="entry name" value="GLY_RADICAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51554">
        <property type="entry name" value="PFL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0556">Organic radical</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PFL" evidence="4">
        <location>
            <begin position="42"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Glycine radical" evidence="3">
        <location>
            <begin position="732"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycine radical" evidence="2">
        <location>
            <position position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="862" mass="97613" checksum="FD3CF69F83E6AAB1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VI5</accession>
    <name>Q39VI5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-N-acetylglucosamine--undecaprenyl-phosphate N-acetylglucosaminephosphotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1505</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511562.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1505"/>
    <dbReference type="EnsemblBacteria" id="ABB31739">
        <property type="protein sequence ID" value="ABB31739"/>
        <property type="gene ID" value="Gmet_1505"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1505"/>
    <dbReference type="eggNOG" id="COG0472">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023982_7_0_7"/>
    <dbReference type="OMA" id="RFNTHPA"/>
    <dbReference type="OrthoDB" id="1151822at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008963">
        <property type="term" value="F:phospho-N-acetylmuramoyl-pentapeptide-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018480">
        <property type="entry name" value="PNAcMuramoyl-5peptid_Trfase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22926">
        <property type="entry name" value="PTHR22926"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01348">
        <property type="entry name" value="MRAY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="237"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="545" mass="58325" checksum="8397F9866731D901" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VK7</accession>
    <name>Q39VK7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidylserine decarboxylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1483</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511585.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1483"/>
    <dbReference type="DNASU" id="3740200"/>
    <dbReference type="EnsemblBacteria" id="ABB31717">
        <property type="protein sequence ID" value="ABB31717"/>
        <property type="gene ID" value="Gmet_1483"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1483"/>
    <dbReference type="eggNOG" id="COG0688">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_828355_0_0_7"/>
    <dbReference type="OMA" id="HYNHTPV"/>
    <dbReference type="OrthoDB" id="891720at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PTHR10067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="332" mass="37640" checksum="458B2D2DDC222C17" modified="2005-11-22" version="1">MIDQHQYIERESGSVCNERLFGDRLIRLLYHGARENAPFLFKMATSSWSSGLLGFINFDLPFGSNRRFLEECGVDLDECLDPPESLDTPRKVFERRIRYEQCRPMPEVQWAVVSPADARVLVGSFRDTSALFLKEKFFDFEELLGRHKEEWLRAFTGGEFAVFRLTPDKYHYNHTPVAGTVRDIYEIDGGYHSCNPGAVVIEATPFSKNRRVVTVIDTDVPGGTGVGLVAMIEVVALMIGQIVQCYSYEGYTAPRPVEPGMFLRRGVPKSLYRPGSSTDVLIFQRDRMHFADDIVRNMHDTRAASRFSHGFGRPLVETDVKVRSLIAVAVTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VM9</accession>
    <name>Q39VM9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic energy transduction protein, TonB-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511609.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1461"/>
    <dbReference type="EnsemblBacteria" id="ABB31695">
        <property type="protein sequence ID" value="ABB31695"/>
        <property type="gene ID" value="Gmet_1461"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1461"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090651_1_1_7"/>
    <dbReference type="OMA" id="WQWANDM"/>
    <dbReference type="OrthoDB" id="2037633at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="242" mass="25276" checksum="B97100E915D4EDEA" modified="2005-11-22" version="1">MATHKKKKPQLKNFFVPAAVVLVIIGGIGFVAKVMLTDTGAPRKNKITTVSLVKPPEQPKEKPPEPEPPKEMPKPQQIETPTMAQPDSPQQASQAPDDGPAAGSDLGVDGEGGAGSDGFGLVGKKGGRAITLGGGGGGGGGMNRLSLLARYGWYTKKVQDEIRGKVKSLLNDNGGFPKGKLQAVVKLTLDARGVVVDHRIVGSSGDTRMDEAVRKSLGLIRISEAPPADMPRTMTIKISSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VT7</accession>
    <name>Q39VT7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511664.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1403"/>
    <dbReference type="EnsemblBacteria" id="ABB31637">
        <property type="protein sequence ID" value="ABB31637"/>
        <property type="gene ID" value="Gmet_1403"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1403"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="NVFQQCV"/>
    <dbReference type="OrthoDB" id="1833499at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="296" mass="32351" checksum="E3E8360FA4AB073F" modified="2005-11-22" version="1">MTDNIEIDIANLGKTYRGKKHTIVQALKGLNIAIRKGEVFGFLGPNGAGKSTTIKILTGQIKGSEGSATIQGVPVEDPTSRKKLGYLPENPSFYDFLTAREYLRLVGNAYGMSPNAISCSTGEVLAKLELEHAADRPIRGYSKGMVQRLGLAQAMLADPELLILDEPMSGLDPLGRALVKDLIKELKQAGKTIFFSTHITADVEIVCDRVGILVGGELKALDRVESILDQGIDGYRLSFAAAEERTIEQLVAVDELKATLEHILAQGGRIERIEPLRRDLERYFLDVVKGTNHEHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VY4</accession>
    <name>Q39VY4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">23S rRNA (2'-O-methyl-G2251)-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rlmB</name>
        <name evidence="4" type="ordered locus">Gmet_1356</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365818.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1356"/>
    <dbReference type="EnsemblBacteria" id="ABB31590">
        <property type="protein sequence ID" value="ABB31590"/>
        <property type="gene ID" value="Gmet_1356"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1356"/>
    <dbReference type="eggNOG" id="COG0566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021322_0_1_7"/>
    <dbReference type="OMA" id="QVPPYEY"/>
    <dbReference type="OrthoDB" id="1422015at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004441">
        <property type="entry name" value="rRNA_MeTrfase_TrmH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46429">
        <property type="entry name" value="PTHR46429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00186">
        <property type="entry name" value="rRNA_methyl_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SpoU_sub_bind" evidence="3">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="250" mass="26819" checksum="4371C92261233310" modified="2005-11-22" version="1">MKEEILYGINSAMEALRGKRRAFELFVSRDASDRRMEKLLKLATEKGVPVRNRDKRDISRLCGTDHHQGVALKLEGFPYTGLSDIIDAWRESGERGLILALDGVQDPHNLGALIRSAACAGAHGVIIPKDRAARVTATVEKSAAGAAETIPVAQVTNLAQALDELKEAGFWIYGAADSAASSLYDQDLSGNVVIVIGSEGEGVRPLVRKKCDFLVAIPLRGGVSSLNASVAGGVILFEVLRQRLAFSPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WC7</accession>
    <name>Q39WC7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512160.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1210"/>
    <dbReference type="EnsemblBacteria" id="ABB31447">
        <property type="protein sequence ID" value="ABB31447"/>
        <property type="gene ID" value="Gmet_1210"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1210"/>
    <dbReference type="eggNOG" id="COG1858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034652_0_1_7"/>
    <dbReference type="OMA" id="QGGLFWD"/>
    <dbReference type="OrthoDB" id="52724at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004852">
        <property type="entry name" value="Di-haem_cyt_c_peroxidsae"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03150">
        <property type="entry name" value="CCP_MauG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223560" evidence="5">
        <location>
            <begin position="23"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="244"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="453" mass="49011" checksum="6F09B173BE46A649" modified="2005-11-22" version="1">MVTTRLLAAAATLLLTAGGAAAGTSELTCKEAVGKKIFFDQRLSVNKNQACAACHAPEVGWTGPDQEINKHGAVYEGSIAGQFGNRKPPSSAYATTSPFFRLVNVSDAAFAGGNFWDGRATGAKLGNPAADQAQGPFLNPKEQALPDAACVVYRVCNSPDYGMLFQQVWPGACDIDWPTTIDFESACSNPSQGPFSLDAMTRAKVDVAYNDVAYAIAAFEDSKEVNAFSSKYDQYLKGKAGLSDKEKWGLALFNGKGKCANCHISTVERKCASGIDCAASRCPDVADDCGKSSPLFTDYTFDNLGVPKNPENPFYGQPEGGSGWIDPGLGGFLNSRMDFAMYADKNYGKHKVPTLRNVDKRPYPMFVKDYGHNGYFKSLKEIVHFYNTRDKFPTCNPGDPGEKMTCWPAPEVSDNVNKTELGNLGLSDMEEDAIVAFMKTLSDGYRHSNQDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WJ6</accession>
    <name>Q39WJ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513404.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1140"/>
    <dbReference type="EnsemblBacteria" id="ABB31378">
        <property type="protein sequence ID" value="ABB31378"/>
        <property type="gene ID" value="Gmet_1140"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1140"/>
    <dbReference type="eggNOG" id="COG3299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_705480_0_0_7"/>
    <dbReference type="OMA" id="AICDNDP"/>
    <dbReference type="OrthoDB" id="1178209at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="391" mass="44509" checksum="00C36A2E1CDD3C2B" modified="2005-11-22" version="1">MAENPKSILTFEGRCPDCAERRVELPQPLPEPGDDFDWLARDYDSFRRLMLEELAGRFPERTRWTAGDLEVVLVEALAAVLDQLSDTADRVATEAYLETARRPESVRRLLSLIGYDAATAAGLEDDPPATPDGKSRHQKLDELWRRNPLLMDPARLEGPRAIHTQRRMVTVADYADRLTDHPLVLRASGWSAWTGSWPTVRVATVLWNDHPLDEEGLPYPDDLRERVMAFHQEHRIWEPVWEPEPPTIRTILRPYLEAWRMAGQEVVLEDAVPVGIKMFISIRVRENYFQSEVRNAVHQALGTGPGGFFEPGRHDFGEDLYASDLFQTLMSLNGVENVCLNRFKRFGDQYPDQTDTGRIPLQGLEIAVCDNDPSRPERGYINLTLTGGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WJ7</accession>
    <name>Q39WJ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage baseplate outer wedge protein (Acidic lysozyme), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513403.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1139"/>
    <dbReference type="EnsemblBacteria" id="ABB31377">
        <property type="protein sequence ID" value="ABB31377"/>
        <property type="gene ID" value="Gmet_1139"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1139"/>
    <dbReference type="eggNOG" id="COG3628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_133204_0_2_7"/>
    <dbReference type="OMA" id="HTERNTY"/>
    <dbReference type="OrthoDB" id="1791538at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="26"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="124" mass="13852" checksum="85528BF2C75326BC" modified="2005-11-22" version="1">MNRLADPPYMAFPLRIGDHGAATADRRSHVRQQIEQVLFTNPGERVFRPDFGAGLKQLVFEPNSSVLWEITRKRISSSLAEALRGEVDPKSLEVDVRGEGEKLLITVSYALAAIGHGERHEFLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WJ8</accession>
    <name>Q39WJ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phage tail spike protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513402.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1138"/>
    <dbReference type="DNASU" id="3741345"/>
    <dbReference type="EnsemblBacteria" id="ABB31376">
        <property type="protein sequence ID" value="ABB31376"/>
        <property type="gene ID" value="Gmet_1138"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1138"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019505_1_0_7"/>
    <dbReference type="OMA" id="FATHVHT"/>
    <dbReference type="OrthoDB" id="1880900at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="1">
        <location>
            <begin position="20"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="270" mass="28749" checksum="7D3562C54A69C3EC" modified="2005-11-22" version="1">MDDLLLELARQYRNRYYGKYRGFVTDNDDPEQRGRLRLMVPSVLGETPTGWALPSLPFGGLADQGLFMVPEVDAQVWVEFEAGNVNLPIWTGTFWQASGDPPAEAAKSPPTTRVLKTPSGHILQFDDESGAEKFRLAHPAGTEMTVDEKGTVIVADAKGNTLTLDADAGKVVVEDSNGNTITMSSSGTTIEDANGNKVEMAASGVTVKGQQVVVDAQTVMLAGQGGEPIIKGQSFLTLFATHVHPSAMGPTGPPIPQGEMSTLSMKVMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WL8</accession>
    <name>Q39WL8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATP/GTP-binding transposition helper of ISGme4, IS21 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0320</name>
        <name evidence="3" type="ordered locus">Gmet_1117</name>
        <name evidence="4" type="ordered locus">Gmet_1788</name>
        <name evidence="5" type="ordered locus">Gmet_2273</name>
        <name evidence="6" type="ordered locus">Gmet_2538</name>
        <name evidence="7" type="ordered locus">Gmet_2587</name>
        <name evidence="8" type="ordered locus">Gmet_2796</name>
        <name evidence="9" type="ordered locus">Gmet_3281</name>
    </gene>
    <organism evidence="3 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514800.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0320"/>
    <dbReference type="EnsemblBacteria" id="ABB30563">
        <property type="protein sequence ID" value="ABB30563"/>
        <property type="gene ID" value="Gmet_0320"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31356">
        <property type="protein sequence ID" value="ABB31356"/>
        <property type="gene ID" value="Gmet_1117"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32019">
        <property type="protein sequence ID" value="ABB32019"/>
        <property type="gene ID" value="Gmet_1788"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32499">
        <property type="protein sequence ID" value="ABB32499"/>
        <property type="gene ID" value="Gmet_2273"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32757">
        <property type="protein sequence ID" value="ABB32757"/>
        <property type="gene ID" value="Gmet_2538"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32806">
        <property type="protein sequence ID" value="ABB32806"/>
        <property type="gene ID" value="Gmet_2587"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33014">
        <property type="protein sequence ID" value="ABB33014"/>
        <property type="gene ID" value="Gmet_2796"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33494">
        <property type="protein sequence ID" value="ABB33494"/>
        <property type="gene ID" value="Gmet_3281"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0320"/>
    <dbReference type="KEGG" id="gme:Gmet_1117"/>
    <dbReference type="KEGG" id="gme:Gmet_1788"/>
    <dbReference type="KEGG" id="gme:Gmet_2273"/>
    <dbReference type="KEGG" id="gme:Gmet_2538"/>
    <dbReference type="KEGG" id="gme:Gmet_2587"/>
    <dbReference type="KEGG" id="gme:Gmet_2796"/>
    <dbReference type="KEGG" id="gme:Gmet_3281"/>
    <dbReference type="eggNOG" id="COG1484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062999_1_0_7"/>
    <dbReference type="OMA" id="YLPMDRE"/>
    <dbReference type="OrthoDB" id="1792718at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028350">
        <property type="entry name" value="DNAC/ATP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002611">
        <property type="entry name" value="IstB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01695">
        <property type="entry name" value="IstB_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003073">
        <property type="entry name" value="DNAC_TnpB_IstB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="101"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="264" mass="29615" checksum="54D7A11513AB7B03" modified="2005-11-22" version="1">MSDIQHQRMVTLCDDLKFLAVTDVYADLADAAAKQESSYIDYLEQVLKAENDVRQGRSRHTMAKLAGFPAIKTLEDYDFDFATGAPKQRILDLSAMAFLERRENVILLGPSGTGKTHLAIALGYRATQCGVKVRFISAADLMLQLESAQRQGRYKEVMRRSVLGPRLLIIDEIGYLPFSETQANLFFQVIAKRYETGSVILTSNLSFGEWEQAFGGNTALTSAMLDRLLHHAHVIQIRGDSYRLKEKRRAGILGQQLPTPQMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WN9</accession>
    <name>Q39WN9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rubrerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513751.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1095"/>
    <dbReference type="DNASU" id="3738588"/>
    <dbReference type="EnsemblBacteria" id="ABB31335">
        <property type="protein sequence ID" value="ABB31335"/>
        <property type="gene ID" value="Gmet_1095"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1095"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138442_0_0_7"/>
    <dbReference type="OMA" id="CAELYHY"/>
    <dbReference type="OrthoDB" id="2140911at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="12"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="19087" checksum="173B28DCDAA92536" modified="2005-11-22" version="1">MARMSVDMMTVLHKCAEIELKSMELYDLYADCFTHDLDVARMWRRAAREEEDHANQFRLALKMRDGVIREVNLDPCRVEYILKELQFAIDRVKLSCPTLEEAFHSAIKLEEDLSGMHVQYVVDFEDEMCRKFFNALMMDDKIHVSRLREAYDRQTKTRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WS7</accession>
    <name>Q39WS7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Gmet_1057</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513232.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1057"/>
    <dbReference type="EnsemblBacteria" id="ABB31297">
        <property type="protein sequence ID" value="ABB31297"/>
        <property type="gene ID" value="Gmet_1057"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1057"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_21_7"/>
    <dbReference type="OMA" id="WSIHYTW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17202">
        <property type="entry name" value="sCache_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="351"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="452"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="391"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB31297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="673" mass="73491" checksum="11E951BF2836DA4D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WS8</accession>
    <name>Q39WS8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513231.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1056"/>
    <dbReference type="EnsemblBacteria" id="ABB31296">
        <property type="protein sequence ID" value="ABB31296"/>
        <property type="gene ID" value="Gmet_1056"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1056"/>
    <dbReference type="eggNOG" id="COG4914">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1460679_0_0_7"/>
    <dbReference type="OMA" id="YESENVS"/>
    <dbReference type="OrthoDB" id="1825441at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039498">
        <property type="entry name" value="NTP_transf_5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14907">
        <property type="entry name" value="NTP_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="186" mass="21105" checksum="D8E01C08315D50A0" modified="2005-11-22" version="1">MDFKSVLDKLLSSFDDQGIRYALIGGFALGLWGIDRSTADLDFLVLRDDMEKVDRILRDMGYNRTYESENVSHYTAPQAPLGGIDILHAFREASRAMLERAVDMDIFGGMLSMKVARPDDLIGLKVQAMANDERRRAMDLADIEALMALHASTLDWSLIGDYFSLFEMNDLFRELERNYHAQPEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WY4</accession>
    <name>Q39WY4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0998</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514691.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0998"/>
    <dbReference type="EnsemblBacteria" id="ABB31240">
        <property type="protein sequence ID" value="ABB31240"/>
        <property type="gene ID" value="Gmet_0998"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0998"/>
    <dbReference type="eggNOG" id="COG0600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046113_1_4_7"/>
    <dbReference type="OMA" id="VYASFWQ"/>
    <dbReference type="OrthoDB" id="1531811at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="61"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="28289" checksum="BEE74DBB96F1A222" modified="2005-11-22" version="1">MKSEQTKRAAIAVVLFYVLIFALWQLLFTAGMIPEYLFPSPVQVAKRLWELGADGYLLPSVEATLVRMGKGFTLAAAIGLSIGLVMGVSPITNLCFKSLFLGLQTLPTAAWVPISLLIYGLSERGIYFVIIMSSVPAMALATSSGILQIPPLYLRAAKTLGTPWYAMPARVILPAALPAIVTGLKLGWTLGWHGGVSAELIKSTIGLGFLLYMGRELNDAAQVMGIMVVTILFGLLLDRFFFGIIEQRIRIRWGLEKRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X09</accession>
    <name>Q39X09_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV pilus biogenesis protein PilO</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilO</name>
        <name evidence="3" type="ordered locus">Gmet_0973</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514368.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0973"/>
    <dbReference type="EnsemblBacteria" id="ABB31215">
        <property type="protein sequence ID" value="ABB31215"/>
        <property type="gene ID" value="Gmet_0973"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0973"/>
    <dbReference type="eggNOG" id="COG3167">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102444_0_0_7"/>
    <dbReference type="OMA" id="TARTFRY"/>
    <dbReference type="OrthoDB" id="1803493at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043107">
        <property type="term" value="P:type IV pilus-dependent motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007445">
        <property type="entry name" value="PilO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04350">
        <property type="entry name" value="PilO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="198" mass="22355" checksum="9A985D4B277DC0F2" modified="2005-11-22" version="1">MDPRIEKLLKLPKKQKIALLVAILLFEGAALYWGLFLPRQTELKELRGRLEGLQNEVREKERIANNLPKLKREYQQLQKDLDLALTELPNQKEIPSLLTGITSVGKSAGNDFLLFRPKPEVSKDFYAEVPVDISISGTFHSVANFFTAVGKLPRIVNITDVSFADIKQAGGKTSVKVNCLATTFRFLDKKETKDDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X14</accession>
    <name>Q39X14_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0968</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514362.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0968"/>
    <dbReference type="EnsemblBacteria" id="ABB31210">
        <property type="protein sequence ID" value="ABB31210"/>
        <property type="gene ID" value="Gmet_0968"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0968"/>
    <dbReference type="HOGENOM" id="CLU_2129856_0_0_7"/>
    <dbReference type="OrthoDB" id="2178506at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223399" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="113" mass="12410" checksum="768AE7D490C3789E" modified="2005-11-22" version="1">MRYLMVVAASLVFCVNLAVAGQDVHRGLPTLSSLGVNFTDLMTPEAHEGVVMEVRGAGSFILREKLYIICQESDVDGTPANQAKFSLKKGDTVKATVYRLPNKTYFVSELEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X16</accession>
    <name>Q39X16_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type IV pilus minor pilin PilX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pilX-2</name>
        <name evidence="1" type="ordered locus">Gmet_0966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514360.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0966"/>
    <dbReference type="EnsemblBacteria" id="ABB31208">
        <property type="protein sequence ID" value="ABB31208"/>
        <property type="gene ID" value="Gmet_0966"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0966"/>
    <dbReference type="HOGENOM" id="CLU_1584126_0_0_7"/>
    <dbReference type="OrthoDB" id="2138406at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="173" mass="18270" checksum="AD58F8CE9FD5BB95" modified="2005-11-22" version="1">MVIRGTRKKWFLMRMGDQTGMALVTVITFAAVLMAMMTMMLNTTMVETVLAGASTVSKRTLVAADAGLQFVRGTFVYMGSNGFPASSSTGNLTAQGQAQLPAPLNQKVTFLNLTGMGVDSNLLVGSGFSSRYVAPTAGGGALVLKPYRSRTVARAENGTSRKIVEFEGFSLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X29</accession>
    <name>Q39X29_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2914 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31195.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0953"/>
    <dbReference type="EnsemblBacteria" id="ABB31195">
        <property type="protein sequence ID" value="ABB31195"/>
        <property type="gene ID" value="Gmet_0953"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0953"/>
    <dbReference type="HOGENOM" id="CLU_141686_1_0_7"/>
    <dbReference type="OMA" id="KITEMAV"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022606">
        <property type="entry name" value="DUF2914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11141">
        <property type="entry name" value="DUF2914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223379" description="DUF2914 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2914" evidence="2">
        <location>
            <begin position="74"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31195.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="135" mass="15344" checksum="89C2A74099684F1C" modified="2012-10-31" version="2">MRKLFAFLTAFWLCLPGATASMAAEGGSLRITEMAVTTKVSRNNPIDAVRRINHRSVPALYCFTRIVNPSGEETPIRHVWYRNGEVVGEQELQVKGQKWRTWSKRPIDRDSIGTWRVEALDSAGKLLKAVEFRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X48</accession>
    <name>Q39X48_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">[acyl-]glycerolphosphate acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514417.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0934"/>
    <dbReference type="EnsemblBacteria" id="ABB31176">
        <property type="protein sequence ID" value="ABB31176"/>
        <property type="gene ID" value="Gmet_0934"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0934"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_4_5_7"/>
    <dbReference type="OMA" id="SNHISAY"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PlsC" evidence="1">
        <location>
            <begin position="42"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="217" mass="24277" checksum="44CF18D86F88A696" modified="2005-11-22" version="1">MKASLVRRVWVTFSAHVIGFYASTLNRFRVKGIENLPKDGGVLIASNHISAYETIFIPWAVLRHYPLQMVWAPAKEELFTSRLQQWLYSSWGAFPVKRGRDIRAGKVINDLLLTEKVMLFPEGTRHKDGVLGPGNRGVGKIIYDTRPTVVPTALVGLNRWKFPGVGQDAAIVFGKPLDFADLYGREDNKETHQLIVGRVMTAIADLLKTEGAYVNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X68</accession>
    <name>Q39X68_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513944.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0914"/>
    <dbReference type="EnsemblBacteria" id="ABB31156">
        <property type="protein sequence ID" value="ABB31156"/>
        <property type="gene ID" value="Gmet_0914"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0914"/>
    <dbReference type="eggNOG" id="ENOG5033743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122328_0_0_7"/>
    <dbReference type="OrthoDB" id="1519144at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223580" evidence="2">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="151" mass="16235" checksum="E3A16072FA12F2F1" modified="2005-11-22" version="1">MKKIVLFLLALTFTATAALAAGGLDYFLGNLNVQARADMSGFAGRLSAQFGVPGVQVSATLGTVKEPADAFMIYQLGQMTHQPYQRVLQTYQSNRGKGWGVIARSLGIKPGSAEFHALKRGDFALTGRPGSTWEQRDDYGKGKGRGKGHNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XA2</accession>
    <name>Q39XA2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PppGpp 5'-phosphohydrolase and exopolyphosphatase, HD domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gppA-2</name>
        <name evidence="3" type="ordered locus">Gmet_0880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513026.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0880"/>
    <dbReference type="EnsemblBacteria" id="ABB31122">
        <property type="protein sequence ID" value="ABB31122"/>
        <property type="gene ID" value="Gmet_0880"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0880"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_4_2_7"/>
    <dbReference type="OMA" id="WQICVGA"/>
    <dbReference type="OrthoDB" id="1862004at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030673">
        <property type="entry name" value="PyroPPase_GppA_Ppx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001267">
        <property type="entry name" value="Pyrophosphatase_GppA_Ppx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="2">
        <location>
            <begin position="22"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="337"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="513" mass="55848" checksum="42900D8A2C0B8C28" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XC2</accession>
    <name>Q39XC2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513006.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0860"/>
    <dbReference type="EnsemblBacteria" id="ABB31102">
        <property type="protein sequence ID" value="ABB31102"/>
        <property type="gene ID" value="Gmet_0860"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0860"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038798_0_0_7"/>
    <dbReference type="OMA" id="APYGIQM"/>
    <dbReference type="OrthoDB" id="1025063at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223587" evidence="2">
        <location>
            <begin position="29"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="69"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="529" mass="58509" checksum="3EFFC07027F22220" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XD0</accession>
    <name>Q39XD0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="synonym">tgt-2</name>
        <name evidence="6" type="ordered locus">Gmet_0852</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512997.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0852"/>
    <dbReference type="EnsemblBacteria" id="ABB31094">
        <property type="protein sequence ID" value="ABB31094"/>
        <property type="gene ID" value="Gmet_0852"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0852"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_7"/>
    <dbReference type="OMA" id="GIDLFDC"/>
    <dbReference type="OrthoDB" id="1165356at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="12"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="90"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="244"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="268"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="370" mass="41930" checksum="618FF220FE07DA2A" modified="2005-11-22" version="1">MIHFKLIKKDGAARLGSLTTPRGTIETPIFMPVGTQATVKAMTPEELKTIGARIILANTYHLYIRPGHELVRRMGGLHRFMNWDRPILTDSGGFQVFSLNELRKITEEGVKFRSHLDGSYHFISPEDAIAIQGALGSDIAMCFDECTPYPATHDYARRSMEMTTRWARRCKDAKTREDQALFGIVQGGMYRDLRERSAAELREIGFDGYAMGGLSVGEEKEVMHEVLEYAAPMLPEDRPRYVMGIGAPEDLIEAVWHGFDMFDCVMPTRNARNGMLFTSFGRVNIKGAAYAEDAGPLDSECDCYVCRTYSRAYLRHLYRSGEILASRLNTYHNLYYYLSLMAKARAAIAEGRFAAFRQEFYAKRELQGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XM2</accession>
    <name>Q39XM2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Quinone biosynthesis kinase AarF, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513505.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0760"/>
    <dbReference type="EnsemblBacteria" id="ABB31002">
        <property type="protein sequence ID" value="ABB31002"/>
        <property type="gene ID" value="Gmet_0760"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0760"/>
    <dbReference type="eggNOG" id="COG0661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006533_0_2_7"/>
    <dbReference type="OMA" id="ADTFRRN"/>
    <dbReference type="OrthoDB" id="678616at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="ABC1" evidence="2">
        <location>
            <begin position="100"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="561" mass="63695" checksum="BF5EB7F8759D0FE5" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XM8</accession>
    <name>Q39XM8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flotillin band_7_5 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0754</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513499.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0754"/>
    <dbReference type="EnsemblBacteria" id="ABB30996">
        <property type="protein sequence ID" value="ABB30996"/>
        <property type="gene ID" value="Gmet_0754"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0754"/>
    <dbReference type="eggNOG" id="COG4260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037108_0_0_7"/>
    <dbReference type="OMA" id="GTMVYGD"/>
    <dbReference type="OrthoDB" id="886332at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03408">
        <property type="entry name" value="SPFH_like_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025874">
        <property type="entry name" value="DZR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033880">
        <property type="entry name" value="SPFH_YdjI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13421">
        <property type="entry name" value="Band_7_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12773">
        <property type="entry name" value="DZR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Band_7_1" evidence="5">
        <location>
            <begin position="33"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="DZANK-type" evidence="4">
        <location>
            <begin position="304"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="353" mass="37540" checksum="89AD899C67FEE9ED" modified="2005-11-22" version="1">MAINDMNAVFLEVIEWFDDSGREMVRRIPPQGSAEIKFGSQLVVRESQRAVFFKDGKVADCFGPGRHTLTSANLPILTKLLALPWGFTSPFRCEVCFVGMHTFTDLRWGTKEPVPFRDSRFGMVRLRAFGSYTLRVVEPQLLVNALVGTRGLYTAAELEEFFRDIIVARLNDYLGETIDTVLDLPARYDEMASALKERLAGDFGGFGIEMAELYVNAITPPPEVQKVIDERSSMEAAGDVDRYLKFKAAQSLEKAASAEGGGEAAQGMGLGLGAGLGMILPGMVANAMGGGGAKPAPAPAGGGCPRCATPLVAGARFCHQCGAAAEPGFCAGCGKELPGDARFCPGCGRPAGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XN9</accession>
    <name>Y743_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable transcriptional regulatory protein Gmet_0743</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_0743</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TACO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514460.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XN9"/>
    <dbReference type="SMR" id="Q39XN9"/>
    <dbReference type="STRING" id="269799.Gmet_0743"/>
    <dbReference type="EnsemblBacteria" id="ABB30985">
        <property type="protein sequence ID" value="ABB30985"/>
        <property type="gene ID" value="Gmet_0743"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0743"/>
    <dbReference type="eggNOG" id="COG0217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062974_2_2_7"/>
    <dbReference type="OMA" id="ETIMYEG"/>
    <dbReference type="OrthoDB" id="1304328at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00693">
        <property type="entry name" value="Transcrip_reg_TACO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017856">
        <property type="entry name" value="Integrase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002876">
        <property type="entry name" value="Transcrip_reg_TACO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026564">
        <property type="entry name" value="Transcrip_reg_TACO1-like_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029072">
        <property type="entry name" value="YebC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12532">
        <property type="entry name" value="PTHR12532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01709">
        <property type="entry name" value="Transcrip_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75625">
        <property type="entry name" value="SSF75625"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01033">
        <property type="entry name" value="TIGR01033"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000257069" description="Probable transcriptional regulatory protein Gmet_0743">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00693"/>
        </source>
    </evidence>
    <sequence length="247" mass="27301" checksum="4929E08FD20B2930" modified="2005-11-22" version="1">MSGHNKWSTIKHKKGAADAKRGKVFTKIIKEITVAAKLGGGDPNGNPRLRSAVDKAKAENMPKDNIERAIKKGTGELEGVNYEEIVYEGYGPGGVAVLVECMTDNRNRTVGDVRSTFTKCNGNMGETGCVSWMFDKKGLIVVSKDADFEKLFEVALEAGAEDVADEEEQYEVLTDPSSFMEVREALEKAGFAHESAEITMIPQTMVKLDGKNAENMLKLMDRLEDNDDVQNVYANFDISMEEMEKLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XR7</accession>
    <name>Q39XR7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0715</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514620.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0715"/>
    <dbReference type="EnsemblBacteria" id="ABB30957">
        <property type="protein sequence ID" value="ABB30957"/>
        <property type="gene ID" value="Gmet_0715"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0715"/>
    <dbReference type="eggNOG" id="ENOG50316CZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145369_0_0_7"/>
    <dbReference type="OMA" id="QAFYIEP"/>
    <dbReference type="OrthoDB" id="1844199at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="DUF4149"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4149" evidence="5">
        <location>
            <begin position="10"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="146" mass="15874" checksum="D17EE927B7068A60" modified="2005-11-22" version="1">MSFFSVLCRLAVALWVGGAALFTFVLTPTIFRTETRDVAGRIVGYLFPGYFRWGLACGAVALLALLLARGKNWMPAAVLLVVMLAVTAFQAFHVEPKAALIKQQIPSFETTPKDHPMRREFSKLHGISAVCNLSVIAGGVVLIILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XU7</accession>
    <name>Q39XU7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein-associated cytochrome b and CCG domain pair iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0685</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514076.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0685"/>
    <dbReference type="EnsemblBacteria" id="ABB30927">
        <property type="protein sequence ID" value="ABB30927"/>
        <property type="gene ID" value="Gmet_0685"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0685"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_7"/>
    <dbReference type="OMA" id="SGCPYCL"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="264"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="659" mass="73185" checksum="0AA6A49F724E3486" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y29</accession>
    <name>LEU3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.85</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">3-IPM-DH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Beta-IPM dehydrogenase</fullName>
            <shortName evidence="1">IMDH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuB</name>
        <name type="ordered locus">Gmet_0602</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514732.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y29"/>
    <dbReference type="SMR" id="Q39Y29"/>
    <dbReference type="STRING" id="269799.Gmet_0602"/>
    <dbReference type="EnsemblBacteria" id="ABB30845">
        <property type="protein sequence ID" value="ABB30845"/>
        <property type="gene ID" value="Gmet_0602"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0602"/>
    <dbReference type="eggNOG" id="COG0473">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031953_0_3_7"/>
    <dbReference type="OMA" id="EYDLGAR"/>
    <dbReference type="OrthoDB" id="1551125at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01033">
        <property type="entry name" value="LeuB_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="PTHR42979"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0432">Leucine biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000250117" description="3-isopropylmalate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="285"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="1">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01033"/>
        </source>
    </evidence>
    <sequence length="362" mass="39000" checksum="D6498413459AECC6" modified="2005-11-22" version="1">MSQVFKVAVLPGDGIGPEVMAEALRVLDAIEKKYDVKFERTHANVGGAGIDLEGKALPETTITICKTSDAILFGSVGGPKWETLPPDEQPERGALLPLRKIFGLYANLRPAIIFPSLTGASSLKEEVIAGGFNVLVIRELTGGIYFAQPKGIEGEGRDRVGFDTMRYSVPEIERITHVAFQAARKRGKKVCSIDKANVLSSSVLWREVVTGIAKEYPDVELSHMYVDNAAMQLVRWPKQFDVILCENMFGDILSDEAAMLTGSLGMLPSASLAEGTFGMYEPSGGSAPDIAGQGIANPIAQILSMGMMLRFSFGMVDAADAIDNAVAKVLDQGCRTRDIFQEKPGEKLVNTKEMGDAIIVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y39</accession>
    <name>Q39Y39_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ResB-like family cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0592</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512290.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0592"/>
    <dbReference type="EnsemblBacteria" id="ABB30835">
        <property type="protein sequence ID" value="ABB30835"/>
        <property type="gene ID" value="Gmet_0592"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0592"/>
    <dbReference type="eggNOG" id="COG1333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_612182_0_0_7"/>
    <dbReference type="OMA" id="FSTWEQF"/>
    <dbReference type="OrthoDB" id="1055167at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="11"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="439" mass="49111" checksum="9021001C48768613" modified="2005-11-22" version="1">MLKRFFLSRKTVISLILLMLGAILLGYSFPQRFLTSPPELDKWQLANPALAKLSRVLALDHVYTSPWFAVLLVLFLVSLCFSTWEQFRLALRKSREGGAGGESFESAAGAAELAAGLRSLGYLRMGGRDGATRFVRHPWGYWGNFLLHLGIVVSIASSLVILLYEKRAVIDLLEGEVHKPGADWIKEERGLLAGKLVLPDAVRLDRVVPEYYDNDNMRQLTTDFSFVDAAGRPTPLSMHINKSIRYKGVRIFQGKSYGRAFFVKFTGQDGQEHGEVFSLDQPTDRNTASYKDFVLPWLPSALKTKYYGDADRRSLDGSNPLFVMRLMEGGKAVAELPLKVGETGRLGGYTAQLVKVERWGGLIFIDTTGMAGIFLGFFIVCLGGSLSYFCPPRECSLSPSGEGCRLSWRATRFERLYRDEFDYLRRLAGLPVATDERNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y90</accession>
    <name>Q39Y90_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Menaquinol oxidoreductase complex Cbc6, lipoprotein cytochrome c subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cbcR</name>
        <name evidence="7" type="ordered locus">Gmet_0541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30784.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512237.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0541"/>
    <dbReference type="EnsemblBacteria" id="ABB30784">
        <property type="protein sequence ID" value="ABB30784"/>
        <property type="gene ID" value="Gmet_0541"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0541"/>
    <dbReference type="eggNOG" id="COG3474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056727_0_0_7"/>
    <dbReference type="OMA" id="FACRRCH"/>
    <dbReference type="OrthoDB" id="1397220at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223436" evidence="5">
        <location>
            <begin position="23"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="167"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30784.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="263" mass="28699" checksum="10E07FE474EE2C45" modified="2012-10-31" version="2">MVARLPLLILLCLVLAACVGKAPGEGCLSCHPSHYAERGSCVSCHRGNGKSVRKAIAHHRLIPAELAHFTVPGSRRVEEGKRLVERFGCRRCHNLGGKGTRLAADLDRLAGDDPVRLFGAIKRPVLFMPDFHFDDRQTAGLVNAVMAFAAKAPRPVSGGLPVVVHFASPQQGEKNIFEKKCGGCHRLLTAREGALGNGDVAPNLSGLFTPFYPTPFKPGEPWTPERLGRWLDNPRAVRPDTPMPPVRLSLTEKKQLTEMLKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YB4</accession>
    <name>Q39YB4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trx-2</name>
        <name evidence="3" type="ordered locus">Gmet_0517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512213.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0517"/>
    <dbReference type="EnsemblBacteria" id="ABB30760">
        <property type="protein sequence ID" value="ABB30760"/>
        <property type="gene ID" value="Gmet_0517"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0517"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_13_0_7"/>
    <dbReference type="OMA" id="ARTCIPC"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223461" evidence="1">
        <location>
            <begin position="19"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="125" mass="13867" checksum="FF570E751CF09087" modified="2005-11-22" version="1">MRFLTLLFLLLTATVARAELPSATDDAINKALASGKPAVIDLGARYCIPCKKMAPILESLATEYRGKATVLFIDVNENQAAPKRFRVQMIPTQIFFDARGKEVKRHMGFMDKADIVKELNALGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YI0</accession>
    <name>Q39YI0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Uronate isomerase</fullName>
            <ecNumber evidence="4 6">5.3.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Glucuronate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Uronic isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">uxaC</name>
        <name evidence="7" type="ordered locus">Gmet_0451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>D-glucuronate = D-fructuronate</text>
            <dbReference type="Rhea" id="RHEA:13049"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="ChEBI" id="CHEBI:59863"/>
            <dbReference type="EC" id="5.3.1.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>aldehydo-D-galacturonate = keto-D-tagaturonate</text>
            <dbReference type="Rhea" id="RHEA:27702"/>
            <dbReference type="ChEBI" id="CHEBI:12952"/>
            <dbReference type="ChEBI" id="CHEBI:17886"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate metabolism; pentose and glucuronate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.12" evidence="4 6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513819.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0451"/>
    <dbReference type="EnsemblBacteria" id="ABB30694">
        <property type="protein sequence ID" value="ABB30694"/>
        <property type="gene ID" value="Gmet_0451"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0451"/>
    <dbReference type="eggNOG" id="COG1904">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044465_1_0_7"/>
    <dbReference type="OMA" id="TDHGHPT"/>
    <dbReference type="OrthoDB" id="167900at2"/>
    <dbReference type="UniPathway" id="UPA00246"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008880">
        <property type="term" value="F:glucuronate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006064">
        <property type="term" value="P:glucuronate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00675">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003766">
        <property type="entry name" value="Uronate_isomerase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02614">
        <property type="entry name" value="UxaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="473" mass="53969" checksum="A2F365C3C1AE336F" modified="2005-11-22" version="1">MTIRRNFTASVRENALTLYERHASLPIIDYHGHLPPARLASNAHFRDLSELWIEGDHYKWRAMRIAGEREDLCTGSASPKERFDAWARTITRMASSPMQAWCQIELKRTFGITAPLTPSSAECIWEEANSMLATENFRPRKLLARAGVEVLCTTDDPADQLEAHRQLVEDKEVSFRVFPTFRPDSALCLHTRQNFHDWRSRLEACSGIAIESLQTFMEALRVRYEFFHKLGCRVSDHGMDRCYATPCSDAEATTIFSRLLLSSSDIDADDLEKWRSWFMRQIAEWNHESGWTMMLHLGARRNNNTRIFSSYGLDAGCDSIGDFPQGESLVAFLDQLDTSERLPKTILFNSNPRDTLMFATIAGSFWGEGIRGKVQHGPPWWFLDQIYGIEDHLNAQCAVGVLGTFVGMASDSRSFLSTARHEYFRKAITLRLADDLESGLFNPDQVDIDEFCRDLFYANAQSFFGWKVAHGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YK2</accession>
    <name>Q39YK2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA polymerase sigma-28 factor for flagellar operon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fliA</name>
        <name evidence="6" type="ordered locus">Gmet_0429</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512401.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0429"/>
    <dbReference type="EnsemblBacteria" id="ABB30672">
        <property type="protein sequence ID" value="ABB30672"/>
        <property type="gene ID" value="Gmet_0429"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0429"/>
    <dbReference type="eggNOG" id="COG1191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_8_1_7"/>
    <dbReference type="OMA" id="IKFETYA"/>
    <dbReference type="OrthoDB" id="1857862at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012845">
        <property type="entry name" value="RNA_pol_sigma_FliA_WhiG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000770">
        <property type="entry name" value="RNA_pol_sigma-SigE/K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02479">
        <property type="entry name" value="FliA_WhiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00716">
        <property type="entry name" value="SIGMA70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="5">
        <location>
            <begin position="216"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="250" mass="28840" checksum="3E953DA60245FB46" modified="2005-11-22" version="1">MNCLVKAYEQEAQRSSAQSRDELIVTHLPLVKFLVGRIATQLPPHLDQDDLMSAAVIGLITAAERFDPSRGVQFKTFAEQRIRGTIIDELRSQDWLTRSLRDKFKKLEREFVMLEHRLGRNPTSEEVAKSLEISVDDYHHMLEEIHLLSFVSLDESWEDEDGSPFGLLDILEDKGVENPQSQLMARQMLDTLTEAIEGLPEKERLVITFYYYEELNLKEIGAVLDLSESRISQLHSQAIVRLRAKMKNMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YU5</accession>
    <name>Q39YU5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">moeA-2</name>
        <name evidence="9" type="ordered locus">Gmet_0336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512308.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0336"/>
    <dbReference type="EnsemblBacteria" id="ABB30579">
        <property type="protein sequence ID" value="ABB30579"/>
        <property type="gene ID" value="Gmet_0336"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0336"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_0_7"/>
    <dbReference type="OMA" id="VDHVHPT"/>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01079">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="173"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="402" mass="42699" checksum="3BCD6FA53D2A4B71" modified="2005-11-22" version="1">MISIEEAQQIILSHTGLLGTEEVPLLHALHRVIAEDVHAPWDIPGADHSAMDGYTFAYDDVQGGSLEVCGFLPAGVAPTEPVSPGCAMKIMTGAPIPPGCDTVVPVEDVLEEGTTIRLRGMVKRGDHIRRRGEEVNAGDLVVASGSLLRPPEIGILSSLGKTTATVFRKARVAVLSTGDELLQPGSIPEPGKIINSNSTSIAAQLLEAGAEPLMLGIARDDLETTRRKISDGLQADLLVTTGGVSVGDRDFVRDALLDLGGEIKFWKVAMKPGKPVAFAMVRGKPVFALPGNPVAAMVAFEQFVRPALLTMMGHARILRPVVRGTLEEAIRNRGGRPHFVRVSVRLEAGRYRLATTGDQGSARLSSLTSGNGLVKLPPDAAIVAGSEVEVQLLDRHFEMGHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YY5</accession>
    <name>Q39YY5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrite reductase (cytochrome; ammonia-forming)</fullName>
            <ecNumber evidence="2">1.7.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nrfA-1</name>
        <name evidence="10" type="ordered locus">Gmet_0294</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>6 Fe(III)-[cytochrome c] + 2 H2O + NH4(+) = 6 Fe(II)-[cytochrome c] + 8 H(+) + nitrite</text>
            <dbReference type="Rhea" id="RHEA:13089"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.7.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome c-552 family.</text>
    </comment>
    <dbReference type="EC" id="1.7.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514005.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0294"/>
    <dbReference type="EnsemblBacteria" id="ABB30539">
        <property type="protein sequence ID" value="ABB30539"/>
        <property type="gene ID" value="Gmet_0294"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0294"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035040_1_0_7"/>
    <dbReference type="OMA" id="GQCHASV"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042279">
        <property type="term" value="F:nitrite reductase (cytochrome, ammonia-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00548">
        <property type="entry name" value="NrfA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003321">
        <property type="entry name" value="Cyt_c552"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30633">
        <property type="entry name" value="PTHR30633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02335">
        <property type="entry name" value="Cytochrom_C552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000243">
        <property type="entry name" value="Cyt_c552"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223459" description="Nitrite reductase (cytochrome; ammonia-forming)" evidence="9">
        <location>
            <begin position="31"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="488" mass="54587" checksum="E55DEA5EAE10EF70" modified="2005-11-22" version="1">MRRLNPVAPLIALAAAATLFVLGGCAPEKAQPVKTVQIPDGEVDPAVWGKAYPTEYEMWKKTEEPEPPGKSKYKRGFDADHVTYDKLSEFPYMALLFNGWGFGIAYNEPRGHANMVRDQLEIDSARLKSGGVCLTCKTPYAPKLEKEMGIDYFKTPFKDVLAKIPEKHKTLGVACIDCHDNKDMSLRISRGFTLGEALKKLGVDQAKLSRQEMRSLVCAQCHVTYNIPKDADKKSIGVYFPWQGSKMGNISVENIIKQIRSDASVGEWTQTVTGFKLGFIRHPEYELFSNNSVHWKAGAACTDCHMPYTRVGAFKVSDHRVMSPLKNDMKACIQCHTEKPEWLRDQVIAIQDRTVSLMLRSGYATATVAKLFEKAHAAQAQGKQIDKALYDRAKDLYEEAFYRCVFIGAENSVGFHNPTEAMRVLGDATAFATKAEALLRQALAKAGVDVPLTVNLELNKYLDQRGEKKLTFDPKVEIKDPYGVQVRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z09</accession>
    <name>Q39Z09_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-allo-threonine aldolase, stereospecific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ltaA</name>
        <name evidence="6" type="ordered locus">Gmet_0270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513587.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0270"/>
    <dbReference type="EnsemblBacteria" id="ABB30515">
        <property type="protein sequence ID" value="ABB30515"/>
        <property type="gene ID" value="Gmet_0270"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0270"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029381_0_3_7"/>
    <dbReference type="OMA" id="NKGGGAC"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023603">
        <property type="entry name" value="Low_specificity_L-TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF9">
        <property type="entry name" value="PTHR48097:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017617">
        <property type="entry name" value="Thr_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="5">
        <location>
            <begin position="5"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR017617-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="339" mass="35858" checksum="3689BB8D6BB62F21" modified="2005-11-22" version="1">MKIIDLRSDTVTRPCPAMRAAMAVAEVGDDVYGEDPTVNRLEALAAGMLGTEAALFVTSGTQSNLLAIMTHCGRGDEYIAGQTAHCYRFEGGGAAVLGGVQPQPVDVEPDGTLDLVKVAAAIKPNDPHFARTRLLCLENTQAGRVLPLDYLARARTLARERGLALHLDGARLFNAAVALDVEAREITDHFESVSVCLSKGLGAPVGSLLCGSRGFVAEARRWRKVLGGGMRQAGVLAAAGIVALTENVARLAEDHANARRLAEGLAAVGGLDGDSVSVQTNMVFLSLPPDHAEALATFLCDRGVLISGRERIRLVTHRDVTSADIDRVVGACGEFFRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZA7</accession>
    <name>Q39ZA7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512757.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0170"/>
    <dbReference type="EnsemblBacteria" id="ABB30417">
        <property type="protein sequence ID" value="ABB30417"/>
        <property type="gene ID" value="Gmet_0170"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0170"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_427413_0_0_7"/>
    <dbReference type="OMA" id="RASICHA"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223638" evidence="1">
        <location>
            <begin position="30"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="596" mass="66536" checksum="A1F7A72E022D7315" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZF8</accession>
    <name>Q39ZF8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Hydrogenase maturation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypD</name>
        <name evidence="4" type="ordered locus">Gmet_0117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the HypD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514122.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0117"/>
    <dbReference type="EnsemblBacteria" id="ABB30366">
        <property type="protein sequence ID" value="ABB30366"/>
        <property type="gene ID" value="Gmet_0117"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0117"/>
    <dbReference type="eggNOG" id="COG0409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048562_1_0_7"/>
    <dbReference type="OMA" id="HVCGSHE"/>
    <dbReference type="OrthoDB" id="666873at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11740">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002780">
        <property type="entry name" value="Hyd_form_HypD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042243">
        <property type="entry name" value="HypD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042244">
        <property type="entry name" value="HypD_2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30149">
        <property type="entry name" value="PTHR30149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01924">
        <property type="entry name" value="HypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005622">
        <property type="entry name" value="Hydrgn_mat_hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00075">
        <property type="entry name" value="hypD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="363" mass="39142" checksum="BDA0F78D7777B208" modified="2005-11-22" version="1">MKYQDEFRDRHVVLGLAARIREHVAGRTEPMTFMEVCGTHTMSIYQYGLRTLLPPQVRLISGPGCPVCVTPNEYLDRAVALCRLPDVIVATFGDMVRVPGSTSSLQEERARGADIRIVYSPLDAVAIAARNPEKRVVFLGVGFETTAPAIGGSILAAKKQGLANYFVLAAHKTMPKPMGVLSADPELKIDGYICPAHVSTITGPEIYRFLAEEFHIPCVITGFEPADVMQGVEMLVRQVVAGESRVETQYSRVVRPEGNRKAQEVIREVFTPCDAPWRGIGVIPGSGLRIADAYAVFDAEKAIPVAVEETREHAGCLCGEILKGKAAPTDCPLFGGACTPESPVGACMVSSEGTCAAAYKYGQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZK2</accession>
    <name>GATB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit B</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatB</name>
        <name type="ordered locus">Gmet_0073</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatB/GatE family. GatB subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514197.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZK2"/>
    <dbReference type="SMR" id="Q39ZK2"/>
    <dbReference type="STRING" id="269799.Gmet_0073"/>
    <dbReference type="EnsemblBacteria" id="ABB30322">
        <property type="protein sequence ID" value="ABB30322"/>
        <property type="gene ID" value="Gmet_0073"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0073"/>
    <dbReference type="eggNOG" id="COG0064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019240_0_0_7"/>
    <dbReference type="OMA" id="ARKWWMG"/>
    <dbReference type="OrthoDB" id="497127at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00121">
        <property type="entry name" value="GatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004413">
        <property type="entry name" value="Apn/Gln-ADT_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017959">
        <property type="entry name" value="Asn/Gln-tRNA_amidoTrfase_suB/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006075">
        <property type="entry name" value="Asn/Gln-tRNA_Trfase_suB/E_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018027">
        <property type="entry name" value="Asn/Gln_amidotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042114">
        <property type="entry name" value="GatB_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017958">
        <property type="entry name" value="Gln-tRNA_amidoTrfase_suB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11659">
        <property type="entry name" value="PTHR11659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02934">
        <property type="entry name" value="GatB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02637">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00845">
        <property type="entry name" value="GatB_Yqey"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00133">
        <property type="entry name" value="gatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01234">
        <property type="entry name" value="GATB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000241227" description="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B">
        <location>
            <begin position="1"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00121"/>
        </source>
    </evidence>
    <sequence length="479" mass="52508" checksum="5B68B62DD3E7747B" modified="2005-11-22" version="1">MNYQAVIGLEVHVQLKTDTKIFCGCSTQFGASPNSQTCPVCLGMPGALPVLNRKVVEFAIKAGLATNCRIAPRSVFARKNYFYPDLPKGYQISQFELPICQNGHLDIEVEGETKRIGITRIHMEEDAGKLVHSDIPGLGSGSGVDLNRACTPLLEIVSEPDIRSADEAVAYLKKLHQIVVYLGICDGNMEEGSFRCDANVSVMPVGSTTFGTRTETKNVNSFRFVKQAIEYEIERQIELIEEGGKVVQETRLFNPDSGETRSMRGKEEAHDYRYFPDPDLVPLVISNDWVADVALSLPELPEARRNRYRSDLGLSDYDAEVLTATREMAEYFEACLAAGAPAKGAANWVMGEVTRSLNEAGTGIADCPVTPERLTALLQLIEKGTISGKIAKTVFDEMWTNDKAPEAIVEEKGLVQVSDTGAIEKIIDEIMAANMGQVEEFRGGKEKVFGFFVGQVMRASKGKANPAVVNELLLKKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZQ9</accession>
    <name>Q39ZQ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513780.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0015"/>
    <dbReference type="EnsemblBacteria" id="ABB30265">
        <property type="protein sequence ID" value="ABB30265"/>
        <property type="gene ID" value="Gmet_0015"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0015"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_0_7"/>
    <dbReference type="OMA" id="GWGRQFF"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="4"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="356" mass="40414" checksum="546CC197AA6EA2D2" modified="2005-11-22" version="1">MAEEFIPKWVAWETTQKCNLKCVHCRCSSDLTSSEGDFTTEEGKKLLKEIADFSKPVIVLSGGEPLMRKDIFELAEYGTSLGLRMCMATNGALVTDEICQKMRKADIKMVSLSLDGSTAAVHDDFRQCPGAFEGVVRAAEIFRRNGQKFLINSSFTKRNQHDIANTFKLAKSLGATAWYMFMIVPTGRGEEIMNELITKEDYEEILEWHYQQEKLEDEILMRPTCAPHYYRMVPMRAKEEGVKFERRSLTFSTGGGKGCIAAQTICLIDCFGNVKPCSYFHRTAGNVKETPFREIWENSEIFKDLRNFKAYKGKCGECEFLNVCGGCRARADAVHGDYMAEEPFCNYVPIRLQKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYD4</accession>
    <name>J7LYD4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3588"/>
    <dbReference type="EnsemblBacteria" id="AFR42803">
        <property type="protein sequence ID" value="AFR42803"/>
        <property type="gene ID" value="Gmet_3588"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3588"/>
    <dbReference type="HOGENOM" id="CLU_214865_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003795600" evidence="2">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFR42803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="51" mass="4492" checksum="5FED3F1252FC2288" modified="2012-10-31" version="1">MMNGKWLVMIGMVAMTCALLAGCGGGGSGSGGGGGGGGGGVTTGTVTGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="18" xmlns="http://uniprot.org/uniprot">
    <accession>J7M0B2</accession>
    <name>J7M0B2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3624</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3624"/>
    <dbReference type="EnsemblBacteria" id="AFR42842">
        <property type="protein sequence ID" value="AFR42842"/>
        <property type="gene ID" value="Gmet_3624"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3624"/>
    <dbReference type="HOGENOM" id="CLU_2616963_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="78" mass="8124" checksum="1FF279275CCE0552" modified="2012-10-31" version="1">MTVSGEGFVRNRGAVKKRVSAGIPGVGLADGVFQTLDAVAGVRRVLVGASRRFSAEVGIVVAVVVVTQEIRRDTDSRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PQ5</accession>
    <name>RL34_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L34</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmH</name>
        <name type="ordered locus">Gmet_3564</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL34 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513719.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39PQ5"/>
    <dbReference type="SMR" id="Q39PQ5"/>
    <dbReference type="STRING" id="269799.Gmet_3564"/>
    <dbReference type="EnsemblBacteria" id="ABB33769">
        <property type="protein sequence ID" value="ABB33769"/>
        <property type="gene ID" value="Gmet_3564"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3564"/>
    <dbReference type="eggNOG" id="COG0230">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129938_2_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00391">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000271">
        <property type="entry name" value="Ribosomal_L34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020939">
        <property type="entry name" value="Ribosomal_L34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14503">
        <property type="entry name" value="PTHR14503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00468">
        <property type="entry name" value="Ribosomal_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01030">
        <property type="entry name" value="rpmH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00784">
        <property type="entry name" value="RIBOSOMAL_L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000013344" description="50S ribosomal protein L34">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00391"/>
        </source>
    </evidence>
    <sequence length="49" mass="5767" checksum="7A37FAEDA7E0D901" modified="2005-11-22" version="1">MKRTFQPSNTSRKRTHGFRVRMSTKNGRLVIKRRRARGRKRLAVTIAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PZ2</accession>
    <name>Q39PZ2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33682.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513924.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3474"/>
    <dbReference type="EnsemblBacteria" id="ABB33682">
        <property type="protein sequence ID" value="ABB33682"/>
        <property type="gene ID" value="Gmet_3474"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3474"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_7"/>
    <dbReference type="OMA" id="AKMAMHE"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="195"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33682.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="439" mass="46935" checksum="B93C6C092DCC3198" modified="2012-10-31" version="2">MKNQHTSNVSAKRLNYVVGEERLLRDVITETEVIPLLRGAVRAGARAAALADAEGTTLWSHAAPTDGGEAASLGLRGPAILLEGEPVGSILVKGERGREEFLKGIAVMLTAAVNLLVGSNLKRMLTTEIHTTVVNQSYEELLETNRKLTASEARYRELAESLEIKVEERTAELKKALARLLQQEKLASVGQLAAGIAHEINNPMGFVTSNIRTMQKYAGRFVEMLQFARDLFPVAGGGAGGERFAEKWRQLKLDMVLADVDELVSQSLGGAERVKKIVADLKGFSHIDDLGETVADLNAEIDRTLAVLVHEIPAGTEIAREYGSIPGLSCRAGELCQVFLNIIMNACQARSEGLRLTIRTALEGDAIAITITDNGPGILPELLDRVFEPFFTTKPVGQGMGMGLAVAHEVVTAHGGTVEAGSTPEGGASFVVRLPVTGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QB0</accession>
    <name>NUOD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit D</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoD</name>
        <name type="ordered locus">Gmet_3352</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512578.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QB0"/>
    <dbReference type="SMR" id="Q39QB0"/>
    <dbReference type="STRING" id="269799.Gmet_3352"/>
    <dbReference type="EnsemblBacteria" id="ABB33564">
        <property type="protein sequence ID" value="ABB33564"/>
        <property type="gene ID" value="Gmet_3352"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3352"/>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_1_2_7"/>
    <dbReference type="OMA" id="IMGTSME"/>
    <dbReference type="OrthoDB" id="473681at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000357823" description="NADH-quinone oxidoreductase subunit D">
        <location>
            <begin position="1"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01358"/>
        </source>
    </evidence>
    <sequence length="390" mass="43714" checksum="BE7FF0CDD4DABA1A" modified="2005-11-22" version="1">MASTEIMTVNMGPQHPSTHGVLRLVVELDGEIIQKITPHIGYLHRGVEKLSEHRTYHQTIPLTDRLDYLAPMHNNLGYVLAVEKLLGIEVPERAQTIRVILAELTRLKSHLVWVACHALDIGAMTVFIYAFREREMVMSLYEKISGARMTSSYFRVGGLSSDVYDGFEKDVREIVDTFPGHFDTYEGLLTKNTIWLNRTVGNGVISAEDAIDYGITGPALRGSGVDWDLRRDNPYSGYEKYQFKVPVGEKCDTFDRYKVRLVEMREAVNIIRQALDSLKPGPVLADAPQVTYPPKENVYNTIEGLIHHFKIASEGFPVPEGEVYQGVENPKGELGYYIVSDGGNKPYRMRIRPPSFVNLGAIEKMAKGSMIADLVAVIGTLDIVLGEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QD5</accession>
    <name>Q39QD5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512550.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3326"/>
    <dbReference type="EnsemblBacteria" id="ABB33539">
        <property type="protein sequence ID" value="ABB33539"/>
        <property type="gene ID" value="Gmet_3326"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3326"/>
    <dbReference type="eggNOG" id="ENOG50346VX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1309163_0_0_7"/>
    <dbReference type="OMA" id="GWEYASW"/>
    <dbReference type="OrthoDB" id="1788467at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223144" evidence="1">
        <location>
            <begin position="23"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="196" mass="21390" checksum="A2A2620DC0B50571" modified="2005-11-22" version="1">MAFIRTIVPVICVALFVAVSGAAPPPRPDTGIGVLLVGAVPGEPAPPQLILYGEPGIGRIAEKSAASLPHLAIPHKIPPGEFPLVVTARKGGWLKVIYDDAGRAAWLKPRRAWPFVLWDELLKGREARLLRGLKKPLYLLWGSGGDTVPDLEPLTPERSFRIISVDGDRIQVLLDLAVVGWLRWRDEDGRLLIALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QG1</accession>
    <name>Q39QG1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">etfB-9</name>
        <name evidence="4" type="ordered locus">Gmet_3300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512524.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3300"/>
    <dbReference type="EnsemblBacteria" id="ABB33513">
        <property type="protein sequence ID" value="ABB33513"/>
        <property type="gene ID" value="Gmet_3300"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3300"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_1_0_7"/>
    <dbReference type="OMA" id="LEYSCAT"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="258" mass="28290" checksum="B32B461BEA608236" modified="2005-11-22" version="1">MKILVCIKQVPDMESRFRVSSSGNWLEESDLAFRLNEYDEYAVEQAVQLKEQLGDIPEITVLSIGPDRVGESIRKALAMGCDRGVHIRDPESSRKDPWQIASLIASFAGDKEFDLILTGMQSQDRGSAQVGIMVSEILGYPCASTLVGFSYDNGIISARRELEGGTKAVVRLRTPAVVTCQLGLNVPRYPTLPNIMKAKKKEILSVPVADFSVVDGHATTLRLYQPAKKGGGLVIEGEVNDLADRLVGILKQKTMVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QG5</accession>
    <name>Q39QG5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA--acetate/3-oxoacid coenzyme A transferase, subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">atoD</name>
        <name evidence="3" type="ordered locus">Gmet_3296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-oxoacid CoA-transferase subunit A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512520.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3296"/>
    <dbReference type="EnsemblBacteria" id="ABB33509">
        <property type="protein sequence ID" value="ABB33509"/>
        <property type="gene ID" value="Gmet_3296"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3296"/>
    <dbReference type="eggNOG" id="COG1788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019942_2_0_7"/>
    <dbReference type="OMA" id="FVKAWKG"/>
    <dbReference type="OrthoDB" id="1660857at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004163">
        <property type="entry name" value="CoA_transf_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="PTHR13707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01273">
        <property type="entry name" value="COA_TRANSF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="229" mass="25077" checksum="56C463C8CC8B0222" modified="2005-11-22" version="1">MKVQSSIEKALEGIQDGATLMVGGFGLVGIPEKLILGLREKGVKNLTVISNNCGVDDFGLGILLQNRQIRKMVSSYVGENKEFERQFLSGELEVELTPQGTLAERIRAGGAGIPAFYTPAGVGTPLAEGREVRSFNGREYLLETGLVADFALVKAWKGDWMGNLIYNKTSRNFNPMMATAAKVTIAEVEDLLDPGELDPAFIHTPGVYVQRIVLCGNYEKRIERRTVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QK7</accession>
    <name>Q39QK7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane channel OmpJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ompJ</name>
        <name evidence="2" type="ordered locus">Gmet_3254</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512692.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3254"/>
    <dbReference type="EnsemblBacteria" id="ABB33467">
        <property type="protein sequence ID" value="ABB33467"/>
        <property type="gene ID" value="Gmet_3254"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3254"/>
    <dbReference type="eggNOG" id="ENOG502ZBFZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045956_0_0_7"/>
    <dbReference type="OMA" id="MILARNT"/>
    <dbReference type="OrthoDB" id="1022457at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004222988" evidence="1">
        <location>
            <begin position="25"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="472" mass="50846" checksum="1C2CB344377D47A2" modified="2005-11-22" version="1">MKKKVLAVSAACALTAATAVPALALENEFHGMFRVFGTMSNFNDGGSGRLLPTDATTGRDPKTRSFVEQRARLMYIAKANDDLKLVTHFEIDSRWGDNSYANGRNSGGAIGADTVNLETKNVYLDFNIPSTPMNFKVGIQPLVDSYKGVFFNTDVAAALATAKLGNGSVVVGFARLDDADTFTLGSAAGRSTSTPGKAKRDLYIVDGKYNITKDVKVGASYYLLNVDQKAGDNFVPTSTTQTYDYMRHTFGVNAEAKFAPLTLDGFLLYQTARTNGPDKIDQKGWAANLTGKGKLGPGTLKASFLYASGDSKRGTVRDDNTYYGITNETSGANGEHSFYESDMMILFRNKYNITGDRAIVYNVTNVIGGFVGYNANITPKAFANVNAGFVAAATGNDDFGSARVTIGGHKSDYLGTEINGEIGYKVFDNLTASLQGAYVFLGDYYKDTVGTAANPQTPRDPYEGRIMLNYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QK9</accession>
    <name>Q39QK9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">PDDEXK_3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33465.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512690.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3252"/>
    <dbReference type="EnsemblBacteria" id="ABB33465">
        <property type="protein sequence ID" value="ABB33465"/>
        <property type="gene ID" value="Gmet_3252"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3252"/>
    <dbReference type="eggNOG" id="COG0614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134960_1_0_7"/>
    <dbReference type="OMA" id="KIAPVHK"/>
    <dbReference type="OrthoDB" id="1879806at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026350">
        <property type="entry name" value="GxxExxY"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13366">
        <property type="entry name" value="PDDEXK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04256">
        <property type="entry name" value="GxxExxY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33465.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="136" mass="15455" checksum="F4C9F4CF3BB28613" modified="2012-10-31" version="2">MGITRRDGETEKKLLESELTDLIIGKAIVVHSTLGPGLLESVYEACLAYELSEAGLHVERQKVLPVRYKNINLDDGLRMDLVVENRIILELKCVDTILPVHEAQLQTYLKLSGLRVGLLMNFYTKYLKEGIKRIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QL2</accession>
    <name>Q39QL2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Biotin-dependent acyl-CoA carboxylase, biotin carboxylase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_3249</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512687.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3249"/>
    <dbReference type="EnsemblBacteria" id="ABB33462">
        <property type="protein sequence ID" value="ABB33462"/>
        <property type="gene ID" value="Gmet_3249"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3249"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_306483_0_0_7"/>
    <dbReference type="OMA" id="FHYGLVN"/>
    <dbReference type="OrthoDB" id="29058at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="8">
        <location>
            <begin position="31"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="7">
        <location>
            <begin position="228"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="959" mass="106868" checksum="CD90F338DBC351BA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QS9</accession>
    <name>Q39QS9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Poly(A) polymerase I</fullName>
            <shortName evidence="5">PAP I</shortName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">pcnB</name>
        <name evidence="11" type="ordered locus">Gmet_3182</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + RNA(n) = diphosphate + RNA(n)-3'-adenine ribonucleotide</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513899.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3182"/>
    <dbReference type="EnsemblBacteria" id="ABB33395">
        <property type="protein sequence ID" value="ABB33395"/>
        <property type="gene ID" value="Gmet_3182"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3182"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_0_0_7"/>
    <dbReference type="OMA" id="FMAKLDM"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004652">
        <property type="term" value="F:polynucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006378">
        <property type="term" value="P:mRNA polyadenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00957">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010206">
        <property type="entry name" value="PolA_pol_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025866">
        <property type="entry name" value="PolyA_pol_arg_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12626">
        <property type="entry name" value="PolyA_pol_arg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01942">
        <property type="entry name" value="pcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="8">
        <location>
            <begin position="42"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="10">
        <location>
            <begin position="219"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_arg_C" evidence="9">
        <location>
            <begin position="336"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="429"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="457" mass="50894" checksum="E07DCAE13D6E237F" modified="2005-11-22" version="1">MKTPMNSEPVIIPRPDHPISRSQVSPNALRVLYRLKDNGCIAYLVGGCVRDLLLGREPKDFDVATNATPNQVKRLFRNCRLVGRRFRLAHIHYQDEIIEVATFRALAPEEPEDTAPAPVSPENVPGEGERPRLPRHVVSDEGMVLRDNVFGTPEEDAVRRDFTVNALAYNIADFSIIDYANGMEDLRRGVIRTIGDPLVRFTEDPVRMLRAVRFAATLGFTVEDATWQAIRELAPAITRATAPRLYEEVLKLFLSGEGERVYQLLRQAGLFSHLFPRFSAWLDREIDGFPHSQVGKALEWADDQVGGGEPVSPPLLLALMFGEYVEERAAELADAGMPVPDAVNAAMAGFLGEQAPIIAIPQRIALAVREILLIQHRLRKIPGKRPQGVLARSCFAEALAYLRCRCAVTGEGGKILAWWERYARESVMPPVEPATGGGEAPPKRRRRRGKRRKPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QU9</accession>
    <name>Q39QU9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Outer membrane surface lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_3162</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513878.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3162"/>
    <dbReference type="EnsemblBacteria" id="ABB33375">
        <property type="protein sequence ID" value="ABB33375"/>
        <property type="gene ID" value="Gmet_3162"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3162"/>
    <dbReference type="eggNOG" id="COG0729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613645_0_0_7"/>
    <dbReference type="OMA" id="IRLFRWE"/>
    <dbReference type="OrthoDB" id="364966at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071709">
        <property type="term" value="P:membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Omp85" evidence="5">
        <location>
            <begin position="110"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="414" mass="46328" checksum="8026F221A6C9AFEC" modified="2005-11-22" version="1">MQRIVLLLFILGTSLLAACTTMVPREKLPYPITDASFGDPVKVVTIPLPVIATSPNEGAILGGLTAFLLHNARDEVNTLIAPQVNYNANFGTTFSLYGAFFPLPNRNWEFNLSTSTKVNEDYEVRLRDKTFLDGKLETNAFIYNFTDGSARFFGFQSDSRKEDETNYADKEYGFTLGVGYDIIDHLQLVVGERFRQVSIRRGAVSKLPSIRDRFTDSQVPGINGFTAHAQKLSLIYNTLDSRDMPTRGLYAKAAIEGSAEFLGSDASYRHYEAELKGYFPLKEARYITVARVAYNQTLGSDVPFLERSILGGESTLRGYGRNRFIDSSYFLCNLEERIRLFRWSVFDVNTDWEVAPFIDLGAVMESLDKTRSKNFEFNPGIGFRAVVRPNIVGRVDIGVGNDGPAVFVGLGYPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RA3</accession>
    <name>Q39RA3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integron integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_3006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514318.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3006"/>
    <dbReference type="EnsemblBacteria" id="ABB33221">
        <property type="protein sequence ID" value="ABB33221"/>
        <property type="gene ID" value="Gmet_3006"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3006"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_37_0_7"/>
    <dbReference type="OMA" id="VNCHTFR"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011946">
        <property type="entry name" value="Integrase_integron-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13495">
        <property type="entry name" value="Phage_int_SAM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02249">
        <property type="entry name" value="integrase_gron"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="6">
        <location>
            <begin position="15"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="5">
        <location>
            <begin position="116"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="334" mass="37936" checksum="53A9158A5193AAA6" modified="2005-11-22" version="1">MHPINMGKNASAVEPEKPRLLDILRTRIRLKHYSLRTEQTYTEWAKRYILFHGKRHPAEMGKEEVEAFLSHLAVKHNVSASTQSQARAAILFLYREVLDIELPWLDDVEQAKKPQRLPVVLTVSEVQALLSRLTGTHALMGRLMYGTGMRLMETVRLRVKDVDFERSEIIVREGKGAKDRITMLPQAVAAPLREHLGRVEALHGADLRAGFGEVHLPHALGKKYPNAGREWGWQYVFPAKQLSTDPRTGVTRRHHADEKGIQRAIRQAVRDAELAKPATPHTLRHSFATHLLQSGYDIRTVQELLGHKDVQTTMIYTHVLNRGGKGVESPLDRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RE2</accession>
    <name>Q39RE2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2967</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366129.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2967"/>
    <dbReference type="EnsemblBacteria" id="ABB33182">
        <property type="protein sequence ID" value="ABB33182"/>
        <property type="gene ID" value="Gmet_2967"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2967"/>
    <dbReference type="eggNOG" id="COG3012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050219_0_0_7"/>
    <dbReference type="OMA" id="ENCWASS"/>
    <dbReference type="OrthoDB" id="1637108at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="456" mass="51727" checksum="95409FB9FFE06593" modified="2005-11-22" version="1">MKTFFMQLQVVPTRENENYDMAEGALVGCWILETDPEVAFAKATFQVSKYDWLITGVETPPIEVTQENFVGEDIGAEQYAKAQQEGLAFFYVGWARDKKTSVEPITIRPSFKPNVESHLRKQKQEKNRGRCLHYDGGVRCREYINAHSIQKNQALSAISRDGHVYTPSANMTTLRENRGAPAYELNGIGTVSTFLGFCKKHDNELFAPIDNSLLLPTNEQVFLYAYRSICREVFVKDNALNLITHKINDIPANNFLRGHLEAFKAGTEIGFKNLKRHKSNYDDSLRKSAFNDIKHALFTFKGAPPIAFSGLFYPDYDFKGTQLQYLADHRNDFDLITFCSAPMAKGWGFLFAWHHTSSQICNRFLSSLFEEMSTGSRVADMLFRLVISACENHAISPIWWEQLPKDHKEEISRTFGCTVSSFSPTKATYLAKGLEGIAEWDLSSVITNTDLAPNLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RF0</accession>
    <name>Q39RF0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2957</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512892.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2957"/>
    <dbReference type="DNASU" id="3740812"/>
    <dbReference type="EnsemblBacteria" id="ABB33174">
        <property type="protein sequence ID" value="ABB33174"/>
        <property type="gene ID" value="Gmet_2957"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2957"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102893_0_0_7"/>
    <dbReference type="OMA" id="RCRDTFS"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="234" mass="25794" checksum="9A7C1A921202FB93" modified="2005-11-22" version="1">MWQQLMAEVRDQQALFDVAVREWVAGYALKQGTILCGKGCHACCSLAVNCTFTEALAVSTVLADRHAAALAEHAAAIRAAAFSSSDFPSFLRARRALGDCPFLDNDGACGVYGRRPFSCRSLLATRESHWCGADFSILSREEKRAFMESLDQTVVAFPMHYVKATQDLGQEFEERSAGRMIETFGFSLYGNLPALVFLEREHRLSEAAAKGRDAVQELVERAGYGHPFLVSFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RJ2</accession>
    <name>Q39RJ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512850.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2914"/>
    <dbReference type="EnsemblBacteria" id="ABB33132">
        <property type="protein sequence ID" value="ABB33132"/>
        <property type="gene ID" value="Gmet_2914"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2914"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1903696_0_0_7"/>
    <dbReference type="OMA" id="HQAVECA"/>
    <dbReference type="OrthoDB" id="1613954at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="14466" checksum="CA217D90BD975289" modified="2005-11-22" version="1">MEELLIAEKDPATRQQMAEHFIKEGYSVTVTDSLPNTLSNILKKVTRVVLLGAKFDELPTFDLIDLMKKCNQKLAIILVSDELPLPLLRKVRSSGIFYHALKPSGPEDVEEICQAVRCAFGNGMKGHAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RS3</accession>
    <name>Q39RS3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2833</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513970.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2833"/>
    <dbReference type="EnsemblBacteria" id="ABB33051">
        <property type="protein sequence ID" value="ABB33051"/>
        <property type="gene ID" value="Gmet_2833"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2833"/>
    <dbReference type="eggNOG" id="ENOG50331N7">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080981_0_0_7"/>
    <dbReference type="OMA" id="RRSCGRN"/>
    <dbReference type="OrthoDB" id="1721190at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024523">
        <property type="entry name" value="DUF3793"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12672">
        <property type="entry name" value="DUF3793"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="224" mass="24098" checksum="3D6F1E1960620DAB" modified="2005-11-22" version="1">MDEIQPVRQEGGKRPAWHELAVRFADPRECLASFLALEAAAVLAGEKPANLIGIANRSRPCGRNLYTLWKQWGASVLPESGLAVCELVDRGDSLLLLIYRSEALGGLLGRPSTSAVLGRAGYADLSDLDAVLGELAARITGESFPHEIGVFLGYPLKDVVAFMGLVTIPFACQGPWKIFGDPRESLRLAEVFRSCRARMAERLGSCASALECLVGGEQRVAVAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RT1</accession>
    <name>Q39RT1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Methyl-accepting chemotaxis sensory transducer, class 40H, Cache_2 domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mcp40H-11</name>
        <name evidence="11" type="ordered locus">Gmet_2825</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513979.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2825"/>
    <dbReference type="EnsemblBacteria" id="ABB33043">
        <property type="protein sequence ID" value="ABB33043"/>
        <property type="gene ID" value="Gmet_2825"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2825"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_21_7"/>
    <dbReference type="OMA" id="YLWINDL"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004010">
        <property type="entry name" value="Double_Cache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033480">
        <property type="entry name" value="sCache_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08269">
        <property type="entry name" value="dCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01049">
        <property type="entry name" value="Cache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="239"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="9">
        <location>
            <begin position="298"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="570" mass="62217" checksum="D86CEC1B3DB17F13" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RT2</accession>
    <name>Q39RT2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Gmet_2824</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513980.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2824"/>
    <dbReference type="EnsemblBacteria" id="ABB33042">
        <property type="protein sequence ID" value="ABB33042"/>
        <property type="gene ID" value="Gmet_2824"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2824"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_21_7"/>
    <dbReference type="OMA" id="FENTEMA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="338"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="402"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="637"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="10">
        <location>
            <begin position="885"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="863"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB33042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1018" mass="112639" checksum="7D74DFC73CAB0708" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RZ5</accession>
    <name>Q39RZ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Periplasmic substrate-binding sensor protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511700.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2761"/>
    <dbReference type="EnsemblBacteria" id="ABB32979">
        <property type="protein sequence ID" value="ABB32979"/>
        <property type="gene ID" value="Gmet_2761"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2761"/>
    <dbReference type="eggNOG" id="COG3452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_62_7"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="6">
        <location>
            <begin position="102"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="289"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="406" mass="45076" checksum="6FA01F77CE58088D" modified="2005-11-22" version="1">MKHGGPIRGAILLFALFLGAGSVFVRQVEEGRCREQRRNVAQLAAGAAFSLERQISGSLSATYALAAILRQAGTIKDFDALAAEMIRTYGGISSLQLAPAGVMTTIYPLAGNEKAIGHDLLSDPLRRTEAQRAIESRQMTLAGPFELRQGGVGAVGRLAVFLPEPGRGERFWGFVNVLMRLRDLLAASNLEALDKGGYGYELTRLNPDTGRWESIARSDGPLQAPVESTIDVPNGTWKLAVAPKQGWQTSPFLYVEYLMVGGISGILALLAYLMLRQPEKLRHEVLLRTADLEKANRQLEAQIRERQRAEDELRRLNADLELRVTERTVQLENSNRELESFSYSVSHDLRAPLRHMESFSRILAEDHAGQIGEGGEQCLERIVAEIQRMKLHIDSLLEQAQVERIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S17</accession>
    <name>Q39S17_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response receiver scaffold protein CheV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cheV</name>
        <name evidence="4" type="ordered locus">Gmet_2739</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511720.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2739"/>
    <dbReference type="EnsemblBacteria" id="ABB32957">
        <property type="protein sequence ID" value="ABB32957"/>
        <property type="gene ID" value="Gmet_2739"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2739"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_0_1_7"/>
    <dbReference type="OMA" id="TEIRNDP"/>
    <dbReference type="OrthoDB" id="1687028at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024181">
        <property type="entry name" value="Chemotax_regulator_CheV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002867">
        <property type="entry name" value="CheV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="3">
        <location>
            <begin position="14"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="183"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="312" mass="34937" checksum="F24C1A919A956723" modified="2005-11-22" version="1">MADHTILLESGTNELEIVEFMLNEHNEKGEAIPSYFGVNVAKVREIIRKPQMWKVPNAHPAIAGMMKLRDKVITVVDLATTLGKNMSCLAPDRVIVLEFNRMMIGVLVNGVSRIYRISWEQVEPPVRAIESAYVTGMVKMEDRIILILDFEKIVGEICCMDVLHEIGHDQLLEGAILDRSRHRILVADDSTFIRNSICSSLRAAGYNVEEAENGEDAWNMIVAKLSHCRAAGTPLRSELDLLITDVEMPKMDGLHLTSLVKKDDVLKELPVLIFSSLATEDNRRKWKDLGALDIVTKPDLPNLVKIADGVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S26</accession>
    <name>Q39S26_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511730.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2730"/>
    <dbReference type="EnsemblBacteria" id="ABB32948">
        <property type="protein sequence ID" value="ABB32948"/>
        <property type="gene ID" value="Gmet_2730"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2730"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645348_0_0_7"/>
    <dbReference type="OMA" id="ISFGQGC"/>
    <dbReference type="OrthoDB" id="259346at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="188"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="441" mass="50281" checksum="867B16F8FB959D2B" modified="2005-11-22" version="1">MKRKTLPKLLYADAKGNIFDHPDLCMAGMSGPEAVLPEGVELIPLPEGSRLFTIPDTPPVAWDEKQRKFVTVPTVREGRRNLPVQAVSAFMAPGYVRTLLPACDYGRKKVHLPLWSYTAVGWDEERDCFVVAASRVDTNDNWNPNNYDDRKLDPLVRQRLAEMPNNRLLEQLARCAVDYHCFAAKNLFFRRWEAPLPTSPACNSRCLGCISLQPSDCCPSNHERIGFVPTPEEIVELALPHLEQAPEPIVSYGQGCEGDPIMQADTVAEATRRLKKATSRGIVNFNSNGSFLDRIAMLCDAGMDSMRFSMNSVREEFYDKYYRPVGYRFADVKESVRLAKERGLFVMINYLVSPGLSDNADEVEALLRFIGDTGLDMIQMRNLSIDPDFYNKRMGVTGRGIGMYRMLERVKREFPRIQYGYYNRTRENFYPEGLEKSWPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S32</accession>
    <name>Q39S32_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rep</name>
        <name evidence="9" type="ordered locus">Gmet_2724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511736.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2724"/>
    <dbReference type="EnsemblBacteria" id="ABB32942">
        <property type="protein sequence ID" value="ABB32942"/>
        <property type="gene ID" value="Gmet_2724"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2724"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004585_5_2_7"/>
    <dbReference type="OMA" id="VTLMSLH"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="7">
        <location>
            <begin position="5"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="8">
        <location>
            <begin position="286"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="678" mass="77850" checksum="4FE32CEA3F2EB2FB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S45</accession>
    <name>CHEB4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-glutamate methylesterase/protein-glutamine glutaminase 4</fullName>
            <ecNumber evidence="1">3.1.1.61</ecNumber>
            <ecNumber evidence="1">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cheB4</name>
        <name type="ordered locus">Gmet_2711</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="1"/>
    <dbReference type="EC" id="3.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511749.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39S45"/>
    <dbReference type="SMR" id="Q39S45"/>
    <dbReference type="STRING" id="269799.Gmet_2711"/>
    <dbReference type="EnsemblBacteria" id="ABB32929">
        <property type="protein sequence ID" value="ABB32929"/>
        <property type="gene ID" value="Gmet_2711"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2711"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_7"/>
    <dbReference type="OMA" id="RKFKFDV"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264279" description="Protein-glutamate methylesterase/protein-glutamine glutaminase 4">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="1">
        <location>
            <begin position="157"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <sequence length="347" mass="36897" checksum="3D4B2EDC2FC2E219" modified="2005-11-22" version="1">MVKVLIVDDSASVRLFLQGLLAADPGIEVIGTAADGDEAVEAVARLNPDVVTMDIYMPRMNGLLATRRIMETHPVPIVVVSGNLDAEEVASTFRAIEAGAVTALPRPQGPGHPNHEREARSFVQAVKLMAEVKVIKRWPRRDNPASLPSLPCQAMVPARLKAVAIGASTGGPMVLQTILAGLRRDFPLPVLIVQHMATGFIKGFVEWLNLTSALPVHIAGNGDRLIPGHAYVAPDCFHMLVTEDGTAIELQNTPPENGLRPSVSALFRSVTQAFGAQTVGVLLTGMGSDGARELKRLREAGAVTIVQDRESSVIHGMPGEALKLGAATHTLPPDRIVTALTSLAMEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S71</accession>
    <name>RLMN_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dual-specificity RNA methyltransferase RlmN</fullName>
            <ecNumber evidence="1">2.1.1.192</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (adenine(2503)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m2A2503 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA (adenine(37)-C(2))-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA m2A37 methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmN</name>
        <name type="ordered locus">Gmet_2685</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(2503) in 23S rRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(2503) in 23S rRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42916"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10282"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + 2 reduced [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine = 2-methyladenosine(37) in tRNA + 5'-deoxyadenosine + L-methionine + 2 oxidized [2Fe-2S]-[ferredoxin] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43332"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10485"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74497"/>
            <dbReference type="EC" id="2.1.1.192"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the radical SAM superfamily. RlmN family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.192" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511775.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39S71"/>
    <dbReference type="SMR" id="Q39S71"/>
    <dbReference type="STRING" id="269799.Gmet_2685"/>
    <dbReference type="EnsemblBacteria" id="ABB32903">
        <property type="protein sequence ID" value="ABB32903"/>
        <property type="gene ID" value="Gmet_2685"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2685"/>
    <dbReference type="eggNOG" id="COG0820">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029101_0_0_7"/>
    <dbReference type="OMA" id="QVGCSLD"/>
    <dbReference type="OrthoDB" id="1111428at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070040">
        <property type="term" value="F:rRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002935">
        <property type="term" value="F:tRNA (adenine-C2-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01849">
        <property type="entry name" value="RNA_methyltr_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027492">
        <property type="entry name" value="RNA_MTrfase_RlmN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004383">
        <property type="entry name" value="rRNA_lsu_MTrfase_RlmN/Cfr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="PTHR30544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006004">
        <property type="entry name" value="CHP00048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00275">
        <property type="entry name" value="adenosine_C2_methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00048">
        <property type="entry name" value="rRNA_mod_RlmN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000350194" description="Dual-specificity RNA methyltransferase RlmN">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="100"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="S-methylcysteine intermediate" evidence="1">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="159"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="213"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="(transient)" evidence="1">
        <location>
            <begin position="107"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="346" mass="38838" checksum="DDBD5061246D9D2C" modified="2005-11-22" version="1">MMNGKIDIKNLTLDDLIAFLAGKGKERYRARQIFKWLYQKDARSFAEMTDLAKDLRRDLEETAVISDLEPEAMEVSRDGTRKYLFRLEDGNTVESVLIPEEDRTTLCISSQVGCAMACEFCLTGTFRLTRNLTAGEIVNQICAVRRDVPVRNIVFMGMGEPLANLDNVVKALKIILHDDGLQFSTRRVTVSTSGLVPEMERLGREVTVNLAVSLNATTDEVRDRIMPVNRRYPLRLLLDACRSYPLPGRRKITIEYVMIKGLNDSLEDAKRLVKLLSDISSKINLIPFNEHDGCSFKSPDQGAIDVFHSYLLSKHFTVITRSSRGSDISAACGQLKGKLDKNVSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S75</accession>
    <name>Q39S75_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511779.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2681"/>
    <dbReference type="EnsemblBacteria" id="ABB32899">
        <property type="protein sequence ID" value="ABB32899"/>
        <property type="gene ID" value="Gmet_2681"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2681"/>
    <dbReference type="eggNOG" id="COG1426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047530_1_2_7"/>
    <dbReference type="OMA" id="ADCWTQV"/>
    <dbReference type="OrthoDB" id="2071222at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025194">
        <property type="entry name" value="DUF4115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13464">
        <property type="entry name" value="DUF4115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="280" mass="29777" checksum="DCCE0CDBC0AF5D3B" modified="2005-11-22" version="1">MSDALTPGKGGTSIGILLRETRESRGESREDAARVTRIGKNYLAALEEESFDKLPSPAYVKGFLRVYGKHLGLSPDDLVARYEEQLVPAPATEQEEDEGGAPPVARVAIPPIRNRWMIPLVLLALVLVTATIIPQREPAPVRPVPEPVPARVLLAPPPVQSPLSSVAAAPLSKLQEAPAESAEAASPEAAAPSTKPGGMVLKLKVNQDCWLDITIDGAVSQQYDLKAGDLIEWKGERVFSLDLGNAGGVEAEFNGKVLPSFGEAGKTAHVTLPAEYTAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SD1</accession>
    <name>Q39SD1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511836.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32843">
        <property type="protein sequence ID" value="ABB32843"/>
        <property type="gene ID" value="Gmet_2624"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2624"/>
    <dbReference type="eggNOG" id="ENOG5032VRQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660156_0_0_7"/>
    <dbReference type="OMA" id="NELEYDR"/>
    <dbReference type="OrthoDB" id="1456488at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223209" evidence="1">
        <location>
            <begin position="22"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="420" mass="47213" checksum="A63F711F63E24CAF" modified="2005-11-22" version="1">MCAVAACCALLSVLAPVTVLCAEEAEYHTPLAGEPLNGELWGHRFDIPARDRDYVRSFTLGGVFFSPKLGSDWGVPFGAFYRRKYEEPWRSRAVIGGFVNELDLARDFGHFQLLGHWDNNTVPFPTDEIIDGKEMKSTSIIYGSFNGGVGVGYRLPVAPFQSDNAFRLKLLYNAGYLYTGRVSDTGADVKLPPSTFVHGFKLSADYDSIRRNLMELPHEGWAGGIAVELGRRNHWRDHTFGGTVFRGDRTRDYLKVSAFFTGATGIPGLSERHRLIGILHGGFAPKDSIDRFSAFRIGGGPFPSETDDLYRYWYPGAMFNQFPASDFVIGSLEYRYELLFFLYLHLRGTIAEVNRPFLRQDSFNLSRLDFTHDYSGAFSLGLTSGLPWDSQLYLEYTYDTRILRNGVGGSSFLAQWSKSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SG4</accession>
    <name>Q39SG4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin, HicB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514790.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2591"/>
    <dbReference type="EnsemblBacteria" id="ABB32810">
        <property type="protein sequence ID" value="ABB32810"/>
        <property type="gene ID" value="Gmet_2591"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2591"/>
    <dbReference type="eggNOG" id="COG4226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134927_1_0_7"/>
    <dbReference type="OMA" id="AATEHHI"/>
    <dbReference type="OrthoDB" id="1924179at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008651">
        <property type="entry name" value="Uncharacterised_HicB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05534">
        <property type="entry name" value="HicB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="112" mass="12399" checksum="C0F20BCFD5AD412F" modified="2005-11-22" version="1">MNNMTINDYDAVISYDPEINMFRGEFVGINGGADFYASTVDDLRKEGEISLKAFLEMCAEEGVEPRKHFSGKFNLRVPPALHQRLAAQAAAHGKSINAWVVELLSECAVRGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SG5</accession>
    <name>Q39SG5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32809">
        <property type="protein sequence ID" value="ABB32809"/>
        <property type="gene ID" value="Gmet_2590"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2590"/>
    <dbReference type="eggNOG" id="ENOG5034A7N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1537904_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025522">
        <property type="entry name" value="DUF4410"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14366">
        <property type="entry name" value="DUF4410"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223063" evidence="1">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="174" mass="18788" checksum="DACB99B504F25B2C" modified="2005-11-22" version="1">MFAKVRNASMVFLCAMFLAACSSSGTFTMKQALIEPINNQKTVSIWVKSDKVPESEKEDAKKACSSLQEKLYARLVSEGLFKSSVIYPNKGDYSLEVDVLGVRLVSNTARLWLGVMAGASGIETNVLLRDETGKVLAEFNADGSSATHPMSSESGSDNAVNELATEIAQALKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SN3</accession>
    <name>Q39SN3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nitrite/sulfite reductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514531.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2520"/>
    <dbReference type="EnsemblBacteria" id="ABB32741">
        <property type="protein sequence ID" value="ABB32741"/>
        <property type="gene ID" value="Gmet_2520"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2520"/>
    <dbReference type="eggNOG" id="COG0155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015667_2_4_7"/>
    <dbReference type="OMA" id="RMHMSGC"/>
    <dbReference type="OrthoDB" id="1588103at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="110"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR_ferr" evidence="5">
        <location>
            <begin position="262"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="4">
        <location>
            <begin position="368"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="435" mass="46963" checksum="6297EC532D298746" modified="2005-11-22" version="1">MMFDPQSVRIDGVYEQRQPGNFMLRIKVPAGIISTEQALRVAEIADRFAGGSVHLTTRGSIELHWLKQENLAEAWRMLASVGLTTRGACGGAVRGVVCAMPGDAGYGAAQLLARRLLAHFTHNPRFEGLPKKFKIGVFTGYGDGRHLIQDLSVILREGADGNSSYDVWIAGGLGREPHASFLLEEGVAGERLIPLAEAIISLYRELTPKGKRLKHLVRERGREEFVKLVRERVAAIPPLSLGAGLATPLTSAPREGAAERLTAGIFAGELGTKRFVDLAEIARQYAGGYMVVTGEQNVLFILDDGALRDDAARALAAAGFGCDSPAERVCFRICPGNHECKMGLSPTRDVARELAGTLGEAGERLSWSICGCPNSCSHPQLADVGIATVKSVKDEQGERHPLFDLYRRYGTDGFGVVVRHGIGIDELLEAVREIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SP4</accession>
    <name>Q39SP4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MatE-like domain efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514778.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2508"/>
    <dbReference type="EnsemblBacteria" id="ABB32730">
        <property type="protein sequence ID" value="ABB32730"/>
        <property type="gene ID" value="Gmet_2508"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2508"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_0_1_7"/>
    <dbReference type="OMA" id="VGNWIGS"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="463" mass="49767" checksum="C671386D9CAB4965" modified="2005-11-22" version="1">MTSPDLINDPIPKLLTRLAVPVGTGFFFNTMFNVVDTFYGGLISTRALAALSLSFPLFFIVLAIGAGTSMGATALIGHALGSDQREEAELFAAQAISFGVIHALFMTVGGVAAAPALFRLMGASGDYLDLALAYMDVIIAGTVFFVGNYVLNAMLNASGDTKSFRNFLVAGCFLNMALDPWFMYGGVGVPALGIRGIALATVVVQAAGNVYLLGRVRRTGLLSGRSWQLLMPRREPFRRLFGQGIPASMNMLTVSLGMFVITWFAGRFGKEVVAAYGIGTRIEQIVLLPAFGLNVAVLSLVAQNFGAGKLRRIRETLTRALRAGLLMMAGGTTLVFAAAEPLMKLFTADPLVVAHGVTFLRVESLLLGAYVILYMNNSALQGLQRPAFALWIGLFRQIIVPVPIFWLLALVLGWGPPGIWWGFFLVTWSAAMVSVLYTRRVLRLATEEADAALMRNGNNGPPP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SQ9</accession>
    <name>TRPF_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
            <shortName evidence="1">PRAI</shortName>
            <ecNumber evidence="1">5.3.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpF</name>
        <name type="ordered locus">Gmet_2492</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TrpF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.24" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514654.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SQ9"/>
    <dbReference type="SMR" id="Q39SQ9"/>
    <dbReference type="STRING" id="269799.Gmet_2492"/>
    <dbReference type="PRIDE" id="Q39SQ9"/>
    <dbReference type="EnsemblBacteria" id="ABB32715">
        <property type="protein sequence ID" value="ABB32715"/>
        <property type="gene ID" value="Gmet_2492"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2492"/>
    <dbReference type="eggNOG" id="COG0135">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076364_2_0_7"/>
    <dbReference type="OMA" id="FYAKSPR"/>
    <dbReference type="OrthoDB" id="1854712at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00042"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044643">
        <property type="entry name" value="TrpF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42894">
        <property type="entry name" value="PTHR42894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_1000071439" description="N-(5'-phosphoribosyl)anthranilate isomerase">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00135"/>
        </source>
    </evidence>
    <sequence length="202" mass="21717" checksum="E0D5588C0DD5DBC4" modified="2005-11-22" version="1">MVRVKICGITSLEDALMAVEAGADALGFVFHEDSPRHVPPEQATGIIAGLPPFVQTVGLFVNRPIAYVNETAARCRIDLVQLHGDEPPEFCAAVERRVIKAFRVQDITSLDPIKHYRVAAHLLDAYSPKAYGGTGLTFNWDIAAAAKEFGPVILAGGLTPDNIREAVEAVNPYAVDVSGGVESAPGRKDAAKVREFIRRAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SU8</accession>
    <name>Q39SU8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccdA-1</name>
        <name evidence="3" type="ordered locus">Gmet_2451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512449.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2451"/>
    <dbReference type="EnsemblBacteria" id="ABB32676">
        <property type="protein sequence ID" value="ABB32676"/>
        <property type="gene ID" value="Gmet_2451"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2451"/>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053225_2_0_7"/>
    <dbReference type="OMA" id="TSLTPCM"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="11"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="242" mass="26523" checksum="BCF4084E1A6C3A23" modified="2005-11-22" version="1">MDSSHVTFLGAFIAGFLSFLSPCVLPLIPSFITYITGLSFSDLQAEHPSHKVRQQTIVHTLLFIAGFTTVFVLLGASATFIGGFLHEHMDIIRKVGGILIIIFGIHVTGLVPIHLLLGEKRVTVHRKPAGYLGSFVVGLAFAAGWTPCIGPILASILMVATTEETVSRGVLLLLTYSMGLAIPFFLSSLAMHQFLVVFNRFKKHIRIFEIITGVFLIIVGVMIFSNYLSILSRFSMKWLGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SX1</accession>
    <name>Q39SX1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver CheY associated with MCPs of class 34H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY34H-1</name>
        <name evidence="3" type="ordered locus">Gmet_2428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32653.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512472.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2428"/>
    <dbReference type="EnsemblBacteria" id="ABB32653">
        <property type="protein sequence ID" value="ABB32653"/>
        <property type="gene ID" value="Gmet_2428"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2428"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="MHFTKPF"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32653.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="121" mass="12834" checksum="7D8AE0E5478264A1" modified="2012-10-31" version="2">MAKTIMTVDDSASVRQMVAFTLKQNGYDVVEAVDGKDALGKLGGAKVDMVITDLNMPNLDGIGLIKGVRGLPAYRFTPIIMLTTESQDAKKAEGKAAGATGWIVKPFKPEQLVAVVKKVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SX6</accession>
    <name>Q39SX6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis sensory transducer, class 34H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mcp34H-3</name>
        <name evidence="7" type="ordered locus">Gmet_2423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366049.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2423"/>
    <dbReference type="EnsemblBacteria" id="ABB32648">
        <property type="protein sequence ID" value="ABB32648"/>
        <property type="gene ID" value="Gmet_2423"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2423"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_16_7"/>
    <dbReference type="OMA" id="MARRHDE"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="391"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="446"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="740" mass="80004" checksum="7E76CEBED8DF5568" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SX8</accession>
    <name>Q39SX8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Scaffold protein CheW associated with MCPs of class 34H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheW34H</name>
        <name evidence="2" type="ordered locus">Gmet_2421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32646.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512479.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2421"/>
    <dbReference type="EnsemblBacteria" id="ABB32646">
        <property type="protein sequence ID" value="ABB32646"/>
        <property type="gene ID" value="Gmet_2421"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2421"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_1_1_7"/>
    <dbReference type="OMA" id="DEEYGVE"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32646.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="164" mass="18028" checksum="D247B18484A4D23E" modified="2012-10-31" version="2">MSVAAITETRQYLTFKLAEEIFAVDVAKVREILEFTTITKVPQTPDFMRGVINLRGSVVPVMDMRLKFGMPVTEKTVNTCIIVVEVNHEGETIIIGALADSVQEVFELEPEQIEPAPRIGTKLNTDFILGMGKHDGQFIMILDIDRTFTSDEIATAGVVAGEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T15</accession>
    <name>Q39T15_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA (5-carboxymethylaminomethyl-2-seleno-U34)-2-selenouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">selU</name>
        <name evidence="3" type="ordered locus">Gmet_2384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514757.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2384"/>
    <dbReference type="EnsemblBacteria" id="ABB32609">
        <property type="protein sequence ID" value="ABB32609"/>
        <property type="gene ID" value="Gmet_2384"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2384"/>
    <dbReference type="eggNOG" id="COG2603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043456_0_0_7"/>
    <dbReference type="OMA" id="RPLVYCW"/>
    <dbReference type="OrthoDB" id="1052499at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043828">
        <property type="term" value="F:tRNA 2-selenouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017582">
        <property type="entry name" value="SelU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03167">
        <property type="entry name" value="tRNA_sel_U_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0711">Selenium</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="11"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="345" mass="39282" checksum="CC1FC629053F75F9" modified="2005-11-22" version="1">MTRTISFHESLLDTHLVVDARTPLEFEEDHIPGAINVPLLTDEERVEIGTLYKQTGPLEARRRGLELTAHRFPAMVEKIAAAAAGRPILVYCWRGGLRSKTITAILDLTGFDAVQLVGGYKAFRAMVTEYFESFHPPAPLVVLHGMTGVGKTTFLLQLAEAGHSVIDLEGLACHRGSAFGSLGLSQNLSQKRFETLLWDAFRKLPTDRPILLEGESKRIGRINLPGNLYDVMRESVKVWCNASVETRVERLIGEYGLPEYRQGMSEALERIRKKLGGEKFEEISGYLERWELDPFMEGLIRNYYDKLYYKTREWTEDAIVSLEDFTAGRRELEEFLDARQWRLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T55</accession>
    <name>Q39T55_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-glucose--lipopolysaccharide core heptose I 4-beta-glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513276.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2344"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32569">
        <property type="protein sequence ID" value="ABB32569"/>
        <property type="gene ID" value="Gmet_2344"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2344"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065962_1_0_7"/>
    <dbReference type="OMA" id="YTELWAL"/>
    <dbReference type="OrthoDB" id="1379602at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="249" mass="28939" checksum="B978D16CD9F61386" modified="2005-11-22" version="1">MNITATIIAKNEEKNISDCLASLDWADEIIVVDSGSSDRTPEICRKHPKVRYFEHEWEGFGKQKNFAADQAVNDWVFNIDADERVSPELRDSILSTDFARYDGFRVARENYFGRRWIKHCGWYPDHNLRLYNRSRCRFAERLVHESVECPGPVSTLQGNLIHFTYEGIGDYVARMDRYSTLAAEEIARSGRRPGVFSIVFRPCFTFFKMYVLRMGVLEGSTGLLLSLLYAVYTFLKYAKSVELIEERQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T70</accession>
    <name>Q39T70_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE-1</name>
        <name evidence="10" type="ordered locus">Gmet_2329</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32554.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513291.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2329"/>
    <dbReference type="EnsemblBacteria" id="ABB32554">
        <property type="protein sequence ID" value="ABB32554"/>
        <property type="gene ID" value="Gmet_2329"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2329"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_7"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32554.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="326" mass="35465" checksum="969C80E88E987F6E" modified="2012-10-31" version="2">MTVLVTGGAGYIGSHVVRQLSEAGYTVVVYDNLSTGFADALVHGERLVVGELADSDRLDALFAEHGFKTVLHFAASIVAPESVTDPLKYYSNNTRNTLNLLTACVKHGVERFIFSSTAAVYGMPENGIAAEESPTVPINPYGTSKLMSEWMLRDVCAAHGMRSVALRYFNVAGADPQARMGQRTPEATHLIKVSSQAALGMREKVSIFGTDYATPDGTGIRDYIHIEDLASAHLAALAYLERGGETTRINVGYGKGASVREVIEMVRRVSGVHFPAEEAPRRPGDPAMLVAKADRARTVLGWTPHYDDLETIVADAWRWEAKLNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T91</accession>
    <name>Q39T91_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver CheY associated with MCPs of class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY40H-2</name>
        <name evidence="3" type="ordered locus">Gmet_2308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513312.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2308"/>
    <dbReference type="EnsemblBacteria" id="ABB32533">
        <property type="protein sequence ID" value="ABB32533"/>
        <property type="gene ID" value="Gmet_2308"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2308"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="RSGFEIC"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="123" mass="13425" checksum="CCF71D5ABA468DFF" modified="2005-11-22" version="1">MTKKKILIVEDEESLLKLESILLTSRGYEVVGATDGVAALEQVGLTRPDLVILDIMLPEIDGFEVCRRIKQNPETAHTPVVMLTAKKSEQDCARGMAAGASAYVTKPFKSAKIIEIIQDLLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TE5</accession>
    <name>Q39TE5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2253"/>
    <dbReference type="EnsemblBacteria" id="ABB32479">
        <property type="protein sequence ID" value="ABB32479"/>
        <property type="gene ID" value="Gmet_2253"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2253"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_5_1_7"/>
    <dbReference type="OMA" id="CAELLGW"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="15937" checksum="390DD980F94C8D12" modified="2005-11-22" version="1">MENSALLTELERSFTEKNYQTWLGVRLVRHKPGFVHLELPVRPEFLNTLGTVHGGFLANLADSALCSAILSELPPGITCSSIEIKVNYLLPVRGNILRADASVIRRGKNIGVSRAELFAPDGALAAVATGTFMIQSLSSFSCLPRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TI3</accession>
    <name>Q39TI3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365970.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2214"/>
    <dbReference type="EnsemblBacteria" id="ABB32441">
        <property type="protein sequence ID" value="ABB32441"/>
        <property type="gene ID" value="Gmet_2214"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2214"/>
    <dbReference type="HOGENOM" id="CLU_2329192_0_0_7"/>
    <dbReference type="OrthoDB" id="2015374at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="104" mass="10885" checksum="030C80F50643DE8F" modified="2005-11-22" version="1">MGHFRVCVKYCGNCNPEVDTPGIVRKVQALAPDIEWVWGDCPSVDLVLVASGCSVACAASPLFTGPTVTLVCTTLNGRKLPEADLAAAILAEIRGSLGTVRKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TI8</accession>
    <name>Q39TI8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(R)-methylmalonyl-CoA mutase, catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365965.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2209"/>
    <dbReference type="EnsemblBacteria" id="ABB32436">
        <property type="protein sequence ID" value="ABB32436"/>
        <property type="gene ID" value="Gmet_2209"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2209"/>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_7"/>
    <dbReference type="OMA" id="NTARITM"/>
    <dbReference type="OrthoDB" id="720283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="1">
        <location>
            <begin position="34"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="556" mass="61825" checksum="02F1FAFCD80AABF9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TJ1</accession>
    <name>Q39TJ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2206</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365962.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2206"/>
    <dbReference type="EnsemblBacteria" id="ABB32433">
        <property type="protein sequence ID" value="ABB32433"/>
        <property type="gene ID" value="Gmet_2206"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2206"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_7"/>
    <dbReference type="OMA" id="QHGKIDN"/>
    <dbReference type="OrthoDB" id="1294334at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="254" mass="27091" checksum="947E78A091885BDC" modified="2005-11-22" version="1">MSLDIFNLEGKVAIVTGGSRGFGKAIALGLAQAGADVVVASRTQADLDAVAEEIRALGRKSLAVATDMLDRGSIENLAAKTMEAFGKIDILVNNAGQGWTVPFLKWTDEQWDQILDVNLKGYFLCTQIVGQHMFKAKAGRVINISSAMGSYPLPYMVPYAASKGGINAMTKCLAQEWATRGITVNAIAPSYFSTDINKDAMEDEATTKLIMSKTPVNRWGNVEELVGLVIYLSSNASSFMTGAVLPLDGGWSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TM7</accession>
    <name>Q39TM7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2168"/>
    <dbReference type="EnsemblBacteria" id="ABB32397">
        <property type="protein sequence ID" value="ABB32397"/>
        <property type="gene ID" value="Gmet_2168"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2168"/>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_509724_0_0_7"/>
    <dbReference type="OrthoDB" id="1584918at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223278" evidence="5">
        <location>
            <begin position="30"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="534" mass="55493" checksum="8A61FB5A2CAADC51" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TS5</accession>
    <name>Q39TS5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Menaquinol oxidoreductase complex, membrane protein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">pcmD</name>
        <name evidence="12" type="ordered locus">Gmet_2120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513085.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2120"/>
    <dbReference type="EnsemblBacteria" id="ABB32349">
        <property type="protein sequence ID" value="ABB32349"/>
        <property type="gene ID" value="Gmet_2120"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2120"/>
    <dbReference type="eggNOG" id="COG1290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132021_0_0_7"/>
    <dbReference type="OMA" id="DRNPKGT"/>
    <dbReference type="OrthoDB" id="1712332at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_CTER" evidence="11">
        <location>
            <begin position="31"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="173" mass="19361" checksum="A153A6C00E9E9464" modified="2005-11-22" version="1">MQAAKKEEIFPKDPNKTYSLMAIVDGDSFQVEKGPEDTVQSWPHLMVRELGLFLLVLAVIMGVSLIFNAPLEEAANPQHSTNPAKAPWYFVGIQELVSYSALLGGIVTPAIIVVTLLLLPYLDRNPKGTGVWFSRDRRVATILFTVFVVAMLILIVIGQFLRGPNWHLYLPWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U33</accession>
    <name>Q39U33_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Undecaprenyl-diphospho-oligosaccharide flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2012</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512938.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2012"/>
    <dbReference type="EnsemblBacteria" id="ABB32241">
        <property type="protein sequence ID" value="ABB32241"/>
        <property type="gene ID" value="Gmet_2012"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2012"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026911_3_1_7"/>
    <dbReference type="OMA" id="DWWFYYQ"/>
    <dbReference type="OrthoDB" id="564091at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="329"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="483" mass="53765" checksum="82B4226BF44093B6" modified="2005-11-22" version="1">MTSLKKKTFENVAYIGVARIVALVFQSIANIILSRALTSSDYGLVGFATIFVNFFSQFSDLGLNSAVVHRKQLDDTALHTGFTMKLGIGLFLYIIAFCASGLAVFFFDNPGVVGVIKLLALNFIINSFSFIPTTMLKRELDYKKIASATVCQTMVNSSLAMILALAGFKYWSIVIANICATLAMILTLNYLKPVKIKFAFDRESARQFMSYGTSLSLTGFIVFTIFNVDNFIIGAVKGSTELGYYMIAFNWGSIICVILGTVVNSVLFPTFSRMEQDRGRIKRSYFRVLEYVSFVGILANVTLLLISRDFLVHVLGHGTDKWLPALQSLRILCAYGIVRFLLEPLGNVLMALDMNKVLLKTTALSAIIEVVLIYPMLKFYGIEGVSLLITATYLVQYGIYYPIVKKTTDIQFSEFVSATKDAFLSASVIIALSLFLRDYFSAESVMGVVAKVIVIAFIYFVLHGLLNKWKLVREAREMLLGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U40</accession>
    <name>Q39U40_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase and DUF3473 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512945.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2005"/>
    <dbReference type="EnsemblBacteria" id="ABB32234">
        <property type="protein sequence ID" value="ABB32234"/>
        <property type="gene ID" value="Gmet_2005"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2005"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066872_0_0_7"/>
    <dbReference type="OMA" id="FYFHPWE"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10941">
        <property type="entry name" value="CE4_PuuE_HpPgdA_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045235">
        <property type="entry name" value="CE4_PuuE_HpPgdA-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022560">
        <property type="entry name" value="DUF3473"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014344">
        <property type="entry name" value="PEP-CTERM_polysacc_deacetyl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11959">
        <property type="entry name" value="DUF3473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03006">
        <property type="entry name" value="pepcterm_polyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="24"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="280" mass="32030" checksum="3896DA658B1EA1EF" modified="2005-11-22" version="1">MLNALSFDIEDWFQVENLKGAIAADSWDTCDLRVVNNTRKILDLLRRHQTRATFFILGWVAERCPDLVREIADAGHEIASHGYGHELVYTQTPEEFRRDLRRSKEILEGLTGMAVRGYRAPSFSVNPETPWALDVLVDEGFTYDSSVFPTSFHDRYGFSGSSLSPFRFDNGLVEVPLSTVRFGGKNIPAAGGGYFRLFPYPFFRYLAKRINGEGRALVFYLHPWELDPEQPRIPIRHDYRFRHYVNLCKTGRRLDRLLGDFRFGAMGELVARVGGKVAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U63</accession>
    <name>Q39U63_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GTP-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1982</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512969.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1982"/>
    <dbReference type="EnsemblBacteria" id="ABB32211">
        <property type="protein sequence ID" value="ABB32211"/>
        <property type="gene ID" value="Gmet_1982"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1982"/>
    <dbReference type="eggNOG" id="COG1100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077110_1_0_7"/>
    <dbReference type="OMA" id="LFFDFTP"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="289" mass="30813" checksum="C2ADFA035CD885F9" modified="2005-11-22" version="1">MALFNRTKREINAKIVYFGSPLAGKATTLQFIHRKLKPECRGPMKTMGGQSDRMLFFDFMPPELGEVNDYRVRFHLYTVQGEVTNRSTWKTVLKGADGIVFVADASPESAAITRESMENLRECLRSYGQDLEKLPCVVQCNKSDLPDALSTEELAQLVDSAGFPVIRSASRTGEGILQVLSSVVKGVMNALRDQEGSVTADSSVGLAGMGSEDEQAPVERGEKMATVPTDLAERVDTLPGAAVPTLAMGGAVTVAADGTLQVPLTVGCGGAERGFVLTLELTPAASVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UH5</accession>
    <name>Q39UH5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GDP-mannose--undecaprenyl-phosphate mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511975.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1870"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32099">
        <property type="protein sequence ID" value="ABB32099"/>
        <property type="gene ID" value="Gmet_1870"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1870"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_13_0_7"/>
    <dbReference type="OMA" id="TAYIHGF"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="PTHR43398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="246" mass="27674" checksum="25F4D2DA3EC77089" modified="2005-11-22" version="1">MKVYVVVPTYNESDNIVALMEKILAQRDNIHVLVVDDNSPDGTGEIAARMSSDNPRIHVLRRSGKMGLGSAYCDGFRVALRDGADFIIEMDADFSHDPATIPALLAATDKYDVVVGSRYLNGVSVVNWPIRRLMLSYFASVYTRFVTGLALRDCTSGFKCFRRRVIESVDLDTIRSDGYSFQIEMNYRCVERGFRVGEIPIIFIDRHAGSSKMSKKIVREAVLMVWKLKLGSLVKKLTRRGDRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UM2</accession>
    <name>Q39UM2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid ABC transporter, periplasmic amino acid-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livK</name>
        <name evidence="5" type="ordered locus">Gmet_1823</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the leucine-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512022.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1823"/>
    <dbReference type="EnsemblBacteria" id="ABB32052">
        <property type="protein sequence ID" value="ABB32052"/>
        <property type="gene ID" value="Gmet_1823"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1823"/>
    <dbReference type="eggNOG" id="COG0683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027128_0_1_7"/>
    <dbReference type="OMA" id="APMIVEE"/>
    <dbReference type="OrthoDB" id="776281at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028081">
        <property type="entry name" value="Leu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000709">
        <property type="entry name" value="Leu_Ile_Val-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028082">
        <property type="entry name" value="Peripla_BP_I"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13458">
        <property type="entry name" value="Peripla_BP_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00337">
        <property type="entry name" value="LEUILEVALBP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53822">
        <property type="entry name" value="SSF53822"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223149" evidence="3">
        <location>
            <begin position="25"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peripla_BP_6" evidence="4">
        <location>
            <begin position="27"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="380" mass="40100" checksum="A146D47AA53C2386" modified="2005-11-22" version="1">MLKKSSFILTFVVSLALLAGSALAAPPIKIGGLFAVTGPASFLGEPERNTAQMVVNGINAAGGVKGRKLELIAYDTQGDATKAVQAANRLIKEDKVAAIIGPSTTGDTMAVIPVVERARIPMISCAAGSKITEPVKKWIFKTAQNDGLAVARIYGDLKRKKISKIAILTVSDGFGSSGREQLKAQASAYGIRIVSDDTYGPKDTDMTAQLTKIKGSGAQAVICWGTNPGPAVVARNAKQLGLKLPLYMSHGVSSKKFIGLAGGAAEGILLPSGRVIVADLLPNSDRQKKSLLAFVKDYQKHYKAEGDHFGGHAWDAIMLLKGAIERGGENPAAIRDQLERTRGFAGIGGVFSYSPSDHAGLTKDAFVLVEIRKQDFALVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UN0</accession>
    <name>Q39UN0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavodoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512030.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1815"/>
    <dbReference type="EnsemblBacteria" id="ABB32044">
        <property type="protein sequence ID" value="ABB32044"/>
        <property type="gene ID" value="Gmet_1815"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1815"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050993_1_0_7"/>
    <dbReference type="OMA" id="MADAVHC"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN_red" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="224" mass="24550" checksum="B6E218AFF35C60A0" modified="2005-11-22" version="1">MKILAILASPRGTRGNTGRLLDEVLAGAREAGAETEVLSLSALKVQPCVGCDNCHKTGICPINDDYEGIKEKLLACDGFILASPNYIFSVTAQMKALFDRCNGMIHCMALEGKYAAVVETSGGGEDADVISYMERVINMLGATSAGGIGSPVAGVRTFPDEATLYGKASALGRDLCRCISEKRRFPDQERFHEAFRSRMSGLVDFMKEFWLFERDYWQKKTLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UX2</accession>
    <name>Q39UX2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513382.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1721"/>
    <dbReference type="EnsemblBacteria" id="ABB31952">
        <property type="protein sequence ID" value="ABB31952"/>
        <property type="gene ID" value="Gmet_1721"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1721"/>
    <dbReference type="eggNOG" id="COG1607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_768885_0_0_7"/>
    <dbReference type="OMA" id="PLAQDPW"/>
    <dbReference type="OrthoDB" id="1712258at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="2">
        <location>
            <begin position="198"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="347" mass="39703" checksum="12EDDD1629FAA30E" modified="2005-11-22" version="1">MTTPTETSLYRTLSLGSEPKHRRRFMVVDEEIPGNFRFGLLLEELDILAEQTAIAYVRRFHPEGRVVTAAIDNILVRHVVDVNRDIVMHARINHVGRSSLEVGIRVEHAGDPATHIASCYFTMVARGGEGAGESIPLPPLEYGDELEQQRAAKAIADREEYRRQQASLLEPPSREEYEMLDRLHRDQEEPGFTGHPAGRLVADAWERMYPEQEYVPQRIFGGYLIRRAYELSAICSEQVAPDRSIIAAVNRINFFHPVRIGDKLHFTSRVVYTNESFVCVEASIERISRDRTASALSNSCLFTFVNVDRELNHRPVPPIYPATYREDARYLEAYRSYQAIAGHYRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V24</accession>
    <name>Q39V24_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ligand-gated TonB-dependent outer membrane channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511394.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1669"/>
    <dbReference type="EnsemblBacteria" id="ABB31900">
        <property type="protein sequence ID" value="ABB31900"/>
        <property type="gene ID" value="Gmet_1669"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1669"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_16_0_7"/>
    <dbReference type="OMA" id="WAGWGKA"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="58"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="195"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="676" mass="76374" checksum="6D7569E5BA4A7911" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V61</accession>
    <name>Q39V61_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MoxR family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511432.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1632"/>
    <dbReference type="EnsemblBacteria" id="ABB31863">
        <property type="protein sequence ID" value="ABB31863"/>
        <property type="gene ID" value="Gmet_1632"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1632"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034716_2_0_7"/>
    <dbReference type="OMA" id="NRFQMND"/>
    <dbReference type="OrthoDB" id="895310at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011703">
        <property type="entry name" value="ATPase_AAA-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07726">
        <property type="entry name" value="AAA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="37"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="313" mass="33716" checksum="9203C89A48E1E6D9" modified="2005-11-22" version="1">MNLAKRAEMLHVIDTLATHYLKGKVRAVRLSVIALLSGGHILLEDIPGLGKTTLALALAKALGLSFGRVQCTSDLLPTDITGLSIFNREESRFTFVSGPIFNNVVLVDEINRAMPKTQSALLEAMEERKVTVEGTTHHLPGPFLVIATQNPVEQVGTYPLPESQLDRFMVRSGIGYPPDIIEKAIIKGGSIRDGIQSLEPLVSANDIAEAQRAVKEGVYLSDTVVDYLYTIVAATRNHPAISSGISTRGAIGMAETAKAHAYLEGRDYVIPEDVKAIAVPVGAHRLILTMENENLDKGELLNAVLNAIPVPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V82</accession>
    <name>Q39V82_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1611"/>
    <dbReference type="EnsemblBacteria" id="ABB31842">
        <property type="protein sequence ID" value="ABB31842"/>
        <property type="gene ID" value="Gmet_1611"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1611"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4728">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1649701_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023387">
        <property type="entry name" value="DUF1653-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037135">
        <property type="entry name" value="DUF1653-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07866">
        <property type="entry name" value="DUF1653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="17884" checksum="36371074A44097DF" modified="2005-11-22" version="1">MVVVGGWVSICFWAWRRGRKGKCVNDKIGPGLYRHYKGNLYRVIGVARHSETEEEVVVYRCLYGDGSLWVRPLVMFAETVTVDGNLVARFERRDEANVSPCIDGNRCKGCGRCVSVCRDRLISLESGEGRKVAVMGERRRCDLCGRCIAECLFGAISLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VB6</accession>
    <name>Q39VB6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase, ArgK family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511489.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1576"/>
    <dbReference type="EnsemblBacteria" id="ABB31808">
        <property type="protein sequence ID" value="ABB31808"/>
        <property type="gene ID" value="Gmet_1576"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1576"/>
    <dbReference type="eggNOG" id="COG1703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043725_1_0_7"/>
    <dbReference type="OMA" id="DWRPPIV"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005129">
        <property type="entry name" value="GTPase_ArgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00750">
        <property type="entry name" value="lao"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="42"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="320" mass="35048" checksum="63045BC187F3763C" modified="2005-11-22" version="1">MSLAQRILDSDLRAAARLMRDLDDGFRSAAEEMKSLYPHTGRAFILGITGPPGAGKSTLVDQLTAAYRQRGRRVGVVAIDPTSPFTGGAILGDRIRMNRHAEDPGVFIRSLATRGHMGGLSRSTGDVVNVMDAMGMDVVIIETVGVGQDEIDIVRMAHTTVVVSVPGLGDDIQAIKAGVLEIGDLFVVNKADREGADRTARELAAMLEMKQAKPGDWQPKVLLTEASRNKGIEELVDEIEAHHGHLVNSGALERLKEERCARQFMDLLRERLFAEVYGHIHVNGRFREIVEDMAARRTDPYSAVEMIIAERFSGRQASNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VG0</accession>
    <name>Q39VG0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-[hydroxy(Phenyl)methyl]-succinyl-CoA dehydrogenase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bbsC</name>
        <name evidence="1" type="ordered locus">Gmet_1530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511537.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1530"/>
    <dbReference type="EnsemblBacteria" id="ABB31764">
        <property type="protein sequence ID" value="ABB31764"/>
        <property type="gene ID" value="Gmet_1530"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1530"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="EFHSCDV"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="248" mass="25914" checksum="EF8534F9A2960612" modified="2005-11-22" version="1">MKDRTALIVGAANDIGGAISVRFAKLGARVVLIDTDRQELDKVSALVAAAGGEAEVIAVDGADSGAVKSTIDGIAGKHGSIDILVNAIDHRDGVPITEGTVETWERSLKENITPLVSFSLNVIPVMKNNKYGRIVNIGSLDYLGTAKQANYSTAKSAIFGLTRSFALELAKDGITVNQILKGDVKTAECPLSPEEEEKGAAKLPVQRLGKPEDIAYAAAYFASGLSGYVTGQNLIVCGGKSIYSSMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VH5</accession>
    <name>Q39VH5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511552.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1515"/>
    <dbReference type="EnsemblBacteria" id="ABB31749">
        <property type="protein sequence ID" value="ABB31749"/>
        <property type="gene ID" value="Gmet_1515"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1515"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074356_1_0_7"/>
    <dbReference type="OMA" id="EFDHEKY"/>
    <dbReference type="OrthoDB" id="963283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033399">
        <property type="entry name" value="Put_LolA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17131">
        <property type="entry name" value="LolA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223170" evidence="1">
        <location>
            <begin position="29"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="268" mass="30604" checksum="26C2313AAC60DA5C" modified="2005-11-22" version="1">MSNKKTMVTSLVVIAAVISALLAGTVFAAPDARALLKESENRHRSKTQQYSGNLAVVNREGKVRKKGWKSYRQGYAGDAKTLTRFTDPPEVKEVGFLSISRPAGQNDDQWLYLPSMKRERRIAAQDRDASFVGTDFNYEDMEEFDHEKYRVTLQGEQTVDGQPCYVIAAFPLEGAGRSVYEKKILYLRKDILYLLRMDLYRKGDKQPSKIFTLSDLQHLEGHWVAKKWEMSDLRKGSRTTVVLDRISYDKPQPVGRFTLQNLNREGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VI7</accession>
    <name>Q39VI7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Exopolysaccharide synthesis membrane protein H (Exosortase) and periplasmic protein I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">epsHI</name>
        <name evidence="11" type="ordered locus">Gmet_1503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511564.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1503"/>
    <dbReference type="EnsemblBacteria" id="ABB31737">
        <property type="protein sequence ID" value="ABB31737"/>
        <property type="gene ID" value="Gmet_1503"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1503"/>
    <dbReference type="eggNOG" id="COG1269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039817_1_0_7"/>
    <dbReference type="OMA" id="VDHLIYG"/>
    <dbReference type="OrthoDB" id="1832262at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013426">
        <property type="entry name" value="EpsH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026491">
        <property type="entry name" value="ExosortD_VPLPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014263">
        <property type="entry name" value="Methanolan_biosynth_EpsI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11984">
        <property type="entry name" value="DUF3485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02602">
        <property type="entry name" value="8TM_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02914">
        <property type="entry name" value="EpsI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04152">
        <property type="entry name" value="exosort_VPLPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3485" evidence="10">
        <location>
            <begin position="321"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="526" mass="59562" checksum="015E70144164C9AF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VP9</accession>
    <name>Q39VP9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase IV</fullName>
            <shortName evidence="12">Pol IV</shortName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">dinB</name>
        <name evidence="14" type="ordered locus">Gmet_1441</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31675.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511628.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1441"/>
    <dbReference type="EnsemblBacteria" id="ABB31675">
        <property type="protein sequence ID" value="ABB31675"/>
        <property type="gene ID" value="Gmet_1441"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1441"/>
    <dbReference type="eggNOG" id="COG0389">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012348_1_2_7"/>
    <dbReference type="OMA" id="CKPDGLL"/>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd03586">
        <property type="entry name" value="PolY_Pol_IV_kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01113">
        <property type="entry name" value="DNApol_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022880">
        <property type="entry name" value="DNApol_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024728">
        <property type="entry name" value="PolY_HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11798">
        <property type="entry name" value="IMS_HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="SSF100879"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="SSF56672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 12" id="KW-0515">Mutator protein</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="13">
        <location>
            <begin position="6"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Substrate discrimination" evidence="12">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB31675.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="413" mass="46393" checksum="24063EB42301CAA6" modified="2012-10-31" version="2">MSGRVIMHVDMNAFFASVEQQHDPALRGKPIAVIGSAARTVITTASYEARAFGVKTGMTVWQAQQKCPQIILVTGDNRKYTYTSARIVEMMKQFTPLVEVFSIDEAFLDVTGSLSLYSSAERIAFLLKAEIRHHFGLTCSIGIAPNKLLAKLASEMKKPDGLTVIKPDDVAPVLETLPIKELCGIGAKMECQLNLLGIRTCGELGRYPVDRLMRKFGIVGEKLHLMGQGIDDSPVVPHEEAEEVKSVGHSTTLEHDIEDRREILRWLLQLSEMVGRRARRYNVWGKTVTLSIRYADFDTWVGRQETLPHHINQSDDIYRAAVAILDTLVLEQPVRLLGVRLSNLRYESNQLPLFEEERKKVLLAGAMDQVNDRFGDFAVTFGSLLDKERRQEKGSHVISPAWRPEGIRNVDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VU1</accession>
    <name>Q39VU1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Geopilin domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilA-N</name>
        <name evidence="2" type="ordered locus">Gmet_1399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511668.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39VU1"/>
    <dbReference type="STRING" id="269799.Gmet_1399"/>
    <dbReference type="EnsemblBacteria" id="ABB31633">
        <property type="protein sequence ID" value="ABB31633"/>
        <property type="gene ID" value="Gmet_1399"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1399"/>
    <dbReference type="eggNOG" id="COG4968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188312_0_0_7"/>
    <dbReference type="OMA" id="YRAKAYN"/>
    <dbReference type="OrthoDB" id="2073273at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="69" mass="7819" checksum="78D8322249646D95" modified="2005-11-22" version="1">MLQKLRNKKGFTLIELLIVVAIIGILAAIAIPQFAAYRQKAFNSAAESDLKNTKTNLESYYSEHQFYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W03</accession>
    <name>Q39W03_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1336</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513170.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1336"/>
    <dbReference type="EnsemblBacteria" id="ABB31571">
        <property type="protein sequence ID" value="ABB31571"/>
        <property type="gene ID" value="Gmet_1336"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1336"/>
    <dbReference type="eggNOG" id="COG1373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041527_3_1_7"/>
    <dbReference type="OMA" id="NYSNVAQ"/>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041682">
        <property type="entry name" value="AAA_14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025420">
        <property type="entry name" value="DUF4143"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13173">
        <property type="entry name" value="AAA_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13635">
        <property type="entry name" value="DUF4143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_14" evidence="1">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4143" evidence="2">
        <location>
            <begin position="178"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="394" mass="43897" checksum="0ADCC73EAABE4A06" modified="2005-11-22" version="1">MISRALYPFLSEALDSSPAVALLGPRQVGKTTLALEIGKVRGALYLDLESEQDLAKLAQPELYLEDHQDRLVIFDEVHRLPGLFPVLRGFIDKGRRAGLRTGRFLLLGSASLDLLKQSGETLAGRISYLELSPFNILETGERTSEDLWVAGGFPESLLAKNPRQSLRWRQDFIRTYLERDIPQFGPRIAAEALRRFWVMLAHNQGGVLNAAQFSRNLGVDVKTVTNYLDLLVDLMLVRRLPPWHGNIGKRLVKSPKVYVRDSGLVHALLGIQDKEGLLAHPVVGQSWECFVVENLLGAGIGAPQGFFYRTGGGAEIDLLLTWPDEEIWAVEIKRSLSPRPERGFYSACSDLAPAKKYVVYPGAERYRIAPDIEAIPLPQLAAEIHAKAILNVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W33</accession>
    <name>Q39W33_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, Ros/MucR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ros/MucR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512061.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1305"/>
    <dbReference type="EnsemblBacteria" id="ABB31541">
        <property type="protein sequence ID" value="ABB31541"/>
        <property type="gene ID" value="Gmet_1305"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1305"/>
    <dbReference type="eggNOG" id="COG4957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106247_3_0_7"/>
    <dbReference type="OMA" id="MKTLTRH"/>
    <dbReference type="OrthoDB" id="1797085at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1550">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041920">
        <property type="entry name" value="ROS/MUCR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008807">
        <property type="entry name" value="ROS_MUCR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05443">
        <property type="entry name" value="ROS_MUCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="166" mass="18083" checksum="BE81150A3A3F4138" modified="2005-11-22" version="1">MASTLLELTAGIVSSHAAMSELSTEELVQEIQKVYTTLQQLEGGAPEAAQAEETKAPVISLKKAFQADQVVCMICGKGGMKTLTRHLAQVHDMKPREYRKQFNIPSSQALTARKFSEARKKMAQERGLADNLAKARAVRATKIQEKKGAPAEKPAKPKGAPRKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W46</accession>
    <name>Q39W46_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31528.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365799.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1292"/>
    <dbReference type="EnsemblBacteria" id="ABB31528">
        <property type="protein sequence ID" value="ABB31528"/>
        <property type="gene ID" value="Gmet_1292"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1292"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_3_7"/>
    <dbReference type="OMA" id="EPQWSAK"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="109"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31528.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="330" mass="37625" checksum="18A4DE8981B7C637" modified="2012-10-31" version="2">MQTRQGGATQNTMKWLKRLVNPLMALIGIQVVWGLLVFFWITWFVGRHKEFRELAERYRPELLGRGFDWAVLVEGIVLLVIILVGVYVIFIYWRRQSNLNLEQKDFISQATHELKSPLASIKLHLETIRLRKPPPEKLERFLDTMLVDIDRLDNLTSNILMVAKLEQRRRASQYPVVDFSALVTRYMDQQRHVLPEGGNVILDIEKGISAAIDVEGMETVLRNLFENAILYSIGAPEIRVTLKRDGNRCTLSFQDNGKGIDRKDLKNVFRKFYRIRSSGEAIRGTGLGLWIVKSVVKEHGGTVTATSAGIGEGTSFIISLPLPRRKRGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W53</accession>
    <name>Q39W53_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HPr kinase/phosphorylase</fullName>
            <shortName evidence="10">HPrK/P</shortName>
            <ecNumber evidence="10">2.7.11.-</ecNumber>
            <ecNumber evidence="10">2.7.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">HPr(Ser) kinase/phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 13" type="primary">hprK</name>
        <name evidence="13" type="ordered locus">Gmet_1285</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[HPr protein]-L-serine + ATP = [HPr protein]-O-phospho-L-serine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46600"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>[HPr protein]-O-phospho-L-serine + H(+) + phosphate = [HPr protein]-L-serine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:46604"/>
            <dbReference type="Rhea" id="RHEA-COMP:11602"/>
            <dbReference type="Rhea" id="RHEA-COMP:11603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homohexamer.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The Walker A ATP-binding motif also binds Pi and PPi.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="10">Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the HPrK/P family.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="10"/>
    <dbReference type="EC" id="2.7.4.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512081.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1285"/>
    <dbReference type="EnsemblBacteria" id="ABB31521">
        <property type="protein sequence ID" value="ABB31521"/>
        <property type="gene ID" value="Gmet_1285"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1285"/>
    <dbReference type="eggNOG" id="COG1493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052030_0_1_7"/>
    <dbReference type="OMA" id="AMNNRQK"/>
    <dbReference type="OrthoDB" id="391150at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01918">
        <property type="entry name" value="HprK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01249">
        <property type="entry name" value="HPr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003755">
        <property type="entry name" value="HPr(Ser)_kin/Pase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011104">
        <property type="entry name" value="Hpr_kin/Pase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011126">
        <property type="entry name" value="Hpr_kin/Pase_Hpr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF1">
        <property type="entry name" value="PTHR30305:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07475">
        <property type="entry name" value="Hpr_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02603">
        <property type="entry name" value="Hpr_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00679">
        <property type="entry name" value="hpr-ser"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hpr_kinase_N" evidence="11">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Hpr_kinase_C" evidence="12">
        <location>
            <begin position="136"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of both phosphorylation and dephosphorylation" evidence="10">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for the catalytic mechanism of dephosphorylation" evidence="10">
        <location>
            <begin position="270"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for phosphorylation activity. Proton donor; for dephosphorylation activity" evidence="10">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="159"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="319" mass="35559" checksum="05939C80861CB157" modified="2005-11-22" version="1">MNTISLSIEDLLNDTEYGLDLSLVAGRGGVGHRVFSSRIQKPGLALTGYTDHLHPDRVQVLGNTEISYLRQLHEELATIFVDKFCEYPISCIIVTKGLDPPQFLKDAAEREAIPLLVTPLQSSTFISLITKFLEERLLPTTHIHGVLVDVLGVGVLLLGKSGIGKSECALDLVIRGHRLVADDVVFVKKKMPAALVGQAAEAIQYHIEIRGLGVLNIKNLFGVSSIREKKIIEMVIELVEWDPQQEYDRLGLDDEVYTILDLELPYIKIPVRPGRNLTSIIEVAARNHLLKGMGYHSAREFQEKLLARMENRPLGDEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W55</accession>
    <name>Q39W55_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase sigma-54 factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">rpoN</name>
        <name evidence="13" type="ordered locus">Gmet_1283</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the sigma-54 factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512083.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1283"/>
    <dbReference type="EnsemblBacteria" id="ABB31519">
        <property type="protein sequence ID" value="ABB31519"/>
        <property type="gene ID" value="Gmet_1283"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1283"/>
    <dbReference type="eggNOG" id="COG1508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020569_1_1_7"/>
    <dbReference type="OMA" id="VTTQKFM"/>
    <dbReference type="OrthoDB" id="1906842at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001216">
        <property type="term" value="F:DNA-binding transcription activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000394">
        <property type="entry name" value="RNA_pol_sigma_54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007046">
        <property type="entry name" value="RNA_pol_sigma_54_core-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007634">
        <property type="entry name" value="RNA_pol_sigma_54_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038709">
        <property type="entry name" value="RpoN_core-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32248">
        <property type="entry name" value="PTHR32248"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00309">
        <property type="entry name" value="Sigma54_AID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04963">
        <property type="entry name" value="Sigma54_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04552">
        <property type="entry name" value="Sigma54_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000774">
        <property type="entry name" value="RpoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00045">
        <property type="entry name" value="SIGMA54FCT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02395">
        <property type="entry name" value="rpoN_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00717">
        <property type="entry name" value="SIGMA54_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00718">
        <property type="entry name" value="SIGMA54_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="8 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Sigma54_CBD" evidence="12">
        <location>
            <begin position="120"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma54_DBD" evidence="11">
        <location>
            <begin position="323"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="483" mass="55246" checksum="18306242C2B1EFFD" modified="2005-11-22" version="1">MAIEMRQQMKLTQQLVMTPQLQQAIKLLQLSRLELQDLVRQEMEENPVLEETLELEEPKEQDQLEQSEKEETPSGEDNKEFQEVKAGEETLRETDWDSYLEGYNFSAGEQYYDDEDRPSYENVLTRKGTLGDHLMWQLSLTRFSDVETAVGAEIIGNIDEDGYFRATVEEIARSQGVDEALVETCLKKVQEFDPMGVGARDLRECLLIQVEQLGMGGSVVEGILRHHLHDLEARKYKQIAKALGVDINDVLMGARIIAGFDPKPGRVYGSEDVHYISADIFVYKIGEDYVVVLNDEGLPNLRISPYYAGEAKASGQVDAKAEEYINDKVRSAMWLIKSIHQRQRTIYKVAKSISKFQRDFLDKGIEYLRPLVLRDVAEDIGMHESTISRVTTNKYMQTPQGLFEMKYFFNSGISTGEGDFIASESVKNKIKEIVEAEDPRKPYSDQRIADLLSAHSINIARRTVTKYREMLRIGSSSERKRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WA8</accession>
    <name>Q39WA8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sodium/solute symporter, GAF and PP2C family protein serine/threonine phosphatase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_1230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512139.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1230"/>
    <dbReference type="EnsemblBacteria" id="ABB31466">
        <property type="protein sequence ID" value="ABB31466"/>
        <property type="gene ID" value="Gmet_1230"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1230"/>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_22_2_7"/>
    <dbReference type="OMA" id="YDIFSTV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="domain" description="GAF" evidence="9">
        <location>
            <begin position="675"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="PPM-type phosphatase" evidence="10">
        <location>
            <begin position="862"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1100" mass="121669" checksum="65FDE2BF63D42DC2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WH0</accession>
    <name>Q39WH0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YggT family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513431.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1166"/>
    <dbReference type="EnsemblBacteria" id="ABB31404">
        <property type="protein sequence ID" value="ABB31404"/>
        <property type="gene ID" value="Gmet_1166"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1166"/>
    <dbReference type="eggNOG" id="COG0762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136788_1_0_7"/>
    <dbReference type="OMA" id="WLINFQV"/>
    <dbReference type="OrthoDB" id="2069856at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003425">
        <property type="entry name" value="CCB3/YggT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33219">
        <property type="entry name" value="PTHR33219"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02325">
        <property type="entry name" value="YGGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="105" mass="11928" checksum="080D694F009357D1" modified="2005-11-22" version="1">MFVLANFLLAVAKIADILLTIYLYILIARAIISWVNPDPYNPIVNFLYRSTEPVLSRVRRFLPDMGGLDLSPIIVLVAIYFLQSFLVRSIYDLAYKMKLGMGGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WL0</accession>
    <name>Q39WL0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetate transporter AcpA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1126</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513390.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1126"/>
    <dbReference type="EnsemblBacteria" id="ABB31364">
        <property type="protein sequence ID" value="ABB31364"/>
        <property type="gene ID" value="Gmet_1126"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1126"/>
    <dbReference type="eggNOG" id="COG1584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051062_3_0_7"/>
    <dbReference type="OMA" id="WKKGNTF"/>
    <dbReference type="OrthoDB" id="1399490at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="203" mass="21580" checksum="D20C89CC18838A00" modified="2005-11-22" version="1">MATNPQDTAAVFELNDTTANPAPLGLLGFGMTTVLLNLHNAGMFPMDAMILSMGIFYGGLGQIIVGIMEWRKNNTFGATAFTSYGLFWLTLVALIILPNTGFIQAPDNSAMTAYLVMWGLFTGVLFVGTLRMNKALQVVFGSLTVLFFLLAAGDATGNHAIKIIAGYEGIFCGLSAIYAGLAQVINEVYGRTVAPLGLVRQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WN5</accession>
    <name>Q39WN5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Alanine dehydrogenase</fullName>
            <ecNumber evidence="2 4">1.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ald</name>
        <name evidence="10" type="ordered locus">Gmet_1099</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>H2O + L-alanine + NAD(+) = H(+) + NADH + NH4(+) + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:18405"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="EC" id="1.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <dbReference type="EC" id="1.4.1.1" evidence="2 4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513755.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1099"/>
    <dbReference type="EnsemblBacteria" id="ABB31339">
        <property type="protein sequence ID" value="ABB31339"/>
        <property type="gene ID" value="Gmet_1099"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1099"/>
    <dbReference type="eggNOG" id="COG0686">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003376_3_0_7"/>
    <dbReference type="OMA" id="HPYYHLY"/>
    <dbReference type="OrthoDB" id="673280at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000286">
        <property type="term" value="F:alanine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05305">
        <property type="entry name" value="L-AlaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008141">
        <property type="entry name" value="Ala_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42795">
        <property type="entry name" value="PTHR42795"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000183">
        <property type="entry name" value="Alanine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00518">
        <property type="entry name" value="alaDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AlaDh_PNT_N" evidence="9">
        <location>
            <begin position="4"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="AlaDh_PNT_C" evidence="8">
        <location>
            <begin position="147"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="268"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="237"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="265"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="296"/>
            <end position="299"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000183-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="365" mass="38143" checksum="BF7AFD95D2F0041D" modified="2005-11-22" version="1">MIVGVPREIKTHEYRVGMTPAGIAELARGGHTVLVETGAGEGSGFADGEYLRVGARVCGREEVFGPAELLVKVKEPLPSEYGLLRQGQALFTYLHLAPNRPLAELLLERGVTGIGYETFEKGGTLPLLAPMSEVAGRMAPLVGGYHLQRVLGGTGVLPSGVPGVPAARALILGAGVVGSGAARVCAGLGMETVVMNRGIDRLQRLDEILAGRARTVALNRESLAEELSRADLVVGAVLVPGGRTPLLIDRSALGTMKRGSVIVDVSIDQGGCAETSRPTTHDDPVYIVDGVIHYTVANMPGAYPRTSTLALTNATLPCVKALADRGIEDALRADPALAGALNTWRGAVVHRALAQALDLPFSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WP0</accession>
    <name>Q39WP0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cccA</name>
        <name evidence="7" type="ordered locus">Gmet_1094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513750.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1094"/>
    <dbReference type="EnsemblBacteria" id="ABB31334">
        <property type="protein sequence ID" value="ABB31334"/>
        <property type="gene ID" value="Gmet_1094"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1094"/>
    <dbReference type="eggNOG" id="COG1858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041010_0_0_7"/>
    <dbReference type="OMA" id="DCHANGH"/>
    <dbReference type="OrthoDB" id="52724at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223383" evidence="5">
        <location>
            <begin position="30"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="362"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="469" mass="52474" checksum="47BABADE23FC8488" modified="2005-11-22" version="1">MDGKNRPSTRRMVLLAGAVALASATVTLAEERIVGKTSYAPVAGTEAFSTVKETMEKQKTAVMKRQMDLLGMRYDLADKAMQGVTMSRGKGVQEGVRVKLPAGTTWQQLAAMSPETIREKGLFPKGFLPLPHPNHPEGGMVFPKFHIDEVKKQTARDLTRFDLDFDIPDHFLPEFPAPIYLTTRPDLGDVSQGKLVTTQNFFELFNGILNPKQLEGLRLLLTPFPQQQFNATTDRRSAEPSLGVACFDCHANGHTNASTHLVGDIRPQELRHRLDTPPLRGVNIQRLFGSQRAMKSVEDFTEFEQRAAYFDGDPVIATKKGVNILERGSQVHFMAEFQNILDFPPAPKLTVFGKLDPEKAGEAELRGQEIFFGKARCAECHPAPYYTDNLMHNLRTERFYRPETMNGRLASADGPIKTFPLRGIKESPPYLHDGRLLTLADTIEFFNLVTGVKLTDEEKKDLLAFMLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WX2</accession>
    <name>Q39WX2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513180.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1010"/>
    <dbReference type="EnsemblBacteria" id="ABB31252">
        <property type="protein sequence ID" value="ABB31252"/>
        <property type="gene ID" value="Gmet_1010"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1010"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_6_0_7"/>
    <dbReference type="OMA" id="NRFGVTC"/>
    <dbReference type="OrthoDB" id="1893149at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="10"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="153" mass="17302" checksum="033C03CA10CF17A6" modified="2005-11-22" version="1">MRIEYVKVVPDVYRAMMCLEHQVEKSGLESPLLDLIKMRASQINGCAYCIDMHSKDARARGETEQRLYELDAWRESPFYTEREQAALAWTEALTLVTNGHVPNGVYEEARKQFTDVELVNLTLAVVAINGWNRLGIAFRSVPGGYHPASGLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WX6</accession>
    <name>Q39WX6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain iron-sulfur cluster-binding oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1006</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513176.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1006"/>
    <dbReference type="EnsemblBacteria" id="ABB31248">
        <property type="protein sequence ID" value="ABB31248"/>
        <property type="gene ID" value="Gmet_1006"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1006"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044176_1_0_7"/>
    <dbReference type="OMA" id="YHFYPGS"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027596">
        <property type="entry name" value="AmmeMemoSam_rS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01101">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04337">
        <property type="entry name" value="AmmeMemoSam_rS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="67"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="336" mass="37252" checksum="9C2B9FA48B1D30AA" modified="2005-11-22" version="1">MKEAMFYKRESGNRAHCGLCRHRCMIADGSRGICAVRENRGGTLYSLVYGKLVAENVDPIEKKPLFHVLPGSKSFSIATMGCNFRCHHCQNYSISQVAPKGPVAGIQQTPESVVEKALATGSRSIAYTYTEPTIFFEFAYDTARLARQAGLLNVFVTNGYITREALTAIAPYLDAANIDLKGFTEDFYRDYVHGRLSEVLDSIIEYRKQGIWIELTTLVIPGLNDSDGELKGIASFIVDNLGADTPWHVTQFYPTYKLTDRPRTPVETLRRARDIGKAAGLNYVYEGNVPGEGGENTWCPSCSALLIERYGYLIENNQIRDGRCPDCGTTIVGIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WY8</accession>
    <name>Q39WY8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0994</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365757.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0994"/>
    <dbReference type="EnsemblBacteria" id="ABB31236">
        <property type="protein sequence ID" value="ABB31236"/>
        <property type="gene ID" value="Gmet_0994"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0994"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008393_0_0_7"/>
    <dbReference type="OMA" id="FNWENEL"/>
    <dbReference type="OrthoDB" id="325071at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="1 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="3">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="695"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="974"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1142" mass="126802" checksum="961C6F7F1DD2DE1B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X35</accession>
    <name>Q39X35_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Zinc protease PmbA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0947</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase U62 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514430.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0947"/>
    <dbReference type="EnsemblBacteria" id="ABB31189">
        <property type="protein sequence ID" value="ABB31189"/>
        <property type="gene ID" value="Gmet_0947"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0947"/>
    <dbReference type="eggNOG" id="COG0312">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026425_0_0_7"/>
    <dbReference type="OMA" id="YLYARAE"/>
    <dbReference type="OrthoDB" id="958356at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045569">
        <property type="entry name" value="Metalloprtase-TldD/E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045570">
        <property type="entry name" value="Metalloprtase-TldD/E_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002510">
        <property type="entry name" value="Metalloprtase-TldD/E_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035068">
        <property type="entry name" value="TldD/PmbA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036059">
        <property type="entry name" value="TldD/PmbA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01523">
        <property type="entry name" value="PmbA_TldD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19289">
        <property type="entry name" value="PmbA_TldD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19290">
        <property type="entry name" value="PmbA_TldD_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111283">
        <property type="entry name" value="SSF111283"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PmbA_TldD" evidence="2">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_M" evidence="4">
        <location>
            <begin position="114"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="PmbA_TldD_C" evidence="3">
        <location>
            <begin position="226"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="445" mass="46816" checksum="4ECB55B36CB26652" modified="2005-11-22" version="1">MNTNEMIETVATLLKDRPLDGWEVAAATSRLLSIEVKEQKVDTFKCSAPGGVSIRVLKNGGMGFSYSTSMEPADLARMVENALVGAGAQTPDEHHAFPEPRPGSEIPGLYDEGLAAVPEAEKVARAMELERLVMAADPRVKRVRKCSFGESTVETRIVNSRGVDATCRGTSVSASVSAIAEESGNSQMGWDFDFANHFTDLSVDRIATRAVAKAVGLLGAAKIPTMRCPAVLDNYVATEILEVLASAFLAESVQKGKSLLVGKKGTRIVSPLLRIRDDGTLPGGMGTAPFDAEGVPKQNTILVEDGVLRGYLYDTLRARKDGVASTGNASRGGIKSPPHMGVSNLFIENGTVPFDDLMAGIGRGILLTDVMGMHTANPISGDFSVGAAGFLIEEGKVTVPVKGIAISGNILELFQGVEGVGNDLRLYGTVGAPSLRIAALDVSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X81</accession>
    <name>Q39X81_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix transcriptional regulator PuuR, cupin domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">puuR</name>
        <name evidence="2" type="ordered locus">Gmet_0901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513931.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0901"/>
    <dbReference type="EnsemblBacteria" id="ABB31143">
        <property type="protein sequence ID" value="ABB31143"/>
        <property type="gene ID" value="Gmet_0901"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0901"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_1_4_7"/>
    <dbReference type="OMA" id="ESHYSHE"/>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="181" mass="20335" checksum="6ED10CE2CF1650FC" modified="2005-11-22" version="1">MKIGERLKRLRMINSLTQEELANRADLTKGYISQLENDATSPSIATLKDILDVFGVSMQEFFSDPIGEDVVYGKDARVQPSADDAAVTVELLVPGAQNREMDPALVTLAPGEEMDEQNFHEGEEFGFVLLGKIQLRLDDKIYTVKKDECFYFTSDKRHTVKNIGKGSARILWVVTPPTFDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XD9</accession>
    <name>Q39XD9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-methylpimelyl-(Acyl carrier protein) methylesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bioH</name>
        <name evidence="2" type="ordered locus">Gmet_0843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512987.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0843"/>
    <dbReference type="ESTHER" id="geomg-q39xd9">
        <property type="family name" value="BioH"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31085">
        <property type="protein sequence ID" value="ABB31085"/>
        <property type="gene ID" value="Gmet_0843"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0843"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_50_2_7"/>
    <dbReference type="OMA" id="DMWEYQM"/>
    <dbReference type="OrthoDB" id="1282004at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="22"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="272" mass="29594" checksum="3D343B2047028D3C" modified="2005-11-22" version="1">MPFVETAQKVTIHYEDEGSGFPLVFVHGWAMSGKVWAFQKPLADHFRLITLDLRGHGKSSAAPGYAFSDFAADLAALFDRLGLERAALVGWSLGAQVALEAVPLLEDRVAALVLVAGTPKFTTADGWPHGLPPHEARGLGLRLKRAYDATLGDFFRQMFAEGELSHDQYQRIVREIVIPRHLPDPGAVQACLVTLAGGDHRNLLPAIAAPTLVIHGDRDAICSPSAGRYLAEGIPGARFLSLEGTGHAPFLSQPERFNQELSRFLTEVIDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XJ1</accession>
    <name>Q39XJ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513536.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0791"/>
    <dbReference type="EnsemblBacteria" id="ABB31033">
        <property type="protein sequence ID" value="ABB31033"/>
        <property type="gene ID" value="Gmet_0791"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0791"/>
    <dbReference type="HOGENOM" id="CLU_1553089_0_0_7"/>
    <dbReference type="OrthoDB" id="1104553at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025748">
        <property type="entry name" value="PrcB_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14343">
        <property type="entry name" value="PrcB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223595" evidence="1">
        <location>
            <begin position="24"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="PrcB_C" evidence="2">
        <location>
            <begin position="99"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="172" mass="18515" checksum="5BECFFF04A08F88D" modified="2005-11-22" version="1">MNSIRTSLLLVLTVISLAGCATAIPVQPPPAAIKVPVETVAKGVGGAYSEPGTDTQLVWPQIRVISDQGGFTAFWNSLHRNVTPPPPLPSVDFSRNDVIAVVDMVRPTGGYGIEVKEAQEGMDAIWLTIIRRTPGRGCFTAQSLSQPYHLVAIRKSGKRCIPNYVDVTYSCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XJ8</accession>
    <name>Q39XJ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Organic solvent tolerance ABC transporter, periplasmic substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513529.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0784"/>
    <dbReference type="DNASU" id="3739347"/>
    <dbReference type="EnsemblBacteria" id="ABB31026">
        <property type="protein sequence ID" value="ABB31026"/>
        <property type="gene ID" value="Gmet_0784"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0784"/>
    <dbReference type="eggNOG" id="COG2854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094502_2_0_7"/>
    <dbReference type="OMA" id="MMGAWLI"/>
    <dbReference type="OrthoDB" id="1716096at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008869">
        <property type="entry name" value="MlaC/ttg2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042245">
        <property type="entry name" value="Tgt2/MlaC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36573">
        <property type="entry name" value="PTHR36573"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05494">
        <property type="entry name" value="MlaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004649">
        <property type="entry name" value="MlaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223402" evidence="1">
        <location>
            <begin position="22"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="200" mass="23099" checksum="1761A827A055A53C" modified="2005-11-22" version="1">MKWFALPILFITLALGGPVFAQGSPTQTVKKTVDEVVRIVSDKEMKKPQNEKKRRQELKKAIGAVFDYGEMAQRAMARNWRDRSAAEKKEFVSLFETLLENSYADKIESYNQEKIVYLNERIEGEYAEVRSKVVTAKRDEYSLDYRLMNKGGRWMAYDVVIEGVSLVSNYRGQFNKIITNEGYPALLKKLRSKRAEIKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XK4</accession>
    <name>Q39XK4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver CheY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY-11</name>
        <name evidence="3" type="ordered locus">Gmet_0778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513523.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0778"/>
    <dbReference type="EnsemblBacteria" id="ABB31020">
        <property type="protein sequence ID" value="ABB31020"/>
        <property type="gene ID" value="Gmet_0778"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0778"/>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_12_7"/>
    <dbReference type="OMA" id="TIERCHA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="142" mass="15986" checksum="1F486238393E87E3" modified="2005-11-22" version="1">MEPARNPAKSINILFVEDDRYARELIPLMISNKFPGVAIILADNGESGLELCRANEFDIVITDINMPDMDGIRMAGEIRGLKPDAKIIVMSGYSEKCYFDQLQDIGITDYILKPVDTKLLFLAIGKFIDQVMLKRHRPAVIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XM9</accession>
    <name>Q39XM9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513498.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0753"/>
    <dbReference type="EnsemblBacteria" id="ABB30995">
        <property type="protein sequence ID" value="ABB30995"/>
        <property type="gene ID" value="Gmet_0753"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0753"/>
    <dbReference type="eggNOG" id="COG3071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181383_0_0_7"/>
    <dbReference type="OMA" id="FYFPITT"/>
    <dbReference type="OrthoDB" id="2032133at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021320">
        <property type="entry name" value="DUF2905"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36443">
        <property type="entry name" value="PTHR36443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11146">
        <property type="entry name" value="DUF2905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="70" mass="7734" checksum="460BED3484BA7C2B" modified="2005-11-22" version="1">MQGLGKSLIVFGLIIAAIGVALTFAGKIPWLGRLPGDIYVKRDNFTFYFPLATSILISVILSLILWLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XT6</accession>
    <name>Q39XT6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gnfK</name>
        <name evidence="5" type="ordered locus">Gmet_0696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514087.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0696"/>
    <dbReference type="EnsemblBacteria" id="ABB30938">
        <property type="protein sequence ID" value="ABB30938"/>
        <property type="gene ID" value="Gmet_0696"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0696"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_1_7"/>
    <dbReference type="OMA" id="CTVALEW"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="248" mass="26862" checksum="DAC36510007B4622" modified="2005-11-22" version="1">MADALAKYLPDNGNVEGELLELLAFNEKMAELGRMAAGVVHELNTPLSVIVSATQMILREEELPEFVREMVERVNEEAHRLAELTKGVLSFARRDSGGRAEADANQVIGEVMTFLRFEAGKRSIGVIEDLDHRLPFIAADANRVKQVIINLVMNAFQAMGEGGTLFLRTVQESETAVTVQVADTGPGIPPDAQERIFTPFFTTKEPGEGTGLGLFITRKLMEGIGGAIAVKSVVGEGTTFTLTFPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XX1</accession>
    <name>Q39XX1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbamoyl-phosphate synthase large chain</fullName>
            <ecNumber evidence="13">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Carbamoyl-phosphate synthetase ammonia chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">carB-2</name>
        <name evidence="13" type="synonym">carB</name>
        <name evidence="17" type="ordered locus">Gmet_0661</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>2 ATP + H2O + hydrogencarbonate + L-glutamine = 2 ADP + carbamoyl phosphate + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 4 Mg(2+) or Mn(2+) ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.5" evidence="13"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514269.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0661"/>
    <dbReference type="EnsemblBacteria" id="ABB30903">
        <property type="protein sequence ID" value="ABB30903"/>
        <property type="gene ID" value="Gmet_0661"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0661"/>
    <dbReference type="eggNOG" id="COG0458">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000513_1_3_7"/>
    <dbReference type="OMA" id="VIKFARW"/>
    <dbReference type="OrthoDB" id="48855at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00171"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01424">
        <property type="entry name" value="MGS_CPS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01210_B">
        <property type="entry name" value="CPSase_L_chain_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CarbamoylP_synth_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CbamoylP_synth_lsu_CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033937">
        <property type="entry name" value="MGS_CPS_CarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="SSF48108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="SSF52335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="133"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="15">
        <location>
            <begin position="671"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="16">
        <location>
            <begin position="928"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="region of interest" description="Carboxyphosphate synthetic domain" evidence="13">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric domain" evidence="13">
        <location>
            <begin position="928"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="821"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="833"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="835"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB30903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1066" mass="116373" checksum="9361D4CFE2CC8D87" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y07</accession>
    <name>RS10_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsJ</name>
        <name type="ordered locus">Gmet_0625</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the binding of tRNA to the ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514236.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y07"/>
    <dbReference type="SMR" id="Q39Y07"/>
    <dbReference type="STRING" id="269799.Gmet_0625"/>
    <dbReference type="EnsemblBacteria" id="ABB30867">
        <property type="protein sequence ID" value="ABB30867"/>
        <property type="gene ID" value="Gmet_0625"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0625"/>
    <dbReference type="eggNOG" id="COG0051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122625_1_3_7"/>
    <dbReference type="OMA" id="QFEIRVH"/>
    <dbReference type="OrthoDB" id="2012682at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018268">
        <property type="entry name" value="Ribosomal_S10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_S10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_S10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="PTHR11700"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="SSF54999"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01049">
        <property type="entry name" value="rpsJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00361">
        <property type="entry name" value="RIBOSOMAL_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000237048" description="30S ribosomal protein S10">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00508"/>
        </source>
    </evidence>
    <sequence length="102" mass="11510" checksum="4C6EF05FED413A16" modified="2005-11-22" version="1">MPSQKIRIRLKAFDHKLLDQSVGEIVDTAKRTGARVAGPIPLPTIINKYCVLRGPHVDKKSREQFEIRTHKRLIDILDPTQQTVDALMKLDLSAGVDVEIKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y08</accession>
    <name>EFTU_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor Tu</fullName>
            <shortName evidence="2">EF-Tu</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tuf1</name>
        <name type="ordered locus">Gmet_0611</name>
    </gene>
    <gene>
        <name evidence="2" type="primary">tuf2</name>
        <name type="ordered locus">Gmet_0624</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365695.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y08"/>
    <dbReference type="SMR" id="Q39Y08"/>
    <dbReference type="STRING" id="269799.Gmet_0611"/>
    <dbReference type="PRIDE" id="Q39Y08"/>
    <dbReference type="EnsemblBacteria" id="ABB30853">
        <property type="protein sequence ID" value="ABB30853"/>
        <property type="gene ID" value="Gmet_0611"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30866">
        <property type="protein sequence ID" value="ABB30866"/>
        <property type="gene ID" value="Gmet_0624"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0611"/>
    <dbReference type="KEGG" id="gme:Gmet_0624"/>
    <dbReference type="eggNOG" id="COG0050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_0_0_7"/>
    <dbReference type="OMA" id="EGDKEWG"/>
    <dbReference type="OrthoDB" id="621774at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000337394" description="Elongation factor Tu">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="60"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="174"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="136"/>
            <end position="139"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00118"/>
        </source>
    </evidence>
    <sequence length="396" mass="43207" checksum="6F444F9695FED0AE" modified="2005-11-22" version="1">MAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITRVLAERGQAEFKGFDQIDNAPEERERGITIATSHVEYETEKRHYAHVDCPGHADYVKNMITGAAQMDGAILVVSAADGPMPQTREHILLARQVGVPYIVVFLNKADMVDDEELLELVELEIRELLSSYDFPGDDIPIIKGSALKALNGDKDELGSEAIVKLMDAVDAYIPEPERAIDKPFLMPVEDVFSISGRGTVATGRVERGVVKVGEEVEIVGIKTTTKTTVTGVEMFRKLLDEGRAGDNIGALLRGVKREDIERGQVLARPGSITPHTKFKAEAYILTKEEGGRHTPFFNGYRPQFYFRTTDVTGIVDLPAGTEMVMPGDNVAVTVNLITPIAMDEGLRFAIREGGRTVGAGVVSSIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y73</accession>
    <name>Q39Y73_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">omcO</name>
        <name evidence="2" type="ordered locus">Gmet_0558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512255.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0558"/>
    <dbReference type="EnsemblBacteria" id="ABB30801">
        <property type="protein sequence ID" value="ABB30801"/>
        <property type="gene ID" value="Gmet_0558"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0558"/>
    <dbReference type="HOGENOM" id="CLU_291837_0_0_7"/>
    <dbReference type="OMA" id="QGFSANC"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010176">
        <property type="entry name" value="C4xCH_C2xCH_motif_GEOSU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09698">
        <property type="entry name" value="GSu_C4xC__C2xCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01904">
        <property type="entry name" value="GSu_C4xC__C2xCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223434" evidence="1">
        <location>
            <begin position="25"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1036" mass="108933" checksum="3FE497DF1A9A3F52" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y76</accession>
    <name>Q39Y76_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512252.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0555"/>
    <dbReference type="EnsemblBacteria" id="ABB30798">
        <property type="protein sequence ID" value="ABB30798"/>
        <property type="gene ID" value="Gmet_0555"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0555"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="EMELIHQ"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="144"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="457" mass="51780" checksum="53752A40B563E693" modified="2005-11-22" version="1">MRKTKILVVDDEHLIRWSLEQNLKKQGYEVVSAGNGEDALRLVRDEQPDLVLLDIQLPGISGLDVLEKIKEHDEEIIVIMVTAHGALETAVHAMRLGAFDYINKPFNLDEMAIVIRKALETSDLRREVQRLRGEQAKKFGTPDIIGASRHMKNVLDMMEKVAKSDASTVLVQGESGTGKELVAKWIHYKSARAERPFVAINCAAVPATLLESELFGHEKGAFTDAKAMKKGLFELADGGTVFLDEIGDMELGMQAKLLRFLEERTFRRIGGTKSFSVDVRIISATNRDLIKAIEEKSFRNDLYYRLQVIPIYLPPLRERREDILTLTSHFIELFNAEFNKHVTGISKMAEKLLLDYTWPGNIRELKNVIERAIILGNDETLLLEHLPLEIVAKASSQSVGLTTFKLPPEGIDIEEVEKELIRQALEISDWNQSKAARKLNLGIDAFRYRMKKFGYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YJ9</accession>
    <name>Q39YJ9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagella basal body P-ring formation protein FlgA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">flgA</name>
        <name evidence="6" type="ordered locus">Gmet_0432</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FlgA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512404.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0432"/>
    <dbReference type="EnsemblBacteria" id="ABB30675">
        <property type="protein sequence ID" value="ABB30675"/>
        <property type="gene ID" value="Gmet_0432"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0432"/>
    <dbReference type="eggNOG" id="COG1261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070510_3_0_7"/>
    <dbReference type="OMA" id="RYEIQVN"/>
    <dbReference type="OrthoDB" id="1518992at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006190">
        <property type="entry name" value="AFP_Neu5c_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036732">
        <property type="entry name" value="AFP_Neu5c_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017585">
        <property type="entry name" value="Flag_basal_body_FlgA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039246">
        <property type="entry name" value="Flagellar_FlgA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041231">
        <property type="entry name" value="FlgA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013974">
        <property type="entry name" value="SAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36307">
        <property type="entry name" value="PTHR36307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13144">
        <property type="entry name" value="ChapFlgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17656">
        <property type="entry name" value="ChapFlgA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00858">
        <property type="entry name" value="SAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51269">
        <property type="entry name" value="SSF51269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03170">
        <property type="entry name" value="flgA_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50844">
        <property type="entry name" value="AFP_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="3 4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005143157" description="Flagella basal body P-ring formation protein FlgA" evidence="4">
        <location>
            <begin position="21"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="AFP-like" evidence="5">
        <location>
            <begin position="113"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="236" mass="25290" checksum="28C86E3797EA0A9F" modified="2005-11-22" version="1">MRLAAVIAVLVLVVGTAAFAAPAFQTISNARVKAAIAEFVRQKTDGLGMETTLKRIGFQGDLKVPVGEVSFEVAAPNRWEGWGKANLAVIVRVNDRVERNISVPVEVEALGDTVVVLRALERGDVIGAADVTVQRRDLSTLTGRVYRSADEVIGKRARMPVRANMPLRGDQLEKVPLVKSGQLVTILVENQAMRLTATGKARGNGAEGDIVMVQNLGSLKEVPARVIDAGTVQVDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YP0</accession>
    <name>RS21_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsU</name>
        <name type="ordered locus">Gmet_0391</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512363.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YP0"/>
    <dbReference type="SMR" id="Q39YP0"/>
    <dbReference type="STRING" id="269799.Gmet_0391"/>
    <dbReference type="DNASU" id="3739369"/>
    <dbReference type="EnsemblBacteria" id="ABB30634">
        <property type="protein sequence ID" value="ABB30634"/>
        <property type="gene ID" value="Gmet_0391"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0391"/>
    <dbReference type="eggNOG" id="COG0828">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159258_1_2_7"/>
    <dbReference type="OMA" id="FKRSCQK"/>
    <dbReference type="OrthoDB" id="2088764at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00358">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_S21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038380">
        <property type="entry name" value="S21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21109">
        <property type="entry name" value="PTHR21109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00976">
        <property type="entry name" value="RIBOSOMALS21"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00030">
        <property type="entry name" value="S21p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000266680" description="30S ribosomal protein S21">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00358"/>
        </source>
    </evidence>
    <sequence length="65" mass="7657" checksum="168F5FAEE02798D0" modified="2005-11-22" version="1">MPGVKVKEAEPFELALKKFKKQCEKAGILSEVRKREHYEKPSIKKKKKAIAARKRAMKKQRKMMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YZ1</accession>
    <name>Q39YZ1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4150 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0288</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513999.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0288"/>
    <dbReference type="EnsemblBacteria" id="ABB30533">
        <property type="protein sequence ID" value="ABB30533"/>
        <property type="gene ID" value="Gmet_0288"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0288"/>
    <dbReference type="eggNOG" id="COG1196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1169330_0_0_7"/>
    <dbReference type="OMA" id="CRRLDPM"/>
    <dbReference type="OrthoDB" id="2045896at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025425">
        <property type="entry name" value="Tox_PAAR-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13665">
        <property type="entry name" value="DUF4150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4150" evidence="2">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="237" mass="24850" checksum="52658B617375C373" modified="2005-11-22" version="1">MSATVIVNGQTVVHKDSGGVLTTGPDVCLTPMGPSVVPIPYTNIAVSADTSQGSTSVAMDSNPIMLKGSVFSKSTGDEPGKVGGVSSGITKGKAKFVNYSSDVFADGKPVCRRLDPMVSNLSAAGNTPPAPLQQGNARARGKQAQGHLLSVALVFEHPDVVTGRTTQPLVDLKYSLNGPKTITVAKSEPYTGIQEYVPQGGYALEFDRNDLKEKLTERSVSEKQSSKGAAFRNHKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z51</accession>
    <name>Q39Z51_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512819.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0228"/>
    <dbReference type="EnsemblBacteria" id="ABB30473">
        <property type="protein sequence ID" value="ABB30473"/>
        <property type="gene ID" value="Gmet_0228"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0228"/>
    <dbReference type="eggNOG" id="COG0428">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015114_7_0_7"/>
    <dbReference type="OMA" id="MLLTEWF"/>
    <dbReference type="OrthoDB" id="2030075at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="239" mass="24884" checksum="197AD1389D4A1CB0" modified="2005-11-22" version="1">MTLHNLLLISIPAVVALCGGFLAAFWKPNHQSRSLIQHFAAGVVLAALAVELLPEIGREHAPGPVLIGAFALGSLFMYGLKFWTEHLEHQDQLAGIRAGIGRGLLLATFIDVAVDGFIIGAGFAAGGETGPILAIGLSVELLFLGLALTSDQVSDRQIVLVSGGLGVTVLLCAVLGNILLAGASHTAIGAALAFSAAALLYLVTEELLMEAHVVQEKPISTLVLFAGFLTFWSIQLMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z53</accession>
    <name>Q39Z53_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512816.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0226"/>
    <dbReference type="EnsemblBacteria" id="ABB30471">
        <property type="protein sequence ID" value="ABB30471"/>
        <property type="gene ID" value="Gmet_0226"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0226"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_13_3_7"/>
    <dbReference type="OMA" id="DSWRWEW"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="218" mass="23938" checksum="5762914DC3FD70CE" modified="2005-11-22" version="1">MFEGIFWDNDGVLMETEHLYYQANAEALAQAGVTLTLDDFRRISLRQGESVLGLAAGAGLGDEEATALRRVRDGIYYRLLGEEARVMSGVRETLARLHGRLPMAIVTSCRRENFLQMHRQSGLLDYFDFILTREDYGASKPDPEPYRTACSRVGLDPGRCLAIEDSERGVTSAARAGLVVAAIPGDMNRGGDFGAARWLLDGVRELPALLKLDEAQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z88</accession>
    <name>Q39Z88_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DoxX family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DoxX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512779.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0190"/>
    <dbReference type="EnsemblBacteria" id="ABB30436">
        <property type="protein sequence ID" value="ABB30436"/>
        <property type="gene ID" value="Gmet_0190"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0190"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058421_3_4_7"/>
    <dbReference type="OMA" id="NNGYEYA"/>
    <dbReference type="OrthoDB" id="2025630at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="145" mass="15220" checksum="3273CF74331C624B" modified="2005-11-22" version="1">MARSTMGATADSLALLMIRIPLGAIFIAHGSQKLLGLFGGHGLTATFATFEQKLGIPPILTLLAIIAEFGGGIGVLCGFLTRLSGFSIAATMAVAIYKVSWVNGFFLNGPRGDGIEYNLALLGMALSLVLIGGGAWSVDRYLFRR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-02-09" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZA5</accession>
    <name>NUON_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit N</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit N</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoN</name>
        <name type="ordered locus">Gmet_0172</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512760.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZA5"/>
    <dbReference type="SMR" id="Q39ZA5"/>
    <dbReference type="STRING" id="269799.Gmet_0172"/>
    <dbReference type="EnsemblBacteria" id="ABB30419">
        <property type="protein sequence ID" value="ABB30419"/>
        <property type="gene ID" value="Gmet_0172"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0172"/>
    <dbReference type="eggNOG" id="COG1007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_1_3_7"/>
    <dbReference type="OMA" id="YYLQWTA"/>
    <dbReference type="OrthoDB" id="1664448at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00445">
        <property type="entry name" value="NDH1_NuoN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010096">
        <property type="entry name" value="NADH-Q_OxRdtase_suN/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01770">
        <property type="entry name" value="NDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000391153" description="NADH-quinone oxidoreductase subunit N">
        <location>
            <begin position="1"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00445"/>
        </source>
    </evidence>
    <sequence length="466" mass="47872" checksum="AECA3BE6F13FE047" modified="2005-11-22" version="1">MTITELWALIPLLILACGSVFVLMLGAIVPGRCGTVIGVAVCAGTALWAMLAPPQPLAPPTLGVTVTPFTRFFLVFFAVTAGLSLLLARDHAARQGLKGEEYPATILFGTFGMGVVASAANFLTLFLGLEALTFAFYILVAYDHNRPASGEAGLKYLLMGAVSAAFVAFGIALLYGATGTLEISRAVAASAAGGGIALAGWGLLLAGLAFKISLAPAHLWTPDIYQGGPTPVVAFLASGSKGAAIALFLLILSPLGTLGTLRAPLWGLAFLSMTVGNLAALLQPNVKRMLAYSSVAQMGYVALALLSGGRGYEAAAFYAVAYGAMVLAAFGALASLEGETPLEQVDDLRGLGYHRPFQGVVLAVAMLALAGIPPTVGFVGKFAIFFAALKGGEAPLAVIGILTAAASAYYYLRVVVNLYMKPADETGSGQRPTVAEALSLGIAALAIFILGIWPGPLFDLAAAILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZB2</accession>
    <name>Q39ZB2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit J</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">nuoJ-2</name>
        <name evidence="2" type="ordered locus">Gmet_0165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 6 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512752.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0165"/>
    <dbReference type="EnsemblBacteria" id="ABB30412">
        <property type="protein sequence ID" value="ABB30412"/>
        <property type="gene ID" value="Gmet_0165"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0165"/>
    <dbReference type="eggNOG" id="COG0839">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085957_0_1_7"/>
    <dbReference type="OMA" id="CAITARQ"/>
    <dbReference type="OrthoDB" id="1683794at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001457">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042106">
        <property type="entry name" value="Nuo/plastoQ_OxRdtase_6_NuoJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00499">
        <property type="entry name" value="Oxidored_q3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0874">Quinone</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="161" mass="17232" checksum="053F382F40DAB4B2" modified="2005-11-22" version="1">MESALFYILAVVTVTGTAFAITEKHAVHAIVYLVTSFFALAVIFFLLGAPVVAIFEVIIYAGAIMVLFLFVIMMLDLGHPERARLPGIREWWPALALGAVTLASALALVVSRAPAIPAPGKAIGVKEFALALFGKYGVAVEVISMQLLFALVGALYLARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZF0</accession>
    <name>Q39ZF0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4130 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514130.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0125"/>
    <dbReference type="EnsemblBacteria" id="ABB30374">
        <property type="protein sequence ID" value="ABB30374"/>
        <property type="gene ID" value="Gmet_0125"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0125"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068835_1_0_7"/>
    <dbReference type="OMA" id="HVPKRYW"/>
    <dbReference type="OrthoDB" id="659732at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023875">
        <property type="entry name" value="DNA_metab_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025404">
        <property type="entry name" value="DUF4130"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13566">
        <property type="entry name" value="DUF4130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03915">
        <property type="entry name" value="SAM_7_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4130" evidence="1">
        <location>
            <begin position="82"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="248" mass="28804" checksum="CC37594D7D7121D1" modified="2005-11-22" version="1">MILRYDGTFAGFLTAVALARERSAEPEAITDREPEQQGLFAAVEEVETDRDRAGELYQLIRRTLPAGAVQTLRYAFHAGEPGREILLFRYLQLGLTTGPRFGAMLAHEAVIPVWKLARAVGREAHRYKGLVRFRQLEGDVWYAAMEPDHRILPLIAPHFAARFADQRWIIHDRRRNEAVAFDPARREWADIPLEVTGPLPLSAGEELFRDLWQRYFDRLSIAERHNPKLQRQNLPLKHRRHLPEFERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZN7</accession>
    <name>Q39ZN7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513804.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0037"/>
    <dbReference type="EnsemblBacteria" id="ABB30287">
        <property type="protein sequence ID" value="ABB30287"/>
        <property type="gene ID" value="Gmet_0037"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0037"/>
    <dbReference type="eggNOG" id="COG3794">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145254_0_0_7"/>
    <dbReference type="OMA" id="FAYYCTH"/>
    <dbReference type="OrthoDB" id="1654242at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223541" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="136" mass="14884" checksum="AE23A4B9A73CAA55" modified="2005-11-22" version="1">MKTTIAIVMMLAAGSLAAVAAQEEEKPYFATIGSDGIQHVEIVGGSYFFKPGHIVVKVNVPVELKVRKEAGMVPHNIAMNSPEAGIVFDVSLGEEPKIVKFTPVKTGRYSMYCDKKLLFFKSHREKGMEGVLEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZR8</accession>
    <name>Q39ZR8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30256.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365615.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0006"/>
    <dbReference type="EnsemblBacteria" id="ABB30256">
        <property type="protein sequence ID" value="ABB30256"/>
        <property type="gene ID" value="Gmet_0006"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0006"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039277_0_0_7"/>
    <dbReference type="OMA" id="GMRDAWG"/>
    <dbReference type="OrthoDB" id="803710at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30256.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="523" mass="58820" checksum="9D679388C90338E2" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2022-08-03" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>J7LWF3</accession>
    <name>J7LWF3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mutator family transposase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_3341</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Required for the transposition of the insertion element.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the transposase mutator family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3341"/>
    <dbReference type="EnsemblBacteria" id="AFR42855">
        <property type="protein sequence ID" value="AFR42855"/>
        <property type="gene ID" value="Gmet_3341"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3341"/>
    <dbReference type="eggNOG" id="COG3328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036805_12_0_7"/>
    <dbReference type="OMA" id="WISQNEG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001207">
        <property type="entry name" value="Transposase_mutator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33217">
        <property type="entry name" value="PTHR33217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00872">
        <property type="entry name" value="Transposase_mut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0814">Transposable element</keyword>
    <keyword evidence="4 6" id="KW-0815">Transposition</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="AFR42855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="402" mass="46011" checksum="E371E015A720021F" modified="2012-10-31" version="1">MEEHCTPKAQIIQLNETAVRDHLGEMVRSTVEETLNRMLDAEADRLCTAEKYQRNDARTDTRAGHYQRKLQTKAGEVTLNMPKLRRQTFETAIIERYRRREASVEEALIEMYLAGVSVRRVEDITETLWGTKVSPGTISNLNKKVYAKIEEWRNRPIKGEFPYVYLDGIVLKRSWGGEVTNVSVLVAIGVNDQGYRKILGVCEGAKEDKAGWSSFLRHLGLTGVRLFITDACMGLVESLAEFYPKTKWQRCTVHFYRNVFSVVPAKRMAEVAAMLKAIHASEDKKAALEKAEAVFAKLEAMKLKEAAKKVQESITETLSYYDFPREHRIRIRTNNALERIMKEIRRRTKVVGAFPDGNSALMLCAARLRHIAGTQWGTKRYLNIDLLREQELNQQLEEAEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>J7M0C3</accession>
    <name>J7M0C3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_A3641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="AFR42861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514728.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3641"/>
    <dbReference type="EnsemblBacteria" id="AFR42861">
        <property type="protein sequence ID" value="AFR42861"/>
        <property type="gene ID" value="Gmet_A3641"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3641"/>
    <dbReference type="HOGENOM" id="CLU_2769998_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="69" mass="7762" checksum="BB62C99CC41AEF76" modified="2012-10-31" version="1">MNGKERQTFITHLTSDHAEARKAYNAATEELRLVTWGKMLGLEAAASCAGMQTLHRDLADLRNRDCENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEL9</accession>
    <name>J9JEL9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512771.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFR42789">
        <property type="protein sequence ID" value="AFR42789"/>
        <property type="gene ID" value="Gmet_3578"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3578"/>
    <dbReference type="HOGENOM" id="CLU_2953944_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="59" mass="7025" checksum="D7B6701ABEBE7A47" modified="2012-10-31" version="1">MKEMARMVIKVIIWIFSAVLFGFPLIVFSVIDWILDKIAGESHDMDLRLDYWKPFERHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEM6</accession>
    <name>J9JEM6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3591</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3591"/>
    <dbReference type="EnsemblBacteria" id="AFR42806">
        <property type="protein sequence ID" value="AFR42806"/>
        <property type="gene ID" value="Gmet_3591"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3591"/>
    <dbReference type="HOGENOM" id="CLU_208450_0_0_7"/>
    <dbReference type="OMA" id="AACHKTF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="58" mass="6621" checksum="1BD32338EAAEC8F7" modified="2012-10-31" version="1">MNIKLLGDYYVWYCDWCDTRNLTLQQKFAVGVVSCGACHKHFDTTAREGEHFALCGGF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PT7</accession>
    <name>DNAK_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein DnaK</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">HSP70</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heat shock 70 kDa protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein 70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dnaK</name>
        <name type="ordered locus">Gmet_3532</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a chaperone.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">By stress conditions e.g. heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513688.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39PT7"/>
    <dbReference type="SMR" id="Q39PT7"/>
    <dbReference type="STRING" id="269799.Gmet_3532"/>
    <dbReference type="PRIDE" id="Q39PT7"/>
    <dbReference type="EnsemblBacteria" id="ABB33737">
        <property type="protein sequence ID" value="ABB33737"/>
        <property type="gene ID" value="Gmet_3532"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3532"/>
    <dbReference type="eggNOG" id="COG0443">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005965_2_0_7"/>
    <dbReference type="OMA" id="ISIKRHM"/>
    <dbReference type="OrthoDB" id="161217at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="PTHR19375"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="SSF100920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="SSF100934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_1000059567" description="Chaperone protein DnaK">
        <location>
            <begin position="1"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphothreonine; by autocatalysis" evidence="1">
        <location>
            <position position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="638" mass="68479" checksum="C5392664FD5165D3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q50</accession>
    <name>Q39Q50_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ParB-like nuclease domain protein, putative transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3412</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in chromosome partition. Localize to both poles of the predivisional cell following completion of DNA replication. Binds to the DNA origin of replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ParB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514219.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3412"/>
    <dbReference type="EnsemblBacteria" id="ABB33624">
        <property type="protein sequence ID" value="ABB33624"/>
        <property type="gene ID" value="Gmet_3412"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3412"/>
    <dbReference type="eggNOG" id="COG1475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023853_0_0_7"/>
    <dbReference type="OMA" id="IALSYQR"/>
    <dbReference type="OrthoDB" id="653368at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041468">
        <property type="entry name" value="HTH_ParB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004437">
        <property type="entry name" value="ParB/RepB/Spo0J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003115">
        <property type="entry name" value="ParB/Sulfiredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036086">
        <property type="entry name" value="ParB/Sulfiredoxin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17762">
        <property type="entry name" value="HTH_ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02195">
        <property type="entry name" value="ParBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00470">
        <property type="entry name" value="ParB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110849">
        <property type="entry name" value="SSF110849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00180">
        <property type="entry name" value="parB_part"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ParB" evidence="4">
        <location>
            <begin position="26"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="279" mass="31369" checksum="F95E822E3E67123C" modified="2005-11-22" version="1">MVRKTGLGKGMAALLPVVEEEGKRYFSCPIEEIRPNRNQPRKTFTPDRLEELAASIREKGIIQPLVVRKKGDHYELIAGERRWRAAQKAGLREVPVVIQDVSEDTALEMALIENIQREDLNAVEEAEAYHALMENFSLTQDELAKRVGKDRSTVANSLRLLKLPAELKKDIVEERLAMGHARAILALDTDLQMREARDAVVKGNLTVREAESLVKRLKGEQKPKPKVATVEVHAADLVEQLRRRFMTKIAVRKSGKGGKIEIAYGSRDELARIVDLLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q69</accession>
    <name>Q39Q69_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Menaquinone biosynthesis polyprenyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_3393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512619.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3393"/>
    <dbReference type="EnsemblBacteria" id="ABB33605">
        <property type="protein sequence ID" value="ABB33605"/>
        <property type="gene ID" value="Gmet_3393"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3393"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034879_5_1_7"/>
    <dbReference type="OMA" id="LVMFSHT"/>
    <dbReference type="OrthoDB" id="1472516at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006371">
        <property type="entry name" value="HB_polyprenyl-transferase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01475">
        <property type="entry name" value="ubiA_other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="298" mass="32097" checksum="E6BDC4C1F4C6C7C3" modified="2005-11-22" version="1">MVSEERMAMGMFGKIKVFLEMIKFSHTVFALPFAFTGAVLAARGVPTAYQVFWILMAMVGARTAAMGMNRVIDAEIDARNPRTAGRAIPAGLIGKGTAVAFIVISILLMLYAAYRLNPLCLYLSPVALFFLVLYSYCKRFTALAHVVLGICLAAAPLGAWIAIRGTVELPAVLLGLAVLFWVAGFDILYALQDLEFDKGAGLHSIPSRLGVNGSLWTARLFHVAMAALLAGLYVSAGLGVWYLAGLGLCVTMLLYEHWLLRGGDLSRLDAAFFAMNGYISITLFVATFVDVLARKGGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QA6</accession>
    <name>GSA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate-1-semialdehyde 2,1-aminomutase</fullName>
            <shortName evidence="1">GSA</shortName>
            <ecNumber evidence="1">5.4.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate-1-semialdehyde aminotransferase</fullName>
            <shortName evidence="1">GSA-AT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemL</name>
        <name type="ordered locus">Gmet_3356</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-4-amino-5-oxopentanoate = 5-aminolevulinate</text>
            <dbReference type="Rhea" id="RHEA:14265"/>
            <dbReference type="ChEBI" id="CHEBI:57501"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="5.4.3.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.3.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512582.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QA6"/>
    <dbReference type="SMR" id="Q39QA6"/>
    <dbReference type="STRING" id="269799.Gmet_3356"/>
    <dbReference type="EnsemblBacteria" id="ABB33568">
        <property type="protein sequence ID" value="ABB33568"/>
        <property type="gene ID" value="Gmet_3356"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3356"/>
    <dbReference type="eggNOG" id="COG0001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_1_5_7"/>
    <dbReference type="OMA" id="WGPLIFG"/>
    <dbReference type="OrthoDB" id="493793at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00317"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042286">
        <property type="term" value="F:glutamate-1-semialdehyde 2,1-aminomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00375">
        <property type="entry name" value="HemL_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004639">
        <property type="entry name" value="4pyrrol_synth_GluAld_NH2Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00713">
        <property type="entry name" value="hemL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000243575" description="Glutamate-1-semialdehyde 2,1-aminomutase">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00375"/>
        </source>
    </evidence>
    <sequence length="427" mass="45479" checksum="0EEF1BBE815FB266" modified="2005-11-22" version="1">MNTSHSKELFAKAQEIIPGGVNSPVRAFKSVGAEPVFIKKASGSTIIDADDNAYIDYVGSWGPMILGHCHPRIVASVQRATENGSSFGAPTELEITLAEMVVAAVPSIEMVRMVSSGTEATMSAIRLARGYTGRDKIIKFSGCYHGHADSLLVKAGSGAATFGVPDSPGVPRDFAQHTLTATFNDLESVEELICAHSREVACIIVEPIAGNMGTVPPRAGFLEGLREICTNEGIILIFDEVMTGFRVAYGGAQERYGITPDMTTLGKIIGGGLPVGAFGGKREIMQQLSPSGGVYQAGTLSGNPLAMTAGIETLKLLQEDGFYGRLEEKSRALAEGIADAARRAGYPIYSTRVGSMFCAFFTNGEVHDWTSAAMCDTKSFATFFRSMLEEGIYLAPSQFETAFVSIAHSSEDIEKTIAAAFSCFKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QE4</accession>
    <name>Q39QE4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Scaffold protein CheW associated with MCPs of classes 40H and 40+24H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mvhQ</name>
        <name evidence="2" type="ordered locus">Gmet_3317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512541.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3317"/>
    <dbReference type="EnsemblBacteria" id="ABB33530">
        <property type="protein sequence ID" value="ABB33530"/>
        <property type="gene ID" value="Gmet_3317"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3317"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_1_7"/>
    <dbReference type="OMA" id="CVNIMSV"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="17"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="166" mass="17663" checksum="6D656FC68C0AA8EA" modified="2005-11-22" version="1">MTSLPTLAKGRSAAGKPLHLVGFRVGNEEYCFEILTVQEIIRIVPITAVPDAPEHVEGIINLRGRIVPIIDFRRRFRITGERTVDEADRVIVVTGTGNATVGFIVDGVSQVMKLPAEDLSPAPAGGAGCDAEAIRGVGNVGDRLVIVLDLDKMFSADELTTLTGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QF1</accession>
    <name>Q39QF1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VI secretion system outer membrane lipoprotein TssJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tssJ</name>
        <name evidence="2" type="ordered locus">Gmet_3310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512534.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3310"/>
    <dbReference type="EnsemblBacteria" id="ABB33523">
        <property type="protein sequence ID" value="ABB33523"/>
        <property type="gene ID" value="Gmet_3310"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3310"/>
    <dbReference type="eggNOG" id="COG3521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102939_2_0_7"/>
    <dbReference type="OMA" id="VAGYYPF"/>
    <dbReference type="OrthoDB" id="1267591at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017734">
        <property type="entry name" value="T6SS_SciN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038706">
        <property type="entry name" value="Type_VI_SciN-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12790">
        <property type="entry name" value="T6SS-SciN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03352">
        <property type="entry name" value="VI_chp_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223146" evidence="1">
        <location>
            <begin position="27"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="184" mass="20537" checksum="BD63F7137443AD31" modified="2005-11-22" version="1">MKRRAALLLYVSAIASLCSCTSTPKATPPLDWGYEKEAISVTLKGDPQLNLFQKSPHALVACLYQLRDPNAFNQFRTEPDGLTKLLECGRFDPGVATAKRMVIQPGQEVNESLDRAEGARYVGFVAGYYRLDKDRSARLYTIPSVEETKGFLSRTKLVKPGRLDMKLLLGPQEIQDVTEETEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QF2</accession>
    <name>Q39QF2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3309</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512533.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3309"/>
    <dbReference type="EnsemblBacteria" id="ABB33522">
        <property type="protein sequence ID" value="ABB33522"/>
        <property type="gene ID" value="Gmet_3309"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3309"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_7_1_7"/>
    <dbReference type="OMA" id="GSKRENG"/>
    <dbReference type="OrthoDB" id="1308416at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="153" mass="16753" checksum="A2C14A404BDD5DB9" modified="2005-11-22" version="1">MSTHDSPVHIVVVGCLIRNGLGEILLIRHHKRGWEIPQGRVEAGEGIVDALRREVREETGVEIKPGPLTAVWSKVSPPASLILTFLADYAEGELAPSDETPELGWFSEREGVELVAHPVTRDRLRALLDYSGTVACFSYATNPYKLLGSLGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QH5</accession>
    <name>Q39QH5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512509.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3286"/>
    <dbReference type="DNASU" id="3741007"/>
    <dbReference type="EnsemblBacteria" id="ABB33499">
        <property type="protein sequence ID" value="ABB33499"/>
        <property type="gene ID" value="Gmet_3286"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3286"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_6_0_7"/>
    <dbReference type="OMA" id="PAYCSDC"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="72"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="251" mass="27085" checksum="494B4181526DE69D" modified="2005-11-22" version="1">MKQDLSLHQTGSVEHVIALLETLTEDTPIHSVATISSRLGISRNKAFRLLATLESRELVEKDKHGSYRLGTAAADLARRLLDNVNIIGHARPVLNELARRHGEAVYLSVLKDDDVIFLDVADCAGVEGSGSLVGKRFPSLATSAGKAIRSLQSRDLLEKLLGGKRGRQRSVDLEAIIGELEVIRKHGVAIDEGGGTSSAATAVRDYTGKIVCALTVLGPSVRMLRDRIEKEIAPSLMEGAEVLSLRFGYAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QJ3</accession>
    <name>Q39QJ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase, HDOD domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512705.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3268"/>
    <dbReference type="EnsemblBacteria" id="ABB33481">
        <property type="protein sequence ID" value="ABB33481"/>
        <property type="gene ID" value="Gmet_3268"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3268"/>
    <dbReference type="eggNOG" id="COG1639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048246_4_0_7"/>
    <dbReference type="OMA" id="ANSARFH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="20"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="297" mass="33446" checksum="6E0286D7861F1FFE" modified="2005-11-22" version="1">MEQLSKMEKAAALIRGMTDLPTIPAVATQVLSLLDQPDVEIDQVAELLLTDQVMAARVLKMVNSPLYRPATVITSLKGALVYLGLRHIREFILTCSFIQSFEGKEGVLGVKPFWEHSFGVGIVARLIAAKVGYHDTEKAYIGGLIHDIGEVFLSYYLKDKFQKVVDAIRESPVQLVEAEERILGTTHCEVGLCLAREWHFPDDYCEIVACHHAPREATNAPRLVAIVNLADLFCTVRNLDYGGKEWTSFSLADEPAWAMIQEQGKKLAEFDVERFCYELDDQVEEIRELVTNIFKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QL8</accession>
    <name>Q39QL8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rubredoxin:oxygen/nitric oxide oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">roo</name>
        <name evidence="7" type="ordered locus">Gmet_3243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512681.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3243"/>
    <dbReference type="EnsemblBacteria" id="ABB33456">
        <property type="protein sequence ID" value="ABB33456"/>
        <property type="gene ID" value="Gmet_3243"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3243"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017490_0_0_7"/>
    <dbReference type="OMA" id="HVKNNIH"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016440">
        <property type="entry name" value="Rubredoxin-O_OxRdtase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005243">
        <property type="entry name" value="ROO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="6">
        <location>
            <begin position="256"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="404" mass="45574" checksum="F6A2A69DC90829BF" modified="2005-11-22" version="1">MKAVEIKKDIYWVGAVDWAVRDFHGYETPRGTTYNNYLIMDDEITLIDTVKYDFATYTLKNISGVVDPARIKNVIINHIENDHVTSLDCVMDLAPNATIYISEKGKKGLERFFDLSRWNVKTVKTGDTLTIGKRTLEFLETPMLHWPDSMVTYAREDKILFTQDAFGQHVASANRFDDEYEISNSPVELEDAVVDYYANILMPFGQMIKTKIAEIQAKGFEIDIIAPDHGLIWRKDPGKVLGMYLDMANGKARESVAIIYDTMWQSTEKMAGPIAEGVRAEGLNCQIIKLRATPTSVAIKEFWKCRGALIGSPTLNNILFPSVAEFLTHLRGLRPKNRIVGAFGSFGWGGGAVKESYEVFKQMGLQTVEPGIQLAYRPSLADEEACFEFGRTFARQVSEYHKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QN2</accession>
    <name>Q39QN2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-related protein disulfide reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512668.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3229"/>
    <dbReference type="EnsemblBacteria" id="ABB33442">
        <property type="protein sequence ID" value="ABB33442"/>
        <property type="gene ID" value="Gmet_3229"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3229"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_0_7"/>
    <dbReference type="OMA" id="WLVINYW"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223265" evidence="1">
        <location>
            <begin position="27"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="170" mass="18322" checksum="B8DE55F8AEF23EFE" modified="2005-11-22" version="1">MRIVPVLRAFVAAAGFTMAVASPSLAIPQKGQPAPPLKVVSTSGQQISLANYKGYVLVIDFFATWCPPCREAIPHLNGISRKYGRQGLQVLGLSLDDGDEGAVKDFIASKRIVYPVALAGQDVQTDYGLRSLPTVYVIDKRGNVADRFMGGSDATLKNMETLIKKLLAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R09</accession>
    <name>Q39R09_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Flagellar protein FliL</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fliL</name>
        <name evidence="10" type="ordered locus">Gmet_3101</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Controls the rotational direction of flagella during chemotaxis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the FliL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514555.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3101"/>
    <dbReference type="EnsemblBacteria" id="ABB33315">
        <property type="protein sequence ID" value="ABB33315"/>
        <property type="gene ID" value="Gmet_3101"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3101"/>
    <dbReference type="eggNOG" id="COG1580">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099018_2_2_7"/>
    <dbReference type="OMA" id="KVEFEMA"/>
    <dbReference type="OrthoDB" id="1833514at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005503">
        <property type="entry name" value="FliL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35091">
        <property type="entry name" value="PTHR35091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03748">
        <property type="entry name" value="FliL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="174" mass="18563" checksum="E5588A9F1BF057A4" modified="2005-11-22" version="1">MAAEENASAEGAPKNKKMLFIIIGAAAVVIIALAVVFMGGKKEKKGEGAEAKVEQKAEGGGAASSGGKEGAAGAAANIFPMEPFIVNIYDGQELRYLRVKVEFETASADAKKEIELRQAPLRDAILVLLTTKTLQDVQDLQGKNQLRDEIMVAVNKILPPGKVSKVYFTDFVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R13</accession>
    <name>Q39R13_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Flagellar biosynthetic protein FliP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">fliP</name>
        <name evidence="14" type="ordered locus">Gmet_3097</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a role in the flagellum-specific transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FliP/MopC/SpaP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514551.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3097"/>
    <dbReference type="EnsemblBacteria" id="ABB33311">
        <property type="protein sequence ID" value="ABB33311"/>
        <property type="gene ID" value="Gmet_3097"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3097"/>
    <dbReference type="eggNOG" id="COG1338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042028_0_1_7"/>
    <dbReference type="OMA" id="MPPNQIL"/>
    <dbReference type="OrthoDB" id="1049349at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005837">
        <property type="entry name" value="FliP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005838">
        <property type="entry name" value="T3SS_IM_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587">
        <property type="entry name" value="PTHR30587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30587:SF0">
        <property type="entry name" value="PTHR30587:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00813">
        <property type="entry name" value="FliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00951">
        <property type="entry name" value="FLGBIOSNFLIP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01302">
        <property type="entry name" value="TYPE3IMPPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01103">
        <property type="entry name" value="fliP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01060">
        <property type="entry name" value="FLIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01061">
        <property type="entry name" value="FLIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7 12" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11 12" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="5 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="14" id="KW-0966">Cell projection</keyword>
    <keyword evidence="14" id="KW-0969">Cilium</keyword>
    <keyword evidence="14" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223277" description="Flagellar biosynthetic protein FliP" evidence="13">
        <location>
            <begin position="25"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB33311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="250" mass="27555" checksum="652C5EBEEBE2332D" modified="2005-11-22" version="1">MTKRILIILTTIAVVAGFAAAALAEPVIPTLSIGVGKASKPGDVSTVLQIFFLMTVLSLAPGLMMMTTSFTRIVIVLSFLRNAIGTQQSPPNQIIVALSLFLTFFVMSPVWQQVNTQAIQPYRAAQITQEEAFRRAQVPVRKFMFSQTREKDLALFINLSKLQRPRNADDIPTLTLIPAFMISELRTAFQIGFLIFIPFLVIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWGLVIGSLVKSFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R31</accession>
    <name>Q39R31_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513638.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3079"/>
    <dbReference type="EnsemblBacteria" id="ABB33293">
        <property type="protein sequence ID" value="ABB33293"/>
        <property type="gene ID" value="Gmet_3079"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3079"/>
    <dbReference type="eggNOG" id="ENOG5033IQV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_205848_0_0_7"/>
    <dbReference type="OMA" id="MRELHEF"/>
    <dbReference type="OrthoDB" id="2001383at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="66" mass="7312" checksum="BAF1876849EEAB79" modified="2005-11-22" version="1">MGYKVKTFGMEIRPLKTMKELSSLDAMVNDFVTNNGVKRIISVSDSPTTDDKGETIGLVRVVAYED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RI1</accession>
    <name>Q39RI1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2925</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366125.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2925"/>
    <dbReference type="EnsemblBacteria" id="ABB33143">
        <property type="protein sequence ID" value="ABB33143"/>
        <property type="gene ID" value="Gmet_2925"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2925"/>
    <dbReference type="HOGENOM" id="CLU_189842_0_0_7"/>
    <dbReference type="OMA" id="LFMSAPK"/>
    <dbReference type="OrthoDB" id="2087410at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223448" evidence="2">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="79" mass="8036" checksum="91629A5FBA76C2BF" modified="2005-11-22" version="1">MKTSARALLALLAASGTALAASGAESEANGFLVTLFLAFGALVIAFQLAPGLILFGSMMKGLFSRPADETVMGDSGNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SE0</accession>
    <name>Q39SE0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511846.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32834">
        <property type="protein sequence ID" value="ABB32834"/>
        <property type="gene ID" value="Gmet_2615"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2615"/>
    <dbReference type="HOGENOM" id="CLU_2422749_0_0_7"/>
    <dbReference type="OMA" id="GHYRQCP"/>
    <dbReference type="OrthoDB" id="2003828at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="92" mass="10386" checksum="C8E97BAA8D4FF617" modified="2005-11-22" version="1">MAEFVKPAYLAFLLVIVVPGVAGGILAANRARNFVGWSILCAVFPIFLLVIYFHKPLREVEGKFWKCRSCGEYLKWQEASCKYCNAPRATVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SE2</accession>
    <name>Q39SE2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Desulfoferrodoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the desulfoferrodoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511848.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2613"/>
    <dbReference type="EnsemblBacteria" id="ABB32832">
        <property type="protein sequence ID" value="ABB32832"/>
        <property type="gene ID" value="Gmet_2613"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2613"/>
    <dbReference type="eggNOG" id="COG2033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118960_2_0_7"/>
    <dbReference type="OMA" id="FEKKHTP"/>
    <dbReference type="OrthoDB" id="1496450at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002742">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036073">
        <property type="entry name" value="Desulfoferrodoxin_Fe-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01880">
        <property type="entry name" value="Desulfoferrodox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49367">
        <property type="entry name" value="SSF49367"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Desulfoferrodox" evidence="8">
        <location>
            <begin position="53"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="161" mass="17350" checksum="4C1584C8946E3642" modified="2005-11-22" version="1">MNRRTFLKTAALGAVAAGITREAAAAAEKYFPVKADQSLFATINRAKDPAKKTPLEQKHAPVIKAPHAVKAGEPFTVEVTVGEQVHPMGPTHWIEYIELNVGNEPAGRIAMQPRGFLHPKVTFTVVIPKEAAPAGKITLVAHQRCNLHGYWEGSLDVAVTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SE6</accession>
    <name>Q39SE6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511852.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2609"/>
    <dbReference type="DNASU" id="3739994"/>
    <dbReference type="EnsemblBacteria" id="ABB32828">
        <property type="protein sequence ID" value="ABB32828"/>
        <property type="gene ID" value="Gmet_2609"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2609"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100182_1_0_7"/>
    <dbReference type="OMA" id="PACGPGC"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="235" mass="25461" checksum="A92850E279927A9A" modified="2005-11-22" version="1">MSEAGSTVPFDFSSYGGEIDDLATRGLADAAGAEGIRTAMARVTGRAEEVQASRLSANEQNLIACGPGCADCCRVNVTVLLPEAIAIAAYLEEIGKGDETNAITMRVADTAARVRWMEDDERIRAGVACPFLDGRGWCAIYPVRPLTCRALSSTDPEQCRRALAAHCSDEEETIVVNIFQKFLMEGTFQSLARAMERAGLDTTGRELCRSVTRCLLDPRLADDFLAGKRIKFPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SG6</accession>
    <name>Q39SG6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2589</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514792.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32808">
        <property type="protein sequence ID" value="ABB32808"/>
        <property type="gene ID" value="Gmet_2589"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2589"/>
    <dbReference type="eggNOG" id="ENOG5032RI1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123180_0_0_7"/>
    <dbReference type="OMA" id="AGFIPWS"/>
    <dbReference type="OrthoDB" id="1792218at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="182" mass="20395" checksum="BD220C23B7DE0A20" modified="2005-11-22" version="1">MNLDDQRVIELSKNKIFLLFLGAWVFVTIGIWLLQMDSAEIESSRRFNSPLFVHAIGVMGILFFGFVGVSWANKLFRKESGLILSPAGIVDNSCGWSAGFIPWSEIVGLDIIQVQYQKIIIIKVTNPNKYIEDRGIVKRVFNSANLKMYGSPITLTSSSLKISFNDLVDECRAYFAKYGGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SH1</accession>
    <name>Q39SH1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEP motif-containing protein, putative exosortase substrate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513450.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32803">
        <property type="protein sequence ID" value="ABB32803"/>
        <property type="gene ID" value="Gmet_2584"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2584"/>
    <dbReference type="HOGENOM" id="CLU_968950_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-CTERM" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="305" mass="31936" checksum="AF5C40832149E3CC" modified="2005-11-22" version="1">MKEHMMQAVTGLFCGLALLAQASVSWGVTLMTENSIDTISFSLPTNAPNAPLSITYGDFESNVSGRIYDNTGALVASGAASNTGSFNGAIDGSIGSSVPVYSTSNRFARVNSATELTPLIGNPDPLADPLNSIFTVIGSTMAGSLGGHSVRAMDSAQYLQFLNVNGTGTGALTASANYIYTFTLGVSPFGEPPFTTNGMTQVHFEMGTFTGSILNYVLNPLVTFDSPLFSMSLLDMADPLNGMDILNLFTSDPLTVNGGSSYYFLARANTDTAVNSVPEPGTIMLVGSGLLGVFLFRKRITGISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SJ2</accession>
    <name>Q39SJ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nitrogen fixation master sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gnfM</name>
        <name evidence="9" type="ordered locus">Gmet_2563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513471.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2563"/>
    <dbReference type="EnsemblBacteria" id="ABB32782">
        <property type="protein sequence ID" value="ABB32782"/>
        <property type="gene ID" value="Gmet_2563"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2563"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="DDQRNMR"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="145"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="480" mass="53888" checksum="BAB5AAF5B74845A9" modified="2005-11-22" version="1">MLLHRILVADDEESMRWVLSKALRKKGFSVDLARDGEEALRLIQSGDYDLAILDIKMPGISGLDLLDRVKELKSDLLMVIMTAEASMKNAVEAMKRGAYDYITKPFDLDVIDAIIEKVNRAREITSQMSILREELKDRYLLEKNIVGNSPAMREVYKTIGKVAPSDVTVLVQGESGTGKELIARAIHFNSKRIGKPFIALNCAAIPKELLESELFGFEKGAFTGAAERKLGKFEQANGGTIFLDEIGDMPLDLQAKILRVLQEKEVTRTGGSQNIAVDVRIVAATNQNLEELARNKQFREDLYYRLNVVPIQLVPLRERKEDIPALVEYFLHKTCAELEVPGRTCSPETMALLTAYSWPGNVRELENTIKRAVILSSDPLLTPADFPGLRIQRTGEAVATDELSLEALVDMKLRASLTNLDKMETGDIYNLVLKQIERPLIRFVLEKTRGNQVKGAEILGINRNTLRKKIQELGIEIRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SJ4</accession>
    <name>Q39SJ4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine synthase</fullName>
            <ecNumber evidence="10">1.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nifR3</name>
        <name evidence="13" type="ordered locus">Gmet_2561</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 10">Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a 5,6-dihydrouridine in tRNA + NAD(+) = a uridine in tRNA + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:54452"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 5,6-dihydrouridine in tRNA + NADP(+) = a uridine in tRNA + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23624"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:13887"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the dus family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513473.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2561"/>
    <dbReference type="EnsemblBacteria" id="ABB32780">
        <property type="protein sequence ID" value="ABB32780"/>
        <property type="gene ID" value="Gmet_2561"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2561"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_0_3_7"/>
    <dbReference type="OMA" id="RPWLFAD"/>
    <dbReference type="OrthoDB" id="1710586at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001269">
        <property type="entry name" value="DUS_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024036">
        <property type="entry name" value="tRNA-dHydroUridine_Synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004652">
        <property type="entry name" value="tRNA_dU_NifR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006621">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00737">
        <property type="entry name" value="nifR3_yhdG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10" id="KW-0288">FMN</keyword>
    <keyword evidence="9 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Dus" evidence="12">
        <location>
            <begin position="17"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00002790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR006621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="324" mass="35290" checksum="4FE5A69A37A32C18" modified="2005-11-22" version="1">MLNPLAIGPLTLANNLILAPMAGITNLPFRLLAREEGASLCFTEMVSVNGLVREGRKTFELLRSVPEDRPLGIQLFGDDPQLLAEGARMVEGHGDLIDINMGCPVKKVVGTGAGSALLREPAKVRAIIRETRRATRLPLTVKIRSGWACGEANFLDIAQIAEEEGCDAITLHPRSRSQMFEGHADWQQIAEMKQSVKIPVIGSGDLFTAADVTAMLAETGCDGVMVARGALGNPWIFRQALALLDGREPDAPSTGERLRAALRHLELFTELAGERVALREMRKHFSWYSHGLSGAAQFRKAVNIIEGKEALLEALHRFFAPEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SL0</accession>
    <name>Q39SL0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2545</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513489.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2545"/>
    <dbReference type="EnsemblBacteria" id="ABB32764">
        <property type="protein sequence ID" value="ABB32764"/>
        <property type="gene ID" value="Gmet_2545"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2545"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_7"/>
    <dbReference type="OMA" id="FKEYHRV"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="2"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="326"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="537"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="358"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="641" mass="71987" checksum="DF3278A8B196D206" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SN9</accession>
    <name>Q39SN9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2513</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514773.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32735">
        <property type="protein sequence ID" value="ABB32735"/>
        <property type="gene ID" value="Gmet_2513"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2513"/>
    <dbReference type="eggNOG" id="ENOG502ZUHZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2716708_0_0_7"/>
    <dbReference type="OMA" id="EIGCVTC"/>
    <dbReference type="OrthoDB" id="1961381at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="73" mass="8094" checksum="027E7C6BFCE38AAD" modified="2005-11-22" version="1">MELKNDLGTTAIQDVIAKYPAIGEILQRYDIGCVTCKVGICLLKDVVSIHGLSKEDESRIEQEINDFLTRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SR7</accession>
    <name>Q39SR7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Tryptophan synthase beta chain</fullName>
            <ecNumber evidence="11">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">trpB</name>
        <name evidence="13" type="synonym">trpB1</name>
        <name evidence="13" type="ordered locus">Gmet_2482</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + H2O + L-tryptophan</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 11">Tetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the TrpB family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="11"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512417.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2482"/>
    <dbReference type="EnsemblBacteria" id="ABB32707">
        <property type="protein sequence ID" value="ABB32707"/>
        <property type="gene ID" value="Gmet_2482"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2482"/>
    <dbReference type="eggNOG" id="COG0133">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016734_3_1_7"/>
    <dbReference type="OMA" id="HGMKSYF"/>
    <dbReference type="OrthoDB" id="912282at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="54"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="11">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="396" mass="43317" checksum="84F424BBC0BF4539" modified="2005-11-22" version="1">MKLPDKQGHFGQFGGRYVPETLMPALLELEKAYNHYKNDREFKEEFDYYLRQYVGRPNPLYFAEKLTQKLGGAKIYLKREDLNHTGAHKVNNTIGQGLLAKRMGKKRVIAETGAGQHGVATATIAALFGMECEVFMGEEDIRRQALNVFRMKLLGAKVTPVTAGTATLKDAMNEAMRNWVTYIHNTFYVIGTVAGPHPYPVMVRDFQSVIGREAKAQHKKIEGRLPDVLVACVGGGSNALGLFYPFLNDREVRMVGVEAAGHGIASGAHAAPLCAGTVGVLHGNKTYLLQDEFGQIANAHSVSAGLDYPGVGPEHAWLKDSRRAEYVSVTDDEALEAFTLLTREEGIMPALESSHAIAHVVKLAPTLPREQTIVACLSGRGDKDIHTVADAMGVQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ST7</accession>
    <name>Q39ST7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512438.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2462"/>
    <dbReference type="EnsemblBacteria" id="ABB32687">
        <property type="protein sequence ID" value="ABB32687"/>
        <property type="gene ID" value="Gmet_2462"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2462"/>
    <dbReference type="HOGENOM" id="CLU_189842_0_0_7"/>
    <dbReference type="OMA" id="ILVWAFM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223356" evidence="2">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="72" mass="7074" checksum="B48726492106CCE6" modified="2005-11-22" version="1">MKAIANALIVTIATASSALAASGAAADEGGFLAPLFLALGVAVVAFQTIPAIVLLGSMVKGLFSAKEEEGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SV9</accession>
    <name>Q39SV9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nickel ABC transporter, membrane protein NikQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nikQ</name>
        <name evidence="7" type="ordered locus">Gmet_2440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CbiQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512460.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2440"/>
    <dbReference type="EnsemblBacteria" id="ABB32665">
        <property type="protein sequence ID" value="ABB32665"/>
        <property type="gene ID" value="Gmet_2440"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2440"/>
    <dbReference type="eggNOG" id="COG0619">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056469_1_2_7"/>
    <dbReference type="OMA" id="IASFMIR"/>
    <dbReference type="OrthoDB" id="1479665at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003339">
        <property type="entry name" value="ABC/ECF_trnsptr_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012809">
        <property type="entry name" value="ECF_CbiQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02361">
        <property type="entry name" value="CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02454">
        <property type="entry name" value="ECF_T_CbiQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="270" mass="29764" checksum="D94DD7B18180E49B" modified="2005-11-22" version="1">MARIETALRDLNRIDLLAGGDSSIHRLDPRAKVLVTLVYIITVVSFSRYEISGLIPFAIFPLAMVAVSGLPPEIVTRKLLLVLPFAALVGLFNPLFDREPLLALGSLAVSGGWVSFLSIILRAALTVGAALVLVAVTGFTGVCLALQRFGVPRAFVVQLLFLYRYIFVLGDEGIRMSRARELRSFAGRGMGLKAYGSLVGSLLLRTWDRAERIHMAMLSRGFRGEFHVRRECSFGRRELAFTAGWCLLFMLLRFVNVPHLIGVLVTGVFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SZ6</accession>
    <name>Q39SZ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512497.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2403"/>
    <dbReference type="EnsemblBacteria" id="ABB32628">
        <property type="protein sequence ID" value="ABB32628"/>
        <property type="gene ID" value="Gmet_2403"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2403"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003728_2_0_7"/>
    <dbReference type="OMA" id="FADFNHA"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="107"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="141"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="267" mass="29558" checksum="12809E42C91586E6" modified="2005-11-22" version="1">MADTFDELLAKGISLAEAGDYTGAAAQFRECVEREPDNAEGYFYLGEALSEEGKLQDALKEYEKGLKLAPDDLDALTAVGDIKFELGQYKEALAAYQRVVALDPDNSDAHVNIGLVYNSLERTQKAIKAFEKALEIDPANVFAYNGLGDAWYGLDEHEKAIAAFQKGIELDPDDAAAHFNLGELYYDLGEHDEAEHECLEAVRLDPAFSMSYLTLGSLYMDNERVKDAIRYLELYLRHEKSPQAKETVAEVQAVLEGLRAEVDSTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T16</accession>
    <name>Q39T16_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ketose-1,6-bisphosphate aldolase, class II, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2383</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514758.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2383"/>
    <dbReference type="EnsemblBacteria" id="ABB32608">
        <property type="protein sequence ID" value="ABB32608"/>
        <property type="gene ID" value="Gmet_2383"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2383"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653212_0_0_7"/>
    <dbReference type="OMA" id="VGRPPNV"/>
    <dbReference type="OrthoDB" id="579700at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="427" mass="46249" checksum="60F8C9FAD13F176E" modified="2005-11-22" version="1">MAPYSAAFEKALQVGRPPNIQKLFPNSKALIVSGKVVDRAMLVKGKAIAMAANGRNYFVIRGALMAAQRANCPIIIEIAKSEGGQKAYCAVNYWNMARIVDALCNELGITVPVAIHADHYGIKNDKDLAAAKVEIPTMFEAGITSIAIDASHLPDDQNLLANLDINPFIPAWAGLETEVGEIKGNQGLSTVDEAKFLIQGLNAHGIHPDWIALNNGTTHGLEASAAGIQVELTAGIHKALEPYKVNGAQHGTSGNSSERLREIANQTATTKANVATALQMISWGLEVNDYGNAQLDADGNFIKVKGEGMTEELWAEIVAYADSKGWKKGDYKNLNLPFENKLLAQPKDIRDRMAKRVEDFAYKMMTEVFNGKDTAPLAIEAILKAGTYDVGSKGSLIEDKSRWTKEQIVERAKTIVSDKGPEGNFED</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T95</accession>
    <name>CHEB2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-glutamate methylesterase/protein-glutamine glutaminase 2</fullName>
            <ecNumber evidence="1">3.1.1.61</ecNumber>
            <ecNumber evidence="1">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cheB2</name>
        <name type="ordered locus">Gmet_2304</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="1"/>
    <dbReference type="EC" id="3.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514494.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T95"/>
    <dbReference type="SMR" id="Q39T95"/>
    <dbReference type="STRING" id="269799.Gmet_2304"/>
    <dbReference type="EnsemblBacteria" id="ABB32529">
        <property type="protein sequence ID" value="ABB32529"/>
        <property type="gene ID" value="Gmet_2304"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2304"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_7"/>
    <dbReference type="OMA" id="ISQHMPA"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264277" description="Protein-glutamate methylesterase/protein-glutamine glutaminase 2">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="1">
        <location>
            <begin position="169"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <sequence length="360" mass="38865" checksum="E727D511511D4470" modified="2005-11-22" version="1">MRKIRVVVIDDSAFNRRAIIKMLESMPEVVVAGYANDGEEGIRKVIDLKPDLVTLDLEMPKMDGFTLLRIIMGYCPTPVIVISAKSDDEKVFKALELGAVDFVAKPSQGISEELLTITDDIQQKVRGVFSLNMKEIIRREKVEVLAPPPVAPKKAEAEPRRVVPCRLDVVAIGSSTGGPPAIQRILSSFREALPLAIVISQHMPAGFTRTFAERLNRLSVFEVKEAADGDTVWPGRVLIAPGGHNMVFEKSSGSVVVRVRKPSPEDRYIPSVDAMLASCAEVFGPRTLGVVLTGMGNDGSRGVRAIKGAGGQALAEAESSAVVFGMPREAIATGVVDKVVPLDLIAREIRMRCGVATDLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TA7</accession>
    <name>GUAA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="1">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">guaA</name>
        <name type="ordered locus">Gmet_2292</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of GMP from XMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + XMP = AMP + diphosphate + GMP + 2 H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514506.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39TA7"/>
    <dbReference type="SMR" id="Q39TA7"/>
    <dbReference type="STRING" id="269799.Gmet_2292"/>
    <dbReference type="EnsemblBacteria" id="ABB32517">
        <property type="protein sequence ID" value="ABB32517"/>
        <property type="gene ID" value="Gmet_2292"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2292"/>
    <dbReference type="eggNOG" id="COG0518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014340_0_5_7"/>
    <dbReference type="OMA" id="KRKIIGH"/>
    <dbReference type="OrthoDB" id="504464at2"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003922">
        <property type="term" value="F:GMP synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0332">GMP biosynthesis</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000229431" description="GMP synthase [glutamine-hydrolyzing]">
        <location>
            <begin position="1"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="GMPS ATP-PPase" evidence="1">
        <location>
            <begin position="203"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="230"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00344"/>
        </source>
    </evidence>
    <sequence length="520" mass="57141" checksum="2EEAEC56199408E4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TD0</accession>
    <name>Q39TD0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2268</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366024.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2268"/>
    <dbReference type="EnsemblBacteria" id="ABB32494">
        <property type="protein sequence ID" value="ABB32494"/>
        <property type="gene ID" value="Gmet_2268"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2268"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_7"/>
    <dbReference type="OMA" id="NRNIGRM"/>
    <dbReference type="OrthoDB" id="1058688at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="7"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="275"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="409" mass="42711" checksum="93A45659B57B1676" modified="2005-11-22" version="1">MGNQNDIVIISAARTPFSKFGGLLKQIHSIELGAMIIREVLQRSGLKGSDIDEVYYGMCIQSEAALKYNVVARQAMLHAGLPPETLSLTVDRACCSSLAAVQLGRKSLLLDEAKVCMAVGAENMSNTPVVLNGHRWGTGLGKPEMVDHLNPIMYVGFNSLAGDAGAVALEYDVSREMQDAWAYASQMKYQAAKAAGKFRPGEEVAAIELSQKKGDPVIFAEDEFPKPNTTPEGLAKLPPVYGSATVTAGNAPGLDAGASALIITKRATADALGVKPLGVILSVASVASAPRGIAEVPAFAIQKALDRASVQLENVDLIEINEAFAAMPLVSTKILADGDQTKWEELLAKTNPNGGAIAIGHPVGASGARILMTAMYELRRRGGGVGVVGICGGLAQGDAAVISVDESCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TE3</accession>
    <name>Q39TE3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein-associated cytochrome b and CCG domain pair iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2255</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366011.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2255"/>
    <dbReference type="EnsemblBacteria" id="ABB32481">
        <property type="protein sequence ID" value="ABB32481"/>
        <property type="gene ID" value="Gmet_2255"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2255"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_7"/>
    <dbReference type="OMA" id="CPMMIEH"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="264"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="338"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="655" mass="72467" checksum="B5F79B91A6ED1593" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TK8</accession>
    <name>Q39TK8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2188</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365945.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32416">
        <property type="protein sequence ID" value="ABB32416"/>
        <property type="gene ID" value="Gmet_2188"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2188"/>
    <dbReference type="HOGENOM" id="CLU_2601054_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003844">
        <property type="entry name" value="UPF0060"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02694">
        <property type="entry name" value="UPF0060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="79" mass="8754" checksum="B2B1A8BB23B3D925" modified="2005-11-22" version="1">MFIKTLGLFVLTALAGILGCYLPYLWLRKNVHWSAWPSSCLRRARYEAAAEGKPQMIYVDGICPAADRSLSAATVHLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TT6</accession>
    <name>Q39TT6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54-dependent sensor transcriptional regulator, PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2109</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513095.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2109"/>
    <dbReference type="EnsemblBacteria" id="ABB32338">
        <property type="protein sequence ID" value="ABB32338"/>
        <property type="gene ID" value="Gmet_2109"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2109"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_8_1_7"/>
    <dbReference type="OMA" id="EHNHENI"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="165"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="128"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="473" mass="53732" checksum="B867722F48317F00" modified="2005-11-22" version="1">MADTEQHLEEMLRLANFTIERTGTPIVWVDSTTRFARVNDAACRCFGYSPDEFIRLTAQDIAPGIPTELWPQHWAELKRMQFRTFSDHFRKRSGEKFPVEVEENFIRFEGREYSCSFIKDMTQHFQTQEALRRALDEVQTLKNRLEAENVYLMNEIKLSNNFDEIVTGNPIFMKALQLVEQVAPTDASVLILGETGVGKELIARAIHNLSNRRDRPLIRLNCAALPATLMENELFGHERGAFTGANCRKPGRFDLADGGTLFLDEVGDLPMELQSKLLRVLQEGEFERLGGAETIKVDVRILAATHVDLKALLAEGRFRSDLYYRLNVFPIQCPPLRERREDIPLLVRHFVKASCEKNGKSIELIPRHVMESLEGYPWPGNIRELQNVIERAVIISRGNKLEIDSLPKMVIAADAAPISPLEVTEREHIIRALETTAWRVGGPKGAAEILGLKRTTLQARMRKLGINRQGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TV3</accession>
    <name>Q39TV3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2092"/>
    <dbReference type="EnsemblBacteria" id="ABB32321">
        <property type="protein sequence ID" value="ABB32321"/>
        <property type="gene ID" value="Gmet_2092"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2092"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003028_0_0_7"/>
    <dbReference type="OMA" id="THDIYEE"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1071" mass="125807" checksum="8586550913694599" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TW9</accession>
    <name>Q39TW9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfur carrier protein FdhD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fdhD</name>
        <name evidence="4" type="ordered locus">Gmet_2076</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FdhD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514589.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39TW9"/>
    <dbReference type="STRING" id="269799.Gmet_2076"/>
    <dbReference type="EnsemblBacteria" id="ABB32305">
        <property type="protein sequence ID" value="ABB32305"/>
        <property type="gene ID" value="Gmet_2076"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2076"/>
    <dbReference type="eggNOG" id="COG1526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056887_4_1_7"/>
    <dbReference type="OMA" id="ECTELVE"/>
    <dbReference type="OrthoDB" id="948173at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015626">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="3">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="263" mass="28406" checksum="15B3CA41773763BB" modified="2005-11-22" version="1">MKSIYHYDKGKLAATEKEFVGEFPLLLNVNGREIATLIASPHDLRFLVAGFLRLQGFVEKVEDFQLLSVCNDFGIARVQIKGELPEKLKPVLTSGCGTGITFTIPQATKGRSDSLAARHFSPAAVFAMMEELARKAEGYRSHGGMHSAAVGDGSIVLYAEDLGRHNTLDRIAGEALLRGIDLAGTMLVTSGRVSTEMVAKCVLLGIQLIASRTSPTDMAVRMADEAGITMIGYVRGGRFELYTHPERLRVDSLEEGCACATGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U13</accession>
    <name>Q39U13_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512918.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2032"/>
    <dbReference type="EnsemblBacteria" id="ABB32261">
        <property type="protein sequence ID" value="ABB32261"/>
        <property type="gene ID" value="Gmet_2032"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2032"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007251_0_1_7"/>
    <dbReference type="OMA" id="RMLADSM"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014266">
        <property type="entry name" value="PEP-CTERM_TPR_lipo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="21"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02917">
        <property type="entry name" value="PEP_TPR_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="126"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="194"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="363"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="665"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="699"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="883" mass="97099" checksum="8995FEDFCE6A57A9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U21</accession>
    <name>Q39U21_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">asnB-2</name>
        <name evidence="8" type="ordered locus">Gmet_2024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asparagine synthetase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512926.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2024"/>
    <dbReference type="EnsemblBacteria" id="ABB32253">
        <property type="protein sequence ID" value="ABB32253"/>
        <property type="gene ID" value="Gmet_2024"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2024"/>
    <dbReference type="eggNOG" id="COG0367">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_457729_0_0_7"/>
    <dbReference type="OMA" id="KGHCDSE"/>
    <dbReference type="OrthoDB" id="1159670at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_Synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="7">
        <location>
            <begin position="66"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Asparagine synthetase" evidence="6">
        <location>
            <begin position="240"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="5">
        <location>
            <position position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="656" mass="73402" checksum="8D732FFE5580A859" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U23</accession>
    <name>Q39U23_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2022</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512928.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2022"/>
    <dbReference type="EnsemblBacteria" id="ABB32251">
        <property type="protein sequence ID" value="ABB32251"/>
        <property type="gene ID" value="Gmet_2022"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2022"/>
    <dbReference type="eggNOG" id="ENOG5033Q6T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_849312_0_0_7"/>
    <dbReference type="OMA" id="VGQENYI"/>
    <dbReference type="OrthoDB" id="1832083at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="327" mass="37943" checksum="E4A5CEE0889DFFF8" modified="2005-11-22" version="1">MKRTLDYTFTTNYADHRQNIHSFWERINGHRNERFFDSFYAGNPAGESYLGLCYDGERLVGQENYIPQDVACAGTLYRSAMGVNTLVDPDYRLFHGVFGKLCRLTTDELEQKVDLLFAYANEESKKYYLKYFNWKITAKVGVYKKITNASGLNAESVLSFVKPGRRHADLSLNLVSRFSPEQLDPVLERYRRASKHAYFHKTAAFLNWKFLGNLHYQTTGYQIMAGDRVCGYCVTYDTGSERKILDIIVEGDDPELFRKAISHLARLASEQGIQRLVIYATPDAWYEPLLRKMVFLKRWDIDFLTHAFTDNLPDKGWVVHCGDFDMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U26</accession>
    <name>Q39U26_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Decarboxylase, BtrK-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512931.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2019"/>
    <dbReference type="EnsemblBacteria" id="ABB32248">
        <property type="protein sequence ID" value="ABB32248"/>
        <property type="gene ID" value="Gmet_2019"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2019"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_3_7"/>
    <dbReference type="OMA" id="NISHHDF"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017530">
        <property type="entry name" value="DCO2ase_PEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03099">
        <property type="entry name" value="dCO2ase_PEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="3">
        <location>
            <begin position="28"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="4">
        <location>
            <begin position="33"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="419" mass="45806" checksum="CC9CBD94635F0EE2" modified="2005-11-22" version="1">MILTEQNGKTCLRNICFEELAARYGTPFYLYDLDKVKEKCAAVRKAFGDSLELLYAVKANPNRELLAAMRGEVDGLDIASAGELERALETGYDAGCISFAGPGKTRDELRRSLEAGVGCISVESLRELNDLRDLVRAGSHRAYILVRVNPQLLIRDFAVKMGGKASQFGIDEEELPSALDFIKANADAFDFKGIHIYAGTQCLNEEALAQNLANTLAIAARITTDYGMECRVINIGGGLGVSYYEEHPGLDLDKLALLFRAEFDRYREATGTKPRILLELGRFLVAEAGIYVTRVVSEKLSRGEQFYVLDGGMNHHLSASGNLGMTIRKNYLVRNLSRPGAERIICTLVGPLCTPLDLMGKGVTVEVPEVGDLVGFLNSGSYGYSASPLLFLGHGEPCELLVEGKDVRPCRLMGEMGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U58</accession>
    <name>Q39U58_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional ligase/repressor BirA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Biotin--[acetyl-CoA-carboxylase] ligase</fullName>
            <ecNumber evidence="3">6.3.4.15</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Biotin--protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Biotin-[acetyl-CoA carboxylase] synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">birA</name>
        <name evidence="5" type="ordered locus">Gmet_1987</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 3">
            <text>ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:11756"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.15" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512964.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1987"/>
    <dbReference type="EnsemblBacteria" id="ABB32216">
        <property type="protein sequence ID" value="ABB32216"/>
        <property type="gene ID" value="Gmet_1987"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1987"/>
    <dbReference type="eggNOG" id="COG0340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1654">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051096_0_0_7"/>
    <dbReference type="OMA" id="DESVNGW"/>
    <dbReference type="OrthoDB" id="1842956at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin-[acetyl-CoA-carboxylase] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00978">
        <property type="entry name" value="Bifunct_BirA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030855">
        <property type="entry name" value="Bifunct_BirA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003142">
        <property type="entry name" value="BPL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013196">
        <property type="entry name" value="HTH_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008988">
        <property type="entry name" value="Transcriptional_repressor_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02237">
        <property type="entry name" value="BPL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08279">
        <property type="entry name" value="HTH_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50037">
        <property type="entry name" value="SSF50037"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 3" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="4">
        <location>
            <begin position="82"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="3">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="3">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Biotin binding" evidence="3">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="338" mass="36575" checksum="5C1533590A6C62E5" modified="2005-11-22" version="1">MSGELPRPDAIGSKEIDRKILEIFRSRDGGVVSGEELSRSLDVSRTAVWKHIKTLNGLGYRIEAVPSRGYRLVSTPDILTPAELSVGLNVARIGTSLVFVGETDSTNTLAYRLAEDGAVEGTVVIADAQNRGRGRLGRQWESPAGVNLYCSIILRPPIMPLHAPQLTFLSAVAVAEAIERSAGLAPVIKWPNDVLVNGFKVAGMLNEMSAETERIDFLVLGIGVNINMQRDQFPTDLRHPASSLAIEAGHEVSRLSFARALLESLDVHYSQYRSEGYAPLRQAWLGRSAVMGRRVRVSGNQGDMTGTVEGIDEIGALLLRTAHGTLERVLAGDVTIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U65</accession>
    <name>Q39U65_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methanethiol S-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.334</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_1980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methylation of methanethiol (MeSH) to yield dimethylsulphide (DMS).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>methanethiol + S-adenosyl-L-methionine = dimethyl sulfide + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:50428"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16007"/>
            <dbReference type="ChEBI" id="CHEBI:17437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.334"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the nurim family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.334" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512971.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1980"/>
    <dbReference type="EnsemblBacteria" id="ABB32209">
        <property type="protein sequence ID" value="ABB32209"/>
        <property type="gene ID" value="Gmet_1980"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1980"/>
    <dbReference type="eggNOG" id="COG2020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084189_1_0_7"/>
    <dbReference type="OMA" id="YVRHPYY"/>
    <dbReference type="OrthoDB" id="1734625at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009915">
        <property type="entry name" value="NnrU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033580">
        <property type="entry name" value="Nurim-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31040">
        <property type="entry name" value="PTHR31040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07298">
        <property type="entry name" value="NnrU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="NnrU" evidence="10">
        <location>
            <begin position="4"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="193" mass="22025" checksum="55BD16B79F017E36" modified="2005-11-22" version="1">MADFIARLFVFALTHSILALPALQRRMGDIFPRLGRFYRFAYNLVALVTFTWALSAWHFSPVVYIVPGTGSLIFYLIQLVFIVLLARCAAQTGIDELLGLRQMRGTPGSKQLVTTGCYARVRHPLYSLSVVFLALNPVMTLKWLLLTVFSAVYFVIGARIEERRLIAEYGETYRNYQKNVPMFIPAKKEVPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U87</accession>
    <name>Q39U87_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Chromosome segregation and condensation protein ScpB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">scpB</name>
        <name evidence="5" type="ordered locus">Gmet_1958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511886.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1958"/>
    <dbReference type="EnsemblBacteria" id="ABB32187">
        <property type="protein sequence ID" value="ABB32187"/>
        <property type="gene ID" value="Gmet_1958"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1958"/>
    <dbReference type="eggNOG" id="COG1386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045647_5_3_7"/>
    <dbReference type="OMA" id="DGWRFYT"/>
    <dbReference type="OrthoDB" id="1771906at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051304">
        <property type="term" value="P:chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005234">
        <property type="entry name" value="ScpB_csome_segregation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34298">
        <property type="entry name" value="PTHR34298"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04079">
        <property type="entry name" value="SMC_ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019345">
        <property type="entry name" value="ScpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00281">
        <property type="entry name" value="TIGR00281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="195" mass="22200" checksum="DB94605F33CBE079" modified="2005-11-22" version="1">MPNLKSIVESLLFVADAPMTFDRLCSFLDEFDRGDIREALGALQEEYGQEGRGVVLVEVASGYQFRTPVENADYLRRLTKTRPVKFSQSALETLAIIAYRQPVTRAEIEYLRGVDCGGVLKTILEKKLIKILGKKDIPGKPLIYGTTREFLELFSLKDLRSLPTLKEIRDLSETASYEQQEELPLEQPEDDRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UD6</accession>
    <name>Q39UD6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine-5'-phosphate oxidase-related FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511935.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="DNASU" id="3740313"/>
    <dbReference type="EnsemblBacteria" id="ABB32138">
        <property type="protein sequence ID" value="ABB32138"/>
        <property type="gene ID" value="Gmet_1909"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1909"/>
    <dbReference type="eggNOG" id="COG3576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123805_0_0_7"/>
    <dbReference type="OMA" id="QVQWRLE"/>
    <dbReference type="OrthoDB" id="1927451at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="3"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="13951" checksum="5FA4412F0044EFA5" modified="2005-11-22" version="1">MIPETVQKFVEERGIAFVASATLQGVPHLAAGENLKVEGSDRIVFESWCCPETLRNVKGNPKVSVSVTTPDGRNGYQFLGIVEKVTDTAILDGFVPGLEVPGMPQVASRLEVRVGAILTFSVGVHTDKPM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UG1</accession>
    <name>ACPS_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holo-[acyl-carrier-protein] synthase</fullName>
            <shortName evidence="1">Holo-ACP synthase</shortName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4'-phosphopantetheinyl transferase AcpS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpS</name>
        <name type="ordered locus">Gmet_1884</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="EC" id="2.7.8.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the P-Pant transferase superfamily. AcpS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511960.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UG1"/>
    <dbReference type="SMR" id="Q39UG1"/>
    <dbReference type="STRING" id="269799.Gmet_1884"/>
    <dbReference type="PRIDE" id="Q39UG1"/>
    <dbReference type="EnsemblBacteria" id="ABB32113">
        <property type="protein sequence ID" value="ABB32113"/>
        <property type="gene ID" value="Gmet_1884"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1884"/>
    <dbReference type="eggNOG" id="COG0736">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089696_3_1_7"/>
    <dbReference type="OMA" id="DERHYAV"/>
    <dbReference type="OrthoDB" id="1893660at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="SSF56214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00516">
        <property type="entry name" value="acpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000228288" description="Holo-[acyl-carrier-protein] synthase">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00101"/>
        </source>
    </evidence>
    <sequence length="126" mass="14352" checksum="7D790C5E3CA5FED7" modified="2005-11-22" version="1">MIFGTGIDIVDITRFERFLEERNTRLFERLFTIHEQEYCAGKAHSAQHYALRFAAKEAFLKACGLGLREGLTWHDVEVVNDSLGKPDLRLYGKAQQLFADMNLSKTFVSLSHDGNFAVAMVVLERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UH4</accession>
    <name>Q39UH4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Lon protease</fullName>
            <ecNumber evidence="6 7">3.4.21.53</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent protease La</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">lon-2</name>
        <name evidence="6" type="synonym">lon</name>
        <name evidence="15" type="ordered locus">Gmet_1871</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7 10">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6 7">Homohexamer. Organized in a ring with a central cavity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="induction">
        <text evidence="6">By heat shock.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7 10 11">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="6 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365882.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1871"/>
    <dbReference type="MEROPS" id="S16.001"/>
    <dbReference type="EnsemblBacteria" id="ABB32100">
        <property type="protein sequence ID" value="ABB32100"/>
        <property type="gene ID" value="Gmet_1871"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1871"/>
    <dbReference type="eggNOG" id="COG0466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004109_4_3_7"/>
    <dbReference type="OMA" id="GAWQVVD"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01973">
        <property type="entry name" value="lon_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027543">
        <property type="entry name" value="Lon_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004815">
        <property type="entry name" value="Lon_bac/euk-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008268">
        <property type="entry name" value="Peptidase_S16_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001174">
        <property type="entry name" value="Lon_proteas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00763">
        <property type="entry name" value="lon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01046">
        <property type="entry name" value="LON_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword evidence="6 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Lon N-terminal" evidence="14">
        <location>
            <begin position="18"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Lon proteolytic" evidence="13">
        <location>
            <begin position="599"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8 10">
        <location>
            <position position="686"/>
        </location>
    </feature>
    <feature type="active site" evidence="6 8 10">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6 9">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001174-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB32100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="805" mass="89044" checksum="C6E98F11F962773F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UL1</accession>
    <name>Q39UL1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1834</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512012.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1834"/>
    <dbReference type="EnsemblBacteria" id="ABB32063">
        <property type="protein sequence ID" value="ABB32063"/>
        <property type="gene ID" value="Gmet_1834"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1834"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_818262_0_0_7"/>
    <dbReference type="OMA" id="LIMFRAG"/>
    <dbReference type="OrthoDB" id="1454315at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="Pentatricopeptide_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="339" mass="37245" checksum="9C2FCED014015420" modified="2005-11-22" version="1">MFFSKLFRKDAASCLEKGEKLLAAGRFAEARLSLEDALERLDAHSPEGATTAAVIREKMVVAGNRLAEMNLQEAEHCLKSGEFAKAEEHLNLTLDLADDVTIRDKAVKSFALLEKQIPHVHHHEKKGGCGGCGGSTSQHSENIELEDDGLNDMDRFELLVRPLPGDLPERYADLGEEFAGGYLAAHGGDQMTAEKVFERLLASGESDILLYELAILSHQGGDGRRCETLLRRALALNDTNPLCNLSLVQLLTENGRFTEAVPLLERMVERDILPDQAGMFLGEIYRVQGESDRAIAQFSQLLSTPLKREAAERLVGLLETTGRSQEAALVAKQYLKGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UP8</accession>
    <name>Q39UP8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32026.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32026">
        <property type="protein sequence ID" value="ABB32026"/>
        <property type="gene ID" value="Gmet_1795"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1795"/>
    <dbReference type="eggNOG" id="ENOG5033T4U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_638986_0_0_7"/>
    <dbReference type="OMA" id="NTCFDEL"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32026.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="429" mass="47551" checksum="D615CFA73B5C4AA8" modified="2012-10-31" version="2">MVEEDTVTRMLYNETDSGEFTRKVVTLLGEATALQGTLHMPGVRDDYRSRLEQVVLLARRALGNAGENREVALLQWVLVQALGARGEDARYGAGQLSRGSQRAPTLEDCEDGWQRVEQIVCNAEDAALETARIAQLLNTAKAREIARRAEVAGKAARKIVLERNRAYTFHADPGFSFGEGWYLAAAALFAGLSIQIRPGAAQELQVRRFLFDAGLEGSLRPYRSRPASPKHLTHIIAEAFRTDAPGAQCTLRAGFLGDESPSAALRSWIDGKVGGKLEQKVLLWVRTGDHDAQRNTCFDELRQLSELVLNAGLTPIFFGDKVPLELVPPSAVNLTLCWKEPLFQGPDMRRAQLQLFEELRCRHGLVGQIGVTTAGMDGPALMGLPTLYLTQERNVRLGKWVGAVPGYQEVVREPGYFEIIRTTQHHWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UV5</accession>
    <name>Q39UV5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ammonium transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513367.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1738"/>
    <dbReference type="EnsemblBacteria" id="ABB31969">
        <property type="protein sequence ID" value="ABB31969"/>
        <property type="gene ID" value="Gmet_1738"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1738"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_1_7"/>
    <dbReference type="OMA" id="CAGSDVM"/>
    <dbReference type="OrthoDB" id="562287at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="6">
        <location>
            <begin position="18"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="406" mass="42892" checksum="AD19A6EDC07FC329" modified="2005-11-22" version="1">MDQLSMATGLKNSTDVLFLMLGAVMVFAMHAGFAFLEVGTVRKKNQVNAFVKILTDWSVSTIAYFMVGFPIAYGISFLVPAGDLMGATQGYDLVHYFFLLCFSACIPAIISGGIAERAKFWPQVFAGALFAALTYPIFESLIWGKNASILQGFFKSIGGAEFHDYAGSVVVHSMGGWLALPAVLTLGPRMGRYIRSKSHPIPISNIPFLALGSWILAVGWFGFNVMSAGHLDKISGLVAVNSLLAMVGGVLAALLAGKNDPGFIHNGALAGLIAVCAGSDIIHPLGAFATGAIASVIFVYGFQIEQERLKIDDVLGVWPLHGIIGSWGGIAAGIFGQPLLGGIGGISFISQLLGTVAAILFALANGFLVYTVLSKTVGIRLSDEEEFAGADLSIHKIGAYPEDHVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UZ7</accession>
    <name>Q39UZ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3-oxoacyl-(Acyl carrier protein) synthase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514158.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1696"/>
    <dbReference type="DNASU" id="3741372"/>
    <dbReference type="EnsemblBacteria" id="ABB31927">
        <property type="protein sequence ID" value="ABB31927"/>
        <property type="gene ID" value="Gmet_1696"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1696"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796345_0_0_7"/>
    <dbReference type="OMA" id="SPMLFPN"/>
    <dbReference type="OrthoDB" id="1104717at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_KS" evidence="1">
        <location>
            <begin position="8"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="346" mass="35872" checksum="A80166DE363AE7BF" modified="2005-11-22" version="1">MKPVTHDIVVTGLAAISAAGVGLETLAAAISDGQSRLRPVPEDLAGGGHLWGPADGFRAADFMPPLKARKFDRCSLMAVAAAGMALRDAVLDLKGVDPTRVGIVLGCGFGGIANSVEFLSGYFTGGVDGLSPMLFPNTVANAAASNASIEHGIQGPNVTFVQRFCSAETALTMGCRFLEEGRADVIIAGGVDELNAMMIRGFDAMKQLGSYAGGFGEGCGLLVLERRDHAERRRAPVRGRIAGIRSVGLILPGAEDEGVARLLPENLSQYRISVSGTADLSPRLMERLPGAPQLQLHRLTGRSLAMGGLALAALLLTLREGEQGLHLAASPEGPFVAIEISGGAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UZ8</accession>
    <name>Q39UZ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3-oxoacyl-(Acyl carrier protein) synthase II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fabF-1</name>
        <name evidence="4" type="ordered locus">Gmet_1695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514159.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1695"/>
    <dbReference type="EnsemblBacteria" id="ABB31926">
        <property type="protein sequence ID" value="ABB31926"/>
        <property type="gene ID" value="Gmet_1695"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1695"/>
    <dbReference type="eggNOG" id="COG0304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_69_2_7"/>
    <dbReference type="OMA" id="DSSDAHH"/>
    <dbReference type="OrthoDB" id="606297at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="PTHR11712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="B_KETOACYL_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_KS" evidence="3">
        <location>
            <begin position="6"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="401" mass="41082" checksum="8AFE8C8AE76565F9" modified="2005-11-22" version="1">MSAGVVAITGLGIFCGAGKDIPSFTDALMNGKSGVAPLDLFDVSDFPSKIGVQVKEYDPLDHFDRKAVSRLSRADQFGVIAAGEALRASGIGKHCSPYDMGVVVGGGAAGMFQSEQWLKERIAGRKGRPSLLRGLLPDKASTVIAETFGLAGYQGTITTACSSSATAIGWGADLVSSGRLKAVVCGGTDTLSLLTFAGFNSLRVVDPEPCSPFSLGRQGISLGEGAAFMVLEDADAARQRGATVYGHVRGYAAAGEAYHMTAPEPSGTAAARVMTEAMRIAGIDAGAVGWVNAHGTGTPLNDAVESKAMKLVFGEGVANVPLVSTKALTGHCLGAAGAVEGVATVIALNEGIIPQTLHFRGRDPECDLDYCHDGPRASGATVALSNSFAFGGNITTLVLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V04</accession>
    <name>Q39V04_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acpP-1</name>
        <name evidence="5" type="ordered locus">Gmet_1689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514165.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1689"/>
    <dbReference type="EnsemblBacteria" id="ABB31920">
        <property type="protein sequence ID" value="ABB31920"/>
        <property type="gene ID" value="Gmet_1689"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1689"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_14_1_7"/>
    <dbReference type="OMA" id="RADHEDN"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="3"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="3">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="85" mass="9177" checksum="50288CDA662639FA" modified="2005-11-22" version="1">MADQLIEEVKQLIIDALRIEGMTPAEIDTDAPLFGEGLGLDSIDALQLVVAMEKQYGVVVPDAATGTKVFQSVRTVADFVAENRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V06</accession>
    <name>Q39V06_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1687</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514167.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1687"/>
    <dbReference type="EnsemblBacteria" id="ABB31918">
        <property type="protein sequence ID" value="ABB31918"/>
        <property type="gene ID" value="Gmet_1687"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1687"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044700_0_0_7"/>
    <dbReference type="OMA" id="YADKLWY"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="106"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="460" mass="52478" checksum="8860D1A79278E39A" modified="2005-11-22" version="1">MLQSLKNYSTEKIVSLLLSLATNSSNETLARMTHLMELIPKKDYYRERIRWIRQLIRENHPSIEFPRRILRDLHPNQRDKWITNLAVNHLLIGTNKRKAWADREGYYPPSTVVISPTMKCNLSCYGCYAGDYGKGLELSLEEVDSVLTQMKEMGVYFAVISGGEPFFMPNIFEIFRKHSDMAFLVFTHGGLIDEAMVERLIEVGNVMPAFSLEGYEPETDERRGPGHFRKVMGAMDLLRNAGLSFCGSFTQTSRNTPVITDGSFIDMLLEKGVFALWLFTYVPVGRDPNLELMATPEQRDLLRTRVAEFRATKPMLFIDFWNDGPIISGCIAGGRKYFHINANGDIEPCVFCHFAVDNIRRTSLKDALRSPLFQKIRQQQGEHENLLRPCMLIDHPEVGRELFNSEGVYPTHEGAAEIFTGLAGQVDAYATEYAGIADPAWEREFVDTGRAEKKVKNRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V35</accession>
    <name>Q39V35_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">7-carboxy-7-deazaguanine synthase</fullName>
            <shortName evidence="5">CDG synthase</shortName>
            <ecNumber evidence="5">4.3.99.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuosine biosynthesis protein QueE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">queE</name>
        <name evidence="7" type="ordered locus">Gmet_1658</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>6-carboxy-5,6,7,8-tetrahydropterin + H(+) = 7-carboxy-7-deazaguanine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:27974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:61032"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="EC" id="4.3.99.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </cofactor>
        <text evidence="5">Binds 1 S-adenosyl-L-methionine per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.3.99.3" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365854.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1658"/>
    <dbReference type="EnsemblBacteria" id="ABB31889">
        <property type="protein sequence ID" value="ABB31889"/>
        <property type="gene ID" value="Gmet_1658"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1658"/>
    <dbReference type="eggNOG" id="COG0602">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066739_1_0_7"/>
    <dbReference type="OMA" id="IPQTHKM"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016840">
        <property type="term" value="F:carbon-nitrogen lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00917">
        <property type="entry name" value="QueE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024924">
        <property type="entry name" value="7-CO-7-deazaguanine_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="21"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="5">
        <location>
            <begin position="40"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="250" mass="27739" checksum="051CEB44FBE9A4CB" modified="2005-11-22" version="1">MSKPTAELAEVFSSVQGEGMLIGLRQVFVRFRGCNLTCDYCDTPTEITAEPCLVEQTPGRRDFVPTANPVALDRIVSLIDGWQRGWPGVHHSISITGGEPLLSHTVLSAWLPELRNILPVYLETNGIMHSVLGLLIDHIDIIGMDIKIPSTSGCTGLWDDHRSFLQIAARKNVFVKIIVGDETEEWEIIRASELIAAINSHIPLILQPVTEPGGRVGINPVRALEFQEIACRHLDEVRIIPQTHKFMAQL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VA2</accession>
    <name>RS15_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsO</name>
        <name type="ordered locus">Gmet_1590</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511475.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VA2"/>
    <dbReference type="SMR" id="Q39VA2"/>
    <dbReference type="STRING" id="269799.Gmet_1590"/>
    <dbReference type="EnsemblBacteria" id="ABB31822">
        <property type="protein sequence ID" value="ABB31822"/>
        <property type="gene ID" value="Gmet_1590"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1590"/>
    <dbReference type="eggNOG" id="COG0184">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148518_0_0_7"/>
    <dbReference type="OMA" id="FKTHVKD"/>
    <dbReference type="OrthoDB" id="1990141at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_B">
        <property type="entry name" value="Ribosomal_S15_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_S15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_S15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="S15_NS1_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="PTHR23321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="SSF47060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00952">
        <property type="entry name" value="S15_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000255497" description="30S ribosomal protein S15">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01343"/>
        </source>
    </evidence>
    <sequence length="88" mass="10563" checksum="DDB546244C61DC40" modified="2005-11-22" version="1">MLVTDKKQEIITSFKRHDSDTGSPEVQIAILTERIIYLTEHFKVHKKDHHSRRGLLKIVGQRRRLLDYLKKKDVERYRAIIEKLGIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VD7</accession>
    <name>Q39VD7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_1553</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511514.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1553"/>
    <dbReference type="EnsemblBacteria" id="ABB31787">
        <property type="protein sequence ID" value="ABB31787"/>
        <property type="gene ID" value="Gmet_1553"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1553"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_4_7"/>
    <dbReference type="OMA" id="MNYGGIS"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="21"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="288"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="386" mass="41505" checksum="534E1B3CDA4C2A49" modified="2005-11-22" version="1">MKLHSISLNNLRRRKAKMAFLTIGLMVGIATIVTLVTLTESMSNDIGRKMDEFGANILIMPRSEDLAMSYGGISLGRVSFDQQEIHEGDLARIREIKNNKNILAVSPKVLGAATLKEKNVLLVGVNFAEELKMKQWWRIFGDEPKTENEILLGSTTADTLHLSPGDSVTIGGEALKVAGILEQTGSQDDSLVFAPLKKAQKILGKEDKITLVEVAALCAGCPIGDMVVQIAEKLPEAKVTAIQQVVESRLKTLDQFKRFSYGVAGVVIFIGSLIVFVTMMGSVNERTTEIGVFRAIGFRKSHIMRIILLEASLVSLLAGALGYLSGMGAARLALPFMAESAKAALVWDGLVASGSIGLAVTVGLLASLYPALHASRMDPTEALRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VJ8</accession>
    <name>Q39VJ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511575.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1492"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31726">
        <property type="protein sequence ID" value="ABB31726"/>
        <property type="gene ID" value="Gmet_1492"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1492"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_7"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="13"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="188"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="373" mass="42236" checksum="9E52C207935FC950" modified="2005-11-22" version="1">MRIAYIVTDLGRGGTQGWVEYSALELVKYGHSITIIAENTPHDRKAKFEEHGIVVRAFERPASRSDYCRIIQEARADVIHLHVWERFSELIQLRELCNVPVLLSYHSVPKIGWKQWVARIIKPSVNHWDMYDWFTLKQARQYIDAHIGCCKASAGGIRNKYWPFMGKRVFPLPNAIPFPEANMASVISGPPKFLQVGALNERKNPFLTLKAFHNIQRRISDSTLTFVGGGPLFEELKGYVHQMGVENVFLVGEVQDPSPYYMASNILVQPSRSEGLPYTLIEGAGRGMALIASNVDGNPEICIAKRNGLLLPDISENALQEAMLNLALNHEERSRMGSCGRRLVEENFSMKLFVKRLLKIYETVIERKPCPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VQ9</accession>
    <name>Q39VQ9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UDP-glucuronate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.35</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">uxs</name>
        <name evidence="8" type="ordered locus">Gmet_1431</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511637.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1431"/>
    <dbReference type="EnsemblBacteria" id="ABB31665">
        <property type="protein sequence ID" value="ABB31665"/>
        <property type="gene ID" value="Gmet_1431"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1431"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_4_0_7"/>
    <dbReference type="OMA" id="PKVKYLN"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="PTHR43078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="7">
        <location>
            <begin position="4"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="313" mass="34523" checksum="757C9865317512DB" modified="2005-11-22" version="1">MRVLVTGGAGFIGSHLCERLVSDGHEVLCVDNFFTGSKQNILPLLGNPRFELIRHDITEPILLEVDQIYHLACPASPVHYQYNPVKTIKTSVMGTINMLGLAKRVRARILLASTSEVYGDPQVHPQPETYWGNVNPIGIRSCYDEGKRVAETLMMDYHRQNGVDIRIVRIFNTFGPRMAEHDGRVVSNFIVQALKGEDITVYGDGSQTRSFCYVSDLVEGLVRTMSCEGFTGPVNLGNPGETTILEFARRIIALTGSQSQIVFRPLPSDDPKQRQPDITLARTTLGWEPIVPLETGLTKTVDYFSGLGAGSGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VR8</accession>
    <name>APT_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Adenine phosphoribosyltransferase</fullName>
            <shortName evidence="1">APRT</shortName>
            <ecNumber evidence="1">2.4.2.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">apt</name>
        <name type="ordered locus">Gmet_1422</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + adenine</text>
            <dbReference type="Rhea" id="RHEA:16609"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.4.2.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511645.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VR8"/>
    <dbReference type="SMR" id="Q39VR8"/>
    <dbReference type="STRING" id="269799.Gmet_1422"/>
    <dbReference type="EnsemblBacteria" id="ABB31656">
        <property type="protein sequence ID" value="ABB31656"/>
        <property type="gene ID" value="Gmet_1422"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1422"/>
    <dbReference type="eggNOG" id="COG0503">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063339_3_0_7"/>
    <dbReference type="OMA" id="KPGIVFR"/>
    <dbReference type="OrthoDB" id="1532478at2"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00646"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003999">
        <property type="term" value="F:adenine phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006168">
        <property type="term" value="P:adenine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00004">
        <property type="entry name" value="Aden_phosphoribosyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005764">
        <property type="entry name" value="Ade_phspho_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01090">
        <property type="entry name" value="apt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0660">Purine salvage</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000000288" description="Adenine phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00004"/>
        </source>
    </evidence>
    <sequence length="171" mass="18722" checksum="FE77A607DE3055F2" modified="2005-11-22" version="1">MDELKNIIRDIPDFPKKGIVFKDITTLLADAKSFQRMVDLLAHRYVGEKIDKVVGVEARGFILGAALAYKLGAGVVLVRKPGKLPSETFSKTYQLEYGTDSLEIHTDAIRKGEKVLIADDVLATGGTMSAVVEMVRDLGGEIVECCFLAELDFLGGRKKLPDGKVFSLLTF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VS6</accession>
    <name>RL20_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplT</name>
        <name type="ordered locus">Gmet_1414</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511653.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VS6"/>
    <dbReference type="SMR" id="Q39VS6"/>
    <dbReference type="STRING" id="269799.Gmet_1414"/>
    <dbReference type="EnsemblBacteria" id="ABB31648">
        <property type="protein sequence ID" value="ABB31648"/>
        <property type="gene ID" value="Gmet_1414"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1414"/>
    <dbReference type="eggNOG" id="COG0292">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123265_0_1_7"/>
    <dbReference type="OMA" id="GRRKNVW"/>
    <dbReference type="OrthoDB" id="1932144at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07026">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00382">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005813">
        <property type="entry name" value="Ribosomal_L20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035566">
        <property type="entry name" value="Ribosomal_protein_L20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10986">
        <property type="entry name" value="PTHR10986"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00453">
        <property type="entry name" value="Ribosomal_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00062">
        <property type="entry name" value="RIBOSOMALL20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74731">
        <property type="entry name" value="SSF74731"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01032">
        <property type="entry name" value="rplT_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00937">
        <property type="entry name" value="RIBOSOMAL_L20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000243685" description="50S ribosomal protein L20">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00382"/>
        </source>
    </evidence>
    <sequence length="117" mass="13345" checksum="1A76ABDEC7EA66FB" modified="2005-11-22" version="1">MPRVKRGFKARRRRNKVLKLAKGYRGARSKLFRSATEAVDRALNYAFRDRKVKKRDFRALWITRINAASRLNGLSYSKLIHGLKKASVEIDRKVLADLAVSDPQGFSEIASVAKTQI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VS7</accession>
    <name>RL35_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmI</name>
        <name type="ordered locus">Gmet_1413</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL35 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511654.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VS7"/>
    <dbReference type="SMR" id="Q39VS7"/>
    <dbReference type="STRING" id="269799.Gmet_1413"/>
    <dbReference type="EnsemblBacteria" id="ABB31647">
        <property type="protein sequence ID" value="ABB31647"/>
        <property type="gene ID" value="Gmet_1413"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1413"/>
    <dbReference type="eggNOG" id="COG0291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169643_4_3_7"/>
    <dbReference type="OMA" id="PKIKTHR"/>
    <dbReference type="OrthoDB" id="2046660at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.410.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00514">
        <property type="entry name" value="Ribosomal_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021137">
        <property type="entry name" value="Ribosomal_L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018265">
        <property type="entry name" value="Ribosomal_L35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001706">
        <property type="entry name" value="Ribosomal_L35_non-mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037229">
        <property type="entry name" value="Ribosomal_L35_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33343">
        <property type="entry name" value="PTHR33343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01632">
        <property type="entry name" value="Ribosomal_L35p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00064">
        <property type="entry name" value="RIBOSOMALL35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143034">
        <property type="entry name" value="SSF143034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00001">
        <property type="entry name" value="rpmI_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00936">
        <property type="entry name" value="RIBOSOMAL_L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000258684" description="50S ribosomal protein L35">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="65" mass="7411" checksum="0DF190B6C8EFB35C" modified="2005-11-22" version="1">MPKIKTNRGAAKRFRKTASGKIKRNSAFTSHILTSKTRKRKRQLRSSSIVAAVDQKNIARLIPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W05</accession>
    <name>Q39W05_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1334"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31569">
        <property type="protein sequence ID" value="ABB31569"/>
        <property type="gene ID" value="Gmet_1334"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1334"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_2_1_7"/>
    <dbReference type="OMA" id="HANNQVG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="300" mass="34705" checksum="996C80B083C7527B" modified="2005-11-22" version="1">MTNNSTKVCVLLATYNGTKWCLDQVKSILNQEDVNLEVFVSDDLSSDSTTDLLALLNDSRIHILASSYKFGSACQNFFRLVRDVDFSEYDYIAFADQDDLWNPNKLSYSIEQLNAHCADAFSSNVTAFWPDGRARLIVKDQPQREWDFLFESAGPGCTFVLTKKLACNLANFLHNNYEKTKGVALHDWFTYAFARSNSYSWWIDSQPTMMYRQHESNEFGVNSGVTAALSRFRKTSNGWYRNQVILIGDLVGAEDSWPIKRMRRFSLLDRMLLLFNVFAFRRSFRDRIALFFLLLLPQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W07</accession>
    <name>Q39W07_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514695.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1332"/>
    <dbReference type="EnsemblBacteria" id="ABB31567">
        <property type="protein sequence ID" value="ABB31567"/>
        <property type="gene ID" value="Gmet_1332"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1332"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_844016_0_0_7"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="329" mass="37958" checksum="B4150707EDEEB7D9" modified="2005-11-22" version="1">MKVIVNLYHIKSTNGLYFYALDYIKQLDGRILKILVRPKLYEHIINTFPALTVKICSWVSLVRELFSADETNMLIYTPTPHPMPFLNNQLIVMHDFYPFNYGKYSTLKKLLLKISLASSNCRVAYINKSEMLPSILSMGIEEKRCLFAPNRFPSKLDIETRSNYKRGAILKVALVGTDSPKKNYDELFHMIVDYNVTDKFIFYIYGHENKYYHDLCADFKSINISIINSDTVTLEQFFVNIDILVSVANHEGFGRPIAVALLLGVPCFLLERKVFKEFFDPGAIFYETVSEMVLEMISYTTKELPEVNFLPSSEYIMAYENALAVLSQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W32</accession>
    <name>Q39W32_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoacid:ferredoxin oxidoreductase, ferredoxin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vorD</name>
        <name evidence="5" type="ordered locus">Gmet_1306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31542.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512060.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1306"/>
    <dbReference type="EnsemblBacteria" id="ABB31542">
        <property type="protein sequence ID" value="ABB31542"/>
        <property type="gene ID" value="Gmet_1306"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1306"/>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_5_3_7"/>
    <dbReference type="OMA" id="CARMCPD"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31542.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="67" mass="7177" checksum="896FF3FC7D91C86B" modified="2012-10-31" version="2">MAYIEIDESRCKGCGLCTLACSRKLVIMSDTANKQGYVTAVATHQDQCTGCSLCAEICPDVAIVVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W51</accession>
    <name>Q39W51_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphotransferase system, mannose-type, protein IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1287</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365798.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1287"/>
    <dbReference type="EnsemblBacteria" id="ABB31523">
        <property type="protein sequence ID" value="ABB31523"/>
        <property type="gene ID" value="Gmet_1287"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1287"/>
    <dbReference type="eggNOG" id="COG2893">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123235_0_1_7"/>
    <dbReference type="OMA" id="RNITCAS"/>
    <dbReference type="OrthoDB" id="2008912at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00006">
        <property type="entry name" value="PTS_IIA_man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004701">
        <property type="entry name" value="PTS_EIIA_man-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036662">
        <property type="entry name" value="PTS_EIIA_man-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033887">
        <property type="entry name" value="PTS_IIA_man"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03610">
        <property type="entry name" value="EIIA-man"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53062">
        <property type="entry name" value="SSF53062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51096">
        <property type="entry name" value="PTS_EIIA_TYPE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTS EIIA type-4" evidence="3">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="13801" checksum="B2A13D503BB4D286" modified="2005-11-22" version="1">MIGLVLVTHAGLAEELLRGAEMIVGPIESAETIGIRPGDQADAIMERIAEAVKRVSVDGALIMTDMFGGTPSNMSLSFLEADRIEVLTGVNLPMVIKFAAERDRIAVAELATSLKECGRESIAVAGDYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W89</accession>
    <name>Q39W89_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipopolysaccharide export system permease protein LptF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lptF</name>
        <name evidence="11" type="ordered locus">Gmet_1249</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31485.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365791.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1249"/>
    <dbReference type="EnsemblBacteria" id="ABB31485">
        <property type="protein sequence ID" value="ABB31485"/>
        <property type="gene ID" value="Gmet_1249"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1249"/>
    <dbReference type="eggNOG" id="COG0795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028799_3_0_7"/>
    <dbReference type="OMA" id="ELQWRIA"/>
    <dbReference type="OrthoDB" id="1558251at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030922">
        <property type="entry name" value="LptF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005495">
        <property type="entry name" value="LptG/LptF_permease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33529">
        <property type="entry name" value="PTHR33529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03739">
        <property type="entry name" value="LptF_LptG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04407">
        <property type="entry name" value="LptF_YjgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31485.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="389" mass="43607" checksum="90005BE40ECFC1C1" modified="2012-10-31" version="2">MTSILFRYIFKETAVPFVLGMAVFTFVLLMGRLLKLAEMVFAKGVPFLDVCRLILYMLPSFLLVAIPMAFLLAVLLSFGRLSADSEVTAMKAGGVGLGSLLTPVFTFAVLAYLVTTFITVFALPWGNTSFKRFLYEVIESRAATTIKEKVFIDDFPGLVVYIDDYDQTSHQISGILIHDERNPDEPMTIFASTGIIAAAPEEKNVRLHLVNGSIHRGIDPGGYRLVEFRSYDLHVDLRQNAKKNQFDEQDMTLKQLIASRGNRQNNEKFRRDVSIELHKRFALPFACIVFAMVGVPLGIQNQRSGRAGGFSAGIIILMLYYVVMSAGKTIAEKEILPIPLAVWLPNVFFTAFGVYLLRLAATERPFPLIERGRTLIGEAREWLHRRKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WB6</accession>
    <name>Q39WB6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix XRE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1221</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31458.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512148.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1221"/>
    <dbReference type="EnsemblBacteria" id="ABB31458">
        <property type="protein sequence ID" value="ABB31458"/>
        <property type="gene ID" value="Gmet_1221"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1221"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_17_5_7"/>
    <dbReference type="OMA" id="PGNSVIQ"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31458.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="143" mass="16151" checksum="EBE1A0587FFD2FCF" modified="2012-10-31" version="2">MSCDIGRELKRLRKDRELTQKDLAARVDGGLDYTYIGKIERGEQLPSLKMLMGLSAALGVPVSHFFQEESPATNSPLRMADSDVKSMELHKELRQLHPDDIPLVVDIVRVLNRHRKAERKRAYQPATEALPLAAEDGPSYRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WM5</accession>
    <name>Q39WM5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Bidirectional NAD-reducing hydrogenase, diaphorase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hoxE</name>
        <name evidence="8" type="ordered locus">Gmet_1109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513765.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1109"/>
    <dbReference type="EnsemblBacteria" id="ABB31349">
        <property type="protein sequence ID" value="ABB31349"/>
        <property type="gene ID" value="Gmet_1109"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1109"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_7"/>
    <dbReference type="OMA" id="LRPVYCL"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028431">
        <property type="entry name" value="NADP_DH_HndA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43342:SF2">
        <property type="entry name" value="PTHR43342:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="205" mass="22213" checksum="74AA1949CE960EE4" modified="2005-11-22" version="1">MGRTSRFTLQSSEITPESISQTPSTPTELTSDPRFQAVERTIKQFQCRADALIEVLHVAQEAFGYLSDELMAHVARQLKIPFSQVYGVATFYHFFSLEPRGAHTCVVCTGTACYVKRSAEILVRLEQEFRVKAGKTTEDGGLTLSTIRCLGSCGQAPVMVLDGETVGQCTPDSAVVAVKALQESGRPRPNDEGGVRQEGGGGRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WS2</accession>
    <name>Q39WS2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Molybdenum cofactor guanylyltransferase</fullName>
                <shortName evidence="6">MoCo guanylyltransferase</shortName>
                <ecNumber evidence="6">2.7.7.77</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="6">GTP:molybdopterin guanylyltransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="6">Molybdopterin-guanine dinucleotide synthase</fullName>
                <shortName evidence="6">MGD synthase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="6">Molybdopterin guanylyltransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="6">Mo-MPT guanylyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="5">Sulfur carrier protein FdhD</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="5" type="primary">fdhD</name>
        <name evidence="6" type="synonym">mobA</name>
        <name evidence="8" type="ordered locus">Gmet_1062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo-MPT) cofactor (Moco or molybdenum cofactor) to form Mo-molybdopterin guanine dinucleotide (Mo-MGD) cofactor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H(+) + Mo-molybdopterin = diphosphate + Mo-molybdopterin guanine dinucleotide</text>
            <dbReference type="Rhea" id="RHEA:34243"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:71310"/>
            <dbReference type="EC" id="2.7.7.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">The N-terminal domain determines nucleotide recognition and specific binding, while the C-terminal domain determines the specific binding to the target protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FdhD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MobA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.77" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513238.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39WS2"/>
    <dbReference type="STRING" id="269799.Gmet_1062"/>
    <dbReference type="EnsemblBacteria" id="ABB31302">
        <property type="protein sequence ID" value="ABB31302"/>
        <property type="gene ID" value="Gmet_1062"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1062"/>
    <dbReference type="eggNOG" id="COG0746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569569_0_0_7"/>
    <dbReference type="OMA" id="CEIFPEV"/>
    <dbReference type="OrthoDB" id="650445at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061603">
        <property type="term" value="F:molybdenum cofactor guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097163">
        <property type="term" value="F:sulfur carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02503">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00187">
        <property type="entry name" value="FdhD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00316">
        <property type="entry name" value="MobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003786">
        <property type="entry name" value="FdhD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013482">
        <property type="entry name" value="Molybde_CF_guanTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30592">
        <property type="entry name" value="PTHR30592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02634">
        <property type="entry name" value="FdhD-NarQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00129">
        <property type="entry name" value="fdhD_narQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="7">
        <location>
            <begin position="276"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine persulfide intermediate" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="279"/>
            <end position="281"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="479" mass="51660" checksum="6E5FD955F37E428B" modified="2005-11-22" version="1">MKTIHIYTNGRFEEKQSGIVREFPLVLHVNGREIATLISSPHDLRFLVAGFLRNQGFVERAEDFHMLAVCDDFGIANARIRGELPERLKPVLTSGCGTGVTFTLETPKIPPPLALPAITTDAVFRLMEELARRADNYRSHGGIHSAAVGDGEGNLLLFAEDIGRHNTLDRIAGEALFKGIDLAGTILVTSGRVSTEMAAKCARLGIALIASRTSATDMAVKMCDEAGIPLIGYVRGGKFTVYAHHERLAMAPPVGAIHELPLPASAQGRRIPGITGVILAGGQSRRMGSNKALLPYKGGRFIEAIHRQLAEIFDEVLLVTNNPEQYDFLPCRKVADIHPGMGALAGIHAGLHHAANPAAFMVACDMPYLNSDLIRHLATLADPGGVLIPESPAGLEPLHAVYGKGCLAAIETTLLSGERRIVSFFGRTNVNRVNAEQVALFDPDYATFSNINTPVDYYRLRDGERDELDAALGADRIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WV6</accession>
    <name>Q39WV6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sensor protein QseC</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Gmet_1027</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513198.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1027"/>
    <dbReference type="EnsemblBacteria" id="ABB31268">
        <property type="protein sequence ID" value="ABB31268"/>
        <property type="gene ID" value="Gmet_1027"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1027"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_7"/>
    <dbReference type="OMA" id="LANAHWA"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013727">
        <property type="entry name" value="2CSK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08521">
        <property type="entry name" value="2CSK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="14">
        <location>
            <begin position="191"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="252"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB31268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="477" mass="51638" checksum="2243334868442EBD" modified="2005-11-22" version="1">MRGMPNSIQGRLFLSIVTFTSLLFIAVGVFIYREVNGIVIGAVDRTLHSKVQVITGLLHEEDHTIELELEEVVSGEYSIPRSGHYFKVMMNGKLLAASPSLVNDSFDLGAGAPEPSDEELGEDISTSVGPAGEPIRVLRHNLSAFGMTFTVFVAESLSDSLDMISTFRRFLLLVIPSGIVIASLICLWIARQSLAPLAIFSGRIETITHKNLGERIDAESETRELAGLAGSFNKMLDRLQKVFESEKRLIADASHELKTPVSVIKVQCDVVLQRERTPEEYIDAIQTIRTVSDTISMIVRDLLSLARLDSGVFSQGFAVVSLNACIGRALDMTKPFAEKRHLQVIAALGDDVAILGNGESLTEAFLNILENGVKYNREYGMLEITVVGSGAQAVVSIKDTGVGMEKEDQARIFDRFYRADTARNSDGTGLGLSIAKAIIDAHGGAITLASEPGKGATFTVILPVNHHTVEKGILPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WW5</accession>
    <name>Q39WW5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513188.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1017"/>
    <dbReference type="EnsemblBacteria" id="ABB31259">
        <property type="protein sequence ID" value="ABB31259"/>
        <property type="gene ID" value="Gmet_1017"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1017"/>
    <dbReference type="HOGENOM" id="CLU_117570_0_0_7"/>
    <dbReference type="OrthoDB" id="2095181at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="165"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="201" mass="22990" checksum="97D5C2DFCA3D3B88" modified="2005-11-22" version="1">MMAITFRTWVRAELEAVWAVVLDSVENPQRYMSDVEAVRVLERLQGGITKELTIRGMEYAPGCFDFFVFERGTLKKIKSTENDNVCASGVFDSFVFESSIIREVTVRGVPYRERIRISNKERKIHRELIDHPACSGKIIVKAVPCSVQNPMAPVDLQFFLELKSMKGAKEETEEMTGEIKKEQQRLKEKAEELEASALRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X19</accession>
    <name>Q39X19_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type II secretion system protein H</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">General secretion pathway protein H</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fimU</name>
        <name evidence="13" type="ordered locus">Gmet_0963</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514357.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0963"/>
    <dbReference type="EnsemblBacteria" id="ABB31205">
        <property type="protein sequence ID" value="ABB31205"/>
        <property type="gene ID" value="Gmet_0963"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0963"/>
    <dbReference type="eggNOG" id="COG4970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1584125_0_0_7"/>
    <dbReference type="OrthoDB" id="1857712at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022346">
        <property type="entry name" value="T2SS_GspH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12019">
        <property type="entry name" value="GspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="GspH" evidence="12">
        <location>
            <begin position="46"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="170" mass="18181" checksum="2714974A79FFEBDC" modified="2005-11-22" version="1">MISKAHNNRGFSLIELIVTVAIIGILAGIGTVMYLRELPLYRLKDATRLLFSDIQSARICALRNGAPCTLEQFPTNGNGYRIVQNGTVLKTIDLGGFTGVSFGSLNADAPAPDSGTFTSNQLVIQPSGIASTGNFYLKDNRNPADGRRIAVNAAGRPIISSWDSSTSTYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X83</accession>
    <name>Q39X83_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Pyrroline-5-carboxylate reductase</fullName>
            <shortName evidence="2">P5C reductase</shortName>
            <shortName evidence="2">P5CR</shortName>
            <ecNumber evidence="2 3">1.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">PCA reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 6" type="primary">proC</name>
        <name evidence="6" type="ordered locus">Gmet_0899</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-proline + NAD(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>L-proline + NADP(+) = 1-pyrroline-5-carboxylate + 2 H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15893"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 3">Amino-acid biosynthesis; L-proline biosynthesis; L-proline from L-glutamate 5-semialdehyde: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.2" evidence="2 3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513045.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0899"/>
    <dbReference type="EnsemblBacteria" id="ABB31141">
        <property type="protein sequence ID" value="ABB31141"/>
        <property type="gene ID" value="Gmet_0899"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0899"/>
    <dbReference type="eggNOG" id="COG0345">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042344_3_1_7"/>
    <dbReference type="OMA" id="VVRVMTN"/>
    <dbReference type="OrthoDB" id="1349288at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00361"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PTHR11645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00521">
        <property type="entry name" value="P5CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F420_oxidored" evidence="4">
        <location>
            <begin position="6"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="P5CR_dimer" evidence="5">
        <location>
            <begin position="163"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="270" mass="27645" checksum="D2B69205E333705D" modified="2005-11-22" version="1">MLKGCRVGFIGGGNMAEAIIRGLLAGGVTAAELVVAEPMAERREFLRETYGIDARADNGEVATMTDALIVAVKPQVFRGMAAALGAAGFAGKLVISIMAGISINGIEEVCGDSSRVIRVMPNTPALVLEGASALSRGKNATDDDLFFAQGIFELVGTTCVVDEKLMDAVTGLSGSGPAYVFMFIEALSDAGVKNGLPRDVATRLAAQTVLGSARLLLETGDHPGVLKEKVTSPGGTTIAGVAALERGSFRGTVMAAVDAATARSAELGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XH0</accession>
    <name>Q39XH0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0812</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514399.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0812"/>
    <dbReference type="EnsemblBacteria" id="ABB31054">
        <property type="protein sequence ID" value="ABB31054"/>
        <property type="gene ID" value="Gmet_0812"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0812"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="ILCDQRM"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="145"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="453" mass="50615" checksum="9B6F483B5CB05290" modified="2005-11-22" version="1">MKERTRILLIDDEESGREALTLILRNAGHHVTGAASGREAAQHLARDKFDIIITDLFLPDTNGIDILKDVKNDSPLTEVILITGHASAETAVRAMKEGAYDYITKPLNIDELRIIIAKAVEKHQLLSENVYLRKQLRDKFEFANIIGASPAMQQVFALMKRIVKTDSTVLIAGESGTGKEIVAKAIHFNGSRRERPFIAVHCGAIPENLLESELFGYVKGAFTGAVRDKIGKFEAANGGTIFLDEIGTMPLQLQTKLLRVLQEQEVERVGSTRPIKIDVRIISATNLDLAEEVKKGTFREDLYYRLNVIPLGLPPLRDRVEDILPLAKHFLAKYCKEMQRRRMTLATEAVEALEGYRWGGNVRELENVMERVVALTEADTITLHDLPPNIREESLTRVTERGVDLVKVIAEIERSMITDALALTDGVKARAAALLNLNRTTLVEKMRRLGMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XN4</accession>
    <name>Q39XN4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEP motif-containing protein, putative exosortase substrate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514465.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0748"/>
    <dbReference type="EnsemblBacteria" id="ABB30990">
        <property type="protein sequence ID" value="ABB30990"/>
        <property type="gene ID" value="Gmet_0748"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0748"/>
    <dbReference type="HOGENOM" id="CLU_1178861_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223605" evidence="1">
        <location>
            <begin position="21"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="235" mass="24843" checksum="AC34952FF813365F" modified="2005-11-22" version="1">MKRILFALALVASVATSGWAITYTGSLASSPGGGLLATLDWAGITTAGAPNSSLSWTVDDTTNTGLWTYNYIWTGTRKGLSHIVIEVSDTFTKDNIMQISSGYDGDAPKTYSPSDASNDGLPADIWGIKWNAEGTVFNFSIVTDREPMWGDVYARDGKTGGSDVYAYNTGFGFDTAAVIADGNAFDQATGRAWALVPDTENGGGGQQEVVPEPGTIMLLGTGLIGLALYGRRRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XP4</accession>
    <name>Q39XP4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase DUF294, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0738</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514455.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0738"/>
    <dbReference type="EnsemblBacteria" id="ABB30980">
        <property type="protein sequence ID" value="ABB30980"/>
        <property type="gene ID" value="Gmet_0738"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0738"/>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027866_2_0_7"/>
    <dbReference type="OMA" id="QDYLIVY"/>
    <dbReference type="OrthoDB" id="301791at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018821">
        <property type="entry name" value="DUF294_put_nucleoTrafse_sb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005105">
        <property type="entry name" value="GlnD_Uridyltrans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03445">
        <property type="entry name" value="DUF294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10335">
        <property type="entry name" value="DUF294_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF294" evidence="1">
        <location>
            <begin position="89"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="DUF294_C" evidence="2">
        <location>
            <begin position="258"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="403" mass="45648" checksum="A50966D950030F0A" modified="2005-11-22" version="1">MHNDIIQTAVAETMARINAFVRVLEQDEIPLILNRLKEEVDHEIALTGQIAGRRRELMARVKGETDYGALREIHDELNGLELERFLKIQSVTALHASCTEYRDVLAGRALELVEQEMAATGKGSPPRSYALCSMGSDGREEQTLITDQDYLIVYGDEGGEAADQWFREFSETLVERMAEMGFKKCTGDIMPSNPTWRGSYGQWKKKLLAIVRYEYEDYAKNLMDLIVLSDARHVAGDKDLANDLVGLIRGLEQDYFQVLWGMAKAATEMKLALGFLNRLWTEGSGEHKGEFNLKLLAWAPLVMNVRILAINQGIPATNTVRRIELLQKEGSFSATFAQGLVDAYTTLTKHRILLQIKVIKGIDKSSYYLNPYTLPADEREEIRQALIKIEDLQRTIHTNFSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XS1</accession>
    <name>Q39XS1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Agmatine deiminase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aguA</name>
        <name evidence="2" type="ordered locus">Gmet_0711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514616.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0711"/>
    <dbReference type="EnsemblBacteria" id="ABB30953">
        <property type="protein sequence ID" value="ABB30953"/>
        <property type="gene ID" value="Gmet_0711"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0711"/>
    <dbReference type="eggNOG" id="COG2957">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037682_0_0_7"/>
    <dbReference type="OMA" id="WCRDHGP"/>
    <dbReference type="OrthoDB" id="771174at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009446">
        <property type="term" value="P:putrescine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007466">
        <property type="entry name" value="Peptidyl-Arg-deiminase_porph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31377">
        <property type="entry name" value="PTHR31377"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04371">
        <property type="entry name" value="PAD_porph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="351" mass="38598" checksum="8327951DA2BA5E83" modified="2005-11-22" version="1">MITRLPAEWEEQDGVLLAWPHAESDWLPWLPMVELVFAQIVKEIAHFEAVLLVAAEGERTSAILSAAGASMERVRIVEIPTNDTWARDFGPLTVERDGNPVLLDFGFNGWGLKFAADRDNLITGRLHRTGAFGNAALETVGLILEGGSIESDGNGTILTTAECLLNPNRNPHLSQEQIEISLKEQFGADRILWLENGWLAGDDTDSHIDTLARLAPDDTIVYVRCDDAADEHYPALFLMEKELKAMRTSEGSPYRLIPLPWPRPCHDEDGERLPATYANYLVINGAVLVPTYGDPGDDAALAAIGQAFPGREIIGIDCRPLILQHGSLHCVTMQLPKGTLAPEPRNVTREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XS6</accession>
    <name>Q39XS6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0706</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514098.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30948">
        <property type="protein sequence ID" value="ABB30948"/>
        <property type="gene ID" value="Gmet_0706"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0706"/>
    <dbReference type="eggNOG" id="ENOG50311G5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1265818_0_0_7"/>
    <dbReference type="OMA" id="FKSSWVE"/>
    <dbReference type="OrthoDB" id="1355909at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="218" mass="25374" checksum="86E5D5236CD656B6" modified="2005-11-22" version="1">MTDIPKSSGERFIERIMGELDPTSERFQVLETAKRFKSSWVELGDRLLAVSSRDLYKEWGYGSFEDYCTKEIRIKKETAQKLTLAYRFMEKNEPELMARREEPRPFPDYRSIDLLRQAREEKGFSDEEYADLRKSVVEQERSHPTVLKQFKEVAKTREEPVSDPSVPLKAALGAARRLDTALRGVEELPGDYREMVERLIASLEEELEGLQVVVEHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XT2</accession>
    <name>Q39XT2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sensor diguanylate cyclase/phosphodiesterase, HAMP and PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365712.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0700"/>
    <dbReference type="EnsemblBacteria" id="ABB30942">
        <property type="protein sequence ID" value="ABB30942"/>
        <property type="gene ID" value="Gmet_0700"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0700"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_49_7"/>
    <dbReference type="OMA" id="QYISASI"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="270"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="341"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="6">
        <location>
            <begin position="425"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="567"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="820" mass="90857" checksum="BD9F853C940AD9CF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XX3</accession>
    <name>Q39XX3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux pump, RND family, membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhG-1</name>
        <name evidence="5" type="ordered locus">Gmet_0659</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514267.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0659"/>
    <dbReference type="EnsemblBacteria" id="ABB30901">
        <property type="protein sequence ID" value="ABB30901"/>
        <property type="gene ID" value="Gmet_0659"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0659"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_6_3_7"/>
    <dbReference type="OMA" id="DAWAVFQ"/>
    <dbReference type="OrthoDB" id="1174564at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CusB_dom_1" evidence="3">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="32"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="335" mass="37013" checksum="718E1C22052F7197" modified="2005-11-22" version="1">MKKKVALIAILLLAVAAIAWFVTRRTGNDSSTVAVSGTIELTEVEVSFKIPGRVRERLVDEGELVKAGQVVARLDDDDLRLEVAQRERDTEAMAANLRELETGFRKEDIVRADAAVNRVKAETDRLKADFARQEALFRRDVISRRDYDAAKAAHESSQAALREAVAQQELMHRGPRKEQIDAARARFGQARETLELARTRLGYTTLAAPMAGLVLAKHVEPGEQVAAGTPIISVGDMPNTWMRAYIAETDLGRVKVGQKARVKSDTWPDRRYEGTVTFISPEAEFTPKSVQTEKERVKLVYRIKITIPNPAMELKPGMPVDAEIGTGDQGPGTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y44</accession>
    <name>Q39Y44_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0587</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512285.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0587"/>
    <dbReference type="EnsemblBacteria" id="ABB30830">
        <property type="protein sequence ID" value="ABB30830"/>
        <property type="gene ID" value="Gmet_0587"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0587"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061503_0_0_7"/>
    <dbReference type="OMA" id="PRINCIV"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="42"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="376" mass="41696" checksum="D0B467C243FB2579" modified="2005-11-22" version="1">MIRKVYHDFLLAKLKQDGVGWLARRARQYLLLHLSPLAGRALCGPVHGSLMVTRRCNCDCTMCDIPSKRRESAGTGGDELDTARLKEIIGEFARLGTPGLGFTGGEPLLRPDIYELLACSRHNGMITHLNTNGYFLDDTAARCIVDAGVESVNISLDGASPATHDRIRNCGGAFERATAAVERLHRLRRERGVPLRIKMVAVLSEANIDEAGDLAELSRELGADCIEFIPCQPLTGNGGDKATPDESFMKKVDRLVEYLLAMGRERGMVENSPAHLRLFRSSVAGVPSPVRCRAGYHSLLVDCHGDVFPCFPRMSWGRRAGNVRHGSLVDLWRSDGYQTHRDIASACRDCYLNCHLELNLLFDHKARGRFRRGSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YB1</accession>
    <name>Q39YB1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Arsenite efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arsB</name>
        <name evidence="5" type="ordered locus">Gmet_0520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512216.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0520"/>
    <dbReference type="EnsemblBacteria" id="ABB30763">
        <property type="protein sequence ID" value="ABB30763"/>
        <property type="gene ID" value="Gmet_0520"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0520"/>
    <dbReference type="eggNOG" id="COG0798">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022869_0_0_7"/>
    <dbReference type="OMA" id="CTAMVLM"/>
    <dbReference type="OrthoDB" id="1493959at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="PTHR43057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005508">
        <property type="entry name" value="Acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="316"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="350" mass="38768" checksum="A75B2703C07F44C2" modified="2005-11-22" version="1">MSEHVSRNLSFLDRWLTLWIFAAMALGVGLGYFIPGVEQFINRFQVGTTNIPIAAGLILMMYPPFAKVKYEEMPEVFRNKKILGLSLAQNWLIGPALMFVLAIAFLPDKPEYMVGLIMIGLARCIAMVIVWNELAKGNTEYAAGLVAFNSIFQVLFYSVYAWFFITVLPPLFGLSGSVVEVSIRQIAESVFIYLGIPCIAGALTRLVGVKLMGKERYHREVVPRIGPITLVALLFTIVVMFSLKGNLIVQLPLDVVRIAIPLLIYFIVMFLISFWMGKRLGADYTKTTTLAFTAASNNFELAIAVAVAVFGLNSGAAFAAVIGPLVEVPVMIGLVNVAFWFRRRWFATTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YT4</accession>
    <name>Q39YT4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0347</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512318.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0347"/>
    <dbReference type="EnsemblBacteria" id="ABB30590">
        <property type="protein sequence ID" value="ABB30590"/>
        <property type="gene ID" value="Gmet_0347"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0347"/>
    <dbReference type="HOGENOM" id="CLU_141547_0_0_7"/>
    <dbReference type="OMA" id="KPACCWE"/>
    <dbReference type="OrthoDB" id="1947398at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223469" evidence="1">
        <location>
            <begin position="24"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="16462" checksum="5E4183E824B60FE4" modified="2005-11-22" version="1">MHIIRRMVAVAVVMLAVAGPASARTARPADPGMAAEARQSLEDILDTWRDGNYELLYDRTSVSGRESREGFARKLAKASRRPACCWEKLQEVTVSARSGDTVTVRGRFGLDGGPGGTEYATRSVRLVREDGVWKASRADILSLAGEKRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YT7</accession>
    <name>Q39YT7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0344</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512315.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0344"/>
    <dbReference type="EnsemblBacteria" id="ABB30587">
        <property type="protein sequence ID" value="ABB30587"/>
        <property type="gene ID" value="Gmet_0344"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0344"/>
    <dbReference type="eggNOG" id="COG3864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038906_1_0_7"/>
    <dbReference type="OMA" id="AGVWVHE"/>
    <dbReference type="OrthoDB" id="801007at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025154">
        <property type="entry name" value="Put_metallopeptidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018698">
        <property type="entry name" value="VWA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09967">
        <property type="entry name" value="DUF2201"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13203">
        <property type="entry name" value="DUF2201_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2201_N" evidence="3">
        <location>
            <begin position="5"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2201" evidence="2">
        <location>
            <begin position="267"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="390" mass="43348" checksum="7DB17EF2CFF977FC" modified="2005-11-22" version="1">MPKRNIENAIVRMLKRKPFYGRFLLGLRREGGNGGHPLGVTVRDGVPTLAVNAPLFGAEPPQVQEGLLEHTIKHLIHLHMFRRKGRNNHDWDLACDLAINPSIEHLPADALLPRAFKLEEGLAAEEYYALLVDPFDTGSLKGYGTGNASRDSGGKKESGEDEEQSVATVDDHAIWDDADATPVRLAEEVVRGMVRDAYRACDGEVPADIRQVVAGMLAPSPIPWRQVLRQFVATAGRTGRQTTWMKEHRRFVHITPGTRKMRRLNLLIGIDVSDSTNSVELREAFAQELVRISRGRESTITVLYANSRIQRIDAFRGVASVVEIYEGGGFTDLRPVFSFARTMHPLPAAVIYLTDGIGPVPEPMEFPTLWVLTRDGEKPAPWGAEVRLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YY6</accession>
    <name>Q39YY6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0293</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514004.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0293"/>
    <dbReference type="EnsemblBacteria" id="ABB30538">
        <property type="protein sequence ID" value="ABB30538"/>
        <property type="gene ID" value="Gmet_0293"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0293"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072297_0_0_7"/>
    <dbReference type="OMA" id="APPRWGE"/>
    <dbReference type="OrthoDB" id="1431620at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223632" evidence="2">
        <location>
            <begin position="24"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="328" mass="39689" checksum="C3A76F030DDC2A26" modified="2005-11-22" version="1">MRKICCGVVLLWMLLCSVTSVPAQVSIGIGLPHVSIGINLPLYPDLVPVPGYPVYYAPRVAANYFFYDGLYWIYYDDDWYASYWYNGPWWIVEPDVVPVYILRIPVRYYRHPPPYFHRWRPDAPPRWGEHWGREWEHERRGWNKWKRGSAPPRAPLPVYQRQYSGDRYPTVEQQQAIRREHYRYQPRDKAVRQHFQPRGEKGAPATSQREQREERRMRAPEQQRGPRETLPVQRGKQEERRMRAPAQQREQSAPVPGQRERRQEERRMRAPEQQGGPSQRPPQQRQERRDIQRETPRPQEQRMQNREQPQKRGQQQEQRQMREEERGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="39" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YZ7</accession>
    <name>Q39YZ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0282</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30527">
        <property type="protein sequence ID" value="ABB30527"/>
        <property type="gene ID" value="Gmet_0282"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0282"/>
    <dbReference type="HOGENOM" id="CLU_2537768_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="83" mass="9538" checksum="0AC82930AF45885D" modified="2005-11-22" version="1">MDANLIESAGRQVNEQLVRPLYPSKEAFQKRRFYKGVRAIESLSDGSMIAQNFTHRRGPGGHILRRVRTLILGLADYRLDILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z10</accession>
    <name>Q39Z10_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0269</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513586.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0269"/>
    <dbReference type="EnsemblBacteria" id="ABB30514">
        <property type="protein sequence ID" value="ABB30514"/>
        <property type="gene ID" value="Gmet_0269"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0269"/>
    <dbReference type="eggNOG" id="ENOG5032TD0">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112039_3_0_7"/>
    <dbReference type="OMA" id="TIYVPVY"/>
    <dbReference type="OrthoDB" id="1716865at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021471">
        <property type="entry name" value="DUF3124"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11322">
        <property type="entry name" value="DUF3124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="17040" checksum="23631C47F31A5A00" modified="2005-11-22" version="1">MTARGWLVGMVVAAAAAVCGVGNAGAEVRLAKGQTLYVPVYSHVYTGDRALPFNLAATLGVRNLDPASPITVSRVDYHDSNGRLVKRFLAGPLKIPPQGSTSFYLKERDTSGGFGAHFIVVWESAREVNEPIVESVMIGARSGQGISFVSPAREIRPQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z47</accession>
    <name>Q39Z47_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513547.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0232"/>
    <dbReference type="EnsemblBacteria" id="ABB30477">
        <property type="protein sequence ID" value="ABB30477"/>
        <property type="gene ID" value="Gmet_0232"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0232"/>
    <dbReference type="eggNOG" id="ENOG5033SRH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_989592_0_0_7"/>
    <dbReference type="OMA" id="MAVFIEF"/>
    <dbReference type="OrthoDB" id="1181475at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="281" mass="31296" checksum="0DF10F54CD3B7B73" modified="2005-11-22" version="1">MNKKIHNMAVFIEFLVGSGLAIFFHWVLRHEEVAYVTFAVGVLLSLATWLLREDVEKSRDALIEQYREAHEIPAAIARICDAECHARATELMASTRRTLLMLEKGYIPLDDTEFYLEGAKLSDAATHSVKAVDPMTPGWGNRGTLLNFYQANLRALGQGVAITRIFVVNRDDLADPEVQKVLLAQHGDGVNVRVAFRDELPAATDINGRDTTGSCNFAIYDDQVVTDVFAQPGKYYGRKTAQHAEVERYQRLYELIGHSAHPLALDEGNLTISSEVYAIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z49</accession>
    <name>Q39Z49_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, DoxD family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DoxX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513545.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0230"/>
    <dbReference type="EnsemblBacteria" id="ABB30475">
        <property type="protein sequence ID" value="ABB30475"/>
        <property type="gene ID" value="Gmet_0230"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0230"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058421_2_1_7"/>
    <dbReference type="OMA" id="YFMAHAP"/>
    <dbReference type="OrthoDB" id="2025630at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032808">
        <property type="entry name" value="DoxX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07681">
        <property type="entry name" value="DoxX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="136" mass="14944" checksum="45E62A7C5C6C7C4C" modified="2005-11-22" version="1">MKSFMSLYSSYCYALMRIVTGFLFLWHGSQKLFAFPIGMPGDVPAFLTYVAGPIELIGGFLVMIGLFTHWAAFITSGEMAVAYWMVHGTTALLPIQNKGELAVLYCFAFLFIASQGGGIWSIDSSMHGARRKAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z56</accession>
    <name>Q39Z56_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Peptide methionine sulfoxide reductase MsrA</fullName>
                <shortName evidence="7">Protein-methionine-S-oxide reductase</shortName>
                <ecNumber evidence="7">1.8.4.11</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Peptide-methionine (S)-S-oxide reductase</fullName>
                <shortName evidence="7">Peptide Met(O) reductase</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">Peptide methionine sulfoxide reductase MsrB</fullName>
                <ecNumber evidence="6">1.8.4.12</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="6">Peptide-methionine (R)-S-oxide reductase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="7" type="primary">msrA</name>
        <name evidence="6" type="synonym">msrB</name>
        <name evidence="9" type="ordered locus">Gmet_0222</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 6">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12314"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:45764"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MsrB Met sulfoxide reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="7"/>
    <dbReference type="EC" id="1.8.4.12" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512811.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0222"/>
    <dbReference type="EnsemblBacteria" id="ABB30468">
        <property type="protein sequence ID" value="ABB30468"/>
        <property type="gene ID" value="Gmet_0222"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0222"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0229">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_7_2_7"/>
    <dbReference type="OMA" id="FWGVEYH"/>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033743">
        <property type="term" value="F:peptide-methionine (R)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01400">
        <property type="entry name" value="MsrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028427">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002579">
        <property type="entry name" value="Met_Sox_Rdtase_MsrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10173">
        <property type="entry name" value="PTHR10173"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01641">
        <property type="entry name" value="SelR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="SSF51316"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00357">
        <property type="entry name" value="TIGR00357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51790">
        <property type="entry name" value="MSRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MsrB" evidence="8">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="311" mass="35135" checksum="06B3251B5039EB6C" modified="2005-11-22" version="1">MTARKYSDEELKQRLTPLQYRVTRKSGTEPPFDNTYWNEHREGLYVDIVSGEPLFSSRDKFDSGTGWPSFTRPVAPNSVKEETDIGFGTVRTEVRSKEADSHLGHLFTDGPRDKGGLRYCVNSAALRFIPVDDLEKEGYGSYLPLFGRKAPAAAVKQVATLAGGCFWGMQDLLRKQPGVIATEVGYTGGSVPNATYENHEGHAEAVRIEFDPTKTSYEALLRFFFRMHDPTTLNRQGNDIGSSYRSAIFYHDAEQKRIAEKVKAEVDASGKWKRPVVTEIVPAGPWWRAEEYHQDYLVKNPGGYTCHWVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZE4</accession>
    <name>Q39ZE4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514136.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0131"/>
    <dbReference type="EnsemblBacteria" id="ABB30380">
        <property type="protein sequence ID" value="ABB30380"/>
        <property type="gene ID" value="Gmet_0131"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0131"/>
    <dbReference type="eggNOG" id="ENOG5033C1K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067281_1_0_7"/>
    <dbReference type="OMA" id="WAYVTRE"/>
    <dbReference type="OrthoDB" id="2047098at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024447">
        <property type="entry name" value="YXWGXW_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12779">
        <property type="entry name" value="WXXGXW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223532" evidence="1">
        <location>
            <begin position="22"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="213" mass="24851" checksum="42EEDDD0AC9A789B" modified="2005-11-22" version="1">MTSKIIASIACLAALTGTAHAGNVDFSIGINLGNRPVAVYEPVYAPAPPPVYAPAPPVRYEPVYASAPRPVYVPAPPPVVIAEPPEFVLSPSLGFYVAIGTPYDLFYAGNRYYLSRNGVWYNGASYQGPWTTVTYRSLPRELRRYPVATIRYQRDRDYRRWCDDDHDQWRSFRPERERREIRQDEKARWREAKWREKEWRKHGRDRWDDDDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZG0</accession>
    <name>Q39ZG0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phospholipase, patatin family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0115</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514120.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0115"/>
    <dbReference type="EnsemblBacteria" id="ABB30364">
        <property type="protein sequence ID" value="ABB30364"/>
        <property type="gene ID" value="Gmet_0115"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0115"/>
    <dbReference type="eggNOG" id="COG1752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047251_3_0_7"/>
    <dbReference type="OMA" id="ETMKDAH"/>
    <dbReference type="OrthoDB" id="373926at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="3">
        <location>
            <begin position="18"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="49"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="285" mass="30816" checksum="EDC7CC99F3948C73" modified="2005-11-22" version="1">MPNHHTMSPGPSNGPVTLMFIGGGSRCPAFIGALKAVEELRIPVGKIIGASGGSIVAALYAAGYSPDELHRLSLDTDIGAFRDFSPRGALAGMGVCRGDALERWLDEKLGGKHLGDGLRIPLGIVATDILNHTPHLLCGDNHPDLKVSAAVRFSMGIPLVFAWKKYSHRGRDYVFIDGSLMAGIIEGQCADAGRTLTIKTFAKRSISRPASSVLSLRRYGSDLLSIFYGAMDREFLKGGRWKDTITIHCGTVSPLTFSLSSAEKEFLFEQGYHQVAKYLRYKGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZP8</accession>
    <name>Q39ZP8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513792.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0026"/>
    <dbReference type="EnsemblBacteria" id="ABB30276">
        <property type="protein sequence ID" value="ABB30276"/>
        <property type="gene ID" value="Gmet_0026"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0026"/>
    <dbReference type="eggNOG" id="COG2952">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187465_0_0_7"/>
    <dbReference type="OMA" id="EWDILYR"/>
    <dbReference type="OrthoDB" id="1883396at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007463">
        <property type="entry name" value="DUF507"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04368">
        <property type="entry name" value="DUF507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="90" mass="10583" checksum="B228618BCC89CF26" modified="2005-11-22" version="1">MSISEDRISHLAHRIQDRLWKDDLADFPDERRSLQCIKEAISSFFAVTGEVDAAVRKKLASYAQAKVPGSREYEVLYQKFYQEEMAKRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZQ1</accession>
    <name>Q39ZQ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor protein, DUF3365, HAMP and PAS domain-containing, heme-binding</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0023</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513789.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0023"/>
    <dbReference type="EnsemblBacteria" id="ABB30273">
        <property type="protein sequence ID" value="ABB30273"/>
        <property type="gene ID" value="Gmet_0023"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0023"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_658503_0_0_7"/>
    <dbReference type="OMA" id="GHYSYNY"/>
    <dbReference type="OrthoDB" id="814432at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="231"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="289"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="408" mass="46294" checksum="FEA5A7598716AFA6" modified="2005-11-22" version="1">MSWFANLKISTKFNIILSLLLVFVFLAAAFFVYHRERALIDRIAVDNARSIARQIIETRDYISSVVKGEPNENYNLVPQVVATNVAKRLTRGSDYYVRQVSLRYRNPDNRPDPYEEEMLKLFAAKKSTETYRIVRTDKEQSFRYMLSMVAEKSCLECHGRYEDAPPFVRARFPKGHFSYNYQVGEVIGAVSVSIPLADLYREAGTDFRLDLATRGLTFCLIIFVMGFLVRRAIIDPLRQVSASITHVAATGSFGDRIPQRSRDEIGELVAAFNGMMEELDLKTRQRLESEDRYRNVLEMAQSAIVTFLADGKLIITNRRAEDLFGLPKGELLGASIYTFLADGDGVREGISAYLRDGTGGLVGETTSRKIRDIRGRITEVEMALSVSRSDHNPLFTAILREHNQHSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZR5</accession>
    <name>Q39ZR5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_0009</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513774.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0009"/>
    <dbReference type="EnsemblBacteria" id="ABB30259">
        <property type="protein sequence ID" value="ABB30259"/>
        <property type="gene ID" value="Gmet_0009"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0009"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_7"/>
    <dbReference type="OMA" id="HHGRIFY"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029150">
        <property type="entry name" value="dCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14827">
        <property type="entry name" value="dCache_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="326"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="415"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="542"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="763" mass="84260" checksum="3D00DCD85DA8F3AB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>J7LWC6</accession>
    <name>J7LWC6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3615</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFR42835">
        <property type="protein sequence ID" value="AFR42835"/>
        <property type="gene ID" value="Gmet_3615"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3615"/>
    <dbReference type="HOGENOM" id="CLU_2734273_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="71" mass="7853" checksum="207BE37467BC109E" modified="2012-10-31" version="1">MRTLNSLHRHNLKNIALWRVGRCRAMVCPARSTRSLSGAISDALRGICSAGKQLIHTINNMACGQAINPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PR8</accession>
    <name>Q39PR8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protoporphyrinogen oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hemY</name>
        <name evidence="8" type="ordered locus">Gmet_3551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Porphyrin-containing compound metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33756.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513707.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3551"/>
    <dbReference type="EnsemblBacteria" id="ABB33756">
        <property type="protein sequence ID" value="ABB33756"/>
        <property type="gene ID" value="Gmet_3551"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3551"/>
    <dbReference type="eggNOG" id="COG1232">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009629_3_0_7"/>
    <dbReference type="OMA" id="WFDQWFG"/>
    <dbReference type="OrthoDB" id="630753at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amino_oxidase" evidence="7">
        <location>
            <begin position="11"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33756.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="469" mass="50682" checksum="14329FC662DACDA2" modified="2012-10-31" version="2">MKKVIVVGGGISGLATAFELRNKGAEAGIELDVTLLEKEERVGGKIWSIKEEGYLCEWGPNGFLDSKPQTLDLCRDLGASERLLRSNDNARKRFIYTGGVLNRLPENGPTFLKSSLISWPGKLRLAMEPFISKRTDGTDETLASFGRRRLGEEALQKLISPMVSGIFAGDPETMSLRSCFPRIAELEDEYGSLIKAMIKLAKKKKQEAAQGKAVSSAAGPGGVLTSFRWGIQELTDILAEQLGSATVVTGQPVTGLTRGSSVPWRLKTPTVDIDADVVILASPAHATAGIVSGVDAAMAQVLGEIPYASMTVVCFGFERERIAYDLNGFGYLIPKDEGMNTLGTLWDSSIFENRAPEGKVLLRSMLGGACFPEYVKLSDAEVMQRVKADLKATMGITADPSFIRIFRHPQAIPQYTVGHGKRLAALQERSSALPGLFLTGNSYRGIGLNDCATAANRTTDEVVAYLKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q39</accession>
    <name>Q39Q39_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, ATP-binding/membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_3423</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33635.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366191.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3423"/>
    <dbReference type="EnsemblBacteria" id="ABB33635">
        <property type="protein sequence ID" value="ABB33635"/>
        <property type="gene ID" value="Gmet_3423"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3423"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_7"/>
    <dbReference type="OMA" id="LGIMLWG"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="9"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="326"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33635.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="574" mass="62585" checksum="7F050CEEF987033C" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q70</accession>
    <name>Q39Q70_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ordered locus">Gmet_3392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512618.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3392"/>
    <dbReference type="EnsemblBacteria" id="ABB33604">
        <property type="protein sequence ID" value="ABB33604"/>
        <property type="gene ID" value="Gmet_3392"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3392"/>
    <dbReference type="eggNOG" id="COG0163">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074522_0_0_7"/>
    <dbReference type="OMA" id="FERWNGW"/>
    <dbReference type="OrthoDB" id="1384786at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="5"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="102"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="206" mass="21668" checksum="0D3B3C78D1D394F1" modified="2005-11-22" version="1">MSGTVLVGITGASGSVYGLRLCEELLKAGKRVVVTASGAGIGVVREETNLDLSAGEEDAVARLRELFGASPEQLSFYGADNLFAPPASGSAAPDAMVVAPCSMGTLARIATGLSSTLLERCADVMVKEGRPLVIVPRETPLSAIHLENMLKLARLGVRVVPAMPAFYHRPRTLDDLVDFVVGKVLDTLGVHHELFTRWGVKAGTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QA5</accession>
    <name>Q39QA5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase-associated magnesium import membrane protein AtpZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">atpZ</name>
        <name evidence="2" type="ordered locus">Gmet_3357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33569.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366182.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3357"/>
    <dbReference type="TCDB" id="1.A.77.2.13">
        <property type="family name" value="the mg(2+)/ca(2+) uniporter (mcu) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33569">
        <property type="protein sequence ID" value="ABB33569"/>
        <property type="gene ID" value="Gmet_3357"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3357"/>
    <dbReference type="eggNOG" id="COG5336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137927_6_0_7"/>
    <dbReference type="OMA" id="DEWFGTK"/>
    <dbReference type="OrthoDB" id="2073672at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032820">
        <property type="entry name" value="ATPase_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09527">
        <property type="entry name" value="ATPase_gene1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33569.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="80" mass="9094" checksum="14FD2983CE7B0392" modified="2012-10-31" version="2">MDEEKRNLIKTVGLVSSMGISMALAIIIGVVIGRQLDKWFGTHPWFFFIFLFFGIAAGFRNIYIIAGREIRKDGEDNKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QK3</accession>
    <name>Q39QK3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3258</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512696.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3258"/>
    <dbReference type="EnsemblBacteria" id="ABB33471">
        <property type="protein sequence ID" value="ABB33471"/>
        <property type="gene ID" value="Gmet_3258"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3258"/>
    <dbReference type="eggNOG" id="COG2445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_1_0_7"/>
    <dbReference type="OMA" id="KFRNRIV"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="139" mass="16007" checksum="7121AB87542E585E" modified="2005-11-22" version="1">MVDREVAERLIGLLEGYVNDLRSVQSMSFAEYSADLRTKRFVERTLQIAIEACLDLGYHIIADEGLREPEDNRDVFKVLAEGGIINAKLLEALQPMASFRNLIVHDYGKIDDEIVFGILQRRLGDFTEYSRMIVRHMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QM2</accession>
    <name>Q39QM2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">K(+)-insensitive pyrophosphate-energized proton pump</fullName>
            <ecNumber evidence="9">7.1.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Membrane-bound proton-translocating pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate-energized inorganic pyrophosphatase</fullName>
            <shortName evidence="9">H(+)-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">hppA</name>
        <name evidence="10" type="ordered locus">Gmet_3239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>diphosphate + H(+)(in) + H2O = 2 H(+)(out) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="7.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="7.1.3.1" evidence="9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512678.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3239"/>
    <dbReference type="EnsemblBacteria" id="ABB33452">
        <property type="protein sequence ID" value="ABB33452"/>
        <property type="gene ID" value="Gmet_3239"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3239"/>
    <dbReference type="eggNOG" id="COG3808">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008743_3_1_7"/>
    <dbReference type="OMA" id="MATTAMQ"/>
    <dbReference type="OrthoDB" id="98036at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009678">
        <property type="term" value="F:pyrophosphate hydrolysis-driven proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01129">
        <property type="entry name" value="PPase_energized_pump"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004131">
        <property type="entry name" value="PPase-energised_H-pump"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31998">
        <property type="entry name" value="PTHR31998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03030">
        <property type="entry name" value="H_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001265">
        <property type="entry name" value="H+-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01104">
        <property type="entry name" value="V_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="573"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="599"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="site" description="Determinant of potassium independence" evidence="9">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="684" mass="70100" checksum="6DD5C8B37D70373B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QP1</accession>
    <name>Q39QP1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator, PilZ domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512659.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3220"/>
    <dbReference type="DNASU" id="3740975"/>
    <dbReference type="EnsemblBacteria" id="ABB33433">
        <property type="protein sequence ID" value="ABB33433"/>
        <property type="gene ID" value="Gmet_3220"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3220"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101334_0_0_7"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="233" mass="26155" checksum="6B2519387D66725C" modified="2005-11-22" version="1">MKPPSVLLVDDERFFLSVQRDFLKGSPIAVLSASGGEEALRIAREQRPDLIYLDCRMPEMDGVACCTILKGDRELRTIPVLMMVPEGKEKDRERCLAAGCDGIIAKPIDRREFLEAGRRFVPEVERRHQRIRCGSLAVFRRGNESFHGSIEDISFSGVYVGARCDVKMEDRIRLGFFLPGSDLIETDARVAWVNQGHRRIKSGLPEGFGVEFVGIAAKAADQVKRYIAAYVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QT2</accession>
    <name>Q39QT2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513896.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3179"/>
    <dbReference type="EnsemblBacteria" id="ABB33392">
        <property type="protein sequence ID" value="ABB33392"/>
        <property type="gene ID" value="Gmet_3179"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3179"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="FSCYKDD"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="120" mass="13395" checksum="80CA924BF3D8C143" modified="2005-11-22" version="1">MARLLVVDDESSIRLLYSQELADDGHEVATAATAAEAVEKIKESEFDLIVLDIKLKNESGLDLLQKVVKERHNLPVILCTAFSCFKDDFSAWLADGYVVKSSDLTELKEEVKRVLVKKGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QV5</accession>
    <name>HYPA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydrogenase maturation factor HypA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hypA</name>
        <name type="ordered locus">Gmet_3156</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypA/HybF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513872.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QV5"/>
    <dbReference type="SMR" id="Q39QV5"/>
    <dbReference type="STRING" id="269799.Gmet_3156"/>
    <dbReference type="EnsemblBacteria" id="ABB33369">
        <property type="protein sequence ID" value="ABB33369"/>
        <property type="gene ID" value="Gmet_3156"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3156"/>
    <dbReference type="eggNOG" id="COG0375">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126929_3_0_7"/>
    <dbReference type="OMA" id="EEQQAEC"/>
    <dbReference type="OrthoDB" id="1995603at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00213">
        <property type="entry name" value="HypA_HybF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020538">
        <property type="entry name" value="Hydgase_Ni_incorp_HypA/HybF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000688">
        <property type="entry name" value="HypA/HybF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34535">
        <property type="entry name" value="PTHR34535"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01155">
        <property type="entry name" value="HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004761">
        <property type="entry name" value="Hydrgn_mat_HypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00100">
        <property type="entry name" value="hypA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01249">
        <property type="entry name" value="HYPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000023828" description="Hydrogenase maturation factor HypA">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="2"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00213"/>
        </source>
    </evidence>
    <sequence length="110" mass="11957" checksum="E3F4056F0951A8B5" modified="2005-11-22" version="1">MHEMSITQSVVEICEKSAGGRRVLAVTLEIGDLSGVVPDAIEFCFEACTRDTLLEGARLVIERVPGRGECTSCGKEFPVRGYFDPCPACGAYGMRVVSGEELRVKELEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QW2</accession>
    <name>Q39QW2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3149"/>
    <dbReference type="EnsemblBacteria" id="ABB33362">
        <property type="protein sequence ID" value="ABB33362"/>
        <property type="gene ID" value="Gmet_3149"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3149"/>
    <dbReference type="eggNOG" id="COG1585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2034727_0_0_7"/>
    <dbReference type="OrthoDB" id="1951939at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="121" mass="13458" checksum="97B286089866C9C9" modified="2005-11-22" version="1">MARGGRQVVCEWWYWIVFGFALIGFELLFPSFTMVWFGLGALMVGGWSLFWGGFGLLVHVAIWVAVSAACSLCWRRYLRRRSSQGGGQDTSSPPFDGCSSVAGRAVHMVSRQGHLLRVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R22</accession>
    <name>Q39R22_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pccF</name>
        <name evidence="2" type="ordered locus">Gmet_3088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514542.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3088"/>
    <dbReference type="EnsemblBacteria" id="ABB33302">
        <property type="protein sequence ID" value="ABB33302"/>
        <property type="gene ID" value="Gmet_3088"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3088"/>
    <dbReference type="eggNOG" id="ENOG502Z9QE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033148_0_0_7"/>
    <dbReference type="OMA" id="PNNWAND"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024673">
        <property type="entry name" value="Octahem_Cyt_c"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11783">
        <property type="entry name" value="Cytochrome_cB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039014">
        <property type="entry name" value="OTR_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223279" evidence="1">
        <location>
            <begin position="22"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="454" mass="50219" checksum="C4EA8B48686DB0E2" modified="2005-11-22" version="1">MIKILFTGLVAGAVMASAAFAKDHPGREYMEKNGYKGPETCEVCHPGKAKEFLSTVHWTHASKVDNVENTDPTREYGMKNRIYTMCNGNDIVNNLKEIPKIPDAKGPKFSGCNTCHPGNHVSDVGSTGPEAEAAIDCLLCHSREYDYSKRKPFKDDQGRVVLGQDRSVKAALAIAKPTVKNCMTCHEAAGGGVLVKRGFAFTKENDVHAAKGMVCVDCHKAKNHKIPTGFDPNNWAHDGVRVACTDCHTETPHKDAEYNRHTARIACQTCHVTRTGGAFAKDFTKWEKLSSGYYEPTTLRKDANETVPVYAWYDKTVANRPDFIGPKGSRSDKASRIYPFKVFQGKGFFDRKTGKLLSMDFAPPMANGDTLAGVASAAKILGIKQYDPVPGWQTIMFGSNHLVTKKNALTCNNCHAPNGVLRFKELGYSDDEVKRLTSPELYLQKMAEKQREEW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-05-29" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R36</accession>
    <name>GCH4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTP cyclohydrolase FolE2</fullName>
            <ecNumber evidence="1">3.5.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">folE2</name>
        <name type="ordered locus">Gmet_3074</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts GTP to 7,8-dihydroneopterin triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = 7,8-dihydroneopterin 3'-triphosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17473"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58462"/>
            <dbReference type="EC" id="3.5.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase IV family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.16" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513633.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39R36"/>
    <dbReference type="SMR" id="Q39R36"/>
    <dbReference type="STRING" id="269799.Gmet_3074"/>
    <dbReference type="EnsemblBacteria" id="ABB33288">
        <property type="protein sequence ID" value="ABB33288"/>
        <property type="gene ID" value="Gmet_3074"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3074"/>
    <dbReference type="eggNOG" id="COG1469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062816_1_1_7"/>
    <dbReference type="OMA" id="PCSQGMS"/>
    <dbReference type="OrthoDB" id="757842at2"/>
    <dbReference type="UniPathway" id="UPA00848">
        <property type="reaction ID" value="UER00151"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003934">
        <property type="term" value="F:GTP cyclohydrolase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035998">
        <property type="term" value="P:7,8-dihydroneopterin 3'-triphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01527_B">
        <property type="entry name" value="GTP_cyclohydrol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022838">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003801">
        <property type="entry name" value="GTP_cyclohydrolase_FolE2/MptA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36445">
        <property type="entry name" value="PTHR36445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02649">
        <property type="entry name" value="GCHY-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000289491" description="GTP cyclohydrolase FolE2">
        <location>
            <begin position="1"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="site" description="May be catalytically important" evidence="1">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01527"/>
        </source>
    </evidence>
    <sequence length="261" mass="30182" checksum="080D014BD50FF10F" modified="2005-11-22" version="1">MTTMPDMQKTSDTRKIPINKVGVKDISYPIVVMDKNKKFQQTVARINMYVDLPHHFKGTHMSRFVEILNAYREDIALDKMEPILQKMKEKLGASSAHLEIEFPYFIEKRAPVSGARSLMEYTCTFCGSLGEEFDFVLGVQIPVTSLCPCSKELSRYGAHNQRSHITVRLRYTDFIWIEDLVAMIEECGSSPVWSLLKRVDEQYVTERAYENPKFVEDIVREVTQKLLAHDAITWFSVEAENFESIHKHSAYAAIERDKKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R50</accession>
    <name>Q39R50_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PLDc_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513619.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3059"/>
    <dbReference type="EnsemblBacteria" id="ABB33274">
        <property type="protein sequence ID" value="ABB33274"/>
        <property type="gene ID" value="Gmet_3059"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3059"/>
    <dbReference type="eggNOG" id="ENOG502Z9PB">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_453930_0_0_7"/>
    <dbReference type="OMA" id="WHPKIAL"/>
    <dbReference type="OrthoDB" id="146345at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLDc_2" evidence="1">
        <location>
            <begin position="295"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="591" mass="66050" checksum="01E4C59D0A2C0EEB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R65</accession>
    <name>Q39R65_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl:acetate coenzyme A transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ato-1</name>
        <name evidence="3" type="ordered locus">Gmet_3044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513604.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3044"/>
    <dbReference type="EnsemblBacteria" id="ABB33259">
        <property type="protein sequence ID" value="ABB33259"/>
        <property type="gene ID" value="Gmet_3044"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3044"/>
    <dbReference type="eggNOG" id="COG0427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019748_3_0_7"/>
    <dbReference type="OMA" id="DEALSWH"/>
    <dbReference type="OrthoDB" id="319106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="332"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="531" mass="58493" checksum="7AB197B494E9A431" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R89</accession>
    <name>PLSY_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate acyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acyl-PO4 G3P acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Acyl-phosphate--glycerol-3-phosphate acyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">G3P acyltransferase</fullName>
            <shortName evidence="1">GPAT</shortName>
            <ecNumber evidence="1">2.3.1.275</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lysophosphatidic acid synthase</fullName>
            <shortName evidence="1">LPA synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">plsY</name>
        <name type="ordered locus">Gmet_3020</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + sn-glycerol 3-phosphate = a 1-acyl-sn-glycero-3-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:34075"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="2.3.1.275"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; phospholipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Probably interacts with PlsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PlsY family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.275" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514334.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39R89"/>
    <dbReference type="SMR" id="Q39R89"/>
    <dbReference type="STRING" id="269799.Gmet_3020"/>
    <dbReference type="EnsemblBacteria" id="ABB33235">
        <property type="protein sequence ID" value="ABB33235"/>
        <property type="gene ID" value="Gmet_3020"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3020"/>
    <dbReference type="eggNOG" id="COG0344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081254_0_0_7"/>
    <dbReference type="OMA" id="WRHRGNL"/>
    <dbReference type="OrthoDB" id="1691856at2"/>
    <dbReference type="UniPathway" id="UPA00085"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043772">
        <property type="term" value="F:acyl-phosphate glycerol-3-phosphate acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01043">
        <property type="entry name" value="PlsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003811">
        <property type="entry name" value="G3P_acylTferase_PlsY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30309">
        <property type="entry name" value="PTHR30309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02660">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01207">
        <property type="entry name" value="G3P_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00023">
        <property type="entry name" value="TIGR00023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000250303" description="Glycerol-3-phosphate acyltransferase">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01043"/>
        </source>
    </evidence>
    <sequence length="194" mass="19949" checksum="34195A15626FFB20" modified="2005-11-22" version="1">MLIEILLLAGAYLLGSIPTGLLLAKAAGVDIRTTGSGNIGATNVYRTLGRSVGIATLVGDCLKGLIPVLAAKYLGMTDLWIALAGLAAFLGHVYTVFLGFKGGKGVATALGVFLGLAPLAVLIALGIFVAVVATSRYISLGSITAAAAMPPVVAFLSGRPPLVGVTVVIALLVIWKHRENIQRLRAGTENRFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RJ0</accession>
    <name>Q39RJ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512852.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33134">
        <property type="protein sequence ID" value="ABB33134"/>
        <property type="gene ID" value="Gmet_2916"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2916"/>
    <dbReference type="HOGENOM" id="CLU_908398_0_0_7"/>
    <dbReference type="OMA" id="YLTVEAH"/>
    <dbReference type="OrthoDB" id="1257583at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223196" evidence="1">
        <location>
            <begin position="30"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="306" mass="33551" checksum="8AD1A3B546E255D3" modified="2005-11-22" version="1">MSFRTNFMNGVKLSLILAGLAAVSSPAFALEQPADKGTGYLAVEARETAPESRELVQIFSPAINHREAKVTAGKDGTRLLTLTTDSILNGRAVRKFNQKLIEKGINVYGAAYYGDFSWDRTVIDAAITMTRPVAGVPDTIEISEGIARDPKTNLPLMPLTVSIYDLSIPLKEDFGKAWKRVEIIPAVEPAAPELKTGRYPGSRVWLVRQNDGERRHVIYAVKGDLHAVEQFFDAKLKEIHRTVIVAGDADSAPSPAEVFGVKTSAQVIVLSGYSYIDKKLVNSDVTLRHANDPNLFPYVEIEVAEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RM0</accession>
    <name>Q39RM0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33104.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512822.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2886"/>
    <dbReference type="DNASU" id="3740797"/>
    <dbReference type="EnsemblBacteria" id="ABB33104">
        <property type="protein sequence ID" value="ABB33104"/>
        <property type="gene ID" value="Gmet_2886"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2886"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068669_1_0_7"/>
    <dbReference type="OMA" id="IDMFLLM"/>
    <dbReference type="OrthoDB" id="1730305at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33104.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="266" mass="29626" checksum="42B60971E27ECCC3" modified="2012-10-31" version="2">MIDNCLYCGSATLLSIIHLANGKNAVTCGKCGLTRTIPVPSAEYSEVAEYFENYLLKEKLFRAFSRKLLDFVLSVVQNGRLLEVGCSVGFFLEEAKRAGFSVNGVELNEKAATLSKGKDFDVRNCMLREAGFPSHEFDVVVMSHVLEHIQDLREFLADIKVLLRPGGKVIVSQPTPDGIVPKMQKKKWYGWVPNEHVWHFTPKTLSLVFAENGFDVVKVERNSMYYSLWPSSLRGILVALVARTAAVLGLGDQFYLAATVSEKDSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RP1</accession>
    <name>RNH2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease HII</fullName>
            <shortName evidence="1">RNase HII</shortName>
            <ecNumber evidence="1">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnhB</name>
        <name type="ordered locus">Gmet_2865</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase HII family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514596.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RP1"/>
    <dbReference type="SMR" id="Q39RP1"/>
    <dbReference type="STRING" id="269799.Gmet_2865"/>
    <dbReference type="EnsemblBacteria" id="ABB33083">
        <property type="protein sequence ID" value="ABB33083"/>
        <property type="gene ID" value="Gmet_2865"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2865"/>
    <dbReference type="eggNOG" id="COG0164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036532_3_2_7"/>
    <dbReference type="OMA" id="YPTKLHL"/>
    <dbReference type="OrthoDB" id="1685277at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07182">
        <property type="entry name" value="RNase_HII_bacteria_HII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00052_B">
        <property type="entry name" value="RNase_HII_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022898">
        <property type="entry name" value="RNase_HII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="PTHR10954"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF18">
        <property type="entry name" value="PTHR10954:SF18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000235726" description="Ribonuclease HII">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-2" evidence="2">
        <location>
            <begin position="27"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <sequence length="213" mass="22575" checksum="F5EA4B69BD86632F" modified="2005-11-22" version="1">MRLPLFDDIGERSLWTFENLVSRNGFHAVAGVDEAGRGPLAGPVVAAAVILPQGAELPGVDDSKKLSAPKREHLFGLISGCALAVGVGVADHACIDRINILQATLRAMAEAVGQLAVPPDYLLIDGISTIPLNLPQKTIKKGDSSSISIASASIVAKVTRDRMMMEYDQQFPGYGFAEHKGYGCASHLAAIAELGPCPIHRKTFRGVKEHVAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RR5</accession>
    <name>RL9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplI</name>
        <name type="ordered locus">Gmet_2841</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514575.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RR5"/>
    <dbReference type="SMR" id="Q39RR5"/>
    <dbReference type="STRING" id="269799.Gmet_2841"/>
    <dbReference type="EnsemblBacteria" id="ABB33059">
        <property type="protein sequence ID" value="ABB33059"/>
        <property type="gene ID" value="Gmet_2841"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2841"/>
    <dbReference type="eggNOG" id="COG0359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078938_3_0_7"/>
    <dbReference type="OMA" id="MKIILTH"/>
    <dbReference type="OrthoDB" id="1959318at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.430.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00503">
        <property type="entry name" value="Ribosomal_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000244">
        <property type="entry name" value="Ribosomal_L9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009027">
        <property type="entry name" value="Ribosomal_L9/RNase_H1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020594">
        <property type="entry name" value="Ribosomal_L9_bac/chp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020069">
        <property type="entry name" value="Ribosomal_L9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036791">
        <property type="entry name" value="Ribosomal_L9_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020070">
        <property type="entry name" value="Ribosomal_L9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036935">
        <property type="entry name" value="Ribosomal_L9_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21368">
        <property type="entry name" value="PTHR21368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03948">
        <property type="entry name" value="Ribosomal_L9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01281">
        <property type="entry name" value="Ribosomal_L9_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55653">
        <property type="entry name" value="SSF55653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55658">
        <property type="entry name" value="SSF55658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00158">
        <property type="entry name" value="L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00651">
        <property type="entry name" value="RIBOSOMAL_L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000236526" description="50S ribosomal protein L9">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00503"/>
        </source>
    </evidence>
    <sequence length="148" mass="16184" checksum="603B15DD6FD580C5" modified="2005-11-22" version="1">MKVILKENLENLGHIGDIVKVAPGYARNYLLPRGYATEATEKNAKALEHAKRQLEYKRNKVLEQAKGLAAKIEGLTIAITHQAGEEGKLFGAVTNMELAEHLKAQGVEIDRKKIVLAEPIKHVGEYTASVKVHPEVAAALKVVITKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RT5</accession>
    <name>Q39RT5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hpnA</name>
        <name evidence="2" type="ordered locus">Gmet_2821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513983.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2821"/>
    <dbReference type="EnsemblBacteria" id="ABB33039">
        <property type="protein sequence ID" value="ABB33039"/>
        <property type="gene ID" value="Gmet_2821"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2821"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_0_7"/>
    <dbReference type="OMA" id="GAYKRSK"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017829">
        <property type="entry name" value="Hopanoid-assoc_sugar_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03466">
        <property type="entry name" value="HpnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="328" mass="35477" checksum="7BD96570A7BD75D6" modified="2005-11-22" version="1">MKVFVTGATGFIGASIARELLKDGCHVRVLARPGSDRRNLDGLDVEVCEGDLCSPESLDRGVKGCEVLYHAAADYRLWTRNPAAMYAANVEGTRHVLDAALRHGVSRVVYTSSVGTLGNPGDGTPGTEATPVTFADMVGDYKKSKFLAEREAETFLARGLPLVIVNPSTPVGPHDVKPTPTGKIIVDFLNRAMPAYLDTGLNIIDVEDCAQGHILAAQHGRIGEKYILGHENLTLRQIFSLLETVTGLAAPKVRLPYLPILAAAYANEALSRITGREPLIPLAGVQMARKFMYFDSSKAVKELGLPQRPAVEALGRAVEWFRANGYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RW4</accession>
    <name>Q39RW4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA polymerase sigma factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sigma-70 factor family. ECF subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2792"/>
    <dbReference type="EnsemblBacteria" id="ABB33010">
        <property type="protein sequence ID" value="ABB33010"/>
        <property type="gene ID" value="Gmet_2792"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2792"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_3_4_7"/>
    <dbReference type="OMA" id="WLFQIAN"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050896">
        <property type="term" value="P:response to stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014304">
        <property type="entry name" value="RNA_pol_sigma-Z"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02959">
        <property type="entry name" value="SigZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r2" evidence="2">
        <location>
            <begin position="33"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma70_r4_2" evidence="3">
        <location>
            <begin position="123"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="206" mass="23237" checksum="41FDE3558D4E7549" modified="2005-11-22" version="1">MDTGRAEKLPERVNCVTRYAREFTMKTSEQIWQEYHLRLRAFIKSRIADDAVADDTLQNVFLKMHAGLPSLKDGTKLQSWLYQIARNAIIDLYRSQKASTGIPVSLAHPESNPGEKAVQELSDCLQPMIQRLPEIYREAIILSELEGLTQREVAEVLGTSLSGAKSRVQRGRALLKGMIADCCRLELDHNGRLCDYERKGKACDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RX5</accession>
    <name>Q39RX5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511680.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2781"/>
    <dbReference type="EnsemblBacteria" id="ABB32999">
        <property type="protein sequence ID" value="ABB32999"/>
        <property type="gene ID" value="Gmet_2781"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2781"/>
    <dbReference type="eggNOG" id="COG4768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1945695_0_0_7"/>
    <dbReference type="OMA" id="HNIRMIN"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009293">
        <property type="entry name" value="UPF0478"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06103">
        <property type="entry name" value="DUF948"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="129" mass="13814" checksum="7927A1AE20FA4EB8" modified="2005-11-22" version="1">MTVTAIAVVVIALALVVLVAFIIPTLIEIRKAAADLRGFVSRTGGELKPVLLELERTLTELRTVTEGIAEKREDVQTFMEAVGDTGRNLRTINTVVSSVAHAAATSSVWITGARTAGKFLAQRLITKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S42</accession>
    <name>Q39S42_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511746.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2714"/>
    <dbReference type="DNASU" id="3740021"/>
    <dbReference type="EnsemblBacteria" id="ABB32932">
        <property type="protein sequence ID" value="ABB32932"/>
        <property type="gene ID" value="Gmet_2714"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2714"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_1_7"/>
    <dbReference type="OMA" id="SINVSIY"/>
    <dbReference type="OrthoDB" id="1094814at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="121"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="318" mass="35730" checksum="41DF5D6BAAAADD8E" modified="2005-11-22" version="1">MKSRFYRPLSLASVSPSYFPEIALYVRNSGNYILYKNHDRQFTEEDRHRLERTNTSFLYVRSGDMDAVTEYLEQNLDTLLARDDIDSNAKGTILYQTAANYVTDVFDEPGKTADIIRCRSLIRHLMKYVAGHEDALKALQAITSQNYYIFTHSVQVAALMMLVHDRLFRLNQDEMIDVGIGSLLHDVGMVFLSGQLLDKPDALAAIEYHKAKQHAQKGYEHLQSAGTLSEVSLTIVRHHHEKYDGSGYPAGLKGDDIPRSAQLAALCDTYCAMTTDRPKHTALPGAEALRIMEDEVGGAFSPDLFYRFADVVKGKGKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S52</accession>
    <name>PSTB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphate import ATP-binding protein PstB</fullName>
            <ecNumber evidence="1">7.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ABC phosphate transporter</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphate-transporting ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pstB</name>
        <name type="ordered locus">Gmet_2704</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + phosphate(out) = ADP + H(+) + 2 phosphate(in)</text>
            <dbReference type="Rhea" id="RHEA:24440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.3.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family.</text>
    </comment>
    <dbReference type="EC" id="7.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511757.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39S52"/>
    <dbReference type="SMR" id="Q39S52"/>
    <dbReference type="STRING" id="269799.Gmet_2704"/>
    <dbReference type="EnsemblBacteria" id="ABB32922">
        <property type="protein sequence ID" value="ABB32922"/>
        <property type="gene ID" value="Gmet_2704"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2704"/>
    <dbReference type="eggNOG" id="COG1117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="TIDICRV"/>
    <dbReference type="OrthoDB" id="1416748at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015415">
        <property type="term" value="F:ATPase-coupled phosphate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03260">
        <property type="entry name" value="ABC_PstB_phosphate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015850">
        <property type="entry name" value="ABC_transpr_PstB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005670">
        <property type="entry name" value="Phosp_transpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423">
        <property type="entry name" value="PTHR43423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43423:SF3">
        <property type="entry name" value="PTHR43423:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00972">
        <property type="entry name" value="3a0107s01c2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51238">
        <property type="entry name" value="PSTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0592">Phosphate transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000272456" description="Phosphate import ATP-binding protein PstB">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="5"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01702"/>
        </source>
    </evidence>
    <sequence length="252" mass="28395" checksum="2518D27FCA5791B2" modified="2005-11-22" version="1">MNTKVKIDKLNVHFGQTHAVKDVSIDVPENTVTAIIGPSGCGKSTMLRSLNRMHDLFPNARVTGKVLLDGNDIYDRKVDPVSIRRRVGMVFQKPNPFPAMSIYDNVVAGYKLNGRVKKSDADEIVETSLRRVALWDEVKDRLKSNSMELSGGQQQRLCIARTIAVQPEVILMDEPASALDPISTLKIEELIEELTEKYTIIIVTHNMQQAARVSDYTAFFYMGDLVEWGETKKLFTTPEKKQTEDYITGRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S62</accession>
    <name>Q39S62_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">phoR</name>
        <name evidence="10" type="ordered locus">Gmet_2694</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511767.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2694"/>
    <dbReference type="EnsemblBacteria" id="ABB32912">
        <property type="protein sequence ID" value="ABB32912"/>
        <property type="gene ID" value="Gmet_2694"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2694"/>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_2_7"/>
    <dbReference type="OMA" id="LTFWAVN"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031967">
        <property type="entry name" value="PhoR_single_Cache-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16736">
        <property type="entry name" value="sCache_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="192"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="371"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="589" mass="64239" checksum="B6F441B504A4B832" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S76</accession>
    <name>Q39S76_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511780.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2680"/>
    <dbReference type="EnsemblBacteria" id="ABB32898">
        <property type="protein sequence ID" value="ABB32898"/>
        <property type="gene ID" value="Gmet_2680"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2680"/>
    <dbReference type="eggNOG" id="COG3605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1150563_0_0_7"/>
    <dbReference type="OMA" id="CGRVMKS"/>
    <dbReference type="OrthoDB" id="1258482at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="93"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="245" mass="27546" checksum="BE90673B24AD7FA5" modified="2005-11-22" version="1">MHMVRCRKCGRVMKSERIDPYRVKLSCVCGFSDFRAVPDKAKTVNPFYQKASLTPFVESEKGKMVLTMQRANREHLEIISLEEISMLVSSDFNLPEVLQHVTKKVAGQLKVSVCSIYLREGDDLVLAATHGFDPAFIGKIRLRIGEGITGTVAKEGSHISLTHASRDSRYKHFSELQEEKYNSMLSFPISDKKEVYGVINLNTTSIKSFQEDEIYFVSIIANLILTAIKLRQQVATGKKALQPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S96</accession>
    <name>Q39S96_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511801.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2660"/>
    <dbReference type="EnsemblBacteria" id="ABB32878">
        <property type="protein sequence ID" value="ABB32878"/>
        <property type="gene ID" value="Gmet_2660"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2660"/>
    <dbReference type="HOGENOM" id="CLU_1033498_0_0_7"/>
    <dbReference type="OMA" id="AEGNLMY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223047" evidence="2">
        <location>
            <begin position="36"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="269" mass="29638" checksum="EFD7EFE30BCC225D" modified="2005-11-22" version="1">MKASTVVTKRCNPRALLPCLVLLAALAVWDGPAQAGTSLPSSALPLTHSVPHELIPGIPDPDGFVTVEVGDYFSCDIPPEWSRVDNYGSGLGLSNEEKKTYGFHLKAPEPGEPSVAISIFYYAEGNLMYKSVDHYLRVFAQPALGVSLDGSSYGDVTAVKVAGRDGMVFERVKKEYAPRESGTGGPVKPGVYIRPGLNATRIPIRERFVVLPAKQGFFALRYTAPEEKFREFLPVFEKVTQRFFPGGRYTYESRDTERGPSHDYGHEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SD8</accession>
    <name>Q39SD8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Barnase inhibitor barstar</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2617</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the barstar family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511844.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2617"/>
    <dbReference type="EnsemblBacteria" id="ABB32836">
        <property type="protein sequence ID" value="ABB32836"/>
        <property type="gene ID" value="Gmet_2617"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2617"/>
    <dbReference type="eggNOG" id="COG2732">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121832_2_2_7"/>
    <dbReference type="OMA" id="CELTHIH"/>
    <dbReference type="OrthoDB" id="2047621at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000468">
        <property type="entry name" value="Barstar"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035905">
        <property type="entry name" value="Barstar-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01337">
        <property type="entry name" value="Barstar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52038">
        <property type="entry name" value="SSF52038"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Barstar" evidence="2">
        <location>
            <begin position="10"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="95" mass="11160" checksum="9FE9DBE4A07E615F" modified="2005-11-22" version="1">MPVKRVKHCTISGRAVHSLDELYDEIARQLPLPDYFGRNLDALWDVLSTDIEGPVELIWEDSEHSKRSMGKDYERVVALLKDLTEEREDFRIVFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SK4</accession>
    <name>Q39SK4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2551</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513483.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2551"/>
    <dbReference type="EnsemblBacteria" id="ABB32770">
        <property type="protein sequence ID" value="ABB32770"/>
        <property type="gene ID" value="Gmet_2551"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2551"/>
    <dbReference type="HOGENOM" id="CLU_1832303_0_0_7"/>
    <dbReference type="OMA" id="AAFDYAC"/>
    <dbReference type="OrthoDB" id="1902509at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="140" mass="15790" checksum="9741476F177EA084" modified="2005-11-22" version="1">MFGLFRKKVGEPIEFGSTDAAFDYACRNLENRILLEAVIPALVEERRGMSPEGEQLFFIRLANREGGKVIEACTLKESLRHPAVGDLVGYRVVKVEPELPEPFDLLGFIACRLQPVYVPGRGWRIAESFVPDNIKPTLRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SR8</accession>
    <name>Q39SR8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lytic transglycosylase lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2481</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32706.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366060.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2481"/>
    <dbReference type="EnsemblBacteria" id="ABB32706">
        <property type="protein sequence ID" value="ABB32706"/>
        <property type="gene ID" value="Gmet_2481"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2481"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1281666_0_0_7"/>
    <dbReference type="OMA" id="GVWQLMP"/>
    <dbReference type="OrthoDB" id="1473800at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223239" evidence="1">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="100"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32706.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="215" mass="24033" checksum="BDF1BB002873A6FE" modified="2012-10-31" version="2">MKKMILLSAVMMLTGVSCNQTALRRDPVTVVLSESGVDLEVRRLMDQGIELDERQRQARAIATVFARRTTPDRAYRLASLCYLKTLGTDFMPLDLAELALAETGSIGFDPKAVSSKGALGVWQLMPYRAESHGFNPHEMANDEKCAEAAVRELATKLDMARGNLVRAKKLYCGVGPEADAYEIKRRRYQREILRELGTPLHVRAVDLRFSFAKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SR9</accession>
    <name>Q39SR9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WHy domain lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512419.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2480"/>
    <dbReference type="EnsemblBacteria" id="ABB32705">
        <property type="protein sequence ID" value="ABB32705"/>
        <property type="gene ID" value="Gmet_2480"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2480"/>
    <dbReference type="eggNOG" id="COG5608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1592201_0_0_7"/>
    <dbReference type="OMA" id="GAGMELY"/>
    <dbReference type="OrthoDB" id="1795852at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009269">
        <property type="term" value="P:response to desiccation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004864">
        <property type="entry name" value="LEA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013990">
        <property type="entry name" value="WHy-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03168">
        <property type="entry name" value="LEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00769">
        <property type="entry name" value="WHy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223225" evidence="1">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="WHy" evidence="2">
        <location>
            <begin position="26"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="167" mass="18650" checksum="FCB9F7EF508AF90D" modified="2005-11-22" version="1">MKKLLILVVCMIFCAGCSLFLDKPEVKVRDLNVVGIGVEGVDLEFLLTVTNPNSFPLVLNGYTYDLNVMALPLTKGGKRERIEFPADKATDVRLPFKVAYGDLWEILKRQPDQNKIPYRLNAGLEVETPFGTTTVPVSKESVFAVPERYRTSGILKGVTDLLKGFRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T20</accession>
    <name>Q39T20_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (cytidine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.207</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmL</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">trmL</name>
        <name evidence="6" type="ordered locus">Gmet_2379</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S-adenosyl-L-methionine to the 2'-OH of the wobble nucleotide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5-carboxymethylaminomethyluridine(34) in tRNA(Leu) + S-adenosyl-L-methionine = 5-carboxymethylaminomethyl-2'-O-methyluridine(34) in tRNA(Leu) + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43088"/>
            <dbReference type="Rhea" id="RHEA-COMP:10333"/>
            <dbReference type="Rhea" id="RHEA-COMP:10334"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74508"/>
            <dbReference type="ChEBI" id="CHEBI:74511"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cytidine(34) in tRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(34) in tRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:43084"/>
            <dbReference type="Rhea" id="RHEA-COMP:10331"/>
            <dbReference type="Rhea" id="RHEA-COMP:10332"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.207"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.207" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514762.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2379"/>
    <dbReference type="EnsemblBacteria" id="ABB32604">
        <property type="protein sequence ID" value="ABB32604"/>
        <property type="gene ID" value="Gmet_2379"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2379"/>
    <dbReference type="eggNOG" id="COG0219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110125_2_1_7"/>
    <dbReference type="OMA" id="AGLDYWH"/>
    <dbReference type="OrthoDB" id="1578095at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008175">
        <property type="term" value="F:tRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18094">
        <property type="entry name" value="SpoU-like_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01885">
        <property type="entry name" value="tRNA_methyltr_TrmL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016914">
        <property type="entry name" value="tRNA_cyt/urid_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42971">
        <property type="entry name" value="PTHR42971"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029256">
        <property type="entry name" value="SpoU_TrmH_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SpoU_methylase" evidence="5">
        <location>
            <begin position="7"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR029256-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="158" mass="17627" checksum="6DD03C2220A19EB2" modified="2005-11-22" version="1">MPEKPPFHIVLIEPEIPPNTGNIARLCGATGTVLHLVGKLGFSTDDRYLKRAGLDYWSEVEIHYWDDLAALQHAYPEGRFIYTSKKAAKTHIEAAFKEGDFIVFGKETVGLPEELIEANRENTVRIPIFGKVRSLNLSTSAGIVLYEALRQTGRLEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T46</accession>
    <name>Q39T46_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase</fullName>
            <shortName evidence="6">UDP-N-acetylglucosamine acyltransferase</shortName>
            <ecNumber evidence="6">2.3.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">lpxA-1</name>
        <name evidence="6" type="synonym">lpxA</name>
        <name evidence="8" type="ordered locus">Gmet_2353</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a (3R)-hydroxyacyl-[ACP] + UDP-N-acetyl-alpha-D-glucosamine = a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:67812"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="2.3.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 1/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the transferase hexapeptide repeat family. LpxA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.129" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513267.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2353"/>
    <dbReference type="EnsemblBacteria" id="ABB32578">
        <property type="protein sequence ID" value="ABB32578"/>
        <property type="gene ID" value="Gmet_2353"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2353"/>
    <dbReference type="eggNOG" id="COG1043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061249_0_0_7"/>
    <dbReference type="OMA" id="ECVTINR"/>
    <dbReference type="OrthoDB" id="971098at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00477"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00387">
        <property type="entry name" value="LpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="7">
        <location>
            <begin position="174"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="256" mass="27604" checksum="4C096CE78710D4BC" modified="2005-11-22" version="1">MIHPTAIVHPEAQVAEGVEIGPYAIIGEHVRIGRGSRIGAHSVIDGWTDIGEECQIFHMASVGGIPQDLKYRGEETWLRIGKRNIIREFTTLQPGTVTGIGETVIGEGNLFMAYCHVAHDCVVGNRVIMANGSTLAGHVVVEDHAILGGLSAVHQFTRVGESAMLSGGAMVGQDVLPYTIASGNRATSAGLNTVGLKRRGFSPDTISAVKKAYRLMLRSGLRLDEAIARIREEVPMSPEIVHFIEFAQKSERGICR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T66</accession>
    <name>Q39T66_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyltransferase, left-handed parallel beta-helix (Hexapeptide repeat) family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2333</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513287.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2333"/>
    <dbReference type="EnsemblBacteria" id="ABB32558">
        <property type="protein sequence ID" value="ABB32558"/>
        <property type="gene ID" value="Gmet_2333"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2333"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081811_2_0_7"/>
    <dbReference type="OMA" id="MPVNAIH"/>
    <dbReference type="OrthoDB" id="1878940at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03360">
        <property type="entry name" value="LbH_AT_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041561">
        <property type="entry name" value="PglD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020019">
        <property type="entry name" value="Sia_OAcTrfase_NeuD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17836">
        <property type="entry name" value="PglD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03570">
        <property type="entry name" value="NeuD_NnaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PglD_N" evidence="3">
        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="220" mass="22754" checksum="BA4E543A5A14C4FD" modified="2005-11-22" version="1">MWPGGNNVKKLVVWGASGHAMVVADIVRLRGEYDIVGFLDDVTEGRNGEEFFGLPVFSGRDSLAMLCGQGVRHAIVAFGNCPARLKVAEYLRAQGLELVTAVHPSAVVARDVVIGEGTVVAAGAVINPGVHVGANVIINTSASVDHECTIEDGAHICPGVRLAGRVAVGEGAWIGIGSSIIDRVRIGAGSFIGAGSVVVGDIPDNALAYGVPAKIRKRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T81</accession>
    <name>Q39T81_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Thymidylate kinase</fullName>
            <ecNumber evidence="3 6">2.7.4.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">dTMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tmk</name>
        <name evidence="8" type="synonym">tmk-1</name>
        <name evidence="8" type="ordered locus">Gmet_2318</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>ATP + dTMP = ADP + dTDP</text>
            <dbReference type="Rhea" id="RHEA:13517"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58369"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the thymidylate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3 6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513302.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2318"/>
    <dbReference type="EnsemblBacteria" id="ABB32543">
        <property type="protein sequence ID" value="ABB32543"/>
        <property type="gene ID" value="Gmet_2318"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2318"/>
    <dbReference type="eggNOG" id="COG0125">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049131_0_2_7"/>
    <dbReference type="OMA" id="VMTREPG"/>
    <dbReference type="OrthoDB" id="1585072at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:thymidylate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00165">
        <property type="entry name" value="Thymidylate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018094">
        <property type="entry name" value="Thymidylate_kinase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00041">
        <property type="entry name" value="DTMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate_kin" evidence="7">
        <location>
            <begin position="7"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="217" mass="23280" checksum="3886DA0E6A9D1BD8" modified="2005-11-22" version="1">MGFFITFEGIEGCGKSTQVRLVAERLSRAGHGVVVTREPGGCPIADAIRAILLDARNSAMVPMAELLLYAAARAQHVAEVIEPALAAGKIVLCDRFTDSTMAYQGFGRKLDRELIAQLNSLAAGSIRPDLTLLLDCSVETGLARAMARINTSSAAREERFEQESILFHERIRDGFLSLAAAEPGRFVVLDGSGGIEETEALVTEAILARLPASPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TC4</accession>
    <name>Q39TC4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32500">
        <property type="protein sequence ID" value="ABB32500"/>
        <property type="gene ID" value="Gmet_2274"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2274"/>
    <dbReference type="eggNOG" id="ENOG5032I1Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771078_0_0_7"/>
    <dbReference type="OMA" id="DEYELRF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="359" mass="40426" checksum="F2304B521D9A9160" modified="2005-11-22" version="1">MRKFRQGQNILEIGEIMSDLFDSSGPNFNVVLPCTPETFKEFVSGLLGAPQTITREFEGSYEVHQEDIVNLYHLIDQRVSQQNPSTCVQFTVKTIYDDGSTVKQNSLSDFCAYNEIRPVISVGLVITWTYLVKFRDKAAPEKQIITVSFGQTDKIIASRGIRIKFLSMDAIDFRIDHTGRTWGADIEALLTNHINNITKKEPNIKKIVRKNSELIGLLLGGSLFITTAIAGVMANSDFLDKQQKIAADILRNKSADIGNMLSKLEYLINQNASGQWHIFYNKLAIMLFVALFASIIIGIVIAEAADNREPSFILLTKKSQENKNIVLKKMKKKWVVFIISSMLSIALGILSNIIYNKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TD8</accession>
    <name>Q39TD8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Succinate--CoA ligase [ADP-forming] subunit alpha</fullName>
            <ecNumber evidence="2">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="2">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">sucD-3</name>
        <name evidence="2" type="synonym">sucD</name>
        <name evidence="7" type="ordered locus">Gmet_2260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 5">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 5">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 5">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366016.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2260"/>
    <dbReference type="EnsemblBacteria" id="ABB32486">
        <property type="protein sequence ID" value="ABB32486"/>
        <property type="gene ID" value="Gmet_2260"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2260"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052104_0_0_7"/>
    <dbReference type="OMA" id="VIICITE"/>
    <dbReference type="OrthoDB" id="1081709at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001553">
        <property type="entry name" value="SucCS_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA_binding" evidence="6">
        <location>
            <begin position="4"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Coenzyme A binding" evidence="2">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2 3">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001553-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="291" mass="30250" checksum="1517C451077D7228" modified="2005-11-22" version="1">MSILINKDTKVITQGLGATGLFHANGAREYGTQMVGGVTPGKGGTVIDGFPVYDTVREAVAKTGATASVIYVPPPFAADSIMEAVDAGLDLVICITEGIPVLDMVKVKQYMQGKKTRLVGPNCPGVITPGQCKIGIMPGYIHKPGKVGVVSRSGTLTYEAVWQLTNVGLGQSTCVGIGGDPVNGTNHVDVLRMFEEDPDTEAVIMIGEIGGNSEEEGARFVKEHMTKPVAAYIAGVTAPPGKRMGHAGAIISGGKGTATEKVAILEECGISVAQSPADMAKALLKIYKPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TL0</accession>
    <name>Q39TL0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365943.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2186"/>
    <dbReference type="EnsemblBacteria" id="ABB32414">
        <property type="protein sequence ID" value="ABB32414"/>
        <property type="gene ID" value="Gmet_2186"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2186"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4753">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="HERISSC"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="12"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="171"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="130"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="381" mass="42807" checksum="EB914925E9DB930B" modified="2005-11-22" version="1">MTASDAEERGIALLYVEDEPGTREMFSLIISRRYPELRIIVAEDGQSGFVAFRQNLPQIVITDINMPVTDGLKMAAEIKALSPQTEIIALTAYANTQQLLQAIEIGISHYILKPIDIQQIFAVLDKVLSIIRAQQEISRQNELIRSLNADLARKAADLEMANSELEAFNYTVAHDLRSPMVSISGFSQVLLEMHAAVLNDEGKKYLGIIHREVLRMSNLIGVLLKFSLYSRKRVEKSWSDLSGMANEIKTNLLLQQPDCRAVFSIAEGVKGFCDPELLRIVLENLFENALKYSMKKEDAHIEFGMVNQEDDLIYFVRDNGIGFDQQDADKLFLPFQRLECDREIAGFGIGLATASRIIQRHGGKIWAEGEKGIGATFYFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TU3</accession>
    <name>Q39TU3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phenylphosphate carboxylase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513102.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2102"/>
    <dbReference type="EnsemblBacteria" id="ABB32331">
        <property type="protein sequence ID" value="ABB32331"/>
        <property type="gene ID" value="Gmet_2102"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2102"/>
    <dbReference type="eggNOG" id="COG0043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023348_5_0_7"/>
    <dbReference type="OMA" id="FESHCLW"/>
    <dbReference type="OrthoDB" id="1012819at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014096">
        <property type="entry name" value="Phenyl_P_COase_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="PTHR30108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02724">
        <property type="entry name" value="phenyl_P_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00148">
        <property type="entry name" value="TIGR00148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="514" mass="57895" checksum="4C8B8E7C83C74E02" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TZ0</accession>
    <name>Q39TZ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54-dependent sensor transcriptional regulator, PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2055</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514048.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2055"/>
    <dbReference type="EnsemblBacteria" id="ABB32284">
        <property type="protein sequence ID" value="ABB32284"/>
        <property type="gene ID" value="Gmet_2055"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2055"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_8_1_7"/>
    <dbReference type="OMA" id="LEAKYTF"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="19"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="139"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="269"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="600" mass="66271" checksum="D27F092D6E97DC0E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U44</accession>
    <name>Q39U44_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, YqgM-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2001"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="DNASU" id="3739873"/>
    <dbReference type="EnsemblBacteria" id="ABB32230">
        <property type="protein sequence ID" value="ABB32230"/>
        <property type="gene ID" value="Gmet_2001"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2001"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_7"/>
    <dbReference type="OMA" id="YASCPAI"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="195"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="380" mass="40483" checksum="6CD2AAF4D5EE13DE" modified="2005-11-22" version="1">MTVEPLHILHLISTSGLFGAERVLLELASQSRSLGMHVTVAALKNSRNPNTELAEAARGAGLPTLVVPCGGRFDAGVVGILTEEIRKSGTQIIHSHNYKSNYYARQAAELSGARWIVTNHGRRAGFKLFLYALLDAMLVRKADRVVAVSPKIADRLAVLGIGRDGLSVIDNGVDFSRFESLPTKADAGNVLGVAGSSYVIGTVGALTEEKGHRHLLQAVKSVRKSIPNVVCVVVGDGPERRRLEQLAREEGIEQTAIFTGKRDDVPSILPRFDLFVLPSLSEGLPMALLEAQAAKVPAIATNVGAIATVINNGVTGVVVSPGDVPALAEAIIRSHDEADKARCMALKGYERVKVHYSADTMAQRYIEIYRGMIGAGGAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U61</accession>
    <name>Q39U61_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPOR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512967.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1984"/>
    <dbReference type="EnsemblBacteria" id="ABB32213">
        <property type="protein sequence ID" value="ABB32213"/>
        <property type="gene ID" value="Gmet_1984"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1984"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_699727_0_0_7"/>
    <dbReference type="OrthoDB" id="1776173at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="291"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="370" mass="39477" checksum="886B6218A5377B14" modified="2005-11-22" version="1">MNIEFDQEPGDTSSKGGGSNTRLLLLVLLLLVAVFGYLFYFTDLIKPRQEVQAPAPVQPSQVKQPIPPRPAEQPAGSAPVEPAKPAAVTPPATGQPEPAKVAQEQKTPEKAKAEPPAPVKSAAPPAKKEQSKPAEPAKAPVAKKEQPKPAEQAKAPVEAKQKALQAKTDDRQKTAASSKEAKQAAPVKPKTAAAKKVAKKAATGVKASSVKASAAAAAGEYTLRIGEYVVPSAMEKDNAKVREAGLTPVVKEGNKKKEPMIRLLFGEFADQETARKELQKLRDATVEGFVLNEGGKYRVYAGSYFVKARAMQEQQRLEALGYKLTLRKANVSVPVLLLTAGKYGSREEALRDVSRLKKKGLSAAVIANVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UA9</accession>
    <name>EX7S_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exodeoxyribonuclease 7 small subunit</fullName>
            <ecNumber evidence="1">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exodeoxyribonuclease VII small subunit</fullName>
            <shortName evidence="1">Exonuclease VII small subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xseB</name>
        <name type="ordered locus">Gmet_1936</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XseB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511907.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UA9"/>
    <dbReference type="SMR" id="Q39UA9"/>
    <dbReference type="STRING" id="269799.Gmet_1936"/>
    <dbReference type="EnsemblBacteria" id="ABB32165">
        <property type="protein sequence ID" value="ABB32165"/>
        <property type="gene ID" value="Gmet_1936"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1936"/>
    <dbReference type="eggNOG" id="COG1722">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145918_3_3_7"/>
    <dbReference type="OMA" id="PLNDYKG"/>
    <dbReference type="OrthoDB" id="2057189at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00337">
        <property type="entry name" value="Exonuc_7_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003761">
        <property type="entry name" value="Exonuc_VII_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037004">
        <property type="entry name" value="Exonuc_VII_ssu_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34137">
        <property type="entry name" value="PTHR34137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02609">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006488">
        <property type="entry name" value="Exonuc_VII_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116842">
        <property type="entry name" value="SSF116842"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01280">
        <property type="entry name" value="xseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000303710" description="Exodeoxyribonuclease 7 small subunit">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00337"/>
        </source>
    </evidence>
    <sequence length="76" mass="8624" checksum="D18E016D1782DD57" modified="2005-11-22" version="1">MAVEKFETALKKLEDVVNRLESGELSLDDSLKAFEEGVKMAAFCTKKLDEAEKKVEILLKKKDGSFAKEPFRLEDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UH2</accession>
    <name>CLPP_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease proteolytic subunit</fullName>
            <ecNumber evidence="1">3.4.21.92</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Endopeptidase Clp</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpP</name>
        <name type="ordered locus">Gmet_1873</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).</text>
            <dbReference type="EC" id="3.4.21.92"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S14 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.92" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511972.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UH2"/>
    <dbReference type="SMR" id="Q39UH2"/>
    <dbReference type="STRING" id="269799.Gmet_1873"/>
    <dbReference type="MEROPS" id="S14.001"/>
    <dbReference type="EnsemblBacteria" id="ABB32102">
        <property type="protein sequence ID" value="ABB32102"/>
        <property type="gene ID" value="Gmet_1873"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1873"/>
    <dbReference type="eggNOG" id="COG0740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058707_3_2_7"/>
    <dbReference type="OMA" id="RDYWMKA"/>
    <dbReference type="OrthoDB" id="1728970at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07017">
        <property type="entry name" value="S14_ClpP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00444">
        <property type="entry name" value="ClpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001907">
        <property type="entry name" value="ClpP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023562">
        <property type="entry name" value="ClpP/TepA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018215">
        <property type="entry name" value="ClpP_Ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10381">
        <property type="entry name" value="PTHR10381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00574">
        <property type="entry name" value="CLP_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00127">
        <property type="entry name" value="CLPPROTEASEP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00493">
        <property type="entry name" value="clpP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00381">
        <property type="entry name" value="CLP_PROTEASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0645">Protease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0720">Serine protease</keyword>
    <feature type="chain" id="PRO_0000226448" description="ATP-dependent Clp protease proteolytic subunit">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00444"/>
        </source>
    </evidence>
    <sequence length="199" mass="21756" checksum="8C8FFEF0A7A4F748" modified="2005-11-22" version="1">MLVPIVVEQTGRGERSYDIYSRLLKDRIIFLGGPIDDHVANLVIAQLLFLEAEDPDKDIHLYINSPGGVVTAGMAIYDTMQYIKAPVSTICVGQAASMGALLLSGGEKGKRFSLTHSRIMIHQPLGGFQGQATDIHIHAQEILKMKKRLNEIIAENSGQALEKVEADTERDYFMSGEEAKSYGIIDAIIARKPTSGGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UN4</accession>
    <name>Q39UN4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Menaquinol oxidoreductase complex ACIII, iron-sulfur cluster-binding subunit ActB2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">actB2</name>
        <name evidence="2" type="ordered locus">Gmet_1811</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512035.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1811"/>
    <dbReference type="EnsemblBacteria" id="ABB32040">
        <property type="protein sequence ID" value="ABB32040"/>
        <property type="gene ID" value="Gmet_1811"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1811"/>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_1_0_7"/>
    <dbReference type="OMA" id="MAACPYH"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="237" mass="27005" checksum="66D0FDA33FC7E9A8" modified="2005-11-22" version="1">METMTSQYRWGMVVDLDRCTGCGACVVACQAENNVAICGKKEISEGRNMHWLRIERFWVGQYPDVRARFLPVLCQHCHDAPCEPVCPVYASYHNPDGLNGQVYNRCVGTRYCGNNCPYAVRVFNFYNHEWPNPLDNQLSPDMTVRTRGVMEKCTFCIQRIRRAKEDAKSENRTIRDGEIQPACAQTCPTDALVFGNMADPRSRVAILSRSPRRFRLLEHLGTHPSICYLKGGGREHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UN8</accession>
    <name>Q39UN8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1807</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512039.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1807"/>
    <dbReference type="EnsemblBacteria" id="ABB32036">
        <property type="protein sequence ID" value="ABB32036"/>
        <property type="gene ID" value="Gmet_1807"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1807"/>
    <dbReference type="eggNOG" id="COG1964">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023791_0_0_7"/>
    <dbReference type="OMA" id="RCDIHYA"/>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034474">
        <property type="entry name" value="Methyltransferase_Class_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43306">
        <property type="entry name" value="PTHR43306"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01100">
        <property type="entry name" value="methyltransferase_(Class_D)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="88"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="465" mass="50431" checksum="F646217DC4D95132" modified="2005-11-22" version="1">METVNLGETESICPVCLKRIAATRQVLGDEVFQVKECDEHGSFRTLIWRGKPSLAEWRRPKPPVHPELCYGTVEQGCPFDCGLCSAHAQMPCSVLLEVTDRCNLQCAVCFADSGRKDSVDTSLDRITWLLERAMAAAGPCNLQLSGGEPTLRDDLPEIVAAARRIGFSFIQLNTNGLRLAADGNYAARLRSAGLSAVFLQFDGVDDGIYRTLRGRPLLEQKLRAVRHAGEAGLGVILVPTIVSGVNSHAVGAIVRQALQLAPIVRGIHFQPVSYFGRFPEQGCGNRFTLPELMGCLEEQTDGLLRLADFSPPGGEHAHCSFHATYLYSADGGLRSLGAMGGDSCCTTDCGSGGIRRTVDTVSRRWKLPSAAPCCGNPRESEQTDCCESGRSNPVRVEGAIDLDSFLRDVATRSLTISAMAFQDAENLDLERLRGCCISVVSPDGLLVPFCAYNLTSRDGRSLYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UV9</accession>
    <name>Q39UV9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1734</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31965.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1734"/>
    <dbReference type="EnsemblBacteria" id="ABB31965">
        <property type="protein sequence ID" value="ABB31965"/>
        <property type="gene ID" value="Gmet_1734"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1734"/>
    <dbReference type="HOGENOM" id="CLU_3025821_0_0_7"/>
    <dbReference type="OMA" id="HRRGYQF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31965.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="55" mass="6452" checksum="0BFD7F6D4B1E7818" modified="2012-10-31" version="2">MEEAVYKFPFLSVAQVHSFSMDRPVSIVFGPDNMYWVVPDAVARELHRRGYQFCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V01</accession>
    <name>Q39V01_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365860.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1692"/>
    <dbReference type="EnsemblBacteria" id="ABB31923">
        <property type="protein sequence ID" value="ABB31923"/>
        <property type="gene ID" value="Gmet_1692"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1692"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_3_0_7"/>
    <dbReference type="OMA" id="WHGHYVK"/>
    <dbReference type="OrthoDB" id="1786865at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="2">
        <location>
            <begin position="20"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="140" mass="15627" checksum="8CFC7A1CD991D5A1" modified="2005-11-22" version="1">MRHHETQIKVRFNEIDAYRVAWHGHYVAWMEVGRSVLAEQFGLDVESLAAAGFLGPVVNLELKYLQPALLGEMLTVRTSLARGEAATLEFRCTIIGSDGKVRARGKTVHVLTDLDGVLQYQLPQVIGERVERMLAWQGGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V23</accession>
    <name>Q39V23_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1670</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511393.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1670"/>
    <dbReference type="EnsemblBacteria" id="ABB31901">
        <property type="protein sequence ID" value="ABB31901"/>
        <property type="gene ID" value="Gmet_1670"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1670"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="ICVERRC"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="179"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="127"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="394" mass="44131" checksum="5239DC9DC21BC3B8" modified="2005-11-22" version="1">MVENKSVRILYMEDDAGLARLLQRKLQRQSFSVEIARNGDDGLATLGKAPFDVVLLDYSMPSCDGIDVLRIMAECKTSPPVIMLTGRGNEKIAVEALQLGASDYIVKDVDMGYLELLPVVIDQVLQKQQLIREREQMLKALQESEDRYRRLSAQLERMVLERTEDLQTSNRELEVFCYSVSHDLSAPLRTINGFSEVLLEEYGDRLDNAGRRCLSKIGAAATRMVQLIDALLDLSTMATDEPRLEPVNLSDLAGEIAQELHDLEQQHKVDVRITGGMEVEGDPALLRVMMENLLGNAWKFSRTLPDACIEFGKSFQNGEMAYYVRDNGIGFDLGNSGKLIELFQRLHLGDEFKGIGIGLATVQRIVERHNGRIWAESEVGKGATFYFTLSPIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V57</accession>
    <name>Q39V57_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511428.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1636"/>
    <dbReference type="EnsemblBacteria" id="ABB31867">
        <property type="protein sequence ID" value="ABB31867"/>
        <property type="gene ID" value="Gmet_1636"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1636"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102126_0_0_7"/>
    <dbReference type="OMA" id="NIVYDRM"/>
    <dbReference type="OrthoDB" id="1942123at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="235" mass="25695" checksum="16092DFE2A3B140F" modified="2005-11-22" version="1">MEHHPHLHRPARTLFVGTLVLSLALHLSFAALASLFPGRLTGLASESIVMVDLTDAAAPLTKPPVGATAVQRPVSPAQKQMVLPTHEEKALPEPSPTPMEELPPPVPPQTSVSSLSDGLTRGFFRSLADGETLRGDVREYYFELVERVNEQWWDAASGTGMEPGRQEALVTITVRKNGELLDVRLIRSSGNDQYDRLIMDTLQAASNLPPLPDSYPGEFFQAPLRLMAPRGLLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VD9</accession>
    <name>Q39VD9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1551</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511516.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1551"/>
    <dbReference type="EnsemblBacteria" id="ABB31785">
        <property type="protein sequence ID" value="ABB31785"/>
        <property type="gene ID" value="Gmet_1551"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1551"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1872473_0_0_7"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="21"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="136" mass="15070" checksum="5E9C26C4D177E4DB" modified="2005-11-22" version="1">MLNLAHNREEMNSKETWPESGDFLFVTAGKQCATIESLLIRNGLRVTRVENGEEALLVLKDEPWKVLVADALLPDMDGIELTRAALENQPSLLVILGVADPPEDFGKKAAMAGASGIVHKPYEPDQLFPLLWFLMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VG9</accession>
    <name>Q39VG9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl:(R)-benzylsuccinate coenzyme A transferase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bbsE</name>
        <name evidence="1" type="ordered locus">Gmet_1521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365841.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1521"/>
    <dbReference type="DNASU" id="3740121"/>
    <dbReference type="EnsemblBacteria" id="ABB31755">
        <property type="protein sequence ID" value="ABB31755"/>
        <property type="gene ID" value="Gmet_1521"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1521"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_0_0_7"/>
    <dbReference type="OMA" id="ELRNWRL"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="412" mass="45451" checksum="07C25C5F7328EC68" modified="2005-11-22" version="1">MSNTGSLSYLRILDFTGEIGPYAAKLYAGLGADVIHIEPIAGDTLRSTGPFFGNRPGKERSMQFIYYNAGKRGLVLDLKKEKGKEVFVDLCKGADILFESFTPGYLDELGLSFDVLSAANPKLVQTSITPFGSFGPYSTYPGSDLTCSALGGFLYLAGIDNDKPVRACDNQAYRMAEVYAAVGSSIALLFAQKTGVGQFVDVSCMEAVGMALETAAQCWDLEGTLRRGRGKEAGSATIHPCKDGFIAIVAIVGRNKTMWTPFVQWMKEEGVEEWELFDNDNWINASYRESKAGYELFCRIFERFTMKHTKQYLYDAGQAHRVAVSPVSNGKDLLENPQLNHHDFWQRLYHEPVGAEVVCPGAPYEFGHLKWRLGDFAPTFGQHTAEVLGECGYSRSEIDALDREGVVHVAKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VI0</accession>
    <name>Q39VI0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">4-oxalocrotonate tautomerase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511557.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1510"/>
    <dbReference type="EnsemblBacteria" id="ABB31744">
        <property type="protein sequence ID" value="ABB31744"/>
        <property type="gene ID" value="Gmet_1510"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1510"/>
    <dbReference type="eggNOG" id="COG1942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148073_2_1_7"/>
    <dbReference type="OMA" id="PIITLEM"/>
    <dbReference type="OrthoDB" id="2013680at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006725">
        <property type="term" value="P:cellular aromatic compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.429.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004370">
        <property type="entry name" value="4-oxalocrotonate_tautomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014347">
        <property type="entry name" value="Tautomerase/MIF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01361">
        <property type="entry name" value="Tautomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55331">
        <property type="entry name" value="SSF55331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tautomerase" evidence="1">
        <location>
            <begin position="2"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="61" mass="6676" checksum="1763B7317D58B860" modified="2005-11-22" version="1">MPVITIDLAAVTKEKKAQLVQVLTRDASEITGIPEDKFIILINELERDNIGVGGTLLSDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VM3</accession>
    <name>Q39VM3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, M28 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511602.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1467"/>
    <dbReference type="DNASU" id="3740488"/>
    <dbReference type="EnsemblBacteria" id="ABB31701">
        <property type="protein sequence ID" value="ABB31701"/>
        <property type="gene ID" value="Gmet_1467"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1467"/>
    <dbReference type="eggNOG" id="COG2234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048743_0_0_7"/>
    <dbReference type="OMA" id="DHAPFWY"/>
    <dbReference type="OrthoDB" id="1465483at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045175">
        <property type="entry name" value="M28_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12147">
        <property type="entry name" value="PTHR12147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M28" evidence="1">
        <location>
            <begin position="69"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="305" mass="32986" checksum="E87B33208C7D7CA6" modified="2005-11-22" version="1">MREHDEGLLNGITPDRIRDHIRALEGVRHPLAAPEALERAAGYIRETFGSLGYPVADHLFMDGGREFANIIATHTGGSKSGRRVLVVAHYDTVTTTPGADDNASGVAVLLELATILKCLRFERCLQFVAVTLEENEDEHNPRDLGTRGSRALAAHARREGWEIEGAVVLESVAYAGDAVVQRTPAGIPFTVPATGNFIGVIGNEASRGMVDRFGQAVGSREAGLPWVPLVVPGNGGLLPDSRRSDHAPFWDHGYKAIMLTDTTNFRNPHYHQPSDTLETLNLDFAVQVCRATAALLLDIAKASEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VW0</accession>
    <name>Q39VW0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiol:disulfide interchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dsbA</name>
        <name evidence="6" type="ordered locus">Gmet_1380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family. DsbA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513128.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1380"/>
    <dbReference type="EnsemblBacteria" id="ABB31614">
        <property type="protein sequence ID" value="ABB31614"/>
        <property type="gene ID" value="Gmet_1380"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1380"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088255_3_1_7"/>
    <dbReference type="OMA" id="YEVAKIQ"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03019">
        <property type="entry name" value="DsbA_DsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023205">
        <property type="entry name" value="DsbA/DsbL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001488">
        <property type="entry name" value="Tdi_protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0574">Periplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223341" description="Thiol:disulfide interchange protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="DSBA" evidence="5">
        <location>
            <begin position="120"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="54"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001488-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="221" mass="24590" checksum="D2050BA36C28B1F5" modified="2005-11-22" version="1">MSFKFVKTIAKSLALVALFAGSCFAFTEGTDYVKLAKPIPNAQGTLIKVFSYDCPFCYKYDKKITPNLVPKLPSDLKFRPFHLKTKGKYGVQGSELFAVLLLKDQKAGLSDRDLYGPKSLLKKAKMAYYTAYHDKKERWDAGPDAYLKTGLDAVGMSKAEFDKAKADPKVKALLKEWDASYDVAKVQGVPGFVVNGKYLIMTKSITSIDGMLKLINELKTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-05" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VY6</accession>
    <name>SYP_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Prolyl-tRNA synthetase</fullName>
            <shortName evidence="1">ProRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proS</name>
        <name type="ordered locus">Gmet_1354</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365817.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VY6"/>
    <dbReference type="SMR" id="Q39VY6"/>
    <dbReference type="STRING" id="269799.Gmet_1354"/>
    <dbReference type="EnsemblBacteria" id="ABB31588">
        <property type="protein sequence ID" value="ABB31588"/>
        <property type="gene ID" value="Gmet_1354"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1354"/>
    <dbReference type="eggNOG" id="COG0442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016739_0_0_7"/>
    <dbReference type="OMA" id="NCDYAAN"/>
    <dbReference type="OrthoDB" id="665824at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00861">
        <property type="entry name" value="ProRS_anticodon_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00779">
        <property type="entry name" value="ProRS_core_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01569">
        <property type="entry name" value="Pro_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004500">
        <property type="entry name" value="Pro-tRNA-synth_IIa_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023717">
        <property type="entry name" value="Pro-tRNA-Synthase_IIa_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044140">
        <property type="entry name" value="ProRS_anticodon_short"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033730">
        <property type="entry name" value="ProRS_core_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001535">
        <property type="entry name" value="ProRS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00409">
        <property type="entry name" value="proS_fam_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000248697" description="Proline--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01569"/>
        </source>
    </evidence>
    <sequence length="570" mass="63243" checksum="3195E9EDD6C746DC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VZ3</accession>
    <name>Q39VZ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane-associated phosphatase, PAP2_like_5 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1347</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513161.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1347"/>
    <dbReference type="EnsemblBacteria" id="ABB31581">
        <property type="protein sequence ID" value="ABB31581"/>
        <property type="gene ID" value="Gmet_1347"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1347"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059169_1_0_7"/>
    <dbReference type="OrthoDB" id="1930882at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="252"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="392" mass="41402" checksum="FB151221E86A813C" modified="2005-11-22" version="1">MNDSAKKFPSLRFLFLAGWVGTIIWLSLDPSPPHPTVGILGWDKFQHASAYGLLALLWGNFLVTYRRCQRHCWLMAFAGAVVFGALMEVAQGVLTTARTAEFGDLVADAVGAGAVSLAAGAWSARRLSLAFVVAVTLLAGVRGAQADDNGVGAFVRDEAVTLRDETGEFLAAPFRTDNNAIWKTLAVAGAVGLTYIYDTDIRDKVQETRGKTLGRAADAGNVIGNPFVHLGVAGAVWGGGLLADSPRWRDTGLMMGEAAVIADAATLVLKQAVGRARPLTGSSKGSFRPFQFTSDYDSFPSMHTASSFAMASVISRTSGSVPVGVLSYATAAFVGFSRMYEDKHWASDVLLGAVIGELAGRVVTDHYARKGSVTLVPSVSGSSASLMLVKKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W34</accession>
    <name>RSMA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase A</fullName>
            <ecNumber evidence="1">2.1.1.182</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethyladenosine transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">16S rRNA dimethylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmA</name>
        <name evidence="1" type="synonym">ksgA</name>
        <name type="ordered locus">Gmet_1304</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(1518)/adenosine(1519) in 16S rRNA + 4 S-adenosyl-L-methionine = 4 H(+) + N(6)-dimethyladenosine(1518)/N(6)-dimethyladenosine(1519) in 16S rRNA + 4 S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:19609"/>
            <dbReference type="Rhea" id="RHEA-COMP:10232"/>
            <dbReference type="Rhea" id="RHEA-COMP:10233"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.182"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.182" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512062.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W34"/>
    <dbReference type="SMR" id="Q39W34"/>
    <dbReference type="STRING" id="269799.Gmet_1304"/>
    <dbReference type="EnsemblBacteria" id="ABB31540">
        <property type="protein sequence ID" value="ABB31540"/>
        <property type="gene ID" value="Gmet_1304"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1304"/>
    <dbReference type="eggNOG" id="COG0030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041220_0_1_7"/>
    <dbReference type="OMA" id="KEEEPYF"/>
    <dbReference type="OrthoDB" id="2030110at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052908">
        <property type="term" value="F:16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00607">
        <property type="entry name" value="16SrRNA_methyltr_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="PTHR11727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000257292" description="Ribosomal RNA small subunit methyltransferase A">
        <location>
            <begin position="1"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00607"/>
        </source>
    </evidence>
    <sequence length="275" mass="30633" checksum="9B2D2AD63F851042" modified="2005-11-22" version="1">MRGEGIRARKALGQNFLVDRHVLARIADIVDMRPDDRILEVGPGKGALTEMLAHRCARLVAVELDTRLVPVLRQAFRDNPRVEIVHGDILEIDLRDLLAYEGGERWKVAANLPYNISTPVLFAFLDNRDLFSRLVLMLQKEVGDRLAASPGTKDYGILSVFFQLHFDVTREMIVRPGSFHPVPKVDSAVLSFVPLEKPRVAVGDEQYFRRLVKGAFSMRRKTLWNCLKNAGLGLSGEQLSEALAVCGIEPGRRGETLSLDEFAALSRAMMALGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W68</accession>
    <name>Q39W68_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512097.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1270"/>
    <dbReference type="EnsemblBacteria" id="ABB31506">
        <property type="protein sequence ID" value="ABB31506"/>
        <property type="gene ID" value="Gmet_1270"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1270"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043513_0_0_7"/>
    <dbReference type="OMA" id="WPFFGYT"/>
    <dbReference type="OrthoDB" id="739761at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223203" evidence="1">
        <location>
            <begin position="25"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="505" mass="59399" checksum="7676CBCA7D138CEE" modified="2005-11-22" version="1">MRLRILFILCVLAMFLAAPLEASAGDEAEQGTIVTLWPFFDYRESPGNGFSNLSILGPLIKVQQQGGERTTAVRPFVYRTVDEREHSATTSYLYPLASSREAPEVSTFQVLQLLQVNTFRKDEPDKVKSDSMLFPFYIRGKSETYGPYTSVFPFYGTLYERFWRDEIHFTLFPLYSRTVKKDTTTRNYLYPFFSTTSGVGENGFQFWPLYGSAAKEGSYERRFILWPFYFHERKGLDTDNPTERLTVFPLYSATESPRLSSRTYLWPFMGWTSDREAKQEERRYLWPLIMTATGEKRDVKRYLPFYAEERSKETLKRWYLWPLYRHDELASDTYCRDRDRILFFLYSDLREQWPVDHAERRRTTFWPLFVFTRGTHGVKQFSFPALMEPILPQEGIEQSWAPLWRVYIQRWSDSGDSTVSFLWNLYWHERRGNDLAYELFPLVSYRSEGTRADVSVLKGLIRLRQNKGVKTLSLFWLPFGITWDASGEAAAGQESTMTNSARLEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W69</accession>
    <name>Q39W69_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Isopropylmalate/citramalate isomerase, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">leuD</name>
        <name evidence="3" type="ordered locus">Gmet_1269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512098.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1269"/>
    <dbReference type="EnsemblBacteria" id="ABB31505">
        <property type="protein sequence ID" value="ABB31505"/>
        <property type="gene ID" value="Gmet_1269"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1269"/>
    <dbReference type="eggNOG" id="COG0066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081378_1_2_7"/>
    <dbReference type="OMA" id="FEVNGIN"/>
    <dbReference type="OrthoDB" id="1384217at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01577">
        <property type="entry name" value="IPMI_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033940">
        <property type="entry name" value="IPMI_Swivel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase_C" evidence="2">
        <location>
            <begin position="55"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="175" mass="19498" checksum="3A79AFC513FB9C62" modified="2005-11-22" version="1">MKQFGGPVLFLDRADINTDEIIPAKYLTEITKEDLKPYILEDLKLPGFDPKGEKTRSARVIVSRANFGCGSSREHAPWVFEVNGITAVIAESFARIFRQNMFNCGMAAIELPKEKIDLLFSFDNCPDTAIGIDVEKQTLTISGGGRKEIITFDVSPFDRALVLAGGWVDYADQKY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W76</accession>
    <name>ILVC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ketol-acid reductoisomerase (NADP(+))</fullName>
            <shortName evidence="1">KARI</shortName>
            <ecNumber evidence="1">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetohydroxy-acid isomeroreductase</fullName>
            <shortName evidence="1">AHIR</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ketol-acid reductoisomerase type 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Ketol-acid reductoisomerase type I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ilvC</name>
        <name type="ordered locus">Gmet_1262</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512105.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W76"/>
    <dbReference type="SMR" id="Q39W76"/>
    <dbReference type="STRING" id="269799.Gmet_1262"/>
    <dbReference type="EnsemblBacteria" id="ABB31498">
        <property type="protein sequence ID" value="ABB31498"/>
        <property type="gene ID" value="Gmet_1262"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1262"/>
    <dbReference type="eggNOG" id="COG0059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033821_0_1_7"/>
    <dbReference type="OMA" id="RAMFSWL"/>
    <dbReference type="OrthoDB" id="188901at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00435">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014359">
        <property type="entry name" value="KARI_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="PTHR21371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="IlvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="IlvN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000116">
        <property type="entry name" value="IlvC_gammaproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000252761" description="Ketol-acid reductoisomerase (NADP(+))">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="2">
        <location>
            <begin position="1"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="3">
        <location>
            <begin position="182"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="24"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <sequence length="338" mass="36709" checksum="6DB2D6DAB795FDAD" modified="2005-11-22" version="1">MKIYYDKDCNMGVLKGKKVAIIGYGSQGHAHANNLKDSGIDVVVGLRADSASVKKATEAGLTVLPTSEAVKIADVVMILLPDETQGDIYREEIGPFLKQGAYLAFSHGFNIHFGQIVPRPDVNVIMIAPKGPGHLVRHEYTKGGGVPSLIAIHHDPAGNSRDVALAYASANGGGRAGIIETSFKEETETDLFGEQAVLCGGISALIQAGFETLVEAGYAPEMAYFECLHETKLIVDLIYEGGIANMRYSISNTAEYGDLTRGPRVVTDETKKEMKRILDEIQTGQFAKEWMLENKANKPVFTALRRKGAEHQIEEVGARLRSMMSWIGASKIVDKAKN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W85</accession>
    <name>RRF_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome-recycling factor</fullName>
            <shortName evidence="1">RRF</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosome-releasing factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">frr</name>
        <name type="ordered locus">Gmet_1253</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRF family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512114.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W85"/>
    <dbReference type="SMR" id="Q39W85"/>
    <dbReference type="STRING" id="269799.Gmet_1253"/>
    <dbReference type="EnsemblBacteria" id="ABB31489">
        <property type="protein sequence ID" value="ABB31489"/>
        <property type="gene ID" value="Gmet_1253"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1253"/>
    <dbReference type="eggNOG" id="COG0233">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073981_2_0_7"/>
    <dbReference type="OMA" id="FNPMNNG"/>
    <dbReference type="OrthoDB" id="1674344at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006415">
        <property type="term" value="P:translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00520">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00040">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002661">
        <property type="entry name" value="Ribosome_recyc_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023584">
        <property type="entry name" value="Ribosome_recyc_fac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036191">
        <property type="entry name" value="RRF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20982">
        <property type="entry name" value="PTHR20982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01765">
        <property type="entry name" value="RRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55194">
        <property type="entry name" value="SSF55194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00496">
        <property type="entry name" value="frr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000003170" description="Ribosome-recycling factor">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00040"/>
        </source>
    </evidence>
    <sequence length="185" mass="21021" checksum="40A25475F5DA9715" modified="2005-11-22" version="1">MTKEVIADMKAHMEKSVDALRREYQKVRTGRATTGLLDDIKVEYYGNPSPLSQVATLSVPEPRTITIQPWEAKLIPVIEKAIMNANLGFTPANDGKTIRISLPPLTEERRKEIVKTLKKMAEDTKVAVRNIRRDGIDSLKKLEKDKKISEDDLKRAEKEVQDVTNTFVAKVEEVLTHKEKEVLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W97</accession>
    <name>Q39W97_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">frx-1</name>
        <name evidence="5" type="ordered locus">Gmet_1241</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512128.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1241"/>
    <dbReference type="EnsemblBacteria" id="ABB31477">
        <property type="protein sequence ID" value="ABB31477"/>
        <property type="gene ID" value="Gmet_1241"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1241"/>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158022_0_0_7"/>
    <dbReference type="OMA" id="MKGFRYL"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="96" mass="9831" checksum="5675AEC57D7AE70F" modified="2005-11-22" version="1">MKGFSYLTNVASLELNREACIGCGMCVAVCPHGVFALQGNKAEMQDFDACMECGACAVNCPVGAIEVDSGVGCASGMINEWLASIGARKTRGGGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WC4</accession>
    <name>Q39WC4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NACHT domain and WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512157.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1213"/>
    <dbReference type="EnsemblBacteria" id="ABB31450">
        <property type="protein sequence ID" value="ABB31450"/>
        <property type="gene ID" value="Gmet_1213"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1213"/>
    <dbReference type="eggNOG" id="COG2319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_253317_0_0_7"/>
    <dbReference type="OMA" id="WEACERM"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025139">
        <property type="entry name" value="DUF4062"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="G-protein_beta_WD-40_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018391">
        <property type="entry name" value="PQQ_beta_propeller_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13271">
        <property type="entry name" value="DUF4062"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00564">
        <property type="entry name" value="PQQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="SSF50978"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF4062" evidence="5">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="4">
        <location>
            <begin position="355"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="835"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="877"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="919"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="961"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1044"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1045"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1087"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1129"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1171"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1213"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1299"/>
            <end position="1337"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1338"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1416" mass="154925" checksum="61955A3016C8370E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WC9</accession>
    <name>Q39WC9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein YeaQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1208</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0410 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512162.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31445">
        <property type="protein sequence ID" value="ABB31445"/>
        <property type="gene ID" value="Gmet_1208"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1208"/>
    <dbReference type="eggNOG" id="COG2261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160040_0_1_7"/>
    <dbReference type="OMA" id="GGGWWFT"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007341">
        <property type="entry name" value="Transgly_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33884">
        <property type="entry name" value="PTHR33884"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04226">
        <property type="entry name" value="Transgly_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="79" mass="8103" checksum="4480028DA40E67D9" modified="2005-11-22" version="1">MSILWFLLIGIAAGWLAGQLMRGGGFGLAGDLIVGVIGALLGGFLFGLLGLSAYGMLGQLVTATVGAIVLLFVLRLIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WF1</accession>
    <name>Q39WF1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gdhA</name>
        <name evidence="9" type="ordered locus">Gmet_1186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3 7">Belongs to the Glu/Leu/Phe/Val dehydrogenases family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512184.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1186"/>
    <dbReference type="EnsemblBacteria" id="ABB31423">
        <property type="protein sequence ID" value="ABB31423"/>
        <property type="gene ID" value="Gmet_1186"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1186"/>
    <dbReference type="eggNOG" id="COG0334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025763_2_1_7"/>
    <dbReference type="OMA" id="PCFAAFP"/>
    <dbReference type="OrthoDB" id="1184827at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004353">
        <property type="term" value="F:glutamate dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05313">
        <property type="entry name" value="NAD_bind_2_Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006095">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006097">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014362">
        <property type="entry name" value="Glu_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033922">
        <property type="entry name" value="NAD_bind_Glu_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02812">
        <property type="entry name" value="ELFV_dehydrog_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000185">
        <property type="entry name" value="Glu_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00082">
        <property type="entry name" value="GLFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="8">
        <location>
            <begin position="208"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalysis" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000185-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="450" mass="49431" checksum="16B4DD251257494F" modified="2005-11-22" version="1">MSPQLIDERLAGIYQDVLKRNPGEVEFHQAVAEVLESLGPVVTKHPEYLERKIIERIAEPERQIIFRVPWQDDKGQVHINRGFRVEFNSALGPYKGGLRFHPSVYLGIIKFLGFEQIFKNSLTGMPIGGGKGGSDFDPKGKTDDEVMRFCQSFMTELYRHIGEHTDVPAGDIGVGGREIGYMFGQYKRITNRWEAGVLTGKGLKFGGSLVRPEATGYGATYFINEALKVRKDSFDGKTCLVSGSGNVAIYTIEKIHQLGGKCIACSDSNGVIIHEKGLDVELIKQLKEVERRRIADYATYHKDAKYIANGNIWDIPCQVAMPSATQNEINGKDAKTLVKNGCIAVGEGANMPTTPEGIKVFIEAQIAYGPGKAANAGGVATSALEMQQNAQRDSWSFEETEKKLEKIMVGIHKLCYETAEEYGDKGNYVTGANIAGFIKVADAMVAHGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WH2</accession>
    <name>Q39WH2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein Gmet_1164</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513429.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1164"/>
    <dbReference type="EnsemblBacteria" id="ABB31402">
        <property type="protein sequence ID" value="ABB31402"/>
        <property type="gene ID" value="Gmet_1164"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1164"/>
    <dbReference type="eggNOG" id="COG1872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130694_6_0_7"/>
    <dbReference type="OMA" id="AANRECC"/>
    <dbReference type="OrthoDB" id="1997369at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005228">
        <property type="entry name" value="CHP00251"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13420">
        <property type="entry name" value="PTHR13420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00251">
        <property type="entry name" value="TIGR00251"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="102" mass="10845" checksum="0F3CE9664B267A3C" modified="2005-11-22" version="1">MKSDTPSGELRITENADGVTFSVHVQPRASKNGICGIQGDAIKLRLTSPPVEGEANRLCTEYLAKLLKVPKSAVTIIAGDKSRHKTIRVSGATAQAVHNLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WK6</accession>
    <name>Q39WK6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513394.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1130"/>
    <dbReference type="EnsemblBacteria" id="ABB31368">
        <property type="protein sequence ID" value="ABB31368"/>
        <property type="gene ID" value="Gmet_1130"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1130"/>
    <dbReference type="eggNOG" id="ENOG50314QZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076891_1_0_7"/>
    <dbReference type="OMA" id="DIASYLW"/>
    <dbReference type="OrthoDB" id="1825754at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="268" mass="28645" checksum="75D6DED9089805C5" modified="2005-11-22" version="1">MRLPGGILHDGARLRDFAFRPLTGVVELALAEAAGTGASLPAKVTAALAATLEHVGGESPLPATVAELSVADRQVLMGQLAMGLGLGESWLSADCARCGERFDFSVHHSDLPVKEAGEGYPFAEVETSLGPCRFRVPTGADQQAIAEMDDGEAVRLLVGRCLMARPGECGAGGDFTPADLARIEAALETVAPEVAVSVQAACPACGATHVIEVDPYRALFRYSGWELLQEIHILAATYHWSEEEILALPQERRRRYLELIDRARGMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WL4</accession>
    <name>Q39WL4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-methylisocitrate lyase</fullName>
            <shortName evidence="3">2-MIC</shortName>
            <shortName evidence="3">MICL</shortName>
            <ecNumber evidence="3">4.1.3.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">(2R,3S)-2-methylisocitrate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 5" type="primary">prpB</name>
        <name evidence="5" type="ordered locus">Gmet_1122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Involved in the catabolism of short chain fatty acids (SCFA) via the 2-methylcitrate cycle (propionate degradation route). Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate via an alpha-carboxy-carbanion intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 4">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 3 4">Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.30" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513386.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1122"/>
    <dbReference type="EnsemblBacteria" id="ABB31360">
        <property type="protein sequence ID" value="ABB31360"/>
        <property type="gene ID" value="Gmet_1122"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1122"/>
    <dbReference type="eggNOG" id="COG2513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027389_3_2_7"/>
    <dbReference type="OMA" id="QTELWNK"/>
    <dbReference type="OrthoDB" id="1485205at2"/>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019629">
        <property type="term" value="P:propionate catabolic process, 2-methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01939">
        <property type="entry name" value="PrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012695">
        <property type="entry name" value="PrpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02317">
        <property type="entry name" value="prpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="123"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="210"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="304" mass="33249" checksum="1C189C2896FFD277" modified="2005-11-22" version="1">MSEQISAGKLFRRVIDAEKPLQIVGTINAYCAILAEKAGHRAIYLSGAGVANASFGLPDLGIISRSDVLEEVRRITGASPLPLLVDIDTGWGEEFGIDRTIKEMIRAGAAAVHLEDQVEPKRCGHRPNKSIVSTGRMVDRIKAAVDARSDGDLMIMARTDALATAGLDAAVERAALYVEAGAESIFAEGVTDLAMYRRFADAVDVPLLANMTEFGKTPYYTKEQFAAQGVAMVLYPLSAFRAMSRAALEVYETILRAGTQEPVVAAMQPREELYELLHYYDYERKLDRLSSRDGVESGEGREKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WM3</accession>
    <name>Q39WM3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Bidirectional NAD-reducing hydrogenase, diaphorase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hoxU</name>
        <name evidence="9" type="ordered locus">Gmet_1111</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513767.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1111"/>
    <dbReference type="EnsemblBacteria" id="ABB31351">
        <property type="protein sequence ID" value="ABB31351"/>
        <property type="gene ID" value="Gmet_1111"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1111"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_3_7"/>
    <dbReference type="OMA" id="NHVCAVC"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016214">
        <property type="entry name" value="NAD-red_Hydgase_HoxS_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000309">
        <property type="entry name" value="NAD_red_hyd_HoxU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="8">
        <location>
            <begin position="80"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="139"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="238" mass="26305" checksum="CD162BFD574E0D86" modified="2005-11-22" version="1">MSVVTLTIDGELVSGRRGETLLQVIREHGLALPTLCHLEGLSERGGCRLCIVEVEGSPRPMPACSTAAREGMVVRTATDRLIRYRRMIVELLFAERNHYCAVCVSAGNCELQTVAATLGVDHVRYEYLSPRLTMDLSHERFGIDHNRCILCTRCVRVCDEVEGVHTWDVSCRGVRSRVIADLNHPWGRSETCTSCGKCVQVCPTGALFTKGAAVGEMVKDAGMLTRVIEGRDKKGWQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WN3</accession>
    <name>Q39WN3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Outer membrane channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513757.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1101"/>
    <dbReference type="EnsemblBacteria" id="ABB31341">
        <property type="protein sequence ID" value="ABB31341"/>
        <property type="gene ID" value="Gmet_1101"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1101"/>
    <dbReference type="HOGENOM" id="CLU_536135_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="508" mass="57017" checksum="A3F739B75E412951" modified="2005-11-22" version="1">MEKRPVSQLMLNGAWLVKAANGEYLDVEVGKDGAPKRFVTVPVSRVRHLFRFAAPDEWAKGKQCPMLAEPVPMEHAGAVRGVKGAPLAPAVQLPVVVAHDGCMGFRLTLLAETARAMRSLTVSPLHDASRSARGRAMAVELMESIEEKRRFFAIDMNTTTLLQTSSTVGFPQFEGEAKRAFDVIAQQLRFDPHGDRLDEAALDRLHRPNDFSESAWQQVCDQLRLEIHYRFLCKSHFEALTHFVQNVFIANSGVVETVGGLVKLDKNQGVNLLIQGMFSLVAKGVGALPFPGSGVVSGALGALFSWMLQDQGPNAATLAVALVNARDGLADLFNKLITSIQKMQGAVYSDWGKLSEMGMALEREDGSRCWPEEDGDLRREASRLMEISVWKDLVKIKWHHMTSSDDPAFLPRYTEADKQAYESKNRNYWVEYRAGTETNLFGKKSNGFYVTYHWLGYGNMWVWHHEPDNAMCDRLFTKLKVTRQEVFTDTSWNLGRETFLVQNYPVPM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WV0</accession>
    <name>ACKA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetate kinase</fullName>
            <ecNumber evidence="1">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ackA</name>
        <name type="ordered locus">Gmet_1034</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Mg(2+). Can also accept Mn(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513207.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39WV0"/>
    <dbReference type="SMR" id="Q39WV0"/>
    <dbReference type="STRING" id="269799.Gmet_1034"/>
    <dbReference type="EnsemblBacteria" id="ABB31274">
        <property type="protein sequence ID" value="ABB31274"/>
        <property type="gene ID" value="Gmet_1034"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1034"/>
    <dbReference type="eggNOG" id="COG0282">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020352_0_1_7"/>
    <dbReference type="OMA" id="FMMQKEN"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006082">
        <property type="term" value="P:organic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000002233" description="Acetate kinase">
        <location>
            <begin position="1"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="208"/>
            <end position="212"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00020"/>
        </source>
    </evidence>
    <sequence length="421" mass="46890" checksum="E694864FF4B47936" modified="2005-11-22" version="1">MVILALNCGSSSVKYQLFDWEKKEVVAKGMVERVIIGDSFIMHEVPGRETYRKEYECPDHKVAIDLIIRTLVDGEHGVLKDINEISAVGHRVVHGGEMFTRSVLIDEKVLDAVKDVQHLAPLHNPPNIAGIEAAQAVLPSVPHVAIFDTAFHQTMPEHAYLYPLPYEWYEKYGVRRYGFHGTSHLFVSKRAAVLLGKKPSDCNIITMHIGNGVSHCAIRGGVSIDTSMGLTPLEGAVMGTRCGDIDPAIPAFMMQKENLSAKEIDSILNKKSGVLGVTGRFTDRRDVIENANNGDHRCKVALEIEAYRLKKYIGTYMAVLGRLDAVVFTAGVGEMGWPIREKTIEGLEGIGIKLDRERNKSAMTRKRETLITTDDSPIKVFVIPTDEELVFTEDVVAILDGTYTDHMNFDYSFARQDFVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WV7</accession>
    <name>Q39WV7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Winged-helix transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1026</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513197.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1026"/>
    <dbReference type="EnsemblBacteria" id="ABB31267">
        <property type="protein sequence ID" value="ABB31267"/>
        <property type="gene ID" value="Gmet_1026"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1026"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_7"/>
    <dbReference type="OMA" id="QLWGYPP"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="224" mass="25200" checksum="414031AE42D8FA15" modified="2005-11-22" version="1">MKILIIEDEKRMAGILKKGLEENAFIVDLAGDGEEGLYMAENYPYDAVLLDIMLPVMDGLSILSALRSKRSEVPVLLITARGEIESRIKGLNFGADDYIVKPFDFHELLARLKSVIRRSKGRPSPLVAIDDLSLDTNSRSVCRGGREIRLSATEYNLLEYLALNSGRVISRTELTEHIYDTDFDRDSNVIDVYVNHLRNKLDKGFDRQLIHTVRGAGYILKGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X40</accession>
    <name>Q39X40_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">DNA repair protein RecN</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Recombination protein N</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">recN</name>
        <name evidence="7" type="ordered locus">Gmet_0942</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">May be involved in recombinational repair of damaged DNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RecN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514425.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0942"/>
    <dbReference type="EnsemblBacteria" id="ABB31184">
        <property type="protein sequence ID" value="ABB31184"/>
        <property type="gene ID" value="Gmet_0942"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0942"/>
    <dbReference type="eggNOG" id="COG0497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018297_3_1_7"/>
    <dbReference type="OMA" id="QVICVTH"/>
    <dbReference type="OrthoDB" id="1074831at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004604">
        <property type="entry name" value="DNA_recomb/repair_RecN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11059">
        <property type="entry name" value="PTHR11059"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003128">
        <property type="entry name" value="RecN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00634">
        <property type="entry name" value="recN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC_N" evidence="6">
        <location>
            <begin position="2"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR003128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="554" mass="60198" checksum="8AE4967CACC789AA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X59</accession>
    <name>Q39X59_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">D,D-heptose 1,7-bisphosphate phosphatase</fullName>
            <ecNumber evidence="5">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gmhB</name>
        <name evidence="10" type="ordered locus">Gmet_0923</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the gmhB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513953.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0923"/>
    <dbReference type="EnsemblBacteria" id="ABB31165">
        <property type="protein sequence ID" value="ABB31165"/>
        <property type="gene ID" value="Gmet_0923"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0923"/>
    <dbReference type="eggNOG" id="COG0241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085077_2_1_7"/>
    <dbReference type="OMA" id="DHPMRKP"/>
    <dbReference type="OrthoDB" id="1472357at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004446">
        <property type="entry name" value="Heptose_bisP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006543">
        <property type="entry name" value="Histidinol-phos"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42891">
        <property type="entry name" value="PTHR42891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004682">
        <property type="entry name" value="GmhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00213">
        <property type="entry name" value="GmhB_yaeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01656">
        <property type="entry name" value="Histidinol-ppas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="22"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="7">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="8">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to substrate recognition" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="site" description="Stabilizes the phosphoryl group" evidence="8">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR004682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR004682-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="192" mass="20770" checksum="C3A516C69E0DA305" modified="2005-11-22" version="1">MVRSEEGRAAVFLDRDGTINVEKEYLHRAEEFEFVPGAPEAIRLLNEAGFLVVVVTNQSGVARGYYDEAAVHRLHRFVDNELAKAGASIDAYYLCPHHPRHGIGPYLTECACRKPLPGMLLAAARDLGIDLARSWIVGDKAADVEAGIAAGCRPLLVRTGYGISEAGQVPSDVTVCDDLLAAARVILARTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X80</accession>
    <name>Q39X80_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carboxynorspermidine/carboxyspermidine dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513932.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0902"/>
    <dbReference type="EnsemblBacteria" id="ABB31144">
        <property type="protein sequence ID" value="ABB31144"/>
        <property type="gene ID" value="Gmet_0902"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0902"/>
    <dbReference type="eggNOG" id="COG1748">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032114_0_0_7"/>
    <dbReference type="OMA" id="KHHFDEI"/>
    <dbReference type="OrthoDB" id="1006830at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacchrp_dh_NADP" evidence="1">
        <location>
            <begin position="4"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Sacchrp_dh_C" evidence="2">
        <location>
            <begin position="137"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="397" mass="44172" checksum="BE90BA135BB7CDD4" modified="2005-11-22" version="1">MSKVLIIGAGGVGQVVAHKCAQRRDIFSEITLASRTKSKCDAIAAQLNNTIATAQVNADNVPELVALIRKEQPKLVINVALPYQDLTIMDACLETGVDYLDTANYEPLDTAKFEYSWQWAYQERFKAAGLMALLGSGFDPGVTNVYTALAAKKYLDEVEELDIIDANAGSHGQPFATNFNPEINIREVTAVCRHWENGQFVESPPLSTKRVFDFPEGIGPMNIYRLYHEEMESIVKHIPTIKKAQFWMTFSDNYLKHLEVLQNVGMTRIDEVEFQGQKIVPIQFLKALLPDPGSLGPLTKGKTCIGVIARGLKDGKRKQVYIYNICDHEACYKEVQSQAISYTTGVPAVVGAIMMLTGKWHAPGVWNMEQFDPEVFLKELGPMGLPEVAVEGEWPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X94</accession>
    <name>Q39X94_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, U32 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513035.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0888"/>
    <dbReference type="MEROPS" id="U32.002"/>
    <dbReference type="EnsemblBacteria" id="ABB31130">
        <property type="protein sequence ID" value="ABB31130"/>
        <property type="gene ID" value="Gmet_0888"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0888"/>
    <dbReference type="eggNOG" id="COG0826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011540_0_2_7"/>
    <dbReference type="OMA" id="YGGVSHF"/>
    <dbReference type="OrthoDB" id="1264653at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032525">
        <property type="entry name" value="Peptidase_U32_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16325">
        <property type="entry name" value="Peptidase_U32_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01276">
        <property type="entry name" value="PEPTIDASE_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_U32_C" evidence="1">
        <location>
            <begin position="319"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="403" mass="45243" checksum="4A7DC6D47EC8FF73" modified="2005-11-22" version="1">MKIPELLAPAGNLEKLKVAIHYGADAVYLGGEKFGLRSLADNFTLAHMAEGIAYAHDRGVKVYLTVNAFPDNSELEDLDRYLEGVATVPFDAYIAADPGVIAAIRRISPDRPIHLSTQANTTNWRSVLFWQKQGIARVNLAREMSLDAIRETRERVTAELEVFVHGALCVSYSGRCLLSSVMTGRNANKGECAHPCRWSYALVEETRPGEYFPVVEDERGTFIFNSKDLCLIRHIPELVGAGADSLKIEGRMKGIHYVASVVRVYREALDSYAADPRAWHMQSEWLEELSKISHRGYTTGFFLGKPVDVDLEFDSRYRRSHEFVGVVEEAHPDGTVTVEVRNRIVAGTTVEVIGRRMRSTLHRLDAFTDMDGNSLSEAHPNQRIRVSLPVAAERYDLIRREKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XL2</accession>
    <name>Q39XL2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Phosphoenolpyruvate synthase</fullName>
            <shortName evidence="10">PEP synthase</shortName>
            <ecNumber evidence="6 10">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">ppsA</name>
        <name evidence="14" type="ordered locus">Gmet_0770</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 10">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 10">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="6 10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513515.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0770"/>
    <dbReference type="EnsemblBacteria" id="ABB31012">
        <property type="protein sequence ID" value="ABB31012"/>
        <property type="gene ID" value="Gmet_0770"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0770"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_6_2_7"/>
    <dbReference type="OMA" id="LETWFFL"/>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000854">
        <property type="entry name" value="PEP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01418">
        <property type="entry name" value="PEP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPDK_N" evidence="12">
        <location>
            <begin position="16"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="11">
        <location>
            <begin position="388"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="13">
        <location>
            <begin position="485"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB31012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="800" mass="88595" checksum="1C9CAC0C11886C09" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XX9</accession>
    <name>RPOA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit alpha</fullName>
            <shortName evidence="1">RNAP subunit alpha</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoA</name>
        <name type="ordered locus">Gmet_0653</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase alpha chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514261.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XX9"/>
    <dbReference type="SMR" id="Q39XX9"/>
    <dbReference type="STRING" id="269799.Gmet_0653"/>
    <dbReference type="EnsemblBacteria" id="ABB30895">
        <property type="protein sequence ID" value="ABB30895"/>
        <property type="gene ID" value="Gmet_0653"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0653"/>
    <dbReference type="eggNOG" id="COG0202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053084_0_1_7"/>
    <dbReference type="OMA" id="LMKFRNF"/>
    <dbReference type="OrthoDB" id="662686at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00059">
        <property type="entry name" value="RNApol_bact_RpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011773">
        <property type="entry name" value="DNA-dir_RpoA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011260">
        <property type="entry name" value="RNAP_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32108">
        <property type="entry name" value="PTHR32108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03118">
        <property type="entry name" value="RNA_pol_A_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="SSF55257"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="SSF56553"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02027">
        <property type="entry name" value="rpoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000264502" description="DNA-directed RNA polymerase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha N-terminal domain (alpha-NTD)" evidence="1">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Alpha C-terminal domain (alpha-CTD)" evidence="1">
        <location>
            <begin position="251"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00059"/>
        </source>
    </evidence>
    <sequence length="340" mass="37873" checksum="78B3CF8C605CDCE0" modified="2005-11-22" version="1">MYRNWRDLISPKKLQVESESLTNTYGKFFAEPFERGFGTTLGNSLRRVLLSSLQGAAISSVKIKGVLHEFSSIPGVTEDVTNIILNLKGVSLKMHGNEARTVRIIHKGDGIVKAGDIVTDANVEILNPDHHIATCSKDANLEMEMVVKLGKGYVPSDRNRDEKAPVGTMPIDAIFSPIKKVNFTVSNARVGQMTDYDKLTLEVWTNGSVVPEDAVAFAAKILKEQLSIFINFDEEAEPAEEAETEEERERVNENLYRSVDELELSVRSANCLKNAGIKMIGELVSRSEAEMLKTQNFGRKSLNEIKDILADMGLTLGMKLDGFPDPEVMRRIRGERKDEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XZ6</accession>
    <name>RL14_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplN</name>
        <name type="ordered locus">Gmet_0636</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514246.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XZ6"/>
    <dbReference type="SMR" id="Q39XZ6"/>
    <dbReference type="STRING" id="269799.Gmet_0636"/>
    <dbReference type="EnsemblBacteria" id="ABB30878">
        <property type="protein sequence ID" value="ABB30878"/>
        <property type="gene ID" value="Gmet_0636"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0636"/>
    <dbReference type="eggNOG" id="COG0093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095071_2_1_7"/>
    <dbReference type="OMA" id="AKEVLCI"/>
    <dbReference type="OrthoDB" id="1799923at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_L14_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_L14P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005745">
        <property type="entry name" value="Ribosomal_L14P_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019972">
        <property type="entry name" value="Ribosomal_L14P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="PTHR11761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="SSF50193"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01067">
        <property type="entry name" value="rplN_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00049">
        <property type="entry name" value="RIBOSOMAL_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000266489" description="50S ribosomal protein L14">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01367"/>
        </source>
    </evidence>
    <sequence length="122" mass="13354" checksum="A30EBF93B1A022BC" modified="2005-11-22" version="1">MIQMQTILDVADNSGARKLFCIKVLGGSKRKYAGIGDIIVASVREAIPNSKVKKGDVVKAVIVRTAKEVGRLDGSYIRFDDNSAVVINNQREPVGTRIFGPVARELRARKFMKIVSLAPEVL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XZ8</accession>
    <name>RL29_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmC</name>
        <name type="ordered locus">Gmet_0634</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514244.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XZ8"/>
    <dbReference type="SMR" id="Q39XZ8"/>
    <dbReference type="STRING" id="269799.Gmet_0634"/>
    <dbReference type="EnsemblBacteria" id="ABB30876">
        <property type="protein sequence ID" value="ABB30876"/>
        <property type="gene ID" value="Gmet_0634"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0634"/>
    <dbReference type="eggNOG" id="COG0255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158491_5_2_7"/>
    <dbReference type="OMA" id="RFQMATS"/>
    <dbReference type="OrthoDB" id="2063644at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_L29/L35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_L29/L35_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018254">
        <property type="entry name" value="Ribosomal_L29_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="SSF46561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00579">
        <property type="entry name" value="RIBOSOMAL_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000194019" description="50S ribosomal protein L29">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00374"/>
        </source>
    </evidence>
    <sequence length="62" mass="7092" checksum="8F1E86ACDCF39183" modified="2005-11-22" version="1">MKASDLKNMSVEELTAKNVELTKELFNLRFQLHTGRLENTAKISAVKKDIARVNTFLSERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y89</accession>
    <name>Q39Y89_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhageMetallopep domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0542</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365678.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0542"/>
    <dbReference type="EnsemblBacteria" id="ABB30785">
        <property type="protein sequence ID" value="ABB30785"/>
        <property type="gene ID" value="Gmet_0542"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0542"/>
    <dbReference type="eggNOG" id="COG4900">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105742_0_0_7"/>
    <dbReference type="OMA" id="MWLERPG"/>
    <dbReference type="OrthoDB" id="1688854at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043998">
        <property type="entry name" value="Put_Metallopep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18894">
        <property type="entry name" value="PhageMetallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhageMetallopep" evidence="1">
        <location>
            <begin position="11"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="196" mass="22334" checksum="4FBFAC1CA7A598C3" modified="2005-11-22" version="1">MGGTVLNLTRELEQLVTHIAGHVPEMCHIDPSRLLICISSTRSGGIRGTYAKIHPLRFPGGAKSIERQRGRHTYRSTMPSVTHRGNEILYVIYFLVPRFFDLTPREKLITIFHELFHISPAFDGDIRRFPGRNFAHGSSTRKFNAYMGTLVDAYLAEHGEPAIPAFLDGTMAELRNRHHTIVGRRFRIPLIKTERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YB3</accession>
    <name>Q39YB3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Redox-active disulfide protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512214.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0518"/>
    <dbReference type="EnsemblBacteria" id="ABB30761">
        <property type="protein sequence ID" value="ABB30761"/>
        <property type="gene ID" value="Gmet_0518"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0518"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_18_2_7"/>
    <dbReference type="OMA" id="KYGVMST"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005243">
        <property type="entry name" value="Redox_disulphide_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36450">
        <property type="entry name" value="PTHR36450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13192">
        <property type="entry name" value="Thioredoxin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037031">
        <property type="entry name" value="Redox_disulphide_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00412">
        <property type="entry name" value="redox_disulf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="13"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="2">
        <location>
            <begin position="10"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR037031-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR037031-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="75" mass="8176" checksum="62FFC15C6C60F01D" modified="2005-11-22" version="1">MKIEVLGTGCAKCKTLYENAKKAVEMSGKEAEVIKVEEIQKIMKYGVMRTPALVVDGVVKFSGKVASPDEIRGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YE4</accession>
    <name>Q39YE4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonine-phosphate decarboxylase</fullName>
            <ecNumber evidence="5">4.1.1.81</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">L-threonine-O-3-phosphate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cobD</name>
        <name evidence="11" type="ordered locus">Gmet_0487</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + O-phospho-L-threonine = (R)-1-aminopropan-2-yl phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:11492"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58563"/>
            <dbReference type="ChEBI" id="CHEBI:58675"/>
            <dbReference type="EC" id="4.1.1.81"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.81" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0487"/>
    <dbReference type="EnsemblBacteria" id="ABB30730">
        <property type="protein sequence ID" value="ABB30730"/>
        <property type="gene ID" value="Gmet_0487"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0487"/>
    <dbReference type="eggNOG" id="COG0079">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_3_2_7"/>
    <dbReference type="OMA" id="RDPWSVN"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048472">
        <property type="term" value="F:threonine-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005860">
        <property type="entry name" value="CobD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01140">
        <property type="entry name" value="L_thr_O3P_dcar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="10">
        <location>
            <begin position="26"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="399" mass="43695" checksum="1693D527AB318494" modified="2005-11-22" version="1">MKETFDHGGTVFAVARQLGVSPDEILDFSASINPLGPPVEARGAVAAAFDRLVHYPDSGATELRDALARRHHLLPENICVANGSTELIYLVPRLVGGRRGLIVAPPFSEYAKGLSRAGWEIDYLDLSPADCFTLHLEALDQRLAKGCDLLFLANPGNPTGALIPREVIVEVVSLCRRHGTFLVLDEAFIDFCEEESATDLVVAGEGAVVLRSMTKFYAIPGLRLGYAMGSEEVIARLSALREPWSVNTLAQAAGLACLADGEYPARTRALVETEREWLSAGIARLPGLAVYPSAANYLLVRIDAGPTAPELATRLLAERVLIRDCSSFRGLSERFFRVAVRGTEENRRLLELLGRVFAVDITRKHRATVFSVNKLVQKWSEFRVIPLLVVFHHGIEDGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YJ6</accession>
    <name>Q39YJ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar rod-binding protein FlgJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flgJ</name>
        <name evidence="3" type="ordered locus">Gmet_0435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512407.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0435"/>
    <dbReference type="EnsemblBacteria" id="ABB30678">
        <property type="protein sequence ID" value="ABB30678"/>
        <property type="gene ID" value="Gmet_0435"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0435"/>
    <dbReference type="eggNOG" id="COG3951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155700_1_0_7"/>
    <dbReference type="OMA" id="KLTGGGH"/>
    <dbReference type="OrthoDB" id="1931346at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019301">
        <property type="entry name" value="Flagellar_prot_FlgJ_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10135">
        <property type="entry name" value="Rod-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rod-binding" evidence="2">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="121" mass="13153" checksum="7D0AC440FA2CFDF3" modified="2005-11-22" version="1">MQTSISPDTLVQESDASRARQLAARKDNAKAARKVAQEFEAMFVGMMLKSMRETVGKDKLTGGGKGEEMFQSMLDQEYSTAIATSQGGIGLASMIEKQLVREAAPRGEKTPVTVLKGREKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YK4</accession>
    <name>Q39YK4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flagellar biosynthesis protein FlhF</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Flagella-associated GTP-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">flhF</name>
        <name evidence="12" type="ordered locus">Gmet_0427</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512399.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0427"/>
    <dbReference type="EnsemblBacteria" id="ABB30670">
        <property type="protein sequence ID" value="ABB30670"/>
        <property type="gene ID" value="Gmet_0427"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0427"/>
    <dbReference type="eggNOG" id="COG1419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_11_4_7"/>
    <dbReference type="OMA" id="FFAADMR"/>
    <dbReference type="OrthoDB" id="1162441at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020006">
        <property type="entry name" value="FlhF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF3">
        <property type="entry name" value="PTHR43134:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03499">
        <property type="entry name" value="FlhF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="10">
        <location>
            <begin position="256"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="SRP54" evidence="11">
        <location>
            <begin position="257"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB30670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="452" mass="49156" checksum="B04FD48AAEC86C86" modified="2005-11-22" version="1">MLVKTFEAVDMSEALRKVKAELGPDAMIISSKKEKRGGILGFFSKEVVQVTAGIEMKPRQPAPSQNPYREAQEETLSAKEMMENSMLGPLARELKDLRERVEVLTRKETAAKAQAASQVLPAAPVVEKVVPSPPADSVPKTIQKQDLEEMKKLLFKTLAAKEAGEGVTPAEKAEVLAKPAAAPADGGKGGFKGTLRVIMSELHRKGLERGSVRAVMEQVEPEAKKGGTVEALRSFLPNAFTSVIKCAGPVAFKKNSPRIVALVGPTGVGKTTTIAKLAAHYALRENHRAALITIDNFRVGAVEQLKTYSRIMGVPVEVASTPAELEAAIELHSDKELILIDTAGRSHKDNEKIEELKGFLESRFAIEIHLCLAATTRDREILEVVERFGVLPISRVIFTKLDESESYGTIVNAHLRTKFPLSYFTTGQRVPEDLEIATPGRVAGLVLGEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YL3</accession>
    <name>Q39YL3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512390.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0418"/>
    <dbReference type="EnsemblBacteria" id="ABB30661">
        <property type="protein sequence ID" value="ABB30661"/>
        <property type="gene ID" value="Gmet_0418"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0418"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_3_3_7"/>
    <dbReference type="OMA" id="PESYNWS"/>
    <dbReference type="OrthoDB" id="970297at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="242"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="557" mass="61694" checksum="637DE0AE565ACA3A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YM8</accession>
    <name>MRAZ_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName>Transcriptional regulator MraZ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mraZ</name>
        <name type="ordered locus">Gmet_0403</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Forms oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MraZ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365663.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YM8"/>
    <dbReference type="SMR" id="Q39YM8"/>
    <dbReference type="STRING" id="269799.Gmet_0403"/>
    <dbReference type="EnsemblBacteria" id="ABB30646">
        <property type="protein sequence ID" value="ABB30646"/>
        <property type="gene ID" value="Gmet_0403"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0403"/>
    <dbReference type="eggNOG" id="COG2001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107907_0_5_7"/>
    <dbReference type="OMA" id="FFYSGAS"/>
    <dbReference type="OrthoDB" id="1684767at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16321">
        <property type="entry name" value="MraZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16320">
        <property type="entry name" value="MraZ_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01008">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003444">
        <property type="entry name" value="MraZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035644">
        <property type="entry name" value="MraZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020603">
        <property type="entry name" value="MraZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035642">
        <property type="entry name" value="MraZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038619">
        <property type="entry name" value="MraZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34701">
        <property type="entry name" value="PTHR34701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02381">
        <property type="entry name" value="MraZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00242">
        <property type="entry name" value="TIGR00242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000230086" description="Transcriptional regulator MraZ">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 1" evidence="2">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="SpoVT-AbrB 2" evidence="2">
        <location>
            <begin position="91"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <sequence length="158" mass="17703" checksum="B27A8322BD16EB68" modified="2005-11-22" version="1">MFRGIYETTIDAKGRTSLPARFRDVLVESFGDERFFVTNSVPVDLGGGVYSSGLLIFPYQEWFIFEESFLNGKGLTSAQRNSIMRTIVAPAVECSADKLGRVLVPPHLRKNAVLEREILFVGAMKKVEIWSQSEWDKVRAHDMKAFPSDSEAVAELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YQ6</accession>
    <name>Q39YQ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ech-hydrogenase-related complex, NuoL-like integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ehrA-2</name>
        <name evidence="4" type="ordered locus">Gmet_0375</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512347.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0375"/>
    <dbReference type="EnsemblBacteria" id="ABB30618">
        <property type="protein sequence ID" value="ABB30618"/>
        <property type="gene ID" value="Gmet_0375"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0375"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_8_1_7"/>
    <dbReference type="OMA" id="AMCFVKV"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="650"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="142"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="669" mass="70576" checksum="D9F1119008E372AF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YR2</accession>
    <name>Q39YR2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ech-hydrogenase-related complex, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ehrS-2</name>
        <name evidence="6" type="ordered locus">Gmet_0369</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FrhG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365661.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0369"/>
    <dbReference type="EnsemblBacteria" id="ABB30612">
        <property type="protein sequence ID" value="ABB30612"/>
        <property type="gene ID" value="Gmet_0369"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0369"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055737_5_1_7"/>
    <dbReference type="OMA" id="CLFCPEC"/>
    <dbReference type="OrthoDB" id="1904620at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="31"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="262" mass="27615" checksum="B1EF29737DEE6F7B" modified="2005-11-22" version="1">MLKALFARRHQGHRTIAYPAGPAQLPELFRGAPFLDPEMCPGGCADCANACPHGAITAGTGDQGPGTGKTLALDMGKCLFCPECAGACPHGAISFTGDHRLAVNRREDLIVRSGEVRRLAPPLDATRQFLFSHSLKLREVSAGGCNACEADTNVLSTVGFDLGRFGIQFVASPRHADGIFITGPVTENMHLALLKTWEAIPEPKIAIAAGACAINGGPFIDSPDVHNGADGLIPIDLYIPGCPPHPLTILDGLLRILGRLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YX4</accession>
    <name>Q39YX4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0305</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + ADP + oxaloacetate + phosphate = ATP + citrate + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514017.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0305"/>
    <dbReference type="EnsemblBacteria" id="ABB30550">
        <property type="protein sequence ID" value="ABB30550"/>
        <property type="gene ID" value="Gmet_0305"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0305"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_636056_0_0_7"/>
    <dbReference type="OMA" id="HIEENWD"/>
    <dbReference type="OrthoDB" id="316012at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp_2" evidence="5">
        <location>
            <begin position="29"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Citrate_bind" evidence="6">
        <location>
            <begin position="244"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="423" mass="46798" checksum="7DFAD02F0FBFC880" modified="2005-11-22" version="1">MQLTGLKYGRRLLDLVEFPVSQVLTEDASHDEINELIASHGGKCIVKPVFLGGVGKKGKAGLVRICSNVFDAMVAKRDLFFATHHQGNREVQACGVTFEGYIASDIEIYVSISESSEYRMPVLLLTTKGGVDVEDVPPEDKRTIVFNPVTGVKSFHINDALRELKCPPQYISSLVQHLPKLWQVYDNYGLTTLELNPIRMGKVKGRYVPFACDIKASFDQDNPAWKRLGYPEEIFSTTITQFESEINVLRTHQGQSDVTEVNPKGTILPFIFGGGANSAATEILADRAIISSDFGGNPPYEKIRAIADITFKHWLPQANVVLLIGGRANNTNIFTTFKAIFDSLREHIRLNPDVFVVAGRGGPMVVEGMVYGRDVLDSLRVPYRFFGHDSSMMSVLQHAIEIDSFLEPKPVAVAPKQIKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YX7</accession>
    <name>Q39YX7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin sulfurtransferase MOSC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mosC-1</name>
        <name evidence="2" type="ordered locus">Gmet_0302</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514013.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0302"/>
    <dbReference type="EnsemblBacteria" id="ABB30547">
        <property type="protein sequence ID" value="ABB30547"/>
        <property type="gene ID" value="Gmet_0302"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0302"/>
    <dbReference type="eggNOG" id="COG2258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122785_1_0_7"/>
    <dbReference type="OMA" id="IGKECHN"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="19"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="146" mass="15527" checksum="204477589F739812" modified="2005-11-22" version="1">MSAKVIAVCISENKGERKTPVASVELRENHGIVGDAHAGEWHRQVSLLAAESIEKMRKMGLDVDSGDFAENITTEGIDLPALPVGTRLAVGETLLEVTQIGKECHTRCAIYHQAGDCVMPKEGIFARVITGGVVRPGDPIAVVRGG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z11</accession>
    <name>MSRA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide methionine sulfoxide reductase MsrA</fullName>
            <shortName evidence="1">Protein-methionine-S-oxide reductase</shortName>
            <ecNumber evidence="1">1.8.4.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Peptide-methionine (S)-S-oxide reductase</fullName>
            <shortName evidence="1">Peptide Met(O) reductase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">msrA</name>
        <name type="ordered locus">Gmet_0268</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(S)-S-oxide-[protein]</text>
            <dbReference type="Rhea" id="RHEA:14217"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="Rhea" id="RHEA-COMP:12313"/>
            <dbReference type="Rhea" id="RHEA-COMP:12315"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16044"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:44120"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]-dithiol + L-methionine (S)-S-oxide</text>
            <dbReference type="Rhea" id="RHEA:19993"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58772"/>
            <dbReference type="EC" id="1.8.4.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MsrA Met sulfoxide reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513585.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z11"/>
    <dbReference type="SMR" id="Q39Z11"/>
    <dbReference type="STRING" id="269799.Gmet_0268"/>
    <dbReference type="EnsemblBacteria" id="ABB30513">
        <property type="protein sequence ID" value="ABB30513"/>
        <property type="gene ID" value="Gmet_0268"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0268"/>
    <dbReference type="eggNOG" id="COG0225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031040_10_2_7"/>
    <dbReference type="OMA" id="AGPFYYA"/>
    <dbReference type="OrthoDB" id="1554384at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033744">
        <property type="term" value="F:L-methionine:thioredoxin-disulfide S-oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008113">
        <property type="term" value="F:peptide-methionine (S)-S-oxide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01401">
        <property type="entry name" value="MsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002569">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036509">
        <property type="entry name" value="Met_Sox_Rdtase_MsrA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01625">
        <property type="entry name" value="PMSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55068">
        <property type="entry name" value="SSF55068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00401">
        <property type="entry name" value="msrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000087349" description="Peptide methionine sulfoxide reductase MsrA">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01401"/>
        </source>
    </evidence>
    <sequence length="162" mass="18480" checksum="17791AB0C943D00C" modified="2005-11-22" version="1">MDETPELEKATFGAGCFWHVEAEFRRVSGVVATHAGYMGGWKDHPTYEEVCSKETGHAEVVEVVYDPARVSYDELLRIFWTIHDPTQLNRQGPDIGTNYRSVIFFHTPEQEQAARLSMEKEGGSGRYSRPIVTEIASASAFWWAEEYHQQYLEKRGGGSCNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z21</accession>
    <name>Q39Z21_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA dihydrouridine synthase-like flavin mononucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0258</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0258"/>
    <dbReference type="EnsemblBacteria" id="ABB30503">
        <property type="protein sequence ID" value="ABB30503"/>
        <property type="gene ID" value="Gmet_0258"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0258"/>
    <dbReference type="eggNOG" id="COG0042">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013299_6_0_7"/>
    <dbReference type="OMA" id="YRPPAHW"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dus" evidence="2">
        <location>
            <begin position="26"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="331" mass="35649" checksum="DF1E7AEB74CC2A62" modified="2005-11-22" version="1">MHDTTPSPVTTPRTPLPWPTGHTPLMLAPMQGLTNRALRALFINWVRPDVVFTEFMRVNPGGARQPIRAGDLREVAAVEGGVPLVVQLIGHDHKALVAAARTAQEAGAVHINLNLGCPYGRMTSGLTGGGMLHRPEALEELIPALRRAIAGTFSVKVRAGYDDSGQIMTLLPLFEEAGVDFLVLHPRTVVQEYTGHADHAVTAEVVRQTRLPVIANGDVRSAADGLRVLRKTGATGLMLGRGAIADPLLFQRLRGKAPAEPTGEERVAMLKRYLGELLEGYGEIFCGDTQILGKIKGVMATMDDPFLAKGLKQLKKARTVAAFASTLRDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z58</accession>
    <name>Q39Z58_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512809.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0220"/>
    <dbReference type="EnsemblBacteria" id="ABB30466">
        <property type="protein sequence ID" value="ABB30466"/>
        <property type="gene ID" value="Gmet_0220"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0220"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_187660_0_0_7"/>
    <dbReference type="OMA" id="MNTIPAQ"/>
    <dbReference type="OrthoDB" id="2072343at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="89" mass="9980" checksum="58FF1472DC614546" modified="2005-11-22" version="1">MNTIPAQELKRRGIAAVDGLIESGDVHVIRNNRPEYVILSEERYRELVAEAEEAYLARVRASLEDVKAGRVRRFASADELLQALDAEGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z66</accession>
    <name>DAPB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-tetrahydrodipicolinate reductase</fullName>
            <shortName evidence="1">HTPA reductase</shortName>
            <ecNumber evidence="1">1.17.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapB</name>
        <name type="ordered locus">Gmet_0212</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NAD(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:35323"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-2,3,4,5-tetrahydrodipicolinate + H2O + NADP(+) = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:35331"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:67139"/>
            <dbReference type="EC" id="1.17.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512801.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z66"/>
    <dbReference type="SMR" id="Q39Z66"/>
    <dbReference type="STRING" id="269799.Gmet_0212"/>
    <dbReference type="EnsemblBacteria" id="ABB30458">
        <property type="protein sequence ID" value="ABB30458"/>
        <property type="gene ID" value="Gmet_0212"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0212"/>
    <dbReference type="eggNOG" id="COG0289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047479_2_1_7"/>
    <dbReference type="OMA" id="HHPNKAD"/>
    <dbReference type="OrthoDB" id="803114at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00018"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008839">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate reductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016726">
        <property type="term" value="F:oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00102">
        <property type="entry name" value="DapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022663">
        <property type="entry name" value="DapB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000846">
        <property type="entry name" value="DapB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022664">
        <property type="entry name" value="DapB_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023940">
        <property type="entry name" value="DHDPR_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20836">
        <property type="entry name" value="PTHR20836"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05173">
        <property type="entry name" value="DapB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01113">
        <property type="entry name" value="DapB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000161">
        <property type="entry name" value="DHPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00036">
        <property type="entry name" value="dapB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01298">
        <property type="entry name" value="DAPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword id="KW-0457">Lysine biosynthesis</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000228352" description="4-hydroxy-tetrahydrodipicolinate reductase">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="97"/>
            <end position="99"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="121"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="164"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>(S)-2,3,4,5-tetrahydrodipicolinate</name>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="266" mass="28204" checksum="DC4B58F141CD2136" modified="2005-11-22" version="1">MVKIAVCGAAGRMGQRIIVAAKEAGCTVSGALERPGHELVGQDAGLIAGCGALGVAISDDLNAVVDGCDVLIDFTTPKVSLKNLEACALKKKAIVIGSTGFTPEERALAAELAKDIPAVLAPNMSVGVNVCFKILKDVAKTLGDDFDVEIVELHHNKKKDAPSGTAVRMGEVVAEALGRDYNKVANYHREGICGERTKEEIGMQTVRGGDIVGEHTVYFIGMGERIEISHRAMTRDMFSRGSVRAAQWVVGKAPGLYDMQDVLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZC7</accession>
    <name>Q39ZC7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">frx-4</name>
        <name evidence="7" type="ordered locus">Gmet_0148</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512733.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0148"/>
    <dbReference type="EnsemblBacteria" id="ABB30397">
        <property type="protein sequence ID" value="ABB30397"/>
        <property type="gene ID" value="Gmet_0148"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0148"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_4_7"/>
    <dbReference type="OMA" id="VEICPDV"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="62" mass="6808" checksum="5D2B0158693BD1C2" modified="2005-11-22" version="1">MARNVYVEKDVCISCGLCVETVPEVFRFDDDNLAEAYDPAGAAEEKIQEAIDACPVSCIHWG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZK3</accession>
    <name>MTNA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="1">M1Pi</shortName>
            <shortName evidence="1">MTR-1-P isomerase</shortName>
            <ecNumber evidence="1">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mtnA</name>
        <name type="ordered locus">Gmet_0072</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514196.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZK3"/>
    <dbReference type="SMR" id="Q39ZK3"/>
    <dbReference type="STRING" id="269799.Gmet_0072"/>
    <dbReference type="EnsemblBacteria" id="ABB30321">
        <property type="protein sequence ID" value="ABB30321"/>
        <property type="gene ID" value="Gmet_0072"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0072"/>
    <dbReference type="eggNOG" id="COG0182">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016218_1_2_7"/>
    <dbReference type="OMA" id="RLWVDET"/>
    <dbReference type="OrthoDB" id="1290468at2"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019284">
        <property type="term" value="P:L-methionine salvage from S-adenosylmethionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000357188" description="Methylthioribose-1-phosphate isomerase">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="46"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="346" mass="37228" checksum="7A2ECDF501653823" modified="2005-11-22" version="1">MSFRTIEWRDDKVIMIDQTRLPGEEVYCEYGDYKSVAEAIRGMIIRGAPAIGVAAAMGVALGAREIIADTHESFLRQLDNVCDVLARTRPTAVNLFWAIERMKRVAADNCGGSLDEVREVLKAEAIRIEEEDLALCKAIGRHGAGLIPEGATVLTHCNAGGLATAGYGTALGVIRAAHEAGKNIQVFADETRPWLQGARLTAWELMKDGIPVTLISDNMAGFFMKRGEITCCVVGADRIAANGDTANKIGTYSVAVLAKENNIPFYVAAPTSTLDLSLENGDQIPIEERHAREVTHLQGLPVAPEGIAVRNPAFDVTPARYIAGIITEKGVITGDYTAKLKALVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZM2</accession>
    <name>Q39ZM2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transglutaminase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514177.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0053"/>
    <dbReference type="DNASU" id="3738541"/>
    <dbReference type="EnsemblBacteria" id="ABB30302">
        <property type="protein sequence ID" value="ABB30302"/>
        <property type="gene ID" value="Gmet_0053"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0053"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040402_0_0_7"/>
    <dbReference type="OMA" id="LYHSWAE"/>
    <dbReference type="OrthoDB" id="670657at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TGc" evidence="1">
        <location>
            <begin position="384"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="484" mass="52217" checksum="1D157B8EB606BBBA" modified="2005-11-22" version="1">MRLIHLYSQSLGILIFVLVTALSVNAETKASTLLQKPPVGERWFGIFLGNERTGFAHQNITAKDGGYEITVEGSVKMVVMGFSREASSRERYIVGTDLSLRSFAVEQVIDGTPMGVTGEATPKGVRVVVNAGGERKEKLLTAKGPVFPPPVLNILPLMKGTAKGKRLQVQMLDVEAVKVKKVTVTVVGFEPLPDGARALHIRNDLFPLVDNDIWVDAAGNTIRESVRDGLVETVAEDEGRTRQFIASAALSRRDLIFDFSLVRVDPPLANATSLSRLVLEIDGVPATMPLIQGGGQTARRTGAGTVVFTVEPAKAGASPLDEPERKRFSEPADRLPADHPDIIARAREVVGEETAPLKQVERLVKWVATTVEDAVTDAPSPLDTLKSRKGNCQSHARLYATLARAAGIPTRFVSGLVYLEGRGFLYHSWAESYVKGGWLQVDPTFGQVPVDATHVKLVEGEGPDDLAAIAGVVGKIKARVIEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>J7LWA1</accession>
    <name>J7LWA1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heptapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3658</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3658"/>
    <dbReference type="EnsemblBacteria" id="AFR42815">
        <property type="protein sequence ID" value="AFR42815"/>
        <property type="gene ID" value="Gmet_3658"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3658"/>
    <dbReference type="eggNOG" id="ENOG50338NA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158530_0_0_7"/>
    <dbReference type="OMA" id="VFFSEDC"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="79" mass="8954" checksum="7985D519E3F4B2E8" modified="2012-10-31" version="1">MRNSSSITLVFFSEDCQSKLDLVVEGQQMIVEKVDRLGTRMDRLDTKVDTSDVKVDVVFADLCVHRADTAVHHGVYRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYF5</accession>
    <name>J7LYF5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1563</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1563"/>
    <dbReference type="EnsemblBacteria" id="AFR42823">
        <property type="protein sequence ID" value="AFR42823"/>
        <property type="gene ID" value="Gmet_1563"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1563"/>
    <dbReference type="eggNOG" id="ENOG502ZMVA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1813028_0_0_7"/>
    <dbReference type="OMA" id="FHSSARE"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025737">
        <property type="entry name" value="Phenol_MetA_deg_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13557">
        <property type="entry name" value="Phenol_MetA_deg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003795601" evidence="1">
        <location>
            <begin position="34"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="263" mass="29282" checksum="30EDA8FC6210592A" modified="2012-10-31" version="1">MGQQRTTPSNRLKMKALAFILALAVLAPATAWAGPPFITDDPETVEYQHGEFYIASQYANNKDSKEGTAPHFEFNYGIIPDVQLHLLVPLAFVHPNGGPTMYGFGDTEVGVKYRFLHETDSVPQVGTFPIVHLPTGDSDRAVGGHVPVFLPIWLQKSRGPWTTYGGGGYWINPGEGNKNFWQLSWLGQREITKSLTLGAEIFYFGKDTDDGRDRTGYNIGWIFNLSEDHHILFSAGSDIAGNNRFSAYLGYQYTFGPREAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYJ3</accession>
    <name>J7LYJ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_A3642</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="AFR42862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514726.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3642"/>
    <dbReference type="EnsemblBacteria" id="AFR42862">
        <property type="protein sequence ID" value="AFR42862"/>
        <property type="gene ID" value="Gmet_A3642"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3642"/>
    <dbReference type="HOGENOM" id="CLU_2769999_0_0_7"/>
    <dbReference type="OrthoDB" id="1855549at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="69" mass="8065" checksum="A555022168A566B1" modified="2012-10-31" version="1">MSKTPESRTDWPRIEAMKDEEIDLTDSPELDADFIREAIPWGERAKKALDNGFLTEEEGKAWLREKLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>J7M074</accession>
    <name>J7M074_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFR42792">
        <property type="protein sequence ID" value="AFR42792"/>
        <property type="gene ID" value="Gmet_3579"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3579"/>
    <dbReference type="HOGENOM" id="CLU_185598_3_0_7"/>
    <dbReference type="OMA" id="MAKPNYQ"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="50" mass="5990" checksum="DDDD94593DABB7B0" modified="2012-10-31" version="1">MAKPNFQFQKRQKELERKKKNDEKLQRKLARKDSLPEEVSGQSTEEEEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PV7</accession>
    <name>Q39PV7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional protein PutA</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Proline dehydrogenase</fullName>
                <ecNumber evidence="3">1.5.5.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Proline oxidase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="3">P5C dehydrogenase</shortName>
                <ecNumber evidence="3">1.2.1.88</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="10" type="primary">putA</name>
        <name evidence="10" type="ordered locus">Gmet_3512</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Oxidizes proline to glutamate for use as a carbon and nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>H2O + L-glutamate 5-semialdehyde + NAD(+) = 2 H(+) + L-glutamate + NADH</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a quinone + L-proline = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the proline dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="3"/>
    <dbReference type="EC" id="1.2.1.88" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513668.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3512"/>
    <dbReference type="EnsemblBacteria" id="ABB33717">
        <property type="protein sequence ID" value="ABB33717"/>
        <property type="gene ID" value="Gmet_3512"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3512"/>
    <dbReference type="eggNOG" id="COG0506">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005682_2_1_7"/>
    <dbReference type="OMA" id="PPWNFPV"/>
    <dbReference type="OrthoDB" id="14333at2"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00373"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:1-pyrroline-5-carboxylate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006561">
        <property type="term" value="P:proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:proline catabolic process to glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07124">
        <property type="entry name" value="ALDH_PutA-P5CDH-RocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025703">
        <property type="entry name" value="Bifunct_PutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041514">
        <property type="entry name" value="PutA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005932">
        <property type="entry name" value="RocA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18083">
        <property type="entry name" value="PutA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000197">
        <property type="entry name" value="Bifunct_PutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01237">
        <property type="entry name" value="D1pyr5carbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PutA_N" evidence="9">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Pro_dh" evidence="8">
        <location>
            <begin position="129"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="domain" description="Aldedh" evidence="7">
        <location>
            <begin position="525"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="759"/>
        </location>
    </feature>
    <feature type="active site" evidence="4 5">
        <location>
            <position position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000197-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111299" checksum="9853F2448D7CBA4A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PX9</accession>
    <name>Q39PX9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aerobic-type carbon monoxide dehydrogenase, small subunit-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513647.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3490"/>
    <dbReference type="EnsemblBacteria" id="ABB33695">
        <property type="protein sequence ID" value="ABB33695"/>
        <property type="gene ID" value="Gmet_3490"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3490"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_0_7"/>
    <dbReference type="OMA" id="YPRIHKA"/>
    <dbReference type="OrthoDB" id="1819473at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="153" mass="16693" checksum="F5EB4629B63BAFF9" modified="2005-11-22" version="1">MKRITFKVNGVTHSFAGEPEMPLLWYLRDELHLTGTKYGCGKGLCGACTVQINGEATRSCITTMKSVAGKKIVTIEGLSARGDHPLQKAWQELNVPQCGYCQSGQIMQAAALLKGKPHPTDQEIDEAMGGNICRCGTYERIRQGIKRAAEVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q11</accession>
    <name>Q39Q11_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">tRNA (5-carboxymethylaminomethyl-2-thio-U34) synthesis sulfur carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tusA-2</name>
        <name evidence="3" type="ordered locus">Gmet_3454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513905.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3454"/>
    <dbReference type="EnsemblBacteria" id="ABB33663">
        <property type="protein sequence ID" value="ABB33663"/>
        <property type="gene ID" value="Gmet_3454"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3454"/>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2522818_0_0_7"/>
    <dbReference type="OMA" id="KEMNGHR"/>
    <dbReference type="OrthoDB" id="2042068at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="9"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="84" mass="9097" checksum="405EE2A7F0D659CB" modified="2005-11-22" version="1">MTSAAVDTIEYDIRGQICPSTLLIALREINSHAAALRKGEVALLFLTTNRDSTHTIPESAQNMGFCAVVAPRDGYYAIRVSGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q15</accession>
    <name>Q39Q15_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix-turn-helix transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513902.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3450"/>
    <dbReference type="EnsemblBacteria" id="ABB33659">
        <property type="protein sequence ID" value="ABB33659"/>
        <property type="gene ID" value="Gmet_3450"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3450"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_27_2_7"/>
    <dbReference type="OMA" id="TMSTPGN"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="16"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="151" mass="16585" checksum="4E678823E62557AD" modified="2005-11-22" version="1">MKHANNYTAYRALNSYTKLMRAAESVTSRTSRPMAAAGLTISQFGVLEALLHKGPLCQRDIAAKILKSTGNITMVIDNLEKQGLVRRERDMEDRRYLTVHLTEKGTILINKVFADVEASIVAEMSTLSADEQEQLGSLCKKLGLKGGTSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q16</accession>
    <name>Q39Q16_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic protein YceI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513901.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3449"/>
    <dbReference type="EnsemblBacteria" id="ABB33658">
        <property type="protein sequence ID" value="ABB33658"/>
        <property type="gene ID" value="Gmet_3449"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3449"/>
    <dbReference type="eggNOG" id="COG2353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071003_3_0_7"/>
    <dbReference type="OMA" id="GNYRAGF"/>
    <dbReference type="OrthoDB" id="1767227at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007372">
        <property type="entry name" value="Lipid/polyisoprenoid-bd_YceI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036761">
        <property type="entry name" value="TTHA0802/YceI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04264">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00867">
        <property type="entry name" value="YceI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101874">
        <property type="entry name" value="SSF101874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223131" evidence="1">
        <location>
            <begin position="23"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="YceI" evidence="2">
        <location>
            <begin position="24"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="196" mass="21379" checksum="DF93594CB51DE2E5" modified="2005-11-22" version="1">MKRIIASIATIAALSLPAFAFASTWTIDPDHSNVGFKVRHLMVSNVKGNFDKHSGTVEINDKDITKSKVNVSIDTASINTNVQKRDEHLRSADFFDVAKYPTMTFVSKKVAKNGKDKLKVTGDLTLHGVTKQVVLNVEGPTKESKDPWGNIRKGATAATKINRKDFGLVWNAALETGGVAVGDEIAITLEIEMIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q36</accession>
    <name>Q39Q36_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heterodisulfide oxidoreductase, FAD-binding and iron-sulfur cluster-binding subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hdrA</name>
        <name evidence="8" type="ordered locus">Gmet_3426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HdrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514233.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3426"/>
    <dbReference type="EnsemblBacteria" id="ABB33638">
        <property type="protein sequence ID" value="ABB33638"/>
        <property type="gene ID" value="Gmet_3426"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3426"/>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020302_0_0_7"/>
    <dbReference type="OMA" id="TAKHAML"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="234"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="282"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="585"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="624"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="665" mass="72167" checksum="9FA161B4532BDBFC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q84</accession>
    <name>Q39Q84_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Outer-membrane lipoprotein LolB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_3378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LolB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512604.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3378"/>
    <dbReference type="EnsemblBacteria" id="ABB33590">
        <property type="protein sequence ID" value="ABB33590"/>
        <property type="gene ID" value="Gmet_3378"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3378"/>
    <dbReference type="eggNOG" id="COG3017">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1188593_0_0_7"/>
    <dbReference type="OMA" id="ENDRFTC"/>
    <dbReference type="OrthoDB" id="1461803at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004565">
        <property type="entry name" value="OM_lipoprot_LolB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03550">
        <property type="entry name" value="LolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="10 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="247" mass="26426" checksum="0F0D0914FEF52F1E" modified="2005-11-22" version="1">MPVTDWTPHRRLPVAYGFLFLLALLILTTLGCATAPKPREPFIPGATVETLASGISLSVTSLEGSTGGTGYLLYRRPDSFHVVMLTPFGTTALEFFARDDRVTVLVPSKGIAYVGSFGDLPAKGGLQGWRMMRWVVEGDPLFAPGTTGTVERTDAEGRTTVARYDGEGLLQGKTSGGSEAVYRDYQSVGGVPFPATIELTDRQGVQVKISFDEPEVNAPVDDGALTPKLEGVTILPLARLAEAYSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q98</accession>
    <name>Q39Q98_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretion system protein GspD, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">gspD</name>
        <name evidence="9" type="ordered locus">Gmet_3364</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial secretin family. GSP D subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512590.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3364"/>
    <dbReference type="EnsemblBacteria" id="ABB33576">
        <property type="protein sequence ID" value="ABB33576"/>
        <property type="gene ID" value="Gmet_3364"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3364"/>
    <dbReference type="eggNOG" id="COG1450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006756_1_1_7"/>
    <dbReference type="OMA" id="YAVVEMD"/>
    <dbReference type="OrthoDB" id="881521at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013356">
        <property type="entry name" value="T2SS_GspD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02517">
        <property type="entry name" value="type_II_gspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223141" evidence="7">
        <location>
            <begin position="27"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="8">
        <location>
            <begin position="193"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Secretin_N" evidence="8">
        <location>
            <begin position="279"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="636" mass="67781" checksum="72ABDC7CB175BCB8" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QA7</accession>
    <name>NUOA2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit A 2</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit A 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit A 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NUO1 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoA2</name>
        <name type="ordered locus">Gmet_3355</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512581.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QA7"/>
    <dbReference type="SMR" id="Q39QA7"/>
    <dbReference type="STRING" id="269799.Gmet_3355"/>
    <dbReference type="EnsemblBacteria" id="ABB33567">
        <property type="protein sequence ID" value="ABB33567"/>
        <property type="gene ID" value="Gmet_3355"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3355"/>
    <dbReference type="eggNOG" id="COG0838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119549_3_1_7"/>
    <dbReference type="OMA" id="RFPVKYY"/>
    <dbReference type="OrthoDB" id="1748431at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000362692" description="NADH-quinone oxidoreductase subunit A 2">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <sequence length="118" mass="13316" checksum="6192FD0FAF14F785" modified="2005-11-22" version="1">MLGAYLPILVLVAIAVIFGLCSLVFSSLIGQKKPSVVKLAPYECGCEPVGSARERFSVKFYIIAMLFILFDIEAVFLYPWSVLFKRLGMFGVMEMGVFIVILFVGYIYVWKKGALEWE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-12-15" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QB7</accession>
    <name>NUOK2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit K 2</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit K 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit K 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoK2</name>
        <name type="ordered locus">Gmet_3345</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512571.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QB7"/>
    <dbReference type="SMR" id="Q39QB7"/>
    <dbReference type="STRING" id="269799.Gmet_3345"/>
    <dbReference type="EnsemblBacteria" id="ABB33557">
        <property type="protein sequence ID" value="ABB33557"/>
        <property type="gene ID" value="Gmet_3345"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3345"/>
    <dbReference type="eggNOG" id="COG0713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144724_0_0_7"/>
    <dbReference type="OMA" id="NFVAFSY"/>
    <dbReference type="OrthoDB" id="2081663at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000390077" description="NADH-quinone oxidoreductase subunit K 2">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <sequence length="100" mass="11068" checksum="02645B50AE35593C" modified="2005-11-22" version="1">MVSLHSYLILSAILFSIGTIGVLIRRNAIVIFMCVEMMLNSVNLTFIALSKHLGNVDGQIFVFFVMTVAAAEAAVGLALMIAFYKNRESIDVEDIKLMRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QE0</accession>
    <name>Q39QE0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyl viologen-reducing hydrogenase-associated ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mvhF</name>
        <name evidence="5" type="ordered locus">Gmet_3321</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512545.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3321"/>
    <dbReference type="EnsemblBacteria" id="ABB33534">
        <property type="protein sequence ID" value="ABB33534"/>
        <property type="gene ID" value="Gmet_3321"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3321"/>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_5_5_7"/>
    <dbReference type="OMA" id="CELCIDI"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="83" mass="9639" checksum="23D37B801BB1B388" modified="2005-11-22" version="1">MVEIKLHEEACRGCRMCVDICPTKVFAFDEEKRLCAVEHRDDCIACLSCAYLCPSGALRHEDYHVVKNFYRDLAFCAKMEKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QI3</accession>
    <name>Q39QI3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RNA polymerase-binding transcription factor DksA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dksA</name>
        <name evidence="10" type="ordered locus">Gmet_3278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Interacts directly with the RNA polymerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DksA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512716.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3278"/>
    <dbReference type="EnsemblBacteria" id="ABB33491">
        <property type="protein sequence ID" value="ABB33491"/>
        <property type="gene ID" value="Gmet_3278"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3278"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_2_1_7"/>
    <dbReference type="OMA" id="KKGEEYM"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00926">
        <property type="entry name" value="DksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012784">
        <property type="entry name" value="DksA_RNA_pol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020460">
        <property type="entry name" value="Znf_C4-type_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00618">
        <property type="entry name" value="DKSAZNFINGER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02420">
        <property type="entry name" value="dksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="9">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="118" mass="13783" checksum="05884F2B20614931" modified="2005-11-22" version="1">MDKEKLEYFRSILNDEIRSLQEEAGKTVSEMTVDSTSFPDPTDRATQESDRNFELRIRDRERKLINKIREALERIEDGSFGTCEVCGEDISEARLKARPVTTLCIDCKMEQERKEKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QM4</accession>
    <name>Q39QM4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YgdL family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512676.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3237"/>
    <dbReference type="EnsemblBacteria" id="ABB33450">
        <property type="protein sequence ID" value="ABB33450"/>
        <property type="gene ID" value="Gmet_3237"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3237"/>
    <dbReference type="eggNOG" id="COG1179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_4_1_7"/>
    <dbReference type="OMA" id="DMDDICV"/>
    <dbReference type="OrthoDB" id="1543144at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43267">
        <property type="entry name" value="PTHR43267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="ThiF" evidence="2">
        <location>
            <begin position="13"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="255" mass="28053" checksum="24521DD9483117B8" modified="2005-11-22" version="1">MSPLHRFSRTEILIGPEKLQRLRESTVAIFGLGGVGSFAAEALCRAGVGRLVLVDFDDICLTNVNRQLHAMDGTVGKAKVQVMAERLRLINPDADIVPHKDFYEAGNSDFLLSGGYNYVVDAIDHITSKLHLIRSCRERELRIISSMGAANKLDPTKIRVADISKTSVCGLARVVRKQLRRQGIKSGVTVVYSTEEPREQAIADAGCRSNCICPNKEEQRFSCEHRRNILGSISFIPSIFGLTMAGVVVNDLAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QV3</accession>
    <name>Q39QV3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_3158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366154.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3158"/>
    <dbReference type="EnsemblBacteria" id="ABB33371">
        <property type="protein sequence ID" value="ABB33371"/>
        <property type="gene ID" value="Gmet_3158"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3158"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="IGEHPKM"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="143"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="462" mass="51212" checksum="B3C469E9D91CF5A8" modified="2005-11-22" version="1">MTGTILIVDDERAQREIIQTILEGEGYRVAAAPGGREALEQLETSEFDVILTDLKMQGMSGMELLERVLEADPLQCAIMMTAHGTVDSAVEAMKKGAFDYLEKPLERDNLLLTLRRAFERVNLLRENRVLQKRLKETSSIPNIIGEHPKMREVFRIVTKIAPTASTVLIYGESGTGKELVAKAIHDGSPRKDKPFFAINCAAIPESLMESELFGHEKGAFTGASSRELGIFEAATGGTVFLDEIGEMSVAMQAKLLRAIQSKEIRRVGGKVNIPVDVRIISATNRDLEAEIKRGGFREDLFYRLNVIRITLPPLRERGSDIAALADFFVKKCSAQAGVTVRGIAKPALKLIMDYSWPGNVRQLESVIERGALMAESDLIQPEDLPAEITEGLSRAGWLPFELPPDGIQFDELERNLIIKAMERADWVIAKAAPLLGMSYKTLQYRLEKFEIGRDRGTGNGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QV4</accession>
    <name>Q39QV4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_3157</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513873.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3157"/>
    <dbReference type="EnsemblBacteria" id="ABB33370">
        <property type="protein sequence ID" value="ABB33370"/>
        <property type="gene ID" value="Gmet_3157"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3157"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_29_7"/>
    <dbReference type="OMA" id="RNPLNYI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="184"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="256"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="484" mass="53968" checksum="FE9FE72C39EF6E14" modified="2005-11-22" version="1">MTLNTRLVMIMLTLLVIAILTLFFLNQYSQNEMVQEIQESSTMVTKALQMSIEDLTSEYEPDRGRLTEYLKEAKVKGVKEINIFSNEGEIIDSSNPAKIGKKREIKKLEKGLKVSPGTKTDAGSSRAYDLVVPVIVGDEQLGYVQINLLLDNIRTIQHENFVNRVVATSLVFLLGISLTIFLAKRYTAPINHLADGVRRVAVGDLSVTFPVTTGDEIGELAKNFNEMVEKLREREILEKRLYEAEHLSRVGQLASGIAHEIRNPLNYISLAIDHLKSEFTAACPDKTERVVPVADKIKEEVRRANYMVVNFMNFGRPLKLRITEISYRELIEKALPLLEEKLAEQRVTVRTAIPTDLPAMRVDGEMLRNCLFNFVTNAAQAMPDGGTVTLGATFDREQNRFLLTFSDEGCGIREEDLAKVFQPWYTTREAGIGLGLAITERIVREHGGEIRVASSAGKGTTFTVLLPGGEKPGPGTRDRGPGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QW8</accession>
    <name>Q39QW8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Resolvase-like serine recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513858.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3143"/>
    <dbReference type="DNASU" id="3740917"/>
    <dbReference type="EnsemblBacteria" id="ABB33356">
        <property type="protein sequence ID" value="ABB33356"/>
        <property type="gene ID" value="Gmet_3143"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3143"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030020_2_0_7"/>
    <dbReference type="OMA" id="LCISYIR"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038109">
        <property type="entry name" value="DNA_bind_recomb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025827">
        <property type="entry name" value="Zn_ribbon_recom_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13408">
        <property type="entry name" value="Zn_ribbon_recom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51737">
        <property type="entry name" value="RECOMBINASE_DNA_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="2">
        <location>
            <begin position="5"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Recombinase" evidence="3">
        <location>
            <begin position="176"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="417"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="622" mass="72198" checksum="5128EABC3A6D1A8D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R03</accession>
    <name>Q39R03_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3107</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514282.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3107"/>
    <dbReference type="EnsemblBacteria" id="ABB33321">
        <property type="protein sequence ID" value="ABB33321"/>
        <property type="gene ID" value="Gmet_3107"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3107"/>
    <dbReference type="eggNOG" id="COG3334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127580_0_0_7"/>
    <dbReference type="OMA" id="KVQSANY"/>
    <dbReference type="OrthoDB" id="1999230at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223161" evidence="2">
        <location>
            <begin position="32"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="182" mass="19594" checksum="28798CA643B38B11" modified="2005-11-22" version="1">MRKKAFIPIVAVAGFFLLLAPPICSPPSVEAQPSGGGSTRPAVAAPVYPTAGTKNGVSEAASLELKKQQLAAKEAALAVKEQELKALAATLEARVKELEAAKAGLDRSLDARKKVQSANYQKLLKVYKGLKPQEAVKLLDGLSENEALELLSEMDQKRATKLLPLIKKERALKWTRQNLAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R14</accession>
    <name>Q39R14_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Flagellar biosynthetic protein FliQ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 10" type="primary">fliQ</name>
        <name evidence="10" type="ordered locus">Gmet_3096</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Role in flagellar biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FliQ/MopD/SpaQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514550.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3096"/>
    <dbReference type="EnsemblBacteria" id="ABB33310">
        <property type="protein sequence ID" value="ABB33310"/>
        <property type="gene ID" value="Gmet_3096"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3096"/>
    <dbReference type="eggNOG" id="COG1987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164516_0_1_7"/>
    <dbReference type="OMA" id="TMPWMLN"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002191">
        <property type="entry name" value="Bac_export_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006305">
        <property type="entry name" value="FliQ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34040">
        <property type="entry name" value="PTHR34040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01313">
        <property type="entry name" value="Bac_export_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004669">
        <property type="entry name" value="FliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00952">
        <property type="entry name" value="TYPE3IMQPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01402">
        <property type="entry name" value="fliQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="4 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="89" mass="9989" checksum="A7E26971936D668C" modified="2005-11-22" version="1">MSPDLVVQLARRSFEVTLLLSAPLLISGLVVGLLISIFQAVTSIQEATLAFAPKIIIVMVAMVIFFPWMMSYMSDFTRELYALIPNMRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R85</accession>
    <name>Q39R85_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leucyl aminopeptidase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514338.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3024"/>
    <dbReference type="EnsemblBacteria" id="ABB33239">
        <property type="protein sequence ID" value="ABB33239"/>
        <property type="gene ID" value="Gmet_3024"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3024"/>
    <dbReference type="eggNOG" id="COG2309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062630_0_0_7"/>
    <dbReference type="OMA" id="HEDYVFY"/>
    <dbReference type="OrthoDB" id="689314at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000787">
        <property type="entry name" value="Peptidase_M29"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02073">
        <property type="entry name" value="Peptidase_M29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="374" mass="40882" checksum="C35635C21938493E" modified="2005-11-22" version="1">MYQDAFRSLFEINMGIRSGERVLVFSDTIRIDEAPIPSERNRRERLLQVAEEAARFAETTYGRTDFVSFPATAASGAEPPETLWRSAFGNGIVDTLAAEGILPRLLAKEATADDVERSRELILASRRDVVDVVVALANNSTSHTRFRSLVNAAGGRFASLPHFDPEMFFTSMQVDWHALAERTKQLAAAVNEATEILIETPNGTRMRIGKAGRQAEGDDGLLTAPGSFGNLPAGEVYLAPLEGTSEGVMVLEYGPTRKLSSSVELIVRNGIVTDIRGDEPHREWLERRFAENGKNRNIAELGIGTNDRATRPDNILEAEKILGTIHIALGDNSGFGGTVQTPFHEDYVFYRPTLTAVAANGSPTVLLRDGTLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R87</accession>
    <name>Q39R87_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="16">NADPH oxidoreductase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="primary">sfrA</name>
        <name evidence="16" type="ordered locus">Gmet_3022</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514336.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3022"/>
    <dbReference type="EnsemblBacteria" id="ABB33237">
        <property type="protein sequence ID" value="ABB33237"/>
        <property type="gene ID" value="Gmet_3022"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3022"/>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_4_0_7"/>
    <dbReference type="OMA" id="HKNVGPL"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="15">
        <location>
            <begin position="78"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="13">
        <location>
            <begin position="172"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="14">
        <location>
            <begin position="215"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB33237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="831" mass="87782" checksum="A649DBF61693DCE4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RA2</accession>
    <name>Q39RA2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">O-acetyl-ADP-ribose deacetylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ymdB</name>
        <name evidence="2" type="ordered locus">Gmet_3007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514319.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3007"/>
    <dbReference type="EnsemblBacteria" id="ABB33222">
        <property type="protein sequence ID" value="ABB33222"/>
        <property type="gene ID" value="Gmet_3007"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3007"/>
    <dbReference type="eggNOG" id="COG2110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046550_5_1_7"/>
    <dbReference type="OMA" id="HYGKGLP"/>
    <dbReference type="OrthoDB" id="1812319at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Macro" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="173" mass="18196" checksum="544070A767529FBE" modified="2005-11-22" version="1">MREKIEIIPGDITKLAVDTIVNAANNSLLGGGGVDGAIHRAAGPELLAECRTLNGCATGDAKITKGYRLPAKHVIHTVGPVWHGGAKGEQELLRSCYRRCFEVAHGAGLTSIAFPAISCGVYGYPLTEACAIAVEETKTALERYPELARVIFTPFGAEAEAAYRAALAKVFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RE3</accession>
    <name>Q39RE3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512899.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2966"/>
    <dbReference type="EnsemblBacteria" id="ABB33181">
        <property type="protein sequence ID" value="ABB33181"/>
        <property type="gene ID" value="Gmet_2966"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2966"/>
    <dbReference type="eggNOG" id="ENOG502ZWB9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_930174_0_0_7"/>
    <dbReference type="OrthoDB" id="1405623at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="309" mass="35720" checksum="FF6301AA47A5D187" modified="2005-11-22" version="1">MKKQTEINPVEFAKWFRELPEKEKRKGSQIEALRAEEDWENFSELFRKGVCSICNKPLKTFSVSNPCLHWLLKPKGFKKNHFKYLMENFRYFRISAYARWVAAIDGPIRNINDLKDEHSGNKIFDFTARYKHITWSYSCSDTDFKGHSTSRNSDFPHYHMQMYVNKMPFIKYNDFHIPFHNEDLCDLELLINNSDIVKHSYGRGDGMEAIFSNEDALNFIIDKSTPTTDAEAAFHMSTIVMAPEGGTISGDEIHEAFEEAKATGRTMASVLRERLKDANIRTIVSPGEGVPEAMPRSGRNKDRARDDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RH0</accession>
    <name>Q39RH0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain iron-sulfur cluster-binding oxidoreductase, TIGR01212 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yhcC-2</name>
        <name evidence="8" type="ordered locus">Gmet_2936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512872.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2936"/>
    <dbReference type="EnsemblBacteria" id="ABB33154">
        <property type="protein sequence ID" value="ABB33154"/>
        <property type="gene ID" value="Gmet_2936"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2936"/>
    <dbReference type="eggNOG" id="COG1242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060920_0_0_7"/>
    <dbReference type="OMA" id="TSWWKIK"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005911">
        <property type="entry name" value="YhcC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF1">
        <property type="entry name" value="PTHR11135:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01091">
        <property type="entry name" value="uncharacterized_CHP01210-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01212">
        <property type="entry name" value="TIGR01212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="22"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="319" mass="35769" checksum="28DFFD56876CD573" modified="2005-11-22" version="1">MPDLLINPDLRFNSYGTYLRRRFGCRVSKVNVDGGFTCPNRDGTRGTGGCIYCDNASFSPGGTVAEIPIEIQMAEGMAYHRRRLGSEKFIVYFQKFTNTYAPVERLRDLYARALAHPDVIGISVGTRPDSLSDEALDLLADLAKRHYVCIELGLQSMDDKILQQIGRGHTLTEYLEAVARIEGRGIELCTHLIYGFPGETRDGFLRTADMMAGLPVNSVKIHQLHAVKGTRLAELYHQGDFVPITHQEYVATACDFLEILPPRIAIQRLYGSAPLTIRVAPTWNLKNNQMWFSIVNELKRRGTWQGCRLTDSCLKAGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RI0</accession>
    <name>Q39RI0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512862.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2926"/>
    <dbReference type="EnsemblBacteria" id="ABB33144">
        <property type="protein sequence ID" value="ABB33144"/>
        <property type="gene ID" value="Gmet_2926"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2926"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1903696_0_0_7"/>
    <dbReference type="OMA" id="AEMFIES"/>
    <dbReference type="OrthoDB" id="1613954at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="14473" checksum="666E7EC37A1B8BC0" modified="2005-11-22" version="1">MLGLLIADNDTVARKELADLFIEAGYNVTVTNSAANALYGILKKTAQVVLIGSEFDNFKAGDLIPLLKQCDRNVTIILVSDEDSLPVMRKLRKDGIFYHALRPVKPEDKEEIRQAVRCAFENLLSARPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RI6</accession>
    <name>Q39RI6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4105 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33138.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2920"/>
    <dbReference type="EnsemblBacteria" id="ABB33138">
        <property type="protein sequence ID" value="ABB33138"/>
        <property type="gene ID" value="Gmet_2920"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2920"/>
    <dbReference type="eggNOG" id="ENOG502Z92U">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025316_1_0_7"/>
    <dbReference type="OMA" id="NRDLWEY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025178">
        <property type="entry name" value="DUF4105"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13387">
        <property type="entry name" value="DUF4105"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4105" evidence="1">
        <location>
            <begin position="133"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33138.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="636" mass="71185" checksum="C30D3E7441A745B9" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RI7</accession>
    <name>Q39RI7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NrdH-like redox lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512855.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2919"/>
    <dbReference type="EnsemblBacteria" id="ABB33137">
        <property type="protein sequence ID" value="ABB33137"/>
        <property type="gene ID" value="Gmet_2919"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2919"/>
    <dbReference type="eggNOG" id="COG0695">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1893197_0_0_7"/>
    <dbReference type="OMA" id="PYCDEVE"/>
    <dbReference type="OrthoDB" id="2045232at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097573">
        <property type="term" value="F:glutathione oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="134" mass="14508" checksum="133CF876DD692B13" modified="2005-11-22" version="1">MILRIIVALLTVVLAVALLAGCTPARPAVPPVPSGAAAENRHEVVVYVRTGCSFCQEAREFLAARGVPVRERNVAADRSALVEMLDIHVRRFPDEEPLVPLIVIGDRVVRGFDRQEVEAALAEVERTSTAGSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RJ7</accession>
    <name>Q39RJ7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Thiamine-phosphate synthase</fullName>
            <shortName evidence="12">TP synthase</shortName>
            <shortName evidence="12">TPS</shortName>
            <ecNumber evidence="12">2.5.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Thiamine-phosphate pyrophosphorylase</fullName>
            <shortName evidence="12">TMP pyrophosphorylase</shortName>
            <shortName evidence="12">TMP-PPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="primary">thiD</name>
        <name evidence="12 15" type="synonym">thiE</name>
        <name evidence="15" type="ordered locus">Gmet_2909</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 12">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 12">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = CO2 + diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 12">
            <text>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 4-methyl-5-(2-phosphooxyethyl)-thiazole + H(+) = diphosphate + thiamine phosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ATP = 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + ADP</text>
            <dbReference type="Rhea" id="RHEA:19893"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.7"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16892"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7 12">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.3" evidence="12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512845.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2909"/>
    <dbReference type="EnsemblBacteria" id="ABB33127">
        <property type="protein sequence ID" value="ABB33127"/>
        <property type="gene ID" value="Gmet_2909"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2909"/>
    <dbReference type="eggNOG" id="COG0351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020520_5_1_7"/>
    <dbReference type="OMA" id="HSGKERR"/>
    <dbReference type="OrthoDB" id="461201at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00138"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045029">
        <property type="entry name" value="HMP/HMP-P_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PTHR20858"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="SSF51391"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00097">
        <property type="entry name" value="HMP-P_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TMP-TENI" evidence="13">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Phos_pyr_kin" evidence="14">
        <location>
            <begin position="235"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="HMP-PP binding" evidence="12">
        <location>
            <begin position="50"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="12">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="THZ-P binding" evidence="12">
        <location>
            <begin position="197"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine</name>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB33127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="497" mass="52391" checksum="D89049C6DDF85AD1" modified="2005-11-22" version="1">MGSNGHNLRLVVNRDKQDSPIRGVYLVTDHGDRLAERVEAAIDGGVRIVQYRNKGKDRAQRYAVGEELRDLCSRRGVIFIVNDDLDLALQLKADGIHLGQEDGDPRIARRELGPGRIIGVSTHTMEEALAAQAAGADYIGFGAMFPTNSKEIGHLAGPEGLAAIRSRIMIPIVAIGGISRDNGPRVVDAGADALAVISAVLAHPDPFLAATELGLLFNRRAPHPRGAVLTIAGSDSGGGAGIQADLKTATLLGSYGSSVITALTAQNTRGVSGIHGVPPSFVAEQLDAVLSDIPVDTVKTGMLFSAEIIATVADKLAEYRKRIVVVDPVMVAKGGAPLIDRGAVNVLKDRLMPRTYLLTPNIPEAERLTGLTIVDEEGMQEAARRLFRLGARNVLVKGGHLVAGDAVDILFDGSAFHRFTAPRILSKNTHGTGCTYAAAIATYLAQGEPLREAVGRAKEFVTAAIRLGQPLGRGHGPVNHLLAALEVGDQGPGTGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RR4</accession>
    <name>Q39RR4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein DUF2232, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514574.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2842"/>
    <dbReference type="EnsemblBacteria" id="ABB33060">
        <property type="protein sequence ID" value="ABB33060"/>
        <property type="gene ID" value="Gmet_2842"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2842"/>
    <dbReference type="eggNOG" id="COG4241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068641_1_0_7"/>
    <dbReference type="OMA" id="FDLWGDF"/>
    <dbReference type="OrthoDB" id="1112251at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018710">
        <property type="entry name" value="DUF2232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09991">
        <property type="entry name" value="DUF2232"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="315" mass="33924" checksum="D628C5982ED68211" modified="2005-11-22" version="1">MVTGDRGIILDIVKGVCLSVVIFIAYLQVPLLGMIAGVVAPLPVLYYQLKSGRWMVGAIAISAIALILILVGGMPVAVLYLLQAGLFSVALPHFLARGHSVSRALASAVLTVALVATISVAGYGIAAGIDLHHQVTIAIKTNLEQTLALYKAKGASGEDLQFLKEGLRQVGDIFGQIYPAMLLVSLAAVAGINLLILRRFREGLTVKLPVTPFSSFKNPEHLVWGLIAAGFALLIDNGVVQTVAFNVVVVAGFLYFLQGLAVVAHFFASYRVPAFFKIFFYVLLLLQAYLVLAVALLGLFDLWANFRRPRIHENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RU9</accession>
    <name>Q39RU9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2807</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514677.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2807"/>
    <dbReference type="EnsemblBacteria" id="ABB33025">
        <property type="protein sequence ID" value="ABB33025"/>
        <property type="gene ID" value="Gmet_2807"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2807"/>
    <dbReference type="eggNOG" id="COG1661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114051_1_0_7"/>
    <dbReference type="OMA" id="ACGREEN"/>
    <dbReference type="OrthoDB" id="1752865at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="144" mass="15729" checksum="1EDCB8723E54AC08" modified="2005-11-22" version="1">MNYQTGTPGRIVVARFDHGEDVLAGLEEIARREGLRAAAFHIVGALKGGRYVVGPEAEELPPVPVWRRLEESHEAVGFGTIFWEGDRPKVHFHGAYGKGDAVRVGCLREASEVFLVLEAIITEIRGVTAIRELDPASGMVLLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RV4</accession>
    <name>Q39RV4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33020.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514682.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2802"/>
    <dbReference type="EnsemblBacteria" id="ABB33020">
        <property type="protein sequence ID" value="ABB33020"/>
        <property type="gene ID" value="Gmet_2802"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2802"/>
    <dbReference type="eggNOG" id="ENOG50332QF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138548_0_0_7"/>
    <dbReference type="OMA" id="VVETRMN"/>
    <dbReference type="OrthoDB" id="1670533at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33020.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="120" mass="13729" checksum="A1FBA78A88C466B3" modified="2012-10-31" version="2">MNARVKLKPGQKGTKKLLAQYGDSLVCVRYRYDVEKRKQVKTVELIVSETDWTPPPPKYPESALVPLRVGVTEKALQEQVRVLGGRWDRAQQVWFVRYGCIAGTKLEKLIVVETRMNTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RX1</accession>
    <name>Q39RX1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511677.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2785"/>
    <dbReference type="EnsemblBacteria" id="ABB33003">
        <property type="protein sequence ID" value="ABB33003"/>
        <property type="gene ID" value="Gmet_2785"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2785"/>
    <dbReference type="eggNOG" id="COG2403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046378_0_0_7"/>
    <dbReference type="OMA" id="ECTIEER"/>
    <dbReference type="OrthoDB" id="414225at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="442" mass="48788" checksum="29DFD6EA5400E348" modified="2005-11-22" version="1">MKRKRIIIMGAAGRDFHNFNCSFRDNPVFRVVAFTAAQIPYISNRRYPAELAGKLYPRGIPIFPEEELGELIRRLRAEQVVFAYSDVSHERLMHIASRVLALGADFLLMGPDATMLRSRLPVVSVCAVRTGCGKSQVVRYFCDILRERGIRPVVVRHPMPYGDLAAQAVERLEGLADLDRFRCTIEEREEYEHLLDHGAIVYAGVDYRRILRRAEREARLIIWDGGNNDLPFFRPDLEMVVVDPLRPGHETSWYPGEVNLRRASVVVMNKVNAAEPAAIEAVATAVRSANPSALLVRTASVITVAEGERIRGKRVLVIEDGPTITHGSMPSGAGLAAARQHGAAEAVDPRPWAQGSLREVYGAWSHIGPVLPAMGYSPAQVADLARTIEAVPCDLVVAATPIDIARLTGTGKTVLRASYAIGEGEGEPLREAFESFLRTRQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S22</accession>
    <name>Q39S22_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FeMo cofactor biosynthesis protein NifB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Nitrogenase cofactor maturase NifB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Radical SAM assemblase NifB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Gmet_2734</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; Fe-Mo cofactor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the radical SAM superfamily. NifB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511726.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32952">
        <property type="protein sequence ID" value="ABB32952"/>
        <property type="gene ID" value="Gmet_2734"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2734"/>
    <dbReference type="eggNOG" id="COG0641">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_3_1_7"/>
    <dbReference type="OMA" id="PYKGTMK"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="UniPathway" id="UPA00782"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026322">
        <property type="entry name" value="Geopep_mat_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005980">
        <property type="entry name" value="Nase_CF_NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43787:SF3">
        <property type="entry name" value="PTHR43787:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04280">
        <property type="entry name" value="geopep_mat_rSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="80"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="446" mass="48725" checksum="C064632EB6924201" modified="2005-11-22" version="1">MILSRHVKVFPCTEQPGHLILFSCRTGAVLRVPAPLLEAARGGTLSPKPAETLSRHGFLAEDPGTEQREMLAWFDRINARRRRCSAVVVLTRACNLACPYCFEANQPSLRQMDGETADLFVSLVEREHLARGRRVSLNFYGGEALLRPDLIRRIAGPLRATGGDRFSFSLVTNGTLLTRTLVKDLLPLGLDGAKVTLDGPPQIHDRLRPFVSGEGSFAAIIANLREVCGLIGIAIGGNYTRDTWREFPQLLDILPVAGLTPERVRLVRFDPVIGREGVAGLPDFSEGCGGLTEPWLVEASLVLREEIVKRGYLTSKPAPAACMVEFDTDLVVDTDGAIYRCPAFIGRPAFVAGHLRNGAGSAGDAYGMDAWKQEECLDCAYLPLCFGGCRFMRLVETGAVDGVACQREYLDATLEAMVRRGEYPLTRPPGTLSHGERELHPSPCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S30</accession>
    <name>Q39S30_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Neutral zinc metallopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2726</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511734.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2726"/>
    <dbReference type="EnsemblBacteria" id="ABB32944">
        <property type="protein sequence ID" value="ABB32944"/>
        <property type="gene ID" value="Gmet_2726"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2726"/>
    <dbReference type="eggNOG" id="COG2321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059329_0_0_7"/>
    <dbReference type="OMA" id="QKRSQGY"/>
    <dbReference type="OrthoDB" id="1175086at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007343">
        <property type="entry name" value="Uncharacterised_pept_Zn_put"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30168">
        <property type="entry name" value="PTHR30168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04228">
        <property type="entry name" value="Zn_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="284" mass="31078" checksum="07BDDAD82C32E9BF" modified="2005-11-22" version="1">MRWSDGRRSDNVEDRRGMTVGRKAVGGGIGTIILALVAMYFGIDPSVVLQQGGSPLTAPTETRQAGKPPASDELAQFVSVVLADTEDTWHELFRKNGKTYQEPKLVLFTGAVESACGYAQAAMGPFYCPLDQKVYIDLSFYRDLKERFKAPGDFAQAYVIAHEVGHHVQSLLGISEKAHDLQQRSGKTQANQLSVRLELQADCLAGIWAHHADRSRQVLESGDVEEALQAATSIGDDRLQQQAQGYVVPESFTHGSSEQRVRWFKTGLDTGNFGACNTFGAQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S89</accession>
    <name>Q39S89_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Archaeal DEXX-box ATPase with DUF234</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511794.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2667"/>
    <dbReference type="DNASU" id="3740187"/>
    <dbReference type="EnsemblBacteria" id="ABB32885">
        <property type="protein sequence ID" value="ABB32885"/>
        <property type="gene ID" value="Gmet_2667"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2667"/>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041137_3_0_7"/>
    <dbReference type="OMA" id="YNEDKFH"/>
    <dbReference type="OrthoDB" id="801313at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011579">
        <property type="entry name" value="ATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004256">
        <property type="entry name" value="DUF234_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01637">
        <property type="entry name" value="ATPase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03008">
        <property type="entry name" value="DUF234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase_2" evidence="1">
        <location>
            <begin position="3"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="DUF234" evidence="2">
        <location>
            <begin position="324"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="478" mass="55074" checksum="E8509B7876B5F095" modified="2005-11-22" version="1">MRFYNREKELARLMEIATLSEESAHLAVITGRRRVGKTELIRKFAEGRDDFLYFFVSKKKPRVLLDEFRDLLAARVPLLASASFGSFDDFFRALFEITKERPLFIVFDEFQNFQQVDPAVFSTLQDLWDRNKGTIKGTIVCIGSVQTLMREIFEGAKEPLFGRVTARLYVEPLIPDVVATILADHQVDAVRHLPFFFTLFGGIPKYYFLLDRYRLFGKTPAEIIRKFFCETDALLQNEGKDLLVEEFGKNYHLYFSILQVIAGGENQMARIADKSGINVNSISKYLDELTSYYQVIERRLPVTATRQEQKTGRYYLKDPLLRFWFRYIYRNQSLIEIGDEEGLLGKIQADLSTFMGWSFEELIRAMLLKRNDGTVVPFGFTRIGGFWTKRGDVEIDIVALNEEDGAIFFGECKLSGSRFSVADARRLKEKAKAVPWRTGDRREHFVLFCMDDLESDAEQALAAEGVGVVRLRQLLSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SC2</accession>
    <name>Q39SC2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thiol reductant ABC exporter, ATP-binding protein CydC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cydC</name>
        <name evidence="10" type="ordered locus">Gmet_2633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511828.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2633"/>
    <dbReference type="EnsemblBacteria" id="ABB32852">
        <property type="protein sequence ID" value="ABB32852"/>
        <property type="gene ID" value="Gmet_2633"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2633"/>
    <dbReference type="eggNOG" id="COG4987">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_7"/>
    <dbReference type="OMA" id="VSHNATF"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034775">
        <property type="term" value="P:glutathione transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014223">
        <property type="entry name" value="ABC_CydC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02868">
        <property type="entry name" value="CydC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="338"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="371"/>
            <end position="378"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="547" mass="56653" checksum="9ABC97058F96BF56" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SC6</accession>
    <name>Q39SC6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sensor diguanylate cyclase/phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2629</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511832.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2629"/>
    <dbReference type="EnsemblBacteria" id="ABB32848">
        <property type="protein sequence ID" value="ABB32848"/>
        <property type="gene ID" value="Gmet_2629"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2629"/>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_50_7"/>
    <dbReference type="OMA" id="PNEREDA"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="259"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="330"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="416"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="558"/>
            <end position="811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="821" mass="92585" checksum="3F093A06C359DA6C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SD0</accession>
    <name>Q39SD0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2625</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2625"/>
    <dbReference type="EnsemblBacteria" id="ABB32844">
        <property type="protein sequence ID" value="ABB32844"/>
        <property type="gene ID" value="Gmet_2625"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2625"/>
    <dbReference type="HOGENOM" id="CLU_2584745_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="80" mass="8779" checksum="27C42DAB6C6CED88" modified="2005-11-22" version="1">MPSLASPCRSGMEPARPERFIGESIAPELPWASAQRGAAGETVSEGVVEEFPALPCLWLHFETPINRTPTMKTRTIIFPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SD6</accession>
    <name>Q39SD6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-6-phosphate 1-dehydrogenase</fullName>
            <shortName evidence="5">G6PD</shortName>
            <ecNumber evidence="5">1.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">zwf</name>
        <name evidence="9" type="ordered locus">Gmet_2619</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15841"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="1.1.1.49"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glucose-6-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.49" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366074.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2619"/>
    <dbReference type="EnsemblBacteria" id="ABB32838">
        <property type="protein sequence ID" value="ABB32838"/>
        <property type="gene ID" value="Gmet_2619"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2619"/>
    <dbReference type="eggNOG" id="COG0364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013524_5_0_7"/>
    <dbReference type="OMA" id="PDEGIQM"/>
    <dbReference type="OrthoDB" id="1153269at2"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00408"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004345">
        <property type="term" value="F:glucose-6-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00966">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001282">
        <property type="entry name" value="G6P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019796">
        <property type="entry name" value="G6P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022675">
        <property type="entry name" value="G6P_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022674">
        <property type="entry name" value="G6P_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23429">
        <property type="entry name" value="PTHR23429"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02781">
        <property type="entry name" value="G6PD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00479">
        <property type="entry name" value="G6PD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000110">
        <property type="entry name" value="G6PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00079">
        <property type="entry name" value="G6PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00871">
        <property type="entry name" value="zwf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00069">
        <property type="entry name" value="G6P_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="1 5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="2 5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G6PD_N" evidence="7">
        <location>
            <begin position="15"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="G6PD_C" evidence="8">
        <location>
            <begin position="199"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="95"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="512" mass="57479" checksum="51BBCB0EA5A8A53F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SP0</accession>
    <name>Q39SP0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEP motif-containing protein, putative exosortase substrate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514774.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2512"/>
    <dbReference type="EnsemblBacteria" id="ABB32734">
        <property type="protein sequence ID" value="ABB32734"/>
        <property type="gene ID" value="Gmet_2512"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2512"/>
    <dbReference type="HOGENOM" id="CLU_1439205_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223236" evidence="1">
        <location>
            <begin position="23"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="188" mass="19470" checksum="CCAD7D7E4DA0FAC1" modified="2005-11-22" version="1">MKRLIALLLLVAALAFAPHAEAFSLSLEPPSQTIAVGDTATFALRVTDLADPILFYTLDVLFDASVLAFQGAIFTNALGNPSDSMVDTSLVDTGLLGLVGTSATGSLTGDFDLAYLTFSGITAGTSDLIIGSNTFFGIDPNTGGDIPLNVDSLFDSRATVVNAVPEPGTLILLGAGLTGLAVWRRRHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T43</accession>
    <name>Q39T43_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">OmpH-like outer membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2356</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513264.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2356"/>
    <dbReference type="EnsemblBacteria" id="ABB32581">
        <property type="protein sequence ID" value="ABB32581"/>
        <property type="gene ID" value="Gmet_2356"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2356"/>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101388_3_0_7"/>
    <dbReference type="OMA" id="ERYNKEW"/>
    <dbReference type="OrthoDB" id="1854604at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223267" evidence="4">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="40"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="173" mass="19830" checksum="3576A6BEF8539C85" modified="2005-11-22" version="1">MKRFVTVASIVGSLVLASVAFGADGGKLGYIDMQKALNLSESGKEAKEQLAAKVKKYQDEINTKQEELKKLKDDLEKQSVLLSEAARSNKEKDYQQKLKEFQRFTKDAQDELQTKDEEFTKKIIEELEKVVQDYGRKNGYSFIFIRNEGMIYVDDKADVTDEILKLFNASRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T77</accession>
    <name>Q39T77_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF218 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2322</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513298.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2322"/>
    <dbReference type="EnsemblBacteria" id="ABB32547">
        <property type="protein sequence ID" value="ABB32547"/>
        <property type="gene ID" value="Gmet_2322"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2322"/>
    <dbReference type="eggNOG" id="COG1434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080658_0_0_7"/>
    <dbReference type="OMA" id="CCVDLDY"/>
    <dbReference type="OrthoDB" id="1879123at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06259">
        <property type="entry name" value="YdcF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003848">
        <property type="entry name" value="DUF218"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02698">
        <property type="entry name" value="DUF218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF218" evidence="1">
        <location>
            <begin position="41"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="200" mass="23243" checksum="440F0C5C0C450A6A" modified="2005-11-22" version="1">MALFFRGLFSLLVIFLVVATVLFVDFAYKTFSVRQRDIATDAIVVLAGGRGRVEEGIRLFRAKKGKYLFLIGVDPMVRKQELFQERKGESLADRVVLENASRNTLENALYGREIIDRKDIRSISLITSRYHMKRATLIFRSTLPRDIAIYPHPVDTINLKEAWWRDQGSFRLLFSEFYKYCLFRFFFLFASGELRPPAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T92</accession>
    <name>Q39T92_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Scaffold protein CheW associated with MCPs of class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheW40H-2</name>
        <name evidence="2" type="ordered locus">Gmet_2307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513313.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2307"/>
    <dbReference type="EnsemblBacteria" id="ABB32532">
        <property type="protein sequence ID" value="ABB32532"/>
        <property type="gene ID" value="Gmet_2307"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2307"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_1_7"/>
    <dbReference type="OMA" id="YAVDIMR"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="164" mass="18140" checksum="A2351B86609B4F51" modified="2005-11-22" version="1">MMETDIQEIQLACFRLGDANFAADIMRIKEILKPQHLTKLPRTPSFVEGVINLRGTVIPVMDLRKRFELPERAPLEESRLLVVTVSRQLVGLVVDDVTEVVTVQAHDIKPPPHVAEGISTEYLIGVCLVRDSLIMLLNLDTILNSRETSALAGFSRASGATPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TC9</accession>
    <name>Q39TC9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2269"/>
    <dbReference type="EnsemblBacteria" id="ABB32495">
        <property type="protein sequence ID" value="ABB32495"/>
        <property type="gene ID" value="Gmet_2269"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2269"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_7"/>
    <dbReference type="OMA" id="RDNCLTH"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044248">
        <property type="term" value="P:cellular catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="199"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="22"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="296" mass="32277" checksum="49AF1DD254CB204C" modified="2005-11-22" version="1">MNSDNKLRGEESMGIGKVAVIGSGIMGHGISQVVATAGINVALNDISDQVLEKAKSHIAASLDRGIQRGKLTEEDKKSILGRISYTTDIAQAVKDADLVVEAAPENLELKHSIFRKLDQYCKPEAILASNTSQYSITELASVVANPSRVIGMHWFNPPVAMKLIEIIRGLETSDAVLNEIETFSAAVGKETVVCKDSQGFISTRVLVAMRLECYRLVEEGIATPEDIDKTLRLAFGHPMGQFELADFSGLDIEPAACEALTKTFGDRFRAPQILLHRVKAGKLGRKSGEGWYKYDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TF0</accession>
    <name>Q39TF0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366001.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2247"/>
    <dbReference type="EnsemblBacteria" id="ABB32474">
        <property type="protein sequence ID" value="ABB32474"/>
        <property type="gene ID" value="Gmet_2247"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2247"/>
    <dbReference type="eggNOG" id="ENOG502Z7HQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048734_0_0_7"/>
    <dbReference type="OMA" id="HRVWVVK"/>
    <dbReference type="OrthoDB" id="451285at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010752">
        <property type="entry name" value="DUF1329"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07044">
        <property type="entry name" value="DUF1329"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223376" evidence="1">
        <location>
            <begin position="24"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="444" mass="50070" checksum="2A390B5870882DC3" modified="2005-11-22" version="1">MKFTKIIIGALVVSTSYVGGAQAGLPSHLTPAGAEKAGNKDGTIPAWTGGYTGRPAGFVKGMGNLPDPFASDKVLFSITGKNMDKYADKLSDGQKALLKKYPNFRMDVYQTRRSAAYTQSFEENTEKNMTRCRTTDGGISLDTSKGCGHGIPFPVPKNGYEVMWNHFARPALPAMIYKVGGYFVKPSGEVVQTQSTFMYREYGIYNPSKKNPDQYWMYRGEYIGPARINGQTSIITDYVDSKIGRRAYSYQPASRRVRLSPDAAADTPISQVAGVYTYDDADMFSGLMDRFDFKLVGKKEMYIPYNTYKLCLTKKEQQLRAGFANPDVMRWELHRVWVVEARLKPGKRHIYSKRMIYLDEDAWFGGVMDDYDSKGKLFMSEIVPLMPNYDVKAPAVDVQQFHNLVTGIFYTQVPEFGYKPVRFLPPGKLTQDSMTSFILKENMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TH5</accession>
    <name>Q39TH5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32449">
        <property type="protein sequence ID" value="ABB32449"/>
        <property type="gene ID" value="Gmet_2222"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2222"/>
    <dbReference type="HOGENOM" id="CLU_1568511_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="170" mass="18127" checksum="2F6DBDA0A653593A" modified="2005-11-22" version="1">MSCSISPEPWPGGVPRAAGASSSSVIASPANGGGYFLSQTPGSGIEALAMMSPPAGMRANHRFWVDDWEGFVARARTLVEEGRPDEIVLERPTGRFPVIARAATVLNLWVDHNAIEQCEFLSGLSVPLLHTLGGKGSSSRPDPRERGLDCRSMGRAGDAGRHPRLRTLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TJ8</accession>
    <name>Q39TJ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2199</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365955.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2199"/>
    <dbReference type="EnsemblBacteria" id="ABB32426">
        <property type="protein sequence ID" value="ABB32426"/>
        <property type="gene ID" value="Gmet_2199"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2199"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_9_0_7"/>
    <dbReference type="OMA" id="AWVHFPE"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="125"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="230"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="388" mass="43909" checksum="730E731E9A78BE20" modified="2005-11-22" version="1">MEIELNSRESAILEEVRRFLKSEVTPELLAESHHLEYIYGGEEGRKFVRKFAANGWLTPCWPEEYGGLNSSEMLMYAIRNEMAYARVPIHFAGAHMAGPSILRYGNDDLKKNYLLRLASGEIEFALGYSEPAAGSDLMGLEMRAADKGDHLIVNGQKTFNTHAHVADYHWLAVRTNLEGPKHKGISILIVDLKSPGITIRPMITMAGTRTNEVFYDDVVVPRANLVGEINSGFKYIMAALDFERMFPFGHYKKFYEDLVAYLKTVTRNGMPLTKDPLVRQKLAQLEIELEIIHHLYFQLAHMLDNGKIPNYQASMEKNFLTDFEQRLANTALEILGARGQLREGANGAILDGLPEWLYRWTVIETIYGGTAEIQRNIMAQRGLGLPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TL7</accession>
    <name>Q39TL7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365936.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2178"/>
    <dbReference type="EnsemblBacteria" id="ABB32407">
        <property type="protein sequence ID" value="ABB32407"/>
        <property type="gene ID" value="Gmet_2178"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2178"/>
    <dbReference type="eggNOG" id="COG1621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_326190_0_0_7"/>
    <dbReference type="OrthoDB" id="809817at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.130">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="SSF75005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_32N" evidence="2">
        <location>
            <begin position="465"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="883" mass="95982" checksum="5DDA05B6B731EFE1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TQ5</accession>
    <name>Q39TQ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MobA-related glycosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pcmX</name>
        <name evidence="2" type="ordered locus">Gmet_2140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513065.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2140"/>
    <dbReference type="EnsemblBacteria" id="ABB32369">
        <property type="protein sequence ID" value="ABB32369"/>
        <property type="gene ID" value="Gmet_2140"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2140"/>
    <dbReference type="eggNOG" id="COG2068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061980_3_0_7"/>
    <dbReference type="OMA" id="LFGAAHW"/>
    <dbReference type="OrthoDB" id="1432587at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017696">
        <property type="entry name" value="Mo_hydrolase_YgfJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03310">
        <property type="entry name" value="matur_MocA_YgfJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="9"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="202" mass="22036" checksum="CD5152B56ED5B284" modified="2005-11-22" version="1">MEARPRVAGIVLAAGKSTRMGRPKQLLPFRGRTVLECVVDNALASRLHRVVVVLGHEAEAVMPLLGHRCVTTVVNPLYGEGQSSSLKAGLGAMTEETDAALFLLGDQPLVTADTINLLIAAFADFPSPIVIPTFEGHRGNPVLFSRETFPRIEALSGDRGARGLFREYGDDIRSIDVRTPAILFDLDTEEDYLRLLREFPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TT7</accession>
    <name>Q39TT7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513096.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2108"/>
    <dbReference type="EnsemblBacteria" id="ABB32337">
        <property type="protein sequence ID" value="ABB32337"/>
        <property type="gene ID" value="Gmet_2108"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2108"/>
    <dbReference type="eggNOG" id="COG1418">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092695_0_0_7"/>
    <dbReference type="OMA" id="CEIIDGH"/>
    <dbReference type="OrthoDB" id="1688735at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="28"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="190" mass="21958" checksum="E6B9BC0271E0F92D" modified="2005-11-22" version="1">MREMSKIYEHIYDLARPHLNTRNNDIHTNVAYRFALRLLEDEPGDPDVVIPAIICHDIGWIKLPEALHSKAFGPGFDPDLRRVHEVEGVELAREILRSVAYDPHKSREILEIIEGHDSRLEAISDSDKIVKDADKLWRVTSEGLAIDAEWFRQEPEEHLHWTAVQIDSWFFTETGRQLAWAALEKAGYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TV5</accession>
    <name>Q39TV5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365915.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2090"/>
    <dbReference type="EnsemblBacteria" id="ABB32319">
        <property type="protein sequence ID" value="ABB32319"/>
        <property type="gene ID" value="Gmet_2090"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2090"/>
    <dbReference type="HOGENOM" id="CLU_1675400_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="157" mass="17779" checksum="FE98C279FFF11905" modified="2005-11-22" version="1">MGKSEMLREVLLKEYDTMRTEIRLYIGKYYIAITLIYTILSAGLLKENPTENNGMIYIWIPYIIAAIIGFMTMITFYVSKMVGYVRLIELRIAKSFGTEPPQNKAAVPKKILLAPLFWESTYADIDMNRDSGRQLVSPFFLSVSVMVISALTALAGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TY0</accession>
    <name>Q39TY0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein-associated cytochrome b and CCG domain pair iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2065</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514038.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2065"/>
    <dbReference type="EnsemblBacteria" id="ABB32294">
        <property type="protein sequence ID" value="ABB32294"/>
        <property type="gene ID" value="Gmet_2065"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2065"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_7"/>
    <dbReference type="OMA" id="RSKHMHI"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="267"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="332"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="658" mass="73108" checksum="0711616143E5F6C1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U29</accession>
    <name>Q39U29_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Aminotransferase, AHBA_syn family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512934.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2016"/>
    <dbReference type="DNASU" id="3740673"/>
    <dbReference type="EnsemblBacteria" id="ABB32245">
        <property type="protein sequence ID" value="ABB32245"/>
        <property type="gene ID" value="Gmet_2016"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2016"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059313_2_0_7"/>
    <dbReference type="OMA" id="FYFARNA"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="388" mass="44428" checksum="BD6AA4AE8FA4ED1B" modified="2005-11-22" version="1">MKVSSKPSLTWEILTSRADRPRQEVFPFNTGRCEYFYSARYALAAALDALKLSPQQSILMPSYNCWVEVEPAVRSGAKIDWYRVKTDFSIDEDDLLARIRPETAAIFVIHYLGFPQRLENIHRICTERGIVLIEDCAHALLSNDGDVPLGLTGDMAIFSIRKTVPIPDGGCLLINNPAFSVNRPRRVRPNLFATYFVVSEMLARGSTTEPKRVNQMAYSCNFAFARLARMGLRGIHKIFQDHGDYLVYPSGNHFNEQVKHWMMSDVSSAILRGTEFQRIKERRRANFLHLLDKLIMNDRITLPILSLPEGVSPLFFPVIVQDRDRVYRQLKDQGLSGHDWWGDFHPAVPWDKYPDAVYLKTNVFGFPVHQDLSRESLGIMLAEFSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U35</accession>
    <name>Q39U35_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2010"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32239">
        <property type="protein sequence ID" value="ABB32239"/>
        <property type="gene ID" value="Gmet_2010"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2010"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_0_7"/>
    <dbReference type="OMA" id="LYVNSAC"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="305" mass="35528" checksum="3B30E4EC83050AB9" modified="2005-11-22" version="1">MVKVTIIIPTYNPREHLIDTLLSVRTQNFTNIEVLIVDDGSTVDVSTLIKPYITADNIRCIRRKNGGTAAARNTGITNSTGEYIAFLDHDDIWLPDKVALQVEALDRNLSCGLTYCNFQILDEQTGSLINPHRQGEGGCMFEKFLYRNYITTASQIMVRRSCFDQLGLFDESLPIVDDYDFYLRLSRCYDIHYDPRVLTHWRSHQFNTSKNYEKTQLGRIKVKETALNRWALSDNQKKILFKGLRRDYYELAYYYLNSEKYSDARNYFRKAVPYRPVKSIVYYLSTCVPGLSYLNMKALKNDFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UA6</accession>
    <name>Q39UA6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amidophosphoribosyltransferase</fullName>
            <shortName evidence="5">ATase</shortName>
            <ecNumber evidence="5">2.4.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Glutamine phosphoribosylpyrophosphate amidotransferase</fullName>
            <shortName evidence="5">GPATase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 11" type="primary">purF</name>
        <name evidence="11" type="ordered locus">Gmet_1939</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = 5-phospho-alpha-D-ribose 1-diphosphate + H2O + L-glutamine</text>
            <dbReference type="Rhea" id="RHEA:14905"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="EC" id="2.4.2.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5 8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5 9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5 6">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5 6">In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.14" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511904.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1939"/>
    <dbReference type="MEROPS" id="C44.001"/>
    <dbReference type="EnsemblBacteria" id="ABB32168">
        <property type="protein sequence ID" value="ABB32168"/>
        <property type="gene ID" value="Gmet_1939"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1939"/>
    <dbReference type="eggNOG" id="COG0034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022389_3_1_7"/>
    <dbReference type="OMA" id="ENAQPTF"/>
    <dbReference type="OrthoDB" id="267682at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00124"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004044">
        <property type="term" value="F:amidophosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00715">
        <property type="entry name" value="GPATase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01931">
        <property type="entry name" value="PurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005854">
        <property type="entry name" value="PurF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035584">
        <property type="entry name" value="PurF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000485">
        <property type="entry name" value="Amd_phspho_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01134">
        <property type="entry name" value="purF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="5 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5 6" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="10">
        <location>
            <begin position="10"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5 7">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 8">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 9">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000485-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="466" mass="51351" checksum="DE301BF95D484177" modified="2005-11-22" version="1">MKLYRPTEECGIFGIYGHPEAANLTYLGLYALQHRGQEACGIVSSDGRSLHVHRSMGLVADVFGDQAIFRNLPGEAAIGHVRYSTTGDSVTKNVQPIKVDYSRGSIAVAHNGNLVNAQMVKDELEAWGSIFQTTMDTEVILHLLASSKQNALEDRIAEALGRLKGAYCLLFLTETRMVAARDPQGFRPLCLGKLGDGWVVASESCALDLIEAEFIREVEPGEVIVITKDGITSHFPLKKSEAAPCIFEFVYFARPDSYIFGKNVYMVRKDFGRQLAREHQVDADIVIPVPDSGVPAALGYAQEAGLPFELGLIRNHYIGRTFIEPQQSIRHFGVKIKLNPVREILEGKRVVVIDDSIVRGTTSRKIVKMVRNAGAKEVHVRISSPPTSYPCYYGIDTPTRKELISSSHTIEEIRRYITADSLGYLSEEGLLKAVGAGENPFCKACFSGNYPITFPKLAAAPQLDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UK6</accession>
    <name>Q39UK6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Translation elongation factor P-lysine lysyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">genX</name>
        <name evidence="3" type="ordered locus">Gmet_1839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512007.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1839"/>
    <dbReference type="EnsemblBacteria" id="ABB32068">
        <property type="protein sequence ID" value="ABB32068"/>
        <property type="gene ID" value="Gmet_1839"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1839"/>
    <dbReference type="eggNOG" id="COG2269">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_1_0_7"/>
    <dbReference type="OMA" id="ERFMAAM"/>
    <dbReference type="OrthoDB" id="63621at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004525">
        <property type="entry name" value="EpmA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00462">
        <property type="entry name" value="genX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="2">
        <location>
            <begin position="14"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="307" mass="34815" checksum="347132E3E0DD1CC8" modified="2005-11-22" version="1">MTANWRLARRHGALRARARIIQEIRRFFIEGGYLEVETPLRIPACAPESHIDPVPADGWFLQTSPEICMKRMLAAGYERLFQISHCWRAGERGRMHVPEFTMLEWYRAGTDYRGVMDETELLIRFVAEGAGFGGPLSFRGKEIDITAVWERITVRDAFVRYGGITMDEALERDIFDEMMVEQIEPRLGIGRPTFIHDYPSCRSALARLKKDDPAVAERFELYLGGVEIANAFSELTDPVEQRARFESENAFRTSRGQTSTPLPEKFLAELTAMPQAAGIALGIDRLVMVLLDADTIDDVVAFPPEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V12</accession>
    <name>Q39V12_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zinc metalloendopeptidase, M23 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511383.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1681"/>
    <dbReference type="EnsemblBacteria" id="ABB31912">
        <property type="protein sequence ID" value="ABB31912"/>
        <property type="gene ID" value="Gmet_1681"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1681"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089250_0_0_7"/>
    <dbReference type="OMA" id="PAHDIFV"/>
    <dbReference type="OrthoDB" id="1612575at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223531" evidence="1">
        <location>
            <begin position="22"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="2">
        <location>
            <begin position="124"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="241" mass="26519" checksum="BF8D9EF0C3DD2FD6" modified="2005-11-22" version="1">MKQIILLAVAAFLALNGVAAASPCDDWNILEKEIRDGRIDRISAKTRIAQLHRLLLDTYGTTAANSAKVFPVADYDYRAIGGRHGNDYRPGGYSFYQGVRHGGHPAHDIFVHDRNQDSLDDATGKPVTIVASANGVVIATNPSWDYPSPVRGGKYVWIFNTAEERYYYYAHLSSVTVMPGQTVTAGEPIGFLGRTGKNAYPRRSPTHLHFMVLSYADGRMLPINPYRELVGAGRGIVKTSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V14</accession>
    <name>Q39V14_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding domain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511385.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1679"/>
    <dbReference type="EnsemblBacteria" id="ABB31910">
        <property type="protein sequence ID" value="ABB31910"/>
        <property type="gene ID" value="Gmet_1679"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1679"/>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1183265_0_0_7"/>
    <dbReference type="OrthoDB" id="1315067at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039561">
        <property type="entry name" value="Peptidase_M15C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13539">
        <property type="entry name" value="Peptidase_M15_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PG_binding_1" evidence="1">
        <location>
            <begin position="17"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M15_4" evidence="2">
        <location>
            <begin position="166"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="230" mass="25314" checksum="A75BBED004A9E6E1" modified="2005-11-22" version="1">MSVLQASVGYLGKNIENDVETVQSLLKSKGFDPKGIDGVCGKDTIAAIRSFQATFMTNPDGLIEPGRKTWLKLAGTGGAATADLSPWCGDSARWSQEKKLQSMHPELRQKVAAVLQALAGRGFQPKVFYGWRSVAVQMQLYYQGNSKVKFSFHNAQHPDGIPNAYAADIVDSRFGWAPEAEQTGFWKALGEEAKELGLVWGGDWVNFRDWAHVQLVPNDELGRVKRESGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VB5</accession>
    <name>Q39VB5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan L,D-transpeptidase, YkuD family, LysM domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31809.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511488.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1577"/>
    <dbReference type="EnsemblBacteria" id="ABB31809">
        <property type="protein sequence ID" value="ABB31809"/>
        <property type="gene ID" value="Gmet_1577"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1577"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_972402_0_0_7"/>
    <dbReference type="OMA" id="YPGMTIK"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="119"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31809.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="288" mass="32562" checksum="9D07550FE46523D7" modified="2012-10-31" version="2">MIRKLAYVIALLIFAAIVIRQPESTADPSASPKDSSKEDLSRIDYPSLRKIDWKPHFIKPNETLESLFGNDWVTVARFNRIDRRHTYPGMTIKVPADMAAARSYTPLPLEYEPAKRYQKFILISLTEQWIGAYENGKLKFSMPAATGKTGHETPTGLFRIDARHRTHTSSLYQTDDLSAQYPMDFAMRFHIGADNVSYWIHARDLPGKPASHGCVGLFDESMQNRMYGIPAKPVLFDSKKLYDWAVGESEYGEDSGELELIDDAPVVEVTGENPVYQPFPLKPMAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VH3</accession>
    <name>Q39VH3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Lipoprotein release ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">lolE-2</name>
        <name evidence="10" type="ordered locus">Gmet_1517</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511550.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1517"/>
    <dbReference type="EnsemblBacteria" id="ABB31751">
        <property type="protein sequence ID" value="ABB31751"/>
        <property type="gene ID" value="Gmet_1517"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1517"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012341_0_0_7"/>
    <dbReference type="OMA" id="PQSFHWT"/>
    <dbReference type="OrthoDB" id="856767at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="724"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="765"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="816"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="20"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="286"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="488"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="750"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="851" mass="91611" checksum="03A5BEE555A7B622" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VN2</accession>
    <name>Q39VN2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Filamentous hemagglutinin-like outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1458</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511612.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1458"/>
    <dbReference type="EnsemblBacteria" id="ABB31692">
        <property type="protein sequence ID" value="ABB31692"/>
        <property type="gene ID" value="Gmet_1458"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1458"/>
    <dbReference type="eggNOG" id="COG3210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000163_1_0_7"/>
    <dbReference type="OMA" id="QDTIRGH"/>
    <dbReference type="OrthoDB" id="1093at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021026">
        <property type="entry name" value="Filamn_hemagglutn_DUF3739"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008638">
        <property type="entry name" value="Filamn_hemagglutn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12545">
        <property type="entry name" value="DUF3739"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05860">
        <property type="entry name" value="Haemagg_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00912">
        <property type="entry name" value="Haemagg_act"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01901">
        <property type="entry name" value="adhes_NPXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223544" evidence="2">
        <location>
            <begin position="30"/>
            <end position="3299"/>
        </location>
    </feature>
    <feature type="domain" description="Haemagg_act" evidence="3">
        <location>
            <begin position="62"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3237"/>
            <end position="3264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="3299" mass="339142" checksum="F4FB5F7480DDA896" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VU4</accession>
    <name>Q39VU4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pilS</name>
        <name evidence="8" type="ordered locus">Gmet_1396</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513112.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1396"/>
    <dbReference type="EnsemblBacteria" id="ABB31630">
        <property type="protein sequence ID" value="ABB31630"/>
        <property type="gene ID" value="Gmet_1396"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1396"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_7"/>
    <dbReference type="OMA" id="ICRELCQ"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="200"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="7">
        <location>
            <begin position="265"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="330"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="547" mass="60774" checksum="4A8E891A36290F4F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W74</accession>
    <name>Q39W74_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="4">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pssA</name>
        <name evidence="9" type="ordered locus">Gmet_1264</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512103.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1264"/>
    <dbReference type="EnsemblBacteria" id="ABB31500">
        <property type="protein sequence ID" value="ABB31500"/>
        <property type="gene ID" value="Gmet_1264"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1264"/>
    <dbReference type="eggNOG" id="COG1183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049944_2_0_7"/>
    <dbReference type="OMA" id="IFFDFFD"/>
    <dbReference type="OrthoDB" id="1232102at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="259" mass="29039" checksum="8D23B05E71C0B4F2" modified="2005-11-22" version="1">MNGEKIDMSESMRKGIYILPNLFTTGSLFAGFYGMVATMNGDFKTAALWILVSSIFDGLDGKVARLTGTSSKFGVEYDSLADVVSFCVAPALLTYKWALQPFGRLGWLAAFLFVACGALRLARFNVQVNTVESKRFVGLPTPAAASMVSAMVLLFYHFGWPSSYKKLAILVLIYLLAFLMVSNFRYYSFKDPELIKRQPFAFLVLAVLLLVVIAAEPVVMLFLIFICYTFSGIVGFLMTWPRRRRLEKAIHNKHTKEEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WH8</accession>
    <name>Q39WH8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Periplasmic energy transduction protein, TonB-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_1158</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
            <orientation evidence="1">Periplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TonB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513423.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1158"/>
    <dbReference type="EnsemblBacteria" id="ABB31396">
        <property type="protein sequence ID" value="ABB31396"/>
        <property type="gene ID" value="Gmet_1158"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1158"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979202_0_0_7"/>
    <dbReference type="OMA" id="WRYPQEA"/>
    <dbReference type="OrthoDB" id="1305648at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006260">
        <property type="entry name" value="TonB/TolA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037682">
        <property type="entry name" value="TonB_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03544">
        <property type="entry name" value="TonB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01352">
        <property type="entry name" value="tonB_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_C" evidence="11">
        <location>
            <begin position="212"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="53"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB31396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="297" mass="33500" checksum="1163399FFCB44E40" modified="2005-11-22" version="1">MPDKYVEKSFLYLVALSLLLHVGLFALIILYPQAKPVLRQEPIMIDLEDIPDLRQAPMPTDSRREVRRQAEQPRRVPREMAPRGDRERDRIASLPPVAKPIPSRPAVPYQAAPQPRRGEGVGPSATNGRTGEIPVREAPRGGGILKPRASAEAPELAQLMPSAQRLAKIEESYRKKYRDDVADGDTKFLDTDDIQFGSFLRRFENAIYGVWRYPQEAARLGIEGVTPVKITFNRSGVIVKYEILQSSGSRILDDEVLRTLRMVGPVGPFPRGYDRDEFHLIAFFQYGIVRGASRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WN1</accession>
    <name>Q39WN1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription elongation factor GreB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Transcript cleavage factor GreB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">greB</name>
        <name evidence="7" type="ordered locus">Gmet_1103</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GreA/GreB family. GreB subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513759.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1103"/>
    <dbReference type="EnsemblBacteria" id="ABB31343">
        <property type="protein sequence ID" value="ABB31343"/>
        <property type="gene ID" value="Gmet_1103"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1103"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101379_3_0_7"/>
    <dbReference type="OMA" id="DQIFFGA"/>
    <dbReference type="OrthoDB" id="1591985at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00105">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00930">
        <property type="entry name" value="GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018151">
        <property type="entry name" value="TF_GreA/GreB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028624">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022691">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036805">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006358">
        <property type="entry name" value="Tscrpt_elong_fac_GreB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03449">
        <property type="entry name" value="GreA_GreB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46557">
        <property type="entry name" value="SSF46557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01461">
        <property type="entry name" value="greB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00829">
        <property type="entry name" value="GREAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00830">
        <property type="entry name" value="GREAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1 4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="GreA_GreB_N" evidence="6">
        <location>
            <begin position="7"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="5">
        <location>
            <begin position="84"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="161" mass="18148" checksum="F9BE0DCD27DEE2FE" modified="2005-11-22" version="1">MAKQSDYITPEGAKKLRDELAWLWKEERPRVTQGVSDAAAEGDRSENAEYIYGKKRLREIDRRIRFLTQRLDHLTVVEDPPPATGKVFFGAWIRLETEEGDEVIYRVVGPDETDASKGFISIDSPMGKALLGRNEGDEVPVRRPAGEAVFTVLEVAYQPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WP7</accession>
    <name>Q39WP7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513743.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31327">
        <property type="protein sequence ID" value="ABB31327"/>
        <property type="gene ID" value="Gmet_1087"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1087"/>
    <dbReference type="HOGENOM" id="CLU_151849_0_0_7"/>
    <dbReference type="OrthoDB" id="1466012at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="148" mass="15183" checksum="EFE199DC38827A4E" modified="2005-11-22" version="1">MKFRTFTLTEILTLAIAFAAYGVICITGTATGSTGGASLTTGHGQTLSDTSSAGTPAATEDFRGSADFPEPSPVRKTAKKTVAQRSMPVDGASLYYTSNCAGCHGTMSNLRGATAEMIQSAIDSNAGGMGFHVTLSPEEIHSIADALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WQ6</accession>
    <name>Q39WQ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Methyl-accepting chemotaxis sensory transducer, class 36H, Cache_2 domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">mcp36H</name>
        <name evidence="13" type="ordered locus">Gmet_1078</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513734.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1078"/>
    <dbReference type="EnsemblBacteria" id="ABB31318">
        <property type="protein sequence ID" value="ABB31318"/>
        <property type="gene ID" value="Gmet_1078"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1078"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_21_7"/>
    <dbReference type="OMA" id="ITHLGEH"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004010">
        <property type="entry name" value="Double_Cache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033480">
        <property type="entry name" value="sCache_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08269">
        <property type="entry name" value="dCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01049">
        <property type="entry name" value="Cache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0807">Transducer</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="216"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="11">
        <location>
            <begin position="273"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="520"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="292"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="563"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="587" mass="63050" checksum="DED6AEB1733C6159" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WV1</accession>
    <name>Q39WV1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">frx-2</name>
        <name evidence="5" type="ordered locus">Gmet_1033</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31273.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513206.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1033"/>
    <dbReference type="EnsemblBacteria" id="ABB31273">
        <property type="protein sequence ID" value="ABB31273"/>
        <property type="gene ID" value="Gmet_1033"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1033"/>
    <dbReference type="eggNOG" id="COG2221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_11_4_7"/>
    <dbReference type="OMA" id="PAECIVQ"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31273.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="56" mass="5544" checksum="14A67F08A7461A02" modified="2012-10-31" version="2">MAHVISDDCTNCGSCVDSCPVNAIAPAGDKHKIDGDTCIDCGACVDTCPTSAISAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WZ2</accession>
    <name>Q39WZ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Phosphoglucomutase/phosphomannomutase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_0990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514385.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0990"/>
    <dbReference type="EnsemblBacteria" id="ABB31232">
        <property type="protein sequence ID" value="ABB31232"/>
        <property type="gene ID" value="Gmet_0990"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0990"/>
    <dbReference type="eggNOG" id="COG1109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016950_7_1_7"/>
    <dbReference type="OMA" id="RGHVREK"/>
    <dbReference type="OrthoDB" id="637615at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016868">
        <property type="term" value="F:intramolecular transferase activity, phosphotransferases"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="SSF53738"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="SSF55957"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PGM_PMM_I" evidence="7">
        <location>
            <begin position="4"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_II" evidence="8">
        <location>
            <begin position="165"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_III" evidence="9">
        <location>
            <begin position="270"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="PGM_PMM_IV" evidence="6">
        <location>
            <begin position="403"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="472" mass="51405" checksum="4522DBBF9FEA63C0" modified="2005-11-22" version="1">MHRIAFGTSGWRGILCEDFTFENVKVVTQAIADHVTSIGEKEKGIIVAYDTRFMGERFAKETARVLAGAGIKAYVCKRDTPTPVVSHEILRRKAAGAINFTASHNPPEYNGIKFSPSWAGPALPETTKDIERRANEMLGEVCYREVALDEAARAGLVEEIDPRETYLADIETKVDFTAIASLGTIAVNVLYGTARGYLDEPLMKHGAKIKTLNMHPDPYFGGFPPEPSEKYIQDFIGLVKSDPAVKLGIATDGDADRFGIVDADGSFIEPNYIIALLFDYLVRVRKMTGAVARSVATSHLIDAVAKKHGIEVIETPVGFKYVGELISQDRIIIGGEESAGLSIKGHVPEKDGILACFLVAEMVAREGLSVKALLERLYGEVGRFLTKRENITLSPVLEAGYADKQRQAPAEFAGLKVKDMVTVDGSKFILEDGSWLLFRKSGTEPVVRLYGEASSEEKLAAVMAAGKAFILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X73</accession>
    <name>Q39X73_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365743.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0909"/>
    <dbReference type="EnsemblBacteria" id="ABB31151">
        <property type="protein sequence ID" value="ABB31151"/>
        <property type="gene ID" value="Gmet_0909"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0909"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141296_0_0_7"/>
    <dbReference type="OMA" id="QSCTRCH"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223407" evidence="1">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="259" mass="29468" checksum="DA6DFDEEC4458320" modified="2005-11-22" version="1">MRKWLMFTMLLAMAALYSRQATAERKENHKDYASSSIAECSSCHKGEGVAPNHDSDWVRGHRLVAQKPGRNCNDCHDQAFCLDCHTGGGIDTSPSNQTFRRDYKPKSHRSDFLEIHPIKAMDNPQSCTRCHSEQKFCIECHERFRANDLQFQSHRRQFSDIQLSNVGPKHEGFSATQCQSCHPGGMLPTHKWSADHAVEARRNLQACQTCHSEGDVCMRCHSARTGLKVSPHPRNWDSVKGNYRDKSNGRSCVKCHDHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X90</accession>
    <name>Q39X90_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365738.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0892"/>
    <dbReference type="EnsemblBacteria" id="ABB31134">
        <property type="protein sequence ID" value="ABB31134"/>
        <property type="gene ID" value="Gmet_0892"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0892"/>
    <dbReference type="HOGENOM" id="CLU_1882787_0_0_7"/>
    <dbReference type="OMA" id="MCPICGW"/>
    <dbReference type="OrthoDB" id="1638444at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="136" mass="15534" checksum="EAD377144336D49D" modified="2005-11-22" version="1">MMPNDMHEACEQCRFAYARIDTECWGEQGARRVMCPICGWTKYEEHSWGSGTATLTKRSVKRGHGAYRLIPPGGFSGYNAFHEPPTPEVVRHIQALLDRGWKGYLTIWDEERAKARLVAGHPLQRYEIPDEEGNAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XA4</accession>
    <name>Q39XA4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein phosphohistidine phosphatase SixA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">sixA</name>
        <name evidence="1" type="ordered locus">Gmet_0878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31120.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365736.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0878"/>
    <dbReference type="EnsemblBacteria" id="ABB31120">
        <property type="protein sequence ID" value="ABB31120"/>
        <property type="gene ID" value="Gmet_0878"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0878"/>
    <dbReference type="eggNOG" id="COG2062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084603_3_1_7"/>
    <dbReference type="OMA" id="SQMFWLT"/>
    <dbReference type="OrthoDB" id="1707924at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101006">
        <property type="term" value="F:protein histidine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004449">
        <property type="entry name" value="SixA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00249">
        <property type="entry name" value="sixA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31120.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="166" mass="18026" checksum="8EC6B7CBC7309BEE" modified="2012-10-31" version="2">MKLYLIRHGEAVERGETVREEDRWLTAVGRDGFRANARRLAKKVVAPEVIVTSPLVRAVQTADILAEVLGFSGEVTVSQELAPGFSSEGLFRLAGVRGSPRSLAVVGHEPDLGEVFGRLLGRDGALPLKKGAIVALRLDSAESGTPARFLWMIQRGKKFRELPEPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XE9</accession>
    <name>Q39XE9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-amylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512977.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0833"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31075">
        <property type="protein sequence ID" value="ABB31075"/>
        <property type="gene ID" value="Gmet_0833"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0833"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031181_0_0_7"/>
    <dbReference type="OMA" id="FHIFGEV"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="1">
        <location>
            <begin position="34"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="617" mass="69225" checksum="B402D4F68207E0DC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XF5</accession>
    <name>Q39XF5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0827</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514414.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0827"/>
    <dbReference type="EnsemblBacteria" id="ABB31069">
        <property type="protein sequence ID" value="ABB31069"/>
        <property type="gene ID" value="Gmet_0827"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0827"/>
    <dbReference type="HOGENOM" id="CLU_1822228_0_0_7"/>
    <dbReference type="OMA" id="FERYNHT"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223249" evidence="1">
        <location>
            <begin position="30"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="156" mass="18006" checksum="D1FFF050038574C9" modified="2005-11-22" version="1">MKKGMILTLLATGLILALLAACASTPAYRLPAKHPNIYELGDRREFCTKCHGYKKTPVDFERYNHTPLFTESHRLVAYQDQRICALCHEQSFCNDCHVTHTELKPSVKNQTENYRRMQHRGEYLSRHRIDGRLDPTSCYRCHGNPQSSQTCRPCHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XG9</accession>
    <name>Q39XG9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane-bound serine protease NfeD, long form</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">nfeD</name>
        <name evidence="5" type="ordered locus">Gmet_0813</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514400.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0813"/>
    <dbReference type="EnsemblBacteria" id="ABB31055">
        <property type="protein sequence ID" value="ABB31055"/>
        <property type="gene ID" value="Gmet_0813"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0813"/>
    <dbReference type="eggNOG" id="COG1030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024619_1_0_7"/>
    <dbReference type="OMA" id="QMDTPGG"/>
    <dbReference type="OrthoDB" id="973681at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002810">
        <property type="entry name" value="NfeD-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01957">
        <property type="entry name" value="NfeD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223592" evidence="3">
        <location>
            <begin position="22"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="NfeD" evidence="4">
        <location>
            <begin position="344"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="446" mass="47077" checksum="A9615F2B7E068E3D" modified="2005-11-22" version="1">MHRIITLCILLCCLLPAVALPADSATVRVLGVRSAINPVTASFLKRNLVDAARRGDRLVLIDMDTPGGLDTAMREIVKDILASPVPVAVHVAPSGARAASAGAIICLAADICAMAPGTTIGAAHPVSIGEKQDKVMEEKVVNDAEAYAEGLANRRGRNAAVARRMVRESLSLSAEKALAEKVVDLIAADRASLLAQLEGRRVARPGGDVVLGLAGAVVREEPMTARERILDVIGNPNVAYILMMLGFLGIFFELSNPGVILPGVIGGISLILAFFAFQTLPVNYAGVLLILLALILFIAEIKIVSHGMLTVGGVIAMVLGSLLLFESPEPYLRVSWQVIAITVIAISAFSVFAVTMAVRVHRRKPTTGGEGLLGESGKALSAISPEGRVFIHGEYWDAWSDEPLAEGDRVTVVAVEGMRVKVRKTGDRGPGKAFRQGLPCDAVIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XK6</accession>
    <name>Q39XK6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513521.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0776"/>
    <dbReference type="EnsemblBacteria" id="ABB31018">
        <property type="protein sequence ID" value="ABB31018"/>
        <property type="gene ID" value="Gmet_0776"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0776"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="NCAAVPH"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="140"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="454" mass="50816" checksum="F00381663F9694C8" modified="2005-11-22" version="1">MNETILVVDDEQNIRTALAGILEDEGYRPVFAKDGLEALDMAKKENPDLVLLDIWMPRLDGLETLQALKEFHPLLTVVMMSGHGTIETAVKSTKLGAYDFIEKPLSLEKVLVTVKNGLDVGRLKAENDTLRTVAFKGHDMVGNTPAILQLQEQVRRVAATNASVLITGENGTGKELVARAIHHWSPRKEKPFVEINCAALPEELIESELFGHEKGAFTGAVAQKKGKFDLADGGTIFLDEIGDMSLKTQAKVLRILQERKFERVGGTKTIEVDVRVVAATNKDLPGEIRGGTFREDLFYRLNVVPFTVPPLRERRDDIPLLVEHFLAIFAQREGQERKKMLPETVELLKGYDWPGNVRELRNIIERLVIMTPGKVITPDQVPDTIGSAAGEAHRPGAPLELNSLREAREGFEREFILQKLEENGWNISRTAEAIELERSNLYRKMKSYGIDARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XK8</accession>
    <name>Q39XK8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbonic anhydrase, beta-family, clade D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513519.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0774"/>
    <dbReference type="EnsemblBacteria" id="ABB31016">
        <property type="protein sequence ID" value="ABB31016"/>
        <property type="gene ID" value="Gmet_0774"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0774"/>
    <dbReference type="eggNOG" id="COG0288">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084253_3_0_7"/>
    <dbReference type="OMA" id="AIFTCMD"/>
    <dbReference type="OrthoDB" id="1841447at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="PTHR43175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="SSF53056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="181" mass="19778" checksum="1DA3F474141EC744" modified="2005-11-22" version="1">MTLLDTILDANREFVRPGVFPPLPKNPRKQFAIFTCMDTRLVDFLEPAMGIKRGDAKVIKNAGNTIVDPMSGGVVRSLVAAIFMLGVEEIFVIGHQDCGMASVDAKALKERMIARGVDPAIIEAQVPDLAQWMGAFSCPEENVGRVVSVLRQNPLIPRDVPIHGLIFCPNDGHLDVVVRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y26</accession>
    <name>Q39Y26_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA pseudouridine synthase A</fullName>
            <ecNumber evidence="4">5.4.99.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridine(38-40) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA pseudouridylate synthase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-uridine isomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">truA</name>
        <name evidence="9" type="ordered locus">Gmet_0605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 7">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30848.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514735.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0605"/>
    <dbReference type="EnsemblBacteria" id="ABB30848">
        <property type="protein sequence ID" value="ABB30848"/>
        <property type="gene ID" value="Gmet_0605"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0605"/>
    <dbReference type="eggNOG" id="COG0101">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014673_0_1_7"/>
    <dbReference type="OMA" id="FLYGMVR"/>
    <dbReference type="OrthoDB" id="1075262at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02570">
        <property type="entry name" value="PseudoU_synth_EcTruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PTHR11142"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="9"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="PseudoU_synth_1" evidence="8">
        <location>
            <begin position="144"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4 5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 6">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30848.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="244" mass="26900" checksum="1D43B012D8979EC9" modified="2012-10-31" version="2">MHTIKLVLEYDGTNYAGWQIQPNGISVQQVVEEALARLLKEPVRVHSSGRTDAGVHARGMVAAFTTAKGLPMRAFSDGLNALLPPDIAVMEALEAPDGFNPRFDAAGKHYRYTIHRGERRSPLCRHYVWHARETLDLAAMEKGASHMVGEHDFASFRTAGCAARTTVRRIDAVDLALEGDLLHIDVKGSGFLRNMVRIMVGTLVEVGRGRRSADDVALLFRYPGERFAGPTAPPQGLCLMEVYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y28</accession>
    <name>Q39Y28_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 13">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="13">ASA dehydrogenase</shortName>
            <shortName evidence="13">ASADH</shortName>
            <ecNumber evidence="8 13">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">asd</name>
        <name evidence="15" type="synonym">asd-2</name>
        <name evidence="15" type="ordered locus">Gmet_0603</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 13">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7 13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="8 13"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514733.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0603"/>
    <dbReference type="EnsemblBacteria" id="ABB30846">
        <property type="protein sequence ID" value="ABB30846"/>
        <property type="gene ID" value="Gmet_0603"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0603"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066397_0_0_7"/>
    <dbReference type="OMA" id="MFDVPDE"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000319">
        <property type="entry name" value="Asp-semialdehyde_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011534">
        <property type="entry name" value="Asp_ADH_gamma-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46278:SF4">
        <property type="entry name" value="PTHR46278:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01745">
        <property type="entry name" value="asd_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01103">
        <property type="entry name" value="ASD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="14">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="13">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="271"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="37"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="162"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB30846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="366" mass="39766" checksum="39AD14D7E56D43AC" modified="2005-11-22" version="1">MKVGIVGWRGMVGSVLLQRMVEEGDFNTGIEPVFFSTSQAGQPAPMNAGTLKSADDIEELKKLDIIVTCQGGDYTKAVHPELRKQGWQGYWIDAASTLRMEPNAVIILDPVNRNVIDAALAKGQKDFIGGNCTVSLMLMALGGLFRAGLVEWLTSMTYQAASGAGAPNMRELLSQMGTLHGSVADLLKNPSSAILDIDRDVTATLRGDALPTKEFGFPLAGSVLPWIDREVEDGQSREEWKGFAETNKILGTTTPIPVDGICVRVGAMRCHSQALTIKLNKDVPLGDIEELIKNDNQWVKFVPNTKADTLADLTPAAVSGLLTVPIGRVRKMKMGPQYMQAFTCGDQLLWGAAEPLRRMLRILVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y87</accession>
    <name>Q39Y87_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(R)-2-hydroxyacyl-CoA dehydratase-radicalizing ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0544</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512240.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0544"/>
    <dbReference type="EnsemblBacteria" id="ABB30787">
        <property type="protein sequence ID" value="ABB30787"/>
        <property type="gene ID" value="Gmet_0544"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0544"/>
    <dbReference type="eggNOG" id="COG1924">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066597_2_0_7"/>
    <dbReference type="OMA" id="TCAVFGE"/>
    <dbReference type="OrthoDB" id="1837697at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002731">
        <property type="entry name" value="ATPase_BadF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008275">
        <property type="entry name" value="CoA_E_activase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01869">
        <property type="entry name" value="BcrAD_BadFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00241">
        <property type="entry name" value="CoA_E_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BcrAD_BadFG" evidence="3">
        <location>
            <begin position="3"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="263" mass="28328" checksum="67A2A47327126A4E" modified="2005-11-22" version="1">MRIGIDLGSRKAKFALLDGERIVRLADHDTVTFYKRYGRLAEDELELDLAASGIFSADELAGAAVVVTGYGRNTLSLKGAKVISEIRAHVAGALLQTGLRDFTLLDMGGQDTKVALVREGKLADFVMNDKCAASSGRYLENMAAILELSLDELSSHWEDPVKLDATCGIFGESELIGQILRGHPVERLCAGVNQTLVTRVMPMLKRFASETIVLTGGVAQNRGVVRLLEEKTRLTVIVPEHPQHNGAIGCAKFGDPGPGTGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y94</accession>
    <name>Q39Y94_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Menaquinol oxidoreductase complex Cbc6, cytochrome c subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cbcN</name>
        <name evidence="2" type="ordered locus">Gmet_0537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30780.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365677.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0537"/>
    <dbReference type="EnsemblBacteria" id="ABB30780">
        <property type="protein sequence ID" value="ABB30780"/>
        <property type="gene ID" value="Gmet_0537"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0537"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054357_0_0_7"/>
    <dbReference type="OMA" id="CHDNPRR"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223302" evidence="1">
        <location>
            <begin position="24"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30780.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="418" mass="46951" checksum="7B420CC84071B018" modified="2012-10-31" version="2">MPWMMHFIAVFWLAAALASPADGAENCRACHRDAVSGPHAAIGCTPCHGDDRSTVGNPATAVDRAARCVACHRGFDRLFDHAMATRTAERQFVARTVGRFDGGFWADNCTGCHVRGCLDCHGGKGHAMSRPRDGVCLDCHRGYFVGSDYHGRAPREDAFRFQRGPFAGGEQFLPMLPDVHAEAGIGCGGCHDMASLAAGRRSGKGCRDCHEPDQRIVEHRIPAHRERLECYACHSAWAPQEYGTFWLRFIDSPRRQARFTAIPHQDEWVKSAYLKRQDAPPLGLNSAGKVSPIRPQFILYFSDIRSERAVGEENRLLAAEWKAFFPHTVRRGTVMCDGCHDNPRRFLLEGEKERIYRLKDDGLSLESFWRREGQRVVNGSFMDPERVRKMAVRTPAYTKGYIEKWQRLTGDAGTSSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="129" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YB7</accession>
    <name>Q39YB7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Molybdate ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">modC</name>
        <name evidence="9" type="ordered locus">Gmet_0514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512210.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0514"/>
    <dbReference type="EnsemblBacteria" id="ABB30757">
        <property type="protein sequence ID" value="ABB30757"/>
        <property type="gene ID" value="Gmet_0514"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0514"/>
    <dbReference type="eggNOG" id="COG4148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_7"/>
    <dbReference type="OMA" id="QWLYAQI"/>
    <dbReference type="OrthoDB" id="1200451at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011868">
        <property type="entry name" value="ModC_ABC_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004606">
        <property type="entry name" value="Mop_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005116">
        <property type="entry name" value="Transp-assoc_OB_typ1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03459">
        <property type="entry name" value="TOBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02142">
        <property type="entry name" value="modC_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51866">
        <property type="entry name" value="MOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="7">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Mop" evidence="8">
        <location>
            <begin position="286"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="351" mass="38320" checksum="6A6FA145D80DD3A1" modified="2005-11-22" version="1">MELRVRGAKTFGAFHLAADFTVEGNRIGIFGESGSGKSTLVNMLAGLERPDSGEILLDGEPLFAADRRINVPPERRRVALVFQHPHLFPHLSVRGNLLYGWKRCAMANRQVGLDDIVDVLKIGRLLDRGVTNLSGGEKQRVALGRALLSNPRLLLMDEPLSALDDTLRFQIIPYLRGACEALAIPYLFISHSLVEMRLMAERVIVFSQGCQVADTTPDALARNRMGDSPVGYINLLRLTDPCDNDGLISYAWGGTRLFLTAPPGEGELLFELSSKDMILCKKHPEAISARNLFHCTVIGIFEAGRKAGVELQCGTGRLVAEVAAEAARELELTVGSEVFAAVKASAFRRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YB8</accession>
    <name>Q39YB8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Molybdenum transport system permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">modB</name>
        <name evidence="11" type="ordered locus">Gmet_0513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512209.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0513"/>
    <dbReference type="EnsemblBacteria" id="ABB30756">
        <property type="protein sequence ID" value="ABB30756"/>
        <property type="gene ID" value="Gmet_0513"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0513"/>
    <dbReference type="eggNOG" id="COG4149">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_3_7"/>
    <dbReference type="OMA" id="MYSFIET"/>
    <dbReference type="OrthoDB" id="1915735at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011867">
        <property type="entry name" value="ModB_ABC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02141">
        <property type="entry name" value="modB_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="12"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="227" mass="23959" checksum="FB25A3159DEB2339" modified="2005-11-22" version="1">MFSLTSADIDAIRLSAKVALAATVVSLPFGIAVAYVMSYCSFRGKTFVEVLLNLPLTLPPVVIGYLLLLLLGKKGWVGGLLDAAGIRIIFTWYAAVIASAAVGFPLLVRSIRIAMDSIDGRLIQASRTLGARWSDTLATVILPLSLRGIVAGSSLMFGRSLGEFGATIIVAGNIPGITQTIPLAVYDYVSAPGGEGAALALCLVSAGLSLLVLFFHEYLARRMARRD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YG6</accession>
    <name>ENGB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable GTP-binding protein EngB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">engB</name>
        <name type="ordered locus">Gmet_0465</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Necessary for normal cell division and for the maintenance of normal septation.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513834.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YG6"/>
    <dbReference type="SMR" id="Q39YG6"/>
    <dbReference type="STRING" id="269799.Gmet_0465"/>
    <dbReference type="EnsemblBacteria" id="ABB30708">
        <property type="protein sequence ID" value="ABB30708"/>
        <property type="gene ID" value="Gmet_0465"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0465"/>
    <dbReference type="eggNOG" id="COG0218">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033732_3_0_7"/>
    <dbReference type="OMA" id="DEMAFFS"/>
    <dbReference type="OrthoDB" id="1746051at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000917">
        <property type="term" value="P:division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01876">
        <property type="entry name" value="YihA_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00321">
        <property type="entry name" value="GTPase_EngB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019987">
        <property type="entry name" value="GTP-bd_ribosome_bio_YsxC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03598">
        <property type="entry name" value="GTPase_YsxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0717">Septation</keyword>
    <feature type="chain" id="PRO_0000266867" description="Probable GTP-binding protein EngB">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="EngB-type G" evidence="1">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="75"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="142"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="173"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="204" mass="22554" checksum="3B668F273F955823" modified="2005-11-22" version="1">MKVSSAEFVTSGTRPAHYPPPELPEVAFAGRSNVGKSSLINVLVNRKGLVRTSSTPGRTQLINFFRVNGSLMLVDLPGYGFAKVPLAVKKEWGPMVETYLSTRPNLSCVVLIVDIRREPTEEDQLMLQWLRAYNVAVLVVVTKCDKVSKNERAKQAAIITRTLGLARDEMAFFSALSKEGRDEVWARIEVMLAAGQEEAEESGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YJ4</accession>
    <name>Q39YJ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar biogenesis chaperone FlgN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">flgN</name>
        <name evidence="3" type="ordered locus">Gmet_0437</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the efficient initiation of filament assembly.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FlgN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512409.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0437"/>
    <dbReference type="EnsemblBacteria" id="ABB30680">
        <property type="protein sequence ID" value="ABB30680"/>
        <property type="gene ID" value="Gmet_0437"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0437"/>
    <dbReference type="HOGENOM" id="CLU_136712_0_0_7"/>
    <dbReference type="OMA" id="MIADNRR"/>
    <dbReference type="OrthoDB" id="1928806at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007809">
        <property type="entry name" value="FlgN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036679">
        <property type="entry name" value="FlgN-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05130">
        <property type="entry name" value="FlgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140566">
        <property type="entry name" value="SSF140566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="165" mass="18165" checksum="C82BAFFA2440CDA8" modified="2005-11-22" version="1">MSQGMTNLADVLHARRASMEEMIRLLAEEREATISCDTERLHEATARKLEVAAAMEVLDGNCRQLMANEAERLGLPANATLSPIIARSAPAEQAELTALQKKIAFLAGEIRQLVDDNRRFLGNSIATINRSLAFFQSRFTVSETYGGSGQMVERGANSSLLRREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YS2</accession>
    <name>Q39YS2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix-turn-helix transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0359</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512331.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0359"/>
    <dbReference type="EnsemblBacteria" id="ABB30602">
        <property type="protein sequence ID" value="ABB30602"/>
        <property type="gene ID" value="Gmet_0359"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0359"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_2_7"/>
    <dbReference type="OMA" id="HLTAHAW"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023187">
        <property type="entry name" value="Tscrpt_reg_MarR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12802">
        <property type="entry name" value="MarR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01117">
        <property type="entry name" value="HTH_MARR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="154" mass="17514" checksum="9EC9119596CBB031" modified="2005-11-22" version="1">MNLSDEKIGRSNLFYRLGLLTRHWRQVLDTDFQFAGLTDATWRPLLHLHLLGDGTRQKDLAASIGIEGPSLVRLLDTLIAKGLIERLEDVTDRRAKLLNLTPEGRVIVARIQETVTALENDLLSPFSDDEIARVAEFIERLESTVNEARRRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YT8</accession>
    <name>Q39YT8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30586.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512314.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0343"/>
    <dbReference type="EnsemblBacteria" id="ABB30586">
        <property type="protein sequence ID" value="ABB30586"/>
        <property type="gene ID" value="Gmet_0343"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0343"/>
    <dbReference type="HOGENOM" id="CLU_1903695_0_0_7"/>
    <dbReference type="OMA" id="FENGMGL"/>
    <dbReference type="OrthoDB" id="1615081at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30586.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="134" mass="15154" checksum="95C3649F37EBCA8B" modified="2012-10-31" version="2">MEEFTPMTAESVWEILVREGAEVFAREGRSDSYGAPRDFSFEVKALFPNGMGLHIVARQFNYRDPWEAAGRVNDMVDVSLLRDGSYSPFPKGYPWFQGTDQEEGIDEKGLREIIGCVKGLNPKVYLLQELTGDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YV2</accession>
    <name>Q39YV2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nitrate reductase (quinone)</fullName>
            <ecNumber evidence="7">1.7.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">narG-1</name>
        <name evidence="14" type="ordered locus">Gmet_0329</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinol + nitrate = a quinone + H2O + nitrite</text>
            <dbReference type="Rhea" id="RHEA:56144"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.7.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mo-bis(molybdopterin guanine dinucleotide)</name>
            <dbReference type="ChEBI" id="CHEBI:60539"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.7.5.1" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365654.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39YV2"/>
    <dbReference type="STRING" id="269799.Gmet_0329"/>
    <dbReference type="EnsemblBacteria" id="ABB30572">
        <property type="protein sequence ID" value="ABB30572"/>
        <property type="gene ID" value="Gmet_0329"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0329"/>
    <dbReference type="eggNOG" id="COG5013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_14_1_7"/>
    <dbReference type="OMA" id="FAFDWQR"/>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02776">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037943">
        <property type="entry name" value="MopB_CT_Nitrate-R-NarG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006468">
        <property type="entry name" value="NarG"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01580">
        <property type="entry name" value="narG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00932">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="28"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1191" mass="134343" checksum="21558D65616A8CB5" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YV4</accession>
    <name>Q39YV4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Menaquinol oxidoreductase complex Cbc4, cytochrome b subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cbcU-2</name>
        <name evidence="8" type="ordered locus">Gmet_0327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512299.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0327"/>
    <dbReference type="EnsemblBacteria" id="ABB30570">
        <property type="protein sequence ID" value="ABB30570"/>
        <property type="gene ID" value="Gmet_0327"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0327"/>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045348_3_0_7"/>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="417" mass="47049" checksum="1483569B3D190501" modified="2005-11-22" version="1">MVHGEAWTLKELFVYPNEYIYWTIQIVMYPFMTGLVAGAFVLSSLYHVFGIKQLKDIARFSLVFSFALLPVAMIPLQLHLQHPERGIEVMLTPHFTSAIAAFGIAFSTYGMIVASELWFVYRRHFVETALALREKRDKTIPERGRQLLFSALTLGAWDISEQALAKDERAVKIMATAGIPVACLLHGYAGFIFGSVKANALWTTPLMPFIFICSAVVSGIALCVLSYIVTMEVRKLMVAWRRKSDPSLPTPDEIRTVEMYEVTMTAKYLVLALLAALGLELLDLLFRDYAKFSSWEIVRSLIYGKDFVNVFVIQYGIGNLVPLALFLLPRLTVRRAVVATLLVLMGVFMMRWNLVIGGQAFSASFSGYMHYELPIIPHDIETFKEGLLGALLVGVLPFIFFWGLNKIFPVFKCEDTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YX2</accession>
    <name>Q39YX2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain pair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514019.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0307"/>
    <dbReference type="EnsemblBacteria" id="ABB30552">
        <property type="protein sequence ID" value="ABB30552"/>
        <property type="gene ID" value="Gmet_0307"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0307"/>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_12_3_7"/>
    <dbReference type="OMA" id="YCARLFE"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="16"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="87"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="16631" checksum="89727236E4889E76" modified="2005-11-22" version="1">MEALKKIRNTPVSEYMQREVASIEGSQTVAQAIQLIKTRKVASLVVLPRNEDDVYGILTVRDILGKVIDPGENIYRDIWNTQVHDIMTKPVYSIDPTMRVKYALRMMNRLGVRRLVVLRGNELAGIISEIEIFRAVEDLPAVAQVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z15</accession>
    <name>Q39Z15_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cysteine synthase</fullName>
            <ecNumber evidence="3">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysM</name>
        <name evidence="8" type="ordered locus">Gmet_0264</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513581.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0264"/>
    <dbReference type="EnsemblBacteria" id="ABB30509">
        <property type="protein sequence ID" value="ABB30509"/>
        <property type="gene ID" value="Gmet_0264"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0264"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_7"/>
    <dbReference type="OMA" id="GIRRWPE"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PALP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="5">
        <location>
            <begin position="180"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="308" mass="32937" checksum="FC4D6EC794C40D60" modified="2005-11-22" version="1">MEHTPFSLSGSIGSTPLVEIRKLNPNPKVRILAKLEGNNVGGSVKDRPALYMLAKAEAAGELSPERTILEPTSGNTGIAIAMLGAAKGYRVKLVMPACVSLERRAVLEAYGAELVLSPAEEATDGAIRLAHRILDEEPDRYYMPNQYANPNNPLAHYETTGPEIYRGTDGTVDFFVAGMGTGGTLMGVSRYFRETKPSVRIVGVEPRLGHKVQGLKNMQEAIVPAIYNPAALDLKLTVQDEPAFDTARDLAVREGLFVGMSSGAAMAGAIRVAKDAPAGSTIVVLLPDRGDRYLSTVLFRSVCGKCPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZA6</accession>
    <name>Q39ZA6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADH dehydrogenase I, M subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">nuoM-2</name>
        <name evidence="6" type="ordered locus">Gmet_0171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Membrane</location>
            <topology evidence="1 3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I subunit 4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512759.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0171"/>
    <dbReference type="EnsemblBacteria" id="ABB30418">
        <property type="protein sequence ID" value="ABB30418"/>
        <property type="gene ID" value="Gmet_0171"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0171"/>
    <dbReference type="eggNOG" id="COG1008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_4_4_7"/>
    <dbReference type="OMA" id="RIACSSV"/>
    <dbReference type="OrthoDB" id="535707at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010227">
        <property type="entry name" value="NADH_Q_OxRdtase_chainM/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43507">
        <property type="entry name" value="PTHR43507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01972">
        <property type="entry name" value="NDH_I_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="5">
        <location>
            <begin position="136"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="496" mass="53635" checksum="2AB59EF97ACC3E1A" modified="2005-11-22" version="1">MTDYPILTILIFLPLAGCLCLAPVWHCRTSARAVALGFAVAELALAAWLLVAATGMPAAPGAPTGYFLWEDAVWIERFGIRYLLGMDGISLLMVALTAFITVVAMAVSWRAVTERTALHYFLILLMESGLMGVFLALDLVLFYLFWEVMLIPMFFLIGIWGHGRRIYSAVKFFLYTLAGSLLMLLAIIGVYLIHGDATGIYTFTLPLLAKAPIAHAAAPWLFGAFLLAFAIKFPLFPVHTWLPDAHTDAPTAGSVILAALLLKTGAYGLVRFGYPLFPEAAKGFTPFISALAVVGILYASWVAYAQEDMKRMVAYSSVGHMGFVALGIASWSPVALSGSILQMVNHGVTTGALFALVGMLDERTDTREIAAYGGVWGKAPKLAFFFLLFAMTSAGLPGLNNFTGEFLILAGVFRTTPAAAAIAFIGIVLPLIYTVRLVQEVLFQTERRPLRLPDVTLREEALLAVLATIDVYIGVHPKPLLDILKVPVALLTGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZD3</accession>
    <name>Q39ZD3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512727.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0142"/>
    <dbReference type="EnsemblBacteria" id="ABB30391">
        <property type="protein sequence ID" value="ABB30391"/>
        <property type="gene ID" value="Gmet_0142"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0142"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017567_0_0_7"/>
    <dbReference type="OMA" id="TIWEIEP"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223640" evidence="1">
        <location>
            <begin position="28"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="413" mass="46316" checksum="B2ECFA6F4C0D776C" modified="2005-11-22" version="1">MKGLIVRYGMVAVVAVLGIAASLGLRAAPTEAAQKSKCISCHEKVTPGVVTQFLSGKMGKTLDCSTCHGSDHQTEKDVAKVKLPTPETCAQCHEKRVKEYREGKHALAWVSMKAMPMINHQPSSVGGGDLKGCSACHKVGEKPMADLTRYGTGACDSCHTRHSFSVKEARDPRACRTCHMGFDHPQWEMWQTSKHGTIWEIEPTTGRAPTCQTCHMPDGSHGVMTAWGFLALRVPEDDKEWWDNRVTILKAIGVLDEKGQPTERFEAVKAAKIARLTKEDFDKERKKMIDVCSKCHSRSYAEANLKAGDDIIREVDKIFADSIRTVKALYDDGILKKPADWKYAPDLLQFYEAKSAAEQELYLIFLEYRQRAFQGAFHANPDYMHWYGWAKVKEASARIKEDAERLRAEAKKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZJ8</accession>
    <name>Q39ZJ8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Gmet_0077</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514201.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0077"/>
    <dbReference type="EnsemblBacteria" id="ABB30326">
        <property type="protein sequence ID" value="ABB30326"/>
        <property type="gene ID" value="Gmet_0077"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0077"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_414912_0_0_7"/>
    <dbReference type="OMA" id="KSHDETH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004010">
        <property type="entry name" value="Double_Cache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033480">
        <property type="entry name" value="sCache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08269">
        <property type="entry name" value="dCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01049">
        <property type="entry name" value="Cache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="11">
        <location>
            <begin position="284"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="12">
        <location>
            <begin position="528"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="9">
        <location>
            <position position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB30326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="661" mass="72759" checksum="6055B70740FC64F0" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZK4</accession>
    <name>Q39ZK4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bifunctional glutamine synthetase adenylyltransferase/adenylyl-removing enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">ATP:glutamine synthetase adenylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">ATase</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="3">Glutamine synthetase adenylyl-L-tyrosine phosphorylase</fullName>
                <ecNumber evidence="3">2.7.7.89</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Adenylyl removase</fullName>
                <shortName evidence="3">AR</shortName>
                <shortName evidence="3">AT-N</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="3">Glutamine synthetase adenylyl transferase</fullName>
                <ecNumber evidence="3">2.7.7.42</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="3">Adenylyl transferase</fullName>
                <shortName evidence="3">AT</shortName>
                <shortName evidence="3">AT-C</shortName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">glnE</name>
        <name evidence="6" type="ordered locus">Gmet_0071</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[glutamine synthetase]-L-tyrosine + ATP = [glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18589"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="EC" id="2.7.7.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>[glutamine synthetase]-O(4)-(5'-adenylyl)-L-tyrosine + phosphate = [glutamine synthetase]-L-tyrosine + ADP</text>
            <dbReference type="Rhea" id="RHEA:43716"/>
            <dbReference type="Rhea" id="RHEA-COMP:10660"/>
            <dbReference type="Rhea" id="RHEA-COMP:10661"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:83624"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.7.89"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GlnE family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.89" evidence="3"/>
    <dbReference type="EC" id="2.7.7.42" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514195.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0071"/>
    <dbReference type="EnsemblBacteria" id="ABB30320">
        <property type="protein sequence ID" value="ABB30320"/>
        <property type="gene ID" value="Gmet_0071"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0071"/>
    <dbReference type="eggNOG" id="COG1391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006233_1_1_7"/>
    <dbReference type="OMA" id="EFMVQYA"/>
    <dbReference type="OrthoDB" id="427701at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008882">
        <property type="term" value="F:[glutamate-ammonia-ligase] adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047388">
        <property type="term" value="F:[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000820">
        <property type="term" value="P:regulation of glutamine family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00802">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023057">
        <property type="entry name" value="GlnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005190">
        <property type="entry name" value="GlnE_rpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30621">
        <property type="entry name" value="PTHR30621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03710">
        <property type="entry name" value="GlnE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GlnE" evidence="4">
        <location>
            <begin position="101"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="5">
        <location>
            <begin position="381"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="GlnE" evidence="4">
        <location>
            <begin position="639"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="domain" description="GlnD_UR_UTase" evidence="5">
        <location>
            <begin position="911"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl removase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Adenylyl transferase" evidence="3">
        <location>
            <begin position="540"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1063" mass="120097" checksum="485AB56256799564" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZM3</accession>
    <name>Q39ZM3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc-dependent peptidase, M16 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0052</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514176.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0052"/>
    <dbReference type="EnsemblBacteria" id="ABB30301">
        <property type="protein sequence ID" value="ABB30301"/>
        <property type="gene ID" value="Gmet_0052"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0052"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_3_3_7"/>
    <dbReference type="OMA" id="SEMTHVA"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="16"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="171"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="432" mass="47231" checksum="BEAFF7F37BF887BE" modified="2005-11-22" version="1">MTTITPSLTTLPNGLRVVAVEMPHLNSAEIAVYLRVGGRHDSREKAGLAHFLEHMLFRGTAEHPSSLELEADFEAIGGCINAATDAETTCYYTRVHPDHVAEGVRLLSVMLLSPLLTGLEIEKKIITEEALEDINEQGEEVNPDNLASRLLWPGHGIGMPTIGYLDTIAGFTEEDLRGHMARHYVPENAVVVAAGRVSVEEVFAAAGRAFASWSGPPAPVQESVSDVQDAPVSLFVKDSDSQVNLQLAFRSFPREDQRLAAARLIRRILTGGGCSRLHLNLRERLGIVYSVDAQLAAYDDTGCFAVELSTAPENLAVAVTEVLRETLRLATEPVGDEELDRVRQGYFFDLDYSRDSTFDMQVRYGWGELMGMVRSIEEDQAEAGAVDAAAVMATARELFAPARLNLVAVGPVKAAVKREIAGIVRRYEAEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEM0</accession>
    <name>J9JEM0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3647</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512818.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFR42791">
        <property type="protein sequence ID" value="AFR42791"/>
        <property type="gene ID" value="Gmet_3647"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3647"/>
    <dbReference type="HOGENOM" id="CLU_2934936_0_0_7"/>
    <dbReference type="OMA" id="QGCVLTK"/>
    <dbReference type="OrthoDB" id="2067404at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="60" mass="6293" checksum="A626CD276D74ABEC" modified="2012-10-31" version="1">MIRMMIIMGMLLMLQGCVLTKLVSVPMRVTGAVISIIPVAGNAVHDGIDSAADVVDDVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEN5</accession>
    <name>J9JEN5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hemin uptake protein HemP, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3611</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFR42829">
        <property type="protein sequence ID" value="AFR42829"/>
        <property type="gene ID" value="Gmet_3611"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3611"/>
    <dbReference type="eggNOG" id="COG4256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2915955_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019600">
        <property type="entry name" value="Hemin_uptake_protein_HemP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10636">
        <property type="entry name" value="hemP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="61" mass="6775" checksum="68FDE29A4AB94D26" modified="2012-10-31" version="1">MHTFQQTRTHINIQAGGNGAMPVKCITAAELMDGEIEIIIVHAGEQYRLRITANNKLILTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PP4</accession>
    <name>Q39PP4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Mobilization protein MobB, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_A3575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514717.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3575"/>
    <dbReference type="EnsemblBacteria" id="ABB33780">
        <property type="protein sequence ID" value="ABB33780"/>
        <property type="gene ID" value="Gmet_A3575"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3575"/>
    <dbReference type="HOGENOM" id="CLU_1978337_0_0_7"/>
    <dbReference type="OrthoDB" id="1752378at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="126" mass="13846" checksum="01B06A8F32EC4177" modified="2005-11-22" version="1">MKAKSGSERRNKSEMIHIRVTAEDLSRYTAKATASGVSVGELARRCLDGRATPSKTTIAAVADLRRAVGELRRFGGLQKYLMTRKEITPEEAQKNLGNIDIALDEIRRAAVAIQRQFAAEEGAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PP5</accession>
    <name>Q39PP5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Relaxase/mobilization nuclease domain protein MobA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_A3574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="4">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="4">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="4">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514718.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3574"/>
    <dbReference type="EnsemblBacteria" id="ABB33779">
        <property type="protein sequence ID" value="ABB33779"/>
        <property type="gene ID" value="Gmet_A3574"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3574"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_373754_0_0_7"/>
    <dbReference type="OMA" id="MPITFAD"/>
    <dbReference type="OrthoDB" id="1134905at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005094">
        <property type="entry name" value="Endonuclease_MobA/VirD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040677">
        <property type="entry name" value="LPD7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18821">
        <property type="entry name" value="LPD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03432">
        <property type="entry name" value="Relaxase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0614">Plasmid</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LPD7" evidence="2">
        <location>
            <begin position="455"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="743" mass="84359" checksum="03702D028EEAD113" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PR0</accession>
    <name>MNMG_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucose-inhibited division protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mnmG</name>
        <name evidence="1" type="synonym">gidA</name>
        <name type="ordered locus">Gmet_3559</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Heterotetramer of two MnmE and two MnmG subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513715.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39PR0"/>
    <dbReference type="SMR" id="Q39PR0"/>
    <dbReference type="STRING" id="269799.Gmet_3559"/>
    <dbReference type="EnsemblBacteria" id="ABB33764">
        <property type="protein sequence ID" value="ABB33764"/>
        <property type="gene ID" value="Gmet_3559"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3559"/>
    <dbReference type="eggNOG" id="COG0445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007831_2_2_7"/>
    <dbReference type="OMA" id="FRPGYAI"/>
    <dbReference type="OrthoDB" id="146811at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00129">
        <property type="entry name" value="MnmG_GidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004416">
        <property type="entry name" value="MnmG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026904">
        <property type="entry name" value="MnmG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044920">
        <property type="entry name" value="MnmG_C_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF0">
        <property type="entry name" value="PTHR11806:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13932">
        <property type="entry name" value="GIDA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00136">
        <property type="entry name" value="gidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01280">
        <property type="entry name" value="GIDA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000016603" description="tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG">
        <location>
            <begin position="1"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00129"/>
        </source>
    </evidence>
    <sequence length="624" mass="69062" checksum="DB17900871FD2952" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PR7</accession>
    <name>Q39PR7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3552</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513708.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3552"/>
    <dbReference type="EnsemblBacteria" id="ABB33757">
        <property type="protein sequence ID" value="ABB33757"/>
        <property type="gene ID" value="Gmet_3552"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3552"/>
    <dbReference type="HOGENOM" id="CLU_2069749_0_0_7"/>
    <dbReference type="OMA" id="TRKDINE"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223406" evidence="2">
        <location>
            <begin position="24"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="118" mass="13286" checksum="9880B9E15798FCF9" modified="2005-11-22" version="1">MKKTLLTLTACITLGAFAGIASAADYTIPSPSAELQKREDKAKEKVQKKEKAAKEKLAEKEKKVSDKQTDVKEQVEKKKAQATEKHEKVKSKVKQKKEKAKQMKEAGKKEVQDLKEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PU9</accession>
    <name>Q39PU9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Menaquinol oxidoreductase complex Cbc4, cytochrome b subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cbcU-1</name>
        <name evidence="8" type="ordered locus">Gmet_3520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513677.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3520"/>
    <dbReference type="EnsemblBacteria" id="ABB33725">
        <property type="protein sequence ID" value="ABB33725"/>
        <property type="gene ID" value="Gmet_3520"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3520"/>
    <dbReference type="eggNOG" id="COG4881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045348_3_0_7"/>
    <dbReference type="OMA" id="LMIVMYP"/>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="417" mass="47104" checksum="AE7A0E5F452078C3" modified="2005-11-22" version="1">MLHGEAWTVKELFVYPNEYIYWTIQIVMYPFLTGLVAGAFVLSSLYHVFGVTKLKEIARFSLVFSFALLPCAPMPLLLHLQQPQRNLNVLMTPHFTSAIAAFGIVFLTYGMIVASELWFVYRGYFVTTARELRLKPNRTLSETFLMGLYSILVMGAWDVSHHALEQDERAVKILAAVGIPVACFLHGYAGFIFGSVKANALWMTPLMPVIFICSAVVSGIALCILTYVITMELRKLIIAWRWKENPSLPSPGELGGVETQVVTMTSRYLIMFLILAITLELLDLIFRGYTAVKSWDILRSVIYGKDFTSIFILQYGLGNLVPFILFLMPGLTVRRAVVGTVLVLFGVFMMRWNVVIGGQAFSASFAGFMHYHMPIWPHDMETFKEGLFGALMVGSIPFALFWLLSRIFPIFDLKEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PX1</accession>
    <name>Q39PX1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Universal stress protein Usp</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">usp-3</name>
        <name evidence="2" type="ordered locus">Gmet_3498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513655.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3498"/>
    <dbReference type="EnsemblBacteria" id="ABB33703">
        <property type="protein sequence ID" value="ABB33703"/>
        <property type="gene ID" value="Gmet_3498"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3498"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_2_7"/>
    <dbReference type="OMA" id="MPCSILL"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="1">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="153" mass="17855" checksum="44A952B81204D7C6" modified="2005-11-22" version="1">MEDFRRILVVSRMTTYCQEAVHCGVSLARKYGAELFLIHAIHNPFGLEGWNLPVVSLEKEYEKITREAKADLDRILERERSNGLPVAELIRKGEPTKEILKAVEELKIDLLIMLSHEEWRLEHFLFGRSNEEIVRKMPCSVLLVKKEPQSVKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q90</accession>
    <name>Q39Q90_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system protein GspL, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gspL</name>
        <name evidence="3" type="ordered locus">Gmet_3372</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512598.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3372"/>
    <dbReference type="EnsemblBacteria" id="ABB33584">
        <property type="protein sequence ID" value="ABB33584"/>
        <property type="gene ID" value="Gmet_3372"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3372"/>
    <dbReference type="eggNOG" id="COG3297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_622225_0_0_7"/>
    <dbReference type="OMA" id="HDLAGAY"/>
    <dbReference type="OrthoDB" id="1099393at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025691">
        <property type="entry name" value="GspL_pp_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12693">
        <property type="entry name" value="GspL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="GspL_C" evidence="2">
        <location>
            <begin position="271"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="427" mass="45688" checksum="8AAF74887D268180" modified="2005-11-22" version="1">MIYLILEWTGAELVASRFLQRRGELLFQGADSRPAATEAELADALRELPPAGNDSRIALSLPLARLFMREMGLPIRDRKKLREVLPLELRGETALETDELAFAGLPLAGGAVLALWGRKRELAACISATAAAGVEPEVLSAAPLHWGELLPSQDHGTVALTDGSALALFRDREPLFFRALTEGEDCARTLALLEISKGITVDRTCRLGAPATAEGTPLPVEGSLAAAFGGDEGAARRYGSAWALATAMAQGDAVDFRAGDLAWTKGKEKALRRLRLPLALAALLLFLLGADASIRYLLVKRDLASLDASIGTIYREVFPGRKKGVDEAAEMRAELRKLGSSGGKSQVLETLNRLAMAKGDDILGLYEVEIDSGQVRLKGDARSTQAVNDFKNRLAAMLSPAEVGQITSKPDGTVTFTLRGTMKEGSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QG9</accession>
    <name>Q39QG9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">3-methylcrotonyl-CoA carboxylase, biotin-containing alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">mccA</name>
        <name evidence="10" type="ordered locus">Gmet_3292</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512516.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3292"/>
    <dbReference type="EnsemblBacteria" id="ABB33505">
        <property type="protein sequence ID" value="ABB33505"/>
        <property type="gene ID" value="Gmet_3292"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3292"/>
    <dbReference type="eggNOG" id="COG4770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_1_7"/>
    <dbReference type="OMA" id="IYYDPML"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="1"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="588"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="668" mass="71535" checksum="EEF2D5CBDBDD5CA1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QI4</accession>
    <name>Q39QI4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">DNA repair protein RadA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">radA</name>
        <name evidence="8" type="ordered locus">Gmet_3277</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.</text>
    </comment>
    <comment type="domain">
        <text evidence="5">The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the RecA family. RadA subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3277"/>
    <dbReference type="EnsemblBacteria" id="ABB33490">
        <property type="protein sequence ID" value="ABB33490"/>
        <property type="gene ID" value="Gmet_3277"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3277"/>
    <dbReference type="eggNOG" id="COG1066">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018264_0_1_7"/>
    <dbReference type="OMA" id="FELMRLA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01121">
        <property type="entry name" value="Sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01498">
        <property type="entry name" value="RadA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004504">
        <property type="entry name" value="DNA_repair_RadA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041166">
        <property type="entry name" value="Rubredoxin_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18073">
        <property type="entry name" value="Rubredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00416">
        <property type="entry name" value="sms"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RECA_2" evidence="7">
        <location>
            <begin position="62"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Lon-protease-like" evidence="5">
        <location>
            <begin position="347"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="RadA KNRFG motif" evidence="5">
        <location>
            <begin position="248"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="91"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="449" mass="47132" checksum="42A1460CE54C653D" modified="2005-11-22" version="1">MKTMTLYVCQNCGYQSAKWLGKCPDCSAWNSLVEEVRGKGKGPSAPLSGVAPVPICDVAGEAEERLPCGISEFDRVLGGGLVAGSVILIGGDPGIGKSTLLLQVMDHLARTVGPVLYVSGEESARQARLRGERLGIRAKELLILAETALETVLAQIGAVAPRAVVIDSIQTMYAPGLESAPGSVSQVRECAGRLMVAAKRSAIPTFIVGHVTKDGSIAGPRVLEHMVDTVLYFEGDRGHAFRILRAVKNRFGSTNEIGVFEMKEGGLCEVRNPSEIFLSERPLGVSGSAVVTTIEGSRPLLVELQALVTPSSLGVPRRTTLGVDANRLALLVAVLDKKVGLHMAGQDIFLNAAGGARVSEPAADLGMVAALASSHLDKVIDPQTVVVGEVGLAGEVRAITQPETRVREAAKLGFTRAVIPAGSLKQVTAVEGMEVIGVKSVEEALDRLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QM7</accession>
    <name>HEM3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Porphobilinogen deaminase</fullName>
            <shortName evidence="1">PBG</shortName>
            <ecNumber evidence="1">2.5.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hydroxymethylbilane synthase</fullName>
            <shortName evidence="1">HMBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pre-uroporphyrinogen synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemC</name>
        <name type="ordered locus">Gmet_3234</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57845"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="EC" id="2.5.1.61"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>dipyrromethane</name>
            <dbReference type="ChEBI" id="CHEBI:60342"/>
        </cofactor>
        <text evidence="1">Binds 1 dipyrromethane group covalently.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 2/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The porphobilinogen subunits are added to the dipyrromethane group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HMBS family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.61" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512673.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QM7"/>
    <dbReference type="SMR" id="Q39QM7"/>
    <dbReference type="STRING" id="269799.Gmet_3234"/>
    <dbReference type="EnsemblBacteria" id="ABB33447">
        <property type="protein sequence ID" value="ABB33447"/>
        <property type="gene ID" value="Gmet_3234"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3234"/>
    <dbReference type="eggNOG" id="COG0181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019704_0_2_7"/>
    <dbReference type="OMA" id="LWQANHI"/>
    <dbReference type="OrthoDB" id="1450400at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00319"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004418">
        <property type="term" value="F:hydroxymethylbilane synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018160">
        <property type="term" value="P:peptidyl-pyrromethane cofactor linkage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00260">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000860">
        <property type="entry name" value="HemC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022419">
        <property type="entry name" value="Porphobilin_deaminase_cofac_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022417">
        <property type="entry name" value="Porphobilin_deaminase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022418">
        <property type="entry name" value="Porphobilinogen_deaminase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036803">
        <property type="entry name" value="Porphobilinogen_deaminase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11557">
        <property type="entry name" value="PTHR11557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01379">
        <property type="entry name" value="Porphobil_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03900">
        <property type="entry name" value="Porphobil_deamC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001438">
        <property type="entry name" value="4pyrrol_synth_OHMeBilane_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00151">
        <property type="entry name" value="PORPHBDMNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54782">
        <property type="entry name" value="SSF54782"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00212">
        <property type="entry name" value="hemC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00533">
        <property type="entry name" value="PORPHOBILINOGEN_DEAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000304243" description="Porphobilinogen deaminase">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="modified residue" description="S-(dipyrrolylmethanemethyl)cysteine" evidence="1">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00260"/>
        </source>
    </evidence>
    <sequence length="318" mass="34648" checksum="5311BCF7CE6FF396" modified="2005-11-22" version="1">MAPKQLRIGTRASQLALWQANWVKGELEKRYPGMAVELVKIKTMGDKILDVPLAQVGGKGLFVKEIEEAMLRGEIDIAVHSMKDVPTEFPEGLGLYCITEREDPRDAVISRGVKFADLPQGARIGTSALRRQAQILKVRPDLQMVVIRGNVETRIRKLTDENLDAVILAAAGLNRLGFADQVSEYLPVELSLPAIGQGALGIECRLDDETIKDTIAFFNHPDTAHAVRAERALLWRCEGGCQVPIAAHGQVSGDTLTLTGFVASVDGTRSVKDTISGPVTECEKLGIALAEKLLADGAHEILAEVYQREVAREKEIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QN1</accession>
    <name>Q39QN1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">trxA</name>
        <name evidence="7" type="ordered locus">Gmet_3230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thioredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512669.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3230"/>
    <dbReference type="EnsemblBacteria" id="ABB33443">
        <property type="protein sequence ID" value="ABB33443"/>
        <property type="gene ID" value="Gmet_3230"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3230"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_2_7"/>
    <dbReference type="OMA" id="QVGVAPK"/>
    <dbReference type="OrthoDB" id="1630944at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="34"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="109" mass="11631" checksum="BAC254E0F94BA9B7" modified="2005-11-22" version="1">MASEKVLTFSDDNFDTDVLKATVPVLVDFWATWCAPCKAIAPVIDAIADEYDGKVKVGKVNVDDNPGTPGKYGVRGIPTVILFKDGKVVDQVVGAVPKAQLEALIKKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QS0</accession>
    <name>Q39QS0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain iron-sulfur cluster-binding oxidoreductase, DUF2344-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512629.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3191"/>
    <dbReference type="EnsemblBacteria" id="ABB33404">
        <property type="protein sequence ID" value="ABB33404"/>
        <property type="gene ID" value="Gmet_3191"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3191"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011543_2_1_7"/>
    <dbReference type="OMA" id="WYTTRER"/>
    <dbReference type="OrthoDB" id="970297at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023862">
        <property type="entry name" value="CHP03960_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018768">
        <property type="entry name" value="DUF2344"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045784">
        <property type="entry name" value="Radical_SAM_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10105">
        <property type="entry name" value="DUF2344"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19864">
        <property type="entry name" value="Radical_SAM_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03960">
        <property type="entry name" value="rSAM_fuse_unch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03936">
        <property type="entry name" value="sam_1_link_chp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="247"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="842" mass="94087" checksum="3FDFAF9D507CD87E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QX6</accession>
    <name>Q39QX6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514310.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3135"/>
    <dbReference type="EnsemblBacteria" id="ABB33348">
        <property type="protein sequence ID" value="ABB33348"/>
        <property type="gene ID" value="Gmet_3135"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3135"/>
    <dbReference type="HOGENOM" id="CLU_1394583_0_0_7"/>
    <dbReference type="OMA" id="CENGRYD"/>
    <dbReference type="OrthoDB" id="2142095at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="179" mass="20939" checksum="36487785544E2A8B" modified="2005-11-22" version="1">MNIESTYSYTYQDQLHKSYKDFIMQCAPFSYFITLTFRNRQSEDESKRQINFLLHLLKQKVLGRKSDGEYLNGFCAFEKHRSFANNELHCHILLCSHDKLDCEGKKPFSEHFYECLGKVNVQYGVLHGKDIPQVKAFAKNCCDITVIYDLDGLVSYFTKTFERNLNLDAFQPIGKYGIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R06</accession>
    <name>Q39R06_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514279.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3104"/>
    <dbReference type="EnsemblBacteria" id="ABB33318">
        <property type="protein sequence ID" value="ABB33318"/>
        <property type="gene ID" value="Gmet_3104"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3104"/>
    <dbReference type="eggNOG" id="ENOG5032Y5R">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145226_2_0_7"/>
    <dbReference type="OMA" id="NIDSAVF"/>
    <dbReference type="OrthoDB" id="1943154at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013367">
        <property type="entry name" value="Flagellar_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12611">
        <property type="entry name" value="Flagellar_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02530">
        <property type="entry name" value="flg_new"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="129" mass="13828" checksum="B84FB3C204B8DCE3" modified="2005-11-22" version="1">MIDKIYFPEPLPINPGQKPAQPQPAKQGGAQPPAFAKILDGKMPAQGVKFSQHAQERLRARGISLNEADMKRLEGAVDSVAQKGGRESLIMLGDAALVVSVKNRTVITAMDRGSMQGNVFTNIDSAVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R30</accession>
    <name>Q39R30_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin/NifU-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513639.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3080"/>
    <dbReference type="EnsemblBacteria" id="ABB33294">
        <property type="protein sequence ID" value="ABB33294"/>
        <property type="gene ID" value="Gmet_3080"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3080"/>
    <dbReference type="eggNOG" id="COG0694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060555_4_3_7"/>
    <dbReference type="OMA" id="CSVNQMT"/>
    <dbReference type="OrthoDB" id="2010888at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU" evidence="1">
        <location>
            <begin position="5"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="74" mass="7963" checksum="15F2B11A29CD0A44" modified="2005-11-22" version="1">MLEEVKKVLDTVRPALQADGGDVELVEVTEDGVVKVKLVGACGHCPMSTMTLKMGIERTLKEKVPGVKEVISVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R63</accession>
    <name>Q39R63_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Endonuclease, TnsA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513606.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3046"/>
    <dbReference type="EnsemblBacteria" id="ABB33261">
        <property type="protein sequence ID" value="ABB33261"/>
        <property type="gene ID" value="Gmet_3046"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3046"/>
    <dbReference type="eggNOG" id="ENOG50332IR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100949_1_1_7"/>
    <dbReference type="OMA" id="SAINGRC"/>
    <dbReference type="OrthoDB" id="2001051at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014832">
        <property type="entry name" value="TnsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014833">
        <property type="entry name" value="TnsA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08721">
        <property type="entry name" value="Tn7_Tnp_TnsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08722">
        <property type="entry name" value="Tn7_Tnp_TnsA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tn7_Tnp_TnsA_N" evidence="2">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tn7_Tnp_TnsA_C" evidence="1">
        <location>
            <begin position="124"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="219" mass="25175" checksum="5BD830A67D507783" modified="2005-11-22" version="1">MPVRKIPKTYRSISGRFPSAINGRCIGYESKLERDYYLRLEFDQTIASYEEQPIRLSGSVDGKEVSYTPDCLVKFLDGKPPRIVEVKSQEELDKKAEDLERRFSLARNHVEGQGGEFVIINEKDIYDDALANYRLIYRFVKPPPNIETKRKLIIGILEHAGPLPLRDLLKSLGEDRIAQAHFTRAIWHMLYTREIEADLSKPISHSTILRISNGTENLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R68</accession>
    <name>Q39R68_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD-dependent pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3041</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513601.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3041"/>
    <dbReference type="DNASU" id="3741237"/>
    <dbReference type="EnsemblBacteria" id="ABB33256">
        <property type="protein sequence ID" value="ABB33256"/>
        <property type="gene ID" value="Gmet_3041"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3041"/>
    <dbReference type="eggNOG" id="COG1252">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021377_7_1_7"/>
    <dbReference type="OMA" id="DHCIFLD"/>
    <dbReference type="OrthoDB" id="403436at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006116">
        <property type="term" value="P:NADH oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="PTHR43706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="363"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="413" mass="45859" checksum="368B13D312264DE2" modified="2005-11-22" version="1">MKRVVIIGMGFGGIRAARVLAGKGLDVVLVDRNNYHLFQPLLYQVGTAGLEQESIAYPVRAMAREWRGTRFHLAEVAGVDFPAREVVTGNGRIPYDYLIIGAGSVTNYFGLESVERHAFDLKELVDGERLRNHILTAFERAVVEPDPAKRRALMTFVIVGGGPTGVEFAGALMELVRYVLAKDYPELSVQAARVVLVEAFDRLLAAMPQELQVYTLEKLRAMGVEVLFNARVVDAEPERVILHDGAIIPAHTLFWSAGVKAAPLAATLGVTPKPGGRIPVEPDLTLAGHPEVYVIGDMAHLEQDGAALPMVAPVAMQMGTYAGEAIVAREKGETPKPFRYRDRGSMATIGRSAAVACAFGMKFRGFSAWLVWLLLHLYYLIGFRNRIVVMLNWIWYYWFHERQVRLITERVEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-17" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R93</accession>
    <name>CRCB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative fluoride ion transporter CrcB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">crcB</name>
        <name type="ordered locus">Gmet_3016</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Important for reducing fluoride concentration in the cell, thus reducing its toxicity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CrcB (TC 9.B.71) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514330.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39R93"/>
    <dbReference type="SMR" id="Q39R93"/>
    <dbReference type="STRING" id="269799.Gmet_3016"/>
    <dbReference type="EnsemblBacteria" id="ABB33231">
        <property type="protein sequence ID" value="ABB33231"/>
        <property type="gene ID" value="Gmet_3016"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3016"/>
    <dbReference type="eggNOG" id="COG0239">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114342_2_3_7"/>
    <dbReference type="OMA" id="FLMFESF"/>
    <dbReference type="OrthoDB" id="1942863at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00454">
        <property type="entry name" value="CrcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="CrcB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="PTHR28259"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00494">
        <property type="entry name" value="crcB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000252885" description="Putative fluoride ion transporter CrcB">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00454"/>
        </source>
    </evidence>
    <sequence length="124" mass="13417" checksum="2E8C2D9F9EDE5B37" modified="2005-11-22" version="1">MLTIVAIALFGALGCLARYLLAGWVYAFVGRGFPYGTLTVNVVGAFLIGLIMEFSLRTTLIPQELRIGLTIGFLGGLTTFSTFSYETFRLLEDGEFITAAVNVLASVLVCLACTWLGIMTARHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R94</accession>
    <name>Q39R94_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514329.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3015"/>
    <dbReference type="EnsemblBacteria" id="ABB33230">
        <property type="protein sequence ID" value="ABB33230"/>
        <property type="gene ID" value="Gmet_3015"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3015"/>
    <dbReference type="eggNOG" id="ENOG502ZW7Z">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157159_0_0_7"/>
    <dbReference type="OMA" id="HREAKDW"/>
    <dbReference type="OrthoDB" id="2027075at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027843">
        <property type="entry name" value="DUF4440"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14534">
        <property type="entry name" value="DUF4440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4440" evidence="1">
        <location>
            <begin position="23"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="14122" checksum="748725367E4505F1" modified="2005-11-22" version="1">MRAPLVALLLLALAGCAREDRSIEEVLRQRERALATADVARYASLISPAYRDKGIDARTKRAEIAKTLAAFGPVSYRSLSRAIAVNGDNATVNSRYAMKVTTAGKPLELSGEETILLHREAKDWKIVGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R99</accession>
    <name>Q39R99_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxal-5'-phosphate-dependent chorismate-binding enzyme, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514323.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3010"/>
    <dbReference type="EnsemblBacteria" id="ABB33225">
        <property type="protein sequence ID" value="ABB33225"/>
        <property type="gene ID" value="Gmet_3010"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3010"/>
    <dbReference type="eggNOG" id="COG0115">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_6_2_7"/>
    <dbReference type="OMA" id="KNAHKER"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009396">
        <property type="term" value="P:folic acid-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005802">
        <property type="entry name" value="ADC_synth_comp_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="SSF56752"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00553">
        <property type="entry name" value="pabB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate_bind" evidence="1">
        <location>
            <begin position="118"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="586" mass="64545" checksum="0369057F19FBE716" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RB6</accession>
    <name>Q39RB6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histidine triad (HIT) family hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514484.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2993"/>
    <dbReference type="EnsemblBacteria" id="ABB33208">
        <property type="protein sequence ID" value="ABB33208"/>
        <property type="gene ID" value="Gmet_2993"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2993"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123330_1_1_7"/>
    <dbReference type="OMA" id="NYPWFIL"/>
    <dbReference type="OrthoDB" id="1598286at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026026">
        <property type="entry name" value="HIT_Hint"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000714">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="138" mass="16213" checksum="A1E38BFBF2F16212" modified="2005-11-22" version="1">MSTCPMCTKWHDEPPLRIAELEHTLVMLNRDQFFPGYTFVFTKEHVTELFHLDRDIRQGIMDEVTAVAAALYTIFRPAKMNYELLGNMVPHMHWHLVPRFGTDPLWPRPIWSEPHGEVILADAEYAGRIEQIRKQLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RI8</accession>
    <name>Q39RI8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycoside hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366121.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2918"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33136">
        <property type="protein sequence ID" value="ABB33136"/>
        <property type="gene ID" value="Gmet_2918"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2918"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005647_0_0_7"/>
    <dbReference type="OMA" id="AFWLMEG"/>
    <dbReference type="OrthoDB" id="76786at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="2">
        <location>
            <begin position="328"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1181" mass="131907" checksum="0DB57B8A44C62252" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RI9</accession>
    <name>Q39RI9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512853.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2917"/>
    <dbReference type="EnsemblBacteria" id="ABB33135">
        <property type="protein sequence ID" value="ABB33135"/>
        <property type="gene ID" value="Gmet_2917"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2917"/>
    <dbReference type="eggNOG" id="COG3228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063037_0_1_7"/>
    <dbReference type="OMA" id="EHSGEAW"/>
    <dbReference type="OrthoDB" id="1806453at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd20169">
        <property type="entry name" value="Peptidase_M90_mtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010384">
        <property type="entry name" value="MtfA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042252">
        <property type="entry name" value="MtfA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30164">
        <property type="entry name" value="PTHR30164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06167">
        <property type="entry name" value="Peptidase_M90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="255" mass="29450" checksum="ED6A41013DD6F26D" modified="2005-11-22" version="1">MGFFARLRRKRLACREFPSAWLGIIERNVPFYRMLPPEDRQELLGHVQIFLAEKHFEGCGGAEVTDEVRVTVAALASILLLHRATDYYPLLSSIVIYPDEYVGERRRWDEAGVVTEGPETRIGESWEQGTVVLSWKDVLLDAEAPDDAFNVVFHEFAHQLDQEEGITDNEGFLPGLPVEDRWREVFEGEFERLLADDEAGRWTLLDPYGAESPAEFFAVATETFFEMPGEMRRQHPELYEVLGLYYRQDPASWSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RK9</accession>
    <name>Q39RK9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NHL repeat domain lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512833.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2897"/>
    <dbReference type="EnsemblBacteria" id="ABB33115">
        <property type="protein sequence ID" value="ABB33115"/>
        <property type="gene ID" value="Gmet_2897"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2897"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008645_8_0_7"/>
    <dbReference type="OMA" id="ERPRIEW"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01436">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223180" evidence="3">
        <location>
            <begin position="22"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="115"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="202"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="252"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="363" mass="39711" checksum="DEACE5AAB10D2157" modified="2005-11-22" version="1">MKTIRSIGRFAVLAAMAALFAGCAGQQVKSEQRFFWPPLPERPRIEWLNAYSSQNDFPKSATEKFLTTIIGEEEGISLSKPITVRSDGRGKVYVGDPGAPGVYVFDFVNNIMRPFGKAEAEARIEQPVGIAIDENGRIYVSDTKKAAIMVFHQDETPAALINLKGMVEKIGDIAYDRIGKHLLALDVRGHKVLVLSLRGELLSSFGNRGTKPGEFNFPSALTVNNKGEIIVADAMNARIQIFSSDGKFLRMFGQRGDSPGTLQLIKGVAVDSDDNIYVTDGKGHKFEIFSTTGDYLLTVGGAFSALTTGKTAPGGFVIPQGIDIDKDNMIYVVDQLNRRFQVFRYISDSYLKANPIPGYTPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RP5</accession>
    <name>Q39RP5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA small subunit methyltransferase I</fullName>
            <ecNumber evidence="6">2.1.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">16S rRNA 2'-O-ribose C1402 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">rRNA (cytidine-2'-O-)-methyltransferase RsmI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">rsmI</name>
        <name evidence="8" type="ordered locus">Gmet_2861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>cytidine(1402) in 16S rRNA + S-adenosyl-L-methionine = 2'-O-methylcytidine(1402) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42924"/>
            <dbReference type="Rhea" id="RHEA-COMP:10285"/>
            <dbReference type="Rhea" id="RHEA-COMP:10286"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.198"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the methyltransferase superfamily. RsmI family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.198" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514592.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2861"/>
    <dbReference type="EnsemblBacteria" id="ABB33079">
        <property type="protein sequence ID" value="ABB33079"/>
        <property type="gene ID" value="Gmet_2861"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2861"/>
    <dbReference type="eggNOG" id="COG0313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044779_2_0_7"/>
    <dbReference type="OMA" id="RTMVFFE"/>
    <dbReference type="OrthoDB" id="1059309at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070677">
        <property type="term" value="F:rRNA (cytosine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000453">
        <property type="term" value="P:enzyme-directed rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11648">
        <property type="entry name" value="RsmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01877">
        <property type="entry name" value="16SrRNA_methyltr_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008189">
        <property type="entry name" value="rRNA_ssu_MeTfrase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46111">
        <property type="entry name" value="PTHR46111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005917">
        <property type="entry name" value="MTase_YraL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00096">
        <property type="entry name" value="TIGR00096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="7">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="282" mass="30791" checksum="6255B2110C7CB400" modified="2005-11-22" version="1">MKTPGTLYIVATPIGNLEDITFRAVRILKEVDLIAAEDTRHTRKLLTHFGISKPLTSYFDHNKHLKGDVILARLRDGASVALVSDAGTPCVADPGYQLVRDSIAEGIVVVPIPGASAAVAALSAAGLPTDSFTFIGFLPSRQGKRHQQLSSLKDEPRVLIFYEAPNRLMTTLRDMRDLWGERKIVVARELTKVYEEFVRGDTSAVIAQFADRQIKGEVVILVTPAEDSTQEGASAESLDEVLRRYLFVEGLSLKDAVKRASVDLGLARSLVYSEALRISSGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RR2</accession>
    <name>RS6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsF</name>
        <name type="ordered locus">Gmet_2844</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds together with S18 to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514572.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RR2"/>
    <dbReference type="SMR" id="Q39RR2"/>
    <dbReference type="STRING" id="269799.Gmet_2844"/>
    <dbReference type="EnsemblBacteria" id="ABB33062">
        <property type="protein sequence ID" value="ABB33062"/>
        <property type="gene ID" value="Gmet_2844"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2844"/>
    <dbReference type="eggNOG" id="COG0360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113441_5_3_7"/>
    <dbReference type="OMA" id="ITEASPM"/>
    <dbReference type="OrthoDB" id="1776954at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00473">
        <property type="entry name" value="bS6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00360">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000529">
        <property type="entry name" value="Ribosomal_S6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020814">
        <property type="entry name" value="Ribosomal_S6_plastid/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035980">
        <property type="entry name" value="Ribosomal_S6_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21011">
        <property type="entry name" value="PTHR21011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01250">
        <property type="entry name" value="Ribosomal_S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54995">
        <property type="entry name" value="SSF54995"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00166">
        <property type="entry name" value="S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000229543" description="30S ribosomal protein S6">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="118" mass="13230" checksum="54776F164B1EBE3A" modified="2005-11-22" version="1">MVRKYETVVIVQPDLGDDELKGLNAKVTDIIATMKGDLHRLEDWGVRKLAYPINKSARGRYYYVRFDGDAALIAELERRLRLDDKVLRYQSVKIEKETAAPAAKVAPVETAPAAEAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RT9</accession>
    <name>Q39RT9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513987.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2817"/>
    <dbReference type="EnsemblBacteria" id="ABB33035">
        <property type="protein sequence ID" value="ABB33035"/>
        <property type="gene ID" value="Gmet_2817"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2817"/>
    <dbReference type="eggNOG" id="COG2206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_1_7"/>
    <dbReference type="OMA" id="MRVMAIQ"/>
    <dbReference type="OrthoDB" id="1094814at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="181"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="372" mass="41214" checksum="8979A907F8744BEF" modified="2005-11-22" version="1">MNRSALEPLRNAVRHLVTAVSSAALYSFDHQQVTRLRAVTLDNLTTTLQEEPDISLVIIGDELLAGGVSLDTGLYVGRFVEMLRARGIGHIRFLQGITGEELSSLAASLGGGQKGGEIRSTEHIRLGRVEVRFNRSGEGDEKDPLADFTTEEVTRITELYEDVARNRKLQAAGIADVVGGIITALREQARPLMALAPLRDLDEYTFAHSVNVCILNLAQAMSLGIDGPLLQEIGIAGLLHDIGKMFVPREILTKPAQLTEDEWRIMRRHPHQGARCLIETPGVPHLAAVAAFEHHMKHDFSGYPEVPPGWSQSLVSEMTSISDFFDALRTRRAYSDSVELRQIAGMLLDRRGREFHPLLTRNFLLILSRMMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RW8</accession>
    <name>Q39RW8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2788</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511674.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2788"/>
    <dbReference type="EnsemblBacteria" id="ABB33006">
        <property type="protein sequence ID" value="ABB33006"/>
        <property type="gene ID" value="Gmet_2788"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2788"/>
    <dbReference type="eggNOG" id="COG0834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_69_7"/>
    <dbReference type="OMA" id="FFILMEN"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001638">
        <property type="entry name" value="Solute-binding_3/MltF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00497">
        <property type="entry name" value="SBP_bac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00062">
        <property type="entry name" value="PBPb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223312" description="Histidine kinase" evidence="7">
        <location>
            <begin position="28"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="357"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="300"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="576" mass="64143" checksum="244EB0459538BB46" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RY0</accession>
    <name>Q39RY0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">UDP-N-2, O-3-di-(3-hydroxyacyl)glucosamine/UDP-N-2, N-3-di-(3-hydroxyacyl)glucosediamine pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lpxH</name>
        <name evidence="11" type="ordered locus">Gmet_2776</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511685.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2776"/>
    <dbReference type="EnsemblBacteria" id="ABB32994">
        <property type="protein sequence ID" value="ABB32994"/>
        <property type="gene ID" value="Gmet_2776"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2776"/>
    <dbReference type="eggNOG" id="COG2908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074586_1_0_7"/>
    <dbReference type="OMA" id="FDFWFEY"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016462">
        <property type="term" value="F:pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043461">
        <property type="entry name" value="LpxH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010138">
        <property type="entry name" value="UDP-diacylglucosamine_Hdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990">
        <property type="entry name" value="PTHR34990"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34990:SF1">
        <property type="entry name" value="PTHR34990:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="10">
        <location>
            <begin position="1"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="246" mass="28461" checksum="B27A43C945025B6E" modified="2005-11-22" version="1">MRAIFIADAHLRHEGDENYRLLVEFLTELRGTVDTLFILGDLFEFWIGYETVPFTHYLPILKKLQELAENGTEIVYLEGNHDFHMGPFFTKTLGARVHPGPALVTIEGKQVYLCHGDEVNSRDYSYRLLRFILHSSLVRAATRVVPPSVASRIAERMSRGSRKNHGRRQHRWDYPALLREFAARRFREGCDVVVSGHFHIPFLDEADGKVLLSLGDWLTHYTYGEWRDGVVSLRRYRYRGPGTGDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S02</accession>
    <name>Q39S02_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2754</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511705.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2754"/>
    <dbReference type="EnsemblBacteria" id="ABB32972">
        <property type="protein sequence ID" value="ABB32972"/>
        <property type="gene ID" value="Gmet_2754"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2754"/>
    <dbReference type="eggNOG" id="ENOG503324C">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115764_0_0_7"/>
    <dbReference type="OMA" id="LMIHHHA"/>
    <dbReference type="OrthoDB" id="1649481at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="163" mass="19100" checksum="24CF2E20C5D363B9" modified="2005-11-22" version="1">MSAGQDLGSFVAGLLETIKSESLEWQKKHNDDLNKLKRDKDLADVKLRHEIEELQTRFEEHKVRVQIEEQHKTKQFSEFLQSIDETKSKILEQFPSMSKPIALMIHHHATELLKQAWHSPDTRDKLISQNKFTQLMLTITEELIEGNRQKSLPERTLKLISMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SA7</accession>
    <name>Q39SA7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2649</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511813.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2649"/>
    <dbReference type="EnsemblBacteria" id="ABB32867">
        <property type="protein sequence ID" value="ABB32867"/>
        <property type="gene ID" value="Gmet_2649"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2649"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_2_8_7"/>
    <dbReference type="OMA" id="RMMALEV"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="126" mass="14285" checksum="8C083744952DE4D7" modified="2005-11-22" version="1">MFKRIDHVEIIPRDFERAIGFYTEVLGFKVRQRLKVEAPPLEGIAYLELGDTVIELMQVRDATPAVVNPWQTGYRMMALEVEDMDRAVAYLAGKGVAITWGPVTLGTSKRAEIQDADGFSIELRQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SC1</accession>
    <name>Q39SC1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thiol reductant ABC exporter, ATP-binding protein CydD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cydD</name>
        <name evidence="10" type="ordered locus">Gmet_2634</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511827.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2634"/>
    <dbReference type="EnsemblBacteria" id="ABB32853">
        <property type="protein sequence ID" value="ABB32853"/>
        <property type="gene ID" value="Gmet_2634"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2634"/>
    <dbReference type="eggNOG" id="COG4988">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_9_7"/>
    <dbReference type="OMA" id="FPLNWAA"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042883">
        <property type="term" value="P:cysteine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014216">
        <property type="entry name" value="ABC_transptr_CydD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02857">
        <property type="entry name" value="CydD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="9">
        <location>
            <begin position="27"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="341"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="374"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="572" mass="60494" checksum="78E0BB4904F69946" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SC9</accession>
    <name>Q39SC9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome p460, contains 1 heme-binding site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511835.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2626"/>
    <dbReference type="EnsemblBacteria" id="ABB32845">
        <property type="protein sequence ID" value="ABB32845"/>
        <property type="gene ID" value="Gmet_2626"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2626"/>
    <dbReference type="eggNOG" id="ENOG5030GRY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106310_2_0_7"/>
    <dbReference type="OMA" id="HDYVFTR"/>
    <dbReference type="OrthoDB" id="1212262at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032033">
        <property type="entry name" value="Cytochrome_P460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038142">
        <property type="entry name" value="Cytochrome_P460_sp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16694">
        <property type="entry name" value="Cytochrome_P460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome_P460" evidence="1">
        <location>
            <begin position="33"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="163" mass="17809" checksum="3E9FC290E3060031" modified="2005-11-22" version="1">MKTMIGALIIMLLPLIALGKDRPVAPNGISLIEGYRNWQVIAPSYRDDKGHIRVIFGNDTAMKAMKEGTRPFPDGTIMAKVAWTAVKHPKFPVATIPDGFAQVEFMVKDAAKYKATGGWGFARFVGNGLKPYGRDASFVQECFGCHTPVKGNDYVFTGFAPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SH4</accession>
    <name>Q39SH4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Small-conductance mechanosensitive ion channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mscS-2</name>
        <name evidence="8" type="ordered locus">Gmet_2581</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513452.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2581"/>
    <dbReference type="EnsemblBacteria" id="ABB32800">
        <property type="protein sequence ID" value="ABB32800"/>
        <property type="gene ID" value="Gmet_2581"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2581"/>
    <dbReference type="eggNOG" id="COG3264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037945_4_2_7"/>
    <dbReference type="OMA" id="FMYFDKP"/>
    <dbReference type="OrthoDB" id="1903165at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011066">
        <property type="entry name" value="MscS_channel_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011014">
        <property type="entry name" value="MscS_channel_TM-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82689">
        <property type="entry name" value="SSF82689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82861">
        <property type="entry name" value="SSF82861"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="298" mass="33060" checksum="4B996B78A1755FFA" modified="2005-11-22" version="1">METVRDILIQIKQFLEVPLVKLGSAPVTLWTIIQLVVLVGLLFYLSGKLRGWIVDQFLTRTRMELGARQATGSIIRYTIIAIGFIIILQTAGIDLTTLNVLAGAVGIGVGFGLQNIVNNLVCGILILFERPIKVGDRIVVGNVEGDVVHIGGRSTTVVTNDNITIIVPNSKFITENVVNWSHNERKVRFRIPVSVAYESDVQQVERLLLDVAAANPDVLEKPAPGVRLMEFGDNGLNFELRVWSTTLIHRRGLLTSNLNYAVYRAFVEHGIEIPFPRRDVRILREARQAEPFDGNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ST0</accession>
    <name>Q39ST0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Fibronectin type III repeat, DUF2341 repeat and LamG-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512431.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2469"/>
    <dbReference type="EnsemblBacteria" id="ABB32694">
        <property type="protein sequence ID" value="ABB32694"/>
        <property type="gene ID" value="Gmet_2469"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2469"/>
    <dbReference type="eggNOG" id="COG1520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5306">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_224787_0_0_7"/>
    <dbReference type="OMA" id="PYWIESK"/>
    <dbReference type="OrthoDB" id="91173at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013431">
        <property type="entry name" value="Delta_60_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018765">
        <property type="entry name" value="DUF2341"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010620">
        <property type="entry name" value="SBBP_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10102">
        <property type="entry name" value="DUF2341"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06739">
        <property type="entry name" value="SBBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02608">
        <property type="entry name" value="delta_60_rpt"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="13"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="482"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1026"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1123"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1221"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1317"/>
            <end position="1414"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1710"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2108"/>
            <end position="2202"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2303"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2399"/>
            <end position="2493"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2823"/>
            <end position="2916"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="2921"/>
            <end position="3016"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="3312"/>
            <end position="3408"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="3409"/>
            <end position="3499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1209"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="3507" mass="371767" checksum="9DCC92DED5B19DBA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SU0</accession>
    <name>Q39SU0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2459</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512441.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32684">
        <property type="protein sequence ID" value="ABB32684"/>
        <property type="gene ID" value="Gmet_2459"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2459"/>
    <dbReference type="HOGENOM" id="CLU_673973_0_0_7"/>
    <dbReference type="OMA" id="YYYVYGD"/>
    <dbReference type="OrthoDB" id="1061199at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="406" mass="45452" checksum="86EAC10944722D47" modified="2005-11-22" version="1">MVKRILHSLFSSRVGIACAAAVVVFAVCTSMVRFRPYWHFEGIYVLKGGNGLLEIKDDLVLGDENRLVLALPAQPLLRFLRGDVSYATDATRLEHEWYRFDGSGHVKGHFADGTIFLTCLSRYLDSDGRETRGVFVGGELPYHLNQAGNETLNDTGVSFYDGNRWFHLWCNVNESISPWSNPSSTIAPSLWRFLDSRVAKQTSEELVITSSHEVELDGLPFRIDRAARFTAGARYFTLAIRITNVGQYPGGYYYVYGDEPWVGNYGSSIGNVGWVKDRLVPYEETINPQEHHWAGYFDYGNEAAGEEHNYSGMANFIEWKGNVTPDLVYFSNKIGSFAPPGSRVPLNHPNNRVLFLQWGPRLLASGQSNTIILSIGMADRDPVSGFPVKPDTTLDPALLEPFLPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="44" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SV0</accession>
    <name>Q39SV0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2449"/>
    <dbReference type="EnsemblBacteria" id="ABB32674">
        <property type="protein sequence ID" value="ABB32674"/>
        <property type="gene ID" value="Gmet_2449"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2449"/>
    <dbReference type="HOGENOM" id="CLU_2395511_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="93" mass="10451" checksum="C159B25E0B3E036A" modified="2005-11-22" version="1">MSAIQVGTPSLGRIILLRTTQKARKPPAINNSSIVISSCTHTTNYIRENIYVFVEDFFVFPGHRPSMRDHLTCLKSGLYIELRCSCCSSKSGW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T41</accession>
    <name>LOLD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipoprotein-releasing system ATP-binding protein LolD</fullName>
            <ecNumber evidence="1">7.6.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lolD</name>
        <name type="ordered locus">Gmet_2358</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The complex is composed of two ATP-binding proteins (LolD) and two transmembrane proteins (LolC and LolE).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. Lipoprotein translocase (TC 3.A.1.125) family.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513262.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T41"/>
    <dbReference type="SMR" id="Q39T41"/>
    <dbReference type="STRING" id="269799.Gmet_2358"/>
    <dbReference type="EnsemblBacteria" id="ABB32583">
        <property type="protein sequence ID" value="ABB32583"/>
        <property type="gene ID" value="Gmet_2358"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2358"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="HDMSLAR"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015854">
        <property type="entry name" value="ABC_transpr_LolD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24220:SF654">
        <property type="entry name" value="PTHR24220:SF654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51244">
        <property type="entry name" value="LOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000272089" description="Lipoprotein-releasing system ATP-binding protein LolD">
        <location>
            <begin position="1"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="1">
        <location>
            <begin position="5"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01708"/>
        </source>
    </evidence>
    <sequence length="225" mass="24184" checksum="D2BE2E1E1AC07749" modified="2005-11-22" version="1">MSSLLEVMDLTKGYGSGETRVDVLKGINLTVAEGETIALVGASGTGKSTLLHIMGTLDRPTSGSVRFGGEDVFRLGDAALASFRNHSIGFVFQFHHLLPEFTALENVMMPLLIAGVKRSDAAAPARELLGEVGLAHRLTHKPGELSGGEQQRVAIARALVLSPKLLLADEPTGNLDMKTSDEVHETLERVHRKRGVTLVIVTHNEKLASYMGRTVRLVDGRVVAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TC1</accession>
    <name>Q39TC1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix DNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366030.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2277"/>
    <dbReference type="EnsemblBacteria" id="ABB32503">
        <property type="protein sequence ID" value="ABB32503"/>
        <property type="gene ID" value="Gmet_2277"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2277"/>
    <dbReference type="HOGENOM" id="CLU_2193189_0_0_7"/>
    <dbReference type="OMA" id="PLEDECQ"/>
    <dbReference type="OrthoDB" id="2221982at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="113" mass="12896" checksum="A1E7044775704397" modified="2005-11-22" version="1">MRNDNLPPSPDLLTVEQFAERMQVSRTTIFGWIKAGALKERVHYIRLGRILRFRWGVDLFFNRPTLANNAEDAPETPPQATVGTLDSQRGEAPVNRPPLTLERHKGPVMNLDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TP3</accession>
    <name>Q39TP3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2152</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513053.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2152"/>
    <dbReference type="EnsemblBacteria" id="ABB32381">
        <property type="protein sequence ID" value="ABB32381"/>
        <property type="gene ID" value="Gmet_2152"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2152"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_7"/>
    <dbReference type="OMA" id="CHNQADI"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="6">
        <location>
            <begin position="3"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="302" mass="31923" checksum="D747D369BB1071EB" modified="2005-11-22" version="1">MKALLVCEYREGKLLETSYELVAFAEKLGAEKAMVLIGSEAEAPKVNGTVYLADAGKYGEYNPDVHKKIVLAAIERENPDYVVFVHSSYGWDLAPRVAANLKAAQISEIVDIVDGKFEVGVCNAKLRRTVTPKSGKAVLTIQAGAFSAAAASGTPQLERIEADGASVLEFVGYEPAEKKDVDLTRAEIIVSAGRGVGKKENVPVIAALAKAMGGELGASRPVVDAGWVEHSHQVGTTGQTVSPKLYMACGISGAIQHLAGMKKSDFIVAINKDKDAPIGEVADVLVVADVLQFVPALTAKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U11</accession>
    <name>Q39U11_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2034</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512917.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2034"/>
    <dbReference type="EnsemblBacteria" id="ABB32263">
        <property type="protein sequence ID" value="ABB32263"/>
        <property type="gene ID" value="Gmet_2034"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2034"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="HAINIDV"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="8"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="146"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="449" mass="50449" checksum="CC8F916E206E83CC" modified="2005-11-22" version="1">MQGKAHGKVLIVDDEPNALKVLAAILREEGYSVFKAGDAAEAEQALSKEDIDTVITDMKMPGKDGIQLMDFMAEHYPDIPIIFLTAYGSVDSAVHAITRGAFYYFIKPPDYVKLKGILARAVEQRSLKRELETLRKRVSGGTPARIVGATPEMLRIFETVEAVKDSMSSVLICGETGTGKELIARSLHYGSVRRDKPFVAVNCAAMPRELIESELFGYEKGAFSGAFSRRIGRFEEAAEGTIFLDEIGELEMPLQAKLLRVLQEKEIERLGSNKKIKVNFRLISSTNRNIPSEITAGNFREDLFYRLNVVQVQVPPLRDRREDIPLLAAELVREYGAREGKVLRFDDEVMQVFLNYDWPGNIRQLGNIIERAVVLAKKDRITTKELPEELKPYVVRVESRQQVRTLRELEEAAILAALEESGGNKSHAAKMLGISRKALYKRLGEMEVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U30</accession>
    <name>Q39U30_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese homology domain superfamily protein, selenocysteine-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32244.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2015"/>
    <dbReference type="KEGG" id="gme:Gmet_2015"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1737938_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0711">Selenium</keyword>
    <keyword evidence="3" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223123" evidence="1">
        <location>
            <begin position="23"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="42"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="3">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32244.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="16744" checksum="A85F2195C1DBA166" modified="2012-10-31" version="2">MNRTFALALLLLSIMMTGGTYAEAGDAKVNYISAFAAHTKYKNDNAILIDVMPVVDYEKFHAVGAINLPNDGPADIERIKQMELPFTKKDEIIVYCSUAGEQASARVALVLIERGFTKTYVVRGGRQAVFEAGVPFLERNKIVFSKRKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U79</accession>
    <name>Q39U79_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="journal article" date="2017" name="Proc. Natl. Acad. Sci. U.S.A." volume="114" first="2892" last="2897">
            <title>Oligomeric lipoprotein PelC guides Pel polysaccharide export across the outer membrane of &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt;.</title>
            <authorList>
                <person name="Marmont L.S."/>
                <person name="Rich J.D."/>
                <person name="Whitney J.C."/>
                <person name="Whitfield G.B."/>
                <person name="Almblad H."/>
                <person name="Robinson H."/>
                <person name="Parsek M.R."/>
                <person name="Harrison J.J."/>
                <person name="Howell P.L."/>
            </authorList>
            <dbReference type="PubMed" id="28242707"/>
            <dbReference type="DOI" id="10.1073/pnas.1613606114"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 18-179</scope>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511878.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="5T0Z">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.25 A"/>
        <property type="chains" value="A/B/C/D=18-179"/>
    </dbReference>
    <dbReference type="PDBsum" id="5T0Z"/>
    <dbReference type="SMR" id="Q39U79"/>
    <dbReference type="STRING" id="269799.Gmet_1966"/>
    <dbReference type="EnsemblBacteria" id="ABB32195">
        <property type="protein sequence ID" value="ABB32195"/>
        <property type="gene ID" value="Gmet_1966"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1966"/>
    <dbReference type="eggNOG" id="COG5616">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105029_0_0_7"/>
    <dbReference type="OMA" id="NYTETPQ"/>
    <dbReference type="OrthoDB" id="1498484at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="5T0Z"/>
        </source>
    </evidence>
    <sequence length="179" mass="19219" checksum="93AA404EA9B40F1E" modified="2005-11-22" version="1">MKKIFVVLLVGLLLSGCVTLRQGGGTVSFTDSWALLPFINNTETPYAAERAEAVTAALLHTHGMQKLERTVTETAKGDDHLGLDRGELKQKAALEAAKQKKVRYAIAGTVNEWRYKVGLDGEPVAGFTLQVIELPEEKVVWSGVAGKSGWSRDAVSAVAQQVLDSLIGDLEKAAATNTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UK1</accession>
    <name>PUR5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine cyclo-ligase</fullName>
            <ecNumber evidence="1">6.3.3.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">AIR synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">AIRS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosyl-aminoimidazole synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purM</name>
        <name type="ordered locus">Gmet_1844</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIR synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512002.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UK1"/>
    <dbReference type="SMR" id="Q39UK1"/>
    <dbReference type="STRING" id="269799.Gmet_1844"/>
    <dbReference type="EnsemblBacteria" id="ABB32073">
        <property type="protein sequence ID" value="ABB32073"/>
        <property type="gene ID" value="Gmet_1844"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1844"/>
    <dbReference type="eggNOG" id="COG0150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047116_0_0_7"/>
    <dbReference type="OMA" id="EPLFMTD"/>
    <dbReference type="OrthoDB" id="923547at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00129"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004641">
        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02196">
        <property type="entry name" value="PurM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00741">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004733">
        <property type="entry name" value="PurM_cligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
        <property type="entry name" value="PTHR10520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00878">
        <property type="entry name" value="purM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000258357" description="Phosphoribosylformylglycinamidine cyclo-ligase">
        <location>
            <begin position="1"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00741"/>
        </source>
    </evidence>
    <sequence length="348" mass="37269" checksum="0CDFC4D11400275B" modified="2005-11-22" version="1">MGAKGITYKDAGVDIDAGNTFVKMIKPFVRATSRPEVISDIGGFGGLFSLNTNKYKNPVLVSGTDGVGTKLKIAMMADRHDTVGIDLVAMCVNDIVVQGAEPLFFLDYFATGSLSPERGAAVVKGISEGCIQAGCALIGGETAEMPGFYQDGEYDLAGFTVGVVDRDKIIDGSSITVGNTLIGLASSGLHSNGYSLARKIIFDTLGFGINDMLPGHDRSVADELLTPTRIYVKSVLNLLRDFRVNGIAHITGGGLLENVPRILPKGCKAIIRRDSWTMPEIFRILQNGGNMEWTEMYRTFNCGIGMVLAVPENDVDEVLIRLSGLQEKAFVIGEVAKCEAGTESVEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UR2</accession>
    <name>Q39UR2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513322.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32012">
        <property type="protein sequence ID" value="ABB32012"/>
        <property type="gene ID" value="Gmet_1781"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1781"/>
    <dbReference type="HOGENOM" id="CLU_1719738_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="152" mass="16686" checksum="4839A649A76977DD" modified="2005-11-22" version="1">MKRTFIWMVFPLMGAILFWGIDALVMAHHGTWSTAAWITAKSIALPVACGSAFWQMVKLFFCQDRLMGAAMAMATGIWVSGPLYYIYFYLAFGTRPMSTAEMLFHVALFPITTLMVSLFNGSIGGLLITSALLVILGTGWLGIPGHCEGNHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UZ6</accession>
    <name>Q39UZ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(3R)-hydroxyacyl-(Acyl carrier protein) dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fabZ-1</name>
        <name evidence="1" type="ordered locus">Gmet_1697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31928.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365861.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1697"/>
    <dbReference type="EnsemblBacteria" id="ABB31928">
        <property type="protein sequence ID" value="ABB31928"/>
        <property type="gene ID" value="Gmet_1697"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1697"/>
    <dbReference type="eggNOG" id="COG0764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078912_3_0_7"/>
    <dbReference type="OMA" id="MTEHSEG"/>
    <dbReference type="OrthoDB" id="1763197at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013114">
        <property type="entry name" value="FabA_FabZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30272">
        <property type="entry name" value="PTHR30272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07977">
        <property type="entry name" value="FabA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31928.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="128" mass="13466" checksum="DD3D34EB679E5D09" modified="2012-10-31" version="2">MFNPNPEAYLPHRRPFLLLDRIVALQPGETATAAISVTGGTRHFPDVLLIEAMAQLGGIAAGHEEGEGGFLAAIDRATFIGSASAGDLLEVTVRVIKSFGRLHLLEGEVSVEGRVLATAGFTLGMGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V32</accession>
    <name>Q39V32_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RES domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MbcT/ParT/Res family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511402.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1661"/>
    <dbReference type="DNASU" id="3740511"/>
    <dbReference type="EnsemblBacteria" id="ABB31892">
        <property type="protein sequence ID" value="ABB31892"/>
        <property type="gene ID" value="Gmet_1661"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1661"/>
    <dbReference type="eggNOG" id="ENOG5032TK3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1137097_0_0_7"/>
    <dbReference type="OMA" id="MAPFTHV"/>
    <dbReference type="OrthoDB" id="1154993at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014914">
        <property type="entry name" value="RES_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08808">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00953">
        <property type="entry name" value="RES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RES" evidence="2">
        <location>
            <begin position="71"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="228" mass="25990" checksum="5FD5E72B1DE1986B" modified="2005-11-22" version="1">MKALFVRTNDFQGDVFRNIVSLRESLDLFDDLTDEAGQSQYATVAEARVKELIPIGLIDRGFHYTTAIDYPFTKEPFLLSRYGNGTFGVWYGSLQLETSIHETVFHMMREESMVEGVTGRLVRERAVYLVRARAVLIDLVGKEKRYPDLVSDDYSFTQQIAERLHKEGHPGLLAPSARCAGTNVVAFTPNILNDPRVNCYLTYTYDYQAKSVEVERQPGDVIYSHQFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V44</accession>
    <name>Q39V44_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Outer membrane channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1649</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Skp family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511414.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1649"/>
    <dbReference type="EnsemblBacteria" id="ABB31880">
        <property type="protein sequence ID" value="ABB31880"/>
        <property type="gene ID" value="Gmet_1649"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1649"/>
    <dbReference type="eggNOG" id="COG2825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107528_0_0_7"/>
    <dbReference type="OMA" id="AICVKKD"/>
    <dbReference type="OrthoDB" id="1989435at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.910.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005632">
        <property type="entry name" value="Chaperone_Skp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024930">
        <property type="entry name" value="Skp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35089">
        <property type="entry name" value="PTHR35089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03938">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00935">
        <property type="entry name" value="OmpH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111384">
        <property type="entry name" value="SSF111384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223164" evidence="5">
        <location>
            <begin position="21"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="95"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="207" mass="22854" checksum="6400FAE2AA6E77C9" modified="2005-11-22" version="1">MKPIASIALLLCLVSFSAMAEESPKVLPQPAAEPPKILQPAPELLKTAEPPKLAEPSQAQQPMKIGYVDLSKIATDSAPGKAASAKMKEKTEKYRSQITARQKKLENMKKDIEAKLPSLTSQQRQAKVKELEKKVGEYQKYVQDAEKAMRKTEGELTESMSKAIQKAADDYGKANGFAVIVPKRDLLYLGDKVDVKDVTEDILKSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V56</accession>
    <name>Q39V56_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Malate oxidoreductase, NADP-dependent, phosphate acetyltransferase-like domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">maeB</name>
        <name evidence="11" type="ordered locus">Gmet_1637</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the malic enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511427.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1637"/>
    <dbReference type="EnsemblBacteria" id="ABB31868">
        <property type="protein sequence ID" value="ABB31868"/>
        <property type="gene ID" value="Gmet_1637"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1637"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012366_0_0_7"/>
    <dbReference type="OMA" id="CESTPQD"/>
    <dbReference type="OrthoDB" id="654531at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05311">
        <property type="entry name" value="NAD_bind_2_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045213">
        <property type="entry name" value="Malic_NAD-bd_bact_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012188">
        <property type="entry name" value="ME_PTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036684">
        <property type="entry name" value="ME_PTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="malic" evidence="10">
        <location>
            <begin position="16"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Malic_M" evidence="9">
        <location>
            <begin position="161"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="74"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036684-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="752" mass="82339" checksum="03A59A7C7D5CFD21" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V68</accession>
    <name>Q39V68_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Riboflavin synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ribE</name>
        <name evidence="4" type="ordered locus">Gmet_1625</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511439.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1625"/>
    <dbReference type="EnsemblBacteria" id="ABB31856">
        <property type="protein sequence ID" value="ABB31856"/>
        <property type="gene ID" value="Gmet_1625"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1625"/>
    <dbReference type="eggNOG" id="COG0307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034388_2_0_7"/>
    <dbReference type="OMA" id="HFVTGHV"/>
    <dbReference type="OrthoDB" id="1276859at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00402">
        <property type="entry name" value="Riboflavin_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001783">
        <property type="entry name" value="Lumazine-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026017">
        <property type="entry name" value="Lumazine-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21098">
        <property type="entry name" value="PTHR21098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00677">
        <property type="entry name" value="Lum_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000498">
        <property type="entry name" value="Riboflavin_syn_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00187">
        <property type="entry name" value="ribE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51177">
        <property type="entry name" value="LUMAZINE_BIND"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="Lumazine-binding" evidence="2">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="Lumazine-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="216" mass="22470" checksum="D14C1BA3645AED06" modified="2005-11-22" version="1">MFTGLIEDVGSVRRLERAGGAARLTTATKIPLDSIALGDSVAVNGACLTVVAKGGGELTFDASPETLERTTLGTLGTGAPVNLERALRLGDRLGGHIVTGHVDFIADVSERREVAGNIVFGFRIPGQFARYLVAKGSVTIDGISLTVNTVTDSGFSVNIIPHTAAMTTLNGMKPGGRVNIETDILGKYVERLLAFGSTGQKEGGLSLELLAKSGFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VA6</accession>
    <name>IF2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Translation initiation factor IF-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">infB</name>
        <name type="ordered locus">Gmet_1586</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365850.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VA6"/>
    <dbReference type="SMR" id="Q39VA6"/>
    <dbReference type="STRING" id="269799.Gmet_1586"/>
    <dbReference type="EnsemblBacteria" id="ABB31818">
        <property type="protein sequence ID" value="ABB31818"/>
        <property type="gene ID" value="Gmet_1586"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1586"/>
    <dbReference type="eggNOG" id="COG0532">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006301_5_1_7"/>
    <dbReference type="OMA" id="NRDNRTG"/>
    <dbReference type="OrthoDB" id="79180at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="PTHR43381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="SSF52156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00487">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000228200" description="Translation initiation factor IF-2">
        <location>
            <begin position="1"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="384"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="1">
        <location>
            <begin position="393"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="1">
        <location>
            <begin position="418"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="1">
        <location>
            <begin position="439"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="1">
        <location>
            <begin position="493"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="1">
        <location>
            <begin position="529"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="393"/>
            <end position="400"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="439"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="493"/>
            <end position="496"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="884" mass="96112" checksum="EEAAB5E70414919D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VH9</accession>
    <name>Q39VH9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511556.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1511"/>
    <dbReference type="EnsemblBacteria" id="ABB31745">
        <property type="protein sequence ID" value="ABB31745"/>
        <property type="gene ID" value="Gmet_1511"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1511"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_986129_0_0_7"/>
    <dbReference type="OMA" id="FYRQSGM"/>
    <dbReference type="OrthoDB" id="1514411at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="282" mass="31014" checksum="CC80224F50A71647" modified="2005-11-22" version="1">MSARVTDWMTTLSRLLVLLVLATNIFGCSLMRSSVAALKSTAEFVPTGTDRRVFAEPGAEDVATVAAKELAEAIATVEREQHGPFAGPVEVYVTRDEESFAAFTGVPKEVRGAVILKIFLSGGLRKEPDRIRRILTHELSHLHLGQRLGMVYGYNATLPSWFQEGLAVVVSGGGGAEKMSEEGAVEAILKGKSIIPEANGSFFFKKFANSYGLTPPMFYRQSGMFVAHLQRLDEARFRSFLLAIKDGHGFGDSFAKSYGMGVDEAWQQFTERFKRRQPSAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VJ6</accession>
    <name>Q39VJ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1494"/>
    <dbReference type="EnsemblBacteria" id="ABB31728">
        <property type="protein sequence ID" value="ABB31728"/>
        <property type="gene ID" value="Gmet_1494"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1494"/>
    <dbReference type="HOGENOM" id="CLU_661840_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="415" mass="45481" checksum="70B48BAE91662A72" modified="2005-11-22" version="1">MFTNVSFIVTGTSSATILILCLFIRAIISYKSKTVNKFDARLLIILIGWLFASASLAFLINQSTKWDLITVTLQTAIFYILPLAVSTLSAKERKLLANITILLAVLFALIHLGILWTKNGKLVAKYYFLPKGMNDAYGVSENIATSSGMFYVPRASALIMITTAFLAGRILLKSYKNVFGLFLLLSSLVICLICSISFAQRSFVLILPLVMLIYAGLSFKRRGGIATVFVMIILVGGGYAVIRNASAKSNFTAVMEKRLAEAAKVGSLDPRNARIAANRDALESIVESPLWGIGSIVSSTRSQDAHSILRVGFMGGLPAILMVLVWISTQFLRFAKLLKKCGEPNLGLCLSAFCAVMCACLMMLLNTVPYLFYSMNLVPFGIFVGLFISEYTDMANSRMRNDSVKEPFDTYVSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VM1</accession>
    <name>Q39VM1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase, AMP-forming</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1469</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511600.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1469"/>
    <dbReference type="EnsemblBacteria" id="ABB31703">
        <property type="protein sequence ID" value="ABB31703"/>
        <property type="gene ID" value="Gmet_1469"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1469"/>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_5_7"/>
    <dbReference type="OMA" id="IGDHRKY"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="3">
        <location>
            <begin position="502"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="605" mass="65186" checksum="CDAFE884FA671103" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VM5</accession>
    <name>Q39VM5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511605.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1465"/>
    <dbReference type="EnsemblBacteria" id="ABB31699">
        <property type="protein sequence ID" value="ABB31699"/>
        <property type="gene ID" value="Gmet_1465"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1465"/>
    <dbReference type="eggNOG" id="COG1387">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021963_0_0_7"/>
    <dbReference type="OMA" id="RTWGGFD"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223324" evidence="1">
        <location>
            <begin position="25"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="596" mass="64120" checksum="84A2E43A8B51A252" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VZ7</accession>
    <name>Q39VZ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA exonuclease, beta-lactamase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513164.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1343"/>
    <dbReference type="EnsemblBacteria" id="ABB31577">
        <property type="protein sequence ID" value="ABB31577"/>
        <property type="gene ID" value="Gmet_1343"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1343"/>
    <dbReference type="eggNOG" id="COG1236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009673_5_0_7"/>
    <dbReference type="OMA" id="YLKAMLG"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="13"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="2">
        <location>
            <begin position="255"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="472" mass="51770" checksum="013151E47FA26E5A" modified="2005-11-22" version="1">MEIIHHGGQYGVTGSCHELVISENASILIDCGLFHGHDADTGKGKKHTPFIDFPLDRVQGLVLTHVHIDHCGRIPHLMGAGFQGPIWCSEASALLLPLVLEDAVKVGITRDEGLIERFIGAMKKRLAPLPYGTWRKLGTWDGMDVSLRLQQAGHILGSAYAELSVARPSVQETTASRHDNETVVVFSGDLGAPFTPLLPDPAPPERADILVLESTYGDRLHEGREQRREKLRQVIIRALENRGALLVPAFSIGRTQELLYEIESLIAEHRNDEAATNLPWDDLEIIVDSPLALRVTEVYDRLRHLWDQEATEVVSQGRHPLSFEQMTVIENHNDHRATVDYLRGTARPCVVIAAGGMCAGGRIVNYLKALMGDPRTDILFVGYQAHGTPGRGILEAAQTRTGTGEHTSIDLDGGSYPLRATVHSISGYSAHADQRDLVNFVRGIPVAPRSIRLVHGEEKARKALEGALGIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W47</accession>
    <name>Q39W47_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Winged-helix transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1291</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512075.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1291"/>
    <dbReference type="EnsemblBacteria" id="ABB31527">
        <property type="protein sequence ID" value="ABB31527"/>
        <property type="gene ID" value="Gmet_1291"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1291"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_3_7"/>
    <dbReference type="OMA" id="SYPRRVW"/>
    <dbReference type="OrthoDB" id="817710at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="7"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="133"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="240" mass="27802" checksum="A0B21FAB407921CA" modified="2005-11-22" version="1">MTEEKPHILLVEDEMHLARGICFNLEMEGYRVSHVESGEEALERLAYDRFALIILDVMLPGMDGFAVCERIRTMDSRVPVLILTARSDEGARVTGLQSGADDYLTKPFSLNEFLLRVGGMLRRSSWYRPEPVEEAYRFGDNEVFLLSYHARTAQGEIDLTELEVKMLSLFFQREGEAISRREILENVWGYTSDTETRTLDNFIVRLRKYFEPNPARPIYFHTVRGLGYRFSRKGSEIVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W59</accession>
    <name>Q39W59_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-deoxy-D-manno-octulosonate 8-phosphate phosphatase KdsC</fullName>
            <ecNumber evidence="5">3.1.3.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KDO 8-P phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">kdsC</name>
        <name evidence="9" type="ordered locus">Gmet_1279</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + H2O = 3-deoxy-alpha-D-manno-oct-2-ulosonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11500"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="EC" id="3.1.3.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KdsC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.45" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512088.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1279"/>
    <dbReference type="EnsemblBacteria" id="ABB31515">
        <property type="protein sequence ID" value="ABB31515"/>
        <property type="gene ID" value="Gmet_1279"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1279"/>
    <dbReference type="eggNOG" id="COG1778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106694_0_1_7"/>
    <dbReference type="OMA" id="VFMGVEN"/>
    <dbReference type="OrthoDB" id="1232828at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019143">
        <property type="term" value="F:3-deoxy-manno-octulosonate-8-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010023">
        <property type="entry name" value="KdsC_fam"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006118">
        <property type="entry name" value="KDO8-P_Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01138">
        <property type="entry name" value="C1.6.2:_Deoxy-d-mannose-octulo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01670">
        <property type="entry name" value="KdsC-phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006118-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="171" mass="18866" checksum="1121DDE14ADC2485" modified="2005-11-22" version="1">MKERLSKIRLLLLDVDGVMTDGRIIFDSNGIESKFFNVKDGHGIKMVQRAGIEVGIISGRGSVVVSNRAAELGISLVYQKSLDKLTPYREILGKTGFTDDQVAFVGDDVIDIPVLRRVGFAAAPADAVEDVFPHVHFTTRNRGGWGAVREVCDLLLRGQGKWDEITARYFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W63</accession>
    <name>KDSB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-deoxy-manno-octulosonate cytidylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">CMP-2-keto-3-deoxyoctulosonic acid synthase</fullName>
            <shortName evidence="1">CKS</shortName>
            <shortName evidence="1">CMP-KDO synthase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kdsB</name>
        <name type="ordered locus">Gmet_1275</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-deoxy-alpha-D-manno-oct-2-ulosonate + CTP = CMP-3-deoxy-beta-D-manno-octulosonate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23448"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:85986"/>
            <dbReference type="ChEBI" id="CHEBI:85987"/>
            <dbReference type="EC" id="2.7.7.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; CMP-3-deoxy-D-manno-octulosonate biosynthesis; CMP-3-deoxy-D-manno-octulosonate from 3-deoxy-D-manno-octulosonate and CTP: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KdsB family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.38" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512092.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W63"/>
    <dbReference type="SMR" id="Q39W63"/>
    <dbReference type="STRING" id="269799.Gmet_1275"/>
    <dbReference type="EnsemblBacteria" id="ABB31511">
        <property type="protein sequence ID" value="ABB31511"/>
        <property type="gene ID" value="Gmet_1275"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1275"/>
    <dbReference type="eggNOG" id="COG1212">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065038_0_1_7"/>
    <dbReference type="OMA" id="MSIKEHE"/>
    <dbReference type="OrthoDB" id="1345588at2"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00358">
        <property type="reaction ID" value="UER00476"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008690">
        <property type="term" value="F:3-deoxy-manno-octulosonate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033468">
        <property type="term" value="P:CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009103">
        <property type="term" value="P:lipopolysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02517">
        <property type="entry name" value="CMP-KDO-Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00057">
        <property type="entry name" value="KdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004528">
        <property type="entry name" value="KdsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00466">
        <property type="entry name" value="kdsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000003359" description="3-deoxy-manno-octulosonate cytidylyltransferase">
        <location>
            <begin position="1"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00057"/>
        </source>
    </evidence>
    <sequence length="254" mass="28303" checksum="C267454627761FBD" modified="2005-11-22" version="1">MKITAIIPARYASTRFPGKALAEIIGKPMVQHVYERTAKAGLVSEVIVATDDERVAEAVRAFGGRVEMTSATHETGTDRLAEVAARIDADIIVNVQGDEPLIEPAMIDEAIAPLVADASIRMGTLKSRIKSLHDFLSPNVVKVVTDREGDALYFSRSPLPNFRDKWNDLKDEAFVTGRLLCYKHVGLYVYRRDFLLAFARMAPTPLELAEKLEQLRVLENGFRIRVVETSFESIGVDTPSDLDKVVEKLSRFQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W94</accession>
    <name>Q39W94_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, periplasmic substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31480.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365789.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1244"/>
    <dbReference type="EnsemblBacteria" id="ABB31480">
        <property type="protein sequence ID" value="ABB31480"/>
        <property type="gene ID" value="Gmet_1244"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1244"/>
    <dbReference type="eggNOG" id="COG2984">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058196_4_2_7"/>
    <dbReference type="OMA" id="YVGADSM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06325">
        <property type="entry name" value="PBP1_ABC_unchar_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007487">
        <property type="entry name" value="ABC_transpt-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35271">
        <property type="entry name" value="PTHR35271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04392">
        <property type="entry name" value="ABC_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223353" evidence="1">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31480.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="298" mass="32653" checksum="62C19A85437A36AE" modified="2012-10-31" version="2">MRLVTFVFAFTLVLLGGTSQAAQKVLVLQSLRVAPYEEAAKGVRSVVAGNFRKLVLSDLDGLDVAKAVRDERPDVIVAIGTEAMNRVKRIKDTPIVYLMVFDQHNSLTTGSNITGIGMHVAPERQLVSAQKVMPRLKRVGTLYNPARSGALFRKSQATARSLGIDLVAREVRSSRDVLNLVEGMKGDIEAFLMLPDATLLTPEAIEYLLLFSLNNRIPIITFSDKYVQMGALMALDVDPYEVGRQAGEMVRKIQSGTSPESIPRSEPHGAVITINSRIARKLGLSLNEEALSRAKVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WB2</accession>
    <name>Q39WB2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Purine nucleoside phosphoramidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hinT</name>
        <name evidence="3" type="ordered locus">Gmet_1225</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512144.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1225"/>
    <dbReference type="EnsemblBacteria" id="ABB31462">
        <property type="protein sequence ID" value="ABB31462"/>
        <property type="gene ID" value="Gmet_1225"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1225"/>
    <dbReference type="eggNOG" id="COG0537">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056776_8_1_7"/>
    <dbReference type="OMA" id="SDCLFCK"/>
    <dbReference type="OrthoDB" id="1934382at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="PTHR23089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="SSF54197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="1">
        <location>
            <begin position="98"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="114" mass="12549" checksum="F8D519DC820A29F7" modified="2005-11-22" version="1">MDNCIFCKIINGTIPARKVYEDDDLVAIEDINPVAPHHILLIPRKHIVNALDLTAGDDALVGRVFRAAAAIARERGVDERGFRIVQNTNADAGQSVFHIHFHLLAGRHLGWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WG0</accession>
    <name>Q39WG0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal recognition particle receptor FtsY</fullName>
            <shortName evidence="5">SRP receptor</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">ftsY</name>
        <name evidence="8" type="ordered locus">Gmet_1176</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. SRP is a ribonucleoprotein composed of Ffh and a 4.5S RNA molecule.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the GTP-binding SRP family. FtsY subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513442.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1176"/>
    <dbReference type="EnsemblBacteria" id="ABB31414">
        <property type="protein sequence ID" value="ABB31414"/>
        <property type="gene ID" value="Gmet_1176"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1176"/>
    <dbReference type="eggNOG" id="COG0552">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009301_3_0_7"/>
    <dbReference type="OMA" id="GISDQFQ"/>
    <dbReference type="OrthoDB" id="656414at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031226">
        <property type="term" value="C:intrinsic component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00920">
        <property type="entry name" value="FtsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004390">
        <property type="entry name" value="SR_rcpt_FtsY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF7">
        <property type="entry name" value="PTHR43134:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="SSF47364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00064">
        <property type="entry name" value="ftsY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0675">Receptor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54" evidence="7">
        <location>
            <begin position="324"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="239"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="303"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="351" mass="38311" checksum="B43D2D752E466700" modified="2005-11-22" version="1">MAEEKKGFIKGLWNKIAGAEGAEENPIPEQRTEVAEHPVQAEEPEERKPGLFERLRQGLSKTRDSLVGRIDRLVLGKKEIDADTLEELEEILITADIGVQTTVELIRILEERLSRNELNDGAALRQTLKDEILKRLSRDVRPLAVDSASPFVIMVIGVNGVGKTTTIGKLAARFSREGKKVVLAAGDTFRAAAAEQLEIWGERTGCDVVRHKEGADPSAVVFDGIKAAVARKADVLIVDTAGRLHTKVNLMEELKKVRRIMDREIPGAPHETLLVLDAATGQNALSQAKLFKEAAEVTGIALTKLDGTAKGGIVAAICNEFRIPVRYIGVGEGVDDLRDFDPAEFVDALFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WH5</accession>
    <name>Q39WH5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">5,10-methylenetetrahydrofolate reductase-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513426.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1161"/>
    <dbReference type="EnsemblBacteria" id="ABB31399">
        <property type="protein sequence ID" value="ABB31399"/>
        <property type="gene ID" value="Gmet_1161"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1161"/>
    <dbReference type="eggNOG" id="COG4656">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107569_0_0_7"/>
    <dbReference type="OMA" id="ACGAGLK"/>
    <dbReference type="OrthoDB" id="1284428at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022026">
        <property type="entry name" value="MTHFR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12225">
        <property type="entry name" value="DUF5981"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5981" evidence="1">
        <location>
            <begin position="110"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="215" mass="23200" checksum="B76B68B05CC4124D" modified="2005-11-22" version="1">MIVSKQKPFTEILAALEPVSRVFLIGCAKCATVCKAGGEEQIWQMQEDLIAAGKDVTGSVVIDEACHMLRVQRDLRAKGEMVKGAEALLVLACGAGVQSVSAGSDRLTVAGLDTLFLGNIRRFGQFEQRCSLCGQCLLNETAGICPVTVCPKGLLNGPCGGMDEGRCEVNGDAECVWYQIYLRLRERGKEAPLTAIKPPRDFARNLRPGSLKLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WK7</accession>
    <name>Q39WK7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phage tail protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513393.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1129"/>
    <dbReference type="EnsemblBacteria" id="ABB31367">
        <property type="protein sequence ID" value="ABB31367"/>
        <property type="gene ID" value="Gmet_1129"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1129"/>
    <dbReference type="eggNOG" id="ENOG502Z7JZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101335_2_0_7"/>
    <dbReference type="OMA" id="ECEGWER"/>
    <dbReference type="OrthoDB" id="1735899at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011747">
        <property type="entry name" value="CHP02241"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010667">
        <property type="entry name" value="Phage_T4_Gp19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38009">
        <property type="entry name" value="PTHR38009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06841">
        <property type="entry name" value="Phage_T4_gp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02241">
        <property type="entry name" value="TIGR02241"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="169" mass="18893" checksum="11C06ACA3BCC06E6" modified="2005-11-22" version="1">MAAPLFPVNTHRHDPYRTFKFQVVIDGKVVAGLKKMGALKKKTTPVKWRASNDPSHERVMPGGTSYDPVTLEQGLTHDPVFETWANLVNNIQGDAGMSLKNYRKDIIINVLNLQGKVAISYKLYRAWVSDYQALPDLDAGNMNTIGIQTITLQHEGWERDTSVAEPAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WL1</accession>
    <name>Q39WL1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl:acetate coenzyme A transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513389.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1125"/>
    <dbReference type="EnsemblBacteria" id="ABB31363">
        <property type="protein sequence ID" value="ABB31363"/>
        <property type="gene ID" value="Gmet_1125"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1125"/>
    <dbReference type="eggNOG" id="COG0427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019748_3_0_7"/>
    <dbReference type="OMA" id="PFFKNGM"/>
    <dbReference type="OrthoDB" id="319106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="332"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="531" mass="58265" checksum="BB3BA0FD816ADD12" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WP2</accession>
    <name>Q39WP2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Polyphosphate-dependent ADP kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1092</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyphosphate kinase 2 (PPK2) family. Class I subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513748.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1092"/>
    <dbReference type="EnsemblBacteria" id="ABB31332">
        <property type="protein sequence ID" value="ABB31332"/>
        <property type="gene ID" value="Gmet_1092"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1092"/>
    <dbReference type="eggNOG" id="COG2326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048699_1_0_7"/>
    <dbReference type="OMA" id="RTHYENV"/>
    <dbReference type="OrthoDB" id="953793at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016898">
        <property type="entry name" value="Polyphosphate_phosphotransfera"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022300">
        <property type="entry name" value="PPK2-rel_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022488">
        <property type="entry name" value="PPK2-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03976">
        <property type="entry name" value="PPK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028756">
        <property type="entry name" value="PPK2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03709">
        <property type="entry name" value="PPK2_rel_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PPK2" evidence="4">
        <location>
            <begin position="50"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="299" mass="34863" checksum="AE6BBA1166D07BAC" modified="2005-11-22" version="1">MSETIKKAKSFAKSFRVEEGKKFRLKDHDPNETLGLKHEEGIKDRSAEFLQQGVEILAEMQEMLYAQDRWGLLLIFQAMDAAGKDGAIKHVMSGVNPQGCQVFNFKAPSAEELDHDFLWRSGKCLPERGRIGIFNRSYYEEVLVVRVHRELLEKQKLPPQLVTKDIWKERYEDINAYERYLTRNGIAIRKFFLNVSRGEQKKRFLERLDNPDKNWKFSVADAQERRHWDKYMDAYEDMIRHTATEYAPWYVVPADNKWFSRLVVAGGIIEALDGLQLAYPEVDEAKRKELAAARAMLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WU1</accession>
    <name>Q39WU1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin biosynthesis sulfur carrier protein sulfurylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">moeB</name>
        <name evidence="2" type="ordered locus">Gmet_1043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513216.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1043"/>
    <dbReference type="EnsemblBacteria" id="ABB31283">
        <property type="protein sequence ID" value="ABB31283"/>
        <property type="gene ID" value="Gmet_1043"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1043"/>
    <dbReference type="eggNOG" id="COG0476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013325_10_4_7"/>
    <dbReference type="OMA" id="WYGHVAT"/>
    <dbReference type="OrthoDB" id="1408716at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="PTHR10953"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="SSF69572"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiF" evidence="1">
        <location>
            <begin position="49"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="280" mass="29923" checksum="8FFDC24CADC84FE2" modified="2005-11-22" version="1">MELYDFITAAAPAGLFPWTAQVEAAERFGLTLGRVEEAALEQGIMPARYQRNRQTITVGNQLRLCRSCAVIIGSGGLGGYLIEELARLGVGNLVVVDPDIFEEHNLNRQILSSPAFLGHPKVEVAAARVGEINPAVTVTPLQLSFSRENGQGILAGSDVVMDGLDSIATRIELAECCRGLSIPLVHGAIGGWYGQVASQLPGDDIVPSLFGNWSEPKGVESQLGNPSFTPAVVASLQVAEACKILLGEGESLRHRMIYVNLLHMEFDEVLLEPPLAAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WU2</accession>
    <name>Q39WU2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphate-selective outer membrane channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513215.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1042"/>
    <dbReference type="EnsemblBacteria" id="ABB31282">
        <property type="protein sequence ID" value="ABB31282"/>
        <property type="gene ID" value="Gmet_1042"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1042"/>
    <dbReference type="eggNOG" id="COG3746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041542_0_0_7"/>
    <dbReference type="OMA" id="LKYYWEY"/>
    <dbReference type="OrthoDB" id="1578713at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010870">
        <property type="entry name" value="Porin_O/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07396">
        <property type="entry name" value="Porin_O_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223227" evidence="1">
        <location>
            <begin position="25"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="414" mass="45764" checksum="CF2053AB00A7C40D" modified="2005-11-22" version="1">MKHRNIAAVSAILAATMACTTAEAKTLEDILKEKGVITEADYKEVTKSKAFDYKVGNGFTLTSPDEKFQLTLGGRLQTRYTFTDLEENSASKPDSSKWEAKRIKFWLKGYAFTKDLTYLYQVDFANSGSSKMLEHAYLNYRLIDEVQLLAGQTKVPFGRQWLNSSGSQQFVDRSMASDMFRPGYDVGAKLHGDIMKGLATYEFGIYGGAGQSTVRSSNDNAIAARATINPFGKMAYSESDLDTSPKPLLSIGANYYRNTLNKTATTTLETNAITLAGSSGWLGKGLSTFATSEKIDVNAWGVDAAFKWLGASAQAEYLIGQADGQTSNKTLRAHGFYAQAGYCIIPKTVEVAFRYSYVDPNRDTANDLITDTQGAVSYYFSKHNLKLQADVTNTHDQRTKTDDKQYRLQAQIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WU4</accession>
    <name>Q39WU4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tungstate ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">tupB</name>
        <name evidence="6" type="ordered locus">Gmet_1040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513213.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1040"/>
    <dbReference type="EnsemblBacteria" id="ABB31280">
        <property type="protein sequence ID" value="ABB31280"/>
        <property type="gene ID" value="Gmet_1040"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1040"/>
    <dbReference type="eggNOG" id="COG4662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_2_7"/>
    <dbReference type="OMA" id="EVGVAMM"/>
    <dbReference type="OrthoDB" id="1110665at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="5">
        <location>
            <begin position="26"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="228" mass="23847" checksum="40E940B8B16389D9" modified="2005-11-22" version="1">MDFFSESLKTALELITSRDPDVVSAVTVSVVVSLWSTLFASLAGVPAGVAVAVTEFTGKRAVVTLLNTLMALPTVVVGLFVYSLISRQGPLGGFGILFTPWAMVVGQTLLAIPIVANLTMSAIKGADPRIVPTALTLGAGPFESIRRLVVEMRFGIMAAVIAGFGRVIAEVGVAMMLGGNIRGYTRTMTTAIAMETGKGEFALGLALGLILMTVALMINMALNALQQR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X62</accession>
    <name>GMHA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoheptose isomerase</fullName>
            <ecNumber evidence="1">5.3.1.28</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sedoheptulose 7-phosphate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gmhA</name>
        <name type="ordered locus">Gmet_0920</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27489"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:60203"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="EC" id="5.3.1.28"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIS family. GmhA subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.28" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513950.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X62"/>
    <dbReference type="SMR" id="Q39X62"/>
    <dbReference type="STRING" id="269799.Gmet_0920"/>
    <dbReference type="EnsemblBacteria" id="ABB31162">
        <property type="protein sequence ID" value="ABB31162"/>
        <property type="gene ID" value="Gmet_0920"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0920"/>
    <dbReference type="eggNOG" id="COG0279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080999_4_0_7"/>
    <dbReference type="OMA" id="FLAHKEA"/>
    <dbReference type="OrthoDB" id="1571626at2"/>
    <dbReference type="UniPathway" id="UPA00041">
        <property type="reaction ID" value="UER00436"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008968">
        <property type="term" value="F:D-sedoheptulose 7-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001061">
        <property type="term" value="P:D-glycero-D-manno-heptose 7-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05006">
        <property type="entry name" value="SIS_GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00067">
        <property type="entry name" value="GmhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035461">
        <property type="entry name" value="GmhA/DiaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004515">
        <property type="entry name" value="Phosphoheptose_Isoase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13580">
        <property type="entry name" value="SIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000009066" description="Phosphoheptose isomerase">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="1">
        <location>
            <begin position="34"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="91"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00067"/>
        </source>
    </evidence>
    <sequence length="189" mass="20151" checksum="0313D59ED8C11C55" modified="2005-11-22" version="1">MNEEIMTQLRSHREVMEAVERELTPRIAAFAGMLVAALKGGKKLLVMGNGGSAADAQHFAAEIVGRFKMERRGLPAVALTTDTSILTAIGNDYGFDAVFRRQVEALADEGDVVVGLSTSGSSRNVYDALALANDRGCITVGLLGRDGGTLKDIVDLDVTVPSGDTPRIQEGHITIIHIVCDLVEKGLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X64</accession>
    <name>Q39X64_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cell shape-determining protein MreB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">mreB</name>
        <name evidence="3" type="ordered locus">Gmet_0918</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Forms polymers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Membrane-associated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the FtsA/MreB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513948.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0918"/>
    <dbReference type="EnsemblBacteria" id="ABB31160">
        <property type="protein sequence ID" value="ABB31160"/>
        <property type="gene ID" value="Gmet_0918"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0918"/>
    <dbReference type="eggNOG" id="COG1077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052037_0_0_7"/>
    <dbReference type="OMA" id="MVICIPS"/>
    <dbReference type="OrthoDB" id="410781at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10225">
        <property type="entry name" value="MreB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02207">
        <property type="entry name" value="MreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004753">
        <property type="entry name" value="MreB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01652">
        <property type="entry name" value="SHAPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00904">
        <property type="entry name" value="mreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0133">Cell shape</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="22"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="169"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="217"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="297"/>
            <end position="300"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="347" mass="37125" checksum="F71FEFFFF1BB87DC" modified="2005-11-22" version="1">MLKIFDALFGLFSNDLAIDLGTANTLVYLKGKGIVVREPSVVAVQKTNSGQQKVLAVGMEAKKMLGRTPGSITAIRPMKDGVIADFDITEEMLRYFIHKVHNRKTLVRPRIVICVPSGITQVEKRAVKESAESAGAREVYLIEEPMAAAIGAGLPITEASGNMIVDIGGGTTEVAVISLAGIVYTKSVRVGGDKMDEAIVQYIKRKYNLLIGDRTAELIKIEIGEAYSIGDVRPMEVKGRDLVSGIPKTVEINSDEIRDALSEPVNAIVDAVKICLERTPPELAADIVDKGIVLAGGGALLRNLDALLREETGLPVVTAEDPLSCVVLGSGKVLDELNLLRRVAVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X72</accession>
    <name>Q39X72_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513940.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0910"/>
    <dbReference type="EnsemblBacteria" id="ABB31152">
        <property type="protein sequence ID" value="ABB31152"/>
        <property type="gene ID" value="Gmet_0910"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0910"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011293_1_0_7"/>
    <dbReference type="OMA" id="TNQHFDW"/>
    <dbReference type="OrthoDB" id="864595at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020014">
        <property type="entry name" value="Decahaem_cyt-c_OmcA/MtrC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03507">
        <property type="entry name" value="decahem_SO1788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="731" mass="76719" checksum="E51558423DDD8BF1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X77</accession>
    <name>Q39X77_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513935.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0905"/>
    <dbReference type="EnsemblBacteria" id="ABB31147">
        <property type="protein sequence ID" value="ABB31147"/>
        <property type="gene ID" value="Gmet_0905"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0905"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023673_0_0_7"/>
    <dbReference type="OMA" id="FVWTVTH"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="262"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="491" mass="53135" checksum="19CCEA5F0D14DB9F" modified="2005-11-22" version="1">MENLTVTGLVRLIGAGATMIYVVTDNERRTEQIATQAAARLKGAGSPYVWTCTEGFSRDGAVVEGIDDPVAAVGFALAQPGPLLFLFKDLPWFWGDNPYLIRALKDFAMRAKAKAIVVLGQQEGIPAALREEFVILQQGLPAMEEIKAFFEQARARDPQLAQACQERPGLLNDLVVAAQGLDLLDVERGMRGARAAGEAGGEGLVRSIFETKRAIIRTGGIMEFVANDVTPDQVGGMENLKQWMARREQAFGLEGISSGANLPKGVLMMGIAGCGKSLFVKAIAATWRLPLIRLDMAAVYDGSYGTPESSLRKAFRTAEAVAPCVLWIDEIEAGISTQGFKAEGGPASRILGSFLTWMQEKRAPVFVAATANAIEMLPAEIIRKGRFDEIFYIGLPETKGREEIFRIHLTRRKIGLSAFDVPLLAGSTKGFSGAEIEQAVQAAAFEALTGKRPMTQQDLMAAISRTVPLSVTMAEQIKKIEAWAFKRAVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XC1</accession>
    <name>Q39XC1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PilB/PulE/GspE family ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0861</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513007.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0861"/>
    <dbReference type="EnsemblBacteria" id="ABB31103">
        <property type="protein sequence ID" value="ABB31103"/>
        <property type="gene ID" value="Gmet_0861"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0861"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_10_6_7"/>
    <dbReference type="OMA" id="WTFAAAM"/>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="642" mass="71890" checksum="A9F062C508840E69" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XC4</accession>
    <name>Q39XC4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Iron/zinc/nickel/cobalt/cadmium efflux protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fieF</name>
        <name evidence="8" type="ordered locus">Gmet_0858</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513003.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0858"/>
    <dbReference type="EnsemblBacteria" id="ABB31100">
        <property type="protein sequence ID" value="ABB31100"/>
        <property type="gene ID" value="Gmet_0858"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0858"/>
    <dbReference type="eggNOG" id="COG0053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013430_3_3_7"/>
    <dbReference type="OMA" id="YGHQRIE"/>
    <dbReference type="OrthoDB" id="381612at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="SSF160240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="SSF161111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="ZT_dimer" evidence="7">
        <location>
            <begin position="214"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="299" mass="32697" checksum="E42117EE074F29F4" modified="2005-11-22" version="1">MLREERFNKADRIIAVGFWANAGLMIMKLLAGYFGKSEAVFADGLESACDFIAILSTMIALKVGRQPFDPKHPYGHGKAESIAAVLVSLVIFSTGIGILVKAVHTIMDRTYQTPDLIAVLAALVTIAVKEWLYRYTVSTGKHLESPALAAVAKDHRKDAVTSIATLVGVFGAYLGAGVMDPLAAGLTAFFIFHIGYETCMGAIHDLMDGLPSGDLIQSISEVAEAVDGVEHVHEIRGRRSGQYIIIDLKLDMDPEMTVKRSHDIATTVKRLIFEQFPNVGDVMIHINPHDEEHEDLIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XD4</accession>
    <name>Q39XD4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptide ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512992.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0848"/>
    <dbReference type="EnsemblBacteria" id="ABB31090">
        <property type="protein sequence ID" value="ABB31090"/>
        <property type="gene ID" value="Gmet_0848"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0848"/>
    <dbReference type="eggNOG" id="COG0444">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_23_7"/>
    <dbReference type="OMA" id="QMTEVII"/>
    <dbReference type="OrthoDB" id="1101128at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013563">
        <property type="entry name" value="Oligopep_ABC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08352">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01727">
        <property type="entry name" value="oligo_HPY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="5"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="320" mass="35327" checksum="599C00FA3F7DBC52" modified="2005-11-22" version="1">MPDLLTVKGLTTRFRLSVGDVHAVNGVDFTVAEGETVAVVGESGCGKSVTALSLLRLILPPGVITAGEIVFEGRDLLRLSDEEMQDIRGNRIAMIFQEPMTSLNPVFPIGRQIAEGLIIHRGVSRREALEEAERLLAQVGIPSPAERLRDYPHQLSGGMRQRVMIAMALACKPRLLIADEPTTALDVTIQAQILELMDRLREEHRMALLLITHDLGVVAERANRTLVMYAGQIVEEGPTGTLLTTPLHPYTEGLLASLPQRSEPGRPLTTIPGHVPSLFGDLPGCGFCSRCPQKQWECDRETPQLREITPGHRVRCWKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XE6</accession>
    <name>Q39XE6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MobA-related glycosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512980.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39XE6"/>
    <dbReference type="STRING" id="269799.Gmet_0836"/>
    <dbReference type="DNASU" id="3738290"/>
    <dbReference type="EnsemblBacteria" id="ABB31078">
        <property type="protein sequence ID" value="ABB31078"/>
        <property type="gene ID" value="Gmet_0836"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0836"/>
    <dbReference type="eggNOG" id="COG2068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061980_4_1_7"/>
    <dbReference type="OMA" id="HAAHITE"/>
    <dbReference type="OrthoDB" id="1432587at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_3" evidence="1">
        <location>
            <begin position="5"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="196" mass="20810" checksum="8A25C1D147775A63" modified="2005-11-22" version="1">MNVAAILLAAGKSQRMGLCKQLLQLADRPAVAHCLDTLTAVGLQEIIVVVSPGGDEVAAAVSRYPVVVAVNESDSCDMADSARTGLARLISDPTGVLVALADHPLVRPDTVRALVNRHGEEPDAILIPVHDGAKGHPTLFPAAILQEIGQVATLRDIIGRHRDKVRLVPVADEGVVMDMDVWEDYLAMAERLNPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XH4</accession>
    <name>Q39XH4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0808</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514395.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0808"/>
    <dbReference type="EnsemblBacteria" id="ABB31050">
        <property type="protein sequence ID" value="ABB31050"/>
        <property type="gene ID" value="Gmet_0808"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0808"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_9_7"/>
    <dbReference type="OMA" id="RYFENKD"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032551">
        <property type="entry name" value="BscR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16295">
        <property type="entry name" value="TetR_C_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="191" mass="22160" checksum="2DE07DF85E9D6053" modified="2005-11-22" version="1">MSKVEKRDEIVRAALEVIAEHGFHGAPMALIADRAGVGAGTIYRYFENKDVLIRELYRDMEGRIYPFITEGYVEVKAFRERFIHLGSALLRYFIENPLDFRYLEQFHNSPYGLEYRRERLLGEREGCDVYRELFETGIAQQVLKNVPLPIFFALTFGPLLAVARDHILGFIVLDDALIVRTIEACWDAVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XR0</accession>
    <name>Q39XR0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SEC-C motif domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0722</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514627.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0722"/>
    <dbReference type="EnsemblBacteria" id="ABB30964">
        <property type="protein sequence ID" value="ABB30964"/>
        <property type="gene ID" value="Gmet_0722"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0722"/>
    <dbReference type="eggNOG" id="COG3012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099590_0_0_7"/>
    <dbReference type="OMA" id="WLYVDGD"/>
    <dbReference type="OrthoDB" id="1472440at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="161" mass="17893" checksum="B2FF5428373061BB" modified="2005-11-22" version="1">MSDSCPCGTGRPFADCCEPFITGKRAPLTAEELMRSRYSAYTKVEIGYIHDTTHPEHRGDFDEKGTREWAESSRWEGLEIVSTLAGGADDTEGKVEFIARYRDKDVRRTHHELAEFKKLDGAWYFTDGVGVKAAPATSVKVGRNDPCTCGSGQKYKKCCGK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XZ0</accession>
    <name>RL18_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplR</name>
        <name type="ordered locus">Gmet_0642</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514252.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XZ0"/>
    <dbReference type="SMR" id="Q39XZ0"/>
    <dbReference type="STRING" id="269799.Gmet_0642"/>
    <dbReference type="EnsemblBacteria" id="ABB30884">
        <property type="protein sequence ID" value="ABB30884"/>
        <property type="gene ID" value="Gmet_0642"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0642"/>
    <dbReference type="eggNOG" id="COG0256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098841_0_1_7"/>
    <dbReference type="OMA" id="NKQIYAQ"/>
    <dbReference type="OrthoDB" id="1963491at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_B">
        <property type="entry name" value="Ribosomal_L18_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005484">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004389">
        <property type="entry name" value="Ribosomal_L18_bac-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12899">
        <property type="entry name" value="PTHR12899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00861">
        <property type="entry name" value="Ribosomal_L18p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00060">
        <property type="entry name" value="L18_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000251316" description="50S ribosomal protein L18">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01337"/>
        </source>
    </evidence>
    <sequence length="121" mass="13361" checksum="CF604267125A4327" modified="2005-11-22" version="1">MSPLAQKKVAHLKRKTRVRKKIRGTTDRPRLNVYKSARHIYAQIIDDVTGVTLVSASTVQDESDALKYTGNVEAAKCVGAMVAKKALEKNITSVVFDRNGFLYHGRVKALADSARENGLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y50</accession>
    <name>Q39Y50_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">omcN</name>
        <name evidence="3" type="ordered locus">Gmet_0581</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30824.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512279.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0581"/>
    <dbReference type="EnsemblBacteria" id="ABB30824">
        <property type="protein sequence ID" value="ABB30824"/>
        <property type="gene ID" value="Gmet_0581"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0581"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3880">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_226591_0_0_7"/>
    <dbReference type="OMA" id="ENTHYSY"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010176">
        <property type="entry name" value="C4xCH_C2xCH_motif_GEOSU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09698">
        <property type="entry name" value="GSu_C4xC__C2xCH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01904">
        <property type="entry name" value="GSu_C4xC__C2xCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2632"/>
            <end position="2655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30824.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="2883" mass="302159" checksum="9B77DF6E04028B15" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y59</accession>
    <name>Q39Y59_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ResB-like family cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512269.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0572"/>
    <dbReference type="EnsemblBacteria" id="ABB30815">
        <property type="protein sequence ID" value="ABB30815"/>
        <property type="gene ID" value="Gmet_0572"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0572"/>
    <dbReference type="eggNOG" id="COG1333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_612182_0_0_7"/>
    <dbReference type="OMA" id="YADEHEG"/>
    <dbReference type="OrthoDB" id="1518243at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="8"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="440" mass="49291" checksum="6EDD0A0C99DF2A28" modified="2005-11-22" version="1">MKRFLLSRTTILALFALILGAIVLSYFVPQHMGVPSRALDKWRESHGPLLAAVDFLGLHHMFTTPWFATLLAFFLASLSLSTYQQYRLAKERTFRVGLPGEGWISLPETAMESAVILRKFGYVRIGNQGEVSRHVKHPWGYWGNFLLHVGIVLVVASSLVILVTQHRGLLNLERGETVYPGTPWAVEENGLFVGKFVLPAAVRLESHDPVFWDNGEIKLIESTVAFLYPDRPVERATLGINQPAWLGGVKIYQSHRFGSDFYAEFADRDGKKVVLILPLQIPPRLDEAGYGDFQFNVMPFQIKAKYYADAARKDMLSGNPLLVLRLYDGAALLGELPLRIGESGVLGNYHVRLLKAVPWNGLILVSMSGMPGIFFGFFIIVCGCSLNYFVVPREVWVREGSQTAVSWRAARFAEFYRDEYDELVAALGAMHEQAEAGPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y65</accession>
    <name>Q39Y65_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0566</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512263.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0566"/>
    <dbReference type="EnsemblBacteria" id="ABB30809">
        <property type="protein sequence ID" value="ABB30809"/>
        <property type="gene ID" value="Gmet_0566"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0566"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_4_0_7"/>
    <dbReference type="OMA" id="QLMPTRE"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027570">
        <property type="entry name" value="GeoRSP_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017200">
        <property type="entry name" value="PqqE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037420">
        <property type="entry name" value="PQQ_syn_pqqE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04303">
        <property type="entry name" value="GeoRSP_rSAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="332" mass="35772" checksum="E1A6204FA3764791" modified="2005-11-22" version="1">MPNEVVLEAPLTINWAINNSCNFACRHCYSRGDTHEELPREVLLACLEKVAQAGVFSVNFGGGEPLLHPGILEIACHARSLGLRISMNSNGWLLDREMAGALRDAGFTKVGISIDSHIPKVHDRFRGVAGSHGRAVAALGDLAEAGIDTSISTVICRINNTAIDDLVAFAREQGARQLNFHNFKCSGLGLSHKDELDLTPEEWQEFYRRALAARDGEKGLDISLDDPIIALLGARDTGSLVKGSVCGKLSLNIKANGDMTPCGFIPIVIGNIVRDDLKQVWRDSAVLEKMRNKKPTGKCAGCGKYEDCLGGCSARALALTGDLNSPDPHCWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YA2</accession>
    <name>Q39YA2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis sensory transducer, class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mcp40H-19</name>
        <name evidence="6" type="ordered locus">Gmet_0529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512225.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0529"/>
    <dbReference type="EnsemblBacteria" id="ABB30772">
        <property type="protein sequence ID" value="ABB30772"/>
        <property type="gene ID" value="Gmet_0529"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0529"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_7"/>
    <dbReference type="OMA" id="KMQAINT"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="213"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="270"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="544" mass="57622" checksum="DB8F250F03293947" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YA3</accession>
    <name>Q39YA3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Winged-helix heavy metal transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">czcR</name>
        <name evidence="5" type="ordered locus">Gmet_0528</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512224.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0528"/>
    <dbReference type="EnsemblBacteria" id="ABB30771">
        <property type="protein sequence ID" value="ABB30771"/>
        <property type="gene ID" value="Gmet_0528"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0528"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_7"/>
    <dbReference type="OMA" id="NYEFFGD"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006291">
        <property type="entry name" value="PcoR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01387">
        <property type="entry name" value="cztR_silR_copR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="2">
        <location>
            <begin position="124"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="223" mass="25057" checksum="B2DA26B04B4FA3DD" modified="2005-11-22" version="1">MRILIIEDEKKAAAYLQKGFTENGFSADTAQNGEDGLHLARTEAYDLVILDIMLPGRDGWSVLEELRRGGSEVPVIYLSARDAVQDRVRGLELGADDYLVKPFAFSELLARARNILRRGPARQPERLRVDDLEMDLVGHKAWRGGTPLDLTTKEFLLLSLLLRRKGEVLSRALIADQVWGINFDSDTNIVDVAIRRLRRKVDDPFERKLISTVRGAGYVLDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YH3</accession>
    <name>Q39YH3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 4,6-dehydratase and UDP-2-acetamido-2,6-dideoxy-alpha-D-xylo-4-hexulose 5-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pseB</name>
        <name evidence="3" type="ordered locus">Gmet_0458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513827.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0458"/>
    <dbReference type="EnsemblBacteria" id="ABB30701">
        <property type="protein sequence ID" value="ABB30701"/>
        <property type="gene ID" value="Gmet_0458"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0458"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_4_1_7"/>
    <dbReference type="OMA" id="HEVMIPK"/>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020025">
        <property type="entry name" value="PseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03589">
        <property type="entry name" value="PseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysacc_synt_2" evidence="2">
        <location>
            <begin position="7"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="342" mass="38609" checksum="2FBEDBEA35261322" modified="2005-11-22" version="1">MLTGKSILVTGGTGSFGKKFIETILTSYPEVKRIVVFSRDELKQFEMAQQFPPDRYRQIRYFIGDVRDKDRLYRAFEGIDIVVHAAALKQVPACEYNPFEAIKTNILGAQNIIETALEQGVTKVVALSTDKAAAPINLYGATKLCSDKLFVAANNFRGKNEIKFSVVRYGNVMGSRGSVIPFFLKRKREGVLPVTDERMTRFNITLEDGVKLVLKALDIMWGGEIFVPKIPSYRILDVAKAVDSGCRIEIVGIRPGEKLHEEMITTTDALNTIEFKDYFVILPSMALWNTEQFTNHFGGRHCADGFAYNSGTNSDWLSVEQLRELIYTHLNPDINRRKDDFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YI2</accession>
    <name>Q39YI2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513817.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0449"/>
    <dbReference type="EnsemblBacteria" id="ABB30692">
        <property type="protein sequence ID" value="ABB30692"/>
        <property type="gene ID" value="Gmet_0449"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0449"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029016_5_0_7"/>
    <dbReference type="OMA" id="TGHMFPA"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040570">
        <property type="entry name" value="LAL_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18603">
        <property type="entry name" value="LAL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="2">
        <location>
            <begin position="114"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="404" mass="43780" checksum="F13B0DF0CC87464A" modified="2005-11-22" version="1">MNSEKRPAILVVSAGIMQIPALERARALGYYVIASDRNPEAPGFQLADEHLVLDVKDVEGHVAWAREHGKRVGLKGAFAGADVAITVAAVCEELGLPGVPVEVARRSNNKALMKERWLRDKIPTPWSAEASTLEEAQKILVHTGFPAIVKAVDGAASRGSMRIDRPDQLPAAFKAACATSRTGTAIIEQFVVGKEQSVETIIWKGKHYHVSLADRHFGFAPYAIETAHVDPSNLDKETQKRICEVVDAAADSLGIDFGPAKADMILTDQGPMILEMPARLSGGFHSQYTTPLSSGKDPIKAVMKLAMGEQLDESLLAAKHDRTSICAGIFPEPGIIRSISGIEEARALPGIEQILITKAVGDRVEPMIDNGKRCCWVIAVGEDEKDAWSRIDATRQVIRFETVP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YP1</accession>
    <name>HIS2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyl-ATP pyrophosphatase</fullName>
            <shortName evidence="1">PRA-PH</shortName>
            <ecNumber evidence="1">3.6.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisE</name>
        <name type="ordered locus">Gmet_0390</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + H2O = 1-(5-phospho-beta-D-ribosyl)-5'-AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22828"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="3.6.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRA-PH family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.31" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512362.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YP1"/>
    <dbReference type="SMR" id="Q39YP1"/>
    <dbReference type="STRING" id="269799.Gmet_0390"/>
    <dbReference type="EnsemblBacteria" id="ABB30633">
        <property type="protein sequence ID" value="ABB30633"/>
        <property type="gene ID" value="Gmet_0390"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0390"/>
    <dbReference type="eggNOG" id="COG0140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123337_1_2_7"/>
    <dbReference type="OMA" id="FTHEKGE"/>
    <dbReference type="OrthoDB" id="2022633at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00007"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004636">
        <property type="term" value="F:phosphoribosyl-ATP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11534">
        <property type="entry name" value="NTP-PPase_HisIE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01020">
        <property type="entry name" value="HisE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008179">
        <property type="entry name" value="HisE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021130">
        <property type="entry name" value="PRib-ATP_PPHydrolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01503">
        <property type="entry name" value="PRA-PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03188">
        <property type="entry name" value="histidine_hisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000230175" description="Phosphoribosyl-ATP pyrophosphatase">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01020"/>
        </source>
    </evidence>
    <sequence length="109" mass="12284" checksum="997E3E1B10D09E75" modified="2005-11-22" version="1">MNERDDILQAVYRVIKERKGASADSSYTASLLQKGIDKILKKLGEEATEVVIAGKGGKREEIVYETADLFFHTLVLLGYYDIDPEEIYAELRRRFGTSGIAEKASRPKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YY8</accession>
    <name>Q39YY8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF2169 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514002.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0291"/>
    <dbReference type="EnsemblBacteria" id="ABB30536">
        <property type="protein sequence ID" value="ABB30536"/>
        <property type="gene ID" value="Gmet_0291"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0291"/>
    <dbReference type="eggNOG" id="COG5351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045796_0_0_7"/>
    <dbReference type="OMA" id="HWQARVG"/>
    <dbReference type="OrthoDB" id="994146at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018683">
        <property type="entry name" value="DUF2169"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09937">
        <property type="entry name" value="DUF2169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2169" evidence="1">
        <location>
            <begin position="21"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="337" mass="36997" checksum="293EBCD2D7062B94" modified="2005-11-22" version="1">MDLLNSTPLIASHNILTDRNGAETLLVVVKGTWRIGRNGALSIAGEQVPIQLEPRYLGDPAASSLIYDTDLILEKPGTDCILLGYAWAPKVGVGSVDVTFGVGPLRKTVRVFGERIWMKCLGMVSMSKPAPFEKIPLVWERAFGGSDTSWPEPKEHEFCLENPVGTGLLARKTKLEIDGLRLPNLEDPAHLIKKPTDRPKPVGFGPIPPHWFPRAGYAGTYDDQWRKYVSPLPPDDLDPRFYLAAAPGLTTARHLAGTEQVLVENASRAGRLQFQLPGGTPSVSVQIRAAVLELEMRLGTVIVEPDEERLVLVWRGHQNVHGKIHDVYGVRVGYGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z04</accession>
    <name>Q39Z04_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VI secretion system DUF2094 and ImpA-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513592.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0275"/>
    <dbReference type="EnsemblBacteria" id="ABB30520">
        <property type="protein sequence ID" value="ABB30520"/>
        <property type="gene ID" value="Gmet_0275"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0275"/>
    <dbReference type="eggNOG" id="COG3515">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3913">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_355546_0_0_7"/>
    <dbReference type="OrthoDB" id="95898at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010657">
        <property type="entry name" value="ImpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017739">
        <property type="entry name" value="T6SS-assoc_VCA0119"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017748">
        <property type="entry name" value="TagF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038225">
        <property type="entry name" value="TagF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06812">
        <property type="entry name" value="ImpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16989">
        <property type="entry name" value="T6SS_VasJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09867">
        <property type="entry name" value="TagF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03362">
        <property type="entry name" value="VI_chp_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03373">
        <property type="entry name" value="VI_minor_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ImpA_N" evidence="1">
        <location>
            <begin position="277"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="790" mass="86670" checksum="6E8A49A3AFFFC36F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z18</accession>
    <name>Q39Z18_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4388 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513578.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0261"/>
    <dbReference type="EnsemblBacteria" id="ABB30506">
        <property type="protein sequence ID" value="ABB30506"/>
        <property type="gene ID" value="Gmet_0261"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0261"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031961_0_0_7"/>
    <dbReference type="OMA" id="PIVDVIQ"/>
    <dbReference type="OrthoDB" id="572605at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025497">
        <property type="entry name" value="DUF4388"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14332">
        <property type="entry name" value="DUF4388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4388" evidence="1">
        <location>
            <begin position="4"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="581" mass="63661" checksum="3DF8AA6687A5D5E9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z20</accession>
    <name>Q39Z20_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 3 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513576.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0259"/>
    <dbReference type="EnsemblBacteria" id="ABB30504">
        <property type="protein sequence ID" value="ABB30504"/>
        <property type="gene ID" value="Gmet_0259"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0259"/>
    <dbReference type="eggNOG" id="COG1047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098197_2_1_7"/>
    <dbReference type="OMA" id="AQIYPEH"/>
    <dbReference type="OrthoDB" id="2044224at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="167" mass="18066" checksum="046731977353CB16" modified="2005-11-22" version="1">MKQAQKGDRVKIDFTGKLEDGTVFDSTREVECCESDDCGCESDHGCDDDDCSCEAGPMEITIGGGEFFEQVEEALIGMAPGEKKTVTIPAEDAFGEYDEEKVFTVPKSDLPADLVPEVGLELVLANDDEEEIGVAVVEVTADSVTFDANHPLAGEDLTYEFELVEIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-05-25" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZC4</accession>
    <name>NUBCD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName>NADH-quinone oxidoreductase subunit B/C/D</fullName>
            <ecNumber>7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>NADH dehydrogenase I subunit B/C/D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName>NDH-1 subunit B/C/D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="primary">nuoBCD</name>
        <name type="synonym">nuoB</name>
        <name type="synonym">nuoC</name>
        <name type="synonym">nuoD</name>
        <name type="ordered locus">Gmet_0153</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction>
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of about 13 different subunits. Subunits NuoBCD, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512740.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZC4"/>
    <dbReference type="SMR" id="Q39ZC4"/>
    <dbReference type="STRING" id="269799.Gmet_0153"/>
    <dbReference type="EnsemblBacteria" id="ABB30400">
        <property type="protein sequence ID" value="ABB30400"/>
        <property type="gene ID" value="Gmet_0153"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0153"/>
    <dbReference type="eggNOG" id="COG0377">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_5_0_7"/>
    <dbReference type="OMA" id="GGRMHYM"/>
    <dbReference type="OrthoDB" id="473681at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="PTHR11993"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000358643" description="NADH-quinone oxidoreductase subunit B/C/D">
        <location>
            <begin position="1"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADH dehydrogenase I subunit B" evidence="1">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADH dehydrogenase I subunit C" evidence="1">
        <location>
            <begin position="229"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADH dehydrogenase I subunit D" evidence="1">
        <location>
            <begin position="411"/>
            <end position="791"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <sequence length="791" mass="90369" checksum="8E9C5038E36A6B71" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZF2</accession>
    <name>Q39ZF2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH-dependent flavin oxidoreductase, Oye family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365627.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0123"/>
    <dbReference type="EnsemblBacteria" id="ABB30372">
        <property type="protein sequence ID" value="ABB30372"/>
        <property type="gene ID" value="Gmet_0123"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0123"/>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_2_3_7"/>
    <dbReference type="OMA" id="GNVMIEY"/>
    <dbReference type="OrthoDB" id="1033671at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="1">
        <location>
            <begin position="4"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="374" mass="40962" checksum="B65575BD7C15DFA9" modified="2005-11-22" version="1">MRKVFDETKIHHLTLRNRLVRSATWEGMCRAGGHPTEKLAAYYGTLARGGVGLIISGYAFVRPDGKQLPGQLGIHEDSFAPEARLLTEAVHREGGKICLQLVHCGGQTTARAAGAQPVAPTAVQIDQYPELPRELPEAEIADLVAAFAAGAVRAREWGFDAVQLHAAHGYLINQFLSPLTNRRTDRYGGSLENRCRFLLEISHAVRAAVGKDFPVMVKLNGSDNLNGGLDLEEAVLVARMLDEEGIDAIEVSGGTPASGGQTPVRQGIETREQEAYNLPLAYRIKQVVSCPVMVVGGFRTFELVEGVIRREEADFVSLSRPLIREPNLPRRWEEGDESRARCISCNGCFKPGMKEGGIYCVVDKVERESRAFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZI3</accession>
    <name>Q39ZI3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional regulator, Crp/Fnr family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fnr-1</name>
        <name evidence="4" type="ordered locus">Gmet_0092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514749.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0092"/>
    <dbReference type="EnsemblBacteria" id="ABB30341">
        <property type="protein sequence ID" value="ABB30341"/>
        <property type="gene ID" value="Gmet_0092"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0092"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_4_0_7"/>
    <dbReference type="OMA" id="IDFWGKE"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012318">
        <property type="entry name" value="HTH_CRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13545">
        <property type="entry name" value="HTH_Crp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00034">
        <property type="entry name" value="HTHCRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00419">
        <property type="entry name" value="HTH_CRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51063">
        <property type="entry name" value="HTH_CRP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="2">
        <location>
            <begin position="12"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="HTH crp-type" evidence="3">
        <location>
            <begin position="146"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="230" mass="25493" checksum="E3FBB16EB5854011" modified="2005-11-22" version="1">MELTEILKKSLLFSGLDGENLSDVAAIATRRPFARGESLFSEGEPASGFYLLAQGSMKLCKVSPDGKEKVLHFVHPGETFAEAAFFGDGKYPAEARATEKGEAIFFPREGFMGILERNPRFSLNLIVSLSLMLRRFARQIEELTFAEVPARLAAHLVELAERKSTAFQGKTYLDLDMKKGELASRLGTVSETLSRAFRKLKEEGLIEVEGSRVVIFDMEKLKDAAGRRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZI5</accession>
    <name>Q39ZI5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">6-O-methylguanine-DNA methyltransferase</fullName>
            <shortName evidence="7">MGMT</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">ogt</name>
        <name evidence="10" type="ordered locus">Gmet_0090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 7">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = a 2'-deoxyguanosine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MGMT family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514747.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0090"/>
    <dbReference type="EnsemblBacteria" id="ABB30339">
        <property type="protein sequence ID" value="ABB30339"/>
        <property type="gene ID" value="Gmet_0090"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0090"/>
    <dbReference type="eggNOG" id="COG0350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_52_2_7"/>
    <dbReference type="OMA" id="INNPKSC"/>
    <dbReference type="OrthoDB" id="1327994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA dealkylation involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00772">
        <property type="entry name" value="OGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008332">
        <property type="entry name" value="MethylG_MeTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023546">
        <property type="entry name" value="MGMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036631">
        <property type="entry name" value="MGMT_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02870">
        <property type="entry name" value="Methyltransf_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="SSF46767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53155">
        <property type="entry name" value="SSF53155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 7 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_1N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="DNA_binding_1" evidence="8">
        <location>
            <begin position="78"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; methyl group acceptor" evidence="7">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="169" mass="18080" checksum="3E9F43457D310080" modified="2005-11-22" version="1">MKRYCTIKTPLGDMVALAEGDELSGLWFTDQKYVPADAGDRMHDQDHPLFAELRRQLDAYFAGMLQTFDLPLAPQGTPFQMAVWELLRTIPPGTTTSYGALAVRMAQGRGGRITSARAVGSAVGRNPIDIIIPCHRVIGADGSLTGYAGGLKRKAALLALERGGGLPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZK1</accession>
    <name>Q39ZK1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bro-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514198.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0074"/>
    <dbReference type="EnsemblBacteria" id="ABB30323">
        <property type="protein sequence ID" value="ABB30323"/>
        <property type="gene ID" value="Gmet_0074"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0074"/>
    <dbReference type="eggNOG" id="COG3943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065349_1_0_7"/>
    <dbReference type="OrthoDB" id="872571at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003497">
        <property type="entry name" value="BRO_N_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02498">
        <property type="entry name" value="Bro-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bro-N" evidence="1">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="123" mass="13920" checksum="C8A53F30F30CA218" modified="2005-11-22" version="1">MSKRLSKDIAGKHVSPFEQIKRTNDAGSEFWSSRDFAQILDYADYRNFEQVVTKARTACFNSGQRIDDHFVDVTEMVDLGSGAKRQVKSVFLSRYACYLIVQNADPSKEIVALGQTYCRLPTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZP5</accession>
    <name>CH60_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperonin GroEL</fullName>
            <ecNumber evidence="1">5.6.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">60 kDa chaperonin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Chaperonin-60</fullName>
            <shortName evidence="1">Cpn60</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">groEL</name>
        <name evidence="1" type="synonym">groL</name>
        <name type="ordered locus">Gmet_0029</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + a folded polypeptide = ADP + phosphate + an unfolded polypeptide.</text>
            <dbReference type="EC" id="5.6.1.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <dbReference type="EC" id="5.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513795.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZP5"/>
    <dbReference type="SMR" id="Q39ZP5"/>
    <dbReference type="STRING" id="269799.Gmet_0029"/>
    <dbReference type="PRIDE" id="Q39ZP5"/>
    <dbReference type="EnsemblBacteria" id="ABB30279">
        <property type="protein sequence ID" value="ABB30279"/>
        <property type="gene ID" value="Gmet_0029"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0029"/>
    <dbReference type="eggNOG" id="COG0459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016503_3_0_7"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="265347at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="SSF48592"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="SSF52029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="SSF54849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000256915" description="Chaperonin GroEL">
        <location>
            <begin position="1"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="29"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="477"/>
            <end position="479"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00600"/>
        </source>
    </evidence>
    <sequence length="546" mass="58015" checksum="82F24D544FD70403" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYG0</accession>
    <name>J7LYG0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3609"/>
    <dbReference type="EnsemblBacteria" id="AFR42828">
        <property type="protein sequence ID" value="AFR42828"/>
        <property type="gene ID" value="Gmet_3609"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3609"/>
    <dbReference type="HOGENOM" id="CLU_2246105_0_0_7"/>
    <dbReference type="OMA" id="VEYPDHY"/>
    <dbReference type="OrthoDB" id="2217212at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003794736" evidence="2">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFR42828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="104" mass="11216" checksum="489114561DD3D17D" modified="2012-10-31" version="1">MKLAVVAGMVLLPHVLFADTDCRVDEYPDHYVVVCTGEEKAEPPAPRPSTIGQSATAATSATPIQAAIQDHSTDSINGPRPGRMSRSRLEAAITARNRFLQENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2022-01-19" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>J7M081</accession>
    <name>J7M081_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514788.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3587"/>
    <dbReference type="EnsemblBacteria" id="AFR42802">
        <property type="protein sequence ID" value="AFR42802"/>
        <property type="gene ID" value="Gmet_3587"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3587"/>
    <dbReference type="eggNOG" id="COG3303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_768951_0_0_7"/>
    <dbReference type="OMA" id="AGQQYAC"/>
    <dbReference type="OrthoDB" id="67559at1224"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3820.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038266">
        <property type="entry name" value="NapC/NirT_cytc_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5003794698" evidence="2">
        <location>
            <begin position="21"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFR42802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="360" mass="37217" checksum="1C51F8B4EF290ED7" modified="2012-10-31" version="1">MKRIVITTAALLAMAAPAMAGHTAAVGQGNCSYCHKVNLVTQHGGFAATVCQTCHDIPATDGMATAVKDTIAAGVAGQQYACSNCHGSQSHAQKHPGYAANYSTYNGVEPGYGTTTWTGATSYTPATPAAKMYQLCVKCHSSNGLGATTNATSGVVGPSGLNLTDQAWEFSPTNRSAHPVIVTLNNQTGSPAPRALKTTEMKAPWLNVGNQTMTCADCHDFVDTGIQGAGITWSLKGTNKAWPYTVAGVTTGTFQTMNNNSMSFCWNCHNFSGAGEVHTTGDHSGVKCIDCHIRVPHGGKVSRLIGTATPGLPARYSGDGKGGEMPHVTAFKKAASGTYGTSSCSTNCGEHGSISGGETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2022-05-25" version="38" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEL8</accession>
    <name>J9JEL8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">prx-4</name>
        <name evidence="5" type="ordered locus">Gmet_0150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0150"/>
    <dbReference type="KEGG" id="gme:Gmet_0150"/>
    <dbReference type="eggNOG" id="COG1225">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_14_1_7"/>
    <dbReference type="OMA" id="MNTHADR"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0711">Selenium</keyword>
    <keyword evidence="5" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="2"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="5">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="AFR42786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="156" mass="17102" checksum="2364EA7811798581" modified="2012-10-31" version="1">MSLEGKQAPDFTLEGSDGRKHSLKDYAGKTTVIYFYPKDSTPGUTKEANGFRDLKPEFDKLGIGILGVSKDSLKAHDKFVRDQEIPFTLLSDPDTTMMTAYGAFGNKLLYGKTTLGVIRSTVVVGPDGTVMKHWPKVAKADAHPAQVLDYLRKTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PW7</accession>
    <name>Q39PW7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3502</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513658.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3502"/>
    <dbReference type="EnsemblBacteria" id="ABB33707">
        <property type="protein sequence ID" value="ABB33707"/>
        <property type="gene ID" value="Gmet_3502"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3502"/>
    <dbReference type="HOGENOM" id="CLU_189842_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004222972" evidence="2">
        <location>
            <begin position="21"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="72" mass="7104" checksum="1A692BE8F38734E2" modified="2005-11-22" version="1">MKAIANALIVTIVTASSALAASGAAADEGGFLAPLFLTLGAAVIAFQTIPAIVLLGSMVKGLFSGKEEEGAR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q78</accession>
    <name>PDRP_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative pyruvate, phosphate dikinase regulatory protein</fullName>
            <shortName evidence="1">PPDK regulatory protein</shortName>
            <ecNumber evidence="1">2.7.11.32</ecNumber>
            <ecNumber evidence="1">2.7.4.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_3384</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ADP + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase] = AMP + H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase]</text>
            <dbReference type="Rhea" id="RHEA:43692"/>
            <dbReference type="Rhea" id="RHEA-COMP:10650"/>
            <dbReference type="Rhea" id="RHEA-COMP:10651"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + N(tele)-phospho-L-histidyl/O-phospho-L-threonyl-[pyruvate, phosphate dikinase] + phosphate = diphosphate + N(tele)-phospho-L-histidyl/L-threonyl-[pyruvate, phosphate dikinase]</text>
            <dbReference type="Rhea" id="RHEA:43696"/>
            <dbReference type="Rhea" id="RHEA-COMP:10650"/>
            <dbReference type="Rhea" id="RHEA-COMP:10651"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:83586"/>
            <dbReference type="EC" id="2.7.4.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.32" evidence="1"/>
    <dbReference type="EC" id="2.7.4.27" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512610.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Q78"/>
    <dbReference type="SMR" id="Q39Q78"/>
    <dbReference type="STRING" id="269799.Gmet_3384"/>
    <dbReference type="PRIDE" id="Q39Q78"/>
    <dbReference type="EnsemblBacteria" id="ABB33596">
        <property type="protein sequence ID" value="ABB33596"/>
        <property type="gene ID" value="Gmet_3384"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3384"/>
    <dbReference type="eggNOG" id="COG1806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046206_2_1_7"/>
    <dbReference type="OMA" id="YAQCEFE"/>
    <dbReference type="OrthoDB" id="980472at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006470">
        <property type="term" value="P:protein dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006468">
        <property type="term" value="P:protein phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00921">
        <property type="entry name" value="PDRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005177">
        <property type="entry name" value="Kinase-pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026565">
        <property type="entry name" value="PPDK_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31756">
        <property type="entry name" value="PTHR31756"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03618">
        <property type="entry name" value="Kinase-PPPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000316677" description="Putative pyruvate, phosphate dikinase regulatory protein">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00921"/>
        </source>
    </evidence>
    <sequence length="269" mass="30526" checksum="BFC29D7D0FDE44A1" modified="2005-11-22" version="1">MNGSMRHIYLFSDATGETVERVLRAALSQFRDVEARIHRMSKIRTREDILSALEDVLKEPGIVIYTLVDAELAQLLRDEAEAHGLDALDLISSLLFKLSDFFGVAPQNEPGLLYELNTEYHKRIEAVDFTVKHDDGQDPRGLSKADFVLVGVSRSSKTPLSMYLAHKGYKVANVPLVKGIDPPAELFKVDQNKIVGLLIDPHRLLEIRSVRLKNLGQMSRGSYADYEKIEDELNYCRQLYRRNPQWLVIDVTKRSVEESAAEIIQKLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q88</accession>
    <name>Q39Q88_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein GspN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gspN</name>
        <name evidence="2" type="ordered locus">Gmet_3374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512600.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3374"/>
    <dbReference type="EnsemblBacteria" id="ABB33586">
        <property type="protein sequence ID" value="ABB33586"/>
        <property type="gene ID" value="Gmet_3374"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3374"/>
    <dbReference type="eggNOG" id="ENOG5033BQ8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_996626_0_0_7"/>
    <dbReference type="OMA" id="EDHASHQ"/>
    <dbReference type="OrthoDB" id="1467970at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030925">
        <property type="entry name" value="T2SS_GspN_Lepto"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04411">
        <property type="entry name" value="T2SS_GspN_Lepto"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="280" mass="29628" checksum="F84BC0D78CEB3D93" modified="2005-11-22" version="1">MTLSRPLRWGAAIVAGILMTVAFTVILIPSRELEGIVSRLLAREGYTFHADRFGKAFPLGISAKGVTIATDEGPVLRFDRVAARLALLPLLTGKAVVTMDATVGPGRVSGSYRPSNGGKGTLEARDVRLEDIPFFKTVAGAEVKGLLTVDASFTGAGPRTAGQLRLEVKGADIRGVAIGGTPLPDAAYDTVRGMVRVASGRATLDSFTLQGADLYIRLKGDSPLATPLGASPLNLTLELMPQPAFLDRQKLVFVLLSKYLVTPGHYQLPVRGALAKPLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QI7</accession>
    <name>Q39QI7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT-like repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3274</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33487.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366171.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3274"/>
    <dbReference type="EnsemblBacteria" id="ABB33487">
        <property type="protein sequence ID" value="ABB33487"/>
        <property type="gene ID" value="Gmet_3274"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3274"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120411_0_0_7"/>
    <dbReference type="OMA" id="SADHEGK"/>
    <dbReference type="OrthoDB" id="1738649at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33487.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="194" mass="20344" checksum="7BBFF64B59256ED9" modified="2012-10-31" version="2">MESNATGKRRERLVPLLKDPAGDVREAAAAALERLEGIGSFAEVAELLKKGDRGTKVKAIYALGKIGGERVLPPLIYCASRPEEDIKSAAIEVLGALGHPRAFPALAQGLQETSTAIRAKAIAALGNYPTPEATRLLIPFLDAGDGFLDAEAALALGRIGGPDLEERLLALLDSPHPQTRQAAATALGMLPLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QL0</accession>
    <name>Q39QL0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">(R)-methylmalonyl-CoA mutase, isobutyryl-CoA mutase-like catalytic subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512689.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3251"/>
    <dbReference type="EnsemblBacteria" id="ABB33464">
        <property type="protein sequence ID" value="ABB33464"/>
        <property type="gene ID" value="Gmet_3251"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3251"/>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_5_1_7"/>
    <dbReference type="OMA" id="IAQKEWV"/>
    <dbReference type="OrthoDB" id="154460at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004494">
        <property type="term" value="F:methylmalonyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006098">
        <property type="entry name" value="MMCoA_mutase_a_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00641">
        <property type="entry name" value="acid_CoA_mut_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="METMALONYL_COA_MUTASE" evidence="1">
        <location>
            <begin position="30"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="552" mass="60703" checksum="790A630FED3DCF90" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QL4</accession>
    <name>Q39QL4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator with cupin-like beta-barrel domain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512685.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3247"/>
    <dbReference type="EnsemblBacteria" id="ABB33460">
        <property type="protein sequence ID" value="ABB33460"/>
        <property type="gene ID" value="Gmet_3247"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3247"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_1_4_7"/>
    <dbReference type="OMA" id="YDSVVPH"/>
    <dbReference type="OrthoDB" id="1292067at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="187" mass="21365" checksum="983768B323E0CCB4" modified="2005-11-22" version="1">MSEYNIGAKIKKLRLAKKLTLQAVARETGFSPALISQIENNNVSPPIATLSKIAKFFDVKISLFFSEDEEEYRYEVVRRGERKVIPRVISRAGTSQGYSYESLSFRKQNKKMEPFLLTVTEKAAEENTYSHDGEEFLFVMKGTAELLLEDERIALEEGDCVYFDSSLRHRLLSRDGNEVQVLAVVTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QM0</accession>
    <name>Q39QM0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rubredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3241</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366166.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3241"/>
    <dbReference type="EnsemblBacteria" id="ABB33454">
        <property type="protein sequence ID" value="ABB33454"/>
        <property type="gene ID" value="Gmet_3241"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3241"/>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128747_5_2_7"/>
    <dbReference type="OrthoDB" id="1608413at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="36" mass="4179" checksum="908B8A4629A9D076" modified="2005-11-22" version="1">MKKWRCVVCDYIHEGPEPPEICPVCGVGRDQFEEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QN8</accession>
    <name>Q39QN8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_3223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512662.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3223"/>
    <dbReference type="EnsemblBacteria" id="ABB33436">
        <property type="protein sequence ID" value="ABB33436"/>
        <property type="gene ID" value="Gmet_3223"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3223"/>
    <dbReference type="eggNOG" id="COG0210">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1379">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005571_0_0_7"/>
    <dbReference type="OMA" id="YLVPAHI"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="9">
        <location>
            <begin position="459"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="10">
        <location>
            <begin position="714"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="8">
        <location>
            <begin position="785"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="423"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="480"/>
            <end position="487"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1075" mass="117608" checksum="FBD3D01858C80F9A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QQ8</accession>
    <name>Q39QQ8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">2,3-bisphosphoglycerate-independent phosphoglycerate mutase</fullName>
            <shortName evidence="8">BPG-independent PGAM</shortName>
            <shortName evidence="8">Phosphoglyceromutase</shortName>
            <shortName evidence="8">iPGM</shortName>
            <ecNumber evidence="8">5.4.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 14" type="primary">gpmI</name>
        <name evidence="14" type="ordered locus">Gmet_3203</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the BPG-independent phosphoglycerate mutase family.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.12" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512641.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3203"/>
    <dbReference type="EnsemblBacteria" id="ABB33416">
        <property type="protein sequence ID" value="ABB33416"/>
        <property type="gene ID" value="Gmet_3203"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3203"/>
    <dbReference type="eggNOG" id="COG0696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026099_2_0_7"/>
    <dbReference type="OMA" id="FMDGRDT"/>
    <dbReference type="OrthoDB" id="338375at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046537">
        <property type="term" value="F:2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006007">
        <property type="term" value="P:glucose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16010">
        <property type="entry name" value="iPGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1450.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01038">
        <property type="entry name" value="GpmI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011258">
        <property type="entry name" value="BPG-indep_PGM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006124">
        <property type="entry name" value="Metalloenzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036646">
        <property type="entry name" value="PGAM_B_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005995">
        <property type="entry name" value="Pgm_bpd_ind"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31637">
        <property type="entry name" value="PTHR31637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06415">
        <property type="entry name" value="iPGM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01676">
        <property type="entry name" value="Metalloenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001492">
        <property type="entry name" value="IPGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64158">
        <property type="entry name" value="SSF64158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01307">
        <property type="entry name" value="pgm_bpd_ind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8 11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metalloenzyme" evidence="12">
        <location>
            <begin position="4"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="iPGM_N" evidence="13">
        <location>
            <begin position="81"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8 10">
        <location>
            <begin position="259"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="8 9">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 11">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001492-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB33416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="512" mass="55298" checksum="8AFB9EABFD7F1345" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QQ9</accession>
    <name>RLMH_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA large subunit methyltransferase H</fullName>
            <ecNumber evidence="1">2.1.1.177</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">23S rRNA (pseudouridine1915-N3)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">23S rRNA m3Psi1915 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">rRNA (pseudouridine-N3-)-methyltransferase RlmH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rlmH</name>
        <name type="ordered locus">Gmet_3202</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>pseudouridine(1915) in 23S rRNA + S-adenosyl-L-methionine = H(+) + N(3)-methylpseudouridine(1915) in 23S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10221"/>
            <dbReference type="Rhea" id="RHEA-COMP:10222"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:74486"/>
            <dbReference type="EC" id="2.1.1.177"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA methyltransferase RlmH family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.177" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512640.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QQ9"/>
    <dbReference type="SMR" id="Q39QQ9"/>
    <dbReference type="STRING" id="269799.Gmet_3202"/>
    <dbReference type="EnsemblBacteria" id="ABB33415">
        <property type="protein sequence ID" value="ABB33415"/>
        <property type="gene ID" value="Gmet_3202"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3202"/>
    <dbReference type="eggNOG" id="COG1576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100552_1_0_7"/>
    <dbReference type="OMA" id="NEPYHHQ"/>
    <dbReference type="OrthoDB" id="1783583at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070038">
        <property type="term" value="F:rRNA (pseudouridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18081">
        <property type="entry name" value="RlmH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00658">
        <property type="entry name" value="23SrRNA_methyltr_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003742">
        <property type="entry name" value="RlmH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33603">
        <property type="entry name" value="PTHR33603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02590">
        <property type="entry name" value="SPOUT_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004505">
        <property type="entry name" value="MT_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000260558" description="Ribosomal RNA large subunit methyltransferase H">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="121"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00658"/>
        </source>
    </evidence>
    <sequence length="154" mass="17689" checksum="CAF5BD8F57A8976F" modified="2005-11-22" version="1">MKLKILWVGKTQEEWLRRGIDEYTGRIRRYTPLEIAEAREEKGAAAEAMRTRECERLEKLVPKNARLVLLDERGDQLTSPELAAFMGKCRDSAVPEMVFAIGGAYGFADSFRARADRVLALSRLTFTHQMVRVILLEQIYRAHTILNGEPYHHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QU4</accession>
    <name>Q39QU4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-dependent DNA helicase DinG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">dinG</name>
        <name evidence="5" type="ordered locus">Gmet_3167</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33380.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513883.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3167"/>
    <dbReference type="EnsemblBacteria" id="ABB33380">
        <property type="protein sequence ID" value="ABB33380"/>
        <property type="gene ID" value="Gmet_3167"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3167"/>
    <dbReference type="eggNOG" id="COG1199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012117_2_0_7"/>
    <dbReference type="OMA" id="VVTNHAM"/>
    <dbReference type="OrthoDB" id="679382at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025657">
        <property type="entry name" value="RadC_JAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020891">
        <property type="entry name" value="UPF0758_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="PTHR11472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04002">
        <property type="entry name" value="RadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01302">
        <property type="entry name" value="UPF0758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="132"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33380.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="839" mass="92637" checksum="C07E22262CFE9826" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QY2</accession>
    <name>Q39QY2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux pump, RND family, membrane fusion lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3128</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514303.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3128"/>
    <dbReference type="EnsemblBacteria" id="ABB33342">
        <property type="protein sequence ID" value="ABB33342"/>
        <property type="gene ID" value="Gmet_3128"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3128"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_4_7"/>
    <dbReference type="OMA" id="GIQDGAY"/>
    <dbReference type="OrthoDB" id="1200399at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="53"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="370" mass="38559" checksum="95B937FB33EC4E75" modified="2005-11-22" version="1">MRMRTITVLLLFAAAVLTFYGCGGGKEGAEKREKPPVVTGIAVEKVAAVTVPEGIEAVGTVKARNAAVIAARIPGTVTGVFAVEGDRVGRGKVLVTLEATESTAQAAAASASAEEARRGLEEARARKRLADATFERYHNLFREEAVTRQELDNRRADKDVADQGVARAEARVAAAREGARAAGAVAGYTRITAPLTGVVTAKQVERGMTVFPGTPLLTVEEEGNYRLEVAVPESLVAKAKVGATVRVAVDGAGAAASGRIAEVVPAADPASRTFTAKVDIAGKGLKSGMFGRVLLSTGEKKGILVPRGAVLERGALTSVWVVDGRNIARMRLVKPGAVQGDRVEILTGLTEGERVVTSGMEKVVEGAEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R01</accession>
    <name>Q39R01_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Flagellum-specific ATPase FliI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">fliI</name>
        <name evidence="5" type="ordered locus">Gmet_3109</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3109"/>
    <dbReference type="EnsemblBacteria" id="ABB33323">
        <property type="protein sequence ID" value="ABB33323"/>
        <property type="gene ID" value="Gmet_3109"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3109"/>
    <dbReference type="eggNOG" id="COG1157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_5_1_7"/>
    <dbReference type="OMA" id="MDSATRF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030257">
        <property type="term" value="C:type III protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030254">
        <property type="term" value="P:protein secretion by the type III secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005714">
        <property type="entry name" value="ATPase_T3SS_FliI/YscN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022425">
        <property type="entry name" value="FliI_clade2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040627">
        <property type="entry name" value="T3SS_ATPase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18269">
        <property type="entry name" value="T3SS_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03497">
        <property type="entry name" value="FliI_clade2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01026">
        <property type="entry name" value="fliI_yscN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="160"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="443" mass="47954" checksum="1AEA83CD6F7F5285" modified="2005-11-22" version="1">MSMDRIDLSRYLTAVETMTPIRFHGKVTQVVGLVIEGYCPDAAVGTLCHVHPHDGDPIPAEVVGFRDNKTLLMPLGELRGVGLGSLISVKRKKSSLGVGPGLLGRVIDGLGEPIDDKGPLATREEYPIYANPVNPMKRRPIREPLDLGIRAINGLLTCGKGQRVGIMAGSGVGKSTLLGMIARYTEADVNVIALIGERGRELREFIEKDLQEEGLKKSVVVVATSDQPPLVRMRGAYIATTIAEYFQAQGKKVLLMMDSATRFAMAMREVGLAIGEPPTTKGYTPSVFAALPKLLERTGNFMDGSITGLYTVLVEGDDFNEPVSDAMRSILDGHIVLNRELAARAIYPPIDVLASASRVMMDVTERGQQQFASRFKELLAAHKQAEDLINIGAYKPGSNPTIDYAISKMEGMVGYIRQGIHDGVTMEQSVTALGDIFDEGMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R17</accession>
    <name>Q39R17_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514547.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3093"/>
    <dbReference type="EnsemblBacteria" id="ABB33307">
        <property type="protein sequence ID" value="ABB33307"/>
        <property type="gene ID" value="Gmet_3093"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3093"/>
    <dbReference type="eggNOG" id="ENOG503343T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174612_5_0_7"/>
    <dbReference type="OrthoDB" id="1954291at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022453">
        <property type="entry name" value="Znf_MqsA-type"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03831">
        <property type="entry name" value="YgiT_finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="73" mass="7938" checksum="0C24572BEAA4267D" modified="2005-11-22" version="1">MKCHNCGGSFEQITTDLPFKTGPHSIIIIKELPVLQCGNCSEFLLEDAVMEKVDAIIAGTGKTVEVEILRYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R32</accession>
    <name>Q39R32_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cardiolipin synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cls-1</name>
        <name evidence="2" type="ordered locus">Gmet_3078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513637.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3078"/>
    <dbReference type="EnsemblBacteria" id="ABB33292">
        <property type="protein sequence ID" value="ABB33292"/>
        <property type="gene ID" value="Gmet_3078"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3078"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038053_0_2_7"/>
    <dbReference type="OMA" id="YVHVEFY"/>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="309"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="396" mass="44809" checksum="A93F045DA7E29ABB" modified="2005-11-22" version="1">MSIVRRKKIIGTHRAPRFLRIFRRNAEASHSRGNRVKLYDSGAEFFPAMLSALAEARHHIHAEFYIVRDDATGSAFAEALLAAASRRVDVSLIYDYIGCFDTPSSYFRRLEQGGVRCLAFNPPPFRRGLAWFDKRDHRKMAVIDGETAFTGGINIGDEYSGFGRGTDRWRDVGVRIDGPAVTDLVRLFREFWLEEKGSPSPAWFAEHIPVAGMGDADVMIVSDGPHHARSFIRNAFRIAMAGAGESIRIMNPYFVPGPRVVRSLLRAVRRGVNVQLILPAKSDVPIVRLVGRGYYAPLLRAGVEIYERQGEFLHAKVMLIDDTWGVVGSANLDQRSFHRNYEVNTIVASREFGRQMAEMFADDLRGSRRIVLEEHERRGSLVRLLERICNSVSWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R46</accession>
    <name>Q39R46_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513623.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3063"/>
    <dbReference type="EnsemblBacteria" id="ABB33278">
        <property type="protein sequence ID" value="ABB33278"/>
        <property type="gene ID" value="Gmet_3063"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3063"/>
    <dbReference type="eggNOG" id="ENOG502Z86K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084423_2_0_7"/>
    <dbReference type="OMA" id="LIVTEAY"/>
    <dbReference type="OrthoDB" id="1411282at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025449">
        <property type="entry name" value="DUF4194"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13835">
        <property type="entry name" value="DUF4194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="206" mass="23631" checksum="D4F40320C24EA3B6" modified="2005-11-22" version="1">MLHELRRMLDKDENLAAEDLRRAASIALDRQFLFGDKSRDQRSFHQILDAEDYYRNLFDALNLELICDRTAGYVGVVPRESHLTVGLDTEHSLFLLVLRVIYERAAQECRVGEFSQVFTDSEVMLDTFVAHTGRKRPGLVRLREILRTFSRQGLLEIDEDEDKAIRFRIRPSIRDIVTHGFLQALEEYTKGGEGEENGTDEAGGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R88</accession>
    <name>Q39R88_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endolytic murein transglycosylase</fullName>
            <ecNumber evidence="7">4.2.2.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Peptidoglycan polymerization terminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yceG</name>
        <name evidence="7" type="synonym">mltG</name>
        <name evidence="8" type="ordered locus">Gmet_3021</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the transglycosylase MltG family.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33236.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3021"/>
    <dbReference type="EnsemblBacteria" id="ABB33236">
        <property type="protein sequence ID" value="ABB33236"/>
        <property type="gene ID" value="Gmet_3021"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3021"/>
    <dbReference type="eggNOG" id="COG1559">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025574_2_0_7"/>
    <dbReference type="OMA" id="IAMPGKA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008932">
        <property type="term" value="F:lytic endotransglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08010">
        <property type="entry name" value="MltG_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02065">
        <property type="entry name" value="MltG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003770">
        <property type="entry name" value="MLTG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30518">
        <property type="entry name" value="PTHR30518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02618">
        <property type="entry name" value="YceG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00247">
        <property type="entry name" value="TIGR00247"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33236.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="335" mass="36583" checksum="4F628FFE5806E44E" modified="2012-10-31" version="2">MKDRRILAASALALLLLLVLPARYLFFLALPAGDGKTVRIVDFAKGESVARIAADLERDGIVSSARIFVIHTRLKGVSGKLQAGEYQFSNGMRPGEILRMMLNGEVAVRRFAVPEGYSIHQLAELLESQKLFSKEGFLKAATDPALLTELGIEGKSVEGYLFPSTYDVTRTMDEAALIRAMTAQFHKVCDGQLADAARRIGMTPFQVVTLASLIEKEAVVATDRPLISSVFHNRLAKGMRLQSDPTAVYGVRAFASAVTKQDIERQTPYNTYLIAGLPPGPIGNPSKGAIEAALNPVRTRYLYFVSKKDGTHHFSTSLDEHNAAVATYLKTNRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RB4</accession>
    <name>Q39RB4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin and NADH nitroreductase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2995</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514486.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2995"/>
    <dbReference type="EnsemblBacteria" id="ABB33210">
        <property type="protein sequence ID" value="ABB33210"/>
        <property type="gene ID" value="Gmet_2995"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2995"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_2_0_7"/>
    <dbReference type="OMA" id="NMELMTN"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="33"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="271" mass="30053" checksum="002C861B336C0898" modified="2005-11-22" version="1">MPDLIVTGSLCTRCGACVATCPARIIELPKGVPRFTATGEARCIICGHCEAVCPTAALTVNDPRLDPTVPPPPEAPLPPEILDAYLRMRRSIRRFRTEAVPRKTIESLLDVVRYAPTSSNRQAVRWLVIHDTAEVRRLTGLVIDWFRSRLADPSCPNRTTLAAMIRSWNNGSDPICRNAPHLVIPCTPRQHSLAPFDATIAAAHLEIVAPAHGIGTCWGGYFQMAAEVWEPLRLALNLSDGYYPECALLLGYPATTYRRPPKRNRLDVTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RC9</accession>
    <name>Q39RC9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan L,D-transpeptidase, YkuD family, LysM domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514471.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2980"/>
    <dbReference type="EnsemblBacteria" id="ABB33195">
        <property type="protein sequence ID" value="ABB33195"/>
        <property type="gene ID" value="Gmet_2980"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2980"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046834_1_0_7"/>
    <dbReference type="OMA" id="LAEYRMY"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="4">
        <location>
            <begin position="104"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="300" mass="32345" checksum="BB79FAAEECF6A0B8" modified="2005-11-22" version="1">MAAPWGNGGNRWRREVALLVWAALLGARLAGATIFPGPAEVVGRSSLQEARKGESLIEVARSHDLGFNEIAAANPGLDPFVPTAGSPVTIPGRHVVPAAVVPGRLVVNLSELRLYFVPEGGTPRIVSFPVGTGSEGKETPLGVYRVTEKRANPAWHVPLSIRQERPRLPAVVPPGPDNPLGSHALRLTDDGLMIHGTNRPWGVGRNVSHGCIRLYPEDIPVLFRLVSLGTPVAIVREPVKVGDQEGRLLIEVHRDEGAGIDYAAEATRLIMARGRLDRVDFPRLFRALAEKRGVPVDIGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RN5</accession>
    <name>RS16_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsP</name>
        <name type="ordered locus">Gmet_2871</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514602.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RN5"/>
    <dbReference type="SMR" id="Q39RN5"/>
    <dbReference type="STRING" id="269799.Gmet_2871"/>
    <dbReference type="EnsemblBacteria" id="ABB33089">
        <property type="protein sequence ID" value="ABB33089"/>
        <property type="gene ID" value="Gmet_2871"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2871"/>
    <dbReference type="eggNOG" id="COG0228">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100590_5_0_7"/>
    <dbReference type="OMA" id="GFYNPIA"/>
    <dbReference type="OrthoDB" id="1937072at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_S16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_S16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_S16_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="PTHR12919"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="SSF54565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000243811" description="30S ribosomal protein S16">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00385"/>
        </source>
    </evidence>
    <sequence length="88" mass="9882" checksum="35948AA5821FD492" modified="2005-11-22" version="1">MAIKMRLARAGAKKKPFYQIVIADVRSRRDGRFIENVGTYDPNQNPAAVKFEEGKALEWLGKGAQPTDTVKQMLKTAGLWEKFTTKPA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RN7</accession>
    <name>RIMM_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation factor RimM</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rimM</name>
        <name type="ordered locus">Gmet_2869</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Binds ribosomal protein S19.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The PRC barrel domain binds ribosomal protein S19.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RimM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514600.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RN7"/>
    <dbReference type="SMR" id="Q39RN7"/>
    <dbReference type="STRING" id="269799.Gmet_2869"/>
    <dbReference type="DNASU" id="3738926"/>
    <dbReference type="EnsemblBacteria" id="ABB33087">
        <property type="protein sequence ID" value="ABB33087"/>
        <property type="gene ID" value="Gmet_2869"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2869"/>
    <dbReference type="eggNOG" id="COG0806">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077636_1_0_7"/>
    <dbReference type="OMA" id="DEFYHAD"/>
    <dbReference type="OrthoDB" id="1497415at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00014">
        <property type="entry name" value="Ribosome_mat_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011961">
        <property type="entry name" value="16S_RimM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027275">
        <property type="entry name" value="PRC-brl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002676">
        <property type="entry name" value="RimM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036976">
        <property type="entry name" value="RimM_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05239">
        <property type="entry name" value="PRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01782">
        <property type="entry name" value="RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="SSF50346"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02273">
        <property type="entry name" value="16S_RimM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="chain" id="PRO_0000244133" description="Ribosome maturation factor RimM">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="PRC barrel" evidence="1">
        <location>
            <begin position="98"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00014"/>
        </source>
    </evidence>
    <sequence length="173" mass="19007" checksum="A05D38835427914D" modified="2005-11-22" version="1">MLGSTDLVLLGKVVATHGIRGQLSVVPFSGEFSTILSMQTVYLSGPDNRKESFEVDRAAVHRNRVLLTLKGFANINEVLHLVGRELFARRDQFPPLDEGEFYWCDLIGLSVTTSEGLSLGRIEEIIATGSNDVYVVRDGEREYLIPALEDIVVGVDLDKGIMTVSPTEGLLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RR7</accession>
    <name>Q39RR7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">omcX</name>
        <name evidence="3" type="ordered locus">Gmet_2839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513964.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2839"/>
    <dbReference type="EnsemblBacteria" id="ABB33057">
        <property type="protein sequence ID" value="ABB33057"/>
        <property type="gene ID" value="Gmet_2839"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2839"/>
    <dbReference type="eggNOG" id="ENOG5032RAW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962277_0_0_7"/>
    <dbReference type="OMA" id="LACVYCH"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223202" evidence="2">
        <location>
            <begin position="32"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="289" mass="31210" checksum="085D876C6241FCF8" modified="2005-11-22" version="1">MNAVRRIRLFAVAGLTLAVSLCLGAGSPVKAAPAAPKLVQDDCVKCHAKPPADIASAGAGHKKITCFDCHAGHRPASQNNIPKCSQCHTGKKHYELPNCLGCHKNPHTPLNIILSGNLTEPCLSCHTQQIEQLKQFPSKHSKLFCSTCHNVHGKIPACTQCHKPHYAEQTAGDCKKCHKAHQPKNVAYGKEIPNKDCGACHKKALDLLTASQAKHKSLACVYCHQDKHKMVPACQSCHGVPHPAAMMSKFSKCGECHNIAHDLNHWSSPAKAEPAKAAPAKPTMKKKKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RS2</accession>
    <name>HCP_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hydroxylamine reductase</fullName>
            <ecNumber evidence="1">1.7.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Hybrid-cluster protein</fullName>
            <shortName evidence="1">HCP</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Prismane protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hcp</name>
        <name type="ordered locus">Gmet_2834</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>A + H2O + NH4(+) = AH2 + H(+) + hydroxylamine</text>
            <dbReference type="Rhea" id="RHEA:22052"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15429"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="1.7.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </cofactor>
        <text evidence="1">Binds 1 hybrid [4Fe-2O-2S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HCP family.</text>
    </comment>
    <dbReference type="EC" id="1.7.99.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513969.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RS2"/>
    <dbReference type="SMR" id="Q39RS2"/>
    <dbReference type="STRING" id="269799.Gmet_2834"/>
    <dbReference type="EnsemblBacteria" id="ABB33052">
        <property type="protein sequence ID" value="ABB33052"/>
        <property type="gene ID" value="Gmet_2834"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2834"/>
    <dbReference type="eggNOG" id="COG1151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038344_2_0_7"/>
    <dbReference type="OMA" id="EINLKCM"/>
    <dbReference type="OrthoDB" id="337713at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050418">
        <property type="term" value="F:hydroxylamine reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01914">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2030">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00069">
        <property type="entry name" value="Hydroxylam_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004137">
        <property type="entry name" value="HCP/CODH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010048">
        <property type="entry name" value="Hydroxylam_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016099">
        <property type="entry name" value="Prismane-like_a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011254">
        <property type="entry name" value="Prismane-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016100">
        <property type="entry name" value="Prismane_a-bundle"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109">
        <property type="entry name" value="PTHR30109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30109:SF0">
        <property type="entry name" value="PTHR30109:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03063">
        <property type="entry name" value="Prismane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000076">
        <property type="entry name" value="HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56821">
        <property type="entry name" value="SSF56821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01703">
        <property type="entry name" value="hybrid_clust"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000092338" description="Hydroxylamine reductase">
        <location>
            <begin position="1"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="318"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via persulfide group" evidence="1">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>hybrid [4Fe-2O-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:60519"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Cysteine persulfide" evidence="1">
        <location>
            <position position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00069"/>
        </source>
    </evidence>
    <sequence length="549" mass="59644" checksum="6BCE1250DE69441F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RX0</accession>
    <name>Q39RX0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carbamate kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cpkA</name>
        <name evidence="4" type="ordered locus">Gmet_2786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the carbamate kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511676.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2786"/>
    <dbReference type="EnsemblBacteria" id="ABB33004">
        <property type="protein sequence ID" value="ABB33004"/>
        <property type="gene ID" value="Gmet_2786"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2786"/>
    <dbReference type="eggNOG" id="COG0549">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076278_0_0_7"/>
    <dbReference type="OMA" id="ETTPYPM"/>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008804">
        <property type="term" value="F:carbamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006525">
        <property type="term" value="P:arginine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04235">
        <property type="entry name" value="AAK_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003964">
        <property type="entry name" value="Carb_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30409">
        <property type="entry name" value="PTHR30409"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000723">
        <property type="entry name" value="Carbamate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AA_kinase" evidence="3">
        <location>
            <begin position="9"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR000723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="314" mass="33400" checksum="640AEE33B4A4AD49" modified="2005-11-22" version="1">MTHTVNRPILLIALGGNALIRQGEQGTCAEQFANLRRPMEQIARLADRYRIIITHGNGPQVGNLLMQQESCPEVPAMPLEVLVAQTQGQIGYMIESSLESELLALGGEKRFLVSLISYVQVAEDDPAFRTPTKPIGPCYTAEEAARFPWPMAGTPKGYRRVVASPEPLAVVEKEEIRRLVEVDFIVVCCGGGGIPVTREGRAFHGIDAVIDKDLASACLCLEVGVDILVIATDVPGVATGFGTAAEEFLKRLDADEAGRLLAAGQFPPGSMGPKVEAVLRFVRGGGKRGVICHLDEIEQAVAGTAGTEITGGGS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S09</accession>
    <name>LIPB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Octanoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.181</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Lipoate-protein ligase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipoyl/octanoyl transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Octanoyl-[acyl-carrier-protein]-protein N-octanoyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lipB</name>
        <name type="ordered locus">Gmet_2747</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-lysyl-[protein] + octanoyl-[ACP] = H(+) + holo-[ACP] + N(6)-octanoyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:17665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9636"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78463"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="EC" id="2.3.1.181"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LipB family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.181" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511712.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39S09"/>
    <dbReference type="SMR" id="Q39S09"/>
    <dbReference type="STRING" id="269799.Gmet_2747"/>
    <dbReference type="EnsemblBacteria" id="ABB32965">
        <property type="protein sequence ID" value="ABB32965"/>
        <property type="gene ID" value="Gmet_2747"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2747"/>
    <dbReference type="eggNOG" id="COG0321">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035168_1_3_7"/>
    <dbReference type="OMA" id="GEVTYHC"/>
    <dbReference type="OrthoDB" id="1806796at2"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00592"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033819">
        <property type="term" value="F:lipoyl(octanoyl) transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16444">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00013">
        <property type="entry name" value="LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000544">
        <property type="entry name" value="Octanoyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020605">
        <property type="entry name" value="Octanoyltransferase_CS"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016262">
        <property type="entry name" value="LPLase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00214">
        <property type="entry name" value="lipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01313">
        <property type="entry name" value="LIPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000242725" description="Octanoyltransferase">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="BPL/LPL catalytic" evidence="2">
        <location>
            <begin position="28"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="1">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="146"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Cys" evidence="1">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01067"/>
        </source>
    </evidence>
    <sequence length="213" mass="22962" checksum="FBEB1D7B241AA40B" modified="2005-11-22" version="1">MMIRDLGKLEFEAALAIQEQLAAGVAAGTSPETLLLLEHPPVYTIGRGGCRENVLDPGIRVVEANRGGDVTFHGPGQLVGYPVIDLGRRGRDLHRYLRILEELLINVAAEFGVAARREPGRTGIWTDGGKLASIGVGVRRWVTMHGFALNVTNELAPFRSINPCGIVACPITSLSAILGRPVPLGDVRRSVAGRFPFLLDERLPFLETAEPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S11</accession>
    <name>Q39S11_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511714.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2745"/>
    <dbReference type="EnsemblBacteria" id="ABB32963">
        <property type="protein sequence ID" value="ABB32963"/>
        <property type="gene ID" value="Gmet_2745"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2745"/>
    <dbReference type="eggNOG" id="COG1555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1364574_0_0_7"/>
    <dbReference type="OrthoDB" id="1948240at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223316" evidence="1">
        <location>
            <begin position="30"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="200" mass="20271" checksum="FE62457017782531" modified="2005-11-22" version="1">MKRGIIRGIAACAGMFSLVALMPLSSAFAAPKAAGVAATAVSGPVDLNSATQTELEKLPGVGAATAKKIMAGRPYTSTSELSTKAKLPAKTVEKIAPLVTVGGGAKAAAKAAAKPAMPAAPKPTMTVPAAKTPAMPKAAAPAKVAVPPAGRGMVWVNPDSKVYHKEGSRWYGKTKKGSYMTESEAIKAGYRAPKQGGKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S14</accession>
    <name>Q39S14_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32960.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511717.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2742"/>
    <dbReference type="EnsemblBacteria" id="ABB32960">
        <property type="protein sequence ID" value="ABB32960"/>
        <property type="gene ID" value="Gmet_2742"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2742"/>
    <dbReference type="HOGENOM" id="CLU_139220_0_0_7"/>
    <dbReference type="OMA" id="TAREDKM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223035" evidence="2">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32960.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="17906" checksum="369FE8E3847A80A3" modified="2012-10-31" version="2">MKRISFVLAAAAVVVSLAGINHGAWAQIGPGDGAGMGAGTGAGTGPKRGAGKMRKMDPERMLQRMEANLGLSAEQKEKIRPILQEQIQEMQAIRNDTTLTRVQKREKMQEMRDKYHARIGEQLTAEQRQKADDMRKKAKERWEKRKNRVKQGPKPTSDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S65</accession>
    <name>Q39S65_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2691"/>
    <dbReference type="EnsemblBacteria" id="ABB32909">
        <property type="protein sequence ID" value="ABB32909"/>
        <property type="gene ID" value="Gmet_2691"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2691"/>
    <dbReference type="HOGENOM" id="CLU_213223_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="49" mass="5555" checksum="880F09FB1E4BB535" modified="2005-11-22" version="1">MREKILGILLVLFVACFVAIIVEEAFLGGRKRRQLQRKARAAASEPEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S87</accession>
    <name>Q39S87_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2669</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511792.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2669"/>
    <dbReference type="EnsemblBacteria" id="ABB32887">
        <property type="protein sequence ID" value="ABB32887"/>
        <property type="gene ID" value="Gmet_2669"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2669"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_3_3_7"/>
    <dbReference type="OMA" id="EYLGMQI"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="60"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="16250" checksum="180EF81064CBE7FE" modified="2005-11-22" version="1">MYEHLYDEPMGEDVALPFELPEWIACAPFEEYLGMTIEEAEGGKARLTMPFQVKHAQGKGLMHGGAVTALADTAVAMAIKSMLPEGSHFVTTELNLKFHAPIHGGTVTARAEAIREDERTIRGVAEVFDEKGVKTATFTSVFRIRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SG1</accession>
    <name>Q39SG1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fatty acyltransferase-like lipase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511867.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2594"/>
    <dbReference type="EnsemblBacteria" id="ABB32813">
        <property type="protein sequence ID" value="ABB32813"/>
        <property type="gene ID" value="Gmet_2594"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2594"/>
    <dbReference type="eggNOG" id="COG3240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015101_3_2_7"/>
    <dbReference type="OMA" id="NSWFLGH"/>
    <dbReference type="OrthoDB" id="1247435at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223342" evidence="1">
        <location>
            <begin position="29"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="320" mass="33276" checksum="23A92FB65D5566FE" modified="2005-11-22" version="1">MKSTRINRWGILGLLLALVLQAPGLATAQTTFGRIVVFGDSLSDPGNLFALEGGANTPPYNTLDQLLIPDKPYARGGHHFSNGATWIEQLSRPLGLAGNTRPAFLGSDTEATNYAVGGARAHDDGINVNLQAQVTAFLNTVGGAAPADALYVVEFGSNDIRDALAAGAAGGPILEGALASVGNNLGALYAAGARKFLVCNAPDISLTPAVLTLDKLSPGAGQFASFLTMTYNSGLNLLLGSLAGLPGIEIVRVDFFQKLHELVATPAAFGLSVVDRACVMPDTPPFACQYPDQFLFWDGTHPTQAVHAIMSQEATSALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SI5</accession>
    <name>Q39SI5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fumarate hydratase class I</fullName>
            <ecNumber evidence="10">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fumB</name>
        <name evidence="13" type="ordered locus">Gmet_2570</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the reversible hydration of fumarate to (S)-malate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>(S)-malate = fumarate + H2O</text>
            <dbReference type="Rhea" id="RHEA:12460"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="4.2.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the class-I fumarase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513464.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2570"/>
    <dbReference type="EnsemblBacteria" id="ABB32789">
        <property type="protein sequence ID" value="ABB32789"/>
        <property type="gene ID" value="Gmet_2570"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2570"/>
    <dbReference type="eggNOG" id="COG1838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1951">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026758_0_0_7"/>
    <dbReference type="OMA" id="AGVLPMC"/>
    <dbReference type="OrthoDB" id="1627779at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004646">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdA-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004647">
        <property type="entry name" value="Fe-S_hydro-lyase_TtdB-typ_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036660">
        <property type="entry name" value="Fe-S_hydroAse_TtdB_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011167">
        <property type="entry name" value="Fe_dep_fumarate_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05681">
        <property type="entry name" value="Fumerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05683">
        <property type="entry name" value="Fumerase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001394">
        <property type="entry name" value="Fe_dep_fumar_hy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117457">
        <property type="entry name" value="SSF117457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00722">
        <property type="entry name" value="ttdA_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00723">
        <property type="entry name" value="ttdB_fumA_fumB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumerase" evidence="11">
        <location>
            <begin position="53"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Fumerase_C" evidence="12">
        <location>
            <begin position="334"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="541" mass="59306" checksum="F9617C1023BEDB39" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SQ7</accession>
    <name>Q39SQ7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Indole-3-glycerol phosphate synthase</fullName>
            <shortName evidence="5">IGPS</shortName>
            <ecNumber evidence="5">4.1.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">trpC</name>
        <name evidence="7" type="ordered locus">Gmet_2494</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TrpC family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.48" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514652.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2494"/>
    <dbReference type="EnsemblBacteria" id="ABB32717">
        <property type="protein sequence ID" value="ABB32717"/>
        <property type="gene ID" value="Gmet_2494"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2494"/>
    <dbReference type="eggNOG" id="COG0134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034247_2_0_7"/>
    <dbReference type="OMA" id="RGPHDLI"/>
    <dbReference type="OrthoDB" id="1789381at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00043"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_A">
        <property type="entry name" value="IGPS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00134_B">
        <property type="entry name" value="IGPS_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="PTHR22854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4 5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="IGPS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="266" mass="29525" checksum="925FD7D2156F5520" modified="2005-11-22" version="1">MPTTPDILKKIVEHKRREVTAARSATPLAELKARIADLEDQPRGFERALRDCHASGWTAVIAEVKKGSPSKGLIRPDFDPLEIAETYEQNGAACLSVLTDEHFFLGNLRYLALIREQVRLPLLRKDFLFDPYQVFEARAAGADAILLIAAMLEREQIEELAGIARELSLDVLLEVHDEPEMETALATNCALIGINNRNLRTFVVDLATTEQLLPMVPADRFVVAESGVNTRADILRLQTAGARGFLIGESLMREEDIGAKLRELLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SS0</accession>
    <name>Q39SS0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2479</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512420.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2479"/>
    <dbReference type="EnsemblBacteria" id="ABB32704">
        <property type="protein sequence ID" value="ABB32704"/>
        <property type="gene ID" value="Gmet_2479"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2479"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_7"/>
    <dbReference type="OMA" id="AQADKMR"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032524">
        <property type="entry name" value="ABC_tran_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16326">
        <property type="entry name" value="ABC_tran_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="4"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="321"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="36"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="353"/>
            <end position="360"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="634" mass="70447" checksum="C0106976787C2E51" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SS4</accession>
    <name>Q39SS4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dihydrofolate synthase/folylpolyglutamate synthase</fullName>
            <ecNumber evidence="7">6.3.2.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Folylpolyglutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="primary">folC</name>
        <name evidence="17" type="ordered locus">Gmet_2475</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="17 18" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Functions in two distinct reactions of the de novo folate biosynthetic pathway. Catalyzes the addition of a glutamate residue to dihydropteroate (7,8-dihydropteroate or H2Pte) to form dihydrofolate (7,8-dihydrofolate monoglutamate or H2Pte-Glu). Also catalyzes successive additions of L-glutamate to tetrahydrofolate or 10-formyltetrahydrofolate or 5,10-methylenetetrahydrofolate, leading to folylpolyglutamate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = (6R)-5,10-methylenetetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:51912"/>
            <dbReference type="Rhea" id="RHEA-COMP:13257"/>
            <dbReference type="Rhea" id="RHEA-COMP:13258"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:136572"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>10-formyltetrahydrofolyl-(gamma-L-Glu)(n) + ATP + L-glutamate = 10-formyltetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:51904"/>
            <dbReference type="Rhea" id="RHEA-COMP:13088"/>
            <dbReference type="Rhea" id="RHEA-COMP:14300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:134413"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>7,8-dihydropteroate + ATP + L-glutamate = 7,8-dihydrofolate + ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:23584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17839"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 7,8-dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.12" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512424.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2475"/>
    <dbReference type="EnsemblBacteria" id="ABB32700">
        <property type="protein sequence ID" value="ABB32700"/>
        <property type="gene ID" value="Gmet_2475"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2475"/>
    <dbReference type="eggNOG" id="COG0285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015869_1_2_7"/>
    <dbReference type="OMA" id="YFEMGTL"/>
    <dbReference type="OrthoDB" id="1232874at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00157"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="PTHR11136"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001563">
        <property type="entry name" value="Folylpolyglu_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="14" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase_M" evidence="16">
        <location>
            <begin position="44"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="15">
        <location>
            <begin position="283"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00000809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00002714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00019357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR001563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="ABB32700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="424" mass="44512" checksum="A8521DE326EE3A57" modified="2005-11-22" version="1">MTYEETLTHIYGLRRFGIKPGLERIATLLERLGNPHERLRVVHVAGTNGKGSTAAFLASILTTGGYRTGLFTSPHLTRFTERIRIDGTEIAEDAVCRIAGLVMAAAPDGTTFFEIVTAMALRYFAEEQVTVAILEAGMGGGSDATSAAFGILSVITPVALDHCVWLGDSLAAIAREKAGIIRPGRPVVLAEQQAEVLDVIKERSTALNSPLVRFGSDFGASWGTDGLDYQGMGRVLSGLTLGIGGRYQAVNAATALAAAELLTTVGYSLADEALRSGISQARWPGRMEYFAGPPRIIFDGAHNPAGALALAESLAGVPRRRLIVVVGVMGDKDAAGILGPLLPLTDEVVAVTPAVERGLSSAELAALCRRLGVSATDGGRVPEGLAMARNMAAVDDLILVCGSLFTVGEARSALLAQRFEPFRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ST8</accession>
    <name>Q39ST8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512439.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32686">
        <property type="protein sequence ID" value="ABB32686"/>
        <property type="gene ID" value="Gmet_2461"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2461"/>
    <dbReference type="HOGENOM" id="CLU_189842_1_1_7"/>
    <dbReference type="OrthoDB" id="2010921at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223078" evidence="2">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="77" mass="8001" checksum="6D0D137930B6B0DF" modified="2005-11-22" version="1">MRARTAAGTLALVMGSVTSALAASGAREDNSGVFVWIFLGFCALIIVAQLVPAVLTMLGMAKGVKESFGERAEVKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T10</accession>
    <name>Q39T10_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl carrier protein phosphodiesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">acpH</name>
        <name evidence="3" type="ordered locus">Gmet_2389</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32614.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514769.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2389"/>
    <dbReference type="DNASU" id="3740427"/>
    <dbReference type="EnsemblBacteria" id="ABB32614">
        <property type="protein sequence ID" value="ABB32614"/>
        <property type="gene ID" value="Gmet_2389"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2389"/>
    <dbReference type="eggNOG" id="COG3124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099370_1_1_7"/>
    <dbReference type="OMA" id="MNFLAHI"/>
    <dbReference type="OrthoDB" id="1398998at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008770">
        <property type="term" value="F:[acyl-carrier-protein] phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007431">
        <property type="entry name" value="ACP_PD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38764">
        <property type="entry name" value="PTHR38764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04336">
        <property type="entry name" value="ACP_PD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011489">
        <property type="entry name" value="DUF479"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32614.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="195" mass="22441" checksum="E8468E25B2D752C0" modified="2012-10-31" version="2">MNFLAHLHLSGDDPDILTGNMMGDFVKGRLEGRFPPRVTLGLELHRRIDSFAAGHPAFQASRRRIEPRFGLYRGVMVDLFYDHFLAANWRQYSAEPIEAFIARSEAVVRSRAVHLPERLVRVVPAIFGEWLPSYAEHEGIDRVLRRMAVRVGRPNPLADGADELLRCYDGLRDDFRRFYPALMTFAEEFIGKVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T94</accession>
    <name>Q39T94_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chemotaxis protein methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cheR40H-1</name>
        <name evidence="8" type="ordered locus">Gmet_2305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366039.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2305"/>
    <dbReference type="EnsemblBacteria" id="ABB32530">
        <property type="protein sequence ID" value="ABB32530"/>
        <property type="gene ID" value="Gmet_2305"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2305"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_0_1_7"/>
    <dbReference type="OMA" id="GKMDVIF"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026024">
        <property type="entry name" value="Chemotaxis_MeTrfase_CheR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000410">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="7">
        <location>
            <begin position="3"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="206"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="225"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000410-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="291" mass="33922" checksum="DEEF85E09483223D" modified="2005-11-22" version="1">MFTLEPEIPLSDEEFRLIRDLIYNHCGLYFDSDATYLLEKRLSKRLQFHHFAGFRDYYHFLKYNRNRDQELSDIMDLLTTNETYFFREAFQLKAFTDEIIPALRAMKMKSGDRTLRIWSAGCSSGEEPYTIAMLLLEMGGFAGWQVEIIGTDICQRVIQQARKGLYGKSSFRVTDDSYIRRYFTEQDGMYRVNDKVRELVTISHLNLLDANRIALLGCMDVIYCRNVIIYFDQLARRKVIDSFYRTLHEGGYLLLGHSESLMNISTAFTLKHFKNDMVYQKPFPGGAGGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TL6</accession>
    <name>Q39TL6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2179"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32408">
        <property type="protein sequence ID" value="ABB32408"/>
        <property type="gene ID" value="Gmet_2179"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2179"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023845_2_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="16"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="355" mass="40244" checksum="056E2311E891630A" modified="2005-11-22" version="1">MSEPRATDIFAEKIVVVTVTYGDRSVYVSRLLERIAQLNIKKIVLVDNNSSCSTKALLDTAASQYHNELIDSITMAENVGSAKAFKAGLIKANQLEGYEYILLLDDDNLPDLDLIEVLESYWTNLAYKHELTALACNRVHLGINERVVAQDNPWLLLGKPNSFLGFHVGEIIRNTCARLFKLPKASLSGRGTNYRTTNFAPYGGLFFHKSLLEVIGYPNEDYVIYADDCEFTYRIPLNGGMILALLDAKIYDMDDRSEMTANIFSIYANIYDKVRLYYTFRNAIHFHLNQHCNNKTIFICNLLIYYAICVCFVLSKFNYSRLRIFYDALLDGISGNIGEADSYTLADVNLSVRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TM5</accession>
    <name>Q39TM5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2170"/>
    <dbReference type="EnsemblBacteria" id="ABB32399">
        <property type="protein sequence ID" value="ABB32399"/>
        <property type="gene ID" value="Gmet_2170"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2170"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_917528_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="303" mass="33812" checksum="9DB90D46DF54997D" modified="2005-11-22" version="1">MNDRQCACCASTSMKSIAPYGAYDHVRCEECGYESFRSPAAAIAAHLYENDTDYCDDLTVASTHEDLILWHHRNAVEFLRSRYPSGNAAVLDVGCFNGFFVKKLLSLGFDAHGIDFNTRAVAYGQKALGLGPRVSSLSVDQCIARGKRFDVITLFEVLEHVPAVRPFLENVLKLLKDDGVIIISTPNNNMCWRPPLDYPPHHLSRFTIASLNACLSGLGMKSLYAAEQMSTYELVRHYLGTFFRAKDRSSLRGGEFKCERITTGLRRGMNRLRGTANLLLTPVDKGLHRLGIRYISQIIVAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TN0</accession>
    <name>Q39TN0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Multicopper oxidase, manganese oxidase family, repeat-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514750.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2165"/>
    <dbReference type="EnsemblBacteria" id="ABB32394">
        <property type="protein sequence ID" value="ABB32394"/>
        <property type="gene ID" value="Gmet_2165"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2165"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009100_4_0_7"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="SSF69318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223263" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="3">
        <location>
            <begin position="710"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1094" mass="115993" checksum="DBBD55A64D40577F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TS0</accession>
    <name>Q39TS0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-cresol methylhydroxylase, alpha-prime subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pcmI</name>
        <name evidence="4" type="ordered locus">Gmet_2125</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513080.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2125"/>
    <dbReference type="EnsemblBacteria" id="ABB32354">
        <property type="protein sequence ID" value="ABB32354"/>
        <property type="gene ID" value="Gmet_2125"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2125"/>
    <dbReference type="eggNOG" id="COG0277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024402_0_1_7"/>
    <dbReference type="OMA" id="TKLGVWL"/>
    <dbReference type="OrthoDB" id="1188552at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016170">
        <property type="entry name" value="Cytok_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-linked_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="SSF55103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="3">
        <location>
            <begin position="46"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="531" mass="59503" checksum="ADCC7A36048B610E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TW6</accession>
    <name>Q39TW6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur cluster-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">bamI</name>
        <name evidence="6" type="ordered locus">Gmet_2079</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514586.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2079"/>
    <dbReference type="EnsemblBacteria" id="ABB32308">
        <property type="protein sequence ID" value="ABB32308"/>
        <property type="gene ID" value="Gmet_2079"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2079"/>
    <dbReference type="eggNOG" id="COG1034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_11_3_7"/>
    <dbReference type="OMA" id="KECFPLC"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="4">
        <location>
            <begin position="2"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="116"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="157"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="218" mass="23732" checksum="7A7EBE26B1E05FF4" modified="2005-11-22" version="1">MSEINLQIDGKEVVATEGMTILDAAKSVGISIPTLCHHEKLEPYGGCRICTVEVEVRGWPKLVAGCIYPVEKGLVVRTRNEKIDKIRKVLLEEMLAHAPDSEELKALAQEYGADRDRFEKHPSFCIHCGLCVRYCAEIKKKNAVGFVDRGSNREISFIPEIAAKECWDCKECFPLCPTSALQAAYVLAGALMTPPEEAHSGGCGCSCSCGSAPEEQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TZ1</accession>
    <name>Q39TZ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl:benzoate coenzyme A transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514049.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2054"/>
    <dbReference type="EnsemblBacteria" id="ABB32283">
        <property type="protein sequence ID" value="ABB32283"/>
        <property type="gene ID" value="Gmet_2054"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2054"/>
    <dbReference type="eggNOG" id="COG0427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030703_1_0_7"/>
    <dbReference type="OMA" id="FFMGANV"/>
    <dbReference type="OrthoDB" id="319106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="282"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="441" mass="48172" checksum="D0B34DD2DB3A2CA0" modified="2005-11-22" version="1">MNVVTLSKKNFQQEYQQKLCTAAEAASIVRSGDHLCFPLGVGEPTLFVRALAARKRELEGVVVNQQHHLCPDYFTEDSAPHIKVNAWFTSHVSREAVQKGWADFVPNHFSEVPKLLSMYWPVEVAGTVVSPMDEYGYFTCSLSVGYTMEAVRKAIQTGGKVVVQVNPQCPRTHGNCHIHISEVTHIIECDEPLKELDIPPISPIEEAIGGYIAEMIDDGSTVQMGWGGIPNAVCQALLKKKDLGIHTELISNGIVDLMLAGAVNNSRKSIHRGKTVGTFALGTRKVFDFMNENPTIEMHPVDYVNDPYVIGQMDNMIAINATIQVDLLGQCCSESFGHLQWSGTGGQADFARGANRSRGGKAFICTASTAKNGTVSCIVPSLMAGSSVTTSKNDVDHVVTEFGVAKLRGQTAKQRAMNLINVAHPDFRGELMEAARRMNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U81</accession>
    <name>Q39U81_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511880.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1964"/>
    <dbReference type="EnsemblBacteria" id="ABB32193">
        <property type="protein sequence ID" value="ABB32193"/>
        <property type="gene ID" value="Gmet_1964"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1964"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_311643_0_0_7"/>
    <dbReference type="OMA" id="AEWNRQP"/>
    <dbReference type="OrthoDB" id="206240at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223275" evidence="1">
        <location>
            <begin position="21"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="944" mass="105912" checksum="1FEA1864352C2B1F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U89</accession>
    <name>Q39U89_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DAHP_snth_FXD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511888.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1956"/>
    <dbReference type="EnsemblBacteria" id="ABB32185">
        <property type="protein sequence ID" value="ABB32185"/>
        <property type="gene ID" value="Gmet_1956"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1956"/>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2770005_0_0_7"/>
    <dbReference type="OMA" id="YLINRDF"/>
    <dbReference type="OrthoDB" id="1999210at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="69" mass="7746" checksum="6CE92620B504649C" modified="2005-11-22" version="1">MLIIMKKSATEEALVEIKEYLISRNFDIHQSTGANRTIIGVIGDTDSLDSAELERMPGVLQVVRIEKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UC3</accession>
    <name>Q39UC3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Menaquinol oxidoreductase complex Cbc3, iron-sulfur cluster-binding subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cbcV</name>
        <name evidence="8" type="ordered locus">Gmet_1922</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511921.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1922"/>
    <dbReference type="EnsemblBacteria" id="ABB32151">
        <property type="protein sequence ID" value="ABB32151"/>
        <property type="gene ID" value="Gmet_1922"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1922"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_0_2_7"/>
    <dbReference type="OMA" id="WGIVDNC"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="44"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="139" mass="14583" checksum="4FBDF494B60777C1" modified="2005-11-22" version="1">MQNASRRKFLGLCLGGLGMAGAVAGAYSVLSYLAPLSDEGTGGKVSFPLTEIPPNGAKFFDFRGTTGVIIRKQNSELVALSAICTHLGCIVQWEQDKQDFLCPCHGGRYNSDGSVISGPPPKPLEKLAITITNGIVTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UE0</accession>
    <name>Q39UE0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate transport system permease protein CysT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysU</name>
        <name evidence="11" type="ordered locus">Gmet_1905</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cell inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1905"/>
    <dbReference type="EnsemblBacteria" id="ABB32134">
        <property type="protein sequence ID" value="ABB32134"/>
        <property type="gene ID" value="Gmet_1905"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1905"/>
    <dbReference type="eggNOG" id="COG0555">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_0_7"/>
    <dbReference type="OMA" id="VFISGNM"/>
    <dbReference type="OrthoDB" id="1584669at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011865">
        <property type="entry name" value="CysT_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF8">
        <property type="entry name" value="PTHR30406:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02139">
        <property type="entry name" value="permease_CysT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="63"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="278" mass="30194" checksum="7EFE89A08A106F3E" modified="2005-11-22" version="1">MMATKSTKRTTVIPGFGPTLGYTLFYLSLMVLLPLSSLVFKTTSLTWPEFLATVTALRVVASYRVTFGAALAAAGVNALFGLLVAWVLVRYRLPGKRLIDALVDLPFALPTAVAGITLSSVYAANGWLGSILEPRGIKVAFTPLGIFVAMIFIGLPFVVRTVQPVLEELEAEIEEAAACLGATRWQTFRRVLFPELLPALLTGFALAFARGVGEYGSIIFIAGNMPMVSEITPLLIITKLEQYDYVGATAIATVMLLFSFLMLLTVNLLQKWSRRHAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UG5</accession>
    <name>Q39UG5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartokinase</fullName>
            <ecNumber evidence="13">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Gmet_1880</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>ATP + L-aspartate = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 14">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 1/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 13">Belongs to the aspartokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="13"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511964.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1880"/>
    <dbReference type="EnsemblBacteria" id="ABB32109">
        <property type="protein sequence ID" value="ABB32109"/>
        <property type="gene ID" value="Gmet_1880"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1880"/>
    <dbReference type="eggNOG" id="COG0527">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_3_2_7"/>
    <dbReference type="OMA" id="DMIVQTI"/>
    <dbReference type="OrthoDB" id="1067792at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00015"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00461"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00462"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04261">
        <property type="entry name" value="AAK_AKii-LysC-BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041740">
        <property type="entry name" value="AKii-LysC-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005260">
        <property type="entry name" value="Asp_kin_monofn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027795">
        <property type="entry name" value="CASTOR_ACT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13840">
        <property type="entry name" value="ACT_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000726">
        <property type="entry name" value="Asp_kin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00656">
        <property type="entry name" value="asp_kin_monofn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="15">
        <location>
            <begin position="264"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="7"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="173"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="209"/>
            <end position="210"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000726-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB32109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="405" mass="43311" checksum="F9F08BEC01A43405" modified="2005-11-22" version="1">MALVVQKYGGTSMGSIERIRNVAKRVAKTYDAGNDMVVVVSAMSGETNKLVALANEVCEFPDNREYDVLVASGEQVSIALLAMCLKSMGYKAKSYHGWQVPIITDSVFSKARIEEIPDAKVRADLKDGTIVVVAGFQGIDKDGNVTTLGRGGSDTSAVAMAAAMKADVCEIYTDVDGVYTTDPNICEDARKIDKISYDEMLELASLGAKVLQIRSVEFAKKYNVDIHVRSSFNDNQGTMVTKEDKDMEAVLVSGIAYDKNEAKIAVLGVPDKPGIAAKILSSLSDANISVDMIVQNVSGGDLTDFTFTVTKADFKKALAITKEIATEIKATGVSADESISKVSIVGVGMRSHAGVATKMFQTLANEGINIQMISTSEIKVSVVIDAKYTELAVRVLHEAFGLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UI8</accession>
    <name>Q39UI8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system pseudopilin OxpG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">oxpG</name>
        <name evidence="3" type="ordered locus">Gmet_1857</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1857"/>
    <dbReference type="EnsemblBacteria" id="ABB32086">
        <property type="protein sequence ID" value="ABB32086"/>
        <property type="gene ID" value="Gmet_1857"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1857"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091705_7_2_7"/>
    <dbReference type="OMA" id="ELIVVMM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000983">
        <property type="entry name" value="Bac_GSPG_pilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00813">
        <property type="entry name" value="BCTERIALGSPG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="140" mass="15570" checksum="1738CFDD8108BDA5" modified="2005-11-22" version="1">MPSFRKMLTKSKGFTLVELMIVVTIIGILATIAVPSYKWSLIKAREAVLRENLYSIRSSIDQFYADQGKYPDTLQDLVDKKYIHGLPTDPFTRKTDSWETIAPPAPTGGADAGKQETGNVYDVHSGSDLVGTDGKPYKEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UJ9</accession>
    <name>Q39UJ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppcE</name>
        <name evidence="6" type="ordered locus">Gmet_1846</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512000.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1846"/>
    <dbReference type="EnsemblBacteria" id="ABB32075">
        <property type="protein sequence ID" value="ABB32075"/>
        <property type="gene ID" value="Gmet_1846"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1846"/>
    <dbReference type="HOGENOM" id="CLU_188310_0_0_7"/>
    <dbReference type="OMA" id="HATCIEC"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002322">
        <property type="entry name" value="Cyt_c_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020942">
        <property type="entry name" value="Cyt_c_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02085">
        <property type="entry name" value="Cytochrom_CIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00609">
        <property type="entry name" value="CYTOCHROMEC3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223147" evidence="4">
        <location>
            <begin position="21"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_CIII" evidence="5">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="90" mass="10064" checksum="D0BA9ED30B4E545F" modified="2005-11-22" version="1">MKRTVPLLIVLMVNVPVVKAADTMIFPAKNGNITFNHKHHTDLLKECKNCHDKTPGRIANFGKDYAHKTCKGCHEVRGTGPTRCGLCHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UL0</accession>
    <name>Q39UL0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA methyltransferase, TrmA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1835</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512011.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1835"/>
    <dbReference type="EnsemblBacteria" id="ABB32064">
        <property type="protein sequence ID" value="ABB32064"/>
        <property type="gene ID" value="Gmet_1835"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1835"/>
    <dbReference type="eggNOG" id="COG2265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014689_7_0_7"/>
    <dbReference type="OMA" id="SIIHVMN"/>
    <dbReference type="OrthoDB" id="1421660at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="PTHR11061"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="6">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="440" mass="48681" checksum="753B6C4B999580B4" modified="2005-11-22" version="1">MTEAVVRIESLAFGGAGFGRVEGKACFVPFTAPDDLARIRLSLVKNSYLEGEIVELLEASPRRVVPLCPVFGICGGCTWQHLSYDDQLEAKERIVGDTLWRFGRIESERVARAVPSDSPYGYRSRVQFKVRWTAGKLQMGFYRRGSHYVVDIPEGCAICNSALNQVLAEIRPVISCFAEPDRIPQVDVAVGDDGVTLAVVHYIGDNRDRARAHFTACRSDLPAVGGLHLQCGRKESIEPLWGDDALTYRFPGDFLPKLPSMTLSFSRGGFSQVNYRQNRELLRAVHRMADLTGEERLLDLFCGNGNFAIPLSRYAMAVVGIEDYGPSLEDARRNAAANGAGKIEFIRSDAAAGVRQLVSREKHYSVVVLDPPRTGAKEAVTEVTSLRPERVVYVSCDPATLGRDLGLFRKSGYDVRECLPVDMFPQTFHIESVTLLSRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UW6</accession>
    <name>Q39UW6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, aldo/keto reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1727</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513376.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1727"/>
    <dbReference type="DNASU" id="3741403"/>
    <dbReference type="EnsemblBacteria" id="ABB31958">
        <property type="protein sequence ID" value="ABB31958"/>
        <property type="gene ID" value="Gmet_1727"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1727"/>
    <dbReference type="eggNOG" id="COG0667">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023205_3_1_7"/>
    <dbReference type="OMA" id="GKGIYGM"/>
    <dbReference type="OrthoDB" id="1054546at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NADP_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42686">
        <property type="entry name" value="PTHR42686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="SSF51430"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="260"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="316" mass="33533" checksum="04BE692C291866A3" modified="2005-11-22" version="1">MNHIMLGTTNISIFPLVFGTLPLGPLQAGLSPSEGGRLIRHALEHGVTMIDTATLYDTYPHVREGIAGWQGDVTIVTKTHANDGPTARAHVEKGLRELGRERLDIVHLHGARVADPFSDRADVLAELLRMKDEGKIGHVGLSSHYICAILKAADHPEIEVVHPLINRTGMGILDGSAAEMAEAIAACARAGKGVYAMKALAGGNLIAEARASLAYVRGLEGVHGVAIGMLSEAEVEANIALFSGNAPEDEVWRQLESRRRKLRIMENFCKGCGGCVEACASGALTVVNGKAVLDEAACILCGYCAASCPEFIIRVV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UW8</accession>
    <name>Y1725_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0178 protein Gmet_1725</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_1725</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0178 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513378.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UW8"/>
    <dbReference type="STRING" id="269799.Gmet_1725"/>
    <dbReference type="EnsemblBacteria" id="ABB31956">
        <property type="protein sequence ID" value="ABB31956"/>
        <property type="gene ID" value="Gmet_1725"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1725"/>
    <dbReference type="eggNOG" id="COG1671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106619_2_1_7"/>
    <dbReference type="OMA" id="CPVKDEI"/>
    <dbReference type="OrthoDB" id="1890924at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00489">
        <property type="entry name" value="UPF0178"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003791">
        <property type="entry name" value="UPF0178"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35146">
        <property type="entry name" value="PTHR35146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02639">
        <property type="entry name" value="DUF188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000241813" description="UPF0178 protein Gmet_1725">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00489"/>
        </source>
    </evidence>
    <sequence length="155" mass="17165" checksum="394CD70AC6B65C4B" modified="2005-11-22" version="1">MKIWIDADACPRVIKEIVFRASERLRIPVCLVANKNLAKHATHLVESIVVGEGFDVADDYIADHAAPEDLVITADIPLAARIVAIGGVALDPRGELYTEENVGERLSMRDLMMELREGGLVQGGPSQFSLTDRQRFASSLDRLLTRLIREMRPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UX6</accession>
    <name>Q39UX6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514137.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1717"/>
    <dbReference type="EnsemblBacteria" id="ABB31948">
        <property type="protein sequence ID" value="ABB31948"/>
        <property type="gene ID" value="Gmet_1717"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1717"/>
    <dbReference type="eggNOG" id="COG1250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_2_0_7"/>
    <dbReference type="OMA" id="SVMEVFY"/>
    <dbReference type="OrthoDB" id="862072at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044248">
        <property type="term" value="P:cellular catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901575">
        <property type="term" value="P:organic substance catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3HCDH_N" evidence="4">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="3HCDH" evidence="3">
        <location>
            <begin position="185"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="281" mass="30777" checksum="D4F8EBE83CA66C68" modified="2005-11-22" version="1">MINKVGVLGAGQMGNGIAHVFAQFGYDVVLYDIAELQLEKAVSTIRKNLERQAKKGGIPESLVGETVGRILTTKNMTDLAGCDFCVEAVTEHEPLKLDIFRKLDDIVQPSAILASNTSSIPITKIASVTKRPDKVIGMHFMNPVPVMKLVEVIRGHASSDVTFRLTAELVARLEKEMAVSQDYPGFIVNRILMPMINEAVFALYEGIATAEDIDKGMKLGTNQPMGPLTLADFIGLDTCLAIMDVLYDGFKDPKYRPCPLLVKMVNAGYLGRKSGRGFYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V03</accession>
    <name>Q39V03_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain iron-sulfur cluster-binding oxidoreductase with cobalamin-binding-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514164.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1690"/>
    <dbReference type="EnsemblBacteria" id="ABB31921">
        <property type="protein sequence ID" value="ABB31921"/>
        <property type="gene ID" value="Gmet_1690"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1690"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021572_5_1_7"/>
    <dbReference type="OMA" id="YFTTNVV"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025274">
        <property type="entry name" value="DUF4070"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13282">
        <property type="entry name" value="DUF4070"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="44"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="154"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="428" mass="48076" checksum="8E7EEB1E7C4EDA8B" modified="2005-11-22" version="1">MKLLFVSPGWPRGRLWGELGFKFPSLSLAALAAVTPESWDVALCDENIEPLDLNSDADLVAITAMTPQAPQAYRIAAAFRARGKRVVMGGFHASNLPEEALQHVDAVVVGEGEVVWPQLLADLERGELQRIYRAATALAMEAIPVARRELFQGKRYLFTNTLQTTRGCPFDCEFCSVTAFYGRRYRKRPVDNVLAELELLRRRNSFAFFVDDNLVADRTYALSLFAGMKGMGFKWLSHAPIDFAHDREFLRAAGEAGCVGMFVGFESLNQDALAAMGKVTNTARSYLEDAQAFRDNGIGILGSFVLGCDNDTPAVFEGLLRFCEEARLEAAIFPILTPYPGTEVRRRLEAEGRIISSDWQDYDMEHVTFLPRGMSVDELQQGYDWLNRSFYSLPSMYRRIFKAHRSVQVFAPMNFGFRSAIRRKGRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V29</accession>
    <name>Q39V29_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Efflux pump membrane transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1664</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 4">Cell inner membrane</location>
            <topology evidence="2 4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511399.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1664"/>
    <dbReference type="EnsemblBacteria" id="ABB31895">
        <property type="protein sequence ID" value="ABB31895"/>
        <property type="gene ID" value="Gmet_1664"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1664"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_0_7"/>
    <dbReference type="OMA" id="QIYYVFA"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004764">
        <property type="entry name" value="HAE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00915">
        <property type="entry name" value="2A0602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="872"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="896"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="972"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="999"/>
            <end position="1026"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1044" mass="113879" checksum="ECA34661E548AAC5" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V40</accession>
    <name>GPMA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2,3-bisphosphoglycerate-dependent phosphoglycerate mutase</fullName>
            <shortName evidence="1">BPG-dependent PGAM</shortName>
            <shortName evidence="1">PGAM</shortName>
            <shortName evidence="1">Phosphoglyceromutase</shortName>
            <shortName evidence="1">dPGM</shortName>
            <ecNumber evidence="1">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpmA</name>
        <name type="ordered locus">Gmet_1653</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511410.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V40"/>
    <dbReference type="SMR" id="Q39V40"/>
    <dbReference type="STRING" id="269799.Gmet_1653"/>
    <dbReference type="EnsemblBacteria" id="ABB31884">
        <property type="protein sequence ID" value="ABB31884"/>
        <property type="gene ID" value="Gmet_1653"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1653"/>
    <dbReference type="eggNOG" id="COG0588">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_1_1_7"/>
    <dbReference type="OMA" id="RMLPYWY"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00186"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046538">
        <property type="term" value="F:2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PTHR11931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000229121" description="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase">
        <location>
            <begin position="1"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="1">
        <location>
            <position position="9"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="21"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="183"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01039"/>
        </source>
    </evidence>
    <sequence length="247" mass="28389" checksum="1FA2E32B6788859A" modified="2005-11-22" version="1">MKKLVLLRHGESVWNRENRFTGWTDVGLSEKGIEEAISAGRTLKEEGFVFDVAYTSVLKRAIKTLWLVLEEMDLMWIPEYRHWRLNERHYGALQGLNKAETAERHGMEQVMIWRRSYDIPPPPLTPDDQRFPGSDPRYASLLPEELPLTESLKDTVARFLPYWHETIAPAVKEGKRVLVTAHGNSLRALVKYLDLVSDSEIVNLNIPTGIPLVYELTDNMTPIRSYYLGDPDDVARASRMVADQIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V58</accession>
    <name>Q39V58_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1635</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511429.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1635"/>
    <dbReference type="EnsemblBacteria" id="ABB31866">
        <property type="protein sequence ID" value="ABB31866"/>
        <property type="gene ID" value="Gmet_1635"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1635"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_367920_0_0_7"/>
    <dbReference type="OMA" id="IAYKEMG"/>
    <dbReference type="OrthoDB" id="1702458at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="597"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="348"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="665" mass="74104" checksum="71B4A8B8422D8BEC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V66</accession>
    <name>RISB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="1">DMRL synthase</shortName>
            <shortName evidence="1">LS</shortName>
            <shortName evidence="1">Lumazine synthase</shortName>
            <ecNumber evidence="1">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ribH</name>
        <name type="ordered locus">Gmet_1627</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) + 2 H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DMRL synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511437.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V66"/>
    <dbReference type="SMR" id="Q39V66"/>
    <dbReference type="STRING" id="269799.Gmet_1627"/>
    <dbReference type="EnsemblBacteria" id="ABB31858">
        <property type="protein sequence ID" value="ABB31858"/>
        <property type="gene ID" value="Gmet_1627"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1627"/>
    <dbReference type="eggNOG" id="COG0054">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089358_1_1_7"/>
    <dbReference type="OMA" id="CQGVTQG"/>
    <dbReference type="OrthoDB" id="1680292at2"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="PTHR21058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="SSF52121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000040424" description="6,7-dimethyl-8-ribityllumazine synthase">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="57"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="83"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="86"/>
            <end position="87"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>5-amino-6-(D-ribitylamino)uracil</name>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>(2S)-2-hydroxy-3-oxobutyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00178"/>
        </source>
    </evidence>
    <sequence length="155" mass="16462" checksum="53573BDD63670235" modified="2005-11-22" version="1">MPRFIEGKLDATGLKFGIIVGRFNSFIGERLLEGALDALVRNGADEATIDVARVPGAFEIPLTAKKMAQTGSYDAIICLGAVIRGSTPHFDYVAAEVSKGVAHVSLETGVPVSFGVLTTDTIEQAVERAGTKAGNKGFDAAMTAIETVRVFREFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VA7</accession>
    <name>Q39VA7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein YlxRQ, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ylxRQ</name>
        <name evidence="3" type="ordered locus">Gmet_1585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511480.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1585"/>
    <dbReference type="EnsemblBacteria" id="ABB31817">
        <property type="protein sequence ID" value="ABB31817"/>
        <property type="gene ID" value="Gmet_1585"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1585"/>
    <dbReference type="eggNOG" id="COG1358">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2740">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091016_2_0_7"/>
    <dbReference type="OMA" id="TCIVTRK"/>
    <dbReference type="OrthoDB" id="1471626at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00279">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007393">
        <property type="entry name" value="DUF448"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="L30e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_L7Ae/L30e/S12e/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037465">
        <property type="entry name" value="YlxR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035931">
        <property type="entry name" value="YlxR-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34215">
        <property type="entry name" value="PTHR34215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04296">
        <property type="entry name" value="YlxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="SSF55315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64376">
        <property type="entry name" value="SSF64376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YlxR" evidence="2">
        <location>
            <begin position="8"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal_L7Ae" evidence="1">
        <location>
            <begin position="91"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="205" mass="22154" checksum="E05BCA0A7D886426" modified="2005-11-22" version="1">MARSEPRRTCLGCRAERGKDELLRYVLDPEGTVVPDLLAKLPGRGAYTCFCRECVEKAATRKQFARAFKGEVRGATSIDLVNMVVSRLEERIASYLALANKAGKIVSGSDMVMEAMRKKNKIGLAIIAGDVSAEIGDKITGVAAREGIPCFRILDKDRIGGLLGKGLRSVVAIEAGGFVPPLVKELQRYGNFLDGGAVDEQDPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VE8</accession>
    <name>Q39VE8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic catabolism-like sigma-54-dependent transcriptional regulator, XylR and V4R domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1542</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511524.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1542"/>
    <dbReference type="EnsemblBacteria" id="ABB31776">
        <property type="protein sequence ID" value="ABB31776"/>
        <property type="gene ID" value="Gmet_1542"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1542"/>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_2_7"/>
    <dbReference type="OMA" id="LENSWES"/>
    <dbReference type="OrthoDB" id="451517at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010523">
        <property type="entry name" value="XylR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06505">
        <property type="entry name" value="XylR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="238"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="586" mass="65083" checksum="F627452C84E98516" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VJ4</accession>
    <name>Q39VJ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, YqgM-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1496</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511571.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1496"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31730">
        <property type="protein sequence ID" value="ABB31730"/>
        <property type="gene ID" value="Gmet_1496"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1496"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_2_0_7"/>
    <dbReference type="OMA" id="FDAEQPF"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="15"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="191"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="374" mass="41513" checksum="0C0E7CA572D66EC8" modified="2005-11-22" version="1">MRIALVTNTFLPLTGGGEFVVHHLGNQWSMQGHDVCVFNSLTAEVAHPEALYKVMRYKIMRGATRFGYHRFPWVNVSTRSLNRQINYFNPDFVSGHFSIPVALYLDNLKPKRIWSITSHGSDIVRNDVNSQRDQYDIDNKLANSLNNASSVIAISNSAKANLLDIGVKPSLIRVIPNGVELNRFKTKANTNIREMFNIPEHKKLVLTVGRNSLVKNLGLGINAVAEIAKSRSDIHYLIVGGGTSQLNETIINRGLRDTVTTCENLAGESLVAAYQQSDIFLSTSNYECCPLVILEAMASGLPIVATQVAGNVDLIDNEVNGLLVGRNNHMHIVNAITMLIADKRLCHSISTTNYDKVSDYSWDTVSRSYLELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VK6</accession>
    <name>Q39VK6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511584.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1484"/>
    <dbReference type="EnsemblBacteria" id="ABB31718">
        <property type="protein sequence ID" value="ABB31718"/>
        <property type="gene ID" value="Gmet_1484"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1484"/>
    <dbReference type="eggNOG" id="COG2301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_347448_0_0_7"/>
    <dbReference type="OMA" id="HELDYTH"/>
    <dbReference type="OrthoDB" id="243762at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="812" mass="90151" checksum="552AAA14660969DB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VL0</accession>
    <name>Q39VL0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511588.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1480"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31714">
        <property type="protein sequence ID" value="ABB31714"/>
        <property type="gene ID" value="Gmet_1480"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1480"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018859_0_0_7"/>
    <dbReference type="OMA" id="TYFPEDR"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="803" mass="90392" checksum="B790BFA6935A04C4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VQ4</accession>
    <name>Q39VQ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511632.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1436"/>
    <dbReference type="EnsemblBacteria" id="ABB31670">
        <property type="protein sequence ID" value="ABB31670"/>
        <property type="gene ID" value="Gmet_1436"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1436"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_606774_0_0_7"/>
    <dbReference type="OMA" id="GYIDWQK"/>
    <dbReference type="OrthoDB" id="1602940at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="448" mass="50843" checksum="0C209343B5B3DC25" modified="2005-11-22" version="1">MNSDRKQRLLTLTPERLADALLELAARDDAADDLVERMIATPWENIERFRKRLAGIKRSRRFIRWGESAAFARELLALLQDVQAGVSDPRTGAELVAAFYECDKGALGNCDDSSGHVGDVFRHDARELFVHYASRCDEKEWLGDLVYKVSRTDDYGVRDALVKCAIDYLPEPVIRTMVKRFQKMADGESDEYHKRHWLGLAESLARQLKDAPLFERTRRASWGSLSTAACVDIARVYLESGDGQTALAWLEKIPVTENFMAEDRDSLLLEVHGRLGNPARQADVAWRIFRRHRSLASLTRLLDVIGSDQRDAVVAGEVAAILGEDRFSPGDAAFLVEVERPDDAENYLLRHADALNGDDYSGLLPLAEAMEQSGRHLCASLLYRALLDSILRRAQTKTYPHGARYLRKLDKLAGTITDWRTFESHDFYKENLRLNHGRKSSFWSRYGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VS9</accession>
    <name>Q39VS9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Threonine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Threonyl-tRNA synthetase</fullName>
            <shortName evidence="12">ThrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 15" type="primary">thrS</name>
        <name evidence="15" type="ordered locus">Gmet_1411</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + H(+) + L-threonyl-tRNA(Thr)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365823.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1411"/>
    <dbReference type="EnsemblBacteria" id="ABB31645">
        <property type="protein sequence ID" value="ABB31645"/>
        <property type="gene ID" value="Gmet_1411"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1411"/>
    <dbReference type="eggNOG" id="COG0441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008554_0_1_7"/>
    <dbReference type="OMA" id="FYYDFAY"/>
    <dbReference type="OrthoDB" id="900765at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="PTHR11451"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="SSF55186"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="7 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="14">
        <location>
            <begin position="9"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="13">
        <location>
            <begin position="252"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Catalytic" evidence="12">
        <location>
            <begin position="252"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB31645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="645" mass="73260" checksum="01F09C4FF1FF5405" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VV3</accession>
    <name>Q39VV3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sec-independent protein translocase protein TatC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">tatC</name>
        <name evidence="6" type="ordered locus">Gmet_1387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TatC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513121.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1387"/>
    <dbReference type="EnsemblBacteria" id="ABB31621">
        <property type="protein sequence ID" value="ABB31621"/>
        <property type="gene ID" value="Gmet_1387"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1387"/>
    <dbReference type="eggNOG" id="COG0805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031942_3_3_7"/>
    <dbReference type="OMA" id="RMLNYSA"/>
    <dbReference type="OrthoDB" id="1848013at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002033">
        <property type="entry name" value="TatC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30371">
        <property type="entry name" value="PTHR30371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00902">
        <property type="entry name" value="TatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01840">
        <property type="entry name" value="TATCFAMILY"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00945">
        <property type="entry name" value="tatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="286" mass="32154" checksum="12896CF32A0CB28D" modified="2005-11-22" version="1">MSEENGKVLPFLEHLAELRKRLIIIIVTVVIGMGLAWNLSGDVLHFVTKPITGKTYLTDIKKQVYQEVGKRWPAAYQQFDLGKEVAAAPKERKLNYSAPLEPFFVQCKISIIAGFILALPIVFYQLWLFIAPGLTRKEKRLVVPFVTVSSISFCVGALFFLVIIWPVIINFSLSYEAEGLNSLFNMSAYVNFCLRLILLFGLIFDLPVLLLLLSRFGVVTYSFLARNRRYALLASSIVAAFHADLITMFVIMVPLYGMYEIGVWLVFLFGKRKPAPAEAEAGGEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VY8</accession>
    <name>Q39VY8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine synthetase</fullName>
            <ecNumber evidence="5">6.3.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">glnA</name>
        <name evidence="7" type="ordered locus">Gmet_1352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + L-glutamate + NH4(+) = ADP + H(+) + L-glutamine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16169"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Oligomer of 12 subunits arranged in the form of two hexagons.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.2" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513156.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1352"/>
    <dbReference type="EnsemblBacteria" id="ABB31586">
        <property type="protein sequence ID" value="ABB31586"/>
        <property type="gene ID" value="Gmet_1352"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1352"/>
    <dbReference type="eggNOG" id="COG0174">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017290_1_2_7"/>
    <dbReference type="OMA" id="VFPWESK"/>
    <dbReference type="OrthoDB" id="416474at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_b-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001637">
        <property type="entry name" value="Gln_synth_I_adenylation_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027302">
        <property type="entry name" value="Gln_synth_N_conserv_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="SSF54368"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="SSF55931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00180">
        <property type="entry name" value="GLNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00182">
        <property type="entry name" value="GLNA_ADENYLATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gln-synt_C" evidence="6">
        <location>
            <begin position="102"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-AMP-tyrosine" evidence="2">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR604809-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="470" mass="52976" checksum="84419F0F87DFC569" modified="2005-11-22" version="1">MTPQEVVSFAKENGALMVDFKFMDFVGTWQHISVPITEFSEDTFEEGQGFDGSSIRGWQPIHASDMILLPDPDTAKMDPFVAVPTLSLICNVFDPITKEDYTRDPRNIARKAEAYLKSTGIGEIAFFGPEAEFFIFDEVRYDSSSNQSFYMVDSVEGAWNSGREEFPNLGYKPRHKEGYFPLSPTDSQNDLRNEMVMELQKVGIRVECQHHEVATGGQAEIDMRFSSLVDMADQLQWFKYVIKNVAYRNSKTVTFMPKPLYGDNGSGMHCHQSIWKNGQNLFAGDKYGGLSQMALWYIGGIIKHAKALCAITNPTTNSYKRLVPGFEAPVNMAYSSRNRSASIRIPMLSTNPKAKRIEYRTPDPSCNGYLAFAAMLMAGLDGIENKIDPGQPLDKDIYGLSPEELKDIPSAPGTLEDALNALRDDHEFLLKGDVFTPDVIEKWIEYKMEAEVNPVRMRPVPLEFALYYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WA1</accession>
    <name>Q39WA1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512132.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1237"/>
    <dbReference type="EnsemblBacteria" id="ABB31473">
        <property type="protein sequence ID" value="ABB31473"/>
        <property type="gene ID" value="Gmet_1237"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1237"/>
    <dbReference type="eggNOG" id="ENOG5033554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1537911_0_0_7"/>
    <dbReference type="OMA" id="AGNWYIV"/>
    <dbReference type="OrthoDB" id="1673559at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="174" mass="19847" checksum="0BB534717B5949D9" modified="2005-11-22" version="1">MSDNNQSTRQQMTEPAVNKDKFAIVTVDDEIRADGLCQSLLKRFYDSLLEGGMDPQEATLVASGADYYVRDFIVGYKHRNLFDERPGIVRQFAGNWYIVNTIEPSIEELAGHLHGVRSFYRFLHGQGLVSGDFLAVMEQECGDGAFYEGRIRSFWEIEGDGYLAWERECSLKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WK0</accession>
    <name>Q39WK0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513400.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1136"/>
    <dbReference type="EnsemblBacteria" id="ABB31374">
        <property type="protein sequence ID" value="ABB31374"/>
        <property type="gene ID" value="Gmet_1136"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1136"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2045934_0_0_7"/>
    <dbReference type="OMA" id="WWRILDA"/>
    <dbReference type="OrthoDB" id="1884225at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="96" mass="10856" checksum="DD0FE8979B974BA2" modified="2005-11-22" version="1">MFQKGSRYEKTDRFAPSADGTTVFAGIRPRAIGPATGVVEHVVKAGDRLDLLARHYYNDDRLWWRIVDANPDFLYGGDMVLEEMEGMVILIPKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WM4</accession>
    <name>Q39WM4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Bidirectional NAD-reducing hydrogenase, diaphorase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hoxF</name>
        <name evidence="13" type="ordered locus">Gmet_1110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513766.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1110"/>
    <dbReference type="EnsemblBacteria" id="ABB31350">
        <property type="protein sequence ID" value="ABB31350"/>
        <property type="gene ID" value="Gmet_1110"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1110"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_7"/>
    <dbReference type="OMA" id="DRMLMEG"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="12">
        <location>
            <begin position="448"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="569" mass="60683" checksum="D1FD7A5764BE8F0B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WN2</accession>
    <name>Q39WN2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding S1 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513758.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1102"/>
    <dbReference type="EnsemblBacteria" id="ABB31342">
        <property type="protein sequence ID" value="ABB31342"/>
        <property type="gene ID" value="Gmet_1102"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1102"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_4_0_7"/>
    <dbReference type="OMA" id="WQQFART"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="115"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="203"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="2">
        <location>
            <begin position="288"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="401" mass="44033" checksum="5FC05B55377115EA" modified="2005-11-22" version="1">MDMDEKDVVETEEESFAELFEKSNSETQRLRPGSKVEGKILKIGAEWVFIDIGKKGEGVMERKELQDAEGNLTVAEGDTITAWFTGSVRNEMRFTTKLGAGAAANAQLEEAHRSGIPVEGFVVKEIKGGFEVRLSGTTRAFCPFSQISLRRAENPAEFVGKHLLFKVTEYSERGRNIVLSHRQILEEEQRVKREALKEVLLEGMTVTGTVTRLADFGAFVDLGGVDGLIPVSEVGWTRVKHVRDVLSVGEQVSVVIKKIDWEAGKISLSLKDTLADPWTTVAEQFPEGSYHTGTVARLAAFGAFVTLAPGIDGLIHISKLGKGKRINHPSDVLKEGETVEVKVDGVDREARRLSLALAEVSRAAEEEEKSVASFRQQATSSSKESMGSFGDLLKAKIEEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WR6</accession>
    <name>Q39WR6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CRISPR-associated integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513244.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1068"/>
    <dbReference type="EnsemblBacteria" id="ABB31308">
        <property type="protein sequence ID" value="ABB31308"/>
        <property type="gene ID" value="Gmet_1068"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1068"/>
    <dbReference type="eggNOG" id="COG1943">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101329_0_0_7"/>
    <dbReference type="OMA" id="FITICCK"/>
    <dbReference type="OrthoDB" id="1547701at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002686">
        <property type="entry name" value="Transposase_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036515">
        <property type="entry name" value="Transposase_17_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM01321">
        <property type="entry name" value="Y1_Tnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143422">
        <property type="entry name" value="SSF143422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Y1_Tnp" evidence="1">
        <location>
            <begin position="21"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="179" mass="20649" checksum="2C37A5DC12C2A59E" modified="2005-11-22" version="1">MTYNPDIHHRRSIRLREYDYSSGGVYFVTMCVQGRECLFGGVVDGVMQLNEAGRMVVGTWHGLAERFPNMTTDEFIVMPNHVHGIMVVQENEIGGGVGAIHELPLQVARRNMVIPKIIGYFKMNTAKQINIMRGSAGIPVWQRNYYERVIRDEREFTSIREYIRCNLLKWADDEENPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WR9</accession>
    <name>Q39WR9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">pre-crRNA processing endonuclease</fullName>
            <ecNumber evidence="2">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cas5d</name>
        <name evidence="3" type="ordered locus">Gmet_1065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRISPR-associated protein Cas5 family. Subtype I-C/Dvulg subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513241.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1065"/>
    <dbReference type="EnsemblBacteria" id="ABB31305">
        <property type="protein sequence ID" value="ABB31305"/>
        <property type="gene ID" value="Gmet_1065"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1065"/>
    <dbReference type="eggNOG" id="ENOG502Z82V">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086014_0_0_7"/>
    <dbReference type="OMA" id="YLGCREF"/>
    <dbReference type="OrthoDB" id="1619114at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021124">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013422">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010155">
        <property type="entry name" value="CRISPR-assoc_prot_Cas5d"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09704">
        <property type="entry name" value="Cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029950">
        <property type="entry name" value="Cas_CT1134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01876">
        <property type="entry name" value="cas_Cas5d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02593">
        <property type="entry name" value="CRISPR_cas5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR029950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="227" mass="26377" checksum="C74D321816935EC3" modified="2005-11-22" version="1">MDMASTKSRMLRLKVWGDNACFTRPEMKVERVSYDVMTPSAARGVLEAILWKPAIRWQVDRIDVLKPIRWESVRRNEVGSVMSPRTNGLFIEEQRQQRAGLFLRDVAYTIHAWFEMTVPPDERNNVIKFQEMFICRASKGKCFNQPYLGTREFSAGFELIPHDQSLPEPIVETRDLGFMLYDLCHDTSRDEGHVHTCTDGCRPSFFRAALKDGRMMVPARDSEEVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WT8</accession>
    <name>Q39WT8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ethanol dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1046</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513219.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1046"/>
    <dbReference type="EnsemblBacteria" id="ABB31286">
        <property type="protein sequence ID" value="ABB31286"/>
        <property type="gene ID" value="Gmet_1046"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1046"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_7"/>
    <dbReference type="OMA" id="LPHTAHY"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="13"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="387" mass="40371" checksum="6EC44ADE9E53E4AA" modified="2005-11-22" version="1">MALADQTFGFFIPTVTLMGVGSSKETGAQVKALGARKALLVTDKGISAMGMADQIKQQVEAAGVAVVIFDGAEPNPTDTNVHDGVKVYQENGCDSIISLGGGSSHDCAKGVGLVIGNGGHIRDFEGVNKSTKPMPPFVAINTTAGTASEMTRFCIITNTDTHVKMAIVDWRCTPNIAINDPVLMLGKPAPLTAATGMDALTHAVEAYVSTIATPITDACALQAIKLIAEYLSPAVANGDNLEARDRMAYAEYLAGMAFNNASLGYVHSMAHQLGGFYNLPHGVCNAILLPAVSEFNAIACPKRYADIAVALGEDITGLAPLDAAAKAIAAIRKLSAAIGIPAGLKELNVKEEDLKVMAENAKKDACQLTNPRKATLEQVIGIFKAAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WU0</accession>
    <name>Q39WU0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Molybdopterin biosynthesis sulfur carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">moaD</name>
        <name evidence="1" type="ordered locus">Gmet_1044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513217.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1044"/>
    <dbReference type="EnsemblBacteria" id="ABB31284">
        <property type="protein sequence ID" value="ABB31284"/>
        <property type="gene ID" value="Gmet_1044"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1044"/>
    <dbReference type="eggNOG" id="COG1977">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114601_5_3_7"/>
    <dbReference type="OMA" id="FAQYREG"/>
    <dbReference type="OrthoDB" id="1995573at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="74" mass="8120" checksum="95900F9FF8E908F7" modified="2005-11-22" version="1">MEITVKLFAMFRVGRFAAGTYKYRDGITPADIAGELKIPEKDVGIVLVNSRHAKLDHRLFEGDTLSLFPLVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WV8</accession>
    <name>Q39WV8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5666 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1025</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31266.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513196.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1025"/>
    <dbReference type="EnsemblBacteria" id="ABB31266">
        <property type="protein sequence ID" value="ABB31266"/>
        <property type="gene ID" value="Gmet_1025"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1025"/>
    <dbReference type="eggNOG" id="ENOG5030XPS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2219354_0_0_7"/>
    <dbReference type="OMA" id="DGHHAGK"/>
    <dbReference type="OrthoDB" id="2023428at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043724">
        <property type="entry name" value="DUF5666"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18914">
        <property type="entry name" value="DUF5666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223391" description="DUF5666 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5666" evidence="2">
        <location>
            <begin position="42"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31266.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="106" mass="11253" checksum="8F88B6A77006D948" modified="2012-10-31" version="2">MKNFIAIVALGLFVALAAGVTFASEHGRHEGKEAGQYESTIYGTVRSLPSGMIGVWNVNGREVNVTKATSIKEKHGKAEVGAYVEVDGHHAGKVFSAGKIEVKRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WW3</accession>
    <name>Q39WW3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Respiratory nitrate reductase, cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">narC-2</name>
        <name evidence="8" type="ordered locus">Gmet_1019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513190.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1019"/>
    <dbReference type="EnsemblBacteria" id="ABB31261">
        <property type="protein sequence ID" value="ABB31261"/>
        <property type="gene ID" value="Gmet_1019"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1019"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073827_0_0_7"/>
    <dbReference type="OrthoDB" id="1469969at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="44"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="154"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="296" mass="30743" checksum="B51FA64605A0C9BB" modified="2005-11-22" version="1">MKTVIIGGVAASAACAMTRRMLVAMVIALLASAMHPHQGSSKERAEGDGKALFQAKCSPCHTIGGGRLVGPDLKGVTARRDRGWLERFISAPDKVLASGDPVAARLFQESNKVPMPNLGLGQDQVNVLLNYLSAPEGISPSKAEPPASPVQEEGDPSRGEKFFTGALPFAQGGTPCIACHQVAGIPPLGGGALGPDLTTIVATFGDTALSSALATLPFPTMKPIFGDHPLTRGEQGDLLAFFRKVAPRPPVTATTRIALWAGGGFLVLLLLTGALGRRRLGSVRGTLVDEANRAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WW6</accession>
    <name>Q39WW6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Aconitate hydratase</fullName>
            <shortName evidence="9">Aconitase</shortName>
            <ecNumber evidence="9">4.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">acnA</name>
        <name evidence="12" type="ordered locus">Gmet_1016</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <text evidence="9">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513187.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1016"/>
    <dbReference type="EnsemblBacteria" id="ABB31258">
        <property type="protein sequence ID" value="ABB31258"/>
        <property type="gene ID" value="Gmet_1016"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1016"/>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013476_2_1_7"/>
    <dbReference type="OMA" id="NGGIMQY"/>
    <dbReference type="OrthoDB" id="363064at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01580">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044137">
        <property type="entry name" value="AcnA_IRP_Swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006249">
        <property type="entry name" value="Aconitase/IRP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11670">
        <property type="entry name" value="PTHR11670"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01341">
        <property type="entry name" value="aconitase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 9" id="KW-0408">Iron</keyword>
    <keyword evidence="6 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="10">
        <location>
            <begin position="79"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="11">
        <location>
            <begin position="731"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB31258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="937" mass="102182" checksum="51097322F5C6D65E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WZ0</accession>
    <name>Q39WZ0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 10">Cysteine desulfurase</fullName>
            <ecNumber evidence="6 10">2.8.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Nitrogenase metalloclusters biosynthesis protein NifS</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">nifS-1</name>
        <name evidence="12" type="ordered locus">Gmet_0992</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Seems to participate in the biosynthesis of the nitrogenase metalloclusters by providing the inorganic sulfur required for the Fe-S core formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="6 10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365756.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0992"/>
    <dbReference type="EnsemblBacteria" id="ABB31234">
        <property type="protein sequence ID" value="ABB31234"/>
        <property type="gene ID" value="Gmet_0992"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0992"/>
    <dbReference type="eggNOG" id="COG1104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_0_0_7"/>
    <dbReference type="OMA" id="APHIINF"/>
    <dbReference type="OrthoDB" id="839689at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017772">
        <property type="entry name" value="Cys_deSase_NifS_bac/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03402">
        <property type="entry name" value="FeS_nifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="11">
        <location>
            <begin position="4"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB31234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="391" mass="43138" checksum="BCAC35A94077CE91" modified="2005-11-22" version="1">MKEIYMDNNATTKVDEAVFEEMRPYFCDLYGNPSSMHFFGGQVQKKVDEARNRVANLLGASPEEIVFTACGTESDNAAIRSAIEVHPERRHIITTRVEHPAVLTLCRNLSKRGYRVTELNVDGEGRLDLNELRAAVDEDTAIVSVMWANNETGVVFPIEEVGKIVKEKGKGAFFHTDAVQAVGKIPINMAASTVDMLSISGHKLHAPKGIGVLYVRKGVPFRPFMVGGHQEHNRRAGTENTAAIIALGKACELAGQWMEDENTRVKAMRDRLQTTLLELIPRSRINGGQAERLPNTLSIAFEFVEGEAILMLLSEKGICASSGSACTSGSLEPSHVLRAMGVPFTCAHGSIRFSLSRFNTDEDIETIIRELPPVVRRLREMSPFGREFLNA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X04</accession>
    <name>AROB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate synthase</fullName>
            <shortName evidence="1">DHQS</shortName>
            <ecNumber evidence="1">4.2.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroB</name>
        <name type="ordered locus">Gmet_0978</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514373.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X04"/>
    <dbReference type="SMR" id="Q39X04"/>
    <dbReference type="STRING" id="269799.Gmet_0978"/>
    <dbReference type="EnsemblBacteria" id="ABB31220">
        <property type="protein sequence ID" value="ABB31220"/>
        <property type="gene ID" value="Gmet_0978"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0978"/>
    <dbReference type="eggNOG" id="COG0337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001201_0_2_7"/>
    <dbReference type="OMA" id="IKMAVCF"/>
    <dbReference type="OrthoDB" id="1677032at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00110">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030963">
        <property type="entry name" value="DHQ_synth_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001455">
        <property type="entry name" value="DHQ_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000231089" description="3-dehydroquinate synthase">
        <location>
            <begin position="1"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="72"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="106"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="130"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="170"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00110"/>
        </source>
    </evidence>
    <sequence length="360" mass="38119" checksum="748FA25E49CC52C1" modified="2005-11-22" version="1">METLTVGLGDRSYTIRGGSGILPGIGAFCRELGLGRIVAVVTNTTVGPLYYGPVADSLAAAGFSPLRVELPDGEEFKTSATMNIIYDALIDGGLTRDSFIVALGGGVVGDMAGFAAATYLRGIPFVQVPTTLLAQVDSSVGGKTGINHPRGKNLIGAFYQPRAVVIDVETLTTLPEREYLAGMAEVVKYGVVLDPQLFAEVERNITPILARDRDVLTRIIMACCAIKASVVEKDERESGLRAVLNYGHTLGHAVETLAGYGTFLHGEAVAIGMVQAAKLAEHRGEATADDTGRLRALLESLKLPVELPVFAAEAYREVLLRDKKARDTGLSFVLNNGIGGFSIVRLRDLSEVIDVCGIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X17</accession>
    <name>Q39X17_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus minor pilin PilW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilW-2</name>
        <name evidence="2" type="ordered locus">Gmet_0965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514359.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0965"/>
    <dbReference type="EnsemblBacteria" id="ABB31207">
        <property type="protein sequence ID" value="ABB31207"/>
        <property type="gene ID" value="Gmet_0965"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0965"/>
    <dbReference type="eggNOG" id="COG4966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1218358_0_0_7"/>
    <dbReference type="OrthoDB" id="1824962at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="227" mass="24023" checksum="B72B56FD811B61AE" modified="2005-11-22" version="1">MSQSSLNGRRGFTLVELLVTMFVAALVIMAATTTFIVQNKMASVQSATSDVQISGQMVMDLLERDIRMAGFGVSKATGLAASDNALANDATCSVGTDAVQIRYSTAISSGSTRGSRAYNYYVSKDPANPGLMRQDLLPGGTTDPIASNVEDLQISGVYDDDGSAVNLGNVDPARPMRVTLQILLKSQARDPDSTTTPPTIGNGIARAADGYRRRTYSVTVSPRNFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X52</accession>
    <name>Q39X52_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">omcZ</name>
        <name evidence="3" type="ordered locus">Gmet_0930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513960.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0930"/>
    <dbReference type="EnsemblBacteria" id="ABB31172">
        <property type="protein sequence ID" value="ABB31172"/>
        <property type="gene ID" value="Gmet_0930"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0930"/>
    <dbReference type="HOGENOM" id="CLU_577171_0_0_7"/>
    <dbReference type="OMA" id="IRACEAC"/>
    <dbReference type="OrthoDB" id="1300135at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223381" evidence="2">
        <location>
            <begin position="21"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="489" mass="50445" checksum="BA148AB558A4F530" modified="2005-11-22" version="1">MKKKILLSAGLAVTAILGFAAVNWAVVPPPPVNQNGGIYDTTFSALTRADCLQAAPCHVSDTVVVPRHHNLTLPPRQLSCYGDPTANPVTGCHQLVPDGAGGFTFADFRDCLRCHSKTPHHITTQAQQQDCKFCHGSFIDNPLDGHTIPTYAKSSVTPETKWRGNNPTSPQNYGGCAACHQAAVASPTVGPKDIKSNADNHHGTGLGAPTSTTGQPIQVGDCTWCHGGVPGDVNFLDIRTCERCHGIKSLHNIENPSGAGPNGSTLGTNVVPGAMPLGYGHIGADFDCWGCHGTFKKYATDPSPAGAVVPFVSDLSTRVLIANQSNALTITGGSFTNQSNGVDFTSSVTLTNGSVTVNVQPTSITVSEIQVNIPALPVGTYDLLVVKGDKQSNLTRVAVLPLLTIKSASVSGGTVTITGSGFGDAPATDVNTGLGLFAADGSQIPVSFWGNGKIVGSSTAVKAGSTVTVKTLYGPTSALVTGAGKKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X54</accession>
    <name>Q39X54_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidoglycan transpeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mrdA</name>
        <name evidence="6" type="ordered locus">Gmet_0928</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513958.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0928"/>
    <dbReference type="EnsemblBacteria" id="ABB31170">
        <property type="protein sequence ID" value="ABB31170"/>
        <property type="gene ID" value="Gmet_0928"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0928"/>
    <dbReference type="eggNOG" id="COG0768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009289_1_2_7"/>
    <dbReference type="OMA" id="SCDTYYY"/>
    <dbReference type="OrthoDB" id="423699at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005311">
        <property type="entry name" value="PBP_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036138">
        <property type="entry name" value="PBP_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017790">
        <property type="entry name" value="Penicillin-binding_protein_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03717">
        <property type="entry name" value="PBP_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56519">
        <property type="entry name" value="SSF56519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03423">
        <property type="entry name" value="pbp2_mrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_dimer" evidence="5">
        <location>
            <begin position="63"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="4">
        <location>
            <begin position="265"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="620"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="643" mass="70821" checksum="6886BB5CA6A68561" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XF6</accession>
    <name>Q39XF6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514413.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0826"/>
    <dbReference type="EnsemblBacteria" id="ABB31068">
        <property type="protein sequence ID" value="ABB31068"/>
        <property type="gene ID" value="Gmet_0826"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0826"/>
    <dbReference type="eggNOG" id="ENOG5033ND1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_635792_0_0_7"/>
    <dbReference type="OMA" id="LHAYGWG"/>
    <dbReference type="OrthoDB" id="1332813at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223413" evidence="1">
        <location>
            <begin position="27"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="427" mass="47601" checksum="70CF4D0CDD5EE441" modified="2005-11-22" version="1">MKLHQGFTLGVTILAALLAASAPGSAADLGITSDTIVRLYERNESGGRQRSLLPVYEFLRFDYTVPKTPGLSLHAYGWGRANLRDDFGNADGTTDGELLYAYLDYLDPKNRDYQVRLGRQYIFEGVMRESIDGVYVKTDLVPTVTASAYAGFPVNLQDVKGMGGDWIYGARVAQGIPGRYDVALAYKHTGNDGSTDEQLLGADATLLLPANITLLGHTTWNLVTGGLGEQSYELRLPFKAFELRPFYQHYRYEDFLNRKSGGATPFLYTSQFGEQVDIAGTEAFWYPAENIEFGARYKHYEYGKRYGSADMYTVLAAVRRKIFSEAGVEFGRVEGDIAQNRYYLGRAYVYWDVAPAFVTADVVYVNYDDGNVWSMYRKDSAFFASVGGGSKFLGKALTVKLSLDYSQDPYFDKDYRGTLAASYAFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XG2</accession>
    <name>Q39XG2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514407.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0820"/>
    <dbReference type="EnsemblBacteria" id="ABB31062">
        <property type="protein sequence ID" value="ABB31062"/>
        <property type="gene ID" value="Gmet_0820"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0820"/>
    <dbReference type="eggNOG" id="COG5519">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2478936_0_0_7"/>
    <dbReference type="OMA" id="IYLTNDA"/>
    <dbReference type="OrthoDB" id="1853553at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="87" mass="10161" checksum="2EE6A74968B4C9C9" modified="2005-11-22" version="1">MIYLTTDQFDQAVYFDLRKTEHPRRAGGQEHILHGLLGNGVSEVPVTIRSWRDWTDVNFGKGDLFSFVDERTIRRMLGQVAREMELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XP5</accession>
    <name>Q39XP5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Type IV pilus assembly protein PilY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pilY1-1</name>
        <name evidence="7" type="ordered locus">Gmet_0737</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PilY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514454.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0737"/>
    <dbReference type="EnsemblBacteria" id="ABB30979">
        <property type="protein sequence ID" value="ABB30979"/>
        <property type="gene ID" value="Gmet_0737"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0737"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001890_3_0_7"/>
    <dbReference type="OMA" id="YRITTHA"/>
    <dbReference type="OrthoDB" id="165468at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008707">
        <property type="entry name" value="PilC_beta_prop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05567">
        <property type="entry name" value="Neisseria_PilC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0281">Fimbrium</keyword>
    <keyword evidence="2" id="KW-1029">Fimbrium biogenesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223424" evidence="5">
        <location>
            <begin position="26"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="Neisseria_PilC" evidence="6">
        <location>
            <begin position="500"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="Neisseria_PilC" evidence="6">
        <location>
            <begin position="767"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="931"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="991" mass="106052" checksum="74BF24B3A714A8F8" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XW5</accession>
    <name>Q39XW5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514275.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0667"/>
    <dbReference type="EnsemblBacteria" id="ABB30909">
        <property type="protein sequence ID" value="ABB30909"/>
        <property type="gene ID" value="Gmet_0667"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0667"/>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095256_0_1_7"/>
    <dbReference type="OMA" id="PQAYFEV"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="153"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="191" mass="21354" checksum="EEFA78A441A674C1" modified="2005-11-22" version="1">MSSVKGTKTEQNLLKSFAGESQARNRYTYFAAAAKKEGYVQIADIFEETANQEKEHAKRFFKFLEGGDLEITACFPAGRIGTTAENLLAAATGEHEEHTVLYPGFAQVAQEEGFPAIAAAWRAISVAEKQHEKRYRDLLANVEAKRVFTREAEVVWRCRNCGYLHTATGAPEQCPACVHPKDHFELLGENW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y51</accession>
    <name>Q39Y51_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512278.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0580"/>
    <dbReference type="EnsemblBacteria" id="ABB30823">
        <property type="protein sequence ID" value="ABB30823"/>
        <property type="gene ID" value="Gmet_0580"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0580"/>
    <dbReference type="eggNOG" id="COG3880">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013249_0_0_7"/>
    <dbReference type="OMA" id="NICHYLT"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010176">
        <property type="entry name" value="C4xCH_C2xCH_motif_GEOSU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09698">
        <property type="entry name" value="GSu_C4xC__C2xCH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01904">
        <property type="entry name" value="GSu_C4xC__C2xCH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="869" mass="89577" checksum="B6DDEA8591D4A554" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z24</accession>
    <name>Q39Z24_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0255</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:13681"/>
            <dbReference type="Rhea" id="RHEA-COMP:11369"/>
            <dbReference type="Rhea" id="RHEA-COMP:11370"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:85452"/>
            <dbReference type="ChEBI" id="CHEBI:85454"/>
            <dbReference type="EC" id="2.1.1.37"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30500.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0255"/>
    <dbReference type="REBASE" id="11545">
        <property type="entry name" value="M.GmeORF255P"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30500">
        <property type="protein sequence ID" value="ABB30500"/>
        <property type="gene ID" value="Gmet_0255"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0255"/>
    <dbReference type="eggNOG" id="COG0270">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049101_0_0_7"/>
    <dbReference type="OMA" id="VMDIIHP"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0680">Restriction system</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 7" id="KW-0808">Transferase</keyword>
    <feature type="active site" evidence="6">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30500.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="311" mass="34138" checksum="933700029A1BF04D" modified="2012-10-31" version="2">MKTAAPLRTLELFCGIGGFSAAVEGGNVRIVGAFDQDPAALDTYRLNFPGHGARKVDLERVSAWELTAGGVDLWWLSPPCQPYCERGARRDLADPRARSLVHILELLERIPDDLLPRHLALENVAGFVGSEGHGLLTEVLTSRGFQVRERFLCPTELGAPMRRPRYYLAASRDEMRPLVAPEPRPLRPLAGYLDRRFDGEVPTELLLSPDVVARFGGALPILDSGDGSACATCFTAGYGRSITSAGSYLQCASGVRHFSPEEIVRFMAFPEGFRFPDEVPLRKRWHLIGNSLSVAAVREVLRVFPSLGLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z27</accession>
    <name>Q39Z27_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome c oxidase subunit 2</fullName>
            <ecNumber evidence="17">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">coxB</name>
        <name evidence="22" type="ordered locus">Gmet_0252</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14 17">Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="17">Binds a copper A center.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the cytochrome c oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="17"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513568.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0252"/>
    <dbReference type="EnsemblBacteria" id="ABB30497">
        <property type="protein sequence ID" value="ABB30497"/>
        <property type="gene ID" value="Gmet_0252"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0252"/>
    <dbReference type="eggNOG" id="COG1622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036876_1_0_7"/>
    <dbReference type="OMA" id="LEWWLIG"/>
    <dbReference type="OrthoDB" id="1654242at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045187">
        <property type="entry name" value="CcO_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002429">
        <property type="entry name" value="CcO_II-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001505">
        <property type="entry name" value="Copper_CuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014222">
        <property type="entry name" value="Cyt_c_oxidase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011759">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036257">
        <property type="entry name" value="Cyt_c_oxidase_su2_TM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22888">
        <property type="entry name" value="PTHR22888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00116">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02790">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81464">
        <property type="entry name" value="SSF81464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02866">
        <property type="entry name" value="CoxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00078">
        <property type="entry name" value="COX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50857">
        <property type="entry name" value="COX2_CUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50999">
        <property type="entry name" value="COX2_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0186">Copper</keyword>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4 15" id="KW-0349">Heme</keyword>
    <keyword evidence="11 15" id="KW-0408">Iron</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 16 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_TM" evidence="20">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="COX2_CUA" evidence="19">
        <location>
            <begin position="90"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="21">
        <location>
            <begin position="205"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ABB30497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="302" mass="33477" checksum="7AB4706A3F63B3E3" modified="2005-11-22" version="1">MDPNLYTTTRAVDPVFIWIFGVSLVLLLGITATMVGFVIRYRRSRAPEPTSQAASNIWLEIIWTALPTIIVMAMFYYGWAGYLTLRNVPKDALEVTATARMWSWSFTYANGKTSPTLYVPVGKPVLVHLVSEDVIHGFYVPAFRVKHDVVPGMKNHVWFVADKPGTYDLFCSVYCGLGHSGMVSTVVAVPEAEFQAWLAKAEKEENQGGGRALLEKNGCLGCHSLDGSRKVGPSFKGIWGRNVTVMTGGAERTITVDEEYVKRSIREPGADVVKGYPPVMPPYSALSDKDIEEIMDFLKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZB3</accession>
    <name>Q39ZB3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512751.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0164"/>
    <dbReference type="EnsemblBacteria" id="ABB30411">
        <property type="protein sequence ID" value="ABB30411"/>
        <property type="gene ID" value="Gmet_0164"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0164"/>
    <dbReference type="eggNOG" id="COG4564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2699436_0_0_7"/>
    <dbReference type="OrthoDB" id="1812977at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="73" mass="8488" checksum="BC3DE33D62C026C1" modified="2005-11-22" version="1">MPKMKQWLTITKLYNVWMLRHLRAQAHAHARLRQGTISEVSCMWPRPGSTDPVPKVSFVTKVDDQVCTVGYYK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZC5</accession>
    <name>NUOA1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit A 1</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit A 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit A 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NUO1 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoA1</name>
        <name type="ordered locus">Gmet_0152</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 3 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512739.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZC5"/>
    <dbReference type="SMR" id="Q39ZC5"/>
    <dbReference type="STRING" id="269799.Gmet_0152"/>
    <dbReference type="EnsemblBacteria" id="ABB30399">
        <property type="protein sequence ID" value="ABB30399"/>
        <property type="gene ID" value="Gmet_0152"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0152"/>
    <dbReference type="eggNOG" id="COG0838">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119549_2_0_7"/>
    <dbReference type="OMA" id="CGVDPVG"/>
    <dbReference type="OrthoDB" id="1748431at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01394">
        <property type="entry name" value="NDH1_NuoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023043">
        <property type="entry name" value="NAD(P)H_OxRDtase_bac/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000440">
        <property type="entry name" value="NADH_UbQ/plastoQ_OxRdtase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038430">
        <property type="entry name" value="NDAH_ubi_oxred_su3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11058">
        <property type="entry name" value="PTHR11058"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00507">
        <property type="entry name" value="Oxidored_q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000362691" description="NADH-quinone oxidoreductase subunit A 1">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01394"/>
        </source>
    </evidence>
    <sequence length="138" mass="15461" checksum="7C4ACE08AC3E7E67" modified="2005-11-22" version="1">MQQTTVANHSLFPTLPPEFLPLALYTVAATVLIGVLLLAAWWLGAKTTNRNKELPYESGVIPTGSARLAYPVPFYLIAIFFIVFDVEAAFIFAWATAWRELGLAGLIHITFFIVILLLGLVWLWMKGGLDWGPSRERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZG9</accession>
    <name>Q39ZG9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">D-isomer-specific 2-hydroxyacid dehydrogenase, NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514111.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0106"/>
    <dbReference type="DNASU" id="3738885"/>
    <dbReference type="EnsemblBacteria" id="ABB30355">
        <property type="protein sequence ID" value="ABB30355"/>
        <property type="gene ID" value="Gmet_0106"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0106"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_0_7"/>
    <dbReference type="OMA" id="VEGMVEY"/>
    <dbReference type="OrthoDB" id="1435073at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh_C" evidence="1">
        <location>
            <begin position="109"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="314" mass="34812" checksum="EFD2DF3AA5B3903E" modified="2005-11-22" version="1">MKISNLLIHLHNNIDAFTLKPRHVEQIRQALPEVAITVSASDSDFMDRLPDAEYALVWVFKPEWYATAPRLKALFTPAAGRDWVAADPSGRVMTCHGSFHGRIMRESLLSMMLYFNRRLGQSLEDQGRRMWGRPDYSGCVGLFSQRVMIVGLGALGQSMAELLKAFGAHVTGVKRNPESFAGSPCVDRVISFDALEEALPEADHVVLLLPGGTATDGIFTARHFNAMRPGAYLYNLGRGNCYREEDLVAALEDGRLAGAGLDVFAEEPLPASSPLWEQRNVLITPHSSAISREYLDLFIQEWLETLRKGAPQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZI0</accession>
    <name>Q39ZI0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7 8" key="3">
        <citation type="journal article" date="2016" name="ACS Chem. Biol." volume="11" first="1729" last="1736">
            <title>Structural Basis of Substrate Specificity in Geobacter metallireducens SMUG1.</title>
            <authorList>
                <person name="Zhang Z."/>
                <person name="Shen J."/>
                <person name="Yang Y."/>
                <person name="Li J."/>
                <person name="Cao W."/>
                <person name="Xie W."/>
            </authorList>
            <dbReference type="PubMed" id="27071000"/>
            <dbReference type="DOI" id="10.1021/acschembio.6b00164"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514100.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="5H93">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.18 A"/>
        <property type="chains" value="A/B/C/D=1-237"/>
    </dbReference>
    <dbReference type="PDB" id="5H98">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.04 A"/>
        <property type="chains" value="A/B=1-237"/>
    </dbReference>
    <dbReference type="PDB" id="5H99">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B=1-237"/>
    </dbReference>
    <dbReference type="PDB" id="5H9I">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.50 A"/>
        <property type="chains" value="A=1-237"/>
    </dbReference>
    <dbReference type="PDBsum" id="5H93"/>
    <dbReference type="PDBsum" id="5H98"/>
    <dbReference type="PDBsum" id="5H99"/>
    <dbReference type="PDBsum" id="5H9I"/>
    <dbReference type="SMR" id="Q39ZI0"/>
    <dbReference type="STRING" id="269799.Gmet_0095"/>
    <dbReference type="EnsemblBacteria" id="ABB30344">
        <property type="protein sequence ID" value="ABB30344"/>
        <property type="gene ID" value="Gmet_0095"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0095"/>
    <dbReference type="eggNOG" id="COG1573">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071760_2_0_7"/>
    <dbReference type="OMA" id="VANYCPL"/>
    <dbReference type="OrthoDB" id="960492at2"/>
    <dbReference type="BRENDA" id="3.2.2.27">
        <property type="organism ID" value="2414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017065">
        <property type="term" value="F:single-strand selective uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19374">
        <property type="entry name" value="UDG-F3_SMUG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039134">
        <property type="entry name" value="SMUG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13235">
        <property type="entry name" value="PTHR13235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="SSF52141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="5H93"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="5H98"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="5H99"/>
        </source>
    </evidence>
    <sequence length="237" mass="25804" checksum="6D35276CB3450999" modified="2005-11-22" version="1">MTGLAAISDALAADLAGLSFSSPVAHVYNPLLYAREPHVAYLSRFGSPPKEVLFVGMNPGPWGMAQTGVPFGEVAVVTEWLGINGTVTRPAGEHPKKRVDGFACRRSEVSGRRLWGFIRERFGTPERFFARFFVANYCPLLFLTAEGGNITPDKLRRGEQEPLFAACDLALRRTVVLLRPRVVIGVGAFAEARCHEALEGFDVEVGRIIHPSPASPAANRDWAGTALRQLAELGVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZJ2</accession>
    <name>Q39ZJ2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PHB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514780.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0083"/>
    <dbReference type="EnsemblBacteria" id="ABB30332">
        <property type="protein sequence ID" value="ABB30332"/>
        <property type="gene ID" value="Gmet_0083"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0083"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016994_0_0_7"/>
    <dbReference type="OMA" id="PGKYAFN"/>
    <dbReference type="OrthoDB" id="225351at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="2">
        <location>
            <begin position="458"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="830" mass="89818" checksum="540E78A296112079" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZM5</accession>
    <name>Q39ZM5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365620.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0050"/>
    <dbReference type="EnsemblBacteria" id="ABB30299">
        <property type="protein sequence ID" value="ABB30299"/>
        <property type="gene ID" value="Gmet_0050"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0050"/>
    <dbReference type="eggNOG" id="ENOG503316B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102153_1_0_7"/>
    <dbReference type="OMA" id="HTIIAMV"/>
    <dbReference type="OrthoDB" id="1628716at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="151" mass="16857" checksum="D0ED6A04C451E70B" modified="2005-11-22" version="1">MIVRKRSAGDIVEAKCTRCRAVLNHTIVAMVGERIVRVQCNTCGGQHNYHQPQEEKKPVERSSSQRTASPRTPSAGRPRREPVPKGPSEWELSMERVDPDTATPYAMDRPFRTGEVVSHPVFGIGIVVTVTKPNKVEILFRDGVKLLRCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PQ4</accession>
    <name>Q39PQ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RepA protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_A3565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514711.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3565"/>
    <dbReference type="DNASU" id="3738016"/>
    <dbReference type="EnsemblBacteria" id="ABB33770">
        <property type="protein sequence ID" value="ABB33770"/>
        <property type="gene ID" value="Gmet_A3565"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3565"/>
    <dbReference type="eggNOG" id="ENOG502ZB3T">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051492_0_0_7"/>
    <dbReference type="OMA" id="RRTEIPW"/>
    <dbReference type="OrthoDB" id="1074108at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006881">
        <property type="entry name" value="RepA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04796">
        <property type="entry name" value="RepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="366" mass="41866" checksum="A6A7B25C975BCA93" modified="2005-11-22" version="1">MLFTEMEIEIPKAVFEELQLYIEYLQEKTGKTIDPMAAIGNILQTYFENNGLWGVSEEDFKEKAKIAVKKLLTKKAKKDKPLLTKKVEKLLTQAVEIEQVPAKTAGQIAYQAKALVQVTFPHRDPKTPYYRCDSGKYSLIITADPDHGIPYGTYPRLITCWLVTEIVRTNSRRIVLGKCFSDFLRSIGVGLDSRTRKQVEQQIKRLFSADIKLKYNSKESWQFQRCNVATKAAMWWDTKNPDQFTLDESFVVVGEDFYAMALNAPFPIDLRALAALKQSPMALDIYMWLTLRMCHLAAPYPLSWPQLKSQFGPETSDLDNFRTKFKDALKKVRVVYPHAKLSVNAKELTLFPSPTHVQKAVKRVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q22</accession>
    <name>Q39Q22_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514668.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3440"/>
    <dbReference type="EnsemblBacteria" id="ABB33652">
        <property type="protein sequence ID" value="ABB33652"/>
        <property type="gene ID" value="Gmet_3440"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3440"/>
    <dbReference type="HOGENOM" id="CLU_2861366_0_0_7"/>
    <dbReference type="OMA" id="RTEHKDE"/>
    <dbReference type="OrthoDB" id="2073285at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="65" mass="7532" checksum="5BA49D6CFD2B85B3" modified="2005-11-22" version="1">MKEKDRVAVCERTERKEERVKVRNLKSGEIGYTSFCTEAGETIQVTLENGQFDSWVYADCEELPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q27</accession>
    <name>Q39Q27_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rluD</name>
        <name evidence="5" type="ordered locus">Gmet_3435</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Responsible for synthesis of pseudouridine from uracil.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a uridine in RNA = a pseudouridine in RNA</text>
            <dbReference type="Rhea" id="RHEA:48348"/>
            <dbReference type="Rhea" id="RHEA-COMP:12068"/>
            <dbReference type="Rhea" id="RHEA-COMP:12069"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RluA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514663.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3435"/>
    <dbReference type="EnsemblBacteria" id="ABB33647">
        <property type="protein sequence ID" value="ABB33647"/>
        <property type="gene ID" value="Gmet_3435"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3435"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_4_4_7"/>
    <dbReference type="OMA" id="AHPSPGW"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006225">
        <property type="entry name" value="PsdUridine_synth_RluC/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluC/D_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00005">
        <property type="entry name" value="rluA_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="16"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR606225-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="319" mass="34643" checksum="09401C61B8FD3219" modified="2005-11-22" version="1">MDTTYEFIAPGEGEAGRLDQFVARSVEGMTRSTVQRLIDEGRVTVDGKVEKPSLKLRGGERIVVAVPPPAPAVPEAEEIPLVILHEDSDLVVVNKSAGMVVHPGAGTPGGTLVNALLAHCTDLSGIGGEIRPGIVHRIDKDTTGVLVVAKNDRSHEGLARQFREHTIKRIYLALVFGSPKTDTGRIEGAIGRHPTDRLRMSGKAKHGKHAVTHWKVLARYPGMTLLRLRLETGRTHQIRVHLAESGHPLVGDEVYGGAGRANDLRDPVLKKLVRELGRQALHAKTLGFIHPASGSYVEFDTELPDDMARIITYLEQQGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q85</accession>
    <name>Q39Q85_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ADP-ribosylglycohydrolase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3377</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512603.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3377"/>
    <dbReference type="EnsemblBacteria" id="ABB33589">
        <property type="protein sequence ID" value="ABB33589"/>
        <property type="gene ID" value="Gmet_3377"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3377"/>
    <dbReference type="eggNOG" id="COG1397">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046767_0_0_7"/>
    <dbReference type="OMA" id="GLHWLYD"/>
    <dbReference type="OrthoDB" id="1661477at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005502">
        <property type="entry name" value="Ribosyl_crysJ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036705">
        <property type="entry name" value="Ribosyl_crysJ1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03747">
        <property type="entry name" value="ADP_ribosyl_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101478">
        <property type="entry name" value="SSF101478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="338" mass="37021" checksum="C1D7FB3D7050B499" modified="2005-11-22" version="1">MEQRDREGAAKHRETKGVPTVADRFRGAVWGQFVGDAACLGSHWIYELAELERRFQGGVVGFETPADGHYHTGKHSGELTHYGDGALVMLRSVAERGHFDPQDFGRRFVELFGSDSYRGYLDHATRDTLTHWRAFTETHPGDPYNFQDGADDDQPATATRLVPVVIAHWRDASLLRVVETATRVCQNNDGAVDYLKCHALILRELFNGTDLHEAFHRAATEMERGSGFGPEVADGIRKACASLTLSVRDATLAFGQSCPLSSSFPAAVHCALRHSVDFAAAVLDTANAGGDSAGRAALIGSWLGAFHGIAGISAAWRHRLAARYEIERHLEELVQKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QC6</accession>
    <name>Q39QC6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yccM-1</name>
        <name evidence="6" type="ordered locus">Gmet_3335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33548.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512559.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3335"/>
    <dbReference type="EnsemblBacteria" id="ABB33548">
        <property type="protein sequence ID" value="ABB33548"/>
        <property type="gene ID" value="Gmet_3335"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3335"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033147_0_0_7"/>
    <dbReference type="OMA" id="NFWCRYL"/>
    <dbReference type="OrthoDB" id="1230380at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="251"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33548.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="326" mass="36259" checksum="C18C622CCF500C47" modified="2012-10-31" version="2">MSKRYVQPLRIAIQWGFLLFMVYLGVRLFLFVSHFRTGGAAPFVPRADGVEGFLPIAGLLGVKDWVESGVINPIHPASVVIFVTVVAVSLLLKRSFCSWICPVGTLSELFWKRGFVLFKRNIRPPRWLDVALRGIKYLLLLFFLYSILWAMTPEAATAFIHSDYNAVADVRLLDFFLHLSGIPLAVIAVLLVLSLPVRNPFCRYLCPYGALLGLVSVLSPVKVTREKKTCVSCGVCTQVCPSYIPVMSKERVMSEECVGCWRCVSHCRAMGALEMKLAGRKVAVNAILFAALVVLIVAGGSLVGRATENWKSRIPYAEYMRLLGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QD8</accession>
    <name>Q39QD8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyl viologen-reducing hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mvhP</name>
        <name evidence="2" type="ordered locus">Gmet_3323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3323"/>
    <dbReference type="EnsemblBacteria" id="ABB33536">
        <property type="protein sequence ID" value="ABB33536"/>
        <property type="gene ID" value="Gmet_3323"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3323"/>
    <dbReference type="eggNOG" id="COG0680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099037_2_1_7"/>
    <dbReference type="OMA" id="REFMTGA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="154" mass="16274" checksum="81C8CEE7E9ABC70E" modified="2005-11-22" version="1">MVCVGNDLVADDAAGFEVYRKLAGSSLPPGVTLHYAAVGGIDLLDYLTGDESAMIVVDAVQFGAPTGTIHNLGWNELPDFGAGAISAHFIGLKETIDIGRCLYPELIPSTVLLVGIEGRRFDQTRDAMSPEVAAAIEPATASIREHLHTLRQGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QE2</accession>
    <name>Q39QE2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Methyl viologen-reducing hydrogenase, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">mvhS</name>
        <name evidence="5" type="ordered locus">Gmet_3319</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512543.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3319"/>
    <dbReference type="EnsemblBacteria" id="ABB33532">
        <property type="protein sequence ID" value="ABB33532"/>
        <property type="gene ID" value="Gmet_3319"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3319"/>
    <dbReference type="eggNOG" id="COG1941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053270_0_0_7"/>
    <dbReference type="OMA" id="VKIATTW"/>
    <dbReference type="OrthoDB" id="986649at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="4">
        <location>
            <begin position="14"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="316" mass="34837" checksum="4DD8205EB9709B27" modified="2005-11-22" version="1">MSTVPINLEWLSDCSGCHVAIVDLHEKILAVLESVTIQRCPVLTDVKDYPKAKLGLVSGAIRTEHDRHAAIEMRKSCDLIIAWGSCAVYGGIAGAGNVHSRQEIIDAVYIGNKTTATHAPPTKEVSALEPSVSPLDSVIDVDLYLPGCAPHPAFVFDALLALLEGRSPRTATGESVCARCRRKMEKTEVDRIRKNSEGVPDPDRCFLSQGYLCMGSVTLDRCMSPCPLNGIPCSGCAGATMQVLAEPNRDIRTEIAERMSRLTEIPREAIVREIERTSKTHYSYTMATPMIGEKPTFLIKKWTDEERDDYEQDHNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QI8</accession>
    <name>Q39QI8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512710.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3273"/>
    <dbReference type="EnsemblBacteria" id="ABB33486">
        <property type="protein sequence ID" value="ABB33486"/>
        <property type="gene ID" value="Gmet_3273"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3273"/>
    <dbReference type="eggNOG" id="ENOG502ZD28">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2219349_0_0_7"/>
    <dbReference type="OMA" id="FIAMRSA"/>
    <dbReference type="OrthoDB" id="2020788at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="106" mass="11004" checksum="0EAA267B5C0771AA" modified="2005-11-22" version="1">MKLDVKAALLSAFVLPGLGQVVRGERVKGGILIALANIFLLGAFFLVLKGMGPVLLEAQLAGSVDPNAVTRKLAAGAPAARILLACFAALWCFAVVDAFVGRRKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QT7</accession>
    <name>Q39QT7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3174</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513890.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3174"/>
    <dbReference type="EnsemblBacteria" id="ABB33387">
        <property type="protein sequence ID" value="ABB33387"/>
        <property type="gene ID" value="Gmet_3174"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3174"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_543785_0_0_7"/>
    <dbReference type="OMA" id="DTCEHCH"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3820.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005126">
        <property type="entry name" value="NapC/NirT_cyt_c_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038266">
        <property type="entry name" value="NapC/NirT_cytc_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03264">
        <property type="entry name" value="Cytochrom_NNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_NNT" evidence="4">
        <location>
            <begin position="98"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="504" mass="57156" checksum="C3272A087000AA12" modified="2005-11-22" version="1">MALRKTAGYLWNPISLIGLLLAFVGTGLIIAFLAMEMITGVEHPYIGLLTYFAFPGMLIFGLILVPVGAWMVRNRRRKEEEDIPPYPRMDFNDPHKRRLFIFFVLASVIFVLIVSVASILGFEFTESTTFCGELCHTVMTPEHTAWKNSPHARVKCVECHVGPGAEWYVKAKISGLRQVWAVATHSYPTPIETPIENLRPARDTCEHCHWPEKFYSGRQKIFYHYAPNKENTPREINMLINIGGAPKSPHAKGIHWHIGTEVYYISRDKKRLDIPYIAVKQKDGSFVEYMSTETPLTRDEIAKAKKRLMDCTDCHNRPTHIYKSPGQEMDEHIVSGLIDPALPYIKKIGVELLEKPYKTQQEAFTAIAAKLPEYYATNYPEVSKTKAAAINQAVTQVKDIYSRNFFPEMKVSWNTYPNHIGHFYTPGCFRCHDGKHKSIDGKKTISKDCNMCHTMISQTQENIPAGKQVKDFVHPVDIGDEIHKTNCSDCHMSGGEDVPGGGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QY4</accession>
    <name>Q39QY4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redox-active protein, C_GCAxxG_C_C family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514301.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3126"/>
    <dbReference type="EnsemblBacteria" id="ABB33340">
        <property type="protein sequence ID" value="ABB33340"/>
        <property type="gene ID" value="Gmet_3126"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3126"/>
    <dbReference type="eggNOG" id="ENOG5030CC5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091283_0_0_7"/>
    <dbReference type="OMA" id="GKMHCAE"/>
    <dbReference type="OrthoDB" id="2083729at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01909">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="142" mass="15101" checksum="6E8D8258CC137384" modified="2005-11-22" version="1">MFWQKKQVTPADESVAEKVGIEAEGFYRSGKMHCAEAVLMAARNQFFPSVPEDVVGAASGFGGGSGVGCVCGAVAGGTMAFGFVLKDDKRKLKRVTKELHEWFKQEYGASCCRIATKNAKDRGGCAVLTGEVAKKMAELLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R07</accession>
    <name>Q39R07_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar hook protein FlgE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">flgE</name>
        <name evidence="9" type="ordered locus">Gmet_3103</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514278.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3103"/>
    <dbReference type="EnsemblBacteria" id="ABB33317">
        <property type="protein sequence ID" value="ABB33317"/>
        <property type="gene ID" value="Gmet_3103"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3103"/>
    <dbReference type="eggNOG" id="COG1749">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_2_4_7"/>
    <dbReference type="OMA" id="GLQNHQT"/>
    <dbReference type="OrthoDB" id="704242at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.98.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011491">
        <property type="entry name" value="Falgellar_hook_FlgE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037058">
        <property type="entry name" value="Falgellar_hook_FlgE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07559">
        <property type="entry name" value="FlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="9" id="KW-0966">Cell projection</keyword>
    <keyword evidence="9" id="KW-0969">Cilium</keyword>
    <keyword evidence="9" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="6">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="FlaE" evidence="8">
        <location>
            <begin position="183"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="7">
        <location>
            <begin position="340"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="419" mass="43979" checksum="9511A14873819C08" modified="2005-11-22" version="1">MSVTSALYTGISGLNANGEAMSVIGNNISNVNTIGFKQGRMLFSDVLSSTISGGSQIGRGVQIQTVENQFTQGSFESTESGTDLAVQGDSFFVVQNDNGRYYTRAGAFTFDKDKTLVNPEGYQVQGYGIIPSSGLADGVMKPIDLTTFATTPPKQTSAVDMVLNLDSTQSTPALPWNPANPVATSNFSTSLSVYDSQGNAHTATVYFRKTAANAWDWHAILPDAQAGTPGSSTTPLDGTLTFDATGALTGQTPLASAAQNITFTGGVTAPQPILFGMGVGATTQYASPSIVSSQTQDGYYQGTLTKVTIDDKGYVNGVYSNGELKKLYQVALAKFASTTGLSKAGGTLFEETLDSGQPLFSNASTPGVGKVLANSLEQSNVDMAAQFVKMITTQRGYSANSKTITTADEMLQEVLNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R12</accession>
    <name>Q39R12_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flagellar protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">fliO</name>
        <name evidence="6" type="ordered locus">Gmet_3098</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FliO/MopB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366143.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3098"/>
    <dbReference type="EnsemblBacteria" id="ABB33312">
        <property type="protein sequence ID" value="ABB33312"/>
        <property type="gene ID" value="Gmet_3098"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3098"/>
    <dbReference type="eggNOG" id="COG3190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142794_0_0_7"/>
    <dbReference type="OMA" id="APKKSLM"/>
    <dbReference type="OrthoDB" id="2022958at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022781">
        <property type="entry name" value="Flagellar_biosynth_FliO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04347">
        <property type="entry name" value="FliO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03500">
        <property type="entry name" value="FliO_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="1 5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="158" mass="16874" checksum="3362F30DC75AC50B" modified="2005-11-22" version="1">MSGAATAATLVPAAALAADGQGSPSLFMLTLQMVAALGVVLGLIYLFYHLSNRWLKLGAPMGGGERHIRLVETRHLAPKKSLVLVEVGGEFLLLGSSNDNLTFIKQIDILEEIEVIDDPEKQSTMAALFQGKLDAMAAKIAAIKQGRADSPSRRAEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R27</accession>
    <name>Q39R27_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HAD superfamily hydrolase, ferritin-like domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3083</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514537.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3083"/>
    <dbReference type="EnsemblBacteria" id="ABB33297">
        <property type="protein sequence ID" value="ABB33297"/>
        <property type="gene ID" value="Gmet_3083"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3083"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_762386_0_0_7"/>
    <dbReference type="OrthoDB" id="1563286at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="222"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="363" mass="41599" checksum="1A67EF6E670D7EB2" modified="2005-11-22" version="1">MSGIRALVFDLDGTLYDSEGVGRQIDASAMGHVAAVRGISPEEARLLIRETREKIAVRTGRTASLSHVCLELGIDLRELHRRFEAEIEPEPFLTRDERVVELLERLGERFDLHIYTNNNRLLSSRIMTALGVDGCFRRIFTIEDSWRPKPDRQVLEEIFREIGQEPSHCLFVGDRYDIDLRLPRELGCRVFHSRTVDELLTIETTLPSGAPMNDQTKETLDAIMRAIEIEKETFDFYTRAERKTFNPEGKRIFRWLAKTEEQHYLKLNELYQSLHEGGRWVFYGGSTITLDPAGSGEKQVGFDTDDLQALEIAMEIEKKGIAYFDDLMAKTADADGKGMLKALRDEETEHLRVITEKYNAIKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RB0</accession>
    <name>Q39RB0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response receiver-modulated cyclic diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514490.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2999"/>
    <dbReference type="EnsemblBacteria" id="ABB33214">
        <property type="protein sequence ID" value="ABB33214"/>
        <property type="gene ID" value="Gmet_2999"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2999"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_10_7"/>
    <dbReference type="OMA" id="LMKAGPL"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="3">
        <location>
            <begin position="152"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="361" mass="40383" checksum="252446811DAC51A3" modified="2005-11-22" version="1">MPALEQPPNIMIVDDTPANLRLLETMLQEKNYRVLLFPRADIALKAAKKNPPDLVLLDITMPGMDGFQFCASLKADSRLCSTPVIFLSGLNEPADKVKAFSLGGVDYITKPFQLEEVHARVETHLNLRRLQMEVESHNRNLESQVEAYAKEIIASQMATIFALAKLAESRDDNTGKHVERVQIYCRLLAQRLAEKGPYRGEVTPEFINNITFASPLHDIGKVAIVDRVLLKPDKLTAEEFKIMQTHTVIGAQTLATALAKYPQNEFLRTGIAIAQSHHEWWDGTGYPDGIKGREIPLHARITAVADVYDALRSNRCYRLSLPHEEVRAMILEGSGTQFDPDVVAAFIESEDEFFAISCELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RE5</accession>
    <name>Q39RE5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33179">
        <property type="protein sequence ID" value="ABB33179"/>
        <property type="gene ID" value="Gmet_2963"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2963"/>
    <dbReference type="eggNOG" id="ENOG5032X47">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_579724_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="471" mass="54357" checksum="64EAF49341CBEB64" modified="2005-11-22" version="1">MAMIPNLDWYLSISTQQQLSPRCPYATVYHCPRYYQSLSLLGEAGSTGIAPAEDSRLKQQWEQTEVWPVTAEQATSISGPGNEVKHFMRFCPEVSYDRFGLFAAELHRFADEIDVDCTHKTLRNEGATPEDWRWNWSLVESMHYTQCPLYSLLRVGKGKDGPKPIFPDIGMPDSITSHLVSITECDDYTAQDVENLIVEMYEHPEIKTYEIYCRQENPHLQRALDDYRITGDTVKMHYYKDPDYELSFVKINKNAATSDWEKHLIATSPMYFKREITLSDRQRERMDRERSQTVWDRAQRHPVYVILMILAAIASLIGLVALFRGTEDNNKINSQTAPQLHEVAKTPVMRNLSSSSVASPPPVQEHTTSKNVRFEESLARMKVKLRSGMSYEQLVELLDEARVAKTMSGDIAPVQIRQFSCYEELENLWSQRTPNALLQRGVVSSWEEAKREYSFTEEPIINKKFAECYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RG7</accession>
    <name>Q39RG7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis sensory transducer, class 40H, putative dimer with helix-swapped heme-binding site-containing PAS domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mcp40H-2</name>
        <name evidence="6" type="ordered locus">Gmet_2939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512875.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2939"/>
    <dbReference type="EnsemblBacteria" id="ABB33157">
        <property type="protein sequence ID" value="ABB33157"/>
        <property type="gene ID" value="Gmet_2939"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2939"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_32_7"/>
    <dbReference type="OMA" id="ERCKQCH"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="194"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="253"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="696" mass="75184" checksum="32FD0578D254465B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RI4</accession>
    <name>Q39RI4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2922</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512858.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2922"/>
    <dbReference type="ESTHER" id="geomg-q39ri4">
        <property type="family name" value="ABHD13-BEM46"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33140">
        <property type="protein sequence ID" value="ABB33140"/>
        <property type="gene ID" value="Gmet_2922"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2922"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029375_2_1_7"/>
    <dbReference type="OMA" id="PNGGHND"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydrolase_4" evidence="1">
        <location>
            <begin position="64"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="285" mass="31068" checksum="6F58D03BCC045043" modified="2005-11-22" version="1">MRISSVVALMTLLLLCTGCSSLIFYPQRHLVDNQLLVRFPAEDISFRASDGVRLHGWLLRPSGQPRGSILVLHGNAENISTHVNSILWLVKEGFAVFIIDYRGYGLSEGTPTIDGVHRDAEAALATLLTLPGVDPQRVAVLGQSLGGAIAIHLVATTPHKKAVRLLVVDSPFADYRLIAREKLGGFFLTWPFQYPLSLLFNDDYSPLRFVGEVAPVPLIIINDELDPIVPSRHGRLLREAAGPSADLWTTSGLGHVGSFADPALRRALVERLDGAFAPGADTQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RM1</accession>
    <name>Q39RM1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucose--lipopolysaccharide core heptose I 4-beta-glucosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512821.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2885"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33103">
        <property type="protein sequence ID" value="ABB33103"/>
        <property type="gene ID" value="Gmet_2885"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2885"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065962_1_0_7"/>
    <dbReference type="OrthoDB" id="1379602at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="287" mass="33658" checksum="49F5315339BD417D" modified="2005-11-22" version="1">MTTISAVLIVRNEELNICSCLQTLCWCDEIVVVDMESEDRTVALARQFTNKIYSHEKVMAFDIARDFAVKQATCDWIFMIDADELVTNTLKTAVVSVVDENDYDVVYFPRINFIFGKWIQNAGWWPDYQARLFRNGAISFSGRVHNFIEIAHGSRIKYLDLAEDNAIIHFNYEHSHQFISKLNHYTSIEARDLKAAGHKFSKKVFFVEVLREFYNRYFKTKGYREGMHGLFLSLLMMFYRISVFIKLWECHEHEKRSVSEMYNAMKQEITAQHLTGSIKDENPPVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RR1</accession>
    <name>Q39RR1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome-binding ATPase YchF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">ychF</name>
        <name evidence="7" type="ordered locus">Gmet_2845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514571.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2845"/>
    <dbReference type="EnsemblBacteria" id="ABB33063">
        <property type="protein sequence ID" value="ABB33063"/>
        <property type="gene ID" value="Gmet_2845"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2845"/>
    <dbReference type="eggNOG" id="COG0012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018395_0_1_7"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="603226at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="SSF81271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00092">
        <property type="entry name" value="TIGR00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="3"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="279"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="364" mass="39794" checksum="7DDE9A4A41A1BE1C" modified="2005-11-22" version="1">MGFNCGIVGLPNVGKSTIFNALTSAGAESANYPFCTIDPNVGIVQVPDERLERLAEIVNPERILPTTIEFVDIAGLVKGASQGEGLGNQFLGHIRSVDAIVHVVRCFDDENVVHVSGSVDPIRDIEVIQTELALADLDSVEKKFQRVEKQAKGGDRKLKDESEFYARVKGALEKGTPGRHVEVGDDERLWMRDLHLLTDKPVLYVANVAEDDLEGAHPFVAKVRDLAESEGARVVVICGRIESEIAELDGDEKKVFLAEMGLAESGLDRLIRMGYDLLGLITYFTAGKKEVRAWTIPAGTKAPQAAGVIHSDFEKGFIRAEVIAYRDFVAAGGETGAKEKGLMRLEGKEYVVQDGDVMHFRFNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RU1</accession>
    <name>Q39RU1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycosyltransferase HpnI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hpnI</name>
        <name evidence="5" type="ordered locus">Gmet_2815</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513990.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2815"/>
    <dbReference type="CAZy" id="GT21">
        <property type="family name" value="Glycosyltransferase Family 21"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33033">
        <property type="protein sequence ID" value="ABB33033"/>
        <property type="gene ID" value="Gmet_2815"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2815"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030898_2_0_7"/>
    <dbReference type="OMA" id="NPKLNNC"/>
    <dbReference type="OrthoDB" id="724641at2"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017835">
        <property type="entry name" value="Hopen-assoc_HpnI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="PTHR12726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03472">
        <property type="entry name" value="HpnI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="391" mass="42567" checksum="9BEBB054A249DCDC" modified="2005-11-22" version="1">MLTTVLPFLCILPPLAYGVIALGCARSYFGRRRPAPGHTPPISILKPVKGMDAGSFDNFASFCRQEYPAPWQIVFAVADPADPVIPVIGRLMGEFPAIDMELVVDATIHGPNHKVSNLINACPKAKHDLLIVCDSDIRVSPDYLREVAAPFADQQVGLVTSLYRSPGVAGAATAVEAMGFTVEMIPNVMVAMKLEGLSFALGASMAVRREALEAIGGFAALADYLADDYQLGNKVHKVGWRLELSDCFVESVMHREDLATVLSRQLRWSRTMRVSRPGGYLGSGITQSFPMACLALALSGFSGAGWGAVLLLYLVRAAVAMAFSRCYVKDGIFPRWLWLLPLRDFLAFATWALSFAGNRVRWRGNLFRLLPGGKIVELPKTFETRGNGATE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RW6</accession>
    <name>Q39RW6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511672.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2790"/>
    <dbReference type="EnsemblBacteria" id="ABB33008">
        <property type="protein sequence ID" value="ABB33008"/>
        <property type="gene ID" value="Gmet_2790"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2790"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="LQISAFP"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="247"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="150"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="463" mass="52079" checksum="CCFE098F18EA5E8A" modified="2005-11-22" version="1">MTRILIVDDNEQNLYMLEVLLSAHGFQALSATNGAEALALAQASPPDLIISDILMPVMDGYAFCRECKKTAQLNDVPFIFYTATFTEAEDEKLALSLGADRFLLKPQEPDEMMRIVRELLAVPRPGTGREPSEKGQEQAEHLQKYGEALFRKLEKRMADLKQANRALEHEIEERKKAELELQQVNRTLEERVAERTALLAAANGQLQEEVQRSRQAQNEIALLNDVLVRRTESLEGLNRELEAFSSAVTHDLQAPLRSIIGYAGIVREECENAVDGSVLEYIGRIERSVNRMNELIEALRDLSQASSAALHPDTVNLSTIVREIISALQEADSERRVTFVIADGVTAEADRPLITSVIDNLLNNAWKYSRRNETARIEFGALEKDQEHVYFVRDNGAGFDMKYASKLFTPFQRLHRQDEFEGTGVGLATVQRIIHRHGGRIWAEAKVAEGATFYFTLSRAMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S05</accession>
    <name>Q39S05_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Corrinoid-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2751"/>
    <dbReference type="EnsemblBacteria" id="ABB32969">
        <property type="protein sequence ID" value="ABB32969"/>
        <property type="gene ID" value="Gmet_2751"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2751"/>
    <dbReference type="eggNOG" id="COG5012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082102_2_0_7"/>
    <dbReference type="OMA" id="MTSTMDN"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="1">
        <location>
            <begin position="103"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="236" mass="24916" checksum="6790E568DF0BDC84" modified="2005-11-22" version="1">MAAPMPDMTGEGTTLQKLVAEVLRRINDADRDGASRLVDQWAAVHGYGDAIAEILEPVLRTVGDRWEREAISLAQGFVAGKVAEDILNKALAAAPKGVFGEVKGPVVIGNIEDDYHSLGRGMVGTFLRAAGWAVIDMGNDVSPAEFVDRAVETGARVIGVSAMMFVTARGIRGVRDELDRRGLSGRIMLAVGGAVFKVRPELVAEVGGDGTAGSAMDAPVLFKSLWERSLDAGGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S68</accession>
    <name>Q39S68_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMMECR1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511773.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2688"/>
    <dbReference type="EnsemblBacteria" id="ABB32906">
        <property type="protein sequence ID" value="ABB32906"/>
        <property type="gene ID" value="Gmet_2688"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2688"/>
    <dbReference type="eggNOG" id="COG2078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095686_1_1_7"/>
    <dbReference type="OMA" id="RGCIGFP"/>
    <dbReference type="OrthoDB" id="1812209at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027623">
        <property type="entry name" value="AmmeMemoSam_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="PTHR13016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="SSF143447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04335">
        <property type="entry name" value="AmmeMemoSam_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00296">
        <property type="entry name" value="TIGR00296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="1">
        <location>
            <begin position="8"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="180" mass="19967" checksum="BBB0B2BA34A4CDF1" modified="2005-11-22" version="1">MSQNLTLTEKKKLLSLAREAIIDYIREGNLPHRLETAPSLQGQQGCFVTIKMNGTLRGCIGSFVSDKPLYRLVQDMAISAATRDPRFYPMKPADLEGFSIEISVLGPLEKISSPEGIKVGTHGIYIEKNSCRGVLLPQVAVEYNWDKDTFLSQTCLKAGLKPDDWKEGADLYVFSAQIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SH5</accession>
    <name>Q39SH5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Excinuclease ABC family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Gmet_2580</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366071.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2580"/>
    <dbReference type="EnsemblBacteria" id="ABB32799">
        <property type="protein sequence ID" value="ABB32799"/>
        <property type="gene ID" value="Gmet_2580"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2580"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_3_0_7"/>
    <dbReference type="OMA" id="SKHGWCP"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="1223"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB32799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1892" mass="205989" checksum="BF6BB237AA6A33C7" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SI8</accession>
    <name>Q39SI8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acyl-(Acyl carrier protein)--UDP-N-acetylglucosamine/UDP-2-N-acetylglucose-2, 3-diamine 3-O/N-acyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lpxA-2</name>
        <name evidence="7" type="ordered locus">Gmet_2567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513467.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2567"/>
    <dbReference type="EnsemblBacteria" id="ABB32786">
        <property type="protein sequence ID" value="ABB32786"/>
        <property type="gene ID" value="Gmet_2567"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2567"/>
    <dbReference type="eggNOG" id="COG1043">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061249_0_0_7"/>
    <dbReference type="OMA" id="LCGIHQF"/>
    <dbReference type="OrthoDB" id="971098at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008780">
        <property type="term" value="F:acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03351">
        <property type="entry name" value="LbH_UDP-GlcNAc_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029098">
        <property type="entry name" value="Acetyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037157">
        <property type="entry name" value="Acetyltransf_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010137">
        <property type="entry name" value="Lipid_A_LpxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43480">
        <property type="entry name" value="PTHR43480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13720">
        <property type="entry name" value="Acetyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000456">
        <property type="entry name" value="UDP-GlcNAc_acltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01852">
        <property type="entry name" value="lipid_A_lpxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Acetyltransf_11" evidence="6">
        <location>
            <begin position="176"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="269" mass="28999" checksum="F226416871D73403" modified="2005-11-22" version="1">MTTSIHPSAQISPSATIADGVEIGANVIVGDHSSIGAGTKVMANAVIGPWTKIGENNTIHYGAIVGHDPQDFGYKGEESWTIIGNGNIIREGATIHRGNRPGTNTVVGDNNFFMVNSHVGHNCVLGNNIILVNGVLLAGHVVVEDRAIVSGNCVVHQFCRIGKFAMMRGLSRTSRDVPPFCIMDDTHTVKALNLVGLRRNGFDQARIRAIKNAFKLLFLSGLNMQNALAEAERTLTITDDVRYLLDFIKSAKRGVCFGHGVIVDVEEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SM0</accession>
    <name>Q39SM0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin, RelE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2533</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366069.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2533"/>
    <dbReference type="EnsemblBacteria" id="ABB32754">
        <property type="protein sequence ID" value="ABB32754"/>
        <property type="gene ID" value="Gmet_2533"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2533"/>
    <dbReference type="eggNOG" id="COG3657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_152445_0_1_7"/>
    <dbReference type="OMA" id="EYMATAK"/>
    <dbReference type="OrthoDB" id="1733128at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014056">
        <property type="entry name" value="Addiction_killer_pred"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41791">
        <property type="entry name" value="PTHR41791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028744">
        <property type="entry name" value="Addict_mod_HI1419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02683">
        <property type="entry name" value="upstrm_HI1419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="96" mass="10725" checksum="B4A97F5F342C4796" modified="2005-11-22" version="1">MIEIRKTEHFANWLDNLRDIQAKARVLVRIERLASGNAGDVKPVGEGVSEMRINYGPGYRVYFIQRGSELIILLAGGDKSSQSRDIKAAVRLAQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SQ1</accession>
    <name>Q39SQ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2500"/>
    <dbReference type="EnsemblBacteria" id="ABB32723">
        <property type="protein sequence ID" value="ABB32723"/>
        <property type="gene ID" value="Gmet_2500"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2500"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_153045_4_1_7"/>
    <dbReference type="OMA" id="AFDTVCW"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018841">
        <property type="entry name" value="DUF2442"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036782">
        <property type="entry name" value="NE0471-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10387">
        <property type="entry name" value="DUF2442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143880">
        <property type="entry name" value="SSF143880"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="85" mass="9755" checksum="0D8BCC7B00C1D183" modified="2005-11-22" version="1">MESVIKVVPQDDFHLLITFNTGETRLFDARPYLEKGVFNRLKNLELFKQAFVAFDTVCWPDNLDIAPETLYDRSQSLPCSEVSNG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SQ6</accession>
    <name>TRPD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anthranilate phosphoribosyltransferase</fullName>
            <ecNumber evidence="1">2.4.2.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trpD</name>
        <name type="ordered locus">Gmet_2495</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + N-(5-phospho-beta-D-ribosyl)anthranilate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate</text>
            <dbReference type="Rhea" id="RHEA:11768"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anthranilate phosphoribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.18" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514651.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SQ6"/>
    <dbReference type="SMR" id="Q39SQ6"/>
    <dbReference type="STRING" id="269799.Gmet_2495"/>
    <dbReference type="EnsemblBacteria" id="ABB32718">
        <property type="protein sequence ID" value="ABB32718"/>
        <property type="gene ID" value="Gmet_2495"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2495"/>
    <dbReference type="eggNOG" id="COG0547">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034315_2_1_7"/>
    <dbReference type="OMA" id="GPMTNPA"/>
    <dbReference type="OrthoDB" id="1238435at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00041"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004048">
        <property type="term" value="F:anthranilate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00211">
        <property type="entry name" value="TrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005940">
        <property type="entry name" value="Anthranilate_Pribosyl_Tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000312">
        <property type="entry name" value="Glycosyl_Trfase_fam3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017459">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036320">
        <property type="entry name" value="Glycosyl_Trfase_fam3_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035902">
        <property type="entry name" value="Nuc_phospho_transferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43285">
        <property type="entry name" value="PTHR43285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02885">
        <property type="entry name" value="Glycos_trans_3N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00591">
        <property type="entry name" value="Glycos_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47648">
        <property type="entry name" value="SSF47648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52418">
        <property type="entry name" value="SSF52418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01245">
        <property type="entry name" value="trpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="chain" id="PRO_0000227158" description="Anthranilate phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="104"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="122"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>anthranilate</name>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00211"/>
        </source>
    </evidence>
    <sequence length="350" mass="36897" checksum="FEFC141F585AA4CE" modified="2005-11-22" version="1">MIKKAIAKVVERIDLTEAEMIEVMDQIMSGEATPAQIASFITALRMKGETVEEITGAARVMRDRATPIRVGKGVLDIDRDDINIDQETILDVVGTGGDGTNTFNISTTVSFVVASCGVKVAKHGNRAVSSACGSADVLESLGVSLDVTPETVENAIARIGIGFLFAPALHGAMKHAIGPRKEIGIRTIFNILGPLTNPAGADCQVLGVYREDLVEPLAHVLHKLGCKRGFVVFGMDGMDEITLTRETRVAEVTREGVTVRTITPEEFGFASCPPGDLRGGDAAGNARIVRSILDGATGPRRDVVLLNAAYALVAAGKATDPAEGIRLAAEAIDSGRALAKLEELIALTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T58</accession>
    <name>Q39T58_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose--lipopolysaccharide heptosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32566.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513279.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2341"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="DNASU" id="3738801"/>
    <dbReference type="EnsemblBacteria" id="ABB32566">
        <property type="protein sequence ID" value="ABB32566"/>
        <property type="gene ID" value="Gmet_2341"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2341"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_3_3_7"/>
    <dbReference type="OMA" id="SICRISD"/>
    <dbReference type="OrthoDB" id="1326265at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32566.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="338" mass="37090" checksum="2446977A45220F4E" modified="2012-10-31" version="2">MLLSTPLALSIKERFPDATIDYLVLKGTEGVLAKNPLIRSVHTIDPQKSVVPLLLSLWKKYDYAIGSNVSDRTTLFCVAAGRRSYGFSYFRGKEWWKKLLLSSCRLYDDRMHIVPLVLTRLEPLAIPPRPRVVAGGDAEDEAYAARLFGDAGYVVLHPYSRKEYKCWTVDGWRRLAGLILDAGLKPLFTVSPNADDAKMLADILAVAPEGTGSIGDVLSFPRLAAVIRRGRGYVGVDTVVTHMAAALDVPTVALYGPTLVHHWGPWPNDFPGSAPYGPRGTIQRQGSIVVIQKEWECVPCNREECSRTDGGPIACMDAITPEEVMTELAGLLETGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TE8</accession>
    <name>Q39TE8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366003.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2249"/>
    <dbReference type="EnsemblBacteria" id="ABB32476">
        <property type="protein sequence ID" value="ABB32476"/>
        <property type="gene ID" value="Gmet_2249"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2249"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_7"/>
    <dbReference type="OMA" id="NISSMWG"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="27886" checksum="ECB10193078B2638" modified="2005-11-22" version="1">MGKLDGKVAIVTGGARGMGQTTAEVFVQEGASVVIVDVLDVEGEALAKRLGRNTMYQHLDVTDEQGWEQLVEGIIDRYGCIDILVNNAAVFFSSPIDETRSEAFRRILDINLIGPYLGMKAVIPTMKKNRRGSIINVSSVNGLRGSSGSGAYSASKWGVRGLTKCVAMEVGPFGIRVNSLHPGWIVTPMNNPDGKSFEEVNAELKIKFPGIALSRVGQSEEIARASLFLASDDSSYISGAELAVDGAWSCGVYLQDKPMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TF2</accession>
    <name>Q39TF2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365999.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2245"/>
    <dbReference type="EnsemblBacteria" id="ABB32472">
        <property type="protein sequence ID" value="ABB32472"/>
        <property type="gene ID" value="Gmet_2245"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2245"/>
    <dbReference type="eggNOG" id="COG4447">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063224_1_0_7"/>
    <dbReference type="OMA" id="GHDATII"/>
    <dbReference type="OrthoDB" id="1293876at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028203">
        <property type="entry name" value="PSII_CF48-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14870">
        <property type="entry name" value="PSII_BNR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223108" evidence="1">
        <location>
            <begin position="25"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="PSII_BNR" evidence="2">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="PSII_BNR" evidence="2">
        <location>
            <begin position="156"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="352" mass="37947" checksum="3F2F3B6416B7546C" modified="2005-11-22" version="1">MLSKILKTSLCFIFMTCWVTTAQAFKGPLETPASMKLHATTSQLTAVTRNGNRLAAVGARGLVLLSDDNGKKWQQVAVPVSSNLVSVQFPVPDQGWAVGHDGVVLHSGDGGRTWSKQLDGNQVAKIMLKHYEKLAAEGDAAASKILPDIQRILQEGADKPFMDVWFLDEKEGFVAGAFNLIMHTTDAGKTWVPLFERTDNPKNLHIYALKGVGKEVYLAGEMGMLRRWDRASQRFVTIASPYKGTFFGLLAKDTTILAFGLRGNAFRSSDRGNTWRKLNTNTTAGLTGGTFLDDGRAVLVSQDGQVLVIDVGSETFVPAKVSSPMAFSSVAPAGKNGIVAVGSRGVITESLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TS3</accession>
    <name>Q39TS3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Menaquinol oxidoreductase complex, cytochrome c subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pcmF</name>
        <name evidence="6" type="ordered locus">Gmet_2122</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32351.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365920.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2122"/>
    <dbReference type="EnsemblBacteria" id="ABB32351">
        <property type="protein sequence ID" value="ABB32351"/>
        <property type="gene ID" value="Gmet_2122"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2122"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092326_0_0_7"/>
    <dbReference type="OMA" id="RACHVIN"/>
    <dbReference type="OrthoDB" id="1168761at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="173"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32351.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="307" mass="34917" checksum="A3F92DA149BB5FFD" modified="2012-10-31" version="2">MEKAVSRKLTLFCVICGLAVLVLMGATVIRDGEREWKHYQTQYREMLLKMIKKEDNPTFYQRVEEMKPEIRQIVVDEWKTVDRCTTCHLGIEDPLFANAKQPFTTHPNPELLKHHPVDKFGCTMCHGGQGLATTYNGSSHQPIDNWPITLVSKGLMQSRCGYCHKDFEAIKADRLIKGRELYKEMHCAGCHQIDGQGGNVGPDLSNFADKDPSNFSYESIEGPHSKQTWVIEHFRDPKRVSPGTPMRTYAMNDDQIECLASYVLSLTQRGFSRPYSTKVKADFVPHKVDEYVPEPELSDSADDAESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TT0</accession>
    <name>Q39TT0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor protein serine/threonine phosphatase, PP2C family, PAS and PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2115</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513090.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2115"/>
    <dbReference type="EnsemblBacteria" id="ABB32344">
        <property type="protein sequence ID" value="ABB32344"/>
        <property type="gene ID" value="Gmet_2115"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2115"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_524616_0_0_7"/>
    <dbReference type="OMA" id="ANAGHNH"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="104"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="174"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="2">
        <location>
            <begin position="233"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="536" mass="60052" checksum="5AF9165E36B53D45" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TW0</accession>
    <name>Q39TW0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster-binding oxidoreductase, CCG domain pair-containing, putative benzoyl-CoA reductase electron transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bamD</name>
        <name evidence="2" type="ordered locus">Gmet_2085</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514581.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2085"/>
    <dbReference type="DNASU" id="3739536"/>
    <dbReference type="EnsemblBacteria" id="ABB32314">
        <property type="protein sequence ID" value="ABB32314"/>
        <property type="gene ID" value="Gmet_2085"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2085"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023081_2_2_7"/>
    <dbReference type="OMA" id="CYLGRAN"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="59"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="387" mass="43183" checksum="8F8EB74333EFD2AF" modified="2005-11-22" version="1">MGAIVETVTPYKEIIDVIKEKGGDSLKYCYQCGLCDSVCPWNRVRQFSMRKIVRQGTFGLTEIEQEDIWRCSTCGTCPSRCPRGVNQIEAGVAMRRIGAEYDVYPGHVGTIRNVVASLTSEGNSLGGDRTQRGDWAKDLPVKPYAEGMELLYFTGCYLSYDPRMRKVAAATAAILNKAGVDFGILGSKESCCGESIRKTGNEELFKRLAKENIKQFIDNGVTKILVSSPHCYHTFVNEYPEFKVNFEVVFISQYIGQLINEGRLQITGEFAKKVTYHDPCYLGRHNGIYDEPRQVLQQVPGLELLEMADNRESSLCCGGGGGRIWMETPKEERFADLRIRQAVDVGATVLATSCPYCITNFTDSSLDLADHEKVEVKDLAEIILEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TY5</accession>
    <name>Q39TY5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, FUSC domain-containing, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514043.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2060"/>
    <dbReference type="EnsemblBacteria" id="ABB32289">
        <property type="protein sequence ID" value="ABB32289"/>
        <property type="gene ID" value="Gmet_2060"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2060"/>
    <dbReference type="eggNOG" id="COG1289">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013927_1_2_7"/>
    <dbReference type="OMA" id="LNDPWLF"/>
    <dbReference type="OrthoDB" id="1320135at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006726">
        <property type="entry name" value="PHBA_efflux_AaeB/fusaric-R"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04632">
        <property type="entry name" value="FUSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="635" mass="68200" checksum="D18B41044862C952" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U45</accession>
    <name>Q39U45_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512950.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2000"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32229">
        <property type="protein sequence ID" value="ABB32229"/>
        <property type="gene ID" value="Gmet_2000"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2000"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028014_0_1_7"/>
    <dbReference type="OMA" id="WRYRRWE"/>
    <dbReference type="OrthoDB" id="948440at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="403" mass="45623" checksum="00F02FF082D11547" modified="2005-11-22" version="1">MNVLFLSTKSPYPLINGHSLRTYHTLRDAARRHDVTLVTFIQQPEHELKPEHIEHLKSFCKEVHTFPIPVDQSRAKLAFSLGCNLFSDLPFVASKYDSPAMRAKIREIIANNKIDLVHVDLLPLSVYLSEFFHLPKILVNHNVESIRLQRWAESDPSTLKRAFLKLQWQRLCRFEKEMVNRFDRCIAVSELDRDVLVGMGITIPISVVPNGTNTEFFKPIGRPPVENSVLWLGHMDVHTNRDAVLYFWREICPLIRQRQPDATMIFVGTAPPREIAEAAASDPRVRVTGFVDDIRTYVDEARVVVVPIRIGSGTRLKILDAMGMGKAIVSTSVGCEGLAVEHGRNILVADTPEAFADEVMSVLANRDLREALERNARECALTYDWGRLCEEQERTYQAAAGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UA0</accession>
    <name>Q39UA0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_1945</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365890.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1945"/>
    <dbReference type="EnsemblBacteria" id="ABB32174">
        <property type="protein sequence ID" value="ABB32174"/>
        <property type="gene ID" value="Gmet_1945"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1945"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_398886_0_0_7"/>
    <dbReference type="OMA" id="VYEFNEL"/>
    <dbReference type="OrthoDB" id="1827824at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17203">
        <property type="entry name" value="sCache_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="11">
        <location>
            <begin position="193"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="278"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="9">
        <location>
            <begin position="421"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="237"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="690" mass="76888" checksum="04AC76457F793BB1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UC0</accession>
    <name>Q39UC0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32154.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511918.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1925"/>
    <dbReference type="EnsemblBacteria" id="ABB32154">
        <property type="protein sequence ID" value="ABB32154"/>
        <property type="gene ID" value="Gmet_1925"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1925"/>
    <dbReference type="HOGENOM" id="CLU_2824994_0_0_7"/>
    <dbReference type="OMA" id="CTAFVSC"/>
    <dbReference type="OrthoDB" id="2090014at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32154.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="67" mass="7440" checksum="343AF62EEEC67D87" modified="2012-10-31" version="2">MVVLVRCTDDTVTVAQGSKLSKLIKDGLVKSFLRSGVWVEAVNYRQEITRRPSPSSDSRCTAFVSCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UJ6</accession>
    <name>Q39UJ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ParA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511997.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1849"/>
    <dbReference type="DNASU" id="3741526"/>
    <dbReference type="EnsemblBacteria" id="ABB32078">
        <property type="protein sequence ID" value="ABB32078"/>
        <property type="gene ID" value="Gmet_1849"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1849"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_586310_0_0_7"/>
    <dbReference type="OMA" id="HFTIDKM"/>
    <dbReference type="OrthoDB" id="486818at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="10"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="469" mass="52818" checksum="D6F52A02DB5CC5BC" modified="2005-11-22" version="1">MVAMQSYPYVITVSSEKGGVGKTTLATNLAIYLKALDENLPVSIFSFDNHFTVDRMFEIRGQRTTGTVADLLLETPGRDLIHTGQYGVGYIPSSPNLSDLKGTVKTPMMLARLLALSRIPGVVVIDTRPDLDILTQNALFAADRAIIPVKDMPSLENCRNIFALFEQRGLDRKSLSLIPCLVDERIKFDGPFSDQKTLLKAYAINRGYRCFETYISKSPKVESLNTNPDGKIYPILTHAKWTEVHGQFAQLAQTIITEFRATAEPRAFLFHQWLQSEEVRKKEAFFARLSGIKSECLLCGRPVSGKDSDRVSFYFEVSDGSAAGFFEEECFFRLLMTNVYNLDINLADDDPTLQIMRDAARESAFVFRPVTNGSGTTVDFHRFGLDGVHLLKKAYPLREFEGGMLTREKSRLFSLLSETFGNRLDASPDSFLLVHPVHQEKPEAILQEECYRGFARLRQRIAQQVLPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UK9</accession>
    <name>Q39UK9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512010.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1836"/>
    <dbReference type="EnsemblBacteria" id="ABB32065">
        <property type="protein sequence ID" value="ABB32065"/>
        <property type="gene ID" value="Gmet_1836"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1836"/>
    <dbReference type="eggNOG" id="ENOG5033HMA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_156489_0_0_7"/>
    <dbReference type="OMA" id="ICCEVPL"/>
    <dbReference type="OrthoDB" id="1941277at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="132" mass="15349" checksum="DDA2DD5C007070A2" modified="2005-11-22" version="1">MASLIREMTLENSLVVRFFDHTRLYYGDFYLVKVEIVCVVPLCPDYFDEHVEIEEVRRLVGDPAMYRRTVEQMGVPSTAIATVTEQLIGNFISHSLPYFSASDFPRKFLMTELARARNKRNLSARITAYHHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UP4</accession>
    <name>Q39UP4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Redox-active protein, C_GCAxxG_C_C family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32030.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1801"/>
    <dbReference type="EnsemblBacteria" id="ABB32030">
        <property type="protein sequence ID" value="ABB32030"/>
        <property type="gene ID" value="Gmet_1801"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1801"/>
    <dbReference type="eggNOG" id="ENOG5032ZHX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091283_4_0_7"/>
    <dbReference type="OMA" id="CCSQILI"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010181">
        <property type="entry name" value="CGCAxxGCC_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09719">
        <property type="entry name" value="C_GCAxxG_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32030.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="146" mass="15878" checksum="3906E4DF93047CFD" modified="2012-10-31" version="2">MNTITFDGPYLDILLMKHQGLCCSQIVVKLVLRDLGRDNPDLVRSMAALCNGFYAGVTCGVLTGASCALSLALDGSREREMQDSEFPLLLAELWDWFSVRAEKEYGGINCDEILKASPDKRACSDLLLATMEKLQSILATVGGTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UV6</accession>
    <name>Q39UV6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator, GspIIEN domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1737</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513368.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1737"/>
    <dbReference type="EnsemblBacteria" id="ABB31968">
        <property type="protein sequence ID" value="ABB31968"/>
        <property type="gene ID" value="Gmet_1737"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1737"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982667_0_0_7"/>
    <dbReference type="OMA" id="MMTIRVV"/>
    <dbReference type="OrthoDB" id="1234966at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="154"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="277" mass="30796" checksum="71D13FE8B8E1F014" modified="2005-11-22" version="1">MVQKKQLGDLLVEAGIITVKTIERALERQKGSGKRLGQVLEEMGVITGEELIDALSKQLGIKTVKGFVDYAFPPELLSLVPQDMAVQRLVFPLKLKENMLALALNDPFDQDTVDFLAKKHRLKVVPILATRQELLAAIEKHYLHGKMKDVQRQKVLVVEDTLPVATVIQVALLKEGYDVLVTHDGVDGLKSAVTEKPDMILTDATMPRMDGFGLLRALRTNPATADIPVILITSKATGEDEQRALEAGFLDFIAKPVQPIRIVTRVKRAFELTKRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UW7</accession>
    <name>Q39UW7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yaeQ</name>
        <name evidence="1" type="ordered locus">Gmet_1726</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513377.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1726"/>
    <dbReference type="EnsemblBacteria" id="ABB31957">
        <property type="protein sequence ID" value="ABB31957"/>
        <property type="gene ID" value="Gmet_1726"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1726"/>
    <dbReference type="eggNOG" id="COG4681">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096741_0_0_7"/>
    <dbReference type="OMA" id="WIELGQP"/>
    <dbReference type="OrthoDB" id="1464975at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009822">
        <property type="entry name" value="YaeQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038590">
        <property type="entry name" value="YaeQ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38784">
        <property type="entry name" value="PTHR38784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07152">
        <property type="entry name" value="YaeQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011484">
        <property type="entry name" value="YaeQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01322">
        <property type="entry name" value="YaeQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="181" mass="20099" checksum="DEE03CBEC78FFB28" modified="2005-11-22" version="1">MALPSTIYKTSIQLSDIDRGVYESLQATVAKHPSETDERLVARLLAWAIFHEPELSFTRGLCVGEEPDLWVKGPDGRVRFWVEVGLPESDRIIKASRHAEKVALLACGRALANWDQQHLPRLTGLPNLTVVSLDQAFITTLAARLERSITWSVTITEGTVYLEVDGVTHETGIRIKTGVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UX1</accession>
    <name>Q39UX1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fused isobutyryl-CoA mutase</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="6">Isobutyryl-CoA mutase</fullName>
                <shortName evidence="6">ICM</shortName>
                <ecNumber evidence="6">5.4.99.13</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="6">P-loop GTPase</fullName>
                <ecNumber evidence="6">3.6.5.-</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="6">G-protein chaperone</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="6" type="primary">icmF</name>
        <name evidence="8" type="ordered locus">Gmet_1722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible interconversion of isobutyryl-CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2-methylpropanoyl-CoA = butanoyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:13141"/>
            <dbReference type="ChEBI" id="CHEBI:57338"/>
            <dbReference type="ChEBI" id="CHEBI:57371"/>
            <dbReference type="EC" id="5.4.99.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Is composed of four functional domains: the N-terminal 5'-deoxyadenosylcobalamin binding region that is homologous to the small subunit of ICM (IcmB), a middle P-loop GTPase domain (MeaI) that likely acts as a chaperone for ICM, a structured linker region involved in dimer formation, and a C-terminal part that is homologous to the large substrate-binding subunit of ICM (IcmA).</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IcmF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.13" evidence="6"/>
    <dbReference type="EC" id="3.6.5.-" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513381.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1722"/>
    <dbReference type="EnsemblBacteria" id="ABB31953">
        <property type="protein sequence ID" value="ABB31953"/>
        <property type="gene ID" value="Gmet_1722"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1722"/>
    <dbReference type="eggNOG" id="COG1703">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009523_2_0_7"/>
    <dbReference type="OMA" id="LAMFMNT"/>
    <dbReference type="OrthoDB" id="154460at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047727">
        <property type="term" value="F:isobutyryl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034784">
        <property type="term" value="F:pivalyl-CoA mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02050">
        <property type="entry name" value="IcmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016176">
        <property type="entry name" value="Cbl-dep_enz_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033669">
        <property type="entry name" value="IcmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006099">
        <property type="entry name" value="MeMalonylCoA_mutase_a/b_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01642">
        <property type="entry name" value="MM_CoA_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51703">
        <property type="entry name" value="SSF51703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 6" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="5 6" id="KW-0170">Cobalt</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="B12-binding" evidence="7">
        <location>
            <begin position="14"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </ligand>
        <ligandPart>
            <name>Co</name>
            <dbReference type="ChEBI" id="CHEBI:27638"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="210"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="347"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="574"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="715"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="759"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="808"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="843"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="848"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="960"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="1081"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1082" mass="121166" checksum="14CD6B9586B67C83" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V13</accession>
    <name>Q39V13_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511384.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1680"/>
    <dbReference type="EnsemblBacteria" id="ABB31911">
        <property type="protein sequence ID" value="ABB31911"/>
        <property type="gene ID" value="Gmet_1680"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1680"/>
    <dbReference type="eggNOG" id="ENOG50331AJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181429_0_0_7"/>
    <dbReference type="OMA" id="KWEIARS"/>
    <dbReference type="OrthoDB" id="2052716at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223421" evidence="1">
        <location>
            <begin position="21"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="99" mass="10833" checksum="ECAE21E443A2D9E7" modified="2005-11-22" version="1">MKRTALLTAALMLSSSLAFGATKTYQATGPVLEVKDDMIVVQKGKEKWEIAKDKDTKVTGDLKVGSKVTVQYTMKAASIEAKGEKKAEKKAEKKVEKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V39</accession>
    <name>Q39V39_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenine DNA glycosylase</fullName>
            <ecNumber evidence="5">3.2.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Gmet_1654</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine: 7,8-dihydro-8-oxoguanine (8-oxo-dGTP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.</text>
            <dbReference type="EC" id="3.2.2.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.31" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511409.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1654"/>
    <dbReference type="EnsemblBacteria" id="ABB31885">
        <property type="protein sequence ID" value="ABB31885"/>
        <property type="gene ID" value="Gmet_1654"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1654"/>
    <dbReference type="eggNOG" id="COG1194">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_2_0_7"/>
    <dbReference type="OMA" id="WNNAIME"/>
    <dbReference type="OrthoDB" id="1274533at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000701">
        <property type="term" value="F:purine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044298">
        <property type="entry name" value="MIG/MutY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42944">
        <property type="entry name" value="PTHR42944"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="12">
        <location>
            <begin position="56"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="285" mass="32066" checksum="96B4EC254BB52199" modified="2005-11-22" version="1">MSLESHIREMYTSGGLTPEAATLFRQIVYGHYRRHGRTLPWRETSDPYAILVSEIMLQQTQVDRVTGKYMSFLSAFPDFRALAAAPLDAVLAAWQGLGYNRRALNLKRCSEAVVTEYGGTLPSTIAELEKLPGIGHYTARAVAAFAFSVPSAFIETNIRTVFIHHFFNDSEKVHDREIAPLVEGALDYGNPREWYYALMDYGAHLKRLHGNPSRRSAHHATQSPFKGSNRELRSLILKAILDRPGITLEEITSFLNKPQDAVLSNLKQMEAEGFIAKRKGRLFIA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V47</accession>
    <name>SSRP_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SsrA-binding protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Small protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">smpB</name>
        <name type="ordered locus">Gmet_1646</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">The tmRNA-SmpB complex associates with stalled 70S ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SmpB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31877.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511418.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V47"/>
    <dbReference type="SMR" id="Q39V47"/>
    <dbReference type="STRING" id="269799.Gmet_1646"/>
    <dbReference type="EnsemblBacteria" id="ABB31877">
        <property type="protein sequence ID" value="ABB31877"/>
        <property type="gene ID" value="Gmet_1646"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1646"/>
    <dbReference type="eggNOG" id="COG0691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108953_0_1_7"/>
    <dbReference type="OMA" id="WTNHSAR"/>
    <dbReference type="OrthoDB" id="1720952at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070929">
        <property type="term" value="P:trans-translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09294">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00023">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023620">
        <property type="entry name" value="SmpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000037">
        <property type="entry name" value="SsrA-bd_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020081">
        <property type="entry name" value="SsrA-bd_prot_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30308">
        <property type="entry name" value="PTHR30308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01668">
        <property type="entry name" value="SmpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74982">
        <property type="entry name" value="SSF74982"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00086">
        <property type="entry name" value="smpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01317">
        <property type="entry name" value="SSRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000331048" description="SsrA-binding protein">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="153" mass="17925" checksum="DC8F23042034C126" modified="2008-04-29" version="2">MGEKLICNNKKAFHDYFIEERFEAGMVLKGTEVKSLRMGKANLNDSFALVRDGEIFLHNLHINPYDFGNRQNHDPDRLRKLLMHKSEIEKLFGKIREKGYSVVPLRLYFKNGLAKVELGLAKGKKLYDKREDMKKKDQSREMAQALRERSKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V62</accession>
    <name>Q39V62_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">thrC</name>
        <name evidence="12" type="ordered locus">Gmet_1631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-homoserine = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511433.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1631"/>
    <dbReference type="EnsemblBacteria" id="ABB31862">
        <property type="protein sequence ID" value="ABB31862"/>
        <property type="gene ID" value="Gmet_1631"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1631"/>
    <dbReference type="eggNOG" id="COG0498">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015170_1_0_7"/>
    <dbReference type="OMA" id="FGRIAFQ"/>
    <dbReference type="OrthoDB" id="428821at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00065"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Thr_synth_N" evidence="11">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="PALP" evidence="10">
        <location>
            <begin position="89"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB31862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="461" mass="50556" checksum="11F701431128F16E" modified="2005-11-22" version="1">MNYISTRGAIAPIGFKDAVMMGLATDGGLLLPETIPALGRNTLESWQSLSYQDLAFNVISLFADDIPAQDLKDLIDRSYATFSHPEITPVVEKDGVYILELFHGPTLAFKDVALQLLGNLFEYLLKERGEKMNIVGATSGDTGSAAIYGVRGKDKINIFILHPHGKTSPVQALQMTTVLDPNVHNIAARGTFDDCQNIVKSLFSDLPFKEKYSLGAVNSINWARVLAQVVYYFYAYFRVAALFGQEVVFSVPTGNFGDIFAGYVAKRMGLPIRRLILATNENNILSRFINGGDYSLGDVVATVSPSMDIQLASNFERYVYYLFGENPARVREAFAALPTKGRIDFTEAEMEKVRDEFLSRSVNEDETIATIAAFHRETGYILDPHTAVGVKAALELVQDGTPAVCLATAHPAKFAEAVVRAVGFEPSRPTSLEGIEALPSRCDVLDADRDAIKAFIEKKAL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VA1</accession>
    <name>PNP_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Polyribonucleotide nucleotidyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polynucleotide phosphorylase</fullName>
            <shortName evidence="1">PNPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pnp</name>
        <name type="ordered locus">Gmet_1591</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + RNA(n+1) = a ribonucleoside 5'-diphosphate + RNA(n)</text>
            <dbReference type="Rhea" id="RHEA:22096"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyribonucleotide nucleotidyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511474.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VA1"/>
    <dbReference type="SMR" id="Q39VA1"/>
    <dbReference type="STRING" id="269799.Gmet_1591"/>
    <dbReference type="PRIDE" id="Q39VA1"/>
    <dbReference type="EnsemblBacteria" id="ABB31823">
        <property type="protein sequence ID" value="ABB31823"/>
        <property type="gene ID" value="Gmet_1591"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1591"/>
    <dbReference type="eggNOG" id="COG1185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004217_2_2_7"/>
    <dbReference type="OMA" id="LHILDVM"/>
    <dbReference type="OrthoDB" id="122725at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004654">
        <property type="term" value="F:polyribonucleotide nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01595">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012162">
        <property type="entry name" value="PNPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015848">
        <property type="entry name" value="PNPase_PH_RNA-bd_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036456">
        <property type="entry name" value="PNPase_PH_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11252">
        <property type="entry name" value="PTHR11252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03726">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005499">
        <property type="entry name" value="PNPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46915">
        <property type="entry name" value="SSF46915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="SSF54791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03591">
        <property type="entry name" value="polynuc_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000329661" description="Polyribonucleotide nucleotidyltransferase">
        <location>
            <begin position="1"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="KH" evidence="1">
        <location>
            <begin position="551"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="620"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01595"/>
        </source>
    </evidence>
    <sequence length="697" mass="75051" checksum="F0462457E36FBEE4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VE2</accession>
    <name>Q39VE2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Metal ion efflux pump, RND family, membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511518.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1548"/>
    <dbReference type="EnsemblBacteria" id="ABB31782">
        <property type="protein sequence ID" value="ABB31782"/>
        <property type="gene ID" value="Gmet_1548"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1548"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_13_1_7"/>
    <dbReference type="OMA" id="NEPLYWV"/>
    <dbReference type="OrthoDB" id="949250at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045800">
        <property type="entry name" value="HMBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19335">
        <property type="entry name" value="HMBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMBD" evidence="4">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="116"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="466" mass="49700" checksum="6D376C25B5F38D9A" modified="2005-11-22" version="1">MKLSAKVAVPVAVVLLAAAGGGGYYLWHNQKAETATGAKQGEKAAQGKVLYTCAMHPFIIKDKPGTCPICGMELIKKVEGAQADAKEMAMLEHVSLSPSQQVMANVATVEAKTMPLTKEVNAVGIVQYDQSRQAKVTAWVAGRIDRLYVNTVGAYVSKGKPVAEVYSPDLVSAQQEYLLALKSRDRFKDSPIASISQGGEGLVASARQRLLLMGVKEHQIAGLQKAGRPNIRLPIYTPLSGVVIEKIAIEGQYVNTGDPLFNIADLSTVWVDVEVYENEFSFIKLGQRVDIVSQSYPGKTFSGRVSFVYPFLDPKTRTVKVRVQLPNPGLKLKPDMFVNASVKVPLGTAVTVPVAAVMDTGKRQVAWVEMKPGMFEPRDVKVGARVGDMLQVLSGVKAGEKVAASGGYLIDSEAQLKGTGGGHAGMPGMKMEEKGAPAPPAGHEGHTPSAPPQKKGGGMDMGDMKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VF6</accession>
    <name>Q39VF6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1534</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365842.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1534"/>
    <dbReference type="EnsemblBacteria" id="ABB31768">
        <property type="protein sequence ID" value="ABB31768"/>
        <property type="gene ID" value="Gmet_1534"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1534"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_6_0_7"/>
    <dbReference type="OMA" id="SHEAVMH"/>
    <dbReference type="OrthoDB" id="881796at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="263" mass="28078" checksum="57E60B47EE0723C7" modified="2005-11-22" version="1">MPMWLTYITIGTFAGLSAGLFGVGGGLIIVPILTFMFTAQHLPEEHILHLALGTSLACIMFTSISSLRAHHRHGAVDWAVVRRISFGIIAGTYTGSWVAAQLSTRFLKGFFVLFLYYIATRMLLDIKPKPHRQLPGRTALFGVGGLIGCVSSLVGIGGGSMSVPFLVWCNVAFHRAIGTSAAIGFPIALAGAVGYVINGLQVPLPPHSFGFVYLPALFGIVVASIVTAPLGAKLAHNLPIYKLRLVFSLLVIVMGTKMLLSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VK3</accession>
    <name>Q39VK3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2 8">2.6.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">GFAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Glucosamine-6-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Hexosephosphate aminotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">L-glutamine--D-fructose-6-phosphate amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">glmS</name>
        <name evidence="11" type="synonym">glmS-2</name>
        <name evidence="11" type="ordered locus">Gmet_1487</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511580.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1487"/>
    <dbReference type="EnsemblBacteria" id="ABB31721">
        <property type="protein sequence ID" value="ABB31721"/>
        <property type="gene ID" value="Gmet_1487"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1487"/>
    <dbReference type="eggNOG" id="COG0449">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012520_5_2_7"/>
    <dbReference type="OMA" id="RECALQF"/>
    <dbReference type="OrthoDB" id="43416at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901137">
        <property type="term" value="P:carbohydrate derivative biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00164">
        <property type="entry name" value="GlmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GlmS_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="PTHR10937:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SSF53697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="SSF56235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 8 11" id="KW-0808">Transferase</keyword>
    <feature type="initiator methionine" description="Removed" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="9">
        <location>
            <begin position="2"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="286"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="10">
        <location>
            <begin position="454"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for GATase activity" evidence="8">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="For Fru-6P isomerization activity" evidence="8">
        <location>
            <position position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="609" mass="66164" checksum="A351778632944EEC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VK4</accession>
    <name>Q39VK4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="5 8">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">galE-2</name>
        <name evidence="10" type="ordered locus">Gmet_1486</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="5 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511581.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1486"/>
    <dbReference type="EnsemblBacteria" id="ABB31720">
        <property type="protein sequence ID" value="ABB31720"/>
        <property type="gene ID" value="Gmet_1486"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1486"/>
    <dbReference type="eggNOG" id="COG1087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_10_7"/>
    <dbReference type="OMA" id="ITEDTPC"/>
    <dbReference type="OrthoDB" id="1597849at2"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="9">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="330" mass="36268" checksum="6FC2C0181BF48587" modified="2005-11-22" version="1">MKILVTGGAGYIGSHVVKALGLEGHELLVYDNLSTGHEWAVMYGTLVKGDLEDRALLEKVFREFRPDAVMHFAASIQVEESVRRPLLYYGNNTAGTLNLLDVMVRTGVRCLVHSSTAAVYGIPDVVPVAETAPLAPINPYGSSKAMVEKILADLALAEDFRYVAIRYFNVAGADVACRLGQAYREATHLITRALKTAHGQYERLQIFGTDYQTPDGTCIRDYIHVDDLAAAHVLALDYLTEGGASEIVNCGYGHGFSVREVIEAVAHVTGTPFPVEETGRRPGDPPALVADSSKLRSLMKWEPQYDNLDFIIRTAWEWELALKRRESCAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VN1</accession>
    <name>Q39VN1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Biopolymer transport membrane proton channel, TolQ-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_1459</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511611.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1459"/>
    <dbReference type="EnsemblBacteria" id="ABB31693">
        <property type="protein sequence ID" value="ABB31693"/>
        <property type="gene ID" value="Gmet_1459"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1459"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_455512_0_0_7"/>
    <dbReference type="OMA" id="NHQIESF"/>
    <dbReference type="OrthoDB" id="704437at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018765">
        <property type="entry name" value="DUF2341"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006558">
        <property type="entry name" value="LamG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10102">
        <property type="entry name" value="DUF2341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00560">
        <property type="entry name" value="LamGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="SSF49899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223328" evidence="9">
        <location>
            <begin position="38"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="504"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="LamGL" evidence="10">
        <location>
            <begin position="218"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="603" mass="64422" checksum="7A828407127527A6" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VN9</accession>
    <name>Q39VN9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1451</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511618.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1451"/>
    <dbReference type="EnsemblBacteria" id="ABB31685">
        <property type="protein sequence ID" value="ABB31685"/>
        <property type="gene ID" value="Gmet_1451"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1451"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_613595_0_0_7"/>
    <dbReference type="OMA" id="PFGFFVN"/>
    <dbReference type="OrthoDB" id="1564976at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223330" evidence="1">
        <location>
            <begin position="25"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="434" mass="44946" checksum="A0FCBBBE23A10280" modified="2005-11-22" version="1">MKKKTLKTMVAAAAVLSSAAIAQAATVDINIYGASAQYLFWNTAASNFLTAKGCTSITKAEDSSKKHGITSGKACSGFGGNDVIIRYSSKASYESVRSLKGTTNPDGCPNAYQRKMADSVTAPNTLTCQTITLGASDVSGEAFVQESHGQKFGPLGGGLVDNVLTGENASGLTSYNPLVVPFGFFVNNAVTAKKCTTAAGAMSGEYCASDADCGGTAGSCGAASTIDNITRLQAVSIFSGTIADWSDFGGYFTAQPVVACLRHAGSGTAAALDFSVVRGNGWGSGLASFENPGAVWFNEGSTDLIKCVNGNSTATPSGSAIGAIGYADADQTVGAAGTSQNVKAVKYNGHFGTRYSIRNGVYDFWTTQWVYEDAARTSLAQRPVVDALVAYASSPANVPATKAKYWATKDEMKFFKGSEAEYPYLLGAINPQLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VP0</accession>
    <name>Q39VP0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511619.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1450"/>
    <dbReference type="EnsemblBacteria" id="ABB31684">
        <property type="protein sequence ID" value="ABB31684"/>
        <property type="gene ID" value="Gmet_1450"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1450"/>
    <dbReference type="HOGENOM" id="CLU_1487038_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223547" evidence="2">
        <location>
            <begin position="23"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="181" mass="18621" checksum="54F44C92FC1374C5" modified="2005-11-22" version="1">MKTITATIAAALLLGLAGNALAAYTDFSSSADVKLPGLNQSLSGGNAILTVINPIEDRKDKGIITVIAPAEKTGIVTVVEPMDFTFTQLSYSQGFFFDTSDTFGAGGSRMATIGSSSIRSMSAFFTQQPLPPIITEVAPSGPGIVTVITPANATTVPVPPALFLMGSGLAGLAGIRRKRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VT8</accession>
    <name>Q39VT8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511665.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1402"/>
    <dbReference type="EnsemblBacteria" id="ABB31636">
        <property type="protein sequence ID" value="ABB31636"/>
        <property type="gene ID" value="Gmet_1402"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1402"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084157_0_0_7"/>
    <dbReference type="OMA" id="LDPYNMD"/>
    <dbReference type="OrthoDB" id="1918722at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="289" mass="33023" checksum="1F2F20EDB6DBA818" modified="2005-11-22" version="1">MKRVLLALVLAAAFFVVNFSLDRQMANRPVVVKLGYSPSGQVLKLVAGDLKPLVAEFNVLRVVIYFGSLVEKWKSRIQLPPEYPNMFRTIETAVRLDPYNMDAYYFAQAAFTWQVGHASDVNYLLDYGMKYRTRDWQLPYFAGFNAAYFLHEYDSAATYMQRAARLSGHDLLTNLTARYFYESGREDLGIAFLRDMIARTTDKKERTIYELRLKALIAVQKLNSAVRRYRAEHGALPENLQALVKIGYLLRIPDDPYGGEFFLDKRGMVRTSSQMAMARSTGKSGGEND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VU8</accession>
    <name>AROE_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Shikimate dehydrogenase (NADP(+))</fullName>
            <shortName evidence="1">SDH</shortName>
            <ecNumber evidence="1">1.1.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroE</name>
        <name type="ordered locus">Gmet_1392</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + shikimate = 3-dehydroshikimate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.25" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513116.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VU8"/>
    <dbReference type="SMR" id="Q39VU8"/>
    <dbReference type="STRING" id="269799.Gmet_1392"/>
    <dbReference type="EnsemblBacteria" id="ABB31626">
        <property type="protein sequence ID" value="ABB31626"/>
        <property type="gene ID" value="Gmet_1392"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1392"/>
    <dbReference type="eggNOG" id="COG0169">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044063_4_1_7"/>
    <dbReference type="OMA" id="FGNPIKH"/>
    <dbReference type="OrthoDB" id="1054867at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00087"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00222">
        <property type="entry name" value="Shikimate_DH_AroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011342">
        <property type="entry name" value="Shikimate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="PTHR21089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00507">
        <property type="entry name" value="aroE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000021285" description="Shikimate dehydrogenase (NADP(+))">
        <location>
            <begin position="1"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="20"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="132"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>shikimate</name>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00222"/>
        </source>
    </evidence>
    <sequence length="286" mass="30155" checksum="5958578748435394" modified="2005-11-22" version="1">MDITGKTRVLGIIGWPVAHSLSPLMQNAALEAMGLDWIYVPFAVRPEDLASAVAGLRTLGVSGFNVTIPHKTAIIPLLDRITPEARLMGAVNTVKREGDDLVGYNTDGEGFIRSLAEDLGFVPAGRRILVLGAGGAARAAVASLARGGAATVMIANRSVARGEELVEAFQGVFGGTQFAAMPLDIPLINAEVQNFDLLVNTTSVGMGETAFEGLDISRMNPAASVYDMVYAPWETPLLAEASRGGRRCANGIGMLVAQGECALAIWTGMEPPPGIMRRRVLAALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VX0</accession>
    <name>Q39VX0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513138.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1370"/>
    <dbReference type="EnsemblBacteria" id="ABB31604">
        <property type="protein sequence ID" value="ABB31604"/>
        <property type="gene ID" value="Gmet_1370"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1370"/>
    <dbReference type="eggNOG" id="COG4095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135915_1_0_7"/>
    <dbReference type="OMA" id="LWEIYGW"/>
    <dbReference type="OrthoDB" id="1844907at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004316">
        <property type="entry name" value="SWEET_sugar_transpr"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03083">
        <property type="entry name" value="MtN3_slv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="105" mass="11176" checksum="743935317A10764C" modified="2005-11-22" version="1">MNGEIMLGLVAGAVTSIAVVPQVARAYRTKRVRDISVWQPVILVAGMILWLTYGVMIGDIPLIAANIFSIACNGILIGMKFCYRGGDNGADGGYSLGQTNQTEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W02</accession>
    <name>Q39W02_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Undecaprenyl-phosphate glycosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1337</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513169.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1337"/>
    <dbReference type="EnsemblBacteria" id="ABB31572">
        <property type="protein sequence ID" value="ABB31572"/>
        <property type="gene ID" value="Gmet_1337"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1337"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_1_2_7"/>
    <dbReference type="OMA" id="QVQNIDM"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bac_transf" evidence="2">
        <location>
            <begin position="2"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="186" mass="21373" checksum="F9C789B5D209BA55" modified="2005-11-22" version="1">MKRVFDLVLSFLLMLVFSLPMLVTALLVKLTSRGPILYWSDRVGRNNAIFRMPKFRTMRTDTPAVATHLLSDPDRWLTPIGKFLRKTSLDELPQLYSILRGDMSFVGPRPALFNQDDLVALRTEKGVHRLTPGLTGWAQINGRDELPIPVKVEYDAYYLQNRSLFFDLKIMILTAIKVLRRDGVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W16</accession>
    <name>Q39W16_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Heptapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1323"/>
    <dbReference type="EnsemblBacteria" id="ABB31558">
        <property type="protein sequence ID" value="ABB31558"/>
        <property type="gene ID" value="Gmet_1323"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1323"/>
    <dbReference type="HOGENOM" id="CLU_2682547_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="74" mass="8116" checksum="81C23A05D6C4F0D3" modified="2005-11-22" version="1">MKGEVGAFFAGKYGECPSFPLLISPHFPQTDDRFDLVDLKIETLNKKISAVAADLSAHRCDAEAHHGVCWVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W22</accession>
    <name>Q39W22_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1316</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1316"/>
    <dbReference type="EnsemblBacteria" id="ABB31552">
        <property type="protein sequence ID" value="ABB31552"/>
        <property type="gene ID" value="Gmet_1316"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1316"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_1_2_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="27"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="148" mass="16712" checksum="EA671C9BE6072F1D" modified="2005-11-22" version="1">MVCGKCEQGFPPVNLMDCDMEQLKTELAPIFAKYHDEIVAAYLFGSTASGLTSSLSDIDIAVLPRNTDKVSGATLKFHLYADLCRKLNRNDIDLMMMGLSGNLILNDEILRNGKLLYVTDHDARDDFELKVLHRCTDFKFQRRYAMGV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W35</accession>
    <name>TSAD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA N6-adenosine threonylcarbamoyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N6-L-threonylcarbamoyladenine synthase</fullName>
            <shortName evidence="1">t(6)A synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">t(6)A37 threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA threonylcarbamoyladenosine biosynthesis protein TsaD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsaD</name>
        <name type="synonym">gcp</name>
        <name type="ordered locus">Gmet_1303</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + L-threonylcarbamoyladenylate = AMP + H(+) + N(6)-L-threonylcarbamoyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="1">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512063.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W35"/>
    <dbReference type="SMR" id="Q39W35"/>
    <dbReference type="STRING" id="269799.Gmet_1303"/>
    <dbReference type="EnsemblBacteria" id="ABB31539">
        <property type="protein sequence ID" value="ABB31539"/>
        <property type="gene ID" value="Gmet_1303"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1303"/>
    <dbReference type="eggNOG" id="COG0533">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023208_0_2_7"/>
    <dbReference type="OMA" id="HLEGHIY"/>
    <dbReference type="OrthoDB" id="1257362at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="PTHR11735:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03723">
        <property type="entry name" value="T6A_TsaD_YgjD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000303374" description="tRNA N6-adenosine threonylcarbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01445"/>
        </source>
    </evidence>
    <sequence length="341" mass="35882" checksum="2F705F889AD58397" modified="2005-11-22" version="1">MLILTIETSCDETAAAVVRDGRTVLSSIVATQVKDHAVYGGVVPEIASRKHLESIPVVIDEALRTASVSLDAIEGVAVTQGPGLAGALLVGTAVAKAIAFARRLPIVGVNHIEGHLSAIFLEREVAFPFVALAVSGGHTHLYRVDGIGRYTTLGQTRDDAAGEAFDKVAKLLGLPYPGGVEIDRLAAEGDPASISFPRPLLHDGSFNFSFSGLKTAVLNHVRKNPVQEDGQQLRDLCASFQRAACDVLVTKTLLAAETEGIGRVVVAGGVACNSALRRDMAREAADRGIELAIPSPSLCSDNAAMLAVPGDFYLSRGISDGLSLDALVNWPLDTIRTRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W81</accession>
    <name>Q39W81_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc metalloprotease</fullName>
            <ecNumber evidence="9">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">rseP</name>
        <name evidence="11" type="ordered locus">Gmet_1257</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase M50B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512110.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1257"/>
    <dbReference type="EnsemblBacteria" id="ABB31493">
        <property type="protein sequence ID" value="ABB31493"/>
        <property type="gene ID" value="Gmet_1257"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1257"/>
    <dbReference type="eggNOG" id="COG0750">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025778_1_0_7"/>
    <dbReference type="OMA" id="QYMVGFG"/>
    <dbReference type="OrthoDB" id="1395197at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004387">
        <property type="entry name" value="Pept_M50_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008915">
        <property type="entry name" value="Peptidase_M50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42837">
        <property type="entry name" value="PTHR42837"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02163">
        <property type="entry name" value="Peptidase_M50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00054">
        <property type="entry name" value="TIGR00054"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="11" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="10">
        <location>
            <begin position="127"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="355" mass="38112" checksum="AC371002E32D9886" modified="2005-11-22" version="1">MTSIVSAIIVLGILIFVHEFGHFLFAKLFGVGVEKFSLGFGPKLIGKKMGETEYLISAFPLGGYVKMVGEGGGDELSDEEKARSFGEKSPLRRIGIVVAGPGFNLIFAWFVFIAVFMVGVPSATTKIGEVVKDKPAAKAGIVAGDRITAVNGKKVDRWEEMATEIAASKGPSLLVEIKRGGETKAFQLKPEMRTGKNLLGETVTSPVIGVVAAGETVIDRYPPGEAFSRGSVQTWNVIELTVLSLVRIIERAIPLDTIGGPIMIAKMAGQQAEAGGVSFLAFMALLSVNLGVLNLLPIPILDGGHLFFYLWELIFRRPVSMRAREIAQQVGLALLIGLMVLAFYNDIARYLVGNG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W88</accession>
    <name>RS2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsB</name>
        <name type="ordered locus">Gmet_1250</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512117.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W88"/>
    <dbReference type="SMR" id="Q39W88"/>
    <dbReference type="STRING" id="269799.Gmet_1250"/>
    <dbReference type="EnsemblBacteria" id="ABB31486">
        <property type="protein sequence ID" value="ABB31486"/>
        <property type="gene ID" value="Gmet_1250"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1250"/>
    <dbReference type="eggNOG" id="COG0052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040318_1_2_7"/>
    <dbReference type="OMA" id="MSVTMRQ"/>
    <dbReference type="OrthoDB" id="1623045at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_S2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_S2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_S2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_S2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_S2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12534">
        <property type="entry name" value="PTHR12534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="SSF52313"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01011">
        <property type="entry name" value="rpsB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000003966" description="30S ribosomal protein S2">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="251" mass="27765" checksum="1A26D3C48B83E369" modified="2005-11-22" version="1">MSSVTMKELLEAGVHFGHQTKRWNPKMKPYIFGARNGIYIIDLQKTVRLFKNAYSFVRECAQSGETILFVGTKKQAQDAIGEEASRCNMYYVNQRWLGGMLTNFATVKQSIDRLKRLDAMFADGTVEAYTKKEALQLEKERQKLEKTLGGIKGMGKVPGALFVIDPKNETIAINEAKKLGIPVVAVVDTNCDPDPIDYVIPGNDDAIRAIRLLTSKMADAVLEGAQARDAQLQTGEEEMAAAEGESEQVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W91</accession>
    <name>Q39W91_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IPT/TIG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1247</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512121.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1247"/>
    <dbReference type="EnsemblBacteria" id="ABB31483">
        <property type="protein sequence ID" value="ABB31483"/>
        <property type="gene ID" value="Gmet_1247"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1247"/>
    <dbReference type="eggNOG" id="ENOG5033TB2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_879290_0_0_7"/>
    <dbReference type="OMA" id="HQVQVKN"/>
    <dbReference type="OrthoDB" id="1219314at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223366" evidence="1">
        <location>
            <begin position="23"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="45"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="2">
        <location>
            <begin position="126"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="316" mass="33379" checksum="D4480647329C3361" modified="2005-11-22" version="1">MKQRVTALVALAALLPAVAAQGAPQTKSRKTSSTVAEKPAPAPAPNILSIIPAQGEPNITVTLSGTGFTAKTSAFLGTIEVPTTVVGPELLTFTIPKLPPGLYALFLKRDGATSRTYNFSIQAPKPFVESISPDTISVCSSAGERVLSITGRNFQPASQVLFDGSVVKSSFGSEQSLTFTVPQAPGGLHQVQVKNPDDTFTTPMTLTIVATPEIYSVTRSDAAVTYYKLVIEGKNFQPGTTIVVEENSLQVGLNAGAGKRLRAGAPPSGEREFLTFVDCSKLVYQRYPADPTDKDLRIQVINPNGETSSVVQVTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WC0</accession>
    <name>Q39WC0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pseudouridine synthase</fullName>
            <ecNumber evidence="3">5.4.99.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">rluB</name>
        <name evidence="6" type="ordered locus">Gmet_1217</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pseudouridine synthase RsuA family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512153.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1217"/>
    <dbReference type="EnsemblBacteria" id="ABB31454">
        <property type="protein sequence ID" value="ABB31454"/>
        <property type="gene ID" value="Gmet_1217"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1217"/>
    <dbReference type="eggNOG" id="COG1187">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024979_1_2_7"/>
    <dbReference type="OMA" id="SMEFAPF"/>
    <dbReference type="OrthoDB" id="1037615at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042092">
        <property type="entry name" value="PsdUridine_s_RsuA/RluB/E/F_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000748">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB/E/F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018496">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00093">
        <property type="entry name" value="TIGR00093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01149">
        <property type="entry name" value="PSI_RSU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S4" evidence="5">
        <location>
            <begin position="3"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="258" mass="28463" checksum="61FD1A73B6FE731F" modified="2005-11-22" version="1">MEERLQKILSQAGIASRREAERMITDGRVAVNGKPVIELGAKADSSRDAITVDGKPVTVDEKRVYILLNKPVGYVTTLKDPEGRPIVTELLKGLGVRVFPVGRLDYNTEGLLLLTNDGEWANRLAHPRHEVDKEYLVRVRGTVAREQITRLEQGIELEDGKAAPARVSVTKQSDNNTWVSITIHEGRYRQVRRMCEAVSLSVVRLRRVRYGALSMGDLKIGAYRHLTSGEVAALSDGKIGARGGAPRRRGPSAPPRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WD2</accession>
    <name>Q39WD2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Murein hydrolase-controlling membrane protein LrgA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">lrgA</name>
        <name evidence="7" type="ordered locus">Gmet_1205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512165.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1205"/>
    <dbReference type="EnsemblBacteria" id="ABB31442">
        <property type="protein sequence ID" value="ABB31442"/>
        <property type="gene ID" value="Gmet_1205"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1205"/>
    <dbReference type="eggNOG" id="COG1380">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113736_4_3_7"/>
    <dbReference type="OMA" id="MLQTFAI"/>
    <dbReference type="OrthoDB" id="1846131at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005538">
        <property type="entry name" value="LrgA/CidA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33931">
        <property type="entry name" value="PTHR33931"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03788">
        <property type="entry name" value="LrgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="122" mass="13288" checksum="94922AD1760B78CB" modified="2005-11-22" version="1">MLGSLTLILICQLIGEIITRLTRIPVPGPVIGMVLLFCGLVFFPRRMPSEVETVGGFLLRYLALLFVPAGVGVITHLDLLMKSWAPLFGAIIVGTLATIGVTGLVMKFLNRRLACAHEETRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WF8</accession>
    <name>Q39WF8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cell division protein ZapA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">zapA</name>
        <name evidence="1" type="ordered locus">Gmet_1178</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513444.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1178"/>
    <dbReference type="EnsemblBacteria" id="ABB31416">
        <property type="protein sequence ID" value="ABB31416"/>
        <property type="gene ID" value="Gmet_1178"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1178"/>
    <dbReference type="eggNOG" id="COG3027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180762_0_0_7"/>
    <dbReference type="OMA" id="GRDLQVK"/>
    <dbReference type="OrthoDB" id="2057782at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007838">
        <property type="entry name" value="Cell_div_ZapA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036192">
        <property type="entry name" value="Cell_div_ZapA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05164">
        <property type="entry name" value="ZapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102829">
        <property type="entry name" value="SSF102829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="96" mass="10376" checksum="F08484AA2D973852" modified="2005-11-22" version="1">MSVKASHRISVLGKEITVKSSASSEHVREVEALVNRKLAEAQASVPVVGDPQVPIILALMNLAESCLSLSRELEEKGQADKEVMSRLVKRIDSALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WH3</accession>
    <name>Q39WH3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Regulatory protein, CxxC_CxxC_SSSS domain-containing, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513428.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1163"/>
    <dbReference type="EnsemblBacteria" id="ABB31401">
        <property type="protein sequence ID" value="ABB31401"/>
        <property type="gene ID" value="Gmet_1163"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1163"/>
    <dbReference type="eggNOG" id="COG2331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136025_3_1_7"/>
    <dbReference type="OMA" id="TYQYQCT"/>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="83" mass="8663" checksum="19D7801F024EAADF" modified="2005-11-22" version="1">MPLYEYQCTECNKQFELRQKFSDEPAKECPSCGGPVQKLISQSGFALKGGGWYAEGYNSGGKKSEAPSCPSGGSCAGCPSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WK3</accession>
    <name>Q39WK3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513397.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1133"/>
    <dbReference type="EnsemblBacteria" id="ABB31371">
        <property type="protein sequence ID" value="ABB31371"/>
        <property type="gene ID" value="Gmet_1133"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1133"/>
    <dbReference type="eggNOG" id="COG0464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_616402_0_0_7"/>
    <dbReference type="OMA" id="WLQHRET"/>
    <dbReference type="OrthoDB" id="1115436at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="219"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="445" mass="48080" checksum="2DCA54166EEBCC89" modified="2005-11-22" version="1">MEAAARTMTEDTFSPEWERIGLLAQILAGSRQGREASTGELERLRTLQQQVEASRRQEGGWRVVAPAGLSPIEFDVLACVVAPEAEPRLGWLFQTLQPGTPTPYPTPALLQELLAMAPEETPLLYGALTESSPLRIGGLIEVEGGDPFQPVKPVPGVTARLLGRPAVTGDLPGAVLVKTPARWDDLVLPLDRVAMLREFLLWITHKATVVGEWGGGDCGGPVGLFAGPSGTGKTFAAAVLAAELGWPLYRVDLGRLVSKYIGETEKNLNRLFDAAHGQPMILQFDEADSLFSKRGEVREARDRYANMEVSHLLARIESHQGPVILTTNLRKHLDPAFARRFQVVVDFPRPDADARTRLWQRLLPPRAPLEPGVDPAFLGAAVNLTGGSIRNAALHAAYLAAGAGKPLGLGHLALAVWRELGKDGRELSPLDLGPLAPFLPREAPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WS4</accession>
    <name>Q39WS4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Periplasmically oriented, membrane-bound formate dehydrogenase, iron-sulfur cluster-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">fdnH</name>
        <name evidence="7" type="ordered locus">Gmet_1060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 4 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513236.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1060"/>
    <dbReference type="EnsemblBacteria" id="ABB31300">
        <property type="protein sequence ID" value="ABB31300"/>
        <property type="gene ID" value="Gmet_1060"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1060"/>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_0_0_7"/>
    <dbReference type="OMA" id="VPKYEWS"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015944">
        <property type="term" value="P:formate oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014603">
        <property type="entry name" value="Formate_DH_Fe-S_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12800">
        <property type="entry name" value="Fer4_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036298">
        <property type="entry name" value="FDH_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="75"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="107"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR036298-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="277" mass="31438" checksum="F69D133D89835E53" modified="2005-11-22" version="1">MSSSTIDYGKTKTFLIDTTKCTGCRGCQVACKQWNQLKGEKTTFFTGEGYQNPPQMSEFTFTRVKFKDYEKHGQNEFAFYKEMCMHCNDPACASVCPVGAFHKTPEGPVIYNAKKCIGCRFCMVACPFGVPKYEWSKAFPLVKKCTGCYSRVKNGLHPACATACPTAITYGSRDEMLKEAEKRMAAKPDRYFKVVYGKEEAGGTSVLYLTQQPLDELGFRPVTKRPLPSYTWQALRFVPGIFLTVGGTLSLVTWFQHRKDRVRREEEERNSRKEGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WW8</accession>
    <name>Q39WW8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="6">3.4.21.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">degP-2</name>
        <name evidence="8" type="ordered locus">Gmet_1014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.</text>
            <dbReference type="EC" id="3.4.21.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513185.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1014"/>
    <dbReference type="MEROPS" id="S01.453"/>
    <dbReference type="EnsemblBacteria" id="ABB31256">
        <property type="protein sequence ID" value="ABB31256"/>
        <property type="gene ID" value="Gmet_1014"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1014"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_0_7"/>
    <dbReference type="OMA" id="IIGINRQ"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="262"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="390"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="476" mass="50976" checksum="2DD0440BD8942980" modified="2005-11-22" version="1">MKHWTLKSAGKISLLTAFLLISLIFLGGCDGRSKTEFVGFPQSFADLAEKIRPAVVNISTTSTVKVPGNPFRHFFGPEEEGPFGDFFKHFFGDMPDRELKQQSLGSGIITDKDGYIVTNNHVVDNAEEIKVKISDGREFKAKVIGRDPKTDLALIKISSPFRNLPVLPLGDSDKMRVGDWVLAVGNPFGLEHTVTQGIISATGRVIGSGPYDNFLQTDAPINPGNSGGPLVNLKGEVIGINTAIVPGGQGLGFAIPSSMAKMVLKQLQEKGKVVRGWLGVTIQTVTPDLAASFGLKEAKGALVSDIAEGGPAAKGGIRRGDIILSFDGKNVKDSMELPRIVAETPVGKEVDVTVLREGKEVHCRVRVEELTEQRIAAQTEAPTDSFGMTFVDITPKVRQQLGIKEKTGVVVAGVEPGSIAEDAGIRAGDVIKEVNRKPVRNLADLSSALEKSAKGQPVLLLLNRGSQTFYVTLETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X20</accession>
    <name>Q39X20_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus minor pilin PilE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilE</name>
        <name evidence="2" type="ordered locus">Gmet_0962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514356.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0962"/>
    <dbReference type="EnsemblBacteria" id="ABB31204">
        <property type="protein sequence ID" value="ABB31204"/>
        <property type="gene ID" value="Gmet_0962"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0962"/>
    <dbReference type="eggNOG" id="COG4970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1432680_0_0_7"/>
    <dbReference type="OMA" id="VPARISC"/>
    <dbReference type="OrthoDB" id="1886924at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="189" mass="20414" checksum="CBEC60A00CAC35CB" modified="2005-11-22" version="1">MVPARISCHGGNVGCDRGFTLLELILVVAIISVMSAIAVPAFSSFYGDFRLKSVAREIRDLIRDAKLLSIQDKPCAILFDPDRCMATLVSGKGPDDEWGTGDESVVRTLTLPEGVRYGYGSRGPLKGRTKAEDGISFGDNRFVCDAGITGDWGAVYLQSQAGSAMVITVNSKEFNLGVYKWRGGAWVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X85</accession>
    <name>Q39X85_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0897</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365739.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0897"/>
    <dbReference type="EnsemblBacteria" id="ABB31139">
        <property type="protein sequence ID" value="ABB31139"/>
        <property type="gene ID" value="Gmet_0897"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0897"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030024_10_0_7"/>
    <dbReference type="OMA" id="TYWHPNF"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="87"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="264" mass="30093" checksum="D51E982D6077F88A" modified="2005-11-22" version="1">MKVRIIFAVLFGMLFPAIVSSSLPPREFSVPILLYHRFGPTVADSMTIKTSVFEEHLKYLRDNGYRVIPLRQVVDFYLKNGPAPPPKSVVIVEDDAHKSVYTDMLPLAKKYHVPVTVFIYPSAVSNAKYAMTWDQLRELKKTGLFEFQSHTFWHPNFRKDRKKLKPAEFDKLVETQLRKSRGRIEKELGVTVDMLAWPFGIYDDDLLRRAGALGYRATFTVDPHPVTQADSVMKLPRFLVSNGDQGKAFAQLLVGRGAKRSAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XF9</accession>
    <name>Q39XF9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31065.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514410.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0823"/>
    <dbReference type="EnsemblBacteria" id="ABB31065">
        <property type="protein sequence ID" value="ABB31065"/>
        <property type="gene ID" value="Gmet_0823"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0823"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_11_4_7"/>
    <dbReference type="OMA" id="MGDYFDL"/>
    <dbReference type="OrthoDB" id="1558163at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="10"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31065.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="290" mass="31284" checksum="B0EC4CDB9E0943C7" modified="2012-10-31" version="2">MAQVFIVGCGDIGKRVARLAMDKGVAVTALVRSEESAAKLHELGIETVEGHLDDPESLAGLPLRGATVFYFAPPPGGGITEPRVRAFCAAVRPGDEPAQVVYLSTSGVYGDCGDMIVTEDTPANPQTARAKRRYDAETVFRAWGKERGVPIVVLRVTGIYGPGRLPLQQLTSGQPVLFESEASYTNRIHSEDLARVCMAAAEKGEDGDIFNVSDGNPGTMTEYFNACADALGFPRPRQVTMEEAKKVMTPLMLSYVTESRRMDNAKMVGKLEVKLLYPTLQDGLKASVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XG3</accession>
    <name>Q39XG3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetyl-L-homoserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metY-2</name>
        <name evidence="5" type="ordered locus">Gmet_0819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514406.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0819"/>
    <dbReference type="EnsemblBacteria" id="ABB31061">
        <property type="protein sequence ID" value="ABB31061"/>
        <property type="gene ID" value="Gmet_0819"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0819"/>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_2_7"/>
    <dbReference type="OMA" id="YMDGHGA"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="427" mass="45948" checksum="55C341948D3D5DFE" modified="2005-11-22" version="1">MSSSWKIETQAIQGGYTPKAGDPRVVTICQSTTFKYDNADHVTKLFDLEEPGFFYTRLGNPTTDAFEQKLAMMEGGVGALATSAGQAATTLSIFNICQAGQHFVTASTLYGGTYNLFACTLPKMGIEVSFVDPEAPADEILAAFRPNTKALFAETIGNPGLNVLDFAKFSAIAQEKGVPLIIDSTFATPYLCRPFEHGANVVVHSATKYIDGLATSVGGVIVDGGNFDWGNGRFPELTEPDSSYHGLQYVKTFGNLAYIIKARVQLMRDIGTTPSPFNSFLFTNGLQTLPLRMQRHSDNALALAQFLESHPSVSWVKYPGLSSHASHDRAQKYLPQGCSGVLTFGIKGGTEAGKKFMEACRLVALVVHVGDARSCVLHPASTTHRQLTAEQQTASGVTPDLIRLSVGIEHIDDIIADVDQALAASQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XG7</accession>
    <name>Q39XG7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidylprolyl cis-trans isomerase, PpiC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0815</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514402.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0815"/>
    <dbReference type="EnsemblBacteria" id="ABB31057">
        <property type="protein sequence ID" value="ABB31057"/>
        <property type="gene ID" value="Gmet_0815"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0815"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_5_3_7"/>
    <dbReference type="OMA" id="KKEFAIN"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5007923491" evidence="2">
        <location>
            <begin position="29"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="191"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="339" mass="37411" checksum="751E78231F172D03" modified="2005-11-22" version="1">MNVFKTARRQIIALSAIALLAGTAGANAAPTAKADAKAGEAPSATTAVARVNGVDITRAELERAKKIILSRNQMASAAMNDEMSKKVEEAALNQLIAKELLFQAGKKQEIKDLDKKIQEKVAEHKARFKSQADYEKALKEMDMTEKEVETFTREDMVIGNLIETKIVANTKITDDEAKKFYNDNKDKFRREEAVRASHILVSADQKASPEEKKKAKEKAEALLKQLKGGADFAELAKKESSCPSSAQGGDLGFFGKGQMVPEFEKTAFNLKPGEVSDVVETQFGYHIIKLAEKKDAETVPFEEAKERIVQFLTQQKVQAGIGEYVDELRKKGKVEILSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XI0</accession>
    <name>Q39XI0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0802</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514389.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0802"/>
    <dbReference type="EnsemblBacteria" id="ABB31044">
        <property type="protein sequence ID" value="ABB31044"/>
        <property type="gene ID" value="Gmet_0802"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0802"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057473_3_0_7"/>
    <dbReference type="OMA" id="VFAWQLG"/>
    <dbReference type="OrthoDB" id="2018542at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223594" evidence="1">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="7"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="219" mass="23262" checksum="1E344629EE168211" modified="2005-11-22" version="1">MKRILIAAAAIAIWGMPAMSQATPARPGGYFSGFLGVSIPRDADVAGTDSGTSFNDRVEFDPGIVVGGTAGYDYGFLRLEGELSYRHSEIKSVTASDGYRFHGVDGDLGALAVMANAFVDMHNQSPITPYVGGGVGFAVLNLGNTTSTELDPLYEKGDDTVFAYQAGAGVEIALNPIMSLDLGYRYFGTSKATFDEGVVTATKFRFESHNALMGLRVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XJ0</accession>
    <name>Q39XJ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513537.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31034">
        <property type="protein sequence ID" value="ABB31034"/>
        <property type="gene ID" value="Gmet_0792"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0792"/>
    <dbReference type="eggNOG" id="COG2945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114499_0_0_7"/>
    <dbReference type="OMA" id="HERPDYT"/>
    <dbReference type="OrthoDB" id="721431at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008886">
        <property type="entry name" value="UPF0227/Esterase_YqiA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05728">
        <property type="entry name" value="UPF0227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="167" mass="18094" checksum="B6AF1D90EA536900" modified="2005-11-22" version="1">MSRGRVIFSHGKESGPWGTKISALATVARTQGFAVESIDYTDLADPDARVGRLVERCAGETGTLVLVGSSMGGYVATVASQTVNPTGLFLMAPAVYLPDYAEPDPTPSGKTYVVHGMHDEVIPMENAVRFARRHRARLFLVDGDHALVEQLPFIEELFGLFLENVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XL0</accession>
    <name>Q39XL0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoplasmic membrane protein FxsA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fxsA</name>
        <name evidence="2" type="ordered locus">Gmet_0772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513517.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0772"/>
    <dbReference type="EnsemblBacteria" id="ABB31014">
        <property type="protein sequence ID" value="ABB31014"/>
        <property type="gene ID" value="Gmet_0772"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0772"/>
    <dbReference type="eggNOG" id="COG3030">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085083_5_1_7"/>
    <dbReference type="OMA" id="WLRGMSK"/>
    <dbReference type="OrthoDB" id="2002498at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007313">
        <property type="entry name" value="FxsA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35335">
        <property type="entry name" value="PTHR35335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04186">
        <property type="entry name" value="FxsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="14292" checksum="F9DD6044DB938367" modified="2005-11-22" version="1">MLFRLFLIFSVVPVIELYLLIRVGRLIGALPTVALLLLISFAGAWLVRHQGFAILRTIQSELAAGRLPAASILDGAVVLVGGILLLTPGFFSDFLGLFFLIPATRTIIKQFLGLWLQKKLASGQVIIRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XL8</accession>
    <name>Q39XL8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0764</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513509.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0764"/>
    <dbReference type="EnsemblBacteria" id="ABB31006">
        <property type="protein sequence ID" value="ABB31006"/>
        <property type="gene ID" value="Gmet_0764"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0764"/>
    <dbReference type="eggNOG" id="ENOG5033PNR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_450438_0_0_7"/>
    <dbReference type="OMA" id="FCEYMFG"/>
    <dbReference type="OrthoDB" id="245316at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031040">
        <property type="entry name" value="CHP04442"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04442">
        <property type="entry name" value="TIGR04442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="614" mass="70448" checksum="0153C5394FF5C97E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XN1</accession>
    <name>Q39XN1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine protease, subtilase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0751</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365719.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0751"/>
    <dbReference type="EnsemblBacteria" id="ABB30993">
        <property type="protein sequence ID" value="ABB30993"/>
        <property type="gene ID" value="Gmet_0751"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0751"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_9_0_7"/>
    <dbReference type="OMA" id="ENIRVHR"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017315">
        <property type="entry name" value="Pep_S8A_subtilisin_pbac-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037901">
        <property type="entry name" value="Subtilisin_rel_Nmul_A1891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223435" evidence="6">
        <location>
            <begin position="31"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="140"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="587" mass="60590" checksum="FC47585232F29509" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XN8</accession>
    <name>RUVC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Crossover junction endodeoxyribonuclease RuvC</fullName>
            <ecNumber evidence="1">3.1.21.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Holliday junction nuclease RuvC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Holliday junction resolvase RuvC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvC</name>
        <name type="ordered locus">Gmet_0744</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).</text>
            <dbReference type="EC" id="3.1.21.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvC family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514461.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XN8"/>
    <dbReference type="SMR" id="Q39XN8"/>
    <dbReference type="STRING" id="269799.Gmet_0744"/>
    <dbReference type="EnsemblBacteria" id="ABB30986">
        <property type="protein sequence ID" value="ABB30986"/>
        <property type="gene ID" value="Gmet_0744"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0744"/>
    <dbReference type="eggNOG" id="COG0817">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091257_3_1_7"/>
    <dbReference type="OMA" id="AICHIWR"/>
    <dbReference type="OrthoDB" id="1815080at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16962">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00034">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020563">
        <property type="entry name" value="X-over_junc_endoDNase_Mg_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002176">
        <property type="entry name" value="X-over_junc_endoDNase_RuvC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30194">
        <property type="entry name" value="PTHR30194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02075">
        <property type="entry name" value="RuvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00696">
        <property type="entry name" value="RSOLVASERUVC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00228">
        <property type="entry name" value="ruvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01321">
        <property type="entry name" value="RUVC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000002760" description="Crossover junction endodeoxyribonuclease RuvC">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00034"/>
        </source>
    </evidence>
    <sequence length="164" mass="17632" checksum="AA7C1E9E37C6B536" modified="2005-11-22" version="1">MRVLGIDPGSRITGYGIIEKVGNRLVHVDNGAIHTDNHKEFALRLHRIFEGLCEVIAEYRPDAMAVEQVFLAHNAQSALKLGQARGAAIVAGVNAGLPVSEYTAMQVKQAVVGYGHARKEQVQQMVKSLLNLPEIAQADASDALAVAVCHANSAGMKNILRSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XR2</accession>
    <name>Q39XR2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LPG_synthase_C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0720"/>
    <dbReference type="EnsemblBacteria" id="ABB30962">
        <property type="protein sequence ID" value="ABB30962"/>
        <property type="gene ID" value="Gmet_0720"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0720"/>
    <dbReference type="eggNOG" id="COG4866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058411_0_0_7"/>
    <dbReference type="OMA" id="NRDRSDY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016732">
        <property type="entry name" value="UCP018688"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41373">
        <property type="entry name" value="PTHR41373"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018688">
        <property type="entry name" value="UCP018688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="LPG_synthase_C" evidence="7">
        <location>
            <begin position="29"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="296" mass="33173" checksum="4B6A39B95E71FAE8" modified="2005-11-22" version="1">MDPMTDIPGFPAARPLFLADKPFFAAVFAELQPRVSELTFANLYLFREAHDYRLTRVGDSPVVLGKGYDGEEYFLPPLGGDVAGALRVLLDAGMTLYGADEPFVSRYLAVGGVAVEEDRDAFDYLHLRQALAELPGNRFHKKKNRINYFTARHSFSVVLYGEAHRDGCLALLDEWRRVRNGIDSPSLELETKAGAEALMLADRLGLEGVVVLVEGGVAAFALGERLNRDTSVCHFEKNDPFMEGVSQLVDREFNRLLFTDCTWTNREQDLGEPGLRAAKLSYHPDELVKKYRARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XT9</accession>
    <name>Q39XT9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514084.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0693"/>
    <dbReference type="EnsemblBacteria" id="ABB30935">
        <property type="protein sequence ID" value="ABB30935"/>
        <property type="gene ID" value="Gmet_0693"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0693"/>
    <dbReference type="eggNOG" id="ENOG503397H">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1114558_0_0_7"/>
    <dbReference type="OMA" id="QIWIPST"/>
    <dbReference type="OrthoDB" id="1384412at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223503" evidence="1">
        <location>
            <begin position="25"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="249" mass="26456" checksum="E38E8AD9D24E9A11" modified="2005-11-22" version="1">MNKTLKTFSLALALVAATCGAALATPSTQIWIPSTDVQAFKTVHLGLDNYTRTSKHNGVTTNTYDAGVTVGVLPFEKLQMEVGVDYMETGTNSATDSSPFYFNAKIGTPEDALFPYSPALAVGGYNFGTKVGVTTQNITYALAAKTLPVIGRISAGYYHGSGRVLVDENGKAANDGVLLSWDRTMSEISDKLWAAVDYQSGNSGAGALNFGVCWAFSKNVSLIVGYDIYNNAYTGGKNTITTQLDINIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XU5</accession>
    <name>Q39XU5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0687</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514078.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0687"/>
    <dbReference type="EnsemblBacteria" id="ABB30929">
        <property type="protein sequence ID" value="ABB30929"/>
        <property type="gene ID" value="Gmet_0687"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0687"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_37_7"/>
    <dbReference type="OMA" id="HEVDQRD"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="172"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="232"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="446" mass="48917" checksum="14D1E3890A460E7A" modified="2005-11-22" version="1">MDGGSQPVNGSLRRRLSLWIAGVTIASGLAAGFCSYLMAFREAQELQDDQLRQMALLLGRHAQTSDAWMSPMGSIDHNDPDARIVVSPLGNVPRPPKLPPLPTTLPEGFQTLDNHGTAWRLFVFTLPSGMRLATGQMTAVRNEIARDSALFTLIPILLLVPTLSFLAAWVIRHTLMPVTHLSHQLDRRDDTNLAAVSVVGVPSEIRPFVIAINGLMQRLATAIEQQRRFIADAAHELRSPLTALTVQAENLEHGISSPEGKLRVMQLKAGLERAGKLLEQLLSLARHQSCAAPPVEVLFSHLVRQVIEDYMPFAAGKRIDFGCERFEEVTLIAPSEDLLVLARNAVDNALRYTPPGGTVDVSLYRDKEDVVFQVDDTGPGIPEGEEERMFEPFYRVTGNNETGSGLGLAIIRSIADRLGGTVTLCNREGGTGARFRYRQPLPASNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XV7</accession>
    <name>Q39XV7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ResIII domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0675</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514066.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0675"/>
    <dbReference type="REBASE" id="11546">
        <property type="entry name" value="GmeII"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30917">
        <property type="protein sequence ID" value="ABB30917"/>
        <property type="gene ID" value="Gmet_0675"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0675"/>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015668_0_0_7"/>
    <dbReference type="OMA" id="ELWAKKS"/>
    <dbReference type="OrthoDB" id="13585at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ResIII" evidence="1">
        <location>
            <begin position="2"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="898" mass="100709" checksum="73332CE17521058D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XZ2</accession>
    <name>RS8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsH</name>
        <name type="ordered locus">Gmet_0640</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S5 and S12.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514250.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XZ2"/>
    <dbReference type="SMR" id="Q39XZ2"/>
    <dbReference type="STRING" id="269799.Gmet_0640"/>
    <dbReference type="EnsemblBacteria" id="ABB30882">
        <property type="protein sequence ID" value="ABB30882"/>
        <property type="gene ID" value="Gmet_0640"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0640"/>
    <dbReference type="eggNOG" id="COG0096">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098428_0_2_7"/>
    <dbReference type="OMA" id="FDQGYIL"/>
    <dbReference type="OrthoDB" id="1692188at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01302_B">
        <property type="entry name" value="Ribosomal_S8_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_S8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_S8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="PTHR11758"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="SSF56047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000228862" description="30S ribosomal protein S8">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01302"/>
        </source>
    </evidence>
    <sequence length="132" mass="14392" checksum="06CAA3ADF3ADE67E" modified="2005-11-22" version="1">MSMTDPIADMLTRIRNASMAKLQKVDIPSSNLKVSLANVLKAEGFIKNFKVIADNKQGVLRVYLRFIDEKEPVIREIKRVSKPGSRVYVGSDEIPSVKSGMGVAILSTSKGILTDKVAREAGVGGEVICTVW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y01</accession>
    <name>RL22_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplV</name>
        <name type="ordered locus">Gmet_0631</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365700.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y01"/>
    <dbReference type="SMR" id="Q39Y01"/>
    <dbReference type="STRING" id="269799.Gmet_0631"/>
    <dbReference type="EnsemblBacteria" id="ABB30873">
        <property type="protein sequence ID" value="ABB30873"/>
        <property type="gene ID" value="Gmet_0631"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0631"/>
    <dbReference type="eggNOG" id="COG0091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083987_3_3_7"/>
    <dbReference type="OMA" id="KRIQPRA"/>
    <dbReference type="OrthoDB" id="1666043at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01331_B">
        <property type="entry name" value="Ribosomal_L22_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_L22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_L22/L17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_L22/L17_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005727">
        <property type="entry name" value="Ribosomal_L22_bac/chlpt-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="PTHR13501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="SSF54843"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01044">
        <property type="entry name" value="rplV_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000243153" description="50S ribosomal protein L22">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01331"/>
        </source>
    </evidence>
    <sequence length="110" mass="12085" checksum="B9F2DC21E25252DD" modified="2005-11-22" version="1">MEARAKLSFARLSPRKTRLVVDMVRGRGIQDALTILRFSPQPSAKLVSKLLQSAVANAEQKGASDVDRLFVKTIFVDAGPVLKRFTPRAMGRASKIRKPTSHVTVVLADK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y14</accession>
    <name>RL7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L7/L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplL</name>
        <name type="ordered locus">Gmet_0618</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514634.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y14"/>
    <dbReference type="SMR" id="Q39Y14"/>
    <dbReference type="STRING" id="269799.Gmet_0618"/>
    <dbReference type="EnsemblBacteria" id="ABB30860">
        <property type="protein sequence ID" value="ABB30860"/>
        <property type="gene ID" value="Gmet_0618"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0618"/>
    <dbReference type="eggNOG" id="COG0222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086499_3_0_7"/>
    <dbReference type="OMA" id="LEDKWGV"/>
    <dbReference type="OrthoDB" id="1822695at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00368">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_L7/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_L7/12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_L7/L12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_L7/L12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_L7/L12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="PTHR45987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="SSF48300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="SSF54736"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00855">
        <property type="entry name" value="L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000243427" description="50S ribosomal protein L7/L12">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="127" mass="13107" checksum="34AAA1D5D2DBE2CA" modified="2005-11-22" version="1">MAEITKADVVSFIENMTVLELSELVKELEEKFGVSAAAPVAVAAAAAPAAAAEAAEEKTEFDIILKSAGANKIGVIKVVRALTGLGLKEAKDLVDGAPKSVKTGVSKEEAEDAKKQLVESGAEVEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y78</accession>
    <name>Q39Y78_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system pseudopilin TklG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tklG</name>
        <name evidence="3" type="ordered locus">Gmet_0553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365682.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0553"/>
    <dbReference type="EnsemblBacteria" id="ABB30796">
        <property type="protein sequence ID" value="ABB30796"/>
        <property type="gene ID" value="Gmet_0553"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0553"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088953_1_0_7"/>
    <dbReference type="OMA" id="YSDWQFV"/>
    <dbReference type="OrthoDB" id="2044924at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="191" mass="21553" checksum="CC47847D41077531" modified="2005-11-22" version="1">MEPPRSSLLTSSSGFTYIAALMIIVIMGIMLGITGQTWRTKMKRERETELLFRGVQYQRAIRRWHQYDVTEGKPLKTTTQAARPLNDLKDLLKDPGSLSKERYLRRLFTDPFTDKEFEVVRNPQKGIIGVRVTEEDEPFKQGNFDKELEGLDQKKKYNEWVFGLPEAVTPTAGKVTQGSPASAGAGTSSVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YL0</accession>
    <name>Q39YL0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phospholipid-binding domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512393.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0421"/>
    <dbReference type="EnsemblBacteria" id="ABB30664">
        <property type="protein sequence ID" value="ABB30664"/>
        <property type="gene ID" value="Gmet_0421"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0421"/>
    <dbReference type="eggNOG" id="COG2823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082070_1_0_7"/>
    <dbReference type="OMA" id="WWVPGSR"/>
    <dbReference type="OrthoDB" id="1585236at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007055">
        <property type="entry name" value="BON_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04972">
        <property type="entry name" value="BON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50914">
        <property type="entry name" value="BON"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="3"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="97"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="BON" evidence="1">
        <location>
            <begin position="173"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="241" mass="26521" checksum="CAC11F84D9F749C9" modified="2005-11-22" version="1">MKPTEGMLRRIEAAFEREPRINLHAYPLQMEIDDGILTLEGVTESVAAKKLALELAAAEPGVAGIVDRLRVEPAEAMEDEDIRNHVCDAFVQEPAFADYAIRAFSFGAWETVRSAPREPTGVMEVEVADGIVTLNGTVGSLSHKRLAGVLAWWVPGSRDVVNGLEVSPPEEDNGDEVIDAVRLVLEKDPFVNASQIRVSCRDCVVTLEGVVPKPKEKEMAEADAWYVFGVDRVVNRLEVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YL2</accession>
    <name>Q39YL2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Squalene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">shc-2</name>
        <name evidence="5" type="ordered locus">Gmet_0419</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; hopanoid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365664.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0419"/>
    <dbReference type="EnsemblBacteria" id="ABB30662">
        <property type="protein sequence ID" value="ABB30662"/>
        <property type="gene ID" value="Gmet_0419"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0419"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019345_0_0_7"/>
    <dbReference type="OMA" id="PFMPIEF"/>
    <dbReference type="OrthoDB" id="260889at2"/>
    <dbReference type="UniPathway" id="UPA00337"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006400">
        <property type="entry name" value="Hopene-cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SQHop_cyclase_N" evidence="4">
        <location>
            <begin position="46"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="SQHop_cyclase_C" evidence="3">
        <location>
            <begin position="382"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="730" mass="81569" checksum="A76AC1319334047E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z14</accession>
    <name>Q39Z14_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase, coenzyme A pyrophosphatase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0265"/>
    <dbReference type="EnsemblBacteria" id="ABB30510">
        <property type="protein sequence ID" value="ABB30510"/>
        <property type="gene ID" value="Gmet_0265"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0265"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_5_3_7"/>
    <dbReference type="OMA" id="FPGGRWK"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="200" mass="21172" checksum="45A7651B9DB1EAC6" modified="2005-11-22" version="1">MRLHGPSLTFPGIAAGLASHPPVEISSSGMTSAAVALILREGREGLEVLFIERASHDGDPWSGDLGFPGGKIEPGDAGPRGAAERETREELGIDLATAHYLGRLADVAGAHLPIRVSCFVYGLIGNPPLTPGGEVRDAFWVSLTDLCDPDRHKDATVRFGGETFERPAIILPAEGKPALWGITYRLVMQFLALVTGEGVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-02-10" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZD0</accession>
    <name>Q39ZD0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UPF0235 protein Gmet_0145</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0145</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the UPF0235 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512730.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0145"/>
    <dbReference type="EnsemblBacteria" id="ABB30394">
        <property type="protein sequence ID" value="ABB30394"/>
        <property type="gene ID" value="Gmet_0145"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0145"/>
    <dbReference type="eggNOG" id="COG1872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130694_5_0_7"/>
    <dbReference type="OMA" id="FGRMNVN"/>
    <dbReference type="OrthoDB" id="1997369at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00634">
        <property type="entry name" value="UPF0235"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="SSF69786"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="100" mass="11098" checksum="C8D40419DC428E19" modified="2005-11-22" version="1">MKKPFYTWDGDTLVLNILGTPNAKRDAIGKVKGHQLCVSVTAIPRAGRATDHMVRFLADEFGVSVGDIQVVFGRMNVNKQLRIKAPKRLPPLIGQQEFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZF6</accession>
    <name>Q39ZF6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbamoyltransferase HypF</fullName>
            <ecNumber evidence="9">6.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">hypF</name>
        <name evidence="13" type="ordered locus">Gmet_0119</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + C-terminal L-cysteinyl-[HypE protein] + carbamoyl phosphate + H2O = AMP + C-terminal S-carboxamide-L-cysteinyl-[HypE protein] + diphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:55636"/>
            <dbReference type="Rhea" id="RHEA-COMP:14247"/>
            <dbReference type="Rhea" id="RHEA-COMP:14392"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:76913"/>
            <dbReference type="ChEBI" id="CHEBI:139126"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl phosphate + H2O = a carboxylate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; [NiFe] hydrogenase maturation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the carbamoyltransferase HypF family.</text>
    </comment>
    <dbReference type="EC" id="6.2.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514124.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0119"/>
    <dbReference type="EnsemblBacteria" id="ABB30368">
        <property type="protein sequence ID" value="ABB30368"/>
        <property type="gene ID" value="Gmet_0119"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0119"/>
    <dbReference type="eggNOG" id="COG0068">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009164_0_0_7"/>
    <dbReference type="OMA" id="VQHHYAH"/>
    <dbReference type="OrthoDB" id="48295at2"/>
    <dbReference type="UniPathway" id="UPA00335"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046944">
        <property type="term" value="P:protein carbamoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004421">
        <property type="entry name" value="Carbamoyltransferase_HypF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041440">
        <property type="entry name" value="HypF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011125">
        <property type="entry name" value="Znf_HypF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17788">
        <property type="entry name" value="HypF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07503">
        <property type="entry name" value="zf-HYPF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006256">
        <property type="entry name" value="CMPcnvr_hdrg_mat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="SSF54975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00143">
        <property type="entry name" value="hypF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="11">
        <location>
            <begin position="6"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="YrdC-like" evidence="12">
        <location>
            <begin position="200"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="21"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB30368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="760" mass="82230" checksum="A78E9972AB7F5AB2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZG3</accession>
    <name>Q39ZG3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514117.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0112"/>
    <dbReference type="EnsemblBacteria" id="ABB30361">
        <property type="protein sequence ID" value="ABB30361"/>
        <property type="gene ID" value="Gmet_0112"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0112"/>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105897_0_0_7"/>
    <dbReference type="OMA" id="CAVRFTH"/>
    <dbReference type="OrthoDB" id="2052776at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="254" mass="26810" checksum="9673E122803DB8E5" modified="2005-11-22" version="1">MNDVQRAFDLLQLKPGASPAEVKRAFRDQVAAWHPDRFSADPIMQRRAEERLRLVIEAHRSIVSYHEMRASGEMAAGHRVQGDDRGLSSPAGSFFRSVPNCVFCVVVLGCALLGLLRHGMTIHAWIYGVEMALIPALFSLAYNLAGRGNLVVRNLYLGFCLCALAVVVVDGAMIGVERSAPAGEGEVFSPRGNDGGAVGGGWPLPRGGGRDLIGEGLAPASHEPPSPRAPALPLAPMAPAAPHAPAAPLAPLAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZJ1</accession>
    <name>Q39ZJ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514779.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0084"/>
    <dbReference type="EnsemblBacteria" id="ABB30333">
        <property type="protein sequence ID" value="ABB30333"/>
        <property type="gene ID" value="Gmet_0084"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0084"/>
    <dbReference type="eggNOG" id="COG3863">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_538348_0_0_7"/>
    <dbReference type="OMA" id="WGHAAVW"/>
    <dbReference type="OrthoDB" id="500834at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024453">
        <property type="entry name" value="Peptidase_C92"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05708">
        <property type="entry name" value="Peptidase_C92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223347" evidence="1">
        <location>
            <begin position="23"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="498" mass="54760" checksum="49D2FEA79C7CB46B" modified="2005-11-22" version="1">MRRITVAVLLMAALLSPFTALAQRQAACREHLAAAHSGGRAAVNQSLAKEMTAFRTLAERALALRAETIKVGNSVHAKVDQGKPLTGDDIALLNQGITEHLTLRDEMLAVAESHECWLDASTAELSKAGITDEARLKGVMVSLASALVLYDNYLLAVSLFEGDAKLRRILNEKDPGYAVTRAALSKVTLNYNSIANRQRVRRAISFFESESKKHPALLRDGAETSYLATLIAQSPSYTMVEKVSPLYVIGRKLGFLGAATTDTLTVMEREGVNVFSMLFGNAVGLVETRKGKLALRGDVAHDVSATLRSGDILLEKTPFRLTDKLIPGYWGHAAVWIGSEAELKELGIWDNPVVARHHGEIREGRLVVEALRSGVEMNTLEHFMNVDSLGILRKAAAGRDERGRIIIQALRQVGKPYDFNFDVESKERVYCSKLVYLSYSGIDWPTKKSLGRATFSPDDVAVRAFKGGDLQLVTFYHDGKPVSDRPAVRMAELMRVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZL0</accession>
    <name>Q39ZL0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cardiolipin synthase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cls-2</name>
        <name evidence="14" type="ordered locus">Gmet_0065</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514189.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0065"/>
    <dbReference type="EnsemblBacteria" id="ABB30314">
        <property type="protein sequence ID" value="ABB30314"/>
        <property type="gene ID" value="Gmet_0065"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0065"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038053_1_0_7"/>
    <dbReference type="OMA" id="EYCQRPL"/>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008808">
        <property type="term" value="F:cardiolipin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022924">
        <property type="entry name" value="Cardiolipin_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027379">
        <property type="entry name" value="CLS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13396">
        <property type="entry name" value="PLDc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04265">
        <property type="entry name" value="bac_cardiolipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="13">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="477" mass="53501" checksum="B516CC030A81CAB4" modified="2005-11-22" version="1">MIDELALALGTAALIALSLFSAGHALIMKRDPRSSLGWIVTCLTIPLLGPFFYWGMGVNRIFRRARTWLESGRRLADPEFFKSTLEQNTATALPPGAEYLSELRRLADRVVSTPLVTGNRFTPLVNGEGAYPAMLEAIAGARRSIHLSTYIFDSDAAGRRFIDALADAARRGVDVRVIIDGLGEKYSFPRARTLMERTGIRVARFLPLRQGFYMNLRNHRKMLIIDGERAFTGGMNIGDRHMVERPLPTVVKDLHFAVAGPVVGELQQIFLEDWYFVSGELLDNRHHFPPLPAAGHAISRAIGDGPDKEFRKLFLILMGALSCATRQVQIMTPYFIPDRALVAALVTTALRGVEVTLVLPEKNNLPFVHWASRAYLWELLQQGIRVFYQPPPFVHTKLFIVDGLWSLIGSANLDPRSLRLNFELNLEVYDREFAGTLTKHVAGVLARSREVTLEQMDNRPLPEKLRDGVAKLFSPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2022-05-25" version="37" xmlns="http://uniprot.org/uniprot">
    <accession>J7LWC1</accession>
    <name>J7LWC1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase, AMP-forming</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2252"/>
    <dbReference type="EnsemblBacteria" id="AFR42830">
        <property type="protein sequence ID" value="AFR42830"/>
        <property type="gene ID" value="Gmet_2252"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2252"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_7"/>
    <dbReference type="OMA" id="FTQAYGM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="20"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="455"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="AFR42830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="552" mass="60787" checksum="F08BDF21AFAA76F8" modified="2012-10-31" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PQ0</accession>
    <name>Q39PQ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin, RelE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_A3569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="3">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="3">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514725.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3569"/>
    <dbReference type="EnsemblBacteria" id="ABB33774">
        <property type="protein sequence ID" value="ABB33774"/>
        <property type="gene ID" value="Gmet_A3569"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3569"/>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155761_1_1_7"/>
    <dbReference type="OMA" id="GEWRYRI"/>
    <dbReference type="OrthoDB" id="2036672at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05016">
        <property type="entry name" value="ParE_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="90" mass="10607" checksum="3424EF6B541DF298" modified="2005-11-22" version="1">MVWKVEIDPAARRELKKLDPQISGRVLKFLFERVARLDDPRSIGEALKGSRFGDFWKYRVGDYRIITSIEDEALVILVVRVGNRREVYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PR2</accession>
    <name>Q39PR2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513713.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3557"/>
    <dbReference type="EnsemblBacteria" id="ABB33762">
        <property type="protein sequence ID" value="ABB33762"/>
        <property type="gene ID" value="Gmet_3557"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3557"/>
    <dbReference type="eggNOG" id="ENOG5030FSN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1118916_0_0_7"/>
    <dbReference type="OMA" id="VRADQTF"/>
    <dbReference type="OrthoDB" id="1693546at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="246" mass="25442" checksum="8F0B4D7406127FD2" modified="2005-11-22" version="1">MKHAMLKKGATLLIPLMLISACTPYRSQYVGFRPAEDYVNRLVVSGVTIGGEAYADSGAAQNAFGFDIKGSGLIPVQIVMTNQGAKNMEIVSNQTFLVNDQNRYFQVVPNAVAVDRIEKSTQFASFFGSETGKGAILGAVGGAVLGAAIGIVSGQSIGEAVGKGAAIGGAGGAVAGGLKGGTSGERERSIINDIRAKGLEGKTLPAGSIASGFLFFPAEADTARELRMQLRDQNTGSLHSVVLKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PR6</accession>
    <name>Q39PR6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptide deformylase</fullName>
            <shortName evidence="2">PDF</shortName>
            <ecNumber evidence="2">3.5.1.88</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Polypeptide deformylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">def</name>
        <name evidence="3" type="synonym">def-2</name>
        <name evidence="3" type="ordered locus">Gmet_3553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:24420"/>
            <dbReference type="Rhea" id="RHEA-COMP:10639"/>
            <dbReference type="Rhea" id="RHEA-COMP:10640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:49298"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="EC" id="3.5.1.88"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe(2+) ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the polypeptide deformylase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.88" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513709.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3553"/>
    <dbReference type="EnsemblBacteria" id="ABB33758">
        <property type="protein sequence ID" value="ABB33758"/>
        <property type="gene ID" value="Gmet_3553"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3553"/>
    <dbReference type="eggNOG" id="COG0242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061901_2_1_7"/>
    <dbReference type="OMA" id="RAFSYNV"/>
    <dbReference type="OrthoDB" id="1649129at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042586">
        <property type="term" value="F:peptide deformylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00487">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.45.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00163">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023635">
        <property type="entry name" value="Peptide_deformylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036821">
        <property type="entry name" value="Peptide_deformylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10458">
        <property type="entry name" value="PTHR10458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01327">
        <property type="entry name" value="Pep_deformylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004749">
        <property type="entry name" value="Pep_def"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01576">
        <property type="entry name" value="PDEFORMYLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56420">
        <property type="entry name" value="SSF56420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00079">
        <property type="entry name" value="pept_deformyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="168" mass="18341" checksum="F1F154871561CBE6" modified="2005-11-22" version="1">MPAQPILCYPHPVLKKVSHAVAVIDDEIRGLIDDLLDTMRAGPGSVGVAAPQIGATLRVCVVDVSGSRHGKENNHGVLVMVNPEIVHREGAAIMREGCMSVPDYTGDVERATTITVRFRDGEGTEREISASGFEAVAIQHEMDHLDGILFLDRIVSLKTGLFRRKNYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PS6</accession>
    <name>Q39PS6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">tatB</name>
        <name evidence="8" type="synonym">tatA</name>
        <name evidence="10" type="ordered locus">Gmet_3543</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell inner membrane</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513699.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3543"/>
    <dbReference type="EnsemblBacteria" id="ABB33748">
        <property type="protein sequence ID" value="ABB33748"/>
        <property type="gene ID" value="Gmet_3543"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3543"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_1_5_7"/>
    <dbReference type="OMA" id="GDSAKHT"/>
    <dbReference type="OrthoDB" id="1907955at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018448">
        <property type="entry name" value="TatB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01410">
        <property type="entry name" value="tatB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="103" mass="10899" checksum="0372F2D28A260E70" modified="2005-11-22" version="1">MFGIGMPELIVILVIALIVIGPQKLPDIARSLGKGLAEFKRASDDFQRNMAEEVRNLDEREKAEKEAQTAAADPKGDPAAEVKAHGDRAAETASRGGDGAKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PS8</accession>
    <name>Q39PS8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidoglycan-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pal</name>
        <name evidence="12" type="ordered locus">Gmet_3541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Pal lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513697.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3541"/>
    <dbReference type="EnsemblBacteria" id="ABB33746">
        <property type="protein sequence ID" value="ABB33746"/>
        <property type="gene ID" value="Gmet_3541"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3541"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_9_0_7"/>
    <dbReference type="OMA" id="CSHKMDN"/>
    <dbReference type="OrthoDB" id="1544679at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02204">
        <property type="entry name" value="Pal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039001">
        <property type="entry name" value="Pal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014169">
        <property type="entry name" value="Pal_lipo_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02802">
        <property type="entry name" value="Pal_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223408" description="Peptidoglycan-associated protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="11">
        <location>
            <begin position="77"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="193" mass="20967" checksum="B2167393A219150D" modified="2005-11-22" version="1">MRKCTFGLVALLCFGLVAAGCAKKEMVKPEEAVPPVAAPQPTTPAKPAAPPVKEEPIAAQPIPEAPVKTETLQPATALDTVTATLDRIFFDFDSFVLSQAARDILSKNAEYLLKKQPNARVLIEGHCDERGSDEYNLALGEKRAKAARDYLVTLGVAANRLSIISYGEEKPLDPGHTEEAWAKNRRAEFLIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PV0</accession>
    <name>Q39PV0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Menaquinol oxidoreductase complex Cbc4, iron-sulfur cluster-binding subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbcT-1</name>
        <name evidence="5" type="ordered locus">Gmet_3519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513676.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3519"/>
    <dbReference type="EnsemblBacteria" id="ABB33724">
        <property type="protein sequence ID" value="ABB33724"/>
        <property type="gene ID" value="Gmet_3519"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3519"/>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_1_3_7"/>
    <dbReference type="OMA" id="CNFCRET"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="257" mass="28789" checksum="11F6CD5A169FB38F" modified="2005-11-22" version="1">MNRREFLKRSMVVVAGMAVPAAALHLIDPKQLLAAKPELRWAFLVDAYKCVGCGFCVKACKLENEVPYEANVSRTWVERYVVKKDGEVLIDSPKAARDGFTTKKIEVGEGKFREVKDEEIEKAFFVPKLCNQCENPPCVQVCPVGATYATADGVVLVDRKWCIGCGYCIMGCPYGVRFFHPVHKTAEKCNFCYHRITKGMKSACVDACPFGARQIGNLRDPDDPVTKVIMTERVGILKEEYGTKPQVYYIGLSKEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PV8</accession>
    <name>Q39PV8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CGGC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513667.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3511"/>
    <dbReference type="EnsemblBacteria" id="ABB33716">
        <property type="protein sequence ID" value="ABB33716"/>
        <property type="gene ID" value="Gmet_3511"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3511"/>
    <dbReference type="eggNOG" id="COG5561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147304_1_0_7"/>
    <dbReference type="OMA" id="VGIIRCQ"/>
    <dbReference type="OrthoDB" id="1563476at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014925">
        <property type="entry name" value="CGGC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08821">
        <property type="entry name" value="CGGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01078">
        <property type="entry name" value="CGGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CGGC" evidence="1">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="109" mass="11621" checksum="B2F02EF366D15003" modified="2005-11-22" version="1">MKVGIIRCQLTEDMCPGSTDFKVAREGSLAFAETGPVEIIGFLSCGGCSGKKAVTRAKMMVERGAEAIVFASCMKNGNPIGYPCPHFAAIKGAVEKKVGPETRIIDWTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PY4</accession>
    <name>Q39PY4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan L,D-transpeptidase lipoprotein, YkuD family, SPOR domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3485</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33690.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513642.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3485"/>
    <dbReference type="EnsemblBacteria" id="ABB33690">
        <property type="protein sequence ID" value="ABB33690"/>
        <property type="gene ID" value="Gmet_3485"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3485"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046834_1_1_7"/>
    <dbReference type="OMA" id="TWHVPAS"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SPOR" evidence="4">
        <location>
            <begin position="358"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33690.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="438" mass="47467" checksum="CBC5DAA1D3058C6D" modified="2012-10-31" version="2">MYRIADLPLSTACFRLIALGVCILSLQGCAVLRGAQEQSSLAPGHLAAEIERNDFPVANGDDVIGRLAVLRLEQGDTLPDIARHFGLGITALSAANPGMDVWAPEAGKPVILPLSFVLPDTPRRGIVVNVATMRLFQYKGDGASLAVSTYPVGVGTKERPTPTGPTRVYRKAARPTWHVPASIAEDHRKKGDPLPPEVPPGPENPLGEYALYLSKPGYLIHGTNKPASIGLKATNGCMRLYPENIEVLYNDTPVNTPVAIVNQPYLIGQRDGVLYLEAHTPLEDAGTLELTKVYEKLRAIEKKTGRALDWTKIRKVQAEARGIPVPILELRQGSEKGIPQTMEVGHPDTLHGRPEIPDLKPDAWYVLAADVRNELEARRIAAIINHQGPPIPARVLAKNNAYRVIAGPFADGSRARDAAKRLKIDLEIDGILIDPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="128" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PY9</accession>
    <name>Q39PY9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ordered locus">Gmet_3477</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33685.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513928.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3477"/>
    <dbReference type="EnsemblBacteria" id="ABB33685">
        <property type="protein sequence ID" value="ABB33685"/>
        <property type="gene ID" value="Gmet_3477"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3477"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_21_7"/>
    <dbReference type="OMA" id="LQSIWEG"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033479">
        <property type="entry name" value="dCache_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02743">
        <property type="entry name" value="dCache_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="18">
        <location>
            <begin position="307"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="365"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="17">
        <location>
            <begin position="440"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="493"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="17">
        <location>
            <begin position="583"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="636"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="17">
        <location>
            <begin position="709"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="783"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="924"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="1176"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="1339"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1301"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABB33685.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1443" mass="161874" checksum="58C607C84A49D434" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PZ9</accession>
    <name>Q39PZ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513917.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3466"/>
    <dbReference type="DNASU" id="3739179"/>
    <dbReference type="EnsemblBacteria" id="ABB33675">
        <property type="protein sequence ID" value="ABB33675"/>
        <property type="gene ID" value="Gmet_3466"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3466"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_3_7"/>
    <dbReference type="OMA" id="LQAVMSW"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013570">
        <property type="entry name" value="Tscrpt_reg_YsiA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08359">
        <property type="entry name" value="TetR_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="200" mass="22402" checksum="B997A3CC7F376FFD" modified="2005-11-22" version="1">MKPRKKEPTEVRRQQITEAALRIIGTKGISGATTAEIASASGISEGNLYRHFKGKEEILGSVIDKIGNDLASILDAAADIAEPLRRLEEIFKRHLSYIEEHVGIPRTIFTEEVLVLNETLREKVRGNLMHYFRGISAVIEQGQEAGALNREMDPNALATMFIGTVNFTALRWVMNKFSSKLSDEGERLWETFVKSLVCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q25</accession>
    <name>Q39Q25_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Periplasmic serine endoprotease DegP-like</fullName>
            <ecNumber evidence="6">3.4.21.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">degQ</name>
        <name evidence="8" type="ordered locus">Gmet_3437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Acts on substrates that are at least partially unfolded. The cleavage site P1 residue is normally between a pair of hydrophobic residues, such as Val-|-Val.</text>
            <dbReference type="EC" id="3.4.21.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S1C family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.107" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514665.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3437"/>
    <dbReference type="MEROPS" id="S01.480"/>
    <dbReference type="EnsemblBacteria" id="ABB33649">
        <property type="protein sequence ID" value="ABB33649"/>
        <property type="gene ID" value="Gmet_3437"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3437"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020120_1_0_7"/>
    <dbReference type="OMA" id="RALFQIQ"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001478">
        <property type="entry name" value="PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041489">
        <property type="entry name" value="PDZ_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011782">
        <property type="entry name" value="Pept_S1C_Do"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13180">
        <property type="entry name" value="PDZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17820">
        <property type="entry name" value="PDZ_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00228">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="SSF50156"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02037">
        <property type="entry name" value="degP_htrA_DO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50106">
        <property type="entry name" value="PDZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 6 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010600949" description="Periplasmic serine endoprotease DegP-like" evidence="6">
        <location>
            <begin position="22"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="265"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ" evidence="7">
        <location>
            <begin position="379"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR611782-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="472" mass="50545" checksum="27B0B5070AABC86E" modified="2005-11-22" version="1">MRICRLFIVIIALFTVVPACSKKEDKLFYETGRAEAPVKDVPKDIMATQQAFVELVKKVTPSVVNISTISRKKVEQPFFEFSPLFGDLFGDGRPRYRRDKSLGSGFIINKSGYIVTNDHVVRDAETIKVRLSNENVYDGRVVGSDPKTDIAVIKIDAKEDLPVAVLADSDKLQVGQWAIAIGNPFGLDRTVTVGVVSATGRSNMGIETYEDFIQTDASINPGNSGGPLLNVHGEVIGINTAIVAAGQGIGFAIPVNMAKQIVTQLVTKGSVSRGWLGVSIQPVTDEIAREFGLKKARGVLVADVVEGSPAAKGGIKQGDIILDFAGTEIKDAQHLQRVVAATAPGKTVQVTVFRGGREVKLSLTSASADSAGARQARPQGEEPDLLGLMVEEIPSDLRRRGVSGVVVAEVDEEGIAAEAGIQRGDIIVSVNRKGVATRAEYERAMAEAGRRGTAILLVRRGNASIFFSLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QF9</accession>
    <name>Q39QF9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_3302</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512526.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3302"/>
    <dbReference type="EnsemblBacteria" id="ABB33515">
        <property type="protein sequence ID" value="ABB33515"/>
        <property type="gene ID" value="Gmet_3302"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3302"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_7"/>
    <dbReference type="OMA" id="MDAYAIE"/>
    <dbReference type="OrthoDB" id="1058688at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="7">
        <location>
            <begin position="269"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="391" mass="40850" checksum="3B33CDF0527A86E3" modified="2005-11-22" version="1">MNEIFVVDALRTPFGSFSGMLADVDAPKLAATVMKELLAKAGLAPDTVNEVIVGQVLSGGCGQAPARQAMRGAGIPDTAHALTVNKVCGSGLKAIMLGADSIRLGESQIVIAGGMENMSLAPFFLKKARAGYRMGHSELLDLLIYDGLQDPYTGRHMGEIGEASAERGNLSREEQDAFARRSYELAQAAVTGRIFADEIVPVVKKGKKGDETIGTDEEPFKGDPSKLPSLRAAFKKDGTITAGNASTINDGAALALLTDADGLKKYNLTPKARIVASATESRHPDNFPEAPIGAIEKACAKAGLTVSDIDLFEINEAFASVALLAVKGLGLPLDKVNVNGGACAIGHPIGASGGRLAATVIRELHRRQKRYGLATLCIGGGEAVAVIFERV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QQ2</accession>
    <name>CHED2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable chemoreceptor glutamine deamidase CheD 2</fullName>
            <ecNumber evidence="1">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cheD2</name>
        <name type="ordered locus">Gmet_3209</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CheD family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512647.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QQ2"/>
    <dbReference type="SMR" id="Q39QQ2"/>
    <dbReference type="STRING" id="269799.Gmet_3209"/>
    <dbReference type="EnsemblBacteria" id="ABB33422">
        <property type="protein sequence ID" value="ABB33422"/>
        <property type="gene ID" value="Gmet_3209"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3209"/>
    <dbReference type="eggNOG" id="COG1871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087854_2_0_7"/>
    <dbReference type="OMA" id="ITLWHPA"/>
    <dbReference type="OrthoDB" id="1863047at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01440">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="PTHR35147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000251034" description="Probable chemoreceptor glutamine deamidase CheD 2">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01440"/>
        </source>
    </evidence>
    <sequence length="162" mass="17190" checksum="87FED9FB08AAE7E6" modified="2005-11-22" version="1">MSKIISVGISEHKVASDPVVLVTYGLGSCVGIALYDPEVRIGGLAHTLLPAPVREVQGAERTAKFTCWAVDLMVEELLKCGCAPERLVAKLAGGATMFEPQYRSAHGGIGERNVAAAREALERSGIPLVAEDTGGDYGRSLEFNTATGIIMVRALQQPIKQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QV7</accession>
    <name>Q39QV7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycine cleavage system H protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">gcvH</name>
        <name evidence="6" type="ordered locus">Gmet_3154</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
        <text evidence="3">Binds 1 lipoyl cofactor covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GcvH family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513870.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3154"/>
    <dbReference type="EnsemblBacteria" id="ABB33367">
        <property type="protein sequence ID" value="ABB33367"/>
        <property type="gene ID" value="Gmet_3154"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3154"/>
    <dbReference type="eggNOG" id="COG0509">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097408_2_0_7"/>
    <dbReference type="OMA" id="YRDSHEW"/>
    <dbReference type="OrthoDB" id="1773485at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005960">
        <property type="term" value="C:glycine cleavage complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06848">
        <property type="entry name" value="GCS_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00272">
        <property type="entry name" value="GcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002930">
        <property type="entry name" value="GCV_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033753">
        <property type="entry name" value="GCV_H/Fam206"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017453">
        <property type="entry name" value="GCV_H_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11715">
        <property type="entry name" value="PTHR11715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01597">
        <property type="entry name" value="GCV_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00527">
        <property type="entry name" value="gcvH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-lipoyllysine" evidence="3 4">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617453-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="124" mass="13824" checksum="AF440F9EF196AC93" modified="2005-11-22" version="1">MEIYFTKEHEWVKVKEGVALVGITEHAAHQLGDVTFVELPKVGKVVKQFEVLAAIESVKAASDIYAPVSGTVTQVNEALEERPEIVNEAAEDAGWMAIMDMEDPAELQKLMTRDQYDEYVRSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RC8</accession>
    <name>Q39RC8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514472.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2981"/>
    <dbReference type="EnsemblBacteria" id="ABB33196">
        <property type="protein sequence ID" value="ABB33196"/>
        <property type="gene ID" value="Gmet_2981"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2981"/>
    <dbReference type="eggNOG" id="ENOG502Z7PK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085032_1_0_7"/>
    <dbReference type="OMA" id="LFEMIGK"/>
    <dbReference type="OrthoDB" id="1402735at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025245">
        <property type="entry name" value="DUF4197"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13852">
        <property type="entry name" value="DUF4197"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223287" evidence="1">
        <location>
            <begin position="23"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="246" mass="26445" checksum="C4EAD25DFF13B546" modified="2005-11-22" version="1">MRYILVSILSLSLIISASPSQAGFLDDLTRQAAPLLQGGMGSSLDDSTIIKGLKEALATGTERAVNEVAKPDGYFGNSLIKIMLPDKIQKVADLLGTVGYQRQVDEFVLSMNRAAEKAAPQAAHFFGDAIRDMSVEDARGLLNGGDRAATDFFEKKTRGKLYDAFKPTVGKTMGEVGTVKAFQDMVGKYQALPLAAFGGKPSLDLNDYVTNKALDGLFTMVAAEEKKIRTNPAARTTDLLKTVFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RD1</accession>
    <name>Q39RD1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2978</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514469.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2978"/>
    <dbReference type="EnsemblBacteria" id="ABB33193">
        <property type="protein sequence ID" value="ABB33193"/>
        <property type="gene ID" value="Gmet_2978"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2978"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067676_4_0_7"/>
    <dbReference type="OMA" id="SVARRYW"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="209" mass="23847" checksum="1D6B1EC527755DB2" modified="2005-11-22" version="1">MIPITDSRIEEYLMGLAPEDNPSLLAMESRAKALGFPIVDRLVGRFLYILTRIKQPRLVVELGSGFGYSAWWFARAISITGKVVMTDYSPTNIAYAREMFQESGLSDRVEFRVGDALNIGRDYRDIDILFIDLDKHQYREAMEAMIPHLAPHALVIADNVLWYGKVVEGEDDPETRGIRDFNDFMTGRKDFFTSILPLRDGVMVAYRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RE4</accession>
    <name>Q39RE4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2965"/>
    <dbReference type="EnsemblBacteria" id="ABB33180">
        <property type="protein sequence ID" value="ABB33180"/>
        <property type="gene ID" value="Gmet_2965"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2965"/>
    <dbReference type="eggNOG" id="ENOG5032TED">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112905_0_0_7"/>
    <dbReference type="OMA" id="YLCMATH"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="214" mass="24418" checksum="EB68CD9A72DEB8CD" modified="2005-11-22" version="1">MNEPITNVTLRVHVGDYIKEITHERLADFADLTGLDAVAPNRYSWLLVVDMLVNLEVNGIDPTQIVQEIKALESSSHTSFVKPATQFKHPPLHPLWHKHYFSAHFVPHNIHAELNRGGKLENLVNEVLDPNKSPIITREMINELAHRVVHEPFEARSDEGRMTGEWLIFAKQDGNNYYLCMATHDAGDQAIYDKLAYAVKRQFPMLEPFASART</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RF3</accession>
    <name>Q39RF3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512889.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2954"/>
    <dbReference type="EnsemblBacteria" id="ABB33171">
        <property type="protein sequence ID" value="ABB33171"/>
        <property type="gene ID" value="Gmet_2954"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2954"/>
    <dbReference type="HOGENOM" id="CLU_1287289_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223188" evidence="2">
        <location>
            <begin position="27"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="214" mass="23679" checksum="95A66F459BE41C0C" modified="2005-11-22" version="1">MSHRAATKRIISALGLLLIASASADAFVFDVWKSGMKPDRVIEAGKKKDVSVKLAGGGLFSKKEPEDLAVKVEYQCDTKLMGYDARILFSFAPLSRVLHTLRVTVVLPMSSEKADMDVLADTIARQLDTKYRDQGEPAAESMIGGLVDKVRDVKRRTWKGGGDTVTMESHWKMMGGEVVVLYVDDKLAEKAAVEDRRVREKKLERSSGGDRSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RG9</accession>
    <name>Q39RG9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fumarylacetoacetate hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycgM</name>
        <name evidence="2" type="ordered locus">Gmet_2937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512873.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2937"/>
    <dbReference type="EnsemblBacteria" id="ABB33155">
        <property type="protein sequence ID" value="ABB33155"/>
        <property type="gene ID" value="Gmet_2937"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2937"/>
    <dbReference type="eggNOG" id="COG0179">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028458_5_0_7"/>
    <dbReference type="OMA" id="YALSIDM"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="SSF56529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAA_hydrolase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="218" mass="23154" checksum="7FFA2597ED479157" modified="2005-11-22" version="1">MTFATLAGSATEYPIGKILCIGRNYAEHIKELGNETPDAPVIFTKPATSVIGDGDAIVIPPYSRDCHHEAELAVLIGTAGKDIPVERALEHVAGYGVAIDLTLRDVQAELKKKGLPWDIAKGFDTACPLSPFVPADRVADPQDLRIILTVNGETRQDGSTSLMIHTVREIISHMSGIFTLEPGDVILTGTPAGVSPIVSGDRLVAEIPGVARLQVSVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RK2</accession>
    <name>Q39RK2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Phosphoribosylamine--glycine ligase</fullName>
            <ecNumber evidence="2 7">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GARS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glycinamide ribonucleotide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoribosylglycinamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">purD</name>
        <name evidence="10" type="ordered locus">Gmet_2904</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-beta-D-ribosylamine + ATP + glycine = ADP + H(+) + N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GARS family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.13" evidence="2 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512840.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2904"/>
    <dbReference type="EnsemblBacteria" id="ABB33122">
        <property type="protein sequence ID" value="ABB33122"/>
        <property type="gene ID" value="Gmet_2904"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2904"/>
    <dbReference type="eggNOG" id="COG0151">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027420_3_1_7"/>
    <dbReference type="OMA" id="KATVCKY"/>
    <dbReference type="OrthoDB" id="932854at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00125"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004637">
        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009113">
        <property type="term" value="P:purine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00138">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020561">
        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000115">
        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020560">
        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037123">
        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020559">
        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020562">
        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43472">
        <property type="entry name" value="PTHR43472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01071">
        <property type="entry name" value="GARS_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02843">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02844">
        <property type="entry name" value="GARS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01210">
        <property type="entry name" value="GARS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00877">
        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="107"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="423" mass="44375" checksum="9F9F45EF42F19D2E" modified="2005-11-22" version="1">MKVLVVGGGGREHALVWKIAQSPLVGKVYCAPGNPGIGALAENVPLTVDDLPGLLAFAKEKEIGLTVVGPELPLSLGIVDLFEEHGLLVFGARRNAAIIEASKAFSKDLMKKYGVPTAAYDVFTEVDPAVAFIDKVGVPIVIKADGLAAGKGVIIAQSRDEAVATVNDMLSGNAFGSAGSRVVIEEFLVGEEASFLAFTDGKQIIPLASAQDHKAVFDGDQGPNTGGMGAYSPAPVVTQTIHDFAMAEVMRRTVDGMAAEGRPYRGVLYAGLMINGSDVKVLEFNARFGDPECQPLLMRMKSDIVPVLLGVARGDLSGVAIEWHDKAAVCVVMAAEGYPADYRKGDEIRGLDEAAAIDDLYVFHAGTAAGDGKIVTAGGRVLGVTGLGATVKDAIDRAYRGVAKICWEGVHFRKDIGAKALKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RY1</accession>
    <name>Q39RY1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2775</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511686.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2775"/>
    <dbReference type="EnsemblBacteria" id="ABB32993">
        <property type="protein sequence ID" value="ABB32993"/>
        <property type="gene ID" value="Gmet_2775"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2775"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1774757_0_0_7"/>
    <dbReference type="OMA" id="EEHDIYP"/>
    <dbReference type="OrthoDB" id="1608241at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005361">
        <property type="entry name" value="UPF0158"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03682">
        <property type="entry name" value="UPF0158"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="145" mass="17539" checksum="8CF34B785058186F" modified="2005-11-22" version="1">MGFMRDVEIVWDDLLEAFDNPDEGIMYFLDRETGEIFAVPADYEDEEFWRDLEASGERFIQIPAFDYDQERLLLHEFIRGVENEALKRMLERAFEGKKPFGKLDEILSFYPEEFDRFMAMKEEIISERIRRWLEEHDLFGAEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S60</accession>
    <name>Q39S60_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Carbon starvation protein CstA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cstA-2</name>
        <name evidence="11" type="ordered locus">Gmet_2696</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511765.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2696"/>
    <dbReference type="EnsemblBacteria" id="ABB32914">
        <property type="protein sequence ID" value="ABB32914"/>
        <property type="gene ID" value="Gmet_2696"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2696"/>
    <dbReference type="eggNOG" id="COG1966">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010531_2_0_7"/>
    <dbReference type="OMA" id="GTISGFH"/>
    <dbReference type="OrthoDB" id="457782at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025299">
        <property type="entry name" value="CstA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003706">
        <property type="entry name" value="CstA_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02554">
        <property type="entry name" value="CstA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13722">
        <property type="entry name" value="CstA_5TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="490"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="CstA" evidence="9">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="CstA_5TM" evidence="10">
        <location>
            <begin position="418"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="615" mass="65963" checksum="B78E224DC2C69694" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S61</accession>
    <name>Q39S61_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydroxypyruvate reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hprA</name>
        <name evidence="5" type="ordered locus">Gmet_2695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511766.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2695"/>
    <dbReference type="EnsemblBacteria" id="ABB32913">
        <property type="protein sequence ID" value="ABB32913"/>
        <property type="gene ID" value="Gmet_2695"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2695"/>
    <dbReference type="eggNOG" id="COG1052">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_1_3_7"/>
    <dbReference type="OMA" id="KMKPNCI"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2-Hacid_dh" evidence="3">
        <location>
            <begin position="24"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="2-Hacid_dh_C" evidence="4">
        <location>
            <begin position="111"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="330" mass="35202" checksum="8846EBCA8B3E3249" modified="2005-11-22" version="1">MGERTRIVILDGYTINPGDNPWTPVEEYGDCTIHDRTPPELKLERARDAEIILTSKVKLDEATIAALPRLRYISLLATGYNNVDVAAAGRRGIPVSNVPAYSTESVAQTAFALLLELTTRVGLHDAAVRGGEWSHCPDHSFWKTSIVELDGLTLGIVGYGAIGRAVARIAQAFGMRTIAHAPRIPADPGPVPVRFVSLEELFATADVVTLNCPQTPENTEFVNEGLLSLMKRSAYLINVARGGLVNEADLARALRDGTLAGAGLDVVAHEPMLPDNPLLAAPNCIFTPHLAWASLAARRRLTGVVAANVAAFLAGSPINVVNGPWLAGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S78</accession>
    <name>Q39S78_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Universal stress protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">usp-2</name>
        <name evidence="4" type="ordered locus">Gmet_2678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the universal stress protein A family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511783.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2678"/>
    <dbReference type="EnsemblBacteria" id="ABB32896">
        <property type="protein sequence ID" value="ABB32896"/>
        <property type="gene ID" value="Gmet_2678"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2678"/>
    <dbReference type="eggNOG" id="COG0589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049301_11_2_7"/>
    <dbReference type="OMA" id="RSAHFYG"/>
    <dbReference type="OrthoDB" id="2040681at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006015">
        <property type="entry name" value="Universal_stress_UspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006016">
        <property type="entry name" value="UspA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00582">
        <property type="entry name" value="Usp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006276">
        <property type="entry name" value="UspA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01438">
        <property type="entry name" value="UNVRSLSTRESS"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Usp" evidence="3">
        <location>
            <begin position="4"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR006276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="149" mass="16917" checksum="44EE41EBF05851A9" modified="2005-11-22" version="1">MKTFSTIVFPTDFSENSEYAFDHALTLARQFNARLVVVHVINEPVDLRGFYVPHVSFEKLEEEIVAAAEKMMEKFCRTKLKDYANFTSSIVSGIPYDEILKKADEENASLVVMGTHGRRGIDHFLFGSTAERVVRNAKCPVMTVRPPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SE4</accession>
    <name>Q39SE4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2611</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511850.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2611"/>
    <dbReference type="EnsemblBacteria" id="ABB32830">
        <property type="protein sequence ID" value="ABB32830"/>
        <property type="gene ID" value="Gmet_2611"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2611"/>
    <dbReference type="eggNOG" id="ENOG5033NYX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2058010_0_0_7"/>
    <dbReference type="OMA" id="FPRWIAV"/>
    <dbReference type="OrthoDB" id="2085049at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="119" mass="13368" checksum="89CD3E17328105D6" modified="2005-11-22" version="1">MSPEGRNERLAAMVKEHLDARADALDDRTAARLRTIRLQAVESAERKMGWFRFPRWIAVGGLATAAVAVLAVSLWMTGPRRESTVATADDIEIVAAQEQMQFYEDIEFYRWLAAQENGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SM6</accession>
    <name>Q39SM6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514524.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2527"/>
    <dbReference type="EnsemblBacteria" id="ABB32748">
        <property type="protein sequence ID" value="ABB32748"/>
        <property type="gene ID" value="Gmet_2527"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2527"/>
    <dbReference type="eggNOG" id="ENOG502ZSB6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_194458_2_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223070" evidence="2">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="81" mass="8308" checksum="6F75C3AA01E518B8" modified="2005-11-22" version="1">MKKVLSTITAALVAISFAGIVCAAEPVKTEAPVAPAAGEVKKEEKKPAKAHKKHKKAKKAKKAVKKEEAPAAAPAEAPAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SQ0</accession>
    <name>Q39SQ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Antitoxin, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2502</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514645.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2502"/>
    <dbReference type="EnsemblBacteria" id="ABB32724">
        <property type="protein sequence ID" value="ABB32724"/>
        <property type="gene ID" value="Gmet_2502"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2502"/>
    <dbReference type="eggNOG" id="COG2336">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_150554_3_0_7"/>
    <dbReference type="OMA" id="DKDEWEW"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51740">
        <property type="entry name" value="SPOVT_ABRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="3">
        <location>
            <begin position="3"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="84" mass="9724" checksum="6DCD410C9A83AC4E" modified="2005-11-22" version="1">MRTNIIRIGNSQGIRIPKVLLEQSHLGAEVELEVEDEKIIIRSASRPRQGWGEKFQLMAESGDDRMLNGDAGEQTEWDKDEWEW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SQ3</accession>
    <name>HTPG_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chaperone protein HtpG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein HtpG</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">High temperature protein G</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">htpG</name>
        <name type="ordered locus">Gmet_2498</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Molecular chaperone. Has ATPase activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514648.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SQ3"/>
    <dbReference type="SMR" id="Q39SQ3"/>
    <dbReference type="STRING" id="269799.Gmet_2498"/>
    <dbReference type="PRIDE" id="Q39SQ3"/>
    <dbReference type="EnsemblBacteria" id="ABB32721">
        <property type="protein sequence ID" value="ABB32721"/>
        <property type="gene ID" value="Gmet_2498"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2498"/>
    <dbReference type="eggNOG" id="COG0326">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006684_3_0_7"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="246194at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="PTHR11528"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="SSF110942"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0346">Stress response</keyword>
    <feature type="chain" id="PRO_0000236995" description="Chaperone protein HtpG">
        <location>
            <begin position="1"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="A; substrate-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="B" evidence="1">
        <location>
            <begin position="350"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="C" evidence="1">
        <location>
            <begin position="567"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00505"/>
        </source>
    </evidence>
    <sequence length="650" mass="74043" checksum="083ECD4AD97C6D40" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SV3</accession>
    <name>Q39SV3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dioxygenase</fullName>
            <ecNumber evidence="5">1.13.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2446</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="5">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the carotenoid oxygenase family.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512454.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2446"/>
    <dbReference type="EnsemblBacteria" id="ABB32671">
        <property type="protein sequence ID" value="ABB32671"/>
        <property type="gene ID" value="Gmet_2446"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2446"/>
    <dbReference type="eggNOG" id="COG3670">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016472_6_3_7"/>
    <dbReference type="OMA" id="SYRNRWV"/>
    <dbReference type="OrthoDB" id="389495at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004294">
        <property type="entry name" value="Carotenoid_Oase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10543">
        <property type="entry name" value="PTHR10543"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03055">
        <property type="entry name" value="RPE65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="517" mass="58286" checksum="6E1EE621F540A73D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SW4</accession>
    <name>KDPC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Potassium-transporting ATPase KdpC subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP phosphohydrolase [potassium-transporting] C chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Potassium-binding and translocating subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Potassium-translocating ATPase C chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kdpC</name>
        <name type="ordered locus">Gmet_2435</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KdpC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512465.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SW4"/>
    <dbReference type="SMR" id="Q39SW4"/>
    <dbReference type="STRING" id="269799.Gmet_2435"/>
    <dbReference type="EnsemblBacteria" id="ABB32660">
        <property type="protein sequence ID" value="ABB32660"/>
        <property type="gene ID" value="Gmet_2435"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2435"/>
    <dbReference type="eggNOG" id="COG2156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077094_2_0_7"/>
    <dbReference type="OMA" id="KYFWPRP"/>
    <dbReference type="OrthoDB" id="1912405at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00276">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003820">
        <property type="entry name" value="KdpC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30042">
        <property type="entry name" value="PTHR30042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02669">
        <property type="entry name" value="KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001296">
        <property type="entry name" value="K_ATPase_KdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00681">
        <property type="entry name" value="kdpC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000022286" description="Potassium-transporting ATPase KdpC subunit">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00276"/>
        </source>
    </evidence>
    <sequence length="189" mass="19956" checksum="07F0DD6BD23138F8" modified="2005-11-22" version="1">MNDIKPAIMMVLVFTIICGGIYPAVVTGIAQAVFPKEATGSFITDRSGREIGSALIGQPFSDSKYFWPRPSATTDFGYNPAASGGSNSGPTNPDYLKTVANRVKALKDTGVSTGIPTDLVQASASGLDPHISPEAASVQIPRVAKARGMMEDKVRRLVSGHTEDRQFGIIGSPRVNVLALNLALDRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SW7</accession>
    <name>Q39SW7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2432</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366051.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2432"/>
    <dbReference type="EnsemblBacteria" id="ABB32657">
        <property type="protein sequence ID" value="ABB32657"/>
        <property type="gene ID" value="Gmet_2432"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2432"/>
    <dbReference type="eggNOG" id="ENOG50324BI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106310_3_0_7"/>
    <dbReference type="OMA" id="YGIHYIY"/>
    <dbReference type="OrthoDB" id="1212262at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032033">
        <property type="entry name" value="Cytochrome_P460"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038142">
        <property type="entry name" value="Cytochrome_P460_sp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16694">
        <property type="entry name" value="Cytochrome_P460"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223232" evidence="1">
        <location>
            <begin position="22"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_P460" evidence="2">
        <location>
            <begin position="28"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="157" mass="17315" checksum="13D70EE1B72524AB" modified="2005-11-22" version="1">MRRLAGVTAVAAILAASAAFAAEKVALPKGYEKWGKSSEKVINDKTSLFYGIHNIYVDKKTMPAYKKGGPYPEGSRFVVVQYTIRNEGGKPVKGKKSMVVLMTKDKKQSATGGWLFAGFTPEGKPSGIDPVKNCFECHQKEAKERDFVISRYADFKK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SY1</accession>
    <name>CHEB3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-glutamate methylesterase/protein-glutamine glutaminase 3</fullName>
            <ecNumber evidence="1">3.1.1.61</ecNumber>
            <ecNumber evidence="1">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cheB3</name>
        <name type="ordered locus">Gmet_2418</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="1"/>
    <dbReference type="EC" id="3.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512482.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SY1"/>
    <dbReference type="SMR" id="Q39SY1"/>
    <dbReference type="STRING" id="269799.Gmet_2418"/>
    <dbReference type="EnsemblBacteria" id="ABB32643">
        <property type="protein sequence ID" value="ABB32643"/>
        <property type="gene ID" value="Gmet_2418"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2418"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_7"/>
    <dbReference type="OMA" id="HAMAQTT"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264278" description="Protein-glutamate methylesterase/protein-glutamine glutaminase 3">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="5"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="1">
        <location>
            <begin position="165"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <sequence length="355" mass="38381" checksum="FC0A22EA9DD4F139" modified="2005-11-22" version="1">MKKIKVLIVDDSAVVRQTMADILASDPHIEVMAPAADPFIAAERMREQVPDVITLDVEMPRMDGITFLKKIMSQHPIPVVMCSTLTESGSETAVKALEYGAVEIIQKPKLGTKQFLEESRVRICDAVKAASQARLRKITPRTGKEIAPKLSADVILEKPGSKAMIQTTEKVVVVGASTGGTEALRVFLEALPADSPPIVIVQHMPEGFTRAFAQRLDGICRITVKEAADNDTVMRGRALIAPGNRHTLLKRSGARYYVEIKDGPLVSRHRPSVDVLFRSAARYAGKNAVGVIMTGMGDDGASGMKEMRDAGAVTIAQDEATCIVFGMPNEAIKRGGADRVIPLDTIAREVLRLCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T01</accession>
    <name>Q39T01_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Queuine tRNA-ribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">tgt</name>
        <name evidence="6" type="synonym">tgt-1</name>
        <name evidence="6" type="ordered locus">Gmet_2398</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>7-aminomethyl-7-carbaguanine + guanosine(34) in tRNA = 7-aminomethyl-7-carbaguanosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:24104"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:58703"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="EC" id="2.4.2.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.29" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512502.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2398"/>
    <dbReference type="EnsemblBacteria" id="ABB32623">
        <property type="protein sequence ID" value="ABB32623"/>
        <property type="gene ID" value="Gmet_2398"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2398"/>
    <dbReference type="eggNOG" id="COG0343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022060_0_1_7"/>
    <dbReference type="OMA" id="RRDFYPI"/>
    <dbReference type="OrthoDB" id="1165356at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:queuine tRNA-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101030">
        <property type="term" value="P:tRNA-guanine transglycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="SSF51713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGT" evidence="5">
        <location>
            <begin position="13"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="4">
        <location>
            <begin position="91"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="4">
        <location>
            <begin position="244"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding; important for wobble base 34 recognition" evidence="4">
        <location>
            <begin position="268"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="368" mass="41676" checksum="2A26DD02E6698F89" modified="2005-11-22" version="1">MKFTLNKKDRKTAARRGTLVTPHGTIETPIFMPVGTHAAMKAMTPVQVKETGAQIILSNTYHLHLRPGEELVAKAGGLHSFMAWDGPILTDSGGFQVFSLPNKRITEEGAYFKHEVSGEEVFLDPARAIAIQEDLGADIIMAFDECIPYPCDRKYAAKSTRKTLRWAEQCKKAQTRKDQALFGIVQGSVFEDLRAMCAKELVQMDFPGYAIGGVSVGEGLDLLKKVVEYTAPYLPENKPRYLMGVGLPEDILESVERGMDMFDCVIPTRYARSATLFTNRGKIRLTNRKYRRDFYPIEPNCTCYTCRNFTRAYIHHLFNANEVLSAILASIHNVHFYLNMMAEIRRAIEEGRFTDYKREFLESYLKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T03</accession>
    <name>Q39T03_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Succinate dehydrogenase/fumarate reductase, flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">frdA</name>
        <name evidence="6" type="ordered locus">Gmet_2396</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512504.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2396"/>
    <dbReference type="EnsemblBacteria" id="ABB32621">
        <property type="protein sequence ID" value="ABB32621"/>
        <property type="gene ID" value="Gmet_2396"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2396"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_7_0_7"/>
    <dbReference type="OMA" id="WRRIKVP"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011280">
        <property type="entry name" value="Succ_DH/Fum_Rdt_flav_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF53">
        <property type="entry name" value="PTHR11632:SF53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01811">
        <property type="entry name" value="sdhA_Bsu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="36"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="5">
        <location>
            <begin position="502"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="637" mass="70702" checksum="AC54F1AF74BC5ADB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T19</accession>
    <name>Q39T19_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514761.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2380"/>
    <dbReference type="EnsemblBacteria" id="ABB32605">
        <property type="protein sequence ID" value="ABB32605"/>
        <property type="gene ID" value="Gmet_2380"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2380"/>
    <dbReference type="HOGENOM" id="CLU_137819_0_0_7"/>
    <dbReference type="OMA" id="KAPEWHN"/>
    <dbReference type="OrthoDB" id="1781550at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023813">
        <property type="entry name" value="CHP03987"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03987">
        <property type="entry name" value="TIGR03987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="128" mass="14430" checksum="6EFDB89EA7525245" modified="2005-11-22" version="1">MLKLGIIYMNLALLFYTYAVFNGRREGLHRKHLIVFGIGLLFDYLGTHQMSLYARAFGKAPEWHNLTGILSLAGMGFHFLLALAASLARRAERVNRTFHRVSLTIYTLWCIAFASGALAGMGRIMARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T42</accession>
    <name>Q39T42_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Outer membrane protein assembly factor BamA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yaeT</name>
        <name evidence="6" type="synonym">bamA</name>
        <name evidence="8" type="ordered locus">Gmet_2357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Part of the Bam complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BamA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513263.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2357"/>
    <dbReference type="EnsemblBacteria" id="ABB32582">
        <property type="protein sequence ID" value="ABB32582"/>
        <property type="gene ID" value="Gmet_2357"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2357"/>
    <dbReference type="eggNOG" id="COG4775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007664_1_1_7"/>
    <dbReference type="OMA" id="IFMPAFG"/>
    <dbReference type="OrthoDB" id="258122at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01430">
        <property type="entry name" value="OM_assembly_BamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010827">
        <property type="entry name" value="BamA/TamA_POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023707">
        <property type="entry name" value="OM_assembly_BamA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="PTHR12815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF23">
        <property type="entry name" value="PTHR12815:SF23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07244">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006076">
        <property type="entry name" value="OM_assembly_OMP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03303">
        <property type="entry name" value="OM_YaeT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 6" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019135" description="Outer membrane protein assembly factor BamA" evidence="6">
        <location>
            <begin position="25"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="27"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="99"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="179"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="270"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="7">
        <location>
            <begin position="351"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="752" mass="82479" checksum="D7F6420ABB0F1B87" modified="2005-11-22" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T49</accession>
    <name>LPXB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Lipid-A-disaccharide synthase</fullName>
            <ecNumber evidence="1">2.4.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxB</name>
        <name type="ordered locus">Gmet_2350</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a lipid X + a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a lipid A disaccharide + H(+) + UDP</text>
            <dbReference type="Rhea" id="RHEA:67828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="ChEBI" id="CHEBI:176338"/>
            <dbReference type="ChEBI" id="CHEBI:176343"/>
            <dbReference type="EC" id="2.4.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LpxB family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.182" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366042.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T49"/>
    <dbReference type="SMR" id="Q39T49"/>
    <dbReference type="STRING" id="269799.Gmet_2350"/>
    <dbReference type="CAZy" id="GT19">
        <property type="family name" value="Glycosyltransferase Family 19"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32575">
        <property type="protein sequence ID" value="ABB32575"/>
        <property type="gene ID" value="Gmet_2350"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2350"/>
    <dbReference type="eggNOG" id="COG0763">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036577_3_1_7"/>
    <dbReference type="OMA" id="PTVWAWR"/>
    <dbReference type="OrthoDB" id="1258510at2"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008915">
        <property type="term" value="F:lipid-A-disaccharide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00392">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003835">
        <property type="entry name" value="Glyco_trans_19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30372">
        <property type="entry name" value="PTHR30372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02684">
        <property type="entry name" value="LpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00215">
        <property type="entry name" value="lpxB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000255183" description="Lipid-A-disaccharide synthase">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00392"/>
        </source>
    </evidence>
    <sequence length="384" mass="41622" checksum="B3E98A1B1011F88C" modified="2005-11-22" version="1">MGTAPNKRVMIVAGEASGDLHGSNLVKEALRLDPTLSFFGIGGPHMRAAGVETVVDSSEMAVVGLVEVLAHFGVIYKAYATLKRLITTNPPDLLILIDYPDFNMLVAKVAKRAGVKVLYYISPQVWAWRTGRVKKIARLVDRMAVVFPFEVPFYEKAGVPVSFVGHPLADRVSPSMSRSEALAAFGLDPSRRVVGLFPGSRRGEIARLFPVILESAKLLRDRYPGIQFILPLASSLTDADIAPHLAASGLEVVVARDKVYDVMQVCDAIATVSGTVTLEIALMGVPMVIIYTVSPLTYEVGKRLIRVDHIGICNIVAGERVVPELIQDEATAERIAAEIGRYLDDPVHTEKTRAGLARVREKLGSGGCSERVAGIVLEMLGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T53</accession>
    <name>Q39T53_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0434 protein Gmet_2346</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0434 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513274.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2346"/>
    <dbReference type="EnsemblBacteria" id="ABB32571">
        <property type="protein sequence ID" value="ABB32571"/>
        <property type="gene ID" value="Gmet_2346"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2346"/>
    <dbReference type="eggNOG" id="COG2835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155659_4_2_7"/>
    <dbReference type="OMA" id="ELICHAD"/>
    <dbReference type="OrthoDB" id="1834382at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01187">
        <property type="entry name" value="UPF0434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="62" mass="6753" checksum="39B04D7667CBA21E" modified="2005-11-22" version="1">MALSSELLKILACPQCKGEVVFQDDEVGLVCDSCRLVYPVRDGIPVMLVDEAEKIGEAGKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T64</accession>
    <name>Q39T64_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransf_21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513285.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2335"/>
    <dbReference type="EnsemblBacteria" id="ABB32560">
        <property type="protein sequence ID" value="ABB32560"/>
        <property type="gene ID" value="Gmet_2335"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2335"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089273_0_0_7"/>
    <dbReference type="OMA" id="NAWGEAD"/>
    <dbReference type="OrthoDB" id="1340956at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006342">
        <property type="entry name" value="FkbM_mtfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05050">
        <property type="entry name" value="Methyltransf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01444">
        <property type="entry name" value="fkbM_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransf_21" evidence="1">
        <location>
            <begin position="42"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="233" mass="27255" checksum="EB40FB29BB1E974C" modified="2005-11-22" version="1">MHVRTIVNRIISRYGYEITKIDKFKQYLIEEYNRDDDFCFIQIGANDGVSFDELYSFVTSRKCRGVVVEPLKIYFEKLKQNYSRYPDIIPVNCAVHQNKKKAVLHYVDPAKLDLLPEWVQGIGSLDPNHYKQSGLPSDYIVSEEVECVHLMELIRDNKFEHVNLLQIDVEGYDGEVIKMIDFDVIRPKMIKYEHQSLKKEEQQEITILLESHGYEVFIHGNDSIAIDSSRTMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T89</accession>
    <name>Q39T89_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513310.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2310"/>
    <dbReference type="EnsemblBacteria" id="ABB32535">
        <property type="protein sequence ID" value="ABB32535"/>
        <property type="gene ID" value="Gmet_2310"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2310"/>
    <dbReference type="eggNOG" id="COG3267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024125_3_0_7"/>
    <dbReference type="OMA" id="TNFQLDD"/>
    <dbReference type="OrthoDB" id="947558at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="41"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="267" mass="30127" checksum="18D86779E3580E0A" modified="2005-11-22" version="1">MYREFYGLTEKPFSKTPDPRYLFLSRGHREALARLQYAVEERELALLTGDIGCGKTTISRALMDAVGNDGCFCFIVNPRLSAVEFLRTVARSLGIAEPAAAKDELLRQLTEAVYRLEGEKRCPVIIIDEAQLIPDQEVFDEIRLLTNFQLDDRNLMSVILMGQPELRQILSEPAHEALRQRIAMHYHLQPLSLEETLEYVDFRVEVAGGPQGLFSPDAIRRIYELSGGVPRKINILATNALLVGFGKDSAWIDASLVEELRDEASLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TF5</accession>
    <name>Q39TF5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2242"/>
    <dbReference type="EnsemblBacteria" id="ABB32469">
        <property type="protein sequence ID" value="ABB32469"/>
        <property type="gene ID" value="Gmet_2242"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2242"/>
    <dbReference type="eggNOG" id="COG4564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081845_2_1_7"/>
    <dbReference type="OMA" id="DLYVFVV"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004010">
        <property type="entry name" value="Double_Cache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033480">
        <property type="entry name" value="sCache_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08269">
        <property type="entry name" value="dCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01049">
        <property type="entry name" value="Cache_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Cache_2" evidence="6">
        <location>
            <begin position="19"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Cache_2" evidence="6">
        <location>
            <begin position="161"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="305" mass="34320" checksum="AA48452FA7B2646C" modified="2005-11-22" version="1">MELALRVTNLVEKETIMRKVVLVTALITLLSAHLLFAAEQIKPSTAKPEESYDSKNAKEMLARAVELYNKKKDRSFADFSMQGQFVKGNLYVYVIGTNGKFLASGGSSSVLIGRDVSNMRDAEGKLFFREMIDTAKSQNAGAVEYKWLNRLDGKPEHKHTYFQRIGDRIIAVGFYIPHASDVQAYALLAQAVETLKKDPVSACNAFNDLNSKFIQDDLYVFVVDLKDNIFRAHGATPRLVNTDAMELRNPDGKSIVKEMIGIAKKKGKGTLTYRWRNLLTGKIEVKNTIFRKVDNYLIAVGYYTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TH1</accession>
    <name>Q39TH1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365981.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2226"/>
    <dbReference type="EnsemblBacteria" id="ABB32453">
        <property type="protein sequence ID" value="ABB32453"/>
        <property type="gene ID" value="Gmet_2226"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2226"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_7"/>
    <dbReference type="OMA" id="ITGGRNW"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="261" mass="27686" checksum="C2FB1552455A55FC" modified="2005-11-22" version="1">MGKLAGKVAIITGGSRGMGRATVEVFTKEGARVIIADVLDAEGTALAQEMGDGAIYRHLDVSDERGWGDVARSAIDSFGRIDILVNNAAIFLYALIDETRSEAFRRLLDINVIGPYLGMKTVIPIMKKQRSGSIVNVSSTDGLRGSCGMGAYNASKWGVRGLTKCVAMEVGPFGIRVNSLHPGTVDTPMFNPHGLDRDALNASFGKQFPGVSLSRVGDPSEIARASLFLASDDASYVSGAELAVDGAWTCGVYLQEKPEPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TI5</accession>
    <name>Q39TI5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365968.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2212"/>
    <dbReference type="EnsemblBacteria" id="ABB32439">
        <property type="protein sequence ID" value="ABB32439"/>
        <property type="gene ID" value="Gmet_2212"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2212"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_7"/>
    <dbReference type="OMA" id="GLRFERH"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="262" mass="28204" checksum="030C0FA890B31405" modified="2005-11-22" version="1">MSYEAIMLERNGAVGVLTFNRPEVLNAYNRTLAADIITGFNELVADKSVRAIVLTGAGKAFMAGADINMVNGWTKLGNAAKIKEDLRQLVNPNMIEDCPKPTIAAVNGLAFGMGCELAMACDFRIAAEKAQFGQPEVKLGIIPGAGGSQRLRELVGPTRALEMISTGDPIDAQEAYRIGLVNQVVPRDELMEAVNAFAGRLIDKGAVVLDICKKLVYEGGDLPLRGGIDYEQDQFCKILLTADAQEGTLAFLEKRKPVFNKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TS4</accession>
    <name>Q39TS4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Menaquinol oxidoreductase complex, iron-sulfur cluster-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pcmE</name>
        <name evidence="8" type="ordered locus">Gmet_2121</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513084.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2121"/>
    <dbReference type="EnsemblBacteria" id="ABB32350">
        <property type="protein sequence ID" value="ABB32350"/>
        <property type="gene ID" value="Gmet_2121"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2121"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_1_1_7"/>
    <dbReference type="OMA" id="HRFLCPC"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="64"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="172" mass="18590" checksum="EDA73C07325EFADD" modified="2005-11-22" version="1">MSSENSTGATILPFRTSDDVVDEDRRGFVKKMALTALTVGVGGAAIQSARFFKPNVLYEPSKAFKVGELSKFPIGSRIVIEGRGIEIVRERDGMHAISLVCTHLGCLIKPVENDPDTGYMCPCHGSTFTLTGGVLGGPAPKDLPWYEMYMDNTGALVVDTSKVNHKRTKLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U06</accession>
    <name>Q39U06_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase, IS630 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2039"/>
    <dbReference type="EnsemblBacteria" id="ABB32268">
        <property type="protein sequence ID" value="ABB32268"/>
        <property type="gene ID" value="Gmet_2039"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2039"/>
    <dbReference type="eggNOG" id="COG3335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3415">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041125_0_0_7"/>
    <dbReference type="OMA" id="DRCRMVL"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038717">
        <property type="entry name" value="Tc1-like_DDE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13358">
        <property type="entry name" value="DDE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <feature type="domain" description="DDE_3" evidence="2">
        <location>
            <begin position="172"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="346" mass="40009" checksum="8E07DCA75DEB5956" modified="2005-11-22" version="1">MARTHEQYELKAEDRKSLESILRSPKAAQSTVSRAKVILFTADGKTAEEVAVALGTTPRAVYRWRKRFKDHGLEGLHDRPRSGQPKKLSEKVVKEVLRLSVECIPREATHWSVRLMAKAAGITTWQVRQIWDAADLKPHRLKTFKISYDPQFADKVIDVVGLYMNPPDNAVVLAVDEKTQIQALDRTQPMLPMKPGQIERRTHDYKRHGTTSLYAAFDVLTGEVIGRVTKRHRAKEFLYFLRQIDRSVPKELDLHVILDNSSTHKTAEVNKWLAEHPRFILHFNPTSASWLNAVEGWFAQLERRAIHRGVFTSVKELRDEIQRFNKVHNAHSAKPFKWTQKRQCHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U09</accession>
    <name>Q39U09_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protease, Abi superfamily, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32265.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2036"/>
    <dbReference type="EnsemblBacteria" id="ABB32265">
        <property type="protein sequence ID" value="ABB32265"/>
        <property type="gene ID" value="Gmet_2036"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2036"/>
    <dbReference type="eggNOG" id="COG1266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078735_0_0_7"/>
    <dbReference type="OMA" id="QCILAHA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014346">
        <property type="entry name" value="Prenyl_protease-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03008">
        <property type="entry name" value="pepcterm_CAAX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32265.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="252" mass="28336" checksum="9863FE0AE25BC6FF" modified="2012-10-31" version="2">MTLLGAAVKVTQNYHSSLTQVNRTMHTRTLAHILPFAVFMSFIAIEGLLPWLDKDGVIALQPESPLYLYPLKTMVVGSLLLYFRKHYHEISIKQIVRPSIAISAILAGIIVFMLWIQMDWLLPFQKPAPGYNPNLIPNDIHRIVLIAFRLAGASIVVPVMEEIFWRSYIARMIINQDFESVPVGTFSWASFLGTVLLFGLEHQFIIAGLMAGAIYHALLCRTKSIAACITAHSVTNLLLGIFVLKSGAWRFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UG2</accession>
    <name>Q39UG2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Bifunctional NAD(P)H-hydrate repair enzyme</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Nicotinamide nucleotide repair protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="16">ADP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
                <ecNumber evidence="16">4.2.1.136</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">ADP-dependent NAD(P)HX dehydratase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">NAD(P)H-hydrate epimerase</fullName>
                <ecNumber evidence="16">5.1.99.6</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="18" type="primary">yjeF</name>
        <name evidence="14" type="synonym">nnrD</name>
        <name evidence="15" type="synonym">nnrE</name>
        <name evidence="18" type="ordered locus">Gmet_1883</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 16">Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="14">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="function">
        <text evidence="15">Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15 16">
            <text>(6R)-NADHX = (6S)-NADHX</text>
            <dbReference type="Rhea" id="RHEA:32215"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:64075"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 15 16">
            <text>(6R)-NADPHX = (6S)-NADPHX</text>
            <dbReference type="Rhea" id="RHEA:32227"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:64077"/>
            <dbReference type="EC" id="5.1.99.6"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 14 16">
            <text>(6S)-NADHX + ADP = AMP + H(+) + NADH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32223"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 14 16">
            <text>(6S)-NADPHX + ADP = AMP + H(+) + NADPH + phosphate</text>
            <dbReference type="Rhea" id="RHEA:32235"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.136"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 16">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="15 16">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 16">In the C-terminal section; belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 16">In the N-terminal section; belongs to the NnrE/AIBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.136" evidence="16"/>
    <dbReference type="EC" id="5.1.99.6" evidence="16"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511961.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1883"/>
    <dbReference type="EnsemblBacteria" id="ABB32112">
        <property type="protein sequence ID" value="ABB32112"/>
        <property type="gene ID" value="Gmet_1883"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1883"/>
    <dbReference type="eggNOG" id="COG0062">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0063">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024853_4_1_7"/>
    <dbReference type="OMA" id="HNGGDAL"/>
    <dbReference type="OrthoDB" id="1748633at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052855">
        <property type="term" value="F:ADP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052856">
        <property type="term" value="F:NADHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052857">
        <property type="term" value="F:NADPHX epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01966">
        <property type="entry name" value="NADHX_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030677">
        <property type="entry name" value="Nnr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004443">
        <property type="entry name" value="YjeF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036652">
        <property type="entry name" value="YjeF_N_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03853">
        <property type="entry name" value="YjeF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017184">
        <property type="entry name" value="Nnr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64153">
        <property type="entry name" value="SSF64153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00197">
        <property type="entry name" value="yjeF_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51385">
        <property type="entry name" value="YJEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 15 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12 14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 14 16" id="KW-0521">NADP</keyword>
    <keyword evidence="7 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 16" id="KW-0630">Potassium</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF N-terminal" evidence="17">
        <location>
            <begin position="9"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="59"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="NADPHX" evidence="15">
        <location>
            <begin position="133"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="423"/>
            <end position="427"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR017184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB32112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="514" mass="53305" checksum="4439DDB99EBF7284" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UK2</accession>
    <name>Q39UK2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S18 alanine N-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rimI</name>
        <name evidence="2" type="ordered locus">Gmet_1843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32072.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512003.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1843"/>
    <dbReference type="EnsemblBacteria" id="ABB32072">
        <property type="protein sequence ID" value="ABB32072"/>
        <property type="gene ID" value="Gmet_1843"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1843"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013985_23_2_7"/>
    <dbReference type="OMA" id="GERYLNY"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006474">
        <property type="term" value="P:N-terminal protein amino acid acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006464">
        <property type="entry name" value="AcTrfase_RimI/Ard1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01575">
        <property type="entry name" value="rimI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32072.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="17634" checksum="B1FE60F53518C609" modified="2012-10-31" version="2">MGVTDVHTIHQMTSGDLDEVTAIESVSFPRPWTREHFIDELNSPHSYPLVARTADGIVAGYICPLLVLDEGEILDVAVRLGSRGKGVGGALVRRAITELRAQGARVVCLEVRVSNLPALTLYRQLGFRETGRRKGYYENGEDAILMEYTIDYSEGRADAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UM7</accession>
    <name>Q39UM7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylacetate-coenzyme A ligase</fullName>
            <ecNumber evidence="1">6.2.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylacetyl-CoA ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">paaK-1</name>
        <name evidence="4" type="ordered locus">Gmet_1818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-phenylacetate + ATP + CoA = AMP + diphosphate + phenylacetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:20956"/>
            <dbReference type="ChEBI" id="CHEBI:18401"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57390"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.30"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phenylacetyl-CoA ligase family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.30" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512027.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1818"/>
    <dbReference type="EnsemblBacteria" id="ABB32047">
        <property type="protein sequence ID" value="ABB32047"/>
        <property type="gene ID" value="Gmet_1818"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1818"/>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035301_1_1_7"/>
    <dbReference type="OMA" id="IQNTHGY"/>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="UniPathway" id="UPA00930"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05913">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011880">
        <property type="entry name" value="PA_CoA_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006444">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="2">
        <location>
            <begin position="85"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="3">
        <location>
            <begin position="335"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="433" mass="48801" checksum="C53572F2EDF8BE1F" modified="2005-11-22" version="1">MQIWEPTYECMPREELQQLQLERLQATINRVYKNVTCYRNKFNELGIVPEDIQSLDDLRKLPFTTKEDLRLNYPYGMFAVPLREVVRIHSSSGTTGKPTVVGYTKHDIKVWSNLVARFMTAAGVTLDDVVQVAFGYGLFTGAFGLHYGTETIGASVIPMSSGNTEKQIMIMQDYKTTALVSTPSYAITIADRMEKMGIDPKTLSLKVGLFGGEPWSEAMRKEIESRLFISATDNYGLSEVIGPGIAGDCEHKCGMHIFEDAFIPEIIDPDTGEVLPPGSVGELVLTTLTKEAFPMIRYRTRDITCLDYSPCACGRTMVRMKKTMGRSDDMLIIKGVNVFPSQIEEVLFAIEGCQPHYQIIVDRKGTLDTLEIQIEVIENIFFDEMKRQRAFLEMVEKRIDSRLGVGATVKLVEPNSIPRHEGKAQRVIDRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39US1</accession>
    <name>Q39US1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32003.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1772"/>
    <dbReference type="EnsemblBacteria" id="ABB32003">
        <property type="protein sequence ID" value="ABB32003"/>
        <property type="gene ID" value="Gmet_1772"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1772"/>
    <dbReference type="eggNOG" id="COG1313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062674_0_1_7"/>
    <dbReference type="OMA" id="GGEPTPN"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="PTHR43075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32003.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="313" mass="35032" checksum="0A61356EBB71DA45" modified="2012-10-31" version="2">MRPERDQSRSYTTMRYIDLYQAGELLKRVREAYARLRSCDLCPHDCRVNRLTGETGVCRAGWRPRIASANVHHGEEPPISGSQGSGTIFLSWCSLHCRFCQNFPISQQGNGSDLTTLELAERMLGLQKRGVHNINFVTPTHFLPQILAALWLAIPCGFRLPIVWNSSGYEKIDALQLLDGVVDIYLPDMKYVAEEPAVRFSSAPGYREVNRRAVAEMLRQVGHLVLDDEGIAVRGLIIRHLVLPEGAASSGETLRWIAANLGSETHIALMNQFFPAHRAAETPGIHRKVTDEEYDEAVEALEEAGLENGWVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UU2</accession>
    <name>Q39UU2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ycbK</name>
        <name evidence="1" type="ordered locus">Gmet_1751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513353.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1751"/>
    <dbReference type="DNASU" id="3741427"/>
    <dbReference type="EnsemblBacteria" id="ABB31982">
        <property type="protein sequence ID" value="ABB31982"/>
        <property type="gene ID" value="Gmet_1751"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1751"/>
    <dbReference type="eggNOG" id="COG3108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080400_1_2_7"/>
    <dbReference type="OMA" id="KSYHMKG"/>
    <dbReference type="OrthoDB" id="2028958at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010275">
        <property type="entry name" value="DUF882"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009045">
        <property type="entry name" value="Hedgehog_sig/DD-Pept_Zn-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37425">
        <property type="entry name" value="PTHR37425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05951">
        <property type="entry name" value="Peptidase_M15_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55166">
        <property type="entry name" value="SSF55166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="187" mass="20749" checksum="892F11516883F80D" modified="2005-11-22" version="1">MDFKMLNRRNFLKATLTGALTLMGVGSAFGRFVSTPELLPPGQLSLFNTHTRERIALAFRDAAGNYDLDSLNTLNWILRCHYTNEVTEMDVNTLEFLNLVDKKFGGNNEIHIISAYRSPLYNNLLRENGHGVAQHSLHLAGRAIDISIPGKSIASIREAAVDLHMGGVGFYPNSGFVHIDSGAFRTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UV2</accession>
    <name>Q39UV2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513364.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1741"/>
    <dbReference type="EnsemblBacteria" id="ABB31972">
        <property type="protein sequence ID" value="ABB31972"/>
        <property type="gene ID" value="Gmet_1741"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1741"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868080_0_0_7"/>
    <dbReference type="OMA" id="HILMLGE"/>
    <dbReference type="OrthoDB" id="1031997at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="175"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="317" mass="35690" checksum="65556D83A1C6A823" modified="2005-11-22" version="1">MHAQTKDLTPIKGIRYYYPPDDAVLVFKDEKERIHYGGMPVPLLEDDFARLDGEPSYDEVGRGVYQALRSNPDCILCDKYAALLRDAYPHYLAELASNAIMIDSKDVEVPYLDRKIACLKVLALLEPQNPALPLEIGRVFLDRGMRLSALHLSTVSIYRAEHFLNRAHTLAPDDRNINRYLGEAYYLLGKYDEAVGFWRKATTTDEPEAERLRERIERISAGNVPLIPPVDYLEAIGAAFACNQTGEYEESIAILQDILMDPVFSEEFPIPEIHCVIGKGFTALDMPKYAEAEFRQALVMDPAHEEARALLATIAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UW1</accession>
    <name>Q39UW1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1732</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-ACP thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513371.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1732"/>
    <dbReference type="EnsemblBacteria" id="ABB31963">
        <property type="protein sequence ID" value="ABB31963"/>
        <property type="gene ID" value="Gmet_1732"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1732"/>
    <dbReference type="eggNOG" id="COG3884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045466_2_0_7"/>
    <dbReference type="OMA" id="NKYFCYR"/>
    <dbReference type="OrthoDB" id="1989068at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:acyl-[acyl-carrier-protein] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002864">
        <property type="entry name" value="Acyl-ACP_thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045023">
        <property type="entry name" value="FATA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31727">
        <property type="entry name" value="PTHR31727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01643">
        <property type="entry name" value="Acyl-ACP_TE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0150">Chloroplast</keyword>
    <keyword evidence="4" id="KW-0934">Plastid</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="247" mass="28219" checksum="8BDF6599C8C834FD" modified="2005-11-22" version="1">MKTENSIFETSFTIRSFDVDPHGFVSPVTLLGYLQEAASEHMTLLGGTVRSLMAEGLTWVLSRVHLSIERYPRVRNEMTVRTWPSLREGRFTCREFELLDRTGAVMARATTSWAVIDFKTRRAVRVDRHPPYPLTPRRAIDDDFALLPALKGSQAEERFRVRRSDLDLNHHVNHMVYAGWALDAVPDEVAERHKLVSLEIGYRAEALAGEEVTVCCACAEDDNGILVIHRIASADCRELTRLRTRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V07</accession>
    <name>Q39V07_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Undecaprenyl-phosphate glycosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514168.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1686"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31917">
        <property type="protein sequence ID" value="ABB31917"/>
        <property type="gene ID" value="Gmet_1686"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1686"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_7_4_7"/>
    <dbReference type="OMA" id="TEYSMSK"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="220" mass="24282" checksum="0B8D1D343782B0FC" modified="2005-11-22" version="1">MGICVVIPAFNAALTIEAVVRETLEQGLPLVVVDDGSEDGTADCVRGLPVNLVSHGRNRGKGAALKTGFAWALEYGFSGVITLDSDGQHDPTAITLLAETAKNDGWDILVASRFAQFNQMAGLRRHWNRFGAWCMKKRTGFQIDDSQSGFRYYSARLLRMVSLGKDGYDLEMEILMKAWQAGCTIGSVPVPARVADGRATSHFRPVRDTWNICMTFLRYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V08</accession>
    <name>Q39V08_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase and DUF3473 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514169.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1685"/>
    <dbReference type="EnsemblBacteria" id="ABB31916">
        <property type="protein sequence ID" value="ABB31916"/>
        <property type="gene ID" value="Gmet_1685"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1685"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066872_0_0_7"/>
    <dbReference type="OMA" id="GFRAPQW"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10941">
        <property type="entry name" value="CE4_PuuE_HpPgdA_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045235">
        <property type="entry name" value="CE4_PuuE_HpPgdA-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022560">
        <property type="entry name" value="DUF3473"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11959">
        <property type="entry name" value="DUF3473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="17"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="273" mass="30329" checksum="0472BC5D43A3EEBF" modified="2005-11-22" version="1">MNNALTIDVEEWFHVCGVAGYGYGTHPSHVLRNVDRLLECFAAVDVTATFFVLGSVAEALPSLVPAIAAAGHEVASHGFSHTLITALSPAAFRDELRRTNDILSIQSGKRPIGFRAPQWSLSRTVTPWAFEILHDEGFRYDSSCNPLPFVGDRSGSRVPYKIGMAGKSLWEIPPMVTPSMLGNLPTGGGWGFRFFPPRMIERTVQRLNEEGQSAVFYLHPREIDPSGPRLPLSLFRQFVAYGPRTDALQRLVPLMKRFRFTSLGNLVDQWESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V42</accession>
    <name>Q39V42_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux pump, RND family, membrane fusion lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1651</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511412.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1651"/>
    <dbReference type="EnsemblBacteria" id="ABB31882">
        <property type="protein sequence ID" value="ABB31882"/>
        <property type="gene ID" value="Gmet_1651"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1651"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_2_0_7"/>
    <dbReference type="OMA" id="GQLMAIH"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="67"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="407" mass="43719" checksum="DD623D872CCAEDB8" modified="2005-11-22" version="1">MNLSLSPRDPSRSGILSRRVRRLVVQGAAYSLIVTLAACAKKEQKPAAKPPVPVAIATVERKTVPVQIKAIGNVEPYATVAVKAQVNGEVLKVHFTEGQDVKRGDLLFAIDPRTYQAAVKKAEANLSRNLVQARNARQDAERYAQLVKEGIVTSEQYEQYRTRAEAFAADVSADRAAVENAKVELSYCFIRSPLTGRTGNLAVHAGNIVKANENPPLVTINQITPVYVAFSIPEKDLAEVKRRMAAGKLAVEATIPNDAGPAEQGMISFLDNTVDVATGTIKLKGTFENRARRLWPGQFANVVVTLAARPNAIVVPAQAIQTGQSGPYVFVVKADSSVEIRPVTPGIAYEGVTIIEQGLAPGERVVTDGQMRLTPKARVTEKPGPGTRDQGPANPRQASGQPKGQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V52</accession>
    <name>Q39V52_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">GAF sensor methyl-accepting chemotaxis sensory transducer, class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mcp40H-1</name>
        <name evidence="4" type="ordered locus">Gmet_1641</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511423.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1641"/>
    <dbReference type="EnsemblBacteria" id="ABB31872">
        <property type="protein sequence ID" value="ABB31872"/>
        <property type="gene ID" value="Gmet_1641"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1641"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_393690_0_0_7"/>
    <dbReference type="OMA" id="DQITHNM"/>
    <dbReference type="OrthoDB" id="166804at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="3">
        <location>
            <begin position="339"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="663" mass="72752" checksum="9C177CDC5076E1D1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VA0</accession>
    <name>Q39VA0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc-dependent peptidase, M16 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1592</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511473.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1592"/>
    <dbReference type="EnsemblBacteria" id="ABB31824">
        <property type="protein sequence ID" value="ABB31824"/>
        <property type="gene ID" value="Gmet_1592"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1592"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_3_3_7"/>
    <dbReference type="OMA" id="IDVVCDM"/>
    <dbReference type="OrthoDB" id="1188251at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M16" evidence="4">
        <location>
            <begin position="12"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="5">
        <location>
            <begin position="165"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="418" mass="46622" checksum="42D204A9CCBF211E" modified="2005-11-22" version="1">MVSKTILDNGVRVISEYMPHAHSVSIGIWVANGSRHERREHNGVAHFIEHLLFKGTVRRSALDIAREIDSVGGVLNAFTSREYVCYYAKVLDKNLPQAVDLLTDIFLNSTFDPEEIEKERKVVLQEISMLEDSPDDYVHDLFHRSFWRGHPLGMSILGSAESVSNLSRDAIVAHRDAMYRSEDIIVAVAGNVRHDELLKLISGSFDSVPEGTGRNCCHLPVYDQKLEIVEKDLEQLHICLGTKSLPHNHPRRFEAYLMNTILGGSMSSRLFQEIREHLGLAYTVYSYVVSHTDAGSLVVYAGTSPEKLSDVLEITCSELRRLKFEPVPATELEAAREQLKGNILLSLESSDNRMTKLAKNEIYFGRYLSLAELTGGFDSATADGIAELANDFFSGDYVTLALTGKISGQIPDLSHLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VJ1</accession>
    <name>Q39VJ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365836.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1499"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31733">
        <property type="protein sequence ID" value="ABB31733"/>
        <property type="gene ID" value="Gmet_1499"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1499"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_694141_0_0_7"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="2">
        <location>
            <begin position="181"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="363" mass="39988" checksum="7D05BE5C11737CDB" modified="2005-11-22" version="1">MGMEPDKKVCIIGPSPDSPYQGGVATHISTLKTLACFKDAEVIDPGSIHSNNKTGIVSIFRSLTGLKQRILLGRFTHVFVNTSIYTGSIIKLLLILAILPNADNTKIHVFYHGGRFQSLPAWLSVLLSTLCLRLMHKVRMHHFLSKIQQEGFVPVCKGCSVGLFANYAQGDDIWLRHLKSQNAPLKLLFVGRLVKEKGIFEALEAFNRLHGADGQVELTVAGDGPAYPELSTMCKYISDGALRFLGHVSGETLEQAYREADLLVIPSYHEAFPYAAIEAMRAGLPMISTSSGALEMLVEDGVTGFKIPPRDVSALEKAIRTILENRELLKPMSDNCYEYFKAHLSKSAAEQYYSRLLGTCTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VK5</accession>
    <name>Q39VK5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1485"/>
    <dbReference type="EnsemblBacteria" id="ABB31719">
        <property type="protein sequence ID" value="ABB31719"/>
        <property type="gene ID" value="Gmet_1485"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1485"/>
    <dbReference type="HOGENOM" id="CLU_2584744_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="80" mass="8917" checksum="2BCA2AAD6C1032CB" modified="2005-11-22" version="1">MNVLCSRPVAGAYAALAFVQFSDPMHQFQLALRKGGAVPFQIEPVHHPFALVIGYSGRGPRFQFFPFILPSDESYEIAFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VQ0</accession>
    <name>Q39VQ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511629.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1440"/>
    <dbReference type="EnsemblBacteria" id="ABB31674">
        <property type="protein sequence ID" value="ABB31674"/>
        <property type="gene ID" value="Gmet_1440"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1440"/>
    <dbReference type="eggNOG" id="ENOG5033DFP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_192878_0_0_7"/>
    <dbReference type="OMA" id="CRKHAIT"/>
    <dbReference type="OrthoDB" id="2065537at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="84" mass="9743" checksum="008BE48737E9B9E3" modified="2005-11-22" version="1">MLQRVQEQIRVGAVFGPGPSIHPVWFDWRQQKHAIEKVTYRWRHIAGNALLLHFAVTDGTALYELIYNSREQLWTLEAADAEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VT3</accession>
    <name>Q39VT3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511660.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1407"/>
    <dbReference type="EnsemblBacteria" id="ABB31641">
        <property type="protein sequence ID" value="ABB31641"/>
        <property type="gene ID" value="Gmet_1407"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1407"/>
    <dbReference type="eggNOG" id="COG1134">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="AVDAEFM"/>
    <dbReference type="OrthoDB" id="887953at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03220">
        <property type="entry name" value="ABC_KpsT_Wzt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015860">
        <property type="entry name" value="ABC_transpr_TagH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="34"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="66"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="233" mass="25674" checksum="A9FDA3BA9D62C49E" modified="2005-11-22" version="1">MSSDALLIFSDVWKKYSRAEAFHRSIREDLSCFLRSDLNLRNKDEFWALKGANFSLHPGECVGLTGPNGAGKSTILKLVARVTSPSSGDIRQTAKVAPLIEVGAGFHPDLTGRQNIYMNGTIIGLSLSDIRKQMTSIIDFSELAEFIDTPVKKYSSGMYLKLAVAIAFHSPAKILLVDEILSVADELFRNKCLERIRRFCEAGGGVVLVSHDQRILNSVTDRTIRLVSGEIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VT5</accession>
    <name>Q39VT5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphoglycosyl-diphosphate--polyprenyl-phosphate phosphoglycosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1405"/>
    <dbReference type="EnsemblBacteria" id="ABB31639">
        <property type="protein sequence ID" value="ABB31639"/>
        <property type="gene ID" value="Gmet_1405"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1405"/>
    <dbReference type="eggNOG" id="COG0382">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029423_0_1_7"/>
    <dbReference type="OMA" id="RWFLITT"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PTHR11048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="286" mass="31770" checksum="59248EB53D2FD16E" modified="2005-11-22" version="1">MIRRADLLAFLQLARPHQWLKNIILFFPPFLGGVLLLPGEWQKGVAPFVAFSLTSSATYVFNDLRDRDNDRVHPRKKHRPLAAGLISIPAAICFALVMLIGSFAIGYTVSFVFCGWLLAYLGVSFAYSLVLKDQPVFDIFCIASGFVFRVFAGGAAFGVKVSDWLFLSVLLLAVFLSCGKRLSEKKLLGSASCDHRKVLETYPAGALEGFMYISGAAVLVTYTLYAITQHRLIYTVPLCCFGLFRYLLIVERGQSGDPTDMLMKDPVLFLTGLTWTLFVGWGIYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W13</accession>
    <name>Q39W13_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Undecaprenyl-diphospho-oligosaccharide flippase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1326</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514701.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1326"/>
    <dbReference type="EnsemblBacteria" id="ABB31561">
        <property type="protein sequence ID" value="ABB31561"/>
        <property type="gene ID" value="Gmet_1326"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1326"/>
    <dbReference type="eggNOG" id="COG2244">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042154_0_0_7"/>
    <dbReference type="OMA" id="KFTIMAL"/>
    <dbReference type="OrthoDB" id="1661399at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009246">
        <property type="term" value="P:enterobacterial common antigen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13125">
        <property type="entry name" value="MATE_like_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029303">
        <property type="entry name" value="Polysacc_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044550">
        <property type="entry name" value="WzxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14667">
        <property type="entry name" value="Polysacc_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_C" evidence="7">
        <location>
            <begin position="119"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="422" mass="47006" checksum="D2347AA7D429E9A0" modified="2005-11-22" version="1">MNLIKTSLLNGIAVVIRLFTSIGLNKVLALYVGPAGYAVIGQFQNAMGMLTSFASAGITTGVTKYTAEYFDDEEQQHTVWRTAGTIVFCGSLFASLGIALFHRSLARMFLKDEAYAGVFLWLAATLILMVFNGLLLAILNGKKDIRRYVTVNITGSLVSLIVTGILAKVWGLYGALVALAINQSIVFIVTFAMCQRAAWFRVAHIIGPIDLIAARNLGKFMLMALTTAAVGPTSQIIVRDHLATKFGWTSAGHWQAVTKISDIYLMLITTTLSVYYLPKLSEIRDITEIKKEILRGYKLILPLTVSGASIIYLLRDWIVEILFTKDFYPMTELFAWQLSGDVVKICSWLLAYVMLGRALVRTFIFTEILFGTTFIGFTFVFTKYVGLKGATVGYFINYVVYWITMIYLIPKFINGRRHISAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W17</accession>
    <name>Q39W17_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Toxin, HicA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1322</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HicA mRNA interferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514704.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1322"/>
    <dbReference type="EnsemblBacteria" id="ABB31557">
        <property type="protein sequence ID" value="ABB31557"/>
        <property type="gene ID" value="Gmet_1322"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1322"/>
    <dbReference type="eggNOG" id="COG1724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_6_0_7"/>
    <dbReference type="OrthoDB" id="2053618at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038570">
        <property type="entry name" value="HicA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="76" mass="8758" checksum="F13DE641C3E3739E" modified="2005-11-22" version="1">MGRLSGFRYREIIKRLKAFGFVFDRQAAGSHEIWYNPDKDKYTTIPNHAGDMPEGTLRAILKQAEIDPEDFLKTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W43</accession>
    <name>Q39W43_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Oligoendopeptidase F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pepF</name>
        <name evidence="9" type="ordered locus">Gmet_1295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31531.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512071.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1295"/>
    <dbReference type="EnsemblBacteria" id="ABB31531">
        <property type="protein sequence ID" value="ABB31531"/>
        <property type="gene ID" value="Gmet_1295"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1295"/>
    <dbReference type="eggNOG" id="COG1164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021290_3_0_7"/>
    <dbReference type="OMA" id="YRQTMFA"/>
    <dbReference type="OrthoDB" id="1935578at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013647">
        <property type="entry name" value="OligopepF_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042088">
        <property type="entry name" value="OligoPept_F_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011977">
        <property type="entry name" value="Pept_M3B_clade3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PTHR11804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08439">
        <property type="entry name" value="Peptidase_M3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02290">
        <property type="entry name" value="M3_fam_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase_M3_N" evidence="8">
        <location>
            <begin position="111"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M3" evidence="7">
        <location>
            <begin position="198"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31531.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="593" mass="67297" checksum="AF9EF3FAB1876EFA" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W87</accession>
    <name>EFTS_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor Ts</fullName>
            <shortName evidence="1">EF-Ts</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tsf</name>
        <name type="ordered locus">Gmet_1251</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-Ts family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365792.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W87"/>
    <dbReference type="SMR" id="Q39W87"/>
    <dbReference type="STRING" id="269799.Gmet_1251"/>
    <dbReference type="EnsemblBacteria" id="ABB31487">
        <property type="protein sequence ID" value="ABB31487"/>
        <property type="gene ID" value="Gmet_1251"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1251"/>
    <dbReference type="eggNOG" id="COG0264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047155_1_1_7"/>
    <dbReference type="OMA" id="DAGMMDC"/>
    <dbReference type="OrthoDB" id="1405357at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00050">
        <property type="entry name" value="EF_Ts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036402">
        <property type="entry name" value="EF-Ts_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001816">
        <property type="entry name" value="Transl_elong_EFTs/EF1B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014039">
        <property type="entry name" value="Transl_elong_EFTs/EF1B_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018101">
        <property type="entry name" value="Transl_elong_Ts_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11741">
        <property type="entry name" value="PTHR11741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00889">
        <property type="entry name" value="EF_TS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="SSF46934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54713">
        <property type="entry name" value="SSF54713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00116">
        <property type="entry name" value="tsf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01126">
        <property type="entry name" value="EF_TS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01127">
        <property type="entry name" value="EF_TS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000241485" description="Elongation factor Ts">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in Mg(2+) ion dislocation from EF-Tu" evidence="1">
        <location>
            <begin position="81"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00050"/>
        </source>
    </evidence>
    <sequence length="216" mass="23528" checksum="AFED0AE46AF6FE6E" modified="2005-11-22" version="1">MSITAAQVNELRKATGAGLMDCKKALTETGGDHEKAIDYLRKKGLAAASKKAGRVASEGAVGSYIHAGGKIGVLVEVNCETDFVARNENFQAFVKDIAMHIAAAAPQYVRREEVTADVVEREKEIYRAKARETGKPENIIEKIIEGQVNKFYADICLLEQQYVKDSDKTVQQFLNETIASIGENISIRRFVRYALGEGLAKKETDFAAEVAAAAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WT9</accession>
    <name>Q39WT9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aldehyde:ferredoxin oxidoreductase, tungsten-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aorA</name>
        <name evidence="9" type="ordered locus">Gmet_1045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513218.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1045"/>
    <dbReference type="EnsemblBacteria" id="ABB31285">
        <property type="protein sequence ID" value="ABB31285"/>
        <property type="gene ID" value="Gmet_1045"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1045"/>
    <dbReference type="eggNOG" id="COG2414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_7"/>
    <dbReference type="OMA" id="AHHKDAW"/>
    <dbReference type="OrthoDB" id="332680at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="8">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="576" mass="60656" checksum="BAF8CED753C467B6" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WW7</accession>
    <name>Q39WW7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513186.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1015"/>
    <dbReference type="EnsemblBacteria" id="ABB31257">
        <property type="protein sequence ID" value="ABB31257"/>
        <property type="gene ID" value="Gmet_1015"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1015"/>
    <dbReference type="eggNOG" id="ENOG5032XSR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_656823_0_0_7"/>
    <dbReference type="OMA" id="ENETAHK"/>
    <dbReference type="OrthoDB" id="1913214at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021236">
        <property type="entry name" value="Uncharacterised_YfdX"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10938">
        <property type="entry name" value="YfdX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005694614" evidence="1">
        <location>
            <begin position="27"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="418" mass="47031" checksum="2E63B4B6AA086274" modified="2005-11-22" version="1">MKRSAFVLLAVLAGYLPFCPAAPAEAVDTPSAGLYRSITQREEGVISRTAVMALRSIVQARADIHQKMLEKARHDLNEATLLMETIRSDLSTAVVRNRIWIARTHLEYETAQRVMEDLPPIFSALRDIEEYFPTDKAKRHIDNAKRYLEKGEKKGAERELHLADNELVVVEVELPIAKAETYVTRAKEYLARNDVTKADEALKVAEEKAQAVPVGMESALQRAQSSFWRASRSYAAGKPAEARTYIEQARMYLEKAAKTGNVKGKEEVGTLSRSVTELEQKLDKGDNTAESALASAWNKSRALAERESEYLAARWEEAETTLSVDDDLIEAKLHVSYGETYQVITRESAKAAEELDRAAAYLDKAMKNSLLDQATIKRIGAIRKEVTSLREAPEQSDEAWKDRYDQIKDEINKLLRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WY1</accession>
    <name>Q39WY1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514694.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1001"/>
    <dbReference type="EnsemblBacteria" id="ABB31243">
        <property type="protein sequence ID" value="ABB31243"/>
        <property type="gene ID" value="Gmet_1001"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1001"/>
    <dbReference type="HOGENOM" id="CLU_1178862_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="235" mass="26673" checksum="6C099C4F0D2552E1" modified="2005-11-22" version="1">MDYKDIIDIVCALVTTSATVILAFLTSRYVKLTNAIVEESKSSRDPLVYVDIEPSHHYVKLVVGNAGMTAAHDVKVDIQDEVKWERLKQHVFGFQPRERLQSGIPYLAPHRVLQYELGLPKWQELKEKDGILKITIKFRNDRNVLTEKLCQINLSQYLAISMDSFSNSNKDIVRAINDLERSSRQKDTSLKSALHHFTQKKCPMCGEGISLSAKKCPKCLEFIEAAVPAQETIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WZ1</accession>
    <name>Q39WZ1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Nitrogen fixation protein NifU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nifU</name>
        <name evidence="8" type="ordered locus">Gmet_0991</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in the formation or repair of [Fe-S] clusters present in iron-sulfur proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the NifU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365755.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0991"/>
    <dbReference type="EnsemblBacteria" id="ABB31233">
        <property type="protein sequence ID" value="ABB31233"/>
        <property type="gene ID" value="Gmet_0991"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0991"/>
    <dbReference type="eggNOG" id="COG0694">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0822">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079283_0_0_7"/>
    <dbReference type="OMA" id="IRPMLMM"/>
    <dbReference type="OrthoDB" id="1793654at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016217">
        <property type="entry name" value="N_fixation_NifU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010238">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001075">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="PTHR10093"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01106">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000375">
        <property type="entry name" value="NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="SSF117916"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02000">
        <property type="entry name" value="NifU_proper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NifU_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Fer2_BFD" evidence="7">
        <location>
            <begin position="142"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="NifU" evidence="5">
        <location>
            <begin position="217"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="286" mass="30963" checksum="FB3C1044F17D6C52" modified="2005-11-22" version="1">MWDYTEKVREHFLNPRNVGDIPDADAVGEVGSLACGDALKLYIKLDDAKERIVDAKFQTFGCASAIASSSALTEIIKGKTLDEALATTNQEIADFLGGLPEEKMHCSVMGQEALEVAIAKYRGGPVPTHHDHGHEEVEPGEIVCKCFGLTDTFLKKVIAANKLTTAEQVTHFTKAGGACGGCIPKIKELISEVLGAQPTEERKKPEKLTNLRKMQLIQETLEKEIRPLLWADGGDLELVDISGSEVQIAFRKACAGCASSGNTAKFVELKLRDLVADDIVVQEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X53</accession>
    <name>Q39X53_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidoglycan glycosyltransferase MrdB</fullName>
            <shortName evidence="6">PGT</shortName>
            <ecNumber evidence="6">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cell elongation protein RodA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Cell wall polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Peptidoglycan polymerase</fullName>
            <shortName evidence="6">PG polymerase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">rodA</name>
        <name evidence="6" type="synonym">mrdB</name>
        <name evidence="7" type="ordered locus">Gmet_0929</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Peptidoglycan polymerase that is essential for cell wall elongation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the SEDS family. MrdB/RodA subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513959.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0929"/>
    <dbReference type="EnsemblBacteria" id="ABB31171">
        <property type="protein sequence ID" value="ABB31171"/>
        <property type="gene ID" value="Gmet_0929"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0929"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_2_2_7"/>
    <dbReference type="OMA" id="HDYQKKR"/>
    <dbReference type="OrthoDB" id="1133883at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02079">
        <property type="entry name" value="PGT_RodA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011923">
        <property type="entry name" value="RodA/MrdB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474:SF1">
        <property type="entry name" value="PTHR30474:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02210">
        <property type="entry name" value="rodA_shape"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3 6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="6" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="366" mass="40830" checksum="1F123E9952F57B56" modified="2005-11-22" version="1">MIDRRLFTNFDWTLLVLVFLISAMGIVNIYSASASYTLVGAPYYLKQFYWIVAGMFLVVLACSVDYHLLEDVTYWFYGLLCVVLVAVLLMGKTSMGATRWLHLGFFSIQPSEPMKVVMIMTLARFLSRYPAVDGLTVRDLVYPLLFVGGPAILIMKQPDLGTAIVIILIACSMIAYVGVRLATLVACLAATVPAIYLGWRYYLRDYQKNRILNFLNPERDPLGSGYHIIQSKIAVGSGGIFGKGFTHGTQTQLRFLPEQHTDFAFSVFGEEWGFIGCLTLLLLYLFLIFWGLHIAGRCNDRFGSLMAVGVTAMLFWHTIINIGMVIGVFPVVGVPLPLFSYGGTSMITSMIGVGVLLNISMRRFMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X97</accession>
    <name>Q39X97_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-4-deoxy-4-formamido-L-arabinose--undecaprenyl-phosphate 4-deoxy-4-formamido-L-arabinosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arnC</name>
        <name evidence="3" type="ordered locus">Gmet_0885</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513032.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0885"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31127">
        <property type="protein sequence ID" value="ABB31127"/>
        <property type="gene ID" value="Gmet_0885"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0885"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_0_7"/>
    <dbReference type="OMA" id="NKNYGQT"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="310" mass="35177" checksum="EBE313FDA94A6959" modified="2005-11-22" version="1">MSKPYISIIIPVYNEEPNLQKLLARLYPVMTALGKPFEIIFTDDGSRDRSLEILREMAQSHPEVKVIEFNGNFGQHMAIMAAFEMSAGEIVVTLDADLQNPPEEIPKLVAEMEKGHDVVGSVRQKRQDTFFRRAASRIVNITTNKMTGMQMSDYGCMLRAYNRTVIDNLNRCQEMTTFIPALAQTFASNPSEVPVSHAERAEGESKYSLYRLIRLNFDLMTGFSVVPLQLFALLGILTSVASVLFALFLLVRRFLIGSEVEGVFTLFAILFFFVGIIIFGIGLVGEYVGRIYQEVRRRPRYVVRRTYGFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XB9</accession>
    <name>Q39XB9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Prephenate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tyrA</name>
        <name evidence="2" type="ordered locus">Gmet_0863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513009.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0863"/>
    <dbReference type="EnsemblBacteria" id="ABB31105">
        <property type="protein sequence ID" value="ABB31105"/>
        <property type="gene ID" value="Gmet_0863"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0863"/>
    <dbReference type="eggNOG" id="COG0287">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055968_0_1_7"/>
    <dbReference type="OMA" id="MWRDICL"/>
    <dbReference type="OrthoDB" id="533829at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008977">
        <property type="term" value="F:prephenate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004665">
        <property type="term" value="F:prephenate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003099">
        <property type="entry name" value="Prephen_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02153">
        <property type="entry name" value="PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51176">
        <property type="entry name" value="PDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate/arogenate dehydrogenase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="286" mass="30774" checksum="C99343AD1B65D2CC" modified="2005-11-22" version="1">MPFIHRLAIIGVGLIGGSLARILREKGAVGEIVGIGRGEANLRKAVELGVIDRYSLDSVAGVEGADVVFLATPVCSIPSITAEIAPHLAPGCVVTDGGSVKEEIVSACEPLMPNGIHFVGGHPIAGTEHSGVEASFSSLYVGKRCIVTPTSRTSQDALAKVVRMWEVAGSEVVIMDTEKHDRVLAAISHLPHMVAYALVNAVEGYDRFEESILRYSAGGFRDFTRIASSDPAMWRDIALMNREAVIEMMDHFAAYFARLRELVAAADAPGLERFFRESKESRDAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XC0</accession>
    <name>Q39XC0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional chorismate mutase/prephenate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.51</ecNumber>
            <ecNumber evidence="7">5.4.99.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Chorismate mutase-prephenate dehydratase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">p-protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="primary">pheA</name>
        <name evidence="23" type="ordered locus">Gmet_0862</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="23 24" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate = prephenate</text>
            <dbReference type="Rhea" id="RHEA:13897"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="5.4.99.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; prephenate biosynthesis; prephenate from chorismate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="8"/>
    <dbReference type="EC" id="5.4.99.5" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31104.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513008.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0862"/>
    <dbReference type="EnsemblBacteria" id="ABB31104">
        <property type="protein sequence ID" value="ABB31104"/>
        <property type="gene ID" value="Gmet_0862"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0862"/>
    <dbReference type="eggNOG" id="COG0077">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035008_0_1_7"/>
    <dbReference type="OMA" id="PLMIYRE"/>
    <dbReference type="OrthoDB" id="1280729at2"/>
    <dbReference type="UniPathway" id="UPA00120">
        <property type="reaction ID" value="UER00203"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004106">
        <property type="term" value="F:chorismate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046417">
        <property type="term" value="P:chorismate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.59.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036263">
        <property type="entry name" value="Chorismate_II_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036979">
        <property type="entry name" value="CM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002701">
        <property type="entry name" value="CM_II_prokaryot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010957">
        <property type="entry name" value="G/b/e-P-prot_chorismate_mutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018528">
        <property type="entry name" value="Preph_deHydtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01817">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00830">
        <property type="entry name" value="CM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48600">
        <property type="entry name" value="SSF48600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01807">
        <property type="entry name" value="CM_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51168">
        <property type="entry name" value="CHORISMATE_MUT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00857">
        <property type="entry name" value="PREPHENATE_DEHYDR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00858">
        <property type="entry name" value="PREPHENATE_DEHYDR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chorismate mutase" evidence="20">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Prephenate dehydratase" evidence="21">
        <location>
            <begin position="88"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="22">
        <location>
            <begin position="275"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="site" description="Essential for prephenate dehydratase activity" evidence="19">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00014401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR001500-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="ABB31104.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="355" mass="39599" checksum="91E46D45DEE70713" modified="2012-10-31" version="2">MKTLQELRRDIDAIDDQILDLLNSRSRLAIEVGKVKAGENRDFHVPSREREIYERLAAGNSGPFPNEAVRSVFREIISASLALESPMKVAFLGPKATFTHLASLQHFGLSAELVPQKSIPAVFEEVSKGRSLYGVVPVENSTEGMVSHTLDMFMESDLKINAEILLEVSHDLLSRTGRLEDVKKVYSHPQAIAQCRNWLDENLSGVPVVDVASTALAAQIVGEDYTAAAIASEFAAALYDLKVVRHRIEDQVNNFTRFLVVGRKMADRCGDDKTSLMFSVKDEPGILHRMLEPFAKRGVNLSKIESRPLKKKAWEYIFFLDLAGHISDPVVSDAVQELKNYCQFVKILGSYPRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XQ0</accession>
    <name>Q39XQ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514449.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0732"/>
    <dbReference type="EnsemblBacteria" id="ABB30974">
        <property type="protein sequence ID" value="ABB30974"/>
        <property type="gene ID" value="Gmet_0732"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0732"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_3_7"/>
    <dbReference type="OMA" id="WRMGWII"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="35"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="397" mass="44231" checksum="EEC9597AD368FABD" modified="2005-11-22" version="1">MPIATKIAGHISKSSWIRKMFEEGERLRQVHGAENVYDFTLGNPDTEPPREFQEEFARLATNPIPGMHRYMNNAGYQETRAAVAEVLAEASGLPVEAGHVVMTCGAGGALNVVLKTILNPGEEVIILTPYFVEYKFYIDNHGGVPKEVWTNRETFQLNIPAIEAAITNKTRAVIICSPNNPTGVIYPEESLKELGEMLARAERRYDRQIYVISDEPYARIAFDGKHVPNIFRYVESSVIVTSHSKDLALPGERIGYLAVNPSARGVEQFVEGAVFSNRVLGYVNAPALMQRLVTKLQRASVDIGEYQSKRDLLYDRLTAMGFEMVRPDGAFYLFPKSPLTDDVEFVKMAQKHRILLVPGAGFGAPGFFRIAYCVDRGMIERSLPAWQQLARETGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XR3</accession>
    <name>Q39XR3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0719</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514624.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0719"/>
    <dbReference type="EnsemblBacteria" id="ABB30961">
        <property type="protein sequence ID" value="ABB30961"/>
        <property type="gene ID" value="Gmet_0719"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0719"/>
    <dbReference type="HOGENOM" id="CLU_449607_0_0_7"/>
    <dbReference type="OMA" id="ACADVEL"/>
    <dbReference type="OrthoDB" id="1446163at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223425" evidence="1">
        <location>
            <begin position="25"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="654" mass="68240" checksum="0E67F96A4A859D84" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XT0</accession>
    <name>Q39XT0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0702</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514093.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0702"/>
    <dbReference type="EnsemblBacteria" id="ABB30944">
        <property type="protein sequence ID" value="ABB30944"/>
        <property type="gene ID" value="Gmet_0702"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0702"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="NEEGLCR"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="145"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="460" mass="51691" checksum="BB5B7C66F6381151" modified="2005-11-22" version="1">MSENKRIMLIDNEEGLCRMMEAVLLDSGYGVKGYTRSFEAVEEFRPGDWDLVVSDIKMPGMDGLEVLQRIKAKEPAIPVIMITAYATVEMSIQALRRGAYDMLTKPFEPEELLYRVKNALKHTELLEENRELREKLVGKFRFDNIIGASDGLKGVLEKVEKIAIRDTSVLITGESGTGKELIAQAIHYNSVRKEKKFVAINCGALPETLLESELFGYRKGAFTGAKENRQGLLEAADGGTLFLDEVGNLPMNVQKTLLRFLQEQEFLRIGDTTPTKVDVRIISATNADLREGVKSGAFREDLYYRLNVVNLHLPPLRERKGDIPLLAAHFIAQQNKKFDTAIKGLSPDSLEAAVGYAWPGNIRQLRNVIEACTAMESGEYITLSVLSQFIELPEPRDEPAVEAEGEEGAYAQALSRFEMDYIRGLLRKNRGNVEAAAREAGMNMATIYRKMKKYNLRREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y72</accession>
    <name>Q39Y72_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512256.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0559"/>
    <dbReference type="EnsemblBacteria" id="ABB30802">
        <property type="protein sequence ID" value="ABB30802"/>
        <property type="gene ID" value="Gmet_0559"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0559"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_334583_0_0_7"/>
    <dbReference type="OMA" id="AYRGLHF"/>
    <dbReference type="OrthoDB" id="75364at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007742">
        <property type="entry name" value="NosD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05048">
        <property type="entry name" value="NosD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223454" evidence="1">
        <location>
            <begin position="31"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="317"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="3">
        <location>
            <begin position="412"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="NosD" evidence="2">
        <location>
            <begin position="661"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="832" mass="88491" checksum="FDA84C5164CC34BE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YA0</accession>
    <name>Q39YA0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese homology domain pair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512227.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0531"/>
    <dbReference type="EnsemblBacteria" id="ABB30774">
        <property type="protein sequence ID" value="ABB30774"/>
        <property type="gene ID" value="Gmet_0531"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0531"/>
    <dbReference type="eggNOG" id="COG2897">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_620750_0_0_7"/>
    <dbReference type="OMA" id="RYWGFPK"/>
    <dbReference type="OrthoDB" id="920668at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001307">
        <property type="entry name" value="Thiosulphate_STrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="PTHR11364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00380">
        <property type="entry name" value="RHODANESE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="104"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="320"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="445" mass="46810" checksum="E390040F266F8F9E" modified="2005-11-22" version="1">MAKQAWRKGRIILSGMLGVVALAMLTLWGCGGGGGKSYDTPSLNGPAPVATKTATPLVDAVTLKGWLDAGLVNKAAGSERVVILEFSGSYVDTSVTPNVTKLRYNDGHIPGAIRVDLTAELMANRVEGPAEFAQMVASGAQMDALIKRCGIDENTTIVFTTSEAEMNSNTLWNITRPYTTFRYWGFPKERLKVLDGGNKAWVAAAYPMTTVAPTITASTYNVTPLNTNRVKANLRASLSEMIAAVNAGTGLIIDGRTDGVPGSTTDLVESSKYVVFEGRMTGGSGYSHVNLVDATTKKFKDPAVVAADMTTKGLDLTKNTIYAMCRAGNIASALFFYFDGILYNDGSKNVVWYDGSWGQWGLMSDNAAKGGKLPVGSAWATDSLTLPITYDADLGRTVVDITYRLDPTVSHATATANQIEDADKAYLSPVTSGGGGAGGGGGGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YF1</accession>
    <name>Q39YF1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513849.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0480"/>
    <dbReference type="EnsemblBacteria" id="ABB30723">
        <property type="protein sequence ID" value="ABB30723"/>
        <property type="gene ID" value="Gmet_0480"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0480"/>
    <dbReference type="eggNOG" id="COG2361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_3_3_7"/>
    <dbReference type="OMA" id="MRRDELY"/>
    <dbReference type="OrthoDB" id="1967941at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="116" mass="13114" checksum="71FF3900AF45E3AF" modified="2005-11-22" version="1">MKPRDLASLVDIIEAARLARSFLAGIAKNNFDSNLMVQSAVIRQIEVMGEATKRLSEEFRNDHPHVPWRKIAGMRDILIHAYDHVDPDEVWNVVTGAMPGLLEQLELLLKSQRLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YN4</accession>
    <name>Q39YN4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent protein deacetylase, Sir2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">srtN</name>
        <name evidence="4" type="ordered locus">Gmet_0397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512369.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0397"/>
    <dbReference type="DNASU" id="3739375"/>
    <dbReference type="EnsemblBacteria" id="ABB30640">
        <property type="protein sequence ID" value="ABB30640"/>
        <property type="gene ID" value="Gmet_0397"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0397"/>
    <dbReference type="eggNOG" id="COG0846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023643_2_0_7"/>
    <dbReference type="OMA" id="GGFWNAY"/>
    <dbReference type="OrthoDB" id="1264438at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="279" mass="30798" checksum="10269C005994EE1E" modified="2005-11-22" version="1">MDLQEKVRVAAEAVKHADAIVMTAGAGMGVDSGLPDFRGDTGFWKAYPPYQKLGITFVGAANPDHFERDPSFGWGFYGHRTNLYRATVPHAGFDILREWVQRYGLDYFVVTSNVDGQFQKAGFADDRILEVHGSIHHLQCTTPCTMAIWENRETIPVDEATMRAGHVPRCIHCGAVARPNILMFGDYGWVSDRSARQQRNFDEFLADTRGGRLVVVEMGAGTAIPTIRYLTEELGSRSEALAVRINPREPQIRAPHLSLPCGAREGVAAINAVLAEESP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YP4</accession>
    <name>HIS5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazole glycerol phosphate synthase subunit HisH</fullName>
            <ecNumber evidence="1">4.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">IGP synthase glutaminase subunit</fullName>
            <ecNumber evidence="1">3.5.1.2</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">IGP synthase subunit HisH</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ImGP synthase subunit HisH</fullName>
            <shortName evidence="1">IGPS subunit HisH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisH</name>
        <name type="ordered locus">Gmet_0387</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + H(+) + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterodimer of HisH and HisF.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="4.3.2.10" evidence="1"/>
    <dbReference type="EC" id="3.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512359.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YP4"/>
    <dbReference type="SMR" id="Q39YP4"/>
    <dbReference type="STRING" id="269799.Gmet_0387"/>
    <dbReference type="EnsemblBacteria" id="ABB30630">
        <property type="protein sequence ID" value="ABB30630"/>
        <property type="gene ID" value="Gmet_0387"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0387"/>
    <dbReference type="eggNOG" id="COG0118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071837_2_2_7"/>
    <dbReference type="OMA" id="WVYFVHS"/>
    <dbReference type="OrthoDB" id="1726024at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42701">
        <property type="entry name" value="PTHR42701"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000495">
        <property type="entry name" value="Amidotransf_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000231724" description="Imidazole glycerol phosphate synthase subunit HisH">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00278"/>
        </source>
    </evidence>
    <sequence length="210" mass="23001" checksum="A4CDD3DF24E675DD" modified="2005-11-22" version="1">MATIAIIDYGMGNLRSVQKGFEKVGFEAVVTADPKVVLEAEKVVLPGVGAFRDCMRNLEQGGFVEPILTVIQDGRPFLGICVGMQLLFTDSVEFGLYQGLNVIPGHVLRFPEGMRERGEDLKVPHMGWNQLSIKRRPSAFSDVEDGANVYFVHSFYAKPDEEGVVAATSSYGIDFCAAVWKDNIVATQFHPEKSQAVGLSILKNFALSKA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YQ1</accession>
    <name>RF1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide chain release factor 1</fullName>
            <shortName evidence="1">RF-1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prfA</name>
        <name type="ordered locus">Gmet_0380</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Methylated by PrmC. Methylation increases the termination efficiency of RF1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512352.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YQ1"/>
    <dbReference type="SMR" id="Q39YQ1"/>
    <dbReference type="STRING" id="269799.Gmet_0380"/>
    <dbReference type="EnsemblBacteria" id="ABB30623">
        <property type="protein sequence ID" value="ABB30623"/>
        <property type="gene ID" value="Gmet_0380"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0380"/>
    <dbReference type="eggNOG" id="COG0216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036856_0_1_7"/>
    <dbReference type="OMA" id="ISDHRVG"/>
    <dbReference type="OrthoDB" id="928964at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00093">
        <property type="entry name" value="Rel_fac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004373">
        <property type="entry name" value="RF-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00019">
        <property type="entry name" value="prfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000263279" description="Peptide chain release factor 1">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="1">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00093"/>
        </source>
    </evidence>
    <sequence length="355" mass="40174" checksum="F3A715CD7B8D074B" modified="2005-11-22" version="1">MFDKIEELEIRYQELESLLAVPTVIANQPEFRKLSREHNDLTGLVEAYRRYKKVLAEIEGNRELLADPEMKEMAEAELEDLERQQEELEGEIKLLLLPKDPNDDRNVILEIRAGTGGDESALFAGDLFRMYSRFAERNRWKVEVMSASESERGGFKEVVALIEGQAVFAKLKYESGTHRVQRVPETEAQGRIHTSACTVAVLPEAEDIEIDINPVDLKIDVYRASGAGGQHVNKTESAVRITHLPTGIVVECQDERSQIKNRSKAMKVLKSRILDGLQQEQNARIAADRKQQVGSGDRSERIRTYNFPQGRMTDHRIGLTLYRLDALMEGDIAEVVDSLRAHYQMEALKAQAEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YR8</accession>
    <name>Q39YR8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4 6">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0363</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4 6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512335.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0363"/>
    <dbReference type="EnsemblBacteria" id="ABB30606">
        <property type="protein sequence ID" value="ABB30606"/>
        <property type="gene ID" value="Gmet_0363"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0363"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027938_6_3_7"/>
    <dbReference type="OMA" id="RHAPLWP"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00613"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PlsC" evidence="8">
        <location>
            <begin position="68"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="234" mass="25255" checksum="B1C3EC65581549F8" modified="2005-11-22" version="1">MLNGLIYLLFFVPLTAFFSVLAMLGGLVDSRGGLAHRCALAWSRAGLILAGVRLRVSGAEQVPAGEPVIFMGNHQGNFDILVLSRAVPRRFSWLAKEELFRIPLFGSAMRRAGYIPVDRSDGRKALRSLDAAAKRIRAGASVIVFPEGTRTVDGSLLPFKKGGFILAERAGVPIVPFTINGSMRVNPRNTCNLVRGAEISVRFGAPIPTSGSKALKGQPLMDRVRDSIQAGLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YT9</accession>
    <name>Q39YT9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Peptidoglycan-binding outer membrane protein, OMP_b-brl and OmpA domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ordered locus">Gmet_0342</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512313.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0342"/>
    <dbReference type="EnsemblBacteria" id="ABB30585">
        <property type="protein sequence ID" value="ABB30585"/>
        <property type="gene ID" value="Gmet_0342"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0342"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031536_2_0_7"/>
    <dbReference type="OMA" id="YDYLDKC"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1080.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003367">
        <property type="entry name" value="Thrombospondin_3-like_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028974">
        <property type="entry name" value="TSP_type-3_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02412">
        <property type="entry name" value="TSP_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103647">
        <property type="entry name" value="SSF103647"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223630" evidence="14">
        <location>
            <begin position="23"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="15">
        <location>
            <begin position="325"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB30585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="447" mass="47522" checksum="0298757DBEC34930" modified="2005-11-22" version="1">MKKQVAITVAAACLAFSATAHSESRIKEGALSVSPFGGYTFFDRDSDLKSRPTGGLRLGYNFTENVAVEGSGAYTDTKYDNGNGSSNVYRYGAELLYHFIPQSRVVPFLAAGLGGITYEGREGVPDADRTDGILTAGGGVKLFLVDRIALRADGRNIFTFNDALNHQEVTAGLDFQFGGGKAAPAPVKAEPKPEPKPEPKKVVATAPLDSDGDGVPDNLDKCPDTPAGVKVDSVGCPLDSDGDGVPDYLDKCPGTPAGVKVDSVGCPLDSDGDGVPDYLDKCPGTPAGVKVDSVGCPLDTDGDGVPDYLDKCPDTPKNAAVDKNGCPEKVCITLKVEFDFDKANIKPEFRDEIKRVADFLKEYPDATAVIEGHTDSKGTVKYNQKLSERRAKAVMKNLVDEFGISAKRLSAKGYGETKPVADNATEEGRQKNRRVVANIDCGLKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YX3</accession>
    <name>Q39YX3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0306</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514018.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0306"/>
    <dbReference type="EnsemblBacteria" id="ABB30551">
        <property type="protein sequence ID" value="ABB30551"/>
        <property type="gene ID" value="Gmet_0306"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0306"/>
    <dbReference type="eggNOG" id="COG0074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_317797_0_0_7"/>
    <dbReference type="OMA" id="CVNVDAV"/>
    <dbReference type="OrthoDB" id="52243at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032875">
        <property type="entry name" value="Succ_CoA_lig_flav_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13607">
        <property type="entry name" value="Succ_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="SSF48256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="3">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_CoA_lig" evidence="4">
        <location>
            <begin position="175"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="909" mass="99457" checksum="ED4B02709FBA9F79" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z05</accession>
    <name>Q39Z05_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type VI secretion system ATPase and inner membrane protein TssM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tssM</name>
        <name evidence="3" type="ordered locus">Gmet_0274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513591.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0274"/>
    <dbReference type="EnsemblBacteria" id="ABB30519">
        <property type="protein sequence ID" value="ABB30519"/>
        <property type="gene ID" value="Gmet_0274"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0274"/>
    <dbReference type="eggNOG" id="COG3523">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004067_0_0_7"/>
    <dbReference type="OMA" id="APTEDCD"/>
    <dbReference type="OrthoDB" id="393769at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025743">
        <property type="entry name" value="IcmF-related_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14331">
        <property type="entry name" value="IcmF-related_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="IcmF-related_N" evidence="2">
        <location>
            <begin position="185"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1154" mass="126107" checksum="F3C99FB6B0D26716" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z07</accession>
    <name>Q39Z07_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513589.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0272"/>
    <dbReference type="EnsemblBacteria" id="ABB30517">
        <property type="protein sequence ID" value="ABB30517"/>
        <property type="gene ID" value="Gmet_0272"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0272"/>
    <dbReference type="HOGENOM" id="CLU_174771_1_0_7"/>
    <dbReference type="OrthoDB" id="2071969at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223634" evidence="1">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="103" mass="11597" checksum="61BD1F525BE31293" modified="2005-11-22" version="1">MSRFVLIIPFGALSLMLAACSSFPWLTKEEPAATSAPTAKNRCLLESEDCPPRKMTITELIAGLKHEIARGEAVYTPAELQKLENKLRDYEVMYDRLMYGNDD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z73</accession>
    <name>OTC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ornithine carbamoyltransferase</fullName>
            <shortName evidence="2">OTCase</shortName>
            <ecNumber evidence="2">2.1.3.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">argF</name>
        <name type="ordered locus">Gmet_0205</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>carbamoyl phosphate + L-ornithine = H(+) + L-citrulline + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512794.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z73"/>
    <dbReference type="SMR" id="Q39Z73"/>
    <dbReference type="STRING" id="269799.Gmet_0205"/>
    <dbReference type="EnsemblBacteria" id="ABB30451">
        <property type="protein sequence ID" value="ABB30451"/>
        <property type="gene ID" value="Gmet_0205"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0205"/>
    <dbReference type="eggNOG" id="COG0078">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043846_3_2_7"/>
    <dbReference type="OMA" id="DGNNVCN"/>
    <dbReference type="OrthoDB" id="988597at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00112"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004585">
        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01109">
        <property type="entry name" value="OTCase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002292">
        <property type="entry name" value="Orn/put_carbamltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024904">
        <property type="entry name" value="OTCase_ArgI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00102">
        <property type="entry name" value="OTCASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="SSF53671"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000065093" description="Ornithine carbamoyltransferase">
        <location>
            <begin position="1"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="130"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="226"/>
            <end position="227"/>
        </location>
        <ligand>
            <name>L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="262"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>carbamoyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01109"/>
        </source>
    </evidence>
    <sequence length="303" mass="33943" checksum="F0FCA05EAA973124" modified="2005-11-22" version="1">MTRHFLALNQYTKEALDALFALTRELKEEQKKGIPHRILEGKSVALIFEKSSTRTRISFEVGVHQLGAHPLFISSATSQMGRGEPVRDTARVMARYCDGVMIRTYGQEIVEEFARYSSVPVINGLTDLFHPCQIMADLFTVIEHKGKYDGLKFAWVGDGNNMANTWIEAAAILGFDLALACPEGYEPDRTVWDWAQKKATSSITITRDPKEAVRDADVVNTDVWASMGQEQEQKVREVAFKGYCLDDDLVALAKPDCMVLHCLPAHRGEEITDSVIEGPRSAVWDEAENRLHVQKAIMASLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZA1</accession>
    <name>Q39ZA1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mercuric reductase</fullName>
            <ecNumber evidence="5">1.16.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Hg(II) reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="primary">lpdA-3</name>
        <name evidence="18" type="ordered locus">Gmet_0177</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + Hg + NADP(+) = Hg(2+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:23856"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16170"/>
            <dbReference type="ChEBI" id="CHEBI:16793"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="13">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.1" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512764.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0177"/>
    <dbReference type="EnsemblBacteria" id="ABB30423">
        <property type="protein sequence ID" value="ABB30423"/>
        <property type="gene ID" value="Gmet_0177"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0177"/>
    <dbReference type="eggNOG" id="COG1249">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016755_1_2_7"/>
    <dbReference type="OMA" id="GTCINWG"/>
    <dbReference type="OrthoDB" id="267896at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016152">
        <property type="term" value="F:mercury (II) reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045340">
        <property type="term" value="F:mercury ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016668">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050787">
        <property type="term" value="P:detoxification of mercury ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021179">
        <property type="entry name" value="Mercury_reductase_MerA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02053">
        <property type="entry name" value="MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 15" id="KW-0274">FAD</keyword>
    <keyword evidence="7 15" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11 15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="17">
        <location>
            <begin position="6"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="16">
        <location>
            <begin position="346"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="178"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="14">
        <location>
            <begin position="43"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB30423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="469" mass="49392" checksum="D425D6F590F6FFE4" modified="2005-11-22" version="1">MPDDTHDLVILGSGSTAFAAALRAQSYGTRVLMVEKGVPGGTCINWGCVPSKTLIHAALFYQEGKLGARLGLGECGGTVVLERLMARKDQVVGHLRQTKYLDILQDVPGLQLVKGTGRFLGPDRLEVGDREIRSERFLVAVGGDPRVPRIPGLESTPFLTSRGTLLLKTIPQSLVIIGGGVIAVEMGQMFQRLGAKVTILEHGPRILGPVEPEPALAVRDFLRAEGMKIVCRTTICLAAQDGAGVRVEAERDGERVSFTAEKLLVATGTAPATNGIGLELAGVETDPRGFVTVDERMRTTAPGIWAAGDCTGGMMIATVGAREGIVAVDDMLNPGCGCSMDFLSAPMAIFTDPEVGMVGHTEEGAKAAGFDVVVNVMPVAAIPKAHVTGHTAGVIKMVADKATGRLLGVHLACHRGADIINEAALAIRFRATVEDLANALHVYPSMGEGLRLCAQGFSRDISRLSCCAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZD2</accession>
    <name>Q39ZD2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512728.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0143"/>
    <dbReference type="EnsemblBacteria" id="ABB30392">
        <property type="protein sequence ID" value="ABB30392"/>
        <property type="gene ID" value="Gmet_0143"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0143"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071268_0_0_7"/>
    <dbReference type="OMA" id="LWEYPNF"/>
    <dbReference type="OrthoDB" id="1549833at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223467" evidence="2">
        <location>
            <begin position="22"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="341" mass="37986" checksum="5B57D190855ACAE9" modified="2005-11-22" version="1">MKRIIQWICLAALALAAFGCAHDPFNIPRADYEQKVKVLGVAPIFMDADSDIRHPEKDTLVTLVREYNRKNEKELAEMIKESGAYFSVRFLDAAAPDELYRTLLLRAERRDDAGVVYNKQFFKPEEIRTLVTQNNVDAVLLVTVSGLTMRDRIFSSNLVKYLDSDYNVLSASAQILDANGATLWEYPNFRAGSPSTPVLAELQYPDFDEGAANMDERINVKFKTIPGLTRYLGKKEKDLLFRERKATVPYYHLFDEMVELLKPPIKLFGDEKKGGSAPQPASYQPQPASQPSYQPAPQPAPASKAAPAPAAQPVPAPQPESVAVPEPTPIREVPIDAKPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZE7</accession>
    <name>Q39ZE7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UvrABC system protein A</fullName>
            <shortName evidence="13">UvrA protein</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Excinuclease ABC subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13 16" type="primary">uvrA</name>
        <name evidence="16" type="ordered locus">Gmet_0128</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a heterotetramer with UvrB during the search for lesions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the ABC transporter superfamily. UvrA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514133.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0128"/>
    <dbReference type="EnsemblBacteria" id="ABB30377">
        <property type="protein sequence ID" value="ABB30377"/>
        <property type="gene ID" value="Gmet_0128"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0128"/>
    <dbReference type="eggNOG" id="COG0178">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001370_0_2_7"/>
    <dbReference type="OMA" id="PFEGIIP"/>
    <dbReference type="OrthoDB" id="152379at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00205">
        <property type="entry name" value="UvrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004602">
        <property type="entry name" value="UvrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041552">
        <property type="entry name" value="UvrA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041102">
        <property type="entry name" value="UvrA_inter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17755">
        <property type="entry name" value="UvrA_DNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17760">
        <property type="entry name" value="UvrA_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00630">
        <property type="entry name" value="uvra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 13" id="KW-0228">DNA excision</keyword>
    <keyword evidence="12 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="2 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 13" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0742">SOS response</keyword>
    <keyword evidence="8 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="319"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="15">
        <location>
            <begin position="605"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="13">
        <location>
            <begin position="737"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 14">
        <location>
            <begin position="638"/>
            <end position="645"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB30377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="937" mass="104116" checksum="2EB068F9F2998F48" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZI9</accession>
    <name>Q39ZI9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">[acyl-]glycerolphosphate acyltransferase and acyl-(Acyl carrier protein) ligase, major facilitator superfamily domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365621.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0086"/>
    <dbReference type="EnsemblBacteria" id="ABB30335">
        <property type="protein sequence ID" value="ABB30335"/>
        <property type="gene ID" value="Gmet_0086"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0086"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008489_1_0_7"/>
    <dbReference type="OMA" id="ANWVYLE"/>
    <dbReference type="OrthoDB" id="961884at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="7">
        <location>
            <begin position="12"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1128" mass="120589" checksum="C360F99670E3D277" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZM7</accession>
    <name>Q39ZM7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridine synthase, RluA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514171.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0047"/>
    <dbReference type="EnsemblBacteria" id="ABB30297">
        <property type="protein sequence ID" value="ABB30297"/>
        <property type="gene ID" value="Gmet_0047"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0047"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_1_2_7"/>
    <dbReference type="OMA" id="MLHCRAM"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="87"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="295" mass="32263" checksum="43A5358C1A2ECF2F" modified="2005-11-22" version="1">MILTGRAGEGEAGMRLDDGAVRLFPQLSKTRVRKIIDWGGCAVAGAMVRVASRTLRAGEEIVLGVMEPERYQELAYTRDDLLFENDDYLAVNKAAGLNCQRTPYQLKGTVEHAVTLYLRTLGSQEPARVIHRLDRGTSGVMIFPKTKRAAAHISAQLKEGRVEKVYWALVTAEPASDQWEVNAPIAKVGSARYGVATPGREALTRFAVIARGTCGVLVEARPLTGRTHQIRVHLAHCGLPIVGDPTYGGEKAPRMMLHCRAMSFTAADRRPITAEAPLDDPFRDACASRGIILEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZN8</accession>
    <name>Q39ZN8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4126 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0036</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513803.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0036"/>
    <dbReference type="EnsemblBacteria" id="ABB30286">
        <property type="protein sequence ID" value="ABB30286"/>
        <property type="gene ID" value="Gmet_0036"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0036"/>
    <dbReference type="eggNOG" id="ENOG502Z9HI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086377_0_0_7"/>
    <dbReference type="OMA" id="WASGINL"/>
    <dbReference type="OrthoDB" id="1828070at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025196">
        <property type="entry name" value="DUF4126"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13548">
        <property type="entry name" value="DUF4126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4126" evidence="2">
        <location>
            <begin position="8"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="202" mass="21356" checksum="A560E5C171510E56" modified="2005-11-22" version="1">MDILALLGTATGIALFSGLRLYTTILAIGLALRFGSFHLPQGLAGLSVLADWRVLAIAAACFVVEFLADKIPLVDTVWDGIHTFIRPIGAAVLGYTVIGNYDPWIQVAIVLACGGIGFTAHSAKAGTRVILNQSPEPISNIGASLVEDLFAVGGSLIALTHPLLMLGGVVVFLLVFAFLARKIVHLLIGRFRRPRGDMNAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZR0</accession>
    <name>Q39ZR0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transport permease protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0014</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell inner membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC-2 integral membrane protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513779.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0014"/>
    <dbReference type="EnsemblBacteria" id="ABB30264">
        <property type="protein sequence ID" value="ABB30264"/>
        <property type="gene ID" value="Gmet_0014"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0014"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_3_2_7"/>
    <dbReference type="OMA" id="YSAFSRM"/>
    <dbReference type="OrthoDB" id="1891092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC_2_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006648">
        <property type="entry name" value="DrrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00164">
        <property type="entry name" value="ABC2TRNSPORT"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="ABC2_membrane" evidence="7">
        <location>
            <begin position="7"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="251" mass="26992" checksum="85FB0887BF01E33D" modified="2005-11-22" version="1">MFKGAFSIWKRDMLVLRRSLFSELVAVVASPLTFYLAFGFGLRGYIADVEGVPYTVFMAPGLITMTAVSAAFDESAWSMWFHRKVQRTIEAYRVTPITVYDIVIGKIISGFSQGALKGVAVATVIFLLTGVRFDPAHLAGYLAFIVLGSMVFSCAGTVCGTLLDKPETIGKVQAVVIMPLIFLSGVFFPVSSYPEAMRSAVMLIPTTALFEGSRRALLAGAFDGGLIGILAVTALVAFAATVAIFNRKMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZR9</accession>
    <name>Q39ZR9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA gyrase subunit A</fullName>
            <ecNumber evidence="8">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">gyrA</name>
        <name evidence="11" type="ordered locus">Gmet_0005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the type II topoisomerase GyrA/ParC subunit family.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513724.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0005"/>
    <dbReference type="EnsemblBacteria" id="ABB30255">
        <property type="protein sequence ID" value="ABB30255"/>
        <property type="gene ID" value="Gmet_0005"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0005"/>
    <dbReference type="eggNOG" id="COG0188">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002977_6_1_7"/>
    <dbReference type="OMA" id="THHWLLF"/>
    <dbReference type="OrthoDB" id="217468at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034335">
        <property type="term" value="F:DNA negative supercoiling activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01897">
        <property type="entry name" value="GyrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005743">
        <property type="entry name" value="GyrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006691">
        <property type="entry name" value="GyrA/parC_rep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035516">
        <property type="entry name" value="Gyrase/topoIV_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03989">
        <property type="entry name" value="DNA_gyraseA_C"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101904">
        <property type="entry name" value="SSF101904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="SSF56719"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="TOP4c" evidence="10">
        <location>
            <begin position="11"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GyrA-box" evidence="8">
        <location>
            <begin position="551"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="840"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="8">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="857" mass="95949" checksum="8F29BEF6881FCA92" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>J7LWF8</accession>
    <name>J7LWF8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_A3644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="AFR42864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514714.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3644"/>
    <dbReference type="EnsemblBacteria" id="AFR42864">
        <property type="protein sequence ID" value="AFR42864"/>
        <property type="gene ID" value="Gmet_A3644"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3644"/>
    <dbReference type="HOGENOM" id="CLU_2553422_0_0_7"/>
    <dbReference type="OrthoDB" id="787596at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="82" mass="9239" checksum="671802116ED79A66" modified="2012-10-31" version="1">MAAQRFFEIGSRGFVVNFRIMCRGGFQAHCQDVPHRAKGTTIDGAFSAFLETLPDAWVDGVIDSLPVQDQRQVRLWRQDEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2022-05-25" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYB7</accession>
    <name>J7LYB7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3646"/>
    <dbReference type="EnsemblBacteria" id="AFR42788">
        <property type="protein sequence ID" value="AFR42788"/>
        <property type="gene ID" value="Gmet_3646"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3646"/>
    <dbReference type="eggNOG" id="ENOG502ZXSZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_212074_0_0_7"/>
    <dbReference type="OMA" id="VGAFCIY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="56" mass="6341" checksum="D5C59FEFE23DBB70" modified="2012-10-31" version="1">MKKLLSWGAVGLLTSALLDPLIYSMLEKPIPWLRDILMGAGGCVCFYLLIRFRNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2022-05-25" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>J7M068</accession>
    <name>J7M068_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin family protein, selenocysteine-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">trx-3</name>
        <name evidence="2" type="ordered locus">Gmet_0151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0151"/>
    <dbReference type="KEGG" id="gme:Gmet_0151"/>
    <dbReference type="eggNOG" id="COG3118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090389_10_0_7"/>
    <dbReference type="OMA" id="LSEHPNC"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <keyword evidence="2" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="38"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="2">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="16089" checksum="3D8620088EA69379" modified="2012-10-31" version="1">MAASGESFLVTCSACGTANRVPAEKEGVAGRCGNCRGTLPPLYLHPVPLTDRSFDPFVAGYPGPVLTEFWAPWUPHCQRFAPVVREIARELAGRGVVAQVNTQGNPQVASRFGIRGIPALVLLQRGKILGSLNGAQSKESVLSWVRSTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2022-05-25" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEN4</accession>
    <name>J9JEN4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3606</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3606"/>
    <dbReference type="EnsemblBacteria" id="AFR42826">
        <property type="protein sequence ID" value="AFR42826"/>
        <property type="gene ID" value="Gmet_3606"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3606"/>
    <dbReference type="eggNOG" id="ENOG5033BVP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_206536_0_0_7"/>
    <dbReference type="OMA" id="TCCGEVI"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="51" mass="5933" checksum="F8C9ACF0D810A174" modified="2012-10-31" version="1">MKCPKCKGRMFAEKFYDFVRSFDAWKCTCCGEVIDPTILANRARNHNLFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PP8</accession>
    <name>Q39PP8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_A3571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="3">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="3">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="3">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33776.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514723.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3571"/>
    <dbReference type="EnsemblBacteria" id="ABB33776">
        <property type="protein sequence ID" value="ABB33776"/>
        <property type="gene ID" value="Gmet_A3571"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3571"/>
    <dbReference type="HOGENOM" id="CLU_138441_0_0_7"/>
    <dbReference type="OMA" id="NEKPCID"/>
    <dbReference type="OrthoDB" id="1845627at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0614">Plasmid</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33776.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="162" mass="17956" checksum="A85B1FD84C032BF1" modified="2012-10-31" version="2">MANVTITEAARLAGISRQYLYTKYIKPGVLTVKKDENEKPCIDTAELMRVFNGRLPGPKGQSTPDPSSDIHALQNMTRENDIKNAALQAEVEALREAIKAADKRETWLQGKVDELTGQLATAHRLLEHKAHPSEPPPADPVPVPDPPQEPKRGFFGRLFGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PZ8</accession>
    <name>Q39PZ8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Malto-oligosyltrehalose trehalohydrolase</fullName>
            <shortName evidence="8">MTHase</shortName>
            <ecNumber evidence="3 8">3.2.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">4-alpha-D-((1-&gt;4)-alpha-D-glucano)trehalose trehalohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6 8">Maltooligosyl trehalose trehalohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">treZ</name>
        <name evidence="13" type="ordered locus">Gmet_3467</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Glycan biosynthesis; trehalose biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.141" evidence="3 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513918.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3467"/>
    <dbReference type="CAZy" id="CBM48">
        <property type="family name" value="Carbohydrate-Binding Module Family 48"/>
    </dbReference>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33676">
        <property type="protein sequence ID" value="ABB33676"/>
        <property type="gene ID" value="Gmet_3467"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3467"/>
    <dbReference type="eggNOG" id="COG0296">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020726_2_0_7"/>
    <dbReference type="OMA" id="FTPMLFM"/>
    <dbReference type="OrthoDB" id="148706at2"/>
    <dbReference type="UniPathway" id="UPA00299"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033942">
        <property type="term" value="F:4-alpha-D-(1-&gt;4)-alpha-D-glucanotrehalose trehalohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022567">
        <property type="entry name" value="DUF3459"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012768">
        <property type="entry name" value="Trehalose_TreZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044901">
        <property type="entry name" value="Trehalose_TreZ_E-set_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11941">
        <property type="entry name" value="DUF3459"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006337">
        <property type="entry name" value="Trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="SSF81296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02402">
        <property type="entry name" value="trehalose_TreZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="90"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="259"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="323"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="391"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="261"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR006337-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB33676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="612" mass="68343" checksum="6D43E417BF1EE486" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q04</accession>
    <name>Q39Q04_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybhS-2</name>
        <name evidence="7" type="ordered locus">Gmet_3461</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513912.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3461"/>
    <dbReference type="EnsemblBacteria" id="ABB33670">
        <property type="protein sequence ID" value="ABB33670"/>
        <property type="gene ID" value="Gmet_3461"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3461"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_8_3_7"/>
    <dbReference type="OMA" id="ILHIPFQ"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="369" mass="40487" checksum="0971D31550ADAE97" modified="2005-11-22" version="1">MKLSRIRAIAKKELIQVIRDPLSLAMAFLMPVILLFIFGYAITMDVNNLRTVVYDLDRSSLSRELVSQFRESGYFTIVATLEQGGDIDAALDANRGQVALWIPEDFSENLRRGKSAPLQVVVDGSDSNTATIALGYVEAVAERFSQRTSGGLATPTIDPRVRVWYNPELKSRNYIIPGLIAVIMAVIAALLTSLTIAREWERGTMEQLIATPVKPTELIAGKLIPYFFIGFIDVALSVAMATLIFDVPLRGSLLLLALLSSLFLFGGLSLGILISVVARSQLVASQIAMVVSFLPAFLLSGFMYAIANMPTPLRNVTRVIPARYFVSILKGIFLKGSTLRLLAAETALLALFGVVVFILSVRKFRKRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q21</accession>
    <name>Q39Q21_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3441</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514669.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3441"/>
    <dbReference type="EnsemblBacteria" id="ABB33653">
        <property type="protein sequence ID" value="ABB33653"/>
        <property type="gene ID" value="Gmet_3441"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3441"/>
    <dbReference type="eggNOG" id="ENOG5033C6Q">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1376433_0_0_7"/>
    <dbReference type="OMA" id="FHKVVTV"/>
    <dbReference type="OrthoDB" id="1731686at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="196" mass="21561" checksum="966D2203EDFF6602" modified="2005-11-22" version="1">MNGTSPPVEQLIACQQVLMDDSTVFSIQWMTMPESGVAGVTPDLLFDRYLAYIRRFTRSLVRPKVTDNGVEFRLLGLPVSLISFASPVRSEEENRASLSLPISGGLLVLAGQGALSFLVEEAAGGVRLTLRLAHSRPLLLGSAPVSPLRKFLYRFTQAHIHKVVTVRFLARLYRQLTGCAARARVVPVRVCQGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q24</accession>
    <name>Q39Q24_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix transcriptional regulator with cupin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3438"/>
    <dbReference type="EnsemblBacteria" id="ABB33650">
        <property type="protein sequence ID" value="ABB33650"/>
        <property type="gene ID" value="Gmet_3438"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3438"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085376_3_2_7"/>
    <dbReference type="OMA" id="TGMTKSY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="198" mass="22811" checksum="BD01422ABE4EDDFE" modified="2005-11-22" version="1">MTVPDIKSQIKELRLGEKVRKLRQEQRLTLQELSELSGLSKPLLSQIENDQVTPPIATLLKISKGLKVGIHYFFEEEEDQQKLVLTRASQQTATRRRTGNDAPHGYVYRSLAPGIRHKPMEPFLVEFELTEWDDAFFYRHDGFEFIYLLEGELEFHYGTDIMRLNPGDSIYYDSSEPHGYVSVGEQKATAVAVLYSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q71</accession>
    <name>Q39Q71_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminodeoxyfutalosine synthase</fullName>
            <shortName evidence="6">AFL synthase</shortName>
            <shortName evidence="6">Aminofutalosine synthase</shortName>
            <ecNumber evidence="6">2.5.1.120</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnE</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mqnC-2</name>
        <name evidence="6" type="synonym">mqnE</name>
        <name evidence="8" type="ordered locus">Gmet_3391</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-[(1-carboxyvinyl)-oxy]benzoate + H2O + S-adenosyl-L-methionine = 6-amino-6-deoxyfutalosine + H(+) + hydrogencarbonate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33075"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64286"/>
            <dbReference type="ChEBI" id="CHEBI:76981"/>
            <dbReference type="EC" id="2.5.1.120"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnE family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.120" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512617.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3391"/>
    <dbReference type="EnsemblBacteria" id="ABB33603">
        <property type="protein sequence ID" value="ABB33603"/>
        <property type="gene ID" value="Gmet_3391"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3391"/>
    <dbReference type="eggNOG" id="COG1060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040406_1_0_7"/>
    <dbReference type="OMA" id="HIKAYWA"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102573">
        <property type="term" value="F:aminodeoxyfutalosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00993">
        <property type="entry name" value="MqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022432">
        <property type="entry name" value="MqnE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03700">
        <property type="entry name" value="mena_SCO4494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="50"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="71"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="360" mass="39882" checksum="B976F03A4CBBB232" modified="2005-11-22" version="1">MTSLSSISEKVHAGERITDEEALFLFECRDLIAVGELAATANRRRNGDRVFFNVNRHINHTNICVNRCSFCAFYRTADQPGAYLYDLEEIRNRALEAHAQGATEIHIVGGLHPDLPFDFYLEMLRTVKSVSPELHLKAFTAVEIEYLSKLAGLSVAETLAELKGAGLGSLPGGGAEIFAPDVRSRLCPEKISGERWLAVMEEVHRAGLKSNATMLFGHIESYADRVDHMRRLRELQDRTGGFQVFIPLAFQMENNPLGHLKRPGPGGVDALKTLAVGRIYLDNFANIKAYWVMLGLKTAQVALSFGVNDLDGTVVEEKIGHDAGAATPQTMGRDEIVTLIRTAGRVPVERDTLYNELRVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QC4</accession>
    <name>Q39QC4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Primosomal protein N'</fullName>
            <ecNumber evidence="9">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent helicase PriA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">priA</name>
        <name evidence="11" type="ordered locus">Gmet_3337</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the primosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the helicase family. PriA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512562.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3337"/>
    <dbReference type="EnsemblBacteria" id="ABB33550">
        <property type="protein sequence ID" value="ABB33550"/>
        <property type="gene ID" value="Gmet_3337"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3337"/>
    <dbReference type="eggNOG" id="COG1198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013353_3_1_7"/>
    <dbReference type="OMA" id="RCHYCGY"/>
    <dbReference type="OrthoDB" id="1132322at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990077">
        <property type="term" value="C:primosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006268">
        <property type="term" value="P:DNA unwinding involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00983">
        <property type="entry name" value="PriA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005259">
        <property type="entry name" value="PriA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041222">
        <property type="entry name" value="PriA_3primeBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042115">
        <property type="entry name" value="PriA_3primeBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041236">
        <property type="entry name" value="PriA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040498">
        <property type="entry name" value="PriA_CRR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17764">
        <property type="entry name" value="PriA_3primeBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18074">
        <property type="entry name" value="PriA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18319">
        <property type="entry name" value="PriA_CRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00595">
        <property type="entry name" value="priA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="227"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="451"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="9">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="746" mass="82537" checksum="5761AF9256CE1694" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QK5</accession>
    <name>Q39QK5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512694.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3256"/>
    <dbReference type="EnsemblBacteria" id="ABB33469">
        <property type="protein sequence ID" value="ABB33469"/>
        <property type="gene ID" value="Gmet_3256"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3256"/>
    <dbReference type="eggNOG" id="COG5386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548310_0_0_7"/>
    <dbReference type="OMA" id="WKTRRIK"/>
    <dbReference type="OrthoDB" id="483611at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036426">
        <property type="entry name" value="Bulb-type_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51110">
        <property type="entry name" value="SSF51110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223426" evidence="1">
        <location>
            <begin position="24"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="510" mass="55409" checksum="6E57DFC8136E57E0" modified="2005-11-22" version="1">MKRLSLLCAVLFVALTAASTLFAAQIRVYVSEFAVTGAANKDELKSTLQTLFASRLSNDSVLSVDSPVGADVLVKGSYIAFGKVFSLDAVAKDTSGRVIARSFQQGESQDELIPAAGKLGQSLAAEIAAKVKPGVVMVPQPVVQPVAAPVPVPVSDVVRPSAPQPAADVVKASTTSDIVKPQDLTRTASGGWMSQRLTGTLIGIAPGKAAADGTRDFYVADEQALRLYRKREGLKLVAEVSFSPGDRVIAVDSADLDGDGTPEAYLTVLNGDSLASQVWVAEKDSLKRVAAKLPYYFRGIALNGKEYKMYAQQMSTDKDFYGDVYEVVKAGDRFELKNPIKLPRFGYLYNFNQFRDAAGNSCTAVLNDDGYLIVYSAAGEELWRSSDKFGGSETYFKREDLANVQRTGDPFRWVFLEQRITVSPSGEVIVPKNEGMFVIGNNRAYKKSSIYAFTWNGSSLDEVWHTKQSQSYLADYLYDGARKELVALEVVKKEGLLDKGASVVVVKRVE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QR2</accession>
    <name>PROA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Gamma-glutamyl phosphate reductase</fullName>
            <shortName evidence="1">GPR</shortName>
            <ecNumber evidence="1">1.2.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glutamate-5-semialdehyde dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glutamyl-gamma-semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">GSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proA</name>
        <name type="ordered locus">Gmet_3199</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the gamma-glutamyl phosphate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512637.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QR2"/>
    <dbReference type="SMR" id="Q39QR2"/>
    <dbReference type="STRING" id="269799.Gmet_3199"/>
    <dbReference type="EnsemblBacteria" id="ABB33412">
        <property type="protein sequence ID" value="ABB33412"/>
        <property type="gene ID" value="Gmet_3199"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3199"/>
    <dbReference type="eggNOG" id="COG0014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030231_0_0_7"/>
    <dbReference type="OMA" id="PGVCNAM"/>
    <dbReference type="OrthoDB" id="223669at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000230004" description="Gamma-glutamyl phosphate reductase">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00412"/>
        </source>
    </evidence>
    <sequence length="418" mass="45716" checksum="D8B9A239F7272994" modified="2005-11-22" version="1">MTIAEQIRTIAADARQAAIAMAKLPTTAKNDLLMAMAMALISNTPHLIDENRKDLEAGEKKGLSSAMLDRLMLDEARIKAMADGLREVAGLPDPVGEVTRMWKRPNNLMVGKMRIPLGVIGIIYEARPNVTADAAALCLKAGNSVILRGGSEAIHSNLAIARILGEEMERAGIPKAALSVIPFPEREGVLEMLKQEEFIDLIIPRGGESLIRFVVEHSKIPVIKHYKGVCHVFVDASADFDMAERIVVNAKVQRPGVCNALETLLIHKDVAEAFIPRIAATLTDLKVELRGDDCVRQFAPQAKKATEEDWQAEYLELILAVRVVDGLNEAIDHINAYGSLHTEAIVTRDYHNSQRFIREVNSSTVLVNASTRFADGNQLGLGAEIGISTTKLHSFGPMGLEDLTTTKFIVYGDGQVRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QU0</accession>
    <name>Q39QU0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rubredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_3171</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Rubredoxin is a small nonheme, iron protein lacking acid-labile sulfide. Its single Fe, chelated to 4 Cys, functions as an electron acceptor and may also stabilize the conformation of the molecule.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
        <text evidence="7 8">Binds 1 Fe(3+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the rubredoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513887.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3171"/>
    <dbReference type="EnsemblBacteria" id="ABB33384">
        <property type="protein sequence ID" value="ABB33384"/>
        <property type="gene ID" value="Gmet_3171"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3171"/>
    <dbReference type="eggNOG" id="COG1773">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128747_3_3_7"/>
    <dbReference type="OMA" id="APKDMFE"/>
    <dbReference type="OrthoDB" id="2047418at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00730">
        <property type="entry name" value="rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024922">
        <property type="entry name" value="Rubredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024935">
        <property type="entry name" value="Rubredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018527">
        <property type="entry name" value="Rubredoxin_Fe_BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00301">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000071">
        <property type="entry name" value="Rubredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00163">
        <property type="entry name" value="RUBREDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00202">
        <property type="entry name" value="RUBREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rubredoxin-like" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000071-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="52" mass="5739" checksum="5CF587CC17B52E36" modified="2005-11-22" version="1">MQSWRCTICQYIYDPAAGDPENGIAPGTPFEDLPDSWVCPLCGAGKEMFEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QU6</accession>
    <name>Q39QU6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ppcC</name>
        <name evidence="2" type="ordered locus">Gmet_3165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513881.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3165"/>
    <dbReference type="EnsemblBacteria" id="ABB33378">
        <property type="protein sequence ID" value="ABB33378"/>
        <property type="gene ID" value="Gmet_3165"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3165"/>
    <dbReference type="HOGENOM" id="CLU_188310_0_0_7"/>
    <dbReference type="OMA" id="VLCKGCH"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002322">
        <property type="entry name" value="Cyt_c_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00609">
        <property type="entry name" value="CYTOCHROMEC3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223167" evidence="1">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="95" mass="9882" checksum="2802458C9C24AC5C" modified="2005-11-22" version="1">MERKIHAAAVVAILILGAGAASAIETITFPNRIGQVSFPHKKHQDALGQCRGCHEKGPGEIDGFDKVLAHGKGCKGCHEAMKRGPVLCKGCHGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QY8</accession>
    <name>Q39QY8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rhodanese homology domain superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514297.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3122"/>
    <dbReference type="EnsemblBacteria" id="ABB33336">
        <property type="protein sequence ID" value="ABB33336"/>
        <property type="gene ID" value="Gmet_3122"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3122"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_1_5_7"/>
    <dbReference type="OMA" id="IDIYKGQ"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="1">
        <location>
            <begin position="39"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="127" mass="14003" checksum="C0144E53ABA4F7F7" modified="2005-11-22" version="1">MVMKQIAIFPMIVLALAVTVLAAGYRDIKASEAKSLLAANKKVFLLDVRTPEEFGQGRLQGAVLIPINEVERRIGEIPRNRPVVVYCAVGSRSGLVAGFLSRKGYREVYNMADGIVGWYRNGLPILR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R00</accession>
    <name>Q39R00_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar assembly protein FliH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">fliH</name>
        <name evidence="4" type="ordered locus">Gmet_3110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514285.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3110"/>
    <dbReference type="EnsemblBacteria" id="ABB33324">
        <property type="protein sequence ID" value="ABB33324"/>
        <property type="gene ID" value="Gmet_3110"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3110"/>
    <dbReference type="eggNOG" id="COG1317">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092008_0_0_7"/>
    <dbReference type="OMA" id="IQERNPA"/>
    <dbReference type="OrthoDB" id="1421082at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018035">
        <property type="entry name" value="Flagellar_FliH/T3SS_HrpE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02108">
        <property type="entry name" value="FliH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FliH" evidence="3">
        <location>
            <begin position="120"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="304" mass="32209" checksum="93FA6B784C52E2FC" modified="2005-11-22" version="1">MFSSKGRSRIIKAGEPSLHTPQGFTFGRILAEAPSQEPPEELPPGASGFVPLSLGFVSGGEELPDPVASIAEDPDPPMPSLEGMIVLSEEDFQAKVDEIYRNGMDEGRRQAERGLANVFKSLRDGVSAVTGLRSRLLKESEEDVLKLAVMVARKIVQQEITQDPAILTSIIAAAVGGCTERDRVVVRLNPNDYTVVAANRQAFLAGLGDDVPITLTPDDGVGPGGCLVETATGTVDARIESQLDEIYRTLLEERSAPVETALPAPAEPEPRGELPLPGADDVIPSFSGQGAWLKADGETTSVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R79</accession>
    <name>Q39R79_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase DUF294, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514344.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3030"/>
    <dbReference type="EnsemblBacteria" id="ABB33245">
        <property type="protein sequence ID" value="ABB33245"/>
        <property type="gene ID" value="Gmet_3030"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3030"/>
    <dbReference type="eggNOG" id="COG2905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027866_2_2_7"/>
    <dbReference type="OMA" id="REEMENP"/>
    <dbReference type="OrthoDB" id="301791at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018821">
        <property type="entry name" value="DUF294_put_nucleoTrafse_sb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005105">
        <property type="entry name" value="GlnD_Uridyltrans_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03445">
        <property type="entry name" value="DUF294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10335">
        <property type="entry name" value="DUF294_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF294" evidence="1">
        <location>
            <begin position="88"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="DUF294_C" evidence="2">
        <location>
            <begin position="263"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="398" mass="43947" checksum="15ED1744DE0D32A8" modified="2005-11-22" version="1">MALLLGARGEDILTRRGTAEFIEQVRQGLYVRMAHLSAGDEELLLLGVKDALEEELTAEQGCREDFSRVLDEADQAEDVRELMPIQDRLRAMAADYFSRRGSVAAYHLMRTVALDRITGAVLRITLSQMAAGGVGVPAGRWCWMALGAAGRGEVSRFDACDFLLVHEEIEAGSSFVGFSGRPAPLLERLSIGSRAGITPASSSWRGSLTEWRQRIAARAVEGGGDMEWLVRLADLRLVAGDPSLAAEMVNLVRSALSVQIDPLREIARRTAMMQSGFDFFGRLRLERGMFNLALYGIGPLVANVRIMTVRFDIQETATTERIRGLLYQGRIDVELAERLLRAWNCFYRHGIRREIAGENGILVDTEEFGEDAERELHASLEAVGSLQKIVYSSISGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RB3</accession>
    <name>Q39RB3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514487.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2996"/>
    <dbReference type="EnsemblBacteria" id="ABB33211">
        <property type="protein sequence ID" value="ABB33211"/>
        <property type="gene ID" value="Gmet_2996"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2996"/>
    <dbReference type="eggNOG" id="COG2960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_650358_0_0_7"/>
    <dbReference type="OrthoDB" id="2042175at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="448" mass="49713" checksum="A1E0E1EDF5B24148" modified="2005-11-22" version="1">MGWNLFRGRIRLPLLAAAIVFFSFPFQVWGGSAAPSDAERISELEKRLEEHAKIIEKLVERIRELEKKPPQESLEPVAAAGASSPPVEAVANAPAASGSDLSMFEDVTWLHGFADVGLTYSGRHQGDNAKRKGFSVGALDFYLTPQLGPRVKGLAELIFEVNNEGETMAELERLQIGYSFNDYLTLWGGRYHTPLGYWNTAFHHGKQIQTTILRPKFLDFEEDDGVLPVHMTGLWGSGSVRLGDGKMNYDLYVANGPKIKDLATGGDGRLEPNSFTDDNHNLALGFNVSYDFSGALDGLRLGAHGLRTDVDGYDAADQRLSRSELNILGGYGIYTTNDWEIIGEFYQFLNRDRSGGSGYHSSAAGFLQAGRLIGSFTPYARFEFASLDQKDNYFSRLKEGSSYRRGLAGVRFDLSPKTALKVEGDHTRILNREHDDYFEISSQLAIHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RF5</accession>
    <name>Q39RF5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase-related cysteine hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512887.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2952"/>
    <dbReference type="EnsemblBacteria" id="ABB33169">
        <property type="protein sequence ID" value="ABB33169"/>
        <property type="gene ID" value="Gmet_2952"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2952"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_5_3_7"/>
    <dbReference type="OMA" id="RDHYVEK"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="185" mass="19786" checksum="D34A26B81976A945" modified="2005-11-22" version="1">MKKALLVIDVQNEYFTGALPVTHPAGSFANILAAMDAATANGIPVVVVRHSSNRPGAASFQPGTPAWDLHPEVAQRPHDLLLEKQLPGSFTGTGLEAWLREREIGTVVISGYMTQMCCDTTSRQAFHRGFSVEFLSDATGTLAFANNAGSVTAEELHRTVLVTQQLMFATVMTTAAWVGSLAKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RJ1</accession>
    <name>Q39RJ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512851.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2915"/>
    <dbReference type="EnsemblBacteria" id="ABB33133">
        <property type="protein sequence ID" value="ABB33133"/>
        <property type="gene ID" value="Gmet_2915"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2915"/>
    <dbReference type="HOGENOM" id="CLU_189842_0_0_7"/>
    <dbReference type="OMA" id="IMVIMLQ"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223178" evidence="2">
        <location>
            <begin position="20"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="71" mass="7210" checksum="B53B584B6F36853D" modified="2005-11-22" version="1">MKTTLATMITLIAASSAFAASGAESEGSGLFLILFIGIGALIIVGQMLPGLTLFGSMLKGLFSGKDAESRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RL4</accession>
    <name>Q39RL4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Undecaprenyl-phosphate glycosyltransferase, DPM1-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512828.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2892"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33110">
        <property type="protein sequence ID" value="ABB33110"/>
        <property type="gene ID" value="Gmet_2892"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2892"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_0_0_7"/>
    <dbReference type="OMA" id="DLVSGWK"/>
    <dbReference type="OrthoDB" id="1064289at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="4"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="329" mass="36972" checksum="A165F3E99BCF2E41" modified="2005-11-22" version="1">MKLSIVIPIYNEEENIPPLYGRVTEALAGTGIDYELILVDDGSSDGSFPLLRQIAERDSRVKVIRFRRNFGQTAAMAAGFDAARGEVVVPMDGDLQNDPADIPMLLSKINEGYDVVSGWRKDRQDTFINRRLPSIIANGLISRMTGVHLHDYGCTLKAYRREVLDGVNLYGEMHRFVPALASQVGARVTELPVRHHPRLHGTSKYGISRTMRVVLDLMTVKFLLAYSTKPIQLFGKWGIYTLFAGFLSGGATLYFKFFEHINMNRNPLLILTAFLLFMGVQFIVLGLLGELNARTYYEAQGKPIYVIRERINVGDRGPGTGDRENRKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RN6</accession>
    <name>Q39RN6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein KhpA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">KH-domain protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">khpA</name>
        <name evidence="2" type="ordered locus">Gmet_2870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with KhpB.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KhpA RNA-binding protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514601.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2870"/>
    <dbReference type="EnsemblBacteria" id="ABB33088">
        <property type="protein sequence ID" value="ABB33088"/>
        <property type="gene ID" value="Gmet_2870"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2870"/>
    <dbReference type="eggNOG" id="COG1837">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132074_1_0_7"/>
    <dbReference type="OMA" id="AVKMDKR"/>
    <dbReference type="OrthoDB" id="1940160at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00088">
        <property type="entry name" value="UPF0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020627">
        <property type="entry name" value="KhpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34654">
        <property type="entry name" value="PTHR34654"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0133">Cell shape</keyword>
    <keyword evidence="1" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="76" mass="8443" checksum="3C027F8CF10AA508" modified="2005-11-22" version="1">MKELVETIAKALVDDPSQVRTTEEMEEDTMVIKLTVAKEDMGRIIGKEGRTAKAIRTLLNAVSTKDNKKAVLKIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RP4</accession>
    <name>Q39RP4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">NH(3)-dependent NAD(+) synthetase</fullName>
            <ecNumber evidence="4 6">6.3.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">nadE</name>
        <name evidence="9" type="ordered locus">Gmet_2862</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>ATP + deamido-NAD(+) + NH4(+) = AMP + diphosphate + H(+) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:21188"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 7">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (ammonia route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 5">Belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.5" evidence="4 6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514593.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2862"/>
    <dbReference type="EnsemblBacteria" id="ABB33080">
        <property type="protein sequence ID" value="ABB33080"/>
        <property type="gene ID" value="Gmet_2862"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2862"/>
    <dbReference type="eggNOG" id="COG0171">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059327_1_2_7"/>
    <dbReference type="OMA" id="MAFLYDY"/>
    <dbReference type="OrthoDB" id="1152435at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00333"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008795">
        <property type="term" value="F:NAD+ synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00193">
        <property type="entry name" value="NadE_ammonia_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022926">
        <property type="entry name" value="NH(3)-dep_NAD(+)_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="PTHR23090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_synthase" evidence="8">
        <location>
            <begin position="13"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="32"/>
            <end position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>deamido-NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="271" mass="30512" checksum="39C84807EB019919" modified="2005-11-22" version="1">MADVNVKLLRRILVGFIREEVTKVGIRKAVLGLSGGIDSALVAYLAAEALGPENIHACIMPYRTSNPESEAHARLAAEHLGIHYQVIDITPMIDAYFSRFPDADSMRRGNKMARERMTILYDHSAALPALVLGTSNKTELLLGYGTLYGDMASALNPIGDIYKTQVWQLSEEMGVPRDIIEKQPSADLWAGQTDEQELGFTYREVDKLLYSMVDQRMSREELEKNGFAADFIATVSARIQNSHFKRRLPIIAKVSNRTIDRDFRYSRDWGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RQ4</accession>
    <name>Q39RQ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2852</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2852"/>
    <dbReference type="EnsemblBacteria" id="ABB33070">
        <property type="protein sequence ID" value="ABB33070"/>
        <property type="gene ID" value="Gmet_2852"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2852"/>
    <dbReference type="HOGENOM" id="CLU_3043831_0_0_7"/>
    <dbReference type="OMA" id="IKRENWK"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="54" mass="6281" checksum="5D3C5801FE54897E" modified="2005-11-22" version="1">MKRNPDVNKLCLSCRRQCKQAATVVISSCPRYYPGPKIKRENWKQMELDLLSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RU7</accession>
    <name>Q39RU7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514675.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2809"/>
    <dbReference type="EnsemblBacteria" id="ABB33027">
        <property type="protein sequence ID" value="ABB33027"/>
        <property type="gene ID" value="Gmet_2809"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2809"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002338_2_1_7"/>
    <dbReference type="OMA" id="RYRAYGM"/>
    <dbReference type="OrthoDB" id="754526at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007452">
        <property type="entry name" value="TamB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04357">
        <property type="entry name" value="TamB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1377" mass="143906" checksum="53AABFD3D4D548D7" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RV0</accession>
    <name>Q39RV0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor-related protein YciH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yciH</name>
        <name evidence="5" type="ordered locus">Gmet_2806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514678.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2806"/>
    <dbReference type="EnsemblBacteria" id="ABB33024">
        <property type="protein sequence ID" value="ABB33024"/>
        <property type="gene ID" value="Gmet_2806"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2806"/>
    <dbReference type="eggNOG" id="COG0023">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082805_4_0_7"/>
    <dbReference type="OMA" id="KSKCGVG"/>
    <dbReference type="OrthoDB" id="1752091at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11567">
        <property type="entry name" value="YciH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005872">
        <property type="entry name" value="SUI1_arc_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037511">
        <property type="entry name" value="Transl_init_SUI1_pro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="SSF55159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="4">
        <location>
            <begin position="50"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="121" mass="12415" checksum="885D8E7BDC234AEB" modified="2005-11-22" version="1">MKKGSSSDAPLVWSSEHGRVCPGCGKPAAGCVCKKQQKSPAGDGIVRVRRESKGRGGKTVTVITGVPLGSDGIAALAGELKRRCGTGGTVKEGNIEIQGDHADLLVAELTKWGYTVKRAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S16</accession>
    <name>Q39S16_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32958.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366093.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2740"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32958">
        <property type="protein sequence ID" value="ABB32958"/>
        <property type="gene ID" value="Gmet_2740"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2740"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_17_3_7"/>
    <dbReference type="OMA" id="THGDQGF"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026461">
        <property type="entry name" value="Trfase_2_rSAM/seldom_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04283">
        <property type="entry name" value="glyco_like_mftF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="11"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32958.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="370" mass="41259" checksum="8AFF17D76F936435" modified="2012-10-31" version="2">MHDEPDHPELSITVPTLNEAEGLERFFAMLSAQQGVRFELVIADGGSTDGTPESARRLAAATPFAATVIETGRGRGRQMNAGAAAAAGDTLLFLHADCAFPDPLALRTALDAFTQTVAAGGSHRVAGHFRLRFERTDSAPSLPYYFYEWKARLHRPGCTHGDQGLLLGRRFFAEAGPFDESFPILEDVGLAERIAALGEWLLLPAEIVTSARRFEAEGLRERQTLNALLMNFAAMGWDPFLAELPRLYQSQDRAGRLLLGPVLRLIARLLRPLPRRERGRLWRETGRYVRANAWQIPFFLDVRRHFRQGTPVGEGETPRLDLHDRIFDRLTENGAGHRATALLVWIWFRLSLLREPLTPPAARNPEGNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S37</accession>
    <name>Q39S37_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2719</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511741.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2719"/>
    <dbReference type="EnsemblBacteria" id="ABB32937">
        <property type="protein sequence ID" value="ABB32937"/>
        <property type="gene ID" value="Gmet_2719"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2719"/>
    <dbReference type="HOGENOM" id="CLU_190608_0_0_7"/>
    <dbReference type="OMA" id="CEESCHA"/>
    <dbReference type="OrthoDB" id="2072155at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032587">
        <property type="entry name" value="DUF4911"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16256">
        <property type="entry name" value="DUF4911"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="81" mass="9039" checksum="BA3C7543BC446266" modified="2005-11-22" version="1">MYQPTEITRFFQVPRHDLAYLKFIVEAYEGLATLSTADRKTSTVVITYNSYFAGTLDALLKSLGTEIAIKEVSATEFSSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S51</accession>
    <name>Q39S51_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphate-specific transport system accessory protein PhoU</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">phoU</name>
        <name evidence="5" type="ordered locus">Gmet_2705</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a role in the regulation of phosphate uptake.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PhoU family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511756.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2705"/>
    <dbReference type="EnsemblBacteria" id="ABB32923">
        <property type="protein sequence ID" value="ABB32923"/>
        <property type="gene ID" value="Gmet_2705"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2705"/>
    <dbReference type="eggNOG" id="COG0704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078518_2_1_7"/>
    <dbReference type="OMA" id="WKHGIET"/>
    <dbReference type="OrthoDB" id="1648549at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030643">
        <property type="term" value="P:cellular phosphate ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045936">
        <property type="term" value="P:negative regulation of phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.220">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028366">
        <property type="entry name" value="P_transport_PhoU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038078">
        <property type="entry name" value="PhoU-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026022">
        <property type="entry name" value="PhoU_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42930">
        <property type="entry name" value="PTHR42930"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01895">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003107">
        <property type="entry name" value="PhoU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02135">
        <property type="entry name" value="phoU_full"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="PhoU" evidence="4">
        <location>
            <begin position="124"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR003107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="229" mass="26064" checksum="AD1B7AB5DF4EC712" modified="2005-11-22" version="1">MEREHFSRHFDEELNEIRNKLLEMGGKVEQMISDAMKSLVDRDSDLARRLIATDHQINHLELEIDEKCLQVLARRQPAARDLRFITLALKIVTDLERIGDQCTSVAKRVVELNEEPPLKPYIDLPRMSAAAGTMVKEALDAFVRGDAELAIKVCKEDAFVDGLNDQIQRELLTFMMEDPSSITRAMKLLYISKYMERIADHATNVAEMVIFMVKGKDIRHTAPPSGEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S58</accession>
    <name>Q39S58_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">lytS</name>
        <name evidence="14" type="ordered locus">Gmet_2698</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511763.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2698"/>
    <dbReference type="EnsemblBacteria" id="ABB32916">
        <property type="protein sequence ID" value="ABB32916"/>
        <property type="gene ID" value="Gmet_2698"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2698"/>
    <dbReference type="eggNOG" id="COG3275">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020473_3_3_7"/>
    <dbReference type="OMA" id="FRRHGDF"/>
    <dbReference type="OrthoDB" id="1031920at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010559">
        <property type="entry name" value="Sig_transdc_His_kin_internal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011620">
        <property type="entry name" value="Sig_transdc_His_kinase_LytS_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07694">
        <property type="entry name" value="5TM-5TMR_LYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13492">
        <property type="entry name" value="GAF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06580">
        <property type="entry name" value="His_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="460"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="576" mass="61552" checksum="6D256F09A15B4ADB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SC7</accession>
    <name>Q39SC7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511833.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2628"/>
    <dbReference type="EnsemblBacteria" id="ABB32847">
        <property type="protein sequence ID" value="ABB32847"/>
        <property type="gene ID" value="Gmet_2628"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2628"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_368724_0_0_7"/>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223056" evidence="2">
        <location>
            <begin position="25"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="3">
        <location>
            <begin position="305"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="756" mass="84394" checksum="07096D345AC04AC3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SF8</accession>
    <name>Q39SF8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ech-hydrogenase-related complex, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ehrL-1</name>
        <name evidence="3" type="ordered locus">Gmet_2597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511864.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2597"/>
    <dbReference type="EnsemblBacteria" id="ABB32816">
        <property type="protein sequence ID" value="ABB32816"/>
        <property type="gene ID" value="Gmet_2597"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2597"/>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_3_1_7"/>
    <dbReference type="OMA" id="WAYCMAL"/>
    <dbReference type="OrthoDB" id="473681at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_30kDa" evidence="1">
        <location>
            <begin position="50"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="263"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="2">
        <location>
            <begin position="440"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="506" mass="55253" checksum="EF9D225F5E780A2B" modified="2005-11-22" version="1">MKDSFRTIYNGASVPLAEIPPVDINEFLQGILDSVDRGWRIVSYFGIPAPSSTALVCILANKAEGRLAAARTETSDSHVPSLSSLITQVQLFEREIAEQCGLIFDGHPWFKPVRFHHSFVPGRDAWDRTADEPLRVGVMDYYQVAGDEVHEVAVGPVHAGIIEPGHFRFQCHGEEVFHLEISLGYQHRGIEAGLAGGPHPRTLQVMETAAGDTTIGHGQAYCMIMESLGGIKAPPRAEVLRGIALELERLANHTGDLGAIAGDVGYLPTSSFCGRIRGDFLNMTAVLCGSRFGRGLLVPGGTIFDLTPGLRDDLLKRLAEARRDLTNAIELLWSSPSVMGRLEGTGTLTREQALELGLVGPAARACGIKRDVRLDYPFGIYRMTHLPVATVFHGDVCARTMIRWLEAQKSMDFIEEQLRQLPGGGHRVATAPCAGGRLAVALTEGWRGEICHVAVTDDAGRFSRYKIVDPSFHNWQGLALALRGQQISDFPLCNKSFNLSYCGFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SH9</accession>
    <name>Q39SH9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CxxC_CxxC_SSSS superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513458.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2576"/>
    <dbReference type="EnsemblBacteria" id="ABB32795">
        <property type="protein sequence ID" value="ABB32795"/>
        <property type="gene ID" value="Gmet_2576"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2576"/>
    <dbReference type="eggNOG" id="COG5319">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113286_0_0_7"/>
    <dbReference type="OMA" id="CHTIFNF"/>
    <dbReference type="OrthoDB" id="1914830at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013429">
        <property type="entry name" value="Regulatory_FmdB_Zinc_ribbon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09723">
        <property type="entry name" value="Zn-ribbon_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00834">
        <property type="entry name" value="CxxC_CXXC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02605">
        <property type="entry name" value="CxxC_CxxC_SSSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CxxC_CXXC_SSSS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="162" mass="18583" checksum="2DF3A0D3FD2BF9D9" modified="2005-11-22" version="1">MPVYEFYCADCHTIFNFLSRRVDTEKRPDCPRCGRHELQRQVSRFAFSKGRTEEPLEGMPDLDEEKLERAMMGLAGEMEGMDENDPRQMARFMRKLQDATGMNLGSGFEEAMRRLEAGEDPEKIEAEMGDLLDADNPFAKEGIRGIKKRLAPPAHDDTLYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SU2</accession>
    <name>Q39SU2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain iron-sulfur cluster-binding oxidoreductase, DUF3641-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512443.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2457"/>
    <dbReference type="EnsemblBacteria" id="ABB32682">
        <property type="protein sequence ID" value="ABB32682"/>
        <property type="gene ID" value="Gmet_2457"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2457"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050695_0_0_7"/>
    <dbReference type="OMA" id="IYDCDFN"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024521">
        <property type="entry name" value="DUF3641"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026351">
        <property type="entry name" value="rSAM_SeCys"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43728">
        <property type="entry name" value="PTHR43728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12345">
        <property type="entry name" value="DUF3641"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04167">
        <property type="entry name" value="rSAM_SeCys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="DUF3641" evidence="6">
        <location>
            <begin position="180"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="318" mass="35268" checksum="24FC89FA0A381045" modified="2005-11-22" version="1">MVAVFKERLREIDPMYVTFEGLQTLQVNLGNICNQTCAHCHVNASPAGDRIMGPAVMEKIVGLLTRRPGITLDITGGCPEMNPHFRALVEKTRGHSPRRMVRSNLTIMTEPGMEWLPGFYRDQELVVIASLPCYQEENVERQRGPGVFARSIEALRILNGLGYGGTLELNLVYNPGGPLIPGSQRELEEAYKIELLTRYGIRFNNLYTIANAPIGRFREYLEAKGAYERYLAMLATRFNPEAARNIMCRTLVSVDWKGFLYNCDFNQAIGLPITSGSGEILKIDDLEEAATTGAELFLAQHCYCCTAGEGSSCTGALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T14</accession>
    <name>Q39T14_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2385</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514756.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2385"/>
    <dbReference type="EnsemblBacteria" id="ABB32610">
        <property type="protein sequence ID" value="ABB32610"/>
        <property type="gene ID" value="Gmet_2385"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2385"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_3_0_7"/>
    <dbReference type="OMA" id="PICPECM"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="PTHR22936"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="104"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="283" mass="30187" checksum="434A1BF333317DF8" modified="2005-11-22" version="1">MTTPERRSILCPNCGRLISRDEPSCPWCGTSHPGSWLKNNPLTRSVGSADQLVTIIITVNMVMYLVSLLISNHSPGHGGLFSALSPDQGSLLALGATGVVPIDRYGRFWSLLSANYLHGGPLHIFFNMMALRQLLPLVAQEYGTSRMLTIYTLGGVCGYVLSYLAGVGYTIGASAALCGLIGSLLYYGKSRGGVYGQAVFKEVWGWVVGLFFFGLIVPGINNWGHGGGVVGGIVLGFLLGYRERRAENLFHKFLAGGCILATAVALALGLLSAFITFAGRSLH</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T27</accession>
    <name>ENO_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enolase</fullName>
            <ecNumber evidence="1">4.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">2-phospho-D-glycerate hydro-lyase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-phosphoglycerate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">eno</name>
        <name type="ordered locus">Gmet_2372</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2-phosphoglycerate = H2O + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10164"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.2.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell surface</location>
        </subcellularLocation>
        <text evidence="1">Fractions of enolase are present in both the cytoplasm and on the cell surface. The export of enolase possibly depends on the covalent binding to the substrate; once secreted, it remains attached to the cell surface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the enolase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513248.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T27"/>
    <dbReference type="SMR" id="Q39T27"/>
    <dbReference type="STRING" id="269799.Gmet_2372"/>
    <dbReference type="PRIDE" id="Q39T27"/>
    <dbReference type="EnsemblBacteria" id="ABB32597">
        <property type="protein sequence ID" value="ABB32597"/>
        <property type="gene ID" value="Gmet_2372"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2372"/>
    <dbReference type="eggNOG" id="COG0148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031223_2_1_7"/>
    <dbReference type="OMA" id="EFMIIPV"/>
    <dbReference type="OrthoDB" id="533698at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="PTHR11902"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="SSF51604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="SSF54826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0324">Glycolysis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <feature type="chain" id="PRO_0000267039" description="Enolase">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent; in inhibited form" evidence="1">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="365"/>
            <end position="368"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="389"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00318"/>
        </source>
    </evidence>
    <sequence length="429" mass="46543" checksum="157576739889E806" modified="2005-11-22" version="1">MSEITDVYAREILDSRGNPTLEVEVFLESGVMGRAAVPSGASTGEREALELRDGDKSRYLGKGVLKAVDNVNNIIAEQIIGMEATDQIGIDQRMLDLDGTEYKSNLGANAILGVSLAVAKAAAEEVGLPLYQYIGGSNAKELPLPMMNILNGGAHADNNVDIQEFMIMPAGAKSFAEALRMGAEIFHALKGVLKGKGYNTAVGDEGGFAPNLKSNEEALEVIMDAIQKAGYKPGEEVLLALDVASSELFNDGVYTLENEAEPKKTPAQMVDFYENLVNKYPIVSIEDGMAENDWDGWKLLTDRLGKRIQIVGDDLFVTNPRILKEGIQKGIANSILIKLNQIGSLTETLDAIEMAKRAGYTCVISHRSGETEDTTLADLSVAVNAGQIKTGSLCRTDRVAKYNQLLRIEDELDTTALFRGKDVFYNIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T39</accession>
    <name>Q39T39_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Lysyl-tRNA synthetase</fullName>
            <shortName evidence="7">LysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 10" type="primary">lysS</name>
        <name evidence="10" type="ordered locus">Gmet_2360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7 8">
            <text>ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="7 8">Binds 3 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513260.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2360"/>
    <dbReference type="EnsemblBacteria" id="ABB32585">
        <property type="protein sequence ID" value="ABB32585"/>
        <property type="gene ID" value="Gmet_2360"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2360"/>
    <dbReference type="eggNOG" id="COG1190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008255_6_0_7"/>
    <dbReference type="OMA" id="EIFGEKC"/>
    <dbReference type="OrthoDB" id="63621at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AA_TRNA_LIGASE_II" evidence="9">
        <location>
            <begin position="174"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="491" mass="56364" checksum="3876933B7FF915CD" modified="2005-11-22" version="1">MEELSELLLQRRRKVDALWEAGINPYPNDYKPRHTSADVVAAYGKCEIIEEGADPFVVAGRIIARRSFGKAAFVQLQDRKGRIQLYVRKDTLGDEAYEAFESFDIGDIIGATGTPFRTKTGELSLNASEVRLLTKSFLPLPEKFHGLTDVETRYRQRYVDLIVNPEVREVFIKRSRIVNLIREFMVRHDFLEVETPMMQPIPGGATARPFVTHHNALDMELFLRIAPELYLKRLVVGGFERVFEINRNFRNEGISVRHNPEFTMMEFYQAYATFEDLMDFTEELLCHVTQEVLGTLDFTYQGVEISFQRPWKRLTVKEAILEYGDIDAKSLEDRDLAYAYARSIGLDLPTDVGYGKLITEIFEEVAEVKLIQPTFITAYPTEVSPLSRKSDKDPDIVDRFEFFCAGREMANAFSELNDPVDQKERFLGQVAQKAKGDEEAHYMDEDYIRALEYGMPPTAGEGIGIDRLVMLLTDSPSIRDVILFPQLRKEK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T44</accession>
    <name>LPXD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-3-O-acylglucosamine N-acyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.191</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lpxD</name>
        <name type="ordered locus">Gmet_2355</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] + a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine = a UDP-2-N,3-O-bis[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + H(+) + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:53836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:137748"/>
            <dbReference type="EC" id="2.3.1.191"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family. LpxD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.191" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513265.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T44"/>
    <dbReference type="SMR" id="Q39T44"/>
    <dbReference type="STRING" id="269799.Gmet_2355"/>
    <dbReference type="EnsemblBacteria" id="ABB32580">
        <property type="protein sequence ID" value="ABB32580"/>
        <property type="gene ID" value="Gmet_2355"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2355"/>
    <dbReference type="eggNOG" id="COG1044">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049865_0_0_7"/>
    <dbReference type="OMA" id="QIQIAHN"/>
    <dbReference type="OrthoDB" id="1602061at2"/>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03352">
        <property type="entry name" value="LbH_LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00523">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007691">
        <property type="entry name" value="LpxD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020573">
        <property type="entry name" value="UDP_GlcNAc_AcTrfase_non-rep"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43378">
        <property type="entry name" value="PTHR43378"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04613">
        <property type="entry name" value="LpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01853">
        <property type="entry name" value="lipid_A_lpxD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000264377" description="UDP-3-O-acylglucosamine N-acyltransferase">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00523"/>
        </source>
    </evidence>
    <sequence length="345" mass="35942" checksum="42968F41E6276B7C" modified="2005-11-22" version="1">MAVSRTLRELAEYLGGTVAGDESKTISGVASLDDAADHQITFLANPRYAPKVATTGAGAVVLPPGGERHGRNAIHVANPYLAFAKLLTLFHVAPRKPQGVMEGALVGHNVAMGSDVTIYPGAFVGDGVTLGDRVTIFPGVVIYEGVTLGSDVTLHSNVVVYQGCRIGNRVTIHAGTIIGSDGFGYAPDGDGFYKIPQLGIVVIEDDVEVGANTTIDRAALAATRIGRGTKIDNLVMIAHNCVIGENCTIVSQVGISGSTKLGRRVTLAGQVGVAGHLEIGDNSMVGAKSGIPGNIPAGSMVSGIPAFNHRDWLRASAVVPKLPELRKTIAELEKRVRELEEKQGA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T82</accession>
    <name>RNC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease 3</fullName>
            <ecNumber evidence="1">3.1.26.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribonuclease III</fullName>
            <shortName evidence="1">RNase III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnc</name>
        <name type="ordered locus">Gmet_2317</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease III family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513303.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T82"/>
    <dbReference type="SMR" id="Q39T82"/>
    <dbReference type="STRING" id="269799.Gmet_2317"/>
    <dbReference type="PRIDE" id="Q39T82"/>
    <dbReference type="EnsemblBacteria" id="ABB32542">
        <property type="protein sequence ID" value="ABB32542"/>
        <property type="gene ID" value="Gmet_2317"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2317"/>
    <dbReference type="eggNOG" id="COG0571">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000907_1_3_7"/>
    <dbReference type="OMA" id="LTHKSCK"/>
    <dbReference type="OrthoDB" id="1890943at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00104">
        <property type="entry name" value="RNase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011907">
        <property type="entry name" value="RNase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="PTHR11207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="SSF69065"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02191">
        <property type="entry name" value="RNaseIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0507">mRNA processing</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000228534" description="Ribonuclease 3">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="1">
        <location>
            <begin position="16"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="1">
        <location>
            <begin position="173"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00104"/>
        </source>
    </evidence>
    <sequence length="246" mass="26723" checksum="3C5517774B3D9A44" modified="2005-11-22" version="1">MGERGVEDKSAVQESATELEAGIGYRFVNRQFLAEALTHRSWVNERRGEEGIRDNERLEFLGDAVLGLLVGKMLFARFPQSREGVLARMKASLVGEETLAALASARGLGRHLLLGRGEERSGGRERRSLLANTYEALLAAVYLDGGLGPVERIVEQDFSPLLAGIASGATGRDFKTEFQEMVQTRFGTAPTYELIATDGPPHDRRFTVIAMVAGKRMGEGAGRSKKEAEQAAARQVLARFAAEGEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T84</accession>
    <name>ERA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GTPase Era</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">era</name>
        <name type="ordered locus">Gmet_2315</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513305.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T84"/>
    <dbReference type="SMR" id="Q39T84"/>
    <dbReference type="STRING" id="269799.Gmet_2315"/>
    <dbReference type="EnsemblBacteria" id="ABB32540">
        <property type="protein sequence ID" value="ABB32540"/>
        <property type="gene ID" value="Gmet_2315"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2315"/>
    <dbReference type="eggNOG" id="COG1159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038009_1_0_7"/>
    <dbReference type="OMA" id="WAEVDVI"/>
    <dbReference type="OrthoDB" id="984717at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04163">
        <property type="entry name" value="Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00367">
        <property type="entry name" value="GTPase_Era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030388">
        <property type="entry name" value="G_ERA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005662">
        <property type="entry name" value="GTP-bd_Era"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42698">
        <property type="entry name" value="PTHR42698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00436">
        <property type="entry name" value="era"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51713">
        <property type="entry name" value="G_ERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0690">Ribosome biogenesis</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_1000205541" description="GTPase Era">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Era-type G" evidence="2">
        <location>
            <begin position="7"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="205"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="G1" evidence="2">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="G2" evidence="2">
        <location>
            <begin position="41"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="G3" evidence="2">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="G4" evidence="2">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="G5" evidence="2">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="62"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01050"/>
        </source>
    </evidence>
    <sequence length="298" mass="33223" checksum="4E9FC3B6FF9F4F07" modified="2005-11-22" version="1">MSDNPFRSGFVSIIGRPNVGKSTLLNRILGEKIVITSDKPQTTRNRIQGIHNVPGAQIVFIDTPGIHQARSRLNKYMVEVALSAIREVDLVLFLVEANQKPGEQEQEIIDVLAGATAPVFLVINKVDLTEKGAVLERIAAYKDRYPFREIVPISAGTGDGVDHLVELVRKALPQGPVYFPDDILTDVPERFIAAEIIREKVFRMTRDEVPYATAVEVDSFKEREDGGLVSIAATITVERDSQKGIIIGKKGAMLKKIGSAARVEIEKLLNTKVFLELFVRVRKDWSEDERMLKELGYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TI9</accession>
    <name>Q39TI9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">(R)-methylmalonyl-CoA mutase, adenosylcobamide-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365964.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2208"/>
    <dbReference type="EnsemblBacteria" id="ABB32435">
        <property type="protein sequence ID" value="ABB32435"/>
        <property type="gene ID" value="Gmet_2208"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2208"/>
    <dbReference type="eggNOG" id="COG2185">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_128233_0_0_7"/>
    <dbReference type="OMA" id="VECVTAL"/>
    <dbReference type="OrthoDB" id="2222204at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006159">
        <property type="entry name" value="Acid_CoA_mut_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00640">
        <property type="entry name" value="acid_CoA_mut_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="5"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="135" mass="14767" checksum="8BFC34B982BC23DF" modified="2005-11-22" version="1">MSNQHIKVLLAKKKIDVHGRASKLIARELRDAGMEVVYFRFGTVDDIVTAAIQEDVNVIALSIMTSGHMLIAKKLIPALKANGMTDVLVIIGGIIPEVDFEELEKIGIHKCFISGLPGETVAEYIKENVGKVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TN3</accession>
    <name>Q39TN3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2162"/>
    <dbReference type="EnsemblBacteria" id="ABB32391">
        <property type="protein sequence ID" value="ABB32391"/>
        <property type="gene ID" value="Gmet_2162"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2162"/>
    <dbReference type="HOGENOM" id="CLU_2436605_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223115" evidence="2">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="90" mass="9729" checksum="BEE3C66D9A3591BB" modified="2005-11-22" version="1">MQSTQGGKEVRIMRKLPALASAIILSGLMAASLHAAQNPGSGNPQKQQAQVKRNSAPAPKKAVLSKRNRAKIEVEEMKKIKQQLQKDGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TN6</accession>
    <name>Q39TN6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sensor histidine kinase, PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2159"/>
    <dbReference type="EnsemblBacteria" id="ABB32388">
        <property type="protein sequence ID" value="ABB32388"/>
        <property type="gene ID" value="Gmet_2159"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2159"/>
    <dbReference type="eggNOG" id="COG3284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_0_7"/>
    <dbReference type="OMA" id="MIMSAVI"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011712">
        <property type="entry name" value="Sig_transdc_His_kin_sub3_dim/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07730">
        <property type="entry name" value="HisKA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="51"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="2">
        <location>
            <begin position="231"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="439" mass="48967" checksum="428CA4E606D1775A" modified="2005-11-22" version="1">MTEPLPPSSSAFSPRTEKEIEMLLLEIEAQKNVLELQNAKLVDAMAEKEHVLQQFNRLFDQAPVGGVILGQDGIIRTVNHIAAHMLGEERSRLVGRPLEQFLSEGSRPVFAEFLRNMMSACKASCELEQPIGGNPSLIRFEGACDTCGDECRVAMIDITGRHIPEEERAPGAGGHRKLRWYELSGKPPPPDREDSREIERSKREEGLVDSLKKQRRLSFHLMSAREEERTAVAREIHEELGQMLAALQLNVSLVTKEYLDHAKLVARTQAMEQLITSSIMTVNRISSELRPVMLDILGLADAIEWQAKEFEKKSGIRCKTTILLAEKKVDRDVSTAVYRIVQEALSNVARHATADHVRVTLVEKVGRVTLSVSDNGRGITEREKNNPQSLGIAGMRERAEAFGGRLRICGSSRQGTTVVARIPLAREGDVDEHQDTCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TP7</accession>
    <name>Q39TP7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513057.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2148"/>
    <dbReference type="EnsemblBacteria" id="ABB32377">
        <property type="protein sequence ID" value="ABB32377"/>
        <property type="gene ID" value="Gmet_2148"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2148"/>
    <dbReference type="eggNOG" id="ENOG50338CY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651747_0_0_7"/>
    <dbReference type="OMA" id="RFAAYYF"/>
    <dbReference type="OrthoDB" id="837523at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223117" evidence="1">
        <location>
            <begin position="22"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="447" mass="47323" checksum="FB7E48237821B19F" modified="2005-11-22" version="1">MKNKGLTVGISALLLAAPAMAEELPQTVAPVYNCDFQPNCEVAPGIYGKMASPVTSKFNLSIGGYVKLDYAYNSVNLGSNGALGTLQRGIPKSSSPAGQEDQSIFTARQSRIWLKVGGPTFLGAKTNAIIETDFYGGGGASNETATMRLRLANASLDWANTQLVLGQAYDIFGPATASTVDFGQAAMTGAPNNPRVPQIRVTHRLNLNDKNALRLVLGVQNPVQDSNLQGASGDSWGAKVNVAGQAMLISKVLGVAPGYYGMSMNSLTAGFFGLYGNQDVAGNKDSVDSWGYGFYTFVPLLPSKDGKNRAMTASFEGQAYMAANMYTIGATAGTVVGAAGDKKPAKGYGIYSQLIFYPTQDLGITAGYARRNAYNYASYRGIDNFEKSNSAIYANVTYDLNAALRFAVEYQNINTQYGNVTNGTGNLAGLATSGTANIGRFAAYYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U07</accession>
    <name>Q39U07_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">N-acylhomoserine lactone synthetase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512913.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2038"/>
    <dbReference type="EnsemblBacteria" id="ABB32267">
        <property type="protein sequence ID" value="ABB32267"/>
        <property type="gene ID" value="Gmet_2038"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2038"/>
    <dbReference type="eggNOG" id="COG3916">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072758_0_0_7"/>
    <dbReference type="OMA" id="GITHWYA"/>
    <dbReference type="OrthoDB" id="1725271at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022484">
        <property type="entry name" value="PEP-CTERM/exosrtase_acylTfrase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03694">
        <property type="entry name" value="exosort_acyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="233" mass="27341" checksum="3F2A7D166897B46C" modified="2005-11-22" version="1">MIPFTFECVDKTSNKYDETMEEVYRLRFKVYCEEWRFEDPKDYPDGMERNEYDDFSEHFIIRCTEDESIVGTARIILPNALGYPMIQHCEIVSEMHEHALRGVENVKIGEVSRLAISKEYRKRIEDDALVGYDATLPSGAGVVHDLRKCNYVHEFYKFLLLSSVNMGLSHWYVAMKRGLYILLKRVGMIYHPVGPEVDYHGLRTPYLGNLQELRLGMERKDPDCFKFIESNML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U53</accession>
    <name>Q39U53_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1992</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512958.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1992"/>
    <dbReference type="EnsemblBacteria" id="ABB32221">
        <property type="protein sequence ID" value="ABB32221"/>
        <property type="gene ID" value="Gmet_1992"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1992"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="CATHQNL"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014264">
        <property type="entry name" value="Sig_transdc_resp-reg_PEP-CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02915">
        <property type="entry name" value="PEP_resp_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="3"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="147"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="455" mass="50769" checksum="0B82201FA5DB1471" modified="2005-11-22" version="1">MEKLLIVDDNEDIRRQLRWGIGKEYSLHLAADGTEALELFRKHRPQVVTLDLGLPPHEDSSEEGFRCLGEMLRIAPDAKVIVITGNEGKENAVKAVQMGAYDFYQKPIDLNELKVIIKRAFHLQTLEDENRRLQSALGGSGPDVKGIIGQCAEMQQVFSTIRKVATSDISVLIHGESGTGKELVARAIHAQSLRKDGPFIPINCGAIPENLLESELFGHEKGAFTGAMARVQGKVEYAHKGTLFLDEIGELPLNLQVKLLRFLQEKAIQRVGGREDISIDSRIIAATNVDIVRAMEEGRFREDLYYRIGVVTVTLPPLRNRGDDVMLLANFFLKRCVNEFKKKIKGFSETSREYIENYGWPGNVRELENKVQRAVLMASGAVIEPDDLGFTERPSARKAGIGEVTTLREAREQVEREMIRGAITNSKGNIAKAAEELGISRPTLYDLMRKHGINA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U64</accession>
    <name>Q39U64_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein MgtC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1981</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MgtC/SapB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365895.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1981"/>
    <dbReference type="EnsemblBacteria" id="ABB32210">
        <property type="protein sequence ID" value="ABB32210"/>
        <property type="gene ID" value="Gmet_1981"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1981"/>
    <dbReference type="eggNOG" id="COG1285">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079292_0_1_7"/>
    <dbReference type="OMA" id="SYHGRPA"/>
    <dbReference type="OrthoDB" id="2022224at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003416">
        <property type="entry name" value="MgtC/SapB/SrpB/YhiD_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33778">
        <property type="entry name" value="PTHR33778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02308">
        <property type="entry name" value="MgtC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01837">
        <property type="entry name" value="MGTCSAPBPROT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="225" mass="24122" checksum="9F7ADA8E127CFEC1" modified="2005-11-22" version="1">MEFNLYMIGRLLLASLLGGLIGLEREIHGRPAGFRTHLLVSLGSCLFVVASIEFYRLYGNFSGVGPLGVDPGRVAAQVVTGIGFLGAGAILREGSSIRGLTTAACLWIAAAIGLSCGAGLYTVSLAVTAISLITLLCLKRVESVLKRDSYYSVKVWSDDMRGLSDRIEQVLKAGGLEILDVNVEKDIDSARMYFEFDVKFSTRGAKGAIVESLVSVDGVRKVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UB2</accession>
    <name>Q39UB2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DnaJ-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511910.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1933"/>
    <dbReference type="EnsemblBacteria" id="ABB32162">
        <property type="protein sequence ID" value="ABB32162"/>
        <property type="gene ID" value="Gmet_1933"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1933"/>
    <dbReference type="eggNOG" id="COG2214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177536_0_0_7"/>
    <dbReference type="OMA" id="DEFYEQN"/>
    <dbReference type="OrthoDB" id="1948818at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="8"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="97" mass="11540" checksum="8A2A30395B57B847" modified="2005-11-22" version="1">MRYANLVRALEIFGLPDRVTLREIKARHRELVRRHHPDSAGEEGDAEQIRLVNAAYGILREYAENYRFSFAEEEFYEQNPEERLRMQFANTPLWGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UD8</accession>
    <name>Q39UD8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix-turn-helix transcriptional regulator, Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511937.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1907"/>
    <dbReference type="EnsemblBacteria" id="ABB32136">
        <property type="protein sequence ID" value="ABB32136"/>
        <property type="gene ID" value="Gmet_1907"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1907"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_1_1_7"/>
    <dbReference type="OMA" id="GPIAMVP"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="153" mass="17125" checksum="70822BA4A8BC2A76" modified="2005-11-22" version="1">MISKKTKYALKALLYLAREYDRGPILIADLAREERIPKKFLELILLALKNAGVLQSKKGKGGGYYLAHPPREITMGKVIRTLEGPLAPVPCVSETAYARCEECDDEWSCGIRLVMKDVRDAMAQILDNATLAAVLERIEQEKQKKDGALFYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UL9</accession>
    <name>Q39UL9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Indolepyruvate:ferredoxin oxidoreductase, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">iorB-1</name>
        <name evidence="3" type="ordered locus">Gmet_1826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512019.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1826"/>
    <dbReference type="EnsemblBacteria" id="ABB32055">
        <property type="protein sequence ID" value="ABB32055"/>
        <property type="gene ID" value="Gmet_1826"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1826"/>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_1_1_7"/>
    <dbReference type="OMA" id="HGMSQRF"/>
    <dbReference type="OrthoDB" id="1603697at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="14"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="192" mass="20631" checksum="A9AC291D87E328B4" modified="2005-11-22" version="1">MSDTITNILLVGVGGQGILLASEVLSETFMQAGYDVKKSEIHGMSQRGGSVVSHVRYGREVHSPIIPEGEGDILFGFEILETYRSLPLMKNGGTVIANDLRIPPPSVLLGQETYPDDLPGKIAAMFPDSLLVDGQKLAAEAGNVRAANTVLLGAVSKRLDIPDECWIKALEKMIPPKALKVNHVAFQLGRSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-08-21" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UR5</accession>
    <name>PPNP_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyrimidine/purine nucleoside phosphorylase</fullName>
            <ecNumber evidence="1">2.4.2.1</ecNumber>
            <ecNumber evidence="1">2.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Adenosine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cytidine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Guanosine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Inosine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Uridine phosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Xanthosine phosphorylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ppnP</name>
        <name type="ordered locus">Gmet_1778</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a purine D-ribonucleoside + phosphate = a purine nucleobase + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19805"/>
            <dbReference type="ChEBI" id="CHEBI:26386"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="ChEBI" id="CHEBI:142355"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine + phosphate = alpha-D-ribose 1-phosphate + cytosine</text>
            <dbReference type="Rhea" id="RHEA:52540"/>
            <dbReference type="ChEBI" id="CHEBI:16040"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine</text>
            <dbReference type="Rhea" id="RHEA:13233"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:16750"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + thymidine = 2-deoxy-alpha-D-ribose 1-phosphate + thymine</text>
            <dbReference type="Rhea" id="RHEA:16037"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:17821"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57259"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + uridine = alpha-D-ribose 1-phosphate + uracil</text>
            <dbReference type="Rhea" id="RHEA:24388"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17568"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + xanthosine = alpha-D-ribose 1-phosphate + xanthine</text>
            <dbReference type="Rhea" id="RHEA:27638"/>
            <dbReference type="ChEBI" id="CHEBI:17712"/>
            <dbReference type="ChEBI" id="CHEBI:18107"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the nucleoside phosphorylase PpnP family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.1" evidence="1"/>
    <dbReference type="EC" id="2.4.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513325.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UR5"/>
    <dbReference type="SMR" id="Q39UR5"/>
    <dbReference type="STRING" id="269799.Gmet_1778"/>
    <dbReference type="EnsemblBacteria" id="ABB32009">
        <property type="protein sequence ID" value="ABB32009"/>
        <property type="gene ID" value="Gmet_1778"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1778"/>
    <dbReference type="eggNOG" id="COG3123">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157874_1_0_7"/>
    <dbReference type="OMA" id="YHYICHF"/>
    <dbReference type="OrthoDB" id="1937865at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047975">
        <property type="term" value="F:guanosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004731">
        <property type="term" value="F:purine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016154">
        <property type="term" value="F:pyrimidine-nucleoside phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009032">
        <property type="term" value="F:thymidine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004850">
        <property type="term" value="F:uridine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01537">
        <property type="entry name" value="Nucleos_phosphorylase_PpnP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009664">
        <property type="entry name" value="Ppnp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36540">
        <property type="entry name" value="PTHR36540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06865">
        <property type="entry name" value="Ppnp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000298696" description="Pyrimidine/purine nucleoside phosphorylase">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01537"/>
        </source>
    </evidence>
    <sequence length="104" mass="11307" checksum="7948986CDA19D2BE" modified="2005-11-22" version="1">MSEFINVTVVREANVFFNGGVVSRTVIFPDGTKKTLGIMQPGEYTFNTGAPEIMEILTGELDLKLPGSDLWDRIGGGESFEVPANSSFTMKVLSLTDYCCSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UZ1</accession>
    <name>Q39UZ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1702</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514152.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31933">
        <property type="protein sequence ID" value="ABB31933"/>
        <property type="gene ID" value="Gmet_1702"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1702"/>
    <dbReference type="HOGENOM" id="CLU_1364573_0_0_7"/>
    <dbReference type="OrthoDB" id="1700773at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="200" mass="22672" checksum="50901FD302B91D38" modified="2005-11-22" version="1">MTSTHSILLGRNLKRLLLLLPLMMMLAACGPSHMVKKEEPLDIMTVKPKTGKAALVIARTTSFGGAVNFFTHLDKKFIGVTKGKGCFIKTDIEPGLQYLITRTESLETGKIQFEPDTVYYVQQTPRMGWWVARVTLTPVTAEHLASEIGNDGCTFYELDPTDPYEDLSDHEYKEAVTDYEREITEGYHKEFTEYKGRKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V80</accession>
    <name>Q39V80_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-(Acyl carrier protein) ligase, acyl carrier, [acyl-]glycerolphosphate acyltransferase fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511451.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1613"/>
    <dbReference type="DNASU" id="3739352"/>
    <dbReference type="EnsemblBacteria" id="ABB31844">
        <property type="protein sequence ID" value="ABB31844"/>
        <property type="gene ID" value="Gmet_1613"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1613"/>
    <dbReference type="eggNOG" id="COG0204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_45_1_7"/>
    <dbReference type="OMA" id="KPSAIME"/>
    <dbReference type="OrthoDB" id="164380at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="3">
        <location>
            <begin position="522"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="824" mass="91708" checksum="5277C9DBBB1230FA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VC0</accession>
    <name>Q39VC0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1572</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511493.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1572"/>
    <dbReference type="EnsemblBacteria" id="ABB31804">
        <property type="protein sequence ID" value="ABB31804"/>
        <property type="gene ID" value="Gmet_1572"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1572"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_7"/>
    <dbReference type="OMA" id="TDGHARI"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="259" mass="27568" checksum="E5AEE751679DF061" modified="2005-11-22" version="1">MSAKQIAVRHDDAIAVVSLARPESRNVLSRDLVLGLLSTFTSLKDDGRVKGIVVTGEGKSFCAGADISEMARMSPAEASSFAELGQRLMFAVERVGKPVVAAVNGHAFGGGLELALACDFIVAAESAVFAAPEVLLGVMPGFGGTQRLPRLIGKSRAKEMIFTGERINAAKAHSIGLVNRVVSDERLLAETVSLVKNICNRGLLSLRVAKEVIDAGAGIDLATACLMERDAFALCFSTDDQKEGMRAFMEKREPRFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VG4</accession>
    <name>Q39VG4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">etfA-5</name>
        <name evidence="4" type="ordered locus">Gmet_1526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2019" name="J. Bacteriol." volume="201" first="0" last="0">
            <title>Structural and Functional Characterization of an Electron Transfer Flavoprotein Involved in Toluene Degradation in Strictly Anaerobic Bacteria.</title>
            <authorList>
                <person name="Vogt M.S."/>
                <person name="Schuhle K."/>
                <person name="Kolzer S."/>
                <person name="Peschke P."/>
                <person name="Chowdhury N.P."/>
                <person name="Kleinsorge D."/>
                <person name="Buckel W."/>
                <person name="Essen L.O."/>
                <person name="Heider J."/>
            </authorList>
            <dbReference type="PubMed" id="31405915"/>
            <dbReference type="DOI" id="10.1128/JB.00326-19"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 1-294</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511541.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OW0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="A=1-294"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OW0"/>
    <dbReference type="SMR" id="Q39VG4"/>
    <dbReference type="STRING" id="269799.Gmet_1526"/>
    <dbReference type="EnsemblBacteria" id="ABB31760">
        <property type="protein sequence ID" value="ABB31760"/>
        <property type="gene ID" value="Gmet_1526"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1526"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_7"/>
    <dbReference type="OMA" id="WRPYAEQ"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="2"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="5OW0"/>
        </source>
    </evidence>
    <sequence length="295" mass="30782" checksum="F57F3689C4905CE6" modified="2005-11-22" version="1">MKTLIIETANAKILGELVTVSRLFGQAPDVVVLGSGELQGSYGKAYRLSDTLGANLGSSLSDLIKRERYELILLSTTAIGSGLAGPLAVSLGAPILSEVTAISPDLTIERSLYGSKAVARYKLESGPLVLTIKRKYFEAATLEGTTATEELPVGPQKITLLEEIEEERTGIPLEDAEVVVTGGRGIGSGDNFSILKEIAGMLNGAVGASRGAVDEGWMPPGAQIGQTGKIVAPTVYFAVGVSGASQHLAGISNAKCVIAINKDNEANIFKRARFGIVGDYKKAVPALINALKENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VI1</accession>
    <name>Q39VI1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Misacylated tRNA(Pro) deacylase, YbaK/ProX family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511558.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1509"/>
    <dbReference type="EnsemblBacteria" id="ABB31743">
        <property type="protein sequence ID" value="ABB31743"/>
        <property type="gene ID" value="Gmet_1509"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1509"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119898_0_0_7"/>
    <dbReference type="OMA" id="VTGRVNY"/>
    <dbReference type="OrthoDB" id="1792474at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="1">
        <location>
            <begin position="28"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="162" mass="17498" checksum="C9144E8F271733B5" modified="2005-11-22" version="1">MDFVAGEAFSAFMETVEKSGIPFVLHAHAATRTVEEAGRNLTFDVSRIVKTVAFRIRSGGLVLAVLRGTRRVDYPNLAALIGVSRRDLAPLSPEEVREFLGVEPGSVSPMSLWENATALIDDEVLTILPTVYCGIGRPDRTLEVTPADLVRLAGGRTGGFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VI2</accession>
    <name>Q39VI2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur cluster-binding flavodoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1508</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511559.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1508"/>
    <dbReference type="EnsemblBacteria" id="ABB31742">
        <property type="protein sequence ID" value="ABB31742"/>
        <property type="gene ID" value="Gmet_1508"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1508"/>
    <dbReference type="eggNOG" id="COG0426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069541_0_0_7"/>
    <dbReference type="OMA" id="CIKCQAC"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="266" mass="28539" checksum="101EDEB141670DA5" modified="2005-11-22" version="1">MAINSTRLIYFSPTQTTRKVVEGIAKGVGVDDVEHLDLTPPGAAVQRQVDTRDGLVIIGAPVYAGRLPAEAAARLQRLMANGTPAVIVVVYGNRAYEDALLELWDLALEAGFKPVAAGAFIGEHSYSTVATPIAVGRPDTEDLRAARDFGRMIREKMGMMEDFGDISLLQVPGNFPYRESGLFSSISPVTQEAACTKCVRCVSACPTGAIVLQDKVATDPSICIRCCACIKGCSAGARTMTDPHVRQVAEQLSSSCRSRKEPEMFL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-09-19" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VS8</accession>
    <name>IF3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infC</name>
        <name type="ordered locus">Gmet_1412</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31646.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365824.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VS8"/>
    <dbReference type="SMR" id="Q39VS8"/>
    <dbReference type="STRING" id="269799.Gmet_1412"/>
    <dbReference type="EnsemblBacteria" id="ABB31646">
        <property type="protein sequence ID" value="ABB31646"/>
        <property type="gene ID" value="Gmet_1412"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1412"/>
    <dbReference type="eggNOG" id="COG0290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054919_3_2_7"/>
    <dbReference type="OMA" id="RNMIMFL"/>
    <dbReference type="OrthoDB" id="1760144at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00080">
        <property type="entry name" value="IF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036788">
        <property type="entry name" value="T_IF-3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036787">
        <property type="entry name" value="T_IF-3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019813">
        <property type="entry name" value="Translation_initiation_fac3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001288">
        <property type="entry name" value="Translation_initiation_fac_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019815">
        <property type="entry name" value="Translation_initiation_fac_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019814">
        <property type="entry name" value="Translation_initiation_fac_3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10938">
        <property type="entry name" value="PTHR10938"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00707">
        <property type="entry name" value="IF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05198">
        <property type="entry name" value="IF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54364">
        <property type="entry name" value="SSF54364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55200">
        <property type="entry name" value="SSF55200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00168">
        <property type="entry name" value="infC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00938">
        <property type="entry name" value="IF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000250214" description="Translation initiation factor IF-3">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00080"/>
        </source>
    </evidence>
    <sequence length="172" mass="19619" checksum="501E44EA2266F96E" modified="2006-09-19" version="2">MAKPTVNVNQAIRAREIRVVGANSEQLGIMPLNEALALAESQQLDLVEVSPTAVPPVCRIMDYGKFKYQQSKKLQEAKKKQSHVVVKEVKLRPKTDEHDLQFKIKHVRRFIEEGNKAKVTLVFRGREITHMEFGVRALERVASEIEDIAVIEMKPKMEGRSMFMIVAPKVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VW6</accession>
    <name>Q39VW6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Multidrug resistance efflux pump, RND family, inner membrane protein EmrB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513134.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1374"/>
    <dbReference type="EnsemblBacteria" id="ABB31608">
        <property type="protein sequence ID" value="ABB31608"/>
        <property type="gene ID" value="Gmet_1374"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1374"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000960_28_0_7"/>
    <dbReference type="OMA" id="IWGMVIG"/>
    <dbReference type="OrthoDB" id="1108236at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004638">
        <property type="entry name" value="EmrB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00711">
        <property type="entry name" value="efflux_EmrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="200"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="486"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="13"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="517" mass="56188" checksum="7E8DBB95490E2341" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VY5</accession>
    <name>PYRF_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">OMP decarboxylase</fullName>
            <shortName evidence="1">OMPDCase</shortName>
            <shortName evidence="1">OMPdecase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrF</name>
        <name type="ordered locus">Gmet_1355</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + orotidine 5'-phosphate = CO2 + UMP</text>
            <dbReference type="Rhea" id="RHEA:11596"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="EC" id="4.1.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OMP decarboxylase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513153.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VY5"/>
    <dbReference type="SMR" id="Q39VY5"/>
    <dbReference type="STRING" id="269799.Gmet_1355"/>
    <dbReference type="EnsemblBacteria" id="ABB31589">
        <property type="protein sequence ID" value="ABB31589"/>
        <property type="gene ID" value="Gmet_1355"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1355"/>
    <dbReference type="eggNOG" id="COG0284">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067069_0_0_7"/>
    <dbReference type="OMA" id="NFKIFLD"/>
    <dbReference type="OrthoDB" id="1150446at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01200_B">
        <property type="entry name" value="OMPdecase_type1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="PTHR32119:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01740">
        <property type="entry name" value="pyrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000241861" description="Orotidine 5'-phosphate decarboxylase">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01200"/>
        </source>
    </evidence>
    <sequence length="239" mass="25631" checksum="E1939F4F1E2B3C1A" modified="2005-11-22" version="1">MTRDQAREKVIFALDTGEFAHVQYWAETLSDKVGMYKIGKQLFTACGPAAVRMIQKFGGEVFLDLKFHDIPNTVAMASVEAARMGVKLFNLHALGGYEMMAKTVEALDKEFKGGDRAKVLAVTILTSSTEETLKDLGIEHTVPDMVVRLATLARKAGIDGVVASPREIPLIREACGSDFLIVTPGVRPSFAALNDQKRVMTPAEAVKAGSDYLVIGRPIGDAPDPAAAAELILGEIVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W65</accession>
    <name>Q39W65_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512094.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1273"/>
    <dbReference type="EnsemblBacteria" id="ABB31509">
        <property type="protein sequence ID" value="ABB31509"/>
        <property type="gene ID" value="Gmet_1273"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1273"/>
    <dbReference type="eggNOG" id="COG2324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086312_0_0_7"/>
    <dbReference type="OMA" id="FGMPYQN"/>
    <dbReference type="OrthoDB" id="1515153at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007354">
        <property type="entry name" value="CruF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39419">
        <property type="entry name" value="PTHR39419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04240">
        <property type="entry name" value="Caroten_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="289" mass="32828" checksum="C918B9F8BA988E5E" modified="2005-11-22" version="1">MEDVFRIAAGTVTMRPYVFAFFAAYLVAAVPHLGWRKIALFTVVGYLTAFLSEFSSITTGIPYGWYYYIDVTRDRELWIAGVPFFDSLSYVFLTYCSYATAIFVVAPIKAWRWDLVTLETRSLRNSFAVLFLGSLFQVFLDIIIDPVALQGSRWFLGQIYGYREVGAHFGVPLSNYLGWWLVSFMLVFALQRIDAWGGSSRSERPAGVANPPLRALYGPILYVSVLVFNLSVTLWIGERLMALTGLFIIIPAMAISTVTIIRRTNRYRKEELAEHLRDFPWSVASARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WA7</accession>
    <name>Q39WA7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365784.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1231"/>
    <dbReference type="EnsemblBacteria" id="ABB31467">
        <property type="protein sequence ID" value="ABB31467"/>
        <property type="gene ID" value="Gmet_1231"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1231"/>
    <dbReference type="eggNOG" id="ENOG5033IU1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_191399_0_0_7"/>
    <dbReference type="OMA" id="DTWVICF"/>
    <dbReference type="OrthoDB" id="1980697at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="85" mass="10286" checksum="F0427A10A3A8DE28" modified="2005-11-22" version="1">MWMKLRVALFKRLRLSESWVIFFILGFVMMNYPFIQIFNKPYRIFSIPLLYLYFVGGWALSIVVIYLFTKAIDQPEDEQDEGDHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WD7</accession>
    <name>Q39WD7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512170.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1200"/>
    <dbReference type="EnsemblBacteria" id="ABB31437">
        <property type="protein sequence ID" value="ABB31437"/>
        <property type="gene ID" value="Gmet_1200"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1200"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_237995_0_0_7"/>
    <dbReference type="OMA" id="AYQCYGD"/>
    <dbReference type="OrthoDB" id="259213at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024983">
        <property type="entry name" value="CHAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12770">
        <property type="entry name" value="CHAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="SSF52129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CHAT" evidence="2">
        <location>
            <begin position="1170"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="domain" description="TIR" evidence="3">
        <location>
            <begin position="2032"/>
            <end position="2113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1843"/>
            <end position="1878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1852"/>
            <end position="1874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="2159" mass="234769" checksum="F8D5960844837844" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WD9</accession>
    <name>Q39WD9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1198</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512172.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1198"/>
    <dbReference type="EnsemblBacteria" id="ABB31435">
        <property type="protein sequence ID" value="ABB31435"/>
        <property type="gene ID" value="Gmet_1198"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1198"/>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078227_0_0_7"/>
    <dbReference type="OrthoDB" id="1456527at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021556">
        <property type="entry name" value="DUF2950"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11453">
        <property type="entry name" value="DUF2950"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="325" mass="35653" checksum="B963ECE6CBE72720" modified="2005-11-22" version="1">MKVSASNHKGGTGWVMWACVVAVAMIFSVISTPSFAAQTRQKKFATPDNAVKALVAAVREGNERDLTLILGPGSKDLISSGDEVADKTDREKFLAAYDRMNSLERKSATVMVLHVGPDNWPMPIPIVKKGGKWAFNIGTGKKEILKRRIGRNELHVIDVLDAYVDAQQEYAGKDCRGGGKVEFAQKLISSEGKRDGLYWEAKEGEPESPLGPLVARAAKEGYAKESNLSPFHGYYFKILKGQGKHAAGGAYQYVVKERMILGFALVAYPAEYGNSGVMTFIVNQAGTVYEKNLGKNTRRLAEAMELFDPDKTWKPVKTGETSKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WI7</accession>
    <name>Q39WI7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513414.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1149"/>
    <dbReference type="EnsemblBacteria" id="ABB31387">
        <property type="protein sequence ID" value="ABB31387"/>
        <property type="gene ID" value="Gmet_1149"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1149"/>
    <dbReference type="eggNOG" id="ENOG5032YVY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142668_4_0_7"/>
    <dbReference type="OMA" id="EARVEYH"/>
    <dbReference type="OrthoDB" id="2022157at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="95" mass="10928" checksum="B03A88431B1DBD70" modified="2005-11-22" version="1">MDERKEYVEKLSAQIVEWDAQIDRLKDKAESATPEERFDYHNTITALQLKRDEAAEKLQGISAATDDEWEDLKTGTEQIWGEVKSILCDAIKKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WI9</accession>
    <name>Q39WI9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513411.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1147"/>
    <dbReference type="EnsemblBacteria" id="ABB31385">
        <property type="protein sequence ID" value="ABB31385"/>
        <property type="gene ID" value="Gmet_1147"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1147"/>
    <dbReference type="HOGENOM" id="CLU_352941_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="796" mass="89897" checksum="D536D939C3BEFD80" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WK2</accession>
    <name>Q39WK2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513398.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1134"/>
    <dbReference type="EnsemblBacteria" id="ABB31372">
        <property type="protein sequence ID" value="ABB31372"/>
        <property type="gene ID" value="Gmet_1134"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1134"/>
    <dbReference type="HOGENOM" id="CLU_198213_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="77" mass="8551" checksum="074329A6A7EC1538" modified="2005-11-22" version="1">MLTIDRLRLQLPPAFRDRAGEIAQLVAEELATVPMASDFHLDRLAVPPVEVHPQATDRDVARAVAQSVHTGIRNETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WP6</accession>
    <name>Q39WP6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Lipoprotein cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1088</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513744.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1088"/>
    <dbReference type="EnsemblBacteria" id="ABB31328">
        <property type="protein sequence ID" value="ABB31328"/>
        <property type="gene ID" value="Gmet_1088"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1088"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134966_0_0_7"/>
    <dbReference type="OMA" id="FKYGRTP"/>
    <dbReference type="OrthoDB" id="1315115at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="65"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="143" mass="15020" checksum="126F1C2B485B2C16" modified="2005-11-22" version="1">MHDRSIVTKLKGSGHRSIIVVAILAGCLAAAGCKQQEKPVQAPAEKPATGAVPQTTMGGPMSDQQTQAMGKAIFKKQCAGCHGEEGKGMSAPSLQKADFKYGRTPEAIKETITKGRPGGMPAFGNLQEIEVETLVAYVLGLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WS0</accession>
    <name>Q39WS0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CRISPR-associated nuclease and helicase Cas3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cas3</name>
        <name evidence="11" type="ordered locus">Gmet_1064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the CRISPR-associated helicase Cas3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513240.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1064"/>
    <dbReference type="EnsemblBacteria" id="ABB31304">
        <property type="protein sequence ID" value="ABB31304"/>
        <property type="gene ID" value="Gmet_1064"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1064"/>
    <dbReference type="eggNOG" id="COG1203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010123_0_0_7"/>
    <dbReference type="OMA" id="HLSTNMC"/>
    <dbReference type="OrthoDB" id="1149839at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035011">
        <property type="entry name" value="Cas3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006483">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038257">
        <property type="entry name" value="CRISPR-assoc_Cas3_HD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006474">
        <property type="entry name" value="Helicase_Cas3_CRISPR-ass_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031:SF539">
        <property type="entry name" value="PTHR24031:SF539"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01587">
        <property type="entry name" value="cas3_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01596">
        <property type="entry name" value="cas3_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51643">
        <property type="entry name" value="HD_CAS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD Cas3-type" evidence="10">
        <location>
            <begin position="11"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="226"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="722" mass="81114" checksum="321E4FE56BAC8B07" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X55</accession>
    <name>Q39X55_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell shape-determining protein MreD, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">mreD</name>
        <name evidence="9" type="ordered locus">Gmet_0927</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MreD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513957.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0927"/>
    <dbReference type="EnsemblBacteria" id="ABB31169">
        <property type="protein sequence ID" value="ABB31169"/>
        <property type="gene ID" value="Gmet_0927"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0927"/>
    <dbReference type="eggNOG" id="COG2891">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132534_3_0_7"/>
    <dbReference type="OMA" id="YLLDPFQ"/>
    <dbReference type="OrthoDB" id="1731648at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007227">
        <property type="entry name" value="Cell_shape_determining_MreD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04093">
        <property type="entry name" value="MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03426">
        <property type="entry name" value="shape_MreD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0133">Cell shape</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="161" mass="17670" checksum="05F274D2193D0370" modified="2005-11-22" version="1">MIKFLWYAILVFAALVMQVTLFPAHIADPFKPNLLIIFVVYMGLREGVAWGALAYVLGLIHDSFSGLYLGLNGFSYLIIFLGLTMVADRLFTDRRSLMILGVFSSTIVNGLLNLLLLFLFSSAQGIYATLLESLVPQALVNALVASVIFTVPPLARIGEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X71</accession>
    <name>Q39X71_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513941.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0911"/>
    <dbReference type="EnsemblBacteria" id="ABB31153">
        <property type="protein sequence ID" value="ABB31153"/>
        <property type="gene ID" value="Gmet_0911"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0911"/>
    <dbReference type="eggNOG" id="ENOG50321RF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682884_0_0_7"/>
    <dbReference type="OMA" id="KNVGPVA"/>
    <dbReference type="OrthoDB" id="674207at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223242" evidence="1">
        <location>
            <begin position="24"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="403" mass="45402" checksum="A8530CE2F9D4CCC6" modified="2005-11-22" version="1">MGIKGFTRLLLLAGVLSASSGLAAEIHGRSSTQLSWFNNYYNDKKQVELGEYLRLSVTNLDKEGKASIYGYGRITQDLNNGEGFNSRLYYLYGEYRDLYDKVDIRLGRQFINQAAGSAIIDGGQIDLKNVGPVALSVYGGRNVIFGLDNESGHGGDLAFGAAAYLQGFKNTDLEVSWLRKWDQWDIARDTLGASFKQYLFNSVRLYGNTRFDLVSETFNEVLAGVKYYPLSNLVFTGEWYQSYPTFDTTSIYSVFAVDRYQEAVFRADYTFNDMVSVNGGYTSQWFGEGGRGHIYHLGTGVRPFEPLLINVEFDNNQGYNGKTNGVLVDAFYDVTKSLQVAGGLGYDVYKRDVMNNDEIARTYWLGGKYKLAKSMTASLRVENNVNARYENDTQGRFVFDYDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XB3</accession>
    <name>Q39XB3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0869</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513015.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0869"/>
    <dbReference type="EnsemblBacteria" id="ABB31111">
        <property type="protein sequence ID" value="ABB31111"/>
        <property type="gene ID" value="Gmet_0869"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0869"/>
    <dbReference type="eggNOG" id="ENOG5033G78">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2069756_0_0_7"/>
    <dbReference type="OMA" id="WEEGTWA"/>
    <dbReference type="OrthoDB" id="2074486at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="117" mass="13154" checksum="0001AD9C8E34A5C3" modified="2005-11-22" version="1">MTDERMTRFLHRFAAAAEAHAAAMEAMDENKVNRHAFVLQGLYREIVLTGEAGREGLLALVDSDRKAVAGMAAVYSLRYCPERAITVLRRLSAEEGLLGFRAGMALERWERGEWNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XD8</accession>
    <name>Q39XD8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Malonyl-[acyl-carrier protein] O-methyltransferase</fullName>
            <shortName evidence="5">Malonyl-ACP O-methyltransferase</shortName>
            <ecNumber evidence="3 5">2.1.1.197</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Biotin synthesis protein BioC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 7" type="primary">bioC</name>
        <name evidence="7" type="ordered locus">Gmet_0844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>malonyl-[ACP] + S-adenosyl-L-methionine = malonyl-[ACP] methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:17105"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9954"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78845"/>
            <dbReference type="EC" id="2.1.1.197"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.197" evidence="3 5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512988.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0844"/>
    <dbReference type="EnsemblBacteria" id="ABB31086">
        <property type="protein sequence ID" value="ABB31086"/>
        <property type="gene ID" value="Gmet_0844"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0844"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046586_2_2_7"/>
    <dbReference type="OMA" id="SWQAVDG"/>
    <dbReference type="OrthoDB" id="1664438at2"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010340">
        <property type="term" value="F:carboxyl-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102130">
        <property type="term" value="F:malonyl-CoA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00835">
        <property type="entry name" value="BioC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011814">
        <property type="entry name" value="BioC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="6">
        <location>
            <begin position="47"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="269" mass="29517" checksum="5DD2E10F27BC31A8" modified="2005-11-22" version="1">MIDRRRVRHSFHRQALEYDAHAAVQKRVVERFLQILDDEVGSPLRILDVGAGTGLLARQLADCHPAALLSCVDLAPGMAATARQRLGSRALVAVADAEHLPFAGASFDCVVSTSTFQWLTTLDAAFGEVWRVLAPGGLFAFALFGHGTFHELKDSYRSALTAVGREDEDRTQRFFTEAEAGAALERTGFGVRRLCVEDEVEWHPDVPAFLRSVKRVGAGNASPLRGRGLAERRVMVEMMRVYGERYGGERGIPATYTVIYGVGVKSGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XG1</accession>
    <name>Q39XG1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis sensory transducer, class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mcp40H-6</name>
        <name evidence="6" type="ordered locus">Gmet_0821</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514408.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0821"/>
    <dbReference type="EnsemblBacteria" id="ABB31063">
        <property type="protein sequence ID" value="ABB31063"/>
        <property type="gene ID" value="Gmet_0821"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0821"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_7"/>
    <dbReference type="OMA" id="DRVQKYA"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="214"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="273"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="545" mass="58158" checksum="29E26922AE3F315E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XH9</accession>
    <name>Q39XH9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365726.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0803"/>
    <dbReference type="EnsemblBacteria" id="ABB31045">
        <property type="protein sequence ID" value="ABB31045"/>
        <property type="gene ID" value="Gmet_0803"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0803"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_28_1_7"/>
    <dbReference type="OMA" id="HFSNKEV"/>
    <dbReference type="OrthoDB" id="2047542at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011075">
        <property type="entry name" value="TetR_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16925">
        <property type="entry name" value="TetR_C_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="196" mass="22145" checksum="C3E30FD49617D7AC" modified="2005-11-22" version="1">MDKNETRATIIRIGTDLIGRQGFNATGIDAVLREAGVPKGSFYYYFRSKEEFGLAVIDHFAERYDQRLDTFLNDDEVTPLNRLRNLLESGLARLEQNQCAKGCLIGNLGQELADQNERFRARLEEVFTSWKKRYAACLREAQRAGELAPELDPSVVAGFILSGWEGAVLRAKVMKSPQPLRDFIATLFATVLREQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XJ2</accession>
    <name>Q39XJ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dienelactone hydrolase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513535.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0790"/>
    <dbReference type="ESTHER" id="geomg-q39xj2">
        <property type="family name" value="Dienelactone_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31032">
        <property type="protein sequence ID" value="ABB31032"/>
        <property type="gene ID" value="Gmet_0790"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0790"/>
    <dbReference type="eggNOG" id="COG0412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054590_3_1_7"/>
    <dbReference type="OMA" id="HGGPDIG"/>
    <dbReference type="OrthoDB" id="1889569at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223489" evidence="1">
        <location>
            <begin position="27"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DLH" evidence="2">
        <location>
            <begin position="42"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="269" mass="28952" checksum="F408E6B59989E247" modified="2005-11-22" version="1">MGGIRKFVWVAVALAGGFLGVSTADAAVQGKVVEYRDGEVTMKGYLAWNDTVKGKRPGVLVVHEWWGLNDYARKRARMLAELGYTALAVDMYGGGKEATHPDDAGAFSSAVMKNMDLMAARFRAAMEFLKKQPTVDAVRIGAIGYCFGGAVVLNMARQGLDLKGVASFHGNLATAKPAGPGTVKAKVTVFNGGADTLVPPEQVGAFTAEMTRAGAAFRFFSYPGAKHAFTNPDADVYARKFGLPLAYDAAADRDSWEEMKRFFREVFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XP8</accession>
    <name>Q39XP8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus minor pilin PilV</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilV-1</name>
        <name evidence="2" type="ordered locus">Gmet_0734</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514451.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0734"/>
    <dbReference type="EnsemblBacteria" id="ABB30976">
        <property type="protein sequence ID" value="ABB30976"/>
        <property type="gene ID" value="Gmet_0734"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0734"/>
    <dbReference type="eggNOG" id="COG4967">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2000633_0_0_7"/>
    <dbReference type="OMA" id="MSINSGR"/>
    <dbReference type="OrthoDB" id="2065852at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="132" mass="14964" checksum="39A927C9AE664937" modified="2005-11-22" version="1">MTSRLNQKGYTLVEMLIAMFLLVVGFLSVFLVLWASTTSGRFSRDMTTAANLGQDMLERIGTMKYDDLPETSGFQNYPEPFGDKSLAAAAFEARQWRISSAGSMKIVTARISWIKNGARKTRDFTMVRRKEY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XS5</accession>
    <name>GLGA1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycogen synthase 1</fullName>
            <ecNumber evidence="1">2.4.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Starch [bacterial glycogen] synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgA1</name>
        <name type="ordered locus">Gmet_0707</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Synthesizes alpha-1,4-glucan chains using ADP-glucose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + ADP-alpha-D-glucose = [(1-&gt;4)-alpha-D-glucosyl](n+1) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18189"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9587"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.4.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514099.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XS5"/>
    <dbReference type="SMR" id="Q39XS5"/>
    <dbReference type="STRING" id="269799.Gmet_0707"/>
    <dbReference type="CAZy" id="GT5">
        <property type="family name" value="Glycosyltransferase Family 5"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30949">
        <property type="protein sequence ID" value="ABB30949"/>
        <property type="gene ID" value="Gmet_0707"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0707"/>
    <dbReference type="eggNOG" id="COG0297">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_18_2_7"/>
    <dbReference type="OMA" id="CGWVHGR"/>
    <dbReference type="OrthoDB" id="83240at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033201">
        <property type="term" value="F:alpha-1,4-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004373">
        <property type="term" value="F:glycogen (starch) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009011">
        <property type="term" value="F:starch synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00484">
        <property type="entry name" value="Glycogen_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011835">
        <property type="entry name" value="GS/SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02095">
        <property type="entry name" value="glgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000230241" description="Glycogen synthase 1">
        <location>
            <begin position="1"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ADP-alpha-D-glucose</name>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00484"/>
        </source>
    </evidence>
    <sequence length="502" mass="56508" checksum="C21743C749EDFE6D" modified="2005-11-22" version="1">MKKLKILMAASECVPFAKEGGLADVVGVLPKHLARMGHDVRVVMPRYKRVDRERYGLKQLPGVLVVPMGVIGNQYCGVWEGRIPGSDVPVYFLEHEGYYDRDGLYEVNNEGFLDNDNRFVFLSKAALELPKMIGFEPDLLHAHDWHTAAIPVLVNTTYAADPYVGGKATVLSVHNMQHQGNFYEGLMDVLGIGWEHFTFLGLENNGEANLLKGGLYHATVLNTVSEGYAREMQTPEYGWGLDGVVRERAADLYGILNGVDYEDWNPEVDPYIAARYSAADLSGKKLCKRDLQRTFGLPERDDVPLFGMVSRLVKQKGVDILAEAIHRILALDVQFVMLGAGEPWTHFYFGDIKNAYPDKFNIFVGYNNPLSHQIEAGADFFLMPSAFEPCGLNQMYSLRYGTLPIVRATGGLDDSVENFDEKTLVGTGFKFWSRDAGALFDTVGWAVHTWYHRKDAMERLIANAMAKRFTWEDAAARYEDLYGRALRKRLGEKEFARRYGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XU9</accession>
    <name>Q39XU9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">etfB-1</name>
        <name evidence="4" type="ordered locus">Gmet_0683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514074.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0683"/>
    <dbReference type="EnsemblBacteria" id="ABB30925">
        <property type="protein sequence ID" value="ABB30925"/>
        <property type="gene ID" value="Gmet_0683"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0683"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_2_1_7"/>
    <dbReference type="OMA" id="TNVYKSF"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="22"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="272" mass="29448" checksum="91909238CA5EC63F" modified="2005-11-22" version="1">MLAIACIKQVPDTTQVKIDPVTNTLVREGIPFIVNPYDTHALEESLRIKDRFGFRAVALSMGPPNAEAALRKALSMGADDAILCSDRCFGGADTLSTSNVLAAAIKRIAQETGEEVGIVFCGKQTIDGDTAQVGPGIAVRLGFTPLTLVDRIEALDPVNRRIKVRRKLEGRYEVVEASLPVMITAVRELNRPRYPSVPMRLAAADAQVTVWTNEVLRMDVNSVGLKGSPTWVSRIFSPERDKGEIIGDGMADPTGTARLLIDQLLAKDLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XV8</accession>
    <name>Q39XV8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">NAD(+)--nitrogenase ADP-D-ribosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">draT</name>
        <name evidence="1" type="ordered locus">Gmet_0674</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514065.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0674"/>
    <dbReference type="EnsemblBacteria" id="ABB30916">
        <property type="protein sequence ID" value="ABB30916"/>
        <property type="gene ID" value="Gmet_0674"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0674"/>
    <dbReference type="eggNOG" id="ENOG502Z8KN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965134_0_0_7"/>
    <dbReference type="OMA" id="FEFCQWA"/>
    <dbReference type="OrthoDB" id="917388at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030701">
        <property type="term" value="F:NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009953">
        <property type="entry name" value="DRA_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07357">
        <property type="entry name" value="DRAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="265" mass="30669" checksum="38FFD82D04E1F34E" modified="2005-11-22" version="1">MHNSGFNLCNLPPWVIASRHFNDNPHPLEVQGVRLANRFLFERLDAIASPDERGTVFNDYMSVKFQLHLWQEQATPSARKSLKNSYLRYLRGWMMDSNSVEGAVLKGWVESRMGIVPSFHKARITGIHTESYYGYVVDRTAGSKRTSAINSQLDILYEFCQYELARRFPGELWVTLYRGTFAADDYDVVEELGRREKIIRFNNLVSFTSHEERAWEFGSTVWEIRAPLSKVFFFDDLLPGSILKGEGEYLVIGGEYRVRRVMCTV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XZ1</accession>
    <name>RL6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplF</name>
        <name type="ordered locus">Gmet_0641</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514251.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XZ1"/>
    <dbReference type="SMR" id="Q39XZ1"/>
    <dbReference type="STRING" id="269799.Gmet_0641"/>
    <dbReference type="EnsemblBacteria" id="ABB30883">
        <property type="protein sequence ID" value="ABB30883"/>
        <property type="gene ID" value="Gmet_0641"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0641"/>
    <dbReference type="eggNOG" id="COG0097">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065464_1_2_7"/>
    <dbReference type="OMA" id="KPDPYKG"/>
    <dbReference type="OrthoDB" id="1398618at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01365_B">
        <property type="entry name" value="Ribosomal_L6_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_L6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_L6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_L6_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019906">
        <property type="entry name" value="Ribosomal_L6_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_L6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="PTHR11655"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF14">
        <property type="entry name" value="PTHR11655:SF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00059">
        <property type="entry name" value="RIBOSOMALL6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="SSF56053"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03654">
        <property type="entry name" value="L6_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000260873" description="50S ribosomal protein L6">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01365"/>
        </source>
    </evidence>
    <sequence length="179" mass="19561" checksum="889EEE6C7543FC08" modified="2005-11-22" version="1">MSRIGKRPIEIPSGVKVSYVTPILKVEGPKGSLLREIMSDIALEIEEKSVSVNRADDAIKSRSAHGLTRTLINNMVVGVTKGFEKILEINGVGYRAEAKGDVLSLSLGYSHPINFPLPKGITVEVDKMTKVFVRGIDKELVGQTAAKIRSFRGPEPYKGKGIKYADERILRKAGKTGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y67</accession>
    <name>Q39Y67_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin superfamily barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512261.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0564"/>
    <dbReference type="DNASU" id="3738221"/>
    <dbReference type="EnsemblBacteria" id="ABB30807">
        <property type="protein sequence ID" value="ABB30807"/>
        <property type="gene ID" value="Gmet_0564"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0564"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137371_2_0_7"/>
    <dbReference type="OMA" id="EIITHTH"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="34"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="106" mass="11896" checksum="03A6A98DC490326F" modified="2005-11-22" version="1">MKSQVFDVQKLKKFTDEKRHQETIWSDDHARVSLICMKPGQEIITHTHHGSHIWMVMEGTGEFLSGKQVQTITTGQIVIVPAFEDHGIRNGSQENLVIASITGQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y93</accession>
    <name>Q39Y93_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Menaquinol oxidoreductase complex Cbc6, iron-sulfur cluster-binding subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cbcO</name>
        <name evidence="9" type="ordered locus">Gmet_0538</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512234.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0538"/>
    <dbReference type="EnsemblBacteria" id="ABB30781">
        <property type="protein sequence ID" value="ABB30781"/>
        <property type="gene ID" value="Gmet_0538"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0538"/>
    <dbReference type="eggNOG" id="COG0723">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_1_1_7"/>
    <dbReference type="OMA" id="SEIVCPC"/>
    <dbReference type="OrthoDB" id="1632945at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="PTHR10134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="8">
        <location>
            <begin position="39"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="131" mass="14464" checksum="4C3887AF0FDA1487" modified="2005-11-22" version="1">MAAVDRGRRHFIAALIAFIASLAAAWRFLVPKRRESGERFVIDMAAVPPRGALVYRERRLAVMRDGGEIYALNLTCTHLGCTVTVTPGEIVCPCHGSRFDLKGNVLKGPADRPLARHRLEIRGGRVEIYPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YE1</accession>
    <name>Q39YE1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PPC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512186.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0490"/>
    <dbReference type="DNASU" id="3738323"/>
    <dbReference type="EnsemblBacteria" id="ABB30733">
        <property type="protein sequence ID" value="ABB30733"/>
        <property type="gene ID" value="Gmet_0490"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0490"/>
    <dbReference type="eggNOG" id="COG1661">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114051_2_3_7"/>
    <dbReference type="OMA" id="DERFAHT"/>
    <dbReference type="OrthoDB" id="1752865at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11378">
        <property type="entry name" value="DUF296"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025707">
        <property type="entry name" value="DNA_bp_PD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005175">
        <property type="entry name" value="PPC_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03479">
        <property type="entry name" value="PCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016702">
        <property type="entry name" value="DNA_bp_PD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51742">
        <property type="entry name" value="PPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="154" mass="16591" checksum="D121FE6C22416E18" modified="2005-11-22" version="1">MFMGKLPHQADLIGALIEAAGANGIRAGAIQVIGALQGAKLGFYDQWSKSYRELPFAKPLEIVSGLGNISLRDGRPFVHLHLSISDEEGKVFGGHALEGCTIFAAEYAIMPLPGSAPVRVFDETTGLFLWEREQYPASGQKGLSPELERALLNP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YJ7</accession>
    <name>FLGI_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellar P-ring protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Basal body P-ring protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">flgI</name>
        <name type="ordered locus">Gmet_0434</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Assembles around the rod to form the L-ring and probably protects the motor/basal body from shearing forces during rotation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgI family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512406.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YJ7"/>
    <dbReference type="SMR" id="Q39YJ7"/>
    <dbReference type="STRING" id="269799.Gmet_0434"/>
    <dbReference type="EnsemblBacteria" id="ABB30677">
        <property type="protein sequence ID" value="ABB30677"/>
        <property type="gene ID" value="Gmet_0434"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0434"/>
    <dbReference type="eggNOG" id="COG1706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045235_1_0_7"/>
    <dbReference type="OMA" id="KTIQITR"/>
    <dbReference type="OrthoDB" id="693640at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009428">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod, P ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030288">
        <property type="term" value="C:outer membrane-bounded periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00416">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001782">
        <property type="entry name" value="Flag_FlgI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30381">
        <property type="entry name" value="PTHR30381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02119">
        <property type="entry name" value="FlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01010">
        <property type="entry name" value="FLGPRINGFLGI"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0975">Bacterial flagellum</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000236301" description="Flagellar P-ring protein">
        <location>
            <begin position="22"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00416"/>
        </source>
    </evidence>
    <sequence length="365" mass="38379" checksum="7D6B8B169D4D9310" modified="2005-11-22" version="1" precursor="true">MIKRIISIVFLLLTLPQLALAVRIKDIASFDGVRENQLIGYGLVVGLNGTGDSDQTNFPVQSLANVLERMGVTVNRNDITVKNVAAVMVTANLPPFAKQGTRIDTLVSSMGDAKSIAGGTLLMTPLKGADGRVYAVAQGGVLTNSFSYGGQAASAQKNHPTAGRVPNGGLVELELPNVLSDRGQLRLNLHQPDFTTATRIAQAVNERFKGGVAAATDPGAVMMNLPEAYKGRVVEFVADMERLEVRPDAMAKVVLNERTGTIVIGDNVRISTVAVSHGNLTLYIKETPKVSQPAPFSKTGETVVVPRTEIKVNEGGGGLAVVKEGASIGEVVRALNALGVTPRDLIGILQAIKAAGAMQAEVEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YK0</accession>
    <name>Q39YK0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Flagellar basal-body rod protein FlgG</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6 7">Distal rod protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">flgG</name>
        <name evidence="10" type="ordered locus">Gmet_0431</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5 7">The basal body constitutes a major portion of the flagellar organelle and consists of four rings (L,P,S, and M) mounted on a central rod. The rod consists of about 26 subunits of FlgG in the distal portion, and FlgB, FlgC and FlgF are thought to build up the proximal portion of the rod with about 6 subunits each.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512403.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0431"/>
    <dbReference type="DNASU" id="3738362"/>
    <dbReference type="EnsemblBacteria" id="ABB30674">
        <property type="protein sequence ID" value="ABB30674"/>
        <property type="gene ID" value="Gmet_0431"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0431"/>
    <dbReference type="eggNOG" id="COG4786">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013687_0_1_7"/>
    <dbReference type="OMA" id="TRDGTFH"/>
    <dbReference type="OrthoDB" id="1488472at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009426">
        <property type="term" value="C:bacterial-type flagellum basal body, distal rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001444">
        <property type="entry name" value="Flag_bb_rod_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019776">
        <property type="entry name" value="Flagellar_basal_body_rod_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020013">
        <property type="entry name" value="Flagellar_FlgE/F/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010930">
        <property type="entry name" value="Flg_bb/hook_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037925">
        <property type="entry name" value="FlgE/F/G-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012834">
        <property type="entry name" value="FlgG_G_neg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00460">
        <property type="entry name" value="Flg_bb_rod"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06429">
        <property type="entry name" value="Flg_bbr_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117143">
        <property type="entry name" value="SSF117143"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03506">
        <property type="entry name" value="FlgEFG_subfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02488">
        <property type="entry name" value="flgG_G_neg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00588">
        <property type="entry name" value="FLAGELLA_BB_ROD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="10" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="10" id="KW-0282">Flagellum</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_bb_rod" evidence="8">
        <location>
            <begin position="7"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Flg_bbr_C" evidence="9">
        <location>
            <begin position="183"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF06429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="262" mass="27675" checksum="7CAD24D50E21FCD3" modified="2005-11-22" version="1">MIRALWTAASGMQAQQTNIDVVANNLANVNTAGFKKSRADFQDLMYQNMKTTGSPSTNTTQVPSGIQIGLGAKLAAVTKIFTIGNINQTGNELDMAIEGDGFYQIQMPDGTTTYTRSGAFKRDSQGRVVTSDGYPLIPEIVIPNNATAINIGNDGTVSVSQAGQKSPTNVGNIQLAMFSNPSGLLAIGKNLFQESDSSGNATTGTPGQNGLGTTAQGFLEMSNVSVMEEMVNMITGQRAYEVNSKAVQTADEMLQTANSLKR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-01-25" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YM0</accession>
    <name>FTSW_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable peptidoglycan glycosyltransferase FtsW</fullName>
            <shortName evidence="2">PGT</shortName>
            <ecNumber evidence="2">2.4.1.129</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Cell division protein FtsW</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Cell wall polymerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">Peptidoglycan polymerase</fullName>
            <shortName evidence="2">PG polymerase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ftsW</name>
        <name type="ordered locus">Gmet_0411</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Peptidoglycan polymerase that is essential for cell division.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="2">Localizes to the division septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEDS family. FtsW subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YM0"/>
    <dbReference type="SMR" id="Q39YM0"/>
    <dbReference type="STRING" id="269799.Gmet_0411"/>
    <dbReference type="EnsemblBacteria" id="ABB30654">
        <property type="protein sequence ID" value="ABB30654"/>
        <property type="gene ID" value="Gmet_0411"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0411"/>
    <dbReference type="eggNOG" id="COG0772">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029243_0_1_7"/>
    <dbReference type="OMA" id="KLWWSNL"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00913">
        <property type="entry name" value="PGT_FtsW_proteobact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018365">
        <property type="entry name" value="Cell_cycle_FtsW-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013437">
        <property type="entry name" value="FtsW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001182">
        <property type="entry name" value="FtsW/RodA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30474">
        <property type="entry name" value="PTHR30474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01098">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02614">
        <property type="entry name" value="ftsW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00428">
        <property type="entry name" value="FTSW_RODA_SPOVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000415183" description="Probable peptidoglycan glycosyltransferase FtsW">
        <location>
            <begin position="1"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="103"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="167"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="191"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="topological domain" description="Periplasmic" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="1">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00913"/>
        </source>
    </evidence>
    <sequence length="375" mass="41325" checksum="D57EE7BE0386B98B" modified="2005-11-22" version="1">MNLNFKLNLKEIERYDLVILLMAVALTCFGVVMVYSASSVMATKKFHDGFYFLKRQGIYAILGCAAMIVAMRIDYRQWREYAVPILLGCLLLLLLVFIPGIGGAAKGASRWIRFPGFNLQPSELAKIALIMYMAYSLDKKQEKVKFFSTGFAPYMVLLAILLAILLKQHDLGSALTMGGVAILMLFAAGTRPRYILGMVVLTLPFLYFLVMNVDYRRRRILAYLNPWEDPTNTGFQIIQSWLAFGNGGIIGQGLGEGKQKMFFLPEAHTDFILSVVGEELGLIGVIVIAAMFLMLVLRGVRVALMAQDPFGRFLAFGIVTLLGIQAFVNMGVVTGLLPTKGLALPFISYGGSSLIVTLFAVGILLNVSTRMKGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YN5</accession>
    <name>Q39YN5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase</fullName>
            <ecNumber evidence="3">4.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0396</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512368.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0396"/>
    <dbReference type="EnsemblBacteria" id="ABB30639">
        <property type="protein sequence ID" value="ABB30639"/>
        <property type="gene ID" value="Gmet_0396"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0396"/>
    <dbReference type="eggNOG" id="COG2606">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094875_1_0_7"/>
    <dbReference type="OMA" id="PYDYVEH"/>
    <dbReference type="OrthoDB" id="1503081at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00002">
        <property type="entry name" value="YbaK_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004369">
        <property type="entry name" value="Prolyl-tRNA_editing_YbaK/EbsC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006181">
        <property type="entry name" value="EbsC_YbaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="SSF55826"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00011">
        <property type="entry name" value="YbaK_EbsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA_edit" evidence="4">
        <location>
            <begin position="40"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="161" mass="17484" checksum="85D7F26DC7B0055B" modified="2005-11-22" version="1">MAKESKAPVTAAVRALRAAKVPFTDHLYAYEEKGGTAVSSRELEVDEHAVVKTLIMEDEAKNPLIVLMHGDRQVSTKELARVLGVKGVSPCSPDTAQKHTGYLVGGTSPFGTRRQMPVCMEETILDLPCIYINGGKRGYLVGIDPRDVVKLLNPTLVRVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YR5</accession>
    <name>Q39YR5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribonuclease J</fullName>
            <shortName evidence="9">RNase J</shortName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">rnj</name>
        <name evidence="12" type="ordered locus">Gmet_0366</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, may be a subunit of the RNA degradosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512338.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0366"/>
    <dbReference type="EnsemblBacteria" id="ABB30609">
        <property type="protein sequence ID" value="ABB30609"/>
        <property type="gene ID" value="Gmet_0366"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0366"/>
    <dbReference type="eggNOG" id="COG0595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008727_3_1_7"/>
    <dbReference type="OMA" id="KNTCVFE"/>
    <dbReference type="OrthoDB" id="580619at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01491">
        <property type="entry name" value="RNase_J_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004613">
        <property type="entry name" value="RNase_J"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042173">
        <property type="entry name" value="RNase_J_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030854">
        <property type="entry name" value="RNase_J_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041636">
        <property type="entry name" value="RNase_J_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001587">
        <property type="entry name" value="RNase_J_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17770">
        <property type="entry name" value="RNase_J_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004803">
        <property type="entry name" value="RnjA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00649">
        <property type="entry name" value="MG423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01292">
        <property type="entry name" value="UPF0036"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5 9 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lactamase_B" evidence="11">
        <location>
            <begin position="23"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9 10">
        <location>
            <begin position="367"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR004803-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB30609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="558" mass="61976" checksum="467FDB57C5A8E467" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YX1</accession>
    <name>Q39YX1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Succinate dehydrogenase/fumarate reductase, type E, flavoprotein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">sdhA</name>
        <name evidence="13" type="ordered locus">Gmet_0308</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514020.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0308"/>
    <dbReference type="EnsemblBacteria" id="ABB30553">
        <property type="protein sequence ID" value="ABB30553"/>
        <property type="gene ID" value="Gmet_0308"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0308"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_6_2_7"/>
    <dbReference type="OMA" id="DPIPIQP"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="PTHR11632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="SSF46977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="11">
        <location>
            <begin position="6"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Succ_DH_flav_C" evidence="12">
        <location>
            <begin position="441"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB30553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="567" mass="62164" checksum="604D9FE383141394" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YY0</accession>
    <name>Q39YY0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HPP family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514010.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0299"/>
    <dbReference type="EnsemblBacteria" id="ABB30544">
        <property type="protein sequence ID" value="ABB30544"/>
        <property type="gene ID" value="Gmet_0299"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0299"/>
    <dbReference type="eggNOG" id="COG3448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040397_3_0_7"/>
    <dbReference type="OMA" id="GAYSWSY"/>
    <dbReference type="OrthoDB" id="2008563at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007065">
        <property type="entry name" value="HPP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04982">
        <property type="entry name" value="HPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="175" mass="18357" checksum="F3DD0E94D325E11E" modified="2005-11-22" version="1">MKRRIVQLPRKMRGRGGRPSSPPLSLKYAIWGVLSSTVGILAIFAATRMAGHPYLIGSFGASAVLLFGAPDATFAQPRNLIGGQLLSAAVAVVVVACGGSGPVAIALAVGLANLLMYVTRTVHPPGGAIALLGVQGHVGASYLIDPILVGVLILLTVALFTNNIVHHRQYPKYWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z25</accession>
    <name>Q39Z25_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein, UPF0126 and UPF0126 domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0254</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0126 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513570.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0254"/>
    <dbReference type="EnsemblBacteria" id="ABB30499">
        <property type="protein sequence ID" value="ABB30499"/>
        <property type="gene ID" value="Gmet_0254"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0254"/>
    <dbReference type="eggNOG" id="COG2860">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064906_2_1_7"/>
    <dbReference type="OMA" id="RAPRAWN"/>
    <dbReference type="OrthoDB" id="1665397at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005115">
        <property type="entry name" value="Gly_transporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03458">
        <property type="entry name" value="Gly_transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="6"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Gly_transporter" evidence="8">
        <location>
            <begin position="92"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="205" mass="22063" checksum="5B903E9ADB48FC67" modified="2005-11-22" version="1">MNLLYALDLLGTAAFAASGAWAGIRRDMDLFGVLMLGLVTATGGGTLRDLFLGDTPPFIFKDETYLYLSIAVSLAIFLFHKRLEFLHHPLLYFDAVGLGTFVVIGTGKALAFKMGFVGSVMMGVMTATAGGMIRDVLSTHIPLVLQKEVYASACIAGAALLFLLDRISFPRTLSLLAAAMTVIVVRLLAIRYNWSLPRAGGERNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z59</accession>
    <name>Q39Z59_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Diaminopimelate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">lysA</name>
        <name evidence="5" type="ordered locus">Gmet_0219</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512808.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0219"/>
    <dbReference type="EnsemblBacteria" id="ABB30465">
        <property type="protein sequence ID" value="ABB30465"/>
        <property type="gene ID" value="Gmet_0219"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0219"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026444_0_2_7"/>
    <dbReference type="OMA" id="HGNAKSP"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008836">
        <property type="term" value="F:diaminopimelate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06828">
        <property type="entry name" value="PLPDE_III_DapDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002986">
        <property type="entry name" value="DAP_deCOOHase_LysA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01181">
        <property type="entry name" value="DAPDCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orn_Arg_deC_N" evidence="4">
        <location>
            <begin position="45"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="3">
        <location>
            <begin position="283"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="439" mass="47952" checksum="CABAC4D32B5AD61A" modified="2005-11-22" version="1">MTMTSFGPTGLDATLIPKIAGEWGTPIYLHDQQYIENSCDQLLAMPNAYGLHVRYAIKANSDRTVLRIVTGKGLDLDCSSLDEAARAHAAGIPYSRMMLTTQEVPTGEERTELEAMIKVGLKYNVCSTLQYQLIADFAAQNKIDLSMRVHPGAAGGGESATRDTGSEYSCFGVHLRDVPTVKALADEKGLRFTQVHVHIGSGGAPEKWQENIDRELGFIKTYFPDAVTVSFGGGLKVARMPGEKQADIATLGAYAKQRIEEFKAATGRELMMEIEPGTFVVANSGHIVTRIIDKKFTNEMNFLIVDGGMELLTRPLLYGSEHPIAIVRQDGTLLSSEYDQTPTAGLKPFGIVGRCCESGDSVRLDKEGNIVPVMIVEPEIGDYVVIGGTGAYSESMSPENYNSHRKPGAVMRTKTGELVLIRKKQVREQLTQNELDVTL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-12-15" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZB0</accession>
    <name>NUOK1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit K 1</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit K 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit K 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoK1</name>
        <name type="ordered locus">Gmet_0167</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 4L family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512754.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZB0"/>
    <dbReference type="SMR" id="Q39ZB0"/>
    <dbReference type="STRING" id="269799.Gmet_0167"/>
    <dbReference type="EnsemblBacteria" id="ABB30414">
        <property type="protein sequence ID" value="ABB30414"/>
        <property type="gene ID" value="Gmet_0167"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0167"/>
    <dbReference type="eggNOG" id="COG0713">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144724_0_1_7"/>
    <dbReference type="OMA" id="MMLIGIE"/>
    <dbReference type="OrthoDB" id="2081663at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01456">
        <property type="entry name" value="NDH1_NuoK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001133">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chain4L/K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039428">
        <property type="entry name" value="NUOK/Mnh_C1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11434">
        <property type="entry name" value="PTHR11434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00420">
        <property type="entry name" value="Oxidored_q2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000390078" description="NADH-quinone oxidoreductase subunit K 1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01456"/>
        </source>
    </evidence>
    <sequence length="102" mass="11134" checksum="F7FFB67A16445257" modified="2005-11-22" version="1">MIVPFEHVLILAGILFALGLVCVLVWRMNLIMLLIGIEVMLNAAMLAFVGGAARWGMADGQVFSLVIMALTSAEVSLALAMVVYLHRRKRTVDADEFSELKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZD1</accession>
    <name>Q39ZD1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512729.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0144"/>
    <dbReference type="EnsemblBacteria" id="ABB30393">
        <property type="protein sequence ID" value="ABB30393"/>
        <property type="gene ID" value="Gmet_0144"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0144"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_503227_0_0_7"/>
    <dbReference type="OMA" id="YKPWGLP"/>
    <dbReference type="OrthoDB" id="311458at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiolase_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="535" mass="58305" checksum="946FE584A6D70741" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZK0</accession>
    <name>GATA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
            <shortName evidence="1">Glu-ADT subunit A</shortName>
            <ecNumber evidence="1">6.3.5.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatA</name>
        <name type="ordered locus">Gmet_0075</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.7"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family. GatA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514199.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZK0"/>
    <dbReference type="SMR" id="Q39ZK0"/>
    <dbReference type="STRING" id="269799.Gmet_0075"/>
    <dbReference type="EnsemblBacteria" id="ABB30324">
        <property type="protein sequence ID" value="ABB30324"/>
        <property type="gene ID" value="Gmet_0075"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0075"/>
    <dbReference type="eggNOG" id="COG0154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009600_0_3_7"/>
    <dbReference type="OMA" id="EVSCPHF"/>
    <dbReference type="OrthoDB" id="1239251at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030956">
        <property type="term" value="C:glutamyl-tRNA(Gln) amidotransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00120">
        <property type="entry name" value="GatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004412">
        <property type="entry name" value="GatA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="PTHR11895"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="SSF75304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00132">
        <property type="entry name" value="gatA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000241105" description="Glutamyl-tRNA(Gln) amidotransferase subunit A">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="1">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00120"/>
        </source>
    </evidence>
    <sequence length="485" mass="51712" checksum="2A0F508871A273F1" modified="2005-11-22" version="1">MELFDLTIHELHDRLKRKELSSVEATRAMLARIEAVDPKVNAYITVTPEEALAAAEAADRRIAAGDMAPLTGIPVALKDIFVTKGIRTTCASKILDNFVPPYDGTAVAKLKEAGAVIVGKLNQDEFAMGSSGESSAFGPTRNPWNLECIPGGSSSGSAAAIAARTATATLGTDTGGSIRQPASHCGCVGLRPTYGRVSRYGVIAYASSLDQVGPVTRDVTDCALMLQAVAGHDPMDSTSVEVPVPDYAKGLTGDVKGLKLGLPKEYYIEGLDPDVKKALDEAIETYRGLGAEFVDISLPHTDYAVATYYLIATAEASSNLARYEGVRFGHRTEGAANLIDMFRKTRSEGFGDEVKRRIMIGTYALSSGYYDAYYLKAQKVRTLIMQDFLKAFEAVDAILTPVAPTPAFKIGEKTSDPLRMYLSDIFTIPVNLAGTCAVSVPAGMSGAGLPIGLQLIGRPFGEETILRAAHAFEQATAWHTQKAGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZL8</accession>
    <name>SYC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cysteine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cysteinyl-tRNA synthetase</fullName>
            <shortName evidence="1">CysRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cysS</name>
        <name type="ordered locus">Gmet_0057</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)</text>
            <dbReference type="Rhea" id="RHEA:17773"/>
            <dbReference type="Rhea" id="RHEA-COMP:9661"/>
            <dbReference type="Rhea" id="RHEA-COMP:9679"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78517"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514181.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZL8"/>
    <dbReference type="SMR" id="Q39ZL8"/>
    <dbReference type="STRING" id="269799.Gmet_0057"/>
    <dbReference type="PRIDE" id="Q39ZL8"/>
    <dbReference type="EnsemblBacteria" id="ABB30306">
        <property type="protein sequence ID" value="ABB30306"/>
        <property type="gene ID" value="Gmet_0057"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0057"/>
    <dbReference type="eggNOG" id="COG0215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013528_0_1_7"/>
    <dbReference type="OMA" id="AKYWMHN"/>
    <dbReference type="OrthoDB" id="952207at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015273">
        <property type="entry name" value="Cys-tRNA-synt_Ia_DALR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="PTHR10890"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09190">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00840">
        <property type="entry name" value="DALR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000240916" description="Cysteine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="266"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00041"/>
        </source>
    </evidence>
    <sequence length="485" mass="54737" checksum="50125AD6C2FDDC03" modified="2005-11-22" version="1">MSLRVYNTLSGTKEEFTPLVPGRVSMYVCGVTVYDHCHIGHARANVVFDMIYRYLRHAGYDVTYVRNYTDVDDKIINRANQEGVPYNAISERFIAEFDRDMAALGLDLPTHQPKATEHIAEMIDVISRLIEKGFAYAADGDVYFCVEKFDPYLKLSKRNLDEMQAGARIEVGEKKRHPMDFALWKGSKPGEPFWESPWGQGRPGWHIECSAMSMKYLGETFDIHGGGKDLVFPHHENEIAQSEAANGKPFAHYWIHNGFVNINSEKMSKSLGNFFTIKEVLEKYDAEVLRFFLLSAHYRSPIDFSDQNLREAEAGLERIYGTLAGIDENLTKGAEGTAEETDRELAEKAVTFPERFREAMDDDFNTAQALGFVFDLVRSANRVLGEGKGGGSNRALLAEARDRIRKVGAVLGIFTSEPRAFAERLKNRKAAELPITAEEIERLIAERIAARANRDFKRADEIRDSLAAKGIMLLDSPQGTTWKVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZN2</accession>
    <name>Q39ZN2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclase/hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513809.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0042"/>
    <dbReference type="EnsemblBacteria" id="ABB30292">
        <property type="protein sequence ID" value="ABB30292"/>
        <property type="gene ID" value="Gmet_0042"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0042"/>
    <dbReference type="eggNOG" id="COG1878">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030671_3_1_7"/>
    <dbReference type="OMA" id="GHPTHKT"/>
    <dbReference type="OrthoDB" id="831439at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31118">
        <property type="entry name" value="PTHR31118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="SSF102198"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="226" mass="24367" checksum="D6D313761B362863" modified="2005-11-22" version="1">MTIHDITVPLSPDLPVYPGDPPVTCEPVTRIARGDTANVTRITMTTHSGTHLDVPGHCRDGGATVDHLPLSLLMGKARVLDIRGERAIGRRELSRLPVRGEERLLLRTDNSLLWESPGFQDDFAHLTEEGAAFLIEAGVRLVGIDYLSIEGIASGITVHRMLLDAGVVILEGITLAEVEPGEYELVCLPLKIAGGDGAPARAILRGREPKGGETPFDPHTTRWPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="28" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYI8</accession>
    <name>J7LYI8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3638</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3638"/>
    <dbReference type="EnsemblBacteria" id="AFR42853">
        <property type="protein sequence ID" value="AFR42853"/>
        <property type="gene ID" value="Gmet_3638"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3638"/>
    <dbReference type="HOGENOM" id="CLU_2232697_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="105" mass="11960" checksum="3ADB0B3DFAE90B8C" modified="2012-10-31" version="1">MLFRRSPPFPREMSRRNWLKYPLQKQKPFSPFSGKGEKGSFSQCAKPAGDPAGCEHASKIVIRTCRHRHLCVHIRDEILLNNQVLSIANCMGHCVISVKTWIMPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEL7</accession>
    <name>J9JEL7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3645"/>
    <dbReference type="EnsemblBacteria" id="AFR42784">
        <property type="protein sequence ID" value="AFR42784"/>
        <property type="gene ID" value="Gmet_3645"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3645"/>
    <dbReference type="HOGENOM" id="CLU_3118264_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="50" mass="5455" checksum="E6A1BB071E9E4968" modified="2012-10-31" version="1">MEGSKRFGETYRTWATGEKTEGICEVCGAELEIDPESGEQSCPSCDNPEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PV5</accession>
    <name>Q39PV5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513670.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33719">
        <property type="protein sequence ID" value="ABB33719"/>
        <property type="gene ID" value="Gmet_3514"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3514"/>
    <dbReference type="eggNOG" id="ENOG5033GFE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_525574_0_0_7"/>
    <dbReference type="OMA" id="ETANAYW"/>
    <dbReference type="OrthoDB" id="2120882at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="SSF50969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223245" evidence="1">
        <location>
            <begin position="22"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="518" mass="54748" checksum="D68EA8304FD1E109" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PX4</accession>
    <name>Q39PX4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine phosphatase, SpoIIE domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513652.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3495"/>
    <dbReference type="EnsemblBacteria" id="ABB33700">
        <property type="protein sequence ID" value="ABB33700"/>
        <property type="gene ID" value="Gmet_3495"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3495"/>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078188_0_0_7"/>
    <dbReference type="OMA" id="LFATCTF"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="40"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="262" mass="28701" checksum="71A6E6994DCD22CD" modified="2005-11-22" version="1">MTEKKRGKGGLRVDPFELKLAREVERLLFPKSSPVCTWNCIGVKNRTAGVLGGDYFDSITLPDGRLALIVGDVTGHGLHASVVMSMLYGFIHHAAFDQIEPKGLAAQVNAFLSHFAERSRTFDLYFSTTLFMGIIDPTTLKLEYINAGHVPPLIRRADGIIELPPTTNPLGYFKALDIPSASVRLEQGDRLLLYTDGIIEAVNPAGDRFGLERLKETLAGNSPDHMEFLDRVFAGLRSFGAADPPEDDCTLLVVDIHGQVPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PZ1</accession>
    <name>Q39PZ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MglA-related GTPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513925.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3475"/>
    <dbReference type="EnsemblBacteria" id="ABB33683">
        <property type="protein sequence ID" value="ABB33683"/>
        <property type="gene ID" value="Gmet_3475"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3475"/>
    <dbReference type="eggNOG" id="COG1100">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077110_0_0_7"/>
    <dbReference type="OMA" id="RTLFFDM"/>
    <dbReference type="OrthoDB" id="1438064at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="225" mass="25134" checksum="219492EBB5EA281F" modified="2005-11-22" version="1">MIEYDEAQKKMVLKLVYYGPAMSGKTTNLLKLHDLITQEGRGELMVLDTTDDRTIFFDLLPFFLVAPSGLKIKVKVYTVPGQVRHDATRKAVLQRADGVVFVADSQLSEAANNFESFDNLEKNLAFVGIDIEKVPLVIQFNKRDLTNIVSEEEIARVWEPTGIQVTGASALEGWGVVETFTRLLELTYAAIDRKYRLLDEHGLGSESFVRKMTSVEATQGIAGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q10</accession>
    <name>Q39Q10_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_3455</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366195.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3455"/>
    <dbReference type="EnsemblBacteria" id="ABB33664">
        <property type="protein sequence ID" value="ABB33664"/>
        <property type="gene ID" value="Gmet_3455"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3455"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="YSIVMAN"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="108"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="257"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="472" mass="52938" checksum="7602EF436D6C6A2B" modified="2005-11-22" version="1">MPSGCPAMSEHQPQTSGTITARVPDGPAAELAQLKEENARLRARLASKSDYIRRKVDQMLTVMGTRPLRQEELDDNTLIDVDPLGILVDSFAHILDHLHTTNRELTENRELLQTIFSSLESGILLIREEDHVITDVNETACRSLGLKREDILGQLCFSFIYPDCTGACPMKEQNLKIDNSERMLRAADGHIVPVLKTVGRVMVHGIPHFLESFIDITAQKEAEAEILALNDDLEMRVQERTAELIQANREMESFSYSISHDLRAPLRHINGYINILREDYGGHLDMAGINCLQRVDAASKQMGMLIDDLLSFSRIPRTLKNPQTVDLSQLARDVTVMLRETEPDRQVEVEIQDGLVAHGDVSLLNMVVQNLIGNAWKFTARSSRAAISFGRKRQGERDVFFVLDNGVGFDMTYQNKLFKVFERLNGEEFEGTGIGLAIVKRIVNRHGGDIWAESSPGNGATFYFTLASPRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q37</accession>
    <name>Q39Q37_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heterodisulfide oxidoreductase, CCG domain pair-containing subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hdrB</name>
        <name evidence="2" type="ordered locus">Gmet_3425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514232.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3425"/>
    <dbReference type="EnsemblBacteria" id="ABB33637">
        <property type="protein sequence ID" value="ABB33637"/>
        <property type="gene ID" value="Gmet_3425"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3425"/>
    <dbReference type="eggNOG" id="COG2048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052147_1_0_7"/>
    <dbReference type="OMA" id="PGCVAQG"/>
    <dbReference type="OrthoDB" id="647535at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="10"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="CCG" evidence="1">
        <location>
            <begin position="151"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="296" mass="31858" checksum="7B1334BF3115519A" modified="2005-11-22" version="1">MTPAKKLLSYSYYPGCSLHASAKEYDESTRGLFKALGIGLQEVPDWLCCGATPAHNVDELLSLSLCAKNLSLAEGVEGDLAVACAACFSRLKVTQHHLADNETKRKQVEYAIDGTVNLAKPVKHLLEILAKDFGLDRLTEAVQKPLAGLKVACYYGCLLTRPPEVPQLDCVEAPTIMERVIGAVGAETVGWSHRMECCGANFTLSRPGVVLKLSGSILDSAKAAGADCLMVACPLCHGNLDIRQKEIEEATGQRFGMPVFYMTQLLALAVGVAPGKLGFDSMIVNPLPLLREKQLL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q56</accession>
    <name>ATPB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit beta</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpD</name>
        <name type="ordered locus">Gmet_3406</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514213.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Q56"/>
    <dbReference type="SMR" id="Q39Q56"/>
    <dbReference type="STRING" id="269799.Gmet_3406"/>
    <dbReference type="EnsemblBacteria" id="ABB33618">
        <property type="protein sequence ID" value="ABB33618"/>
        <property type="gene ID" value="Gmet_3406"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3406"/>
    <dbReference type="eggNOG" id="COG0055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022398_0_2_7"/>
    <dbReference type="OMA" id="GFNMIMD"/>
    <dbReference type="OrthoDB" id="430176at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000254268" description="ATP synthase subunit beta">
        <location>
            <begin position="1"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="157"/>
            <end position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01347"/>
        </source>
    </evidence>
    <sequence length="470" mass="51033" checksum="E10E8B7161CE1BC2" modified="2005-11-22" version="1">MSQNFGRISQVIGAVIDVEFEPGKLPPIYNALRVTNPAIDDKEYNLVLEVAQHLGENSVRTIAMDSTDGLVRGQAALDTGKQISVPVGRKTLGRILNVIGEPVDEMGPVNAEKEYGIHRESPSFVDQSTKVEAFTTGIKVVDLLAPYARGGKIGLFGGAGVGKTVLIMELINNIAKQHGGFSVFAGVGERTREGNDLWMEMKESGVLDKAALVYGQMNEPPGARARVALSALSIAEYFRDEEGQNVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATEMGELQERITSTTKGSITSVQAIYVPADDLTDPAPATAFAHLDATTVLSRQIAELGIYPAVDPLDSTSRILDPQVIGEEHYAIARQVQYVLQKYKDLQDIIAILGMDELSEEDKLVVARARKIQRFLSQPFHVAEAFTGSPGKYVELKDTIKGFQEIVAGKHDDIPEQAFYMVGTIEEALEKAKKLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QB8</accession>
    <name>Q39QB8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="18">NADH dehydrogenase I, L subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">nuoL-1</name>
        <name evidence="18" type="ordered locus">Gmet_3344</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a plastoquinone + (n+1) H(+)(in) + NADH = a plastoquinol + n H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:42608"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a plastoquinone + (n+1) H(+)(in) + NADPH = a plastoquinol + n H(+)(out) + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:42612"/>
            <dbReference type="Rhea" id="RHEA-COMP:9561"/>
            <dbReference type="Rhea" id="RHEA-COMP:9562"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17757"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62192"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Membrane</location>
            <topology evidence="3 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I subunit 5 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512570.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3344"/>
    <dbReference type="EnsemblBacteria" id="ABB33556">
        <property type="protein sequence ID" value="ABB33556"/>
        <property type="gene ID" value="Gmet_3344"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3344"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_0_7"/>
    <dbReference type="OMA" id="FWFTRIA"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002128">
        <property type="entry name" value="NADH_UbQ_OxRdtase_chlpt_su5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01010">
        <property type="entry name" value="Proton_antipo_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0618">Plastoquinone</keyword>
    <keyword evidence="6" id="KW-0874">Quinone</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="16">
        <location>
            <begin position="71"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="15">
        <location>
            <begin position="138"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_C" evidence="17">
        <location>
            <begin position="470"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB33556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="669" mass="73279" checksum="4EBB9BFD4F16EFF6" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QC2</accession>
    <name>FMT_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fmt</name>
        <name type="ordered locus">Gmet_3339</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N-formyl-L-methionyl-tRNA(fMet)</text>
            <dbReference type="Rhea" id="RHEA:24380"/>
            <dbReference type="Rhea" id="RHEA-COMP:9952"/>
            <dbReference type="Rhea" id="RHEA-COMP:9953"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:78844"/>
            <dbReference type="EC" id="2.1.2.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Fmt family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512564.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QC2"/>
    <dbReference type="SMR" id="Q39QC2"/>
    <dbReference type="STRING" id="269799.Gmet_3339"/>
    <dbReference type="EnsemblBacteria" id="ABB33552">
        <property type="protein sequence ID" value="ABB33552"/>
        <property type="gene ID" value="Gmet_3339"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3339"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_1_1_7"/>
    <dbReference type="OMA" id="CCPVVAY"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08704">
        <property type="entry name" value="Met_tRNA_FMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00182">
        <property type="entry name" value="Formyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005794">
        <property type="entry name" value="Fmt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037022">
        <property type="entry name" value="Formyl_trans_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044135">
        <property type="entry name" value="Met-tRNA-FMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00460">
        <property type="entry name" value="fmt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000020069" description="Methionyl-tRNA formyltransferase">
        <location>
            <begin position="1"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>(6S)-5,6,7,8-tetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00182"/>
        </source>
    </evidence>
    <sequence length="311" mass="33905" checksum="300A6A35D93D3390" modified="2005-11-22" version="1">MAGLSIIFMGTPDFACPTLTRLIERGEDVIAVVTQPDRPKGRGQKLVPPPVKVIAEEHGIPVLQPQKVRAPEVVAQIRELNPDLIVVVAFGQILPQSLLEIPRHGCINIHASLLPRYRGAAPINWCLINGETETGITTMQMDAGLDTGDMLVKRSISIGPDEDAQSLHDRLSLLGAETIDETLDRLQVGTLTREKQDDALTCYAPMLKKEDGLIDWKQEPQQIKNLVRGFTPWPGAYTTLDGKTLKLYKVSVATECGKPGDIMAVGKDGIIVGCGSGSLRIEELQLEGRKRLSAQDFLAGCRLEPGIRLGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QF0</accession>
    <name>Q39QF0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion system protein TssK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tssK</name>
        <name evidence="1" type="ordered locus">Gmet_3311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512535.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3311"/>
    <dbReference type="EnsemblBacteria" id="ABB33524">
        <property type="protein sequence ID" value="ABB33524"/>
        <property type="gene ID" value="Gmet_3311"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3311"/>
    <dbReference type="eggNOG" id="COG3522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031690_3_1_7"/>
    <dbReference type="OMA" id="VHPWQVY"/>
    <dbReference type="OrthoDB" id="496911at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010263">
        <property type="entry name" value="T6SS_TssK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35566">
        <property type="entry name" value="PTHR35566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05936">
        <property type="entry name" value="T6SS_VasE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03353">
        <property type="entry name" value="VI_chp_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="463" mass="52141" checksum="797657726E5921A4" modified="2005-11-22" version="1">MTAHPPVHWHQGLFLQPQHFQLLDLSIQGRLAPLFSYLHPHFWGAGELEIEESALGTGIFSILSGEFLFPDGTWAVLGENALCEPRSFDSAWLEGDKPLMVSVGIRKWQEAGENVTTVERLEGLSAVSTRFAAPMDPEEARDLHAGGPPGQVKRLRHMIKIFWDSEREQLGDWHLIPVARLERFGAEVRLSRRFIPPSLALEASEPLFRIIREIRDQVAARGRQLEEHKKQRGIQNAEFGSRDLVYLLALRSLNRHVPYLFHLTEARRVHPWDAYGALRQLIGELASFSERVSALGELDDGVRLLPPYDHRALGECFAGARDLIAQLLDEITAGPNYVIRLLHDGTFFSAELKPAVFDGGSRYYLALRTKEEPTTFLPSLETSAKLSAREHLPVLASRALPGIELAHMPVPPQELPRRSDTHYFAVDAAGDQWPLVEREHTLALYWTSAPADLEVELMVVARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QK6</accession>
    <name>Q39QK6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3255</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512693.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3255"/>
    <dbReference type="EnsemblBacteria" id="ABB33468">
        <property type="protein sequence ID" value="ABB33468"/>
        <property type="gene ID" value="Gmet_3255"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3255"/>
    <dbReference type="HOGENOM" id="CLU_174771_2_0_7"/>
    <dbReference type="OMA" id="SKNCMNQ"/>
    <dbReference type="OrthoDB" id="1980455at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223264" evidence="2">
        <location>
            <begin position="23"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="93" mass="10280" checksum="77645371F44A08F8" modified="2005-11-22" version="1">MKKMAVLLMAAFMMSATVPVFAAEMTKEEKDQCLLASKNCGMEVDTLQKKIKKLNSEIKKGKKVYSADEIKKLQQKLDEANALLDDILKGGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QL9</accession>
    <name>Q39QL9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferritin-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33455.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512680.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3242"/>
    <dbReference type="DNASU" id="3740958"/>
    <dbReference type="EnsemblBacteria" id="ABB33455">
        <property type="protein sequence ID" value="ABB33455"/>
        <property type="gene ID" value="Gmet_3242"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3242"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119858_2_0_7"/>
    <dbReference type="OMA" id="YAIKEEQ"/>
    <dbReference type="OrthoDB" id="1590143at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33455.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="17545" checksum="2962B1A7858B6F95" modified="2012-10-31" version="2">MEFKTLDDIIKFAVEREENAYQLYKTAAQKATSISARKMFEEMANEEAGHKTAFERLDIEGAEKYSLADRPDMKIAEYMVEMPFRDDMSYPEILRYAMKTEENAYKLYTAAAELTDDPKFKRMLLVLADIEKGHKQKIEAVYDERVLTEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QN0</accession>
    <name>Q39QN0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Precorrin-2 dehydrogenase</fullName>
            <ecNumber evidence="3">1.3.1.76</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cysG</name>
        <name evidence="8" type="ordered locus">Gmet_3231</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin</text>
            <dbReference type="Rhea" id="RHEA:15613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58351"/>
            <dbReference type="ChEBI" id="CHEBI:58827"/>
            <dbReference type="EC" id="1.3.1.76"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; siroheme biosynthesis; sirohydrochlorin from precorrin-2: step 1/1.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.76" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512670.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3231"/>
    <dbReference type="EnsemblBacteria" id="ABB33444">
        <property type="protein sequence ID" value="ABB33444"/>
        <property type="gene ID" value="Gmet_3231"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3231"/>
    <dbReference type="eggNOG" id="COG1648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_8_1_7"/>
    <dbReference type="OMA" id="STQIWKL"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00222"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043115">
        <property type="term" value="F:precorrin-2 dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028161">
        <property type="entry name" value="Met8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042518">
        <property type="entry name" value="SirC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028281">
        <property type="entry name" value="Sirohaem_synthase_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006367">
        <property type="entry name" value="Sirohaem_synthase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35330">
        <property type="entry name" value="PTHR35330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14824">
        <property type="entry name" value="Sirohm_synth_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01470">
        <property type="entry name" value="cysG_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sirohm_synth_M" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="224" mass="23959" checksum="63112B1B24061086" modified="2005-11-22" version="1">MSQFPVNLNLRERNAVIVGGGAVAARKCLLLMEAGARVTVIAPRLDPRLEELRREGWIICHARQYGEGDLADAFLAFAATDNPAVNLHVARDAAALGILVDITGAPEHGSFTTPAHFRRGDLLVAVSTGGKSPALAQSICNDLAQRFGPEYAETVAILGAVREKLLTVRGNRTYNKAVLRTLADADLPGLIRRGEYETIDRLLVTHAGPGFTLASLGTRTEDPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R25</accession>
    <name>Q39R25_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Sensor diguanylate cyclase/phosphodiesterase, PAS, PAS and PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_3085</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514539.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3085"/>
    <dbReference type="EnsemblBacteria" id="ABB33299">
        <property type="protein sequence ID" value="ABB33299"/>
        <property type="gene ID" value="Gmet_3085"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3085"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_70_20_7"/>
    <dbReference type="OMA" id="IGMTRNI"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01948">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012226">
        <property type="entry name" value="Diguanyl_cyclase/Pdiesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005925">
        <property type="entry name" value="Dos"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50883">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="158"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="209"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="281"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="2">
        <location>
            <begin position="330"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="3">
        <location>
            <begin position="404"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="491"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="EAL" evidence="4">
        <location>
            <begin position="633"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="905" mass="100777" checksum="2EF9B80E726C14BF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R71</accession>
    <name>Q39R71_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Efflux pump, RND family, membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_3038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514352.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3038"/>
    <dbReference type="EnsemblBacteria" id="ABB33253">
        <property type="protein sequence ID" value="ABB33253"/>
        <property type="gene ID" value="Gmet_3038"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3038"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_14_1_7"/>
    <dbReference type="OMA" id="FYVIANP"/>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043602">
        <property type="entry name" value="CusB_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00529">
        <property type="entry name" value="CusB_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223282" evidence="4">
        <location>
            <begin position="20"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="CusB_dom_1" evidence="5">
        <location>
            <begin position="52"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="6">
        <location>
            <begin position="56"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="313"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="96"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="403" mass="43579" checksum="184D4DE4E7E5FE7F" modified="2005-11-22" version="1">MKKFLIPAAAVLVVAGVAAYFTLNKKPETVFKTAKIERGDIVSTVSATGNLAAVVTVQVGTQVSGTIQKLFVDYNSPVKKGQVIAQIDPSLFSAQVEQTRGNYLNAQANLQRVRADLADARRNQERNRQLLKDGVVSQSDFDAADNRYQMAQATVKAAEGSVAQTRGAFSQSETNLRYATIRSPVDGIVVSRNVDVGQTVAASFQTPTLFTIAQDLTRMEIDTSVDEADISRVQVGQPVSFTVDSYPENRFTGTVRQVRNAPVVTQNVVTYVVVIDVDNKDMKLKPGMTANVSIETARKDNVLKLPSAALRFRPKKGGDEKAAKGQQAGQEQRRKKREGGQQVYILGAENKPVPVPVKTGIGNDGQVELVSGNLKENDQVIIEQVTPQQKKAGGMGGSMGPRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R76</accession>
    <name>TRUD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA pseudouridine synthase D</fullName>
            <ecNumber evidence="1">5.4.99.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridine(13) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA pseudouridylate synthase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-uridine isomerase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">truD</name>
        <name type="ordered locus">Gmet_3033</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>uridine(13) in tRNA = pseudouridine(13) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:42540"/>
            <dbReference type="Rhea" id="RHEA-COMP:10105"/>
            <dbReference type="Rhea" id="RHEA-COMP:10106"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.27" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514347.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39R76"/>
    <dbReference type="SMR" id="Q39R76"/>
    <dbReference type="STRING" id="269799.Gmet_3033"/>
    <dbReference type="EnsemblBacteria" id="ABB33248">
        <property type="protein sequence ID" value="ABB33248"/>
        <property type="gene ID" value="Gmet_3033"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3033"/>
    <dbReference type="eggNOG" id="COG0585">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005281_4_0_7"/>
    <dbReference type="OMA" id="LWLWVEK"/>
    <dbReference type="OrthoDB" id="1490777at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106029">
        <property type="term" value="F:tRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01082">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020119">
        <property type="entry name" value="PsdUridine_synth_TruD_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01268">
        <property type="entry name" value="UPF0024"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000230140" description="tRNA pseudouridine synthase D">
        <location>
            <begin position="1"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="TRUD" evidence="1">
        <location>
            <begin position="154"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01082"/>
        </source>
    </evidence>
    <sequence length="404" mass="44283" checksum="C53FD86510BDA646" modified="2005-11-22" version="1">MSGEKRYLTAGLPGTGGTIKETADDFVVEEIPLYLPCGEGEHVYALIEKRGVTTLDAIRRLARALKLSERDVGYAGMKDARGVTRQTVSLPRMKPEEVLALELPGIRILSAERHRNKLKLGHLAGNRFRIRVRGVVSDAVARAEAILAVLERRGVPNRFGEQRYGAQGNSHLIGRAMLAGDWCAAVDLLMGDPAKVTGEAWRSAIEAYQRGELEESQRLFPGHCRTERDVIQRLVKRPDDFEGAFRAVNPRLRKLYLSACQSALFDHVVEARLDSLDTVQEGDLAWKHANGACFLVTDPAAEAPRAEHFEISPTGPLFGCRMMMPEGEEGALERSLLAAEGVEPASFDLPGGLRMEGERRPLRVPLGDPRASADADGLVLEFSLPKGSYATAVLREVMKGGRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R98</accession>
    <name>Q39R98_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glyoxalate/3-oxopropanoate/4-oxobutanoate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ghr</name>
        <name evidence="5" type="ordered locus">Gmet_3011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="journal article" date="2014" name="Biochimie" volume="104" first="61" last="69">
            <title>Structural characterization of a beta-hydroxyacid dehydrogenase from Geobacter sulfurreducens and Geobacter metallireducens with succinic semialdehyde reductase activity.</title>
            <authorList>
                <person name="Zhang Y."/>
                <person name="Zheng Y."/>
                <person name="Qin L."/>
                <person name="Wang S."/>
                <person name="Buchko G.W."/>
                <person name="Garavito R.M."/>
            </authorList>
            <dbReference type="PubMed" id="24878278"/>
            <dbReference type="DOI" id="10.1016/j.biochi.2014.05.002"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS) IN COMPLEX WITH NADP</scope>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514324.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="3PEF">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.07 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=1-287"/>
    </dbReference>
    <dbReference type="PDBsum" id="3PEF"/>
    <dbReference type="SMR" id="Q39R98"/>
    <dbReference type="STRING" id="269799.Gmet_3011"/>
    <dbReference type="EnsemblBacteria" id="ABB33226">
        <property type="protein sequence ID" value="ABB33226"/>
        <property type="gene ID" value="Gmet_3011"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3011"/>
    <dbReference type="eggNOG" id="COG2084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035117_0_0_7"/>
    <dbReference type="OMA" id="AWVQSTT"/>
    <dbReference type="OrthoDB" id="1194694at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016054">
        <property type="term" value="P:organic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="NADP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD_binding_2" evidence="3">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="NAD_binding_11" evidence="4">
        <location>
            <begin position="165"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="32"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>NADP</name>
            <dbReference type="ChEBI" id="CHEBI:44409"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="3PEF"/>
        </source>
    </evidence>
    <sequence length="287" mass="29869" checksum="DCC6EB3ECE85A023" modified="2005-11-22" version="1">MQKFGFIGLGIMGSAMAKNLVKAGCSVTIWNRSPEKAEELAALGAERAATPCEVVESCPVTFAMLADPAAAEEVCFGKHGVLEGIGEGRGYVDMSTVDPATSQRIGVAVVAKGGRFLEAPVSGSKKPAEDGTLIILAAGDRNLYDEAMPGFEKMGKKIIHLGDVGKGAEMKLVVNMVMGGMMACFCEGLALGEKAGLATDAILDVIGAGAMANPMFALKGGLIRDRNFAPAFPLKHMQKDLRLAVALGDRVGQPLVASAAANELFKGARAAGFGDEDFSAIFKTIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RK0</accession>
    <name>Q39RK0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2906</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33124.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2906"/>
    <dbReference type="EnsemblBacteria" id="ABB33124">
        <property type="protein sequence ID" value="ABB33124"/>
        <property type="gene ID" value="Gmet_2906"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2906"/>
    <dbReference type="eggNOG" id="COG3894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019091_1_0_7"/>
    <dbReference type="OMA" id="IRTDLCD"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027980">
        <property type="entry name" value="RACo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041414">
        <property type="entry name" value="Raco_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042259">
        <property type="entry name" value="Raco_middle_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14574">
        <property type="entry name" value="RACo_C_ter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17651">
        <property type="entry name" value="Raco_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Raco_middle" evidence="2">
        <location>
            <begin position="8"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="RACo_C_ter" evidence="1">
        <location>
            <begin position="173"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33124.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="422" mass="43710" checksum="E9579586101566E8" modified="2012-10-31" version="2">MSSPDRLAIAVDLGTTTLAASLLDMATGERLAVAGSLNPQREFGADVIARLDAACRSKEARHRMAELVRGAIGRLAGELLESVGRSPEHLVTIAVAGNPAMEHLLLDLPVDALAFPPYRPLFTAGKTVPAVGLGWDLPAEVFLFPLPGGFVGGDTVAFLHGVPGPRSPVPGPRLYLDMGTNGEIALAADGKLLATSAAAGPAFEGGNLSCGMAALPGAISGVTFDGERLLVSTVEGKPATGICGSGVLSAIALLLDQGAIDSTGRLLPPEEIPSSIGNRLTTMGDERAFVLHRDATRTVWLSQEDIRQVQLAKGAIRAGMEVLFDRAGIESGAVGSVVLTGSFGAVLDPHSLKSLGVFTENMVQTTSFVREGALRGVEHALLTSGGLAAVDHLAGTIRVIPLSGTPAFEKHFLQHINFPHTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RN1</accession>
    <name>Q39RN1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514606.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2875"/>
    <dbReference type="EnsemblBacteria" id="ABB33093">
        <property type="protein sequence ID" value="ABB33093"/>
        <property type="gene ID" value="Gmet_2875"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2875"/>
    <dbReference type="eggNOG" id="COG5512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134901_0_0_7"/>
    <dbReference type="OMA" id="LCEYLAM"/>
    <dbReference type="OrthoDB" id="1918294at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007922">
        <property type="entry name" value="DUF721/UPF0232"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05258">
        <property type="entry name" value="DciA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="162" mass="18046" checksum="D75C189173EDE112" modified="2005-11-22" version="1">MGNARSRMTRPRPVADLLTEALRGKPAERRLKEGRIWLLWDEAVGERIASVARPVGFRGGTLTVAVANAPWMQQLNFLKQGIMDKLNALLCGPVVTEIYLKAGRTEPPPAPSSEQRPPVRELTTVEKEFVREETESIEDPELRAIISRLMARHLASSPPDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RR8</accession>
    <name>Q39RR8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA pseudouridine synthase, RluA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513965.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2838"/>
    <dbReference type="EnsemblBacteria" id="ABB33056">
        <property type="protein sequence ID" value="ABB33056"/>
        <property type="gene ID" value="Gmet_2838"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2838"/>
    <dbReference type="eggNOG" id="COG0564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016902_8_2_7"/>
    <dbReference type="OMA" id="PKTHVYR"/>
    <dbReference type="OrthoDB" id="1714699at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120159">
        <property type="term" value="F:rRNA pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd02869">
        <property type="entry name" value="PseudoU_synth_RluA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="SSF55120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PseudoU_synth_2" evidence="1">
        <location>
            <begin position="87"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="296" mass="32067" checksum="2A3C927A7F857FC3" modified="2005-11-22" version="1">MLTFTITESDHCRGVESFLRNLLPGAPLAYLGKLTRGGHLTVNGLPVTPDTLLVTGDTMALKESGRTRELLAAKRPSLDILFEDDRIVVVNKPPGLPVHRTAEDEQTLVDVAERFLAQRGTPAKLRPVNRLDRGTSGATILAKSATSAGMFGRFVKETGLGKLYLAVADGKLPAEGTIDTPLEGKEAQTQYRTLFQGKSAALLLVTPITGRTHQIRKHLALTGHPVRGDRRYRGAPLAAYPGHCLHAFLVSFRHPVSGEEIVIHAPLPAALLEEVRLLSGDFYSRILLSLPSLPVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RS0</accession>
    <name>Q39RS0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2836</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2836"/>
    <dbReference type="EnsemblBacteria" id="ABB33054">
        <property type="protein sequence ID" value="ABB33054"/>
        <property type="gene ID" value="Gmet_2836"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2836"/>
    <dbReference type="eggNOG" id="COG3170">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073797_3_1_7"/>
    <dbReference type="OMA" id="FRIHYGI"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021457">
        <property type="entry name" value="DUF3108"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11306">
        <property type="entry name" value="DUF3108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="237" mass="26813" checksum="E43F1E8FA9EFFD6D" modified="2005-11-22" version="1">MFLVLVTSGVPASAAPKVPEKLVYNLSWTGISVGTASQEITEEGATRKIVSIARSNDWLSTFFPVEDRIESSYDSSRGNFPGQARHYRLKTREGSRHRDREIFFEQERGVARYRDNLSGDKADIDIPLDTIDVYGSFYYIRYLRLEVGKSPTVNILDSKRQRRIAVRVLRKERIKTVLGEVDTIVIQPLVASEGVFEGKGTVHIWLTDDERRIPVRARTKVTVGSVTATLVEWIPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RS1</accession>
    <name>Q39RS1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitroreductase-like family 3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2012-02" db="PDB data bank">
            <title>CRYSTAL STRUCTURE OF putative Nitroreductase from Geobacter metallireducens GS-15.</title>
            <authorList>
                <person name="Malashkevich V.N."/>
                <person name="Bhosle R."/>
                <person name="Toro R."/>
                <person name="Seidel R."/>
                <person name="Almo S.C."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.50 ANGSTROMS) IN COMPLEX WITH FMN</scope>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513968.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="4DN2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.50 A"/>
        <property type="chains" value="A/B=1-186"/>
    </dbReference>
    <dbReference type="PDBsum" id="4DN2"/>
    <dbReference type="SMR" id="Q39RS1"/>
    <dbReference type="STRING" id="269799.Gmet_2835"/>
    <dbReference type="EnsemblBacteria" id="ABB33053">
        <property type="protein sequence ID" value="ABB33053"/>
        <property type="gene ID" value="Gmet_2835"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2835"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_1_7"/>
    <dbReference type="OMA" id="HPYAKML"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:17621"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="4DN2"/>
        </source>
    </evidence>
    <sequence length="186" mass="20456" checksum="148A84A6F14C362C" modified="2005-11-22" version="1">METLEAIRTRRSVRKFSDRPVEPEKLRAVLDAARLAPSWANMQCWRFVVVEDQATKVQISELSYVEAYFGPKGYKSNPAQKALAEAPVVIIACGEPPQSGELRGQQYYLTDVGIAAQNLMLAAHDLGLGSVFVGVFDEQQLGELLGIPAELRIVGLFPLGYPLEGPKAGPSRKPLDEIVHYGKYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RW9</accession>
    <name>Q39RW9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511675.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2787"/>
    <dbReference type="EnsemblBacteria" id="ABB33005">
        <property type="protein sequence ID" value="ABB33005"/>
        <property type="gene ID" value="Gmet_2787"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2787"/>
    <dbReference type="eggNOG" id="COG1915">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056125_0_0_7"/>
    <dbReference type="OMA" id="GHKHHIY"/>
    <dbReference type="OrthoDB" id="718059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="364" mass="39755" checksum="563236A3A65B9387" modified="2005-11-22" version="1">MPPFPPYIPPDFTRPDLAAAPPASTEKAPRDGVLPAGFHATSNHPEYVHLGGGRWLLAVESRMDAVLVLEDEGVRVVEPRLVREGERVVMGRAENGEDGIYVHTTGFEPLADASSGDKFGFRSRGTRETPFSRSYDELYDILRHDRDNGSIVWVLGPAVAFDRDSRDAMASLVGAGYCHALLAGNALATHDLEAAFFHTGLGQDIYTQALVPRGHYNHLDVINEVLRHGSLERAMAELGIGDGIIRACLERRVPVVLAGSIRDDGPLPEVITDSGRAQDAMRVHARRATTVIALATQLHAIAVGNMTPGYRVMDDGTVRPVYFYVVDMSEFIADKLANRGSAQARAILTNAQDFMVNLWHNLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RY6</accession>
    <name>Q39RY6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366098.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2770"/>
    <dbReference type="EnsemblBacteria" id="ABB32988">
        <property type="protein sequence ID" value="ABB32988"/>
        <property type="gene ID" value="Gmet_2770"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2770"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_71_7"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="208"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="418" mass="46089" checksum="E4FDDC17F50E5BFC" modified="2005-11-22" version="1">MAICRNEVRMRGDKRGKIAIAKQMANRLYPLALAIALLIGIGFPAVYAILAAEVQMNTATCHAGELAERLGKMAREDITLWKFQNQKYAAVLDDFLPRKNIMHVRILDESGKALTIFDRVEAHGIPIFRPLALSSEAPIVFNRQTIGTVVIETASDRLILSTFAVFLFFAVVGLVLAVSVYHYPTRVAKGLEGEIGGLIAELESFSYTVSHDLHAPLRHISGYSGILLEDHGDRLGPDVREMLSRIHGSSERMKEIVDSLLELSRIGRTELKRERVNLGTIAHDITERLKLSGAGRQATFRIQDNVVVEGDPHLLRNVLENLLGNAWKFTAKRDIAVIEFGTVEVDGSEACFVRDNGAGFDMAYADKLFAPFQRLHSAAEFEGSGIGLATVRRIINHHGGNLWAEGTPGEGAAFYFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RZ3</accession>
    <name>Q39RZ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aconitate hydratase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511698.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2763"/>
    <dbReference type="EnsemblBacteria" id="ABB32981">
        <property type="protein sequence ID" value="ABB32981"/>
        <property type="gene ID" value="Gmet_2763"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2763"/>
    <dbReference type="eggNOG" id="COG1048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006714_2_3_7"/>
    <dbReference type="OMA" id="GCIGMGQ"/>
    <dbReference type="OrthoDB" id="363064at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006250">
        <property type="entry name" value="Aconitase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01342">
        <property type="entry name" value="acon_putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase" evidence="5">
        <location>
            <begin position="8"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_C" evidence="6">
        <location>
            <begin position="519"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="648" mass="69974" checksum="0DC067184AB6D475" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S33</accession>
    <name>Q39S33_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peroxiredoxin, typical 2-Cys subfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">prx-1</name>
        <name evidence="3" type="ordered locus">Gmet_2723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32941.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511737.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2723"/>
    <dbReference type="EnsemblBacteria" id="ABB32941">
        <property type="protein sequence ID" value="ABB32941"/>
        <property type="gene ID" value="Gmet_2723"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2723"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_3_7"/>
    <dbReference type="OMA" id="CPLGWKP"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223318" evidence="1">
        <location>
            <begin position="24"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="53"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32941.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="223" mass="24505" checksum="47D12968DF1C0423" modified="2012-10-31" version="2">MNRITALLAAILATSLFAGPACAAPEKADDMTKATELMVQHHKGMVRTAPEMAKVGEPAPPFTLDAVVDKEFKKVSLGDYRGKWVVLFFYPADFTFVCPTEITGFNKAMDRFTELNAQLLGASVDSKYSHLAWIKRGDLGDLKYPLLADNKKEATARYGILDEKEGVALRGLFIIDPNGVLQYQVVNNLSVGRSVDETLRVLEALQTGELCPLGWKPGEKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S38</accession>
    <name>Q39S38_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein 3-oxoalanine-generating enzyme family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511742.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2718"/>
    <dbReference type="EnsemblBacteria" id="ABB32936">
        <property type="protein sequence ID" value="ABB32936"/>
        <property type="gene ID" value="Gmet_2718"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2718"/>
    <dbReference type="eggNOG" id="COG1262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012431_2_3_7"/>
    <dbReference type="OMA" id="YEWTADC"/>
    <dbReference type="OrthoDB" id="1377603at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="SSF56436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223037" evidence="1">
        <location>
            <begin position="25"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="FGE-sulfatase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="292" mass="31971" checksum="7A401A3716F18BDA" modified="2005-11-22" version="1">MMNTHRLATGAALLAFLVIVSPLAAEVKPAAKVSSPPPAAGSVFRDRLKNGSSGPEMVVIPAGKFRMGAIFGGGDPDEKPVHWVSIARPFAMGKYEVTFGEYDRFCDATGREKPKDGRRWFGPLSRDWGRGRMPAMNVSWEDAVAYAKWLSEQTGQKYRLPSEAEWEFAARGGKDTPFWWGGTAGEKRANCKGCGSKWDNKKGAPAGSFAANPYGLFDTAGNVWEWCLDTWHDSYTGAPTDGSPWLGGDDTRRVQRGGSFGSKVRYIRSSARGRGAPDGQYVYLGFRVLREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S50</accession>
    <name>Q39S50_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Scaffold protein CheW associated with MCPs of class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheW40H-4</name>
        <name evidence="2" type="ordered locus">Gmet_2706</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366087.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2706"/>
    <dbReference type="EnsemblBacteria" id="ABB32924">
        <property type="protein sequence ID" value="ABB32924"/>
        <property type="gene ID" value="Gmet_2706"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2706"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_3_1_7"/>
    <dbReference type="OMA" id="VRMVEIT"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="155" mass="17063" checksum="5D7B8386CCD7D895" modified="2005-11-22" version="1">MSESCHLVIFTLDDQRYALHLSAVDRTVRMVEITPLPKAPGIVLGVISVNGMIVPVLDIRRRFALPERKTGLGDHLVIARTAKRTVALAVNGVHEVIERPAGEIIPPEAVLPGMEHVHGVVKLEDGMVFIHDLDGFLSLEEEQVLDAAMEQERHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SF7</accession>
    <name>Q39SF7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ech-hydrogenase-related complex, HyfF-like integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ehrD-1</name>
        <name evidence="4" type="ordered locus">Gmet_2598</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511863.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2598"/>
    <dbReference type="EnsemblBacteria" id="ABB32817">
        <property type="protein sequence ID" value="ABB32817"/>
        <property type="gene ID" value="Gmet_2598"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2598"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_10_1_7"/>
    <dbReference type="OMA" id="YIFIAST"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="442"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="114"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="478" mass="51178" checksum="4A3BC39D3EF01E7B" modified="2005-11-22" version="1">MLYALVLLPLVGALCAWIVPDNRLRPITLPAVATVHLALTALLLVNTPPPSPGGWIWLDPLGKVVLLCISLLFTVCAYYAVGYLSYRQERSNRVLCMGLLVCLSAMGLVTMTQHLGLLWVALETTTVSMAPLIYFNRNARSIEATWKYLLLCSVGIGLALLGLLFLAYSTYVAHRDATLLLGPLMQSARELNPGWLHAAAIFLLVGYGSKMGLAPLHAWKPDAYGEAPGLVGALLAGGLVNCAFLCIMRVYQICLASGAELAFFQDALVGMGLISMAFAAVFMAHQADFKRMLAYSSVEHVGILAIGLGLGKGALYGALFHLLNNGLTKGVLFLSSGNIHRSYGNKTTDVVRGALARLPWSGGLFLAGFIAITGSPPFSPFISEYAIVSNAFIDGRHLVGWLFLLFLVIVFIGMALTVLPMVMGTPPAGLEPSDYEDRLLTVGPPFLMMAVILLLGIWPPAFLVSLLTEGAAMLGVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SL5</accession>
    <name>Q39SL5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Histidine kinase-like ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2540"/>
    <dbReference type="EnsemblBacteria" id="ABB32759">
        <property type="protein sequence ID" value="ABB32759"/>
        <property type="gene ID" value="Gmet_2540"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2540"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_810728_0_0_7"/>
    <dbReference type="OMA" id="YAAHMGF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="342" mass="38120" checksum="F33B47B4C92D9ADD" modified="2005-11-22" version="1">MDNSVTVQVPARLDIENAISFIHQIYELPPAKEYIFDFILLSWVEPFALLYVSYHLANFLGDTPGITLKVARFNIYNAHLYAAHMGFFKSFGLDFGNNAGQAKGSAYYIPITIFNVDQIRSESHTEGVHIGDVLESKARDLAKMLTRRNDGDLVDTLEFSLREMFRNVVEHSGAKRIGICGQYWPTKHMVEIAILDNGIGIKESLKNNPFLLIETDKDALNCALLPGVSGKAYRGAKTNKGKGHWSNSGFGLFMTSELCRNGGSFFICSKSSGIMLRERSKRNVVTQLDGTALRLIIDTSSLRQVTESLSEFREKGYRIAKELNGAVIDPSAASLMLSRDFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SP3</accession>
    <name>Q39SP3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="3">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bkdA</name>
        <name evidence="3" type="synonym">pdhA</name>
        <name evidence="5" type="ordered locus">Gmet_2509</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>(R)-N(6)-lipoyl-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + H(+) + pyruvate = (R)-N(6)-(S(8)-acetyldihydrolipoyl)-L-lysyl-[dihydrolipoyllysine-residue acetyltransferase] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10480"/>
            <dbReference type="Rhea" id="RHEA-COMP:10481"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514777.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2509"/>
    <dbReference type="EnsemblBacteria" id="ABB32731">
        <property type="protein sequence ID" value="ABB32731"/>
        <property type="gene ID" value="Gmet_2509"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2509"/>
    <dbReference type="eggNOG" id="COG1071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029393_1_0_7"/>
    <dbReference type="OMA" id="GMFRGVN"/>
    <dbReference type="OrthoDB" id="1248201at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017596">
        <property type="entry name" value="PdhA/BkdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF41">
        <property type="entry name" value="PTHR11516:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03181">
        <property type="entry name" value="PDH_E1_alph_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="2 3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="E1_dh" evidence="4">
        <location>
            <begin position="43"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="352" mass="38846" checksum="DA66BFB70B7645E5" modified="2005-11-22" version="1">MPESILATFTVKRLEIIAPDGTADEDLVPGLSGDELRRIYYLLLLTRAYDGRALALQREGRLGTYPSVLGQEAAQVGSAFAIHERDWVFPSFREMGVHLTLGYPAHQLFQYWGGDERGMRTPDGMNIFPISVSVGTHIPHAAGAALAAKLRGDPIAVIAYFGDGGTSKGDFHEGFNLAGVMGLPTVFICQNNQWAISVPLSAQTASRSLAQKALAYGFDGIQVDGNDVLAVYRATREALEKARSGGGPTFIECLTYRMSDHTTSDDASRYRSPEEMEQWRERDPILRYERFLAKRGLWNEDYAAEMKGKAGGEIDEAVRRYESVPPPAPGEMFNFVSGELSARLRRQRETST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="48" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SR3</accession>
    <name>Q39SR3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4435 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366062.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32711">
        <property type="protein sequence ID" value="ABB32711"/>
        <property type="gene ID" value="Gmet_2486"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2486"/>
    <dbReference type="eggNOG" id="ENOG5033NT2">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_873638_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029492">
        <property type="entry name" value="DUF4435"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14491">
        <property type="entry name" value="DUF4435"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4435" evidence="1">
        <location>
            <begin position="34"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="318" mass="36302" checksum="CE4D2147C3D05C05" modified="2005-11-22" version="1">MIKYSGYEVAIYMSRLIHSNSGHIRSMQISNTQLFIFVEGKQSDPYFFAKVCKASLPDSIEFEISTAQQISGGAGGKEALISYFRCLRRKSALISFFEGKRTACIFILDKDIDDIKRKQLRSTHVIYTQYYDVQNYIFEHGDLVTGVAAAASIDPRKLHGVLGNSSEWCRRVSHLWRDWIALCFRLIEDGIRGEANYGAPSRIQTRNCGMTDTIALESLVRTLAQRTNISFDEMMRKVELSNKKIDRYFKTGQHHRIFKGKWFSLILADEVERIMTGQPHDCNGLAGRLPSTVAATINFNDPWIEYFKHRLCAVAAML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SS7</accession>
    <name>Q39SS7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">dTDP-4-dehydrorhamnose reductase</fullName>
            <ecNumber evidence="4 6">1.1.1.133</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">rmlD</name>
        <name evidence="8" type="ordered locus">Gmet_2472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>dTDP-beta-L-rhamnose + NADP(+) = dTDP-4-dehydro-beta-L-rhamnose + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21796"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57510"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="1.1.1.133"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate biosynthesis; dTDP-L-rhamnose biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the dTDP-4-dehydrorhamnose reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.133" evidence="4 6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512427.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2472"/>
    <dbReference type="EnsemblBacteria" id="ABB32697">
        <property type="protein sequence ID" value="ABB32697"/>
        <property type="gene ID" value="Gmet_2472"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2472"/>
    <dbReference type="eggNOG" id="COG1091">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045518_1_2_7"/>
    <dbReference type="OMA" id="AGETTWH"/>
    <dbReference type="OrthoDB" id="1076083at2"/>
    <dbReference type="UniPathway" id="UPA00124"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008831">
        <property type="term" value="F:dTDP-4-dehydrorhamnose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019305">
        <property type="term" value="P:dTDP-rhamnose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="PTHR10491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01214">
        <property type="entry name" value="rmlD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD_sub_bind" evidence="7">
        <location>
            <begin position="2"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="280" mass="30843" checksum="6F7AAAFE9695605D" modified="2005-11-22" version="1">MILVVGAKGMLGQDLMRVLPGDVRGVDIEEIDITSPESVRRVLLTLKPRVVVNCAAYTDVDGCETNVDLAMRVNGDGVGHLAAATREIGALLVQVSTDYVFDGTKGTPYVEDDRVNPLSVYGKSKLVGEKKARENPDHLIVRTQWLYGHGGKNFVETMLRLAGERTEIAVVDDQIGSPTWTADLSLAITELIENNCRGTYHAANRGTCSWYEFARAIFAEAGVGMTVRPQSTEELGRPAPRPLYSVLDCDKLTHDAGLELEDWREALKNYLERRQPAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SV8</accession>
    <name>Q39SV8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nickel ABC transporter, membrane protein NikMN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">nikMN</name>
        <name evidence="10" type="ordered locus">Gmet_2441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512459.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2441"/>
    <dbReference type="EnsemblBacteria" id="ABB32666">
        <property type="protein sequence ID" value="ABB32666"/>
        <property type="gene ID" value="Gmet_2441"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2441"/>
    <dbReference type="eggNOG" id="COG0310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052508_0_1_7"/>
    <dbReference type="OMA" id="LLLMQPI"/>
    <dbReference type="OrthoDB" id="1632785at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002751">
        <property type="entry name" value="CbiM/NikMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025937">
        <property type="entry name" value="PDGLE_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01891">
        <property type="entry name" value="CbiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13190">
        <property type="entry name" value="PDGLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PDGLE" evidence="9">
        <location>
            <begin position="233"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="346" mass="34703" checksum="64F880DC09E94433" modified="2005-11-22" version="1">MHMADALISPAVGGTLWVAAGGTIAYCARKVRQDLDERKVPLMGVLGAFVFAAQMINFTIPGTGSSGHLGGGLLLAVLLGPHAAFLTIASVLVVQALFFADGGLLALGCNIVNLGFFPAFVAYPLIYRAIAPAGSGQGRSTAAAVAAAVVGLQFGALSVVLETVASGISALPFSSFVLLMQPIHLAIGIVEGLVTAAVVGFVVKAHPEVIGATRRSVTSGSGFRWVAVSLLALAVITGGVVSRYASGKPDGLEWAIAGVTGKGELASPTGGVHGALAAIQKKSSSLPAYSFAKPTEDGAGEPAARKRGAAKGDDRLGTSVSGIAGGGLTLVMAFAVGFLLRRRAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SW9</accession>
    <name>Q39SW9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methyl-accepting chemotaxis sensory transducer, class 34H-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mcp34H-1</name>
        <name evidence="3" type="ordered locus">Gmet_2430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512470.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2430"/>
    <dbReference type="EnsemblBacteria" id="ABB32655">
        <property type="protein sequence ID" value="ABB32655"/>
        <property type="gene ID" value="Gmet_2430"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2430"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030861_0_0_7"/>
    <dbReference type="OMA" id="FVVIANE"/>
    <dbReference type="OrthoDB" id="220274at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="Methyl-accepting transducer" evidence="2">
        <location>
            <begin position="321"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="625" mass="66935" checksum="BE1C81E9AF9FFF38" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T21</accession>
    <name>Q39T21_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="9">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">serA</name>
        <name evidence="11" type="ordered locus">Gmet_2378</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 9">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 9">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514763.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2378"/>
    <dbReference type="EnsemblBacteria" id="ABB32603">
        <property type="protein sequence ID" value="ABB32603"/>
        <property type="gene ID" value="Gmet_2378"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2378"/>
    <dbReference type="eggNOG" id="COG0111">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019796_8_1_7"/>
    <dbReference type="OMA" id="NIAGMQV"/>
    <dbReference type="OrthoDB" id="1638924at2"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="SSF143548"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="456"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="541" mass="58806" checksum="FF720DAF982F8875" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="124" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T78</accession>
    <name>Q39T78_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine--tRNA ligase</fullName>
            <ecNumber evidence="7">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Methionyl-tRNA synthetase</fullName>
            <shortName evidence="7">MetRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">metG</name>
        <name evidence="11" type="ordered locus">Gmet_2321</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513299.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2321"/>
    <dbReference type="EnsemblBacteria" id="ABB32546">
        <property type="protein sequence ID" value="ABB32546"/>
        <property type="gene ID" value="Gmet_2321"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2321"/>
    <dbReference type="eggNOG" id="COG0143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009710_9_4_7"/>
    <dbReference type="OMA" id="SDMHGTP"/>
    <dbReference type="OrthoDB" id="761140at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01228">
        <property type="entry name" value="Met_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="PTHR43326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1g" evidence="9">
        <location>
            <begin position="6"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1g" evidence="9">
        <location>
            <begin position="155"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_3" evidence="10">
        <location>
            <begin position="370"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="7">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="7">
        <location>
            <begin position="295"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="509" mass="57924" checksum="8A92664994D457FA" modified="2005-11-22" version="1">MSRTFYVTTPIYYVNDVPHIGHAYTTLAADVLARYKRLKGYDVFFLTGTDEHGQKVEKAANAAGETPLELADRVVKRFQALWEKLDISYNDFIRTTQERHKKGVTHLFREVMAKGDIYLGEYEDWYCTPCETFWTETQLIDGKCPDCNRPVEKLKEESYFFRMSKYQEQLLAHIEANPDFIQPKSRRNEIISFVKEGLRDLSVSRTSFNWGIPVPGNERHVIYVWFDALTNYITALGYPDQAGNYGKFWPVDAHLIGKDILRFHAVYWPTFLMAAGLPVPRKVFAHGWWTVEGQKMSKSLQNVVEPNMLVDKYGIDAVRYFLLREVPFGLDGDFSHAALVHRINSDLANDLGNLLSRSTAMVNKYFGGTLPQPGAMTELDAAFRARTEAMISQLESCMDEMAFSKGLQAIWEVISAGNKYIDESAPWTLAKDPAQKERLGTIMYTLLEAQRIVHTLLSAFMPRTAAKALGYLGCMEALRDEDLAWGKLVPGTQIAKAEALFPRIEDKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TB0</accession>
    <name>Q39TB0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aldehyde:ferredoxin oxidoreductase, tungsten-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2289"/>
    <dbReference type="EnsemblBacteria" id="ABB32514">
        <property type="protein sequence ID" value="ABB32514"/>
        <property type="gene ID" value="Gmet_2289"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2289"/>
    <dbReference type="eggNOG" id="COG2414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_7"/>
    <dbReference type="OMA" id="AYPISHE"/>
    <dbReference type="OrthoDB" id="332680at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="8">
        <location>
            <begin position="9"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="584" mass="62809" checksum="82209B81C0DFBCBC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TB8</accession>
    <name>Q39TB8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Resolvase-like serine recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2281</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366034.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2281"/>
    <dbReference type="EnsemblBacteria" id="ABB32506">
        <property type="protein sequence ID" value="ABB32506"/>
        <property type="gene ID" value="Gmet_2281"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2281"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_0_1_7"/>
    <dbReference type="OMA" id="FTTQIMG"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011109">
        <property type="entry name" value="DNA_bind_recombinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07508">
        <property type="entry name" value="Recombinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="3"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="216" mass="23741" checksum="02213F2FD40D7F89" modified="2005-11-22" version="1">MKRYVSYLRVSTDKQGREGYGVGAQREAVANYLNGGKWELLREFVEVESGRKKDRPELAAALSFCKLTKSTLIVAKLDRLARNVAFVSSLMESGVDFVAVDFPEANKLTVHILAAVAEHEAGMISTRTKAALAAARTRGVKLGNPNLTNEARSAGRVARAMKSDEDAKRVKPIIEGLRLQGMGLRETARELNRQGIRTPLGKDWTATAVKNAMARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TR0</accession>
    <name>Q39TR0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">4-hydroxybenzoyl-CoA reductase iron-sulfur cluster-binding subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcmS</name>
        <name evidence="3" type="ordered locus">Gmet_2135</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513070.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2135"/>
    <dbReference type="EnsemblBacteria" id="ABB32364">
        <property type="protein sequence ID" value="ABB32364"/>
        <property type="gene ID" value="Gmet_2135"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2135"/>
    <dbReference type="eggNOG" id="COG2080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052511_3_1_7"/>
    <dbReference type="OMA" id="QEADDVW"/>
    <dbReference type="OrthoDB" id="1843415at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002888">
        <property type="entry name" value="2Fe-2S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036884">
        <property type="entry name" value="2Fe-2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01799">
        <property type="entry name" value="Fer2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47741">
        <property type="entry name" value="SSF47741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="2">
        <location>
            <begin position="14"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="171" mass="17983" checksum="5CAA3FC10EA67F3F" modified="2005-11-22" version="1">MLQSITDKDGVKRYLITLKVNGDAKTVLVKGNAILTNVLRDHLDLTGTKKGCELGDCGSCTVLLDGKPVDSCLMLAVEADGREITTIEGVAANGALDAIQESMINHAAVQCGYCTPGMVLSAKALLTRNPHPTEPEVREAIAGNLCRCTGYVHIVEAVLAASQGRTAPAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TW2</accession>
    <name>Q39TW2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Benzoyl-CoA reductase electron transfer protein, selenocysteine-containing, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bamF</name>
        <name evidence="4" type="ordered locus">Gmet_2083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32312.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2083"/>
    <dbReference type="KEGG" id="gme:Gmet_2083"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095272_0_0_7"/>
    <dbReference type="OMA" id="PGECHYV"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003813">
        <property type="entry name" value="MvhD/FlpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02662">
        <property type="entry name" value="FlpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0711">Selenium</keyword>
    <keyword evidence="4" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="FlpD" evidence="3">
        <location>
            <begin position="11"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="HTH arsR-type" evidence="2">
        <location>
            <begin position="203"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="4">
        <location>
            <position position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32312.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="255" mass="28632" checksum="556EA09BC941CBD5" modified="2012-10-31" version="2">MSTGRDHKPSVVGFLCTWUAYGAADLAGVSRLQYTTETKIIRVMCTGRVDLAFVLRAFSKGADGVFIGGCWPGECHYVTEGNYDVLKNVHIAKKILERIGINPDRLRLEWIAASEGMRYAEVMNDFGKRLKELGPLGKGEGIEPGALKLRLEAANKLVPYVKLVERERLRQRFKTEQEYTDFFASDELKKLFDELVANKLAVSQITLLLQDKPLNTGEIVTTLGMNASEVSRHLKSATMHGLVRFDEELKRYALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TX0</accession>
    <name>Q39TX0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutaryl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bamM</name>
        <name evidence="9" type="ordered locus">Gmet_2075</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514590.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2075"/>
    <dbReference type="EnsemblBacteria" id="ABB32304">
        <property type="protein sequence ID" value="ABB32304"/>
        <property type="gene ID" value="Gmet_2075"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2075"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_8_0_7"/>
    <dbReference type="OMA" id="AAMDCYD"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="18"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="134"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="238"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="392" mass="43112" checksum="D5ED00D7C1EB038F" modified="2005-11-22" version="1">MSVTTELTDYMGFQGLLTDEEKLVRETARKFVNDEVLPIIEEHALNETFPSHLIPKMGELGFYGPNLPEKYGCAGLSNVAYGLLMYELERGDSGLRSFASVQGSLVMYPIYAYGSEAQKEYWLPKLAAGEKIGCFGLTEPDFGSNPAGMRTNAVREANGKWRINGSKMWITNGSVADVAVVWARTDDGVRGFLVEKGTPGFSAPKMHGKWSLRASVTSELVFEDVIVDEEKSLLPNVKGLKGPLGCLTQARYGIAWGALGAADACYQAALEYALSRIQFDKPIASYQLQQRKLAEMVTEITKGQLLVMQLGRLKDQGNYSPAQVSMAKMNNVHVAINICRTARTILGANGIMSEYPIMRHANNLEAVYTYEGTHDMHLLIIGEKVTGISAFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U12</accession>
    <name>Q39U12_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32262.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2033"/>
    <dbReference type="EnsemblBacteria" id="ABB32262">
        <property type="protein sequence ID" value="ABB32262"/>
        <property type="gene ID" value="Gmet_2033"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2033"/>
    <dbReference type="eggNOG" id="ENOG502ZHVJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2023413_0_0_7"/>
    <dbReference type="OMA" id="NIMSGVQ"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32262.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="125" mass="13845" checksum="8F9E113DFA47DEC2" modified="2012-10-31" version="2">MERETILIIDEAGFSRVCSAILEAEGYRAETIPHESLESRTVCNDGVGLVIASYPYGSCFFEDICRFSLPIIVLTDHISKDLLSALEGFENSICMIKPLDYKKFTSVVRQMMTGTYAGQGGYSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U47</accession>
    <name>Q39U47_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CARDB domain lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1998</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2010-02" db="PDB data bank">
            <title>Solution Structure of GmR58A.</title>
            <authorList>
                <person name="Lee H."/>
                <person name="Montelione G.T."/>
                <person name="Prestegard J.H."/>
            </authorList>
        </citation>
        <scope>STRUCTURE BY NMR OF 470-583</scope>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512952.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="2KUT">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=470-583"/>
    </dbReference>
    <dbReference type="PDBsum" id="2KUT"/>
    <dbReference type="SMR" id="Q39U47"/>
    <dbReference type="STRING" id="269799.Gmet_1998"/>
    <dbReference type="DNASU" id="3739870"/>
    <dbReference type="EnsemblBacteria" id="ABB32227">
        <property type="protein sequence ID" value="ABB32227"/>
        <property type="gene ID" value="Gmet_1998"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1998"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1572">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_383921_0_0_7"/>
    <dbReference type="OrthoDB" id="2087957at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011635">
        <property type="entry name" value="CARDB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07705">
        <property type="entry name" value="CARDB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223293" evidence="1">
        <location>
            <begin position="23"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="CARDB" evidence="2">
        <location>
            <begin position="470"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2KUT"/>
        </source>
    </evidence>
    <sequence length="720" mass="79051" checksum="26B649414AAAAF4E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UH1</accession>
    <name>TIG_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trigger factor</fullName>
            <shortName evidence="1">TF</shortName>
            <ecNumber evidence="1">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">PPIase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tig</name>
        <name type="ordered locus">Gmet_1874</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location>Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">About half TF is bound to the ribosome near the polypeptide exit tunnel while the other half is free in the cytoplasm.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FKBP-type PPIase family. Tig subfamily.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511971.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UH1"/>
    <dbReference type="SMR" id="Q39UH1"/>
    <dbReference type="STRING" id="269799.Gmet_1874"/>
    <dbReference type="EnsemblBacteria" id="ABB32103">
        <property type="protein sequence ID" value="ABB32103"/>
        <property type="gene ID" value="Gmet_1874"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1874"/>
    <dbReference type="eggNOG" id="COG0544">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033058_3_2_7"/>
    <dbReference type="OMA" id="KGIKTQF"/>
    <dbReference type="OrthoDB" id="932993at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00303">
        <property type="entry name" value="Trigger_factor_Tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005215">
        <property type="entry name" value="Trig_fac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008880">
        <property type="entry name" value="Trigger_fac_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037041">
        <property type="entry name" value="Trigger_fac_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008881">
        <property type="entry name" value="Trigger_fac_ribosome-bd_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036611">
        <property type="entry name" value="Trigger_fac_ribosome-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30560">
        <property type="entry name" value="PTHR30560"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05698">
        <property type="entry name" value="Trigger_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05697">
        <property type="entry name" value="Trigger_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003095">
        <property type="entry name" value="Trigger_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102735">
        <property type="entry name" value="SSF102735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00115">
        <property type="entry name" value="tig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0697">Rotamase</keyword>
    <feature type="chain" id="PRO_0000256562" description="Trigger factor">
        <location>
            <begin position="1"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="1">
        <location>
            <begin position="163"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00303"/>
        </source>
    </evidence>
    <sequence length="433" mass="48639" checksum="94547EB2ED7B4F23" modified="2005-11-22" version="1">MTSTVESLSSVKKKISFEIPAERVSAEIEKVFGQIQKRAAIKGFRKGKVPRSLVEQNYRSMMESDVLKNLFDETYFKALADHKIFPVSHPHIESDEVKRGEALKYSATVEVFPEIDVKDYKGLEVKRERFVSDVAPVEARLNEMREGMAELKPLEEGKCAETGNFVVIDFVGSVDGIPFEGGAAESYQLELGSGRFIPGFEDQLVGVKAGEQRTVEVTFPEEYGNKDLAGKAASFAVTVKEAKVKELPELDDEFAMQFGEFETLEQLKTKLAELHKDQETARIKADVQDRIVKALIGNNEIEVPSTLVERQLQMMLSNMKNRLAQQRLSLEMMGMDDESFKTHYRDSAESQVKGSLLLEAVAKKEGITVNDPDVEAKLRAMAEEAGQDFDRVKDFYEQNHNAKENLVAHLNEEKVLGYLLENAVVTEVAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UN2</accession>
    <name>Q39UN2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Menaquinol oxidoreductase complex ACIII, DUF3341 subunit ActD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">actD</name>
        <name evidence="2" type="ordered locus">Gmet_1813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512033.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1813"/>
    <dbReference type="EnsemblBacteria" id="ABB32042">
        <property type="protein sequence ID" value="ABB32042"/>
        <property type="gene ID" value="Gmet_1813"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1813"/>
    <dbReference type="eggNOG" id="ENOG5033HTI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1400736_0_0_7"/>
    <dbReference type="OMA" id="GTAWLYP"/>
    <dbReference type="OrthoDB" id="1875098at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021776">
        <property type="entry name" value="ActD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11821">
        <property type="entry name" value="DUF3341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="194" mass="20758" checksum="BC6D068A2EC29934" modified="2005-11-22" version="1">MEVLGIFSDKESAGVAVEHLIKEGFVERQITSLTSVAYPDGVLVRTEQRTWFRWFTLACGIAGAGAGFLLAAGTAWLYPVKTGDKPIIAFYPTGIVTYELTMLFALAGTIIGMFLEMGLPSLRKRVYDPLIAEGYIGISVSIHSGGVAVACEADVSPRECIGTVAALPSDEQVSRAEELMKAAGAVRIIAEDRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UQ1</accession>
    <name>Q39UQ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512054.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1792"/>
    <dbReference type="EnsemblBacteria" id="ABB32023">
        <property type="protein sequence ID" value="ABB32023"/>
        <property type="gene ID" value="Gmet_1792"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1792"/>
    <dbReference type="eggNOG" id="ENOG5031SP3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_106322_1_0_7"/>
    <dbReference type="OMA" id="DCIKDRL"/>
    <dbReference type="OrthoDB" id="1783313at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="178" mass="20043" checksum="994BEEBA07543AA1" modified="2005-11-22" version="1">MKPLKEMTIGEIAAYVAAHLRQGGVEVVLTGGSCVSIYTDNRYLSYDLDFIEVGRASRKKIAAILMEIGFLEKDRYFIHPDTMYFVEFPSGPLALGAEPAGAIAELEFATGTLRLLSPTDCVKDRLAGYYHWLDRQCLEQAIMVAHDAEIDLEEVERWSQQEGMGEEFERIKTFLLAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UQ8</accession>
    <name>Q39UQ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1785</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513318.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1785"/>
    <dbReference type="EnsemblBacteria" id="ABB32016">
        <property type="protein sequence ID" value="ABB32016"/>
        <property type="gene ID" value="Gmet_1785"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1785"/>
    <dbReference type="HOGENOM" id="CLU_705481_0_0_7"/>
    <dbReference type="OrthoDB" id="867922at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="391" mass="45384" checksum="2E4576731233747D" modified="2005-11-22" version="1">MLKQQSQQHQASPQLPSTEHTTEHHQKQPSGSPVVPGLAGTIGGTEERTATPSPPLPGLESYFPPLPLELDNSSKTLTPELKALFEKWDNEKPRKGACITIFPSGEITGGYYRTGRRTMPHKREKIASEEFTRQARKTIRRAVECGLTSFKLFITLTFDPKLAQLDDEGRVNQDWGKKQFKRFLNTLKKKYDRKLEKQGKDHQELTYIWVAEIQEKTTQNIHFHMLVDQPFIPVQWLVDIWGQANNSVNVKKVSNQEHAAHYMLKYMSKGHCPIEGKRYGMTQNLLEKIKPQRIRLEGEARREAFRRVKRDFYWQIENNGGCISDFGFSIPAPRRERVWRDRQGVMRKTKAIPRSLSEKFLQTLESRVKQIEREKEVDSAYSNDYSDEVPF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39US7</accession>
    <name>LEPA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor 4</fullName>
            <shortName evidence="1">EF-4</shortName>
            <ecNumber evidence="1">3.6.5.n1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Ribosomal back-translocase LepA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lepA</name>
        <name type="ordered locus">Gmet_1766</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.n1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31997.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513337.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39US7"/>
    <dbReference type="SMR" id="Q39US7"/>
    <dbReference type="STRING" id="269799.Gmet_1766"/>
    <dbReference type="EnsemblBacteria" id="ABB31997">
        <property type="protein sequence ID" value="ABB31997"/>
        <property type="gene ID" value="Gmet_1766"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1766"/>
    <dbReference type="eggNOG" id="COG0481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009995_3_3_7"/>
    <dbReference type="OMA" id="MVQIAIQ"/>
    <dbReference type="OrthoDB" id="182107at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="PTHR43512"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000265661" description="Elongation factor 4">
        <location>
            <begin position="1"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="4"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="133"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00071"/>
        </source>
    </evidence>
    <sequence length="599" mass="67272" checksum="3E420B3459A67489" modified="2006-12-12" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UY6</accession>
    <name>Q39UY6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Gmet_1707</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514147.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1707"/>
    <dbReference type="EnsemblBacteria" id="ABB31938">
        <property type="protein sequence ID" value="ABB31938"/>
        <property type="gene ID" value="Gmet_1707"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1707"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003851_1_1_7"/>
    <dbReference type="OMA" id="YSPVWMK"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="557"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="635"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="12">
        <location>
            <begin position="682"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="13">
        <location>
            <begin position="755"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="832"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="1077"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="14">
        <location>
            <begin position="1222"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="791"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="1126"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB31938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1313" mass="145604" checksum="1A030823B98E8A16" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V28</accession>
    <name>Q39V28_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Efflux pump, RND family, membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511398.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1665"/>
    <dbReference type="EnsemblBacteria" id="ABB31896">
        <property type="protein sequence ID" value="ABB31896"/>
        <property type="gene ID" value="Gmet_1665"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1665"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_2_1_7"/>
    <dbReference type="OMA" id="ATINLGY"/>
    <dbReference type="OrthoDB" id="1532186at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="4">
        <location>
            <begin position="69"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="101"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="398" mass="43990" checksum="8AA1E34A04785D9B" modified="2005-11-22" version="1">MFRGMKTTFQPLHCLVLWVLPLLALLQAGCKKPPPPPPPPPKVTVSHPLKREVTDYLELTGNTQAVNSVQLVARVPGYLEKVFFRDGQMVTNGQPLFQLQRNTYEAALRQAEGQVMALKSQLEYAEGQLIRYSNLLPHKAATQTDVDNWRYQRDSARANLKAAEANRDLARLNLGYTLVSAPFSGRIDRRQQDPGNLVGSETNNTVLAQLIQIDPIYVYFTVSDLDLARLLKTNRLPGVAKTEKRPVFIALAQEEGYSHKGYVDFAATSLTPTTGTLLLRGVFRNPSGRILPGLYAKVRLPLERRVALLTPDTAIRSDQQGSYVLTVNGKNTVERRAVKTGHQEDSLRVIEQGLDGSEWVIVKGQLKAPSGSRVTPVREDAEPASAPSRTTAGPKVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VD4</accession>
    <name>Q39VD4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heavy metal transport/detoxification domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511511.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1556"/>
    <dbReference type="EnsemblBacteria" id="ABB31790">
        <property type="protein sequence ID" value="ABB31790"/>
        <property type="gene ID" value="Gmet_1556"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1556"/>
    <dbReference type="eggNOG" id="COG2608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1803422_0_0_7"/>
    <dbReference type="OMA" id="CAFAVRL"/>
    <dbReference type="OrthoDB" id="2061355at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="SSF55008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="1">
        <location>
            <begin position="35"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="142" mass="14559" checksum="CF2FE3C7FE661C77" modified="2005-11-22" version="1">MRKRTVGTGILVACAVGLLVYLAFNVRLAPIPNAVAALKTVGMTCGSCAGKIEKALKPMKGVAGVEVDVKGGWVLVGYDTNSANPETFAGAVRKAGFQSWLMEQMSLADFRRVTGRDFGAKVVRSGGCGTGGCDSGGCGNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VH0</accession>
    <name>Q39VH0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511547.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1520"/>
    <dbReference type="EnsemblBacteria" id="ABB31754">
        <property type="protein sequence ID" value="ABB31754"/>
        <property type="gene ID" value="Gmet_1520"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1520"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1324817_0_0_7"/>
    <dbReference type="OMA" id="HEFAVQF"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023772">
        <property type="entry name" value="DNA-bd_HTH_TetR-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041673">
        <property type="entry name" value="TetR_C_23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17931">
        <property type="entry name" value="TetR_C_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01081">
        <property type="entry name" value="HTH_TETR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="207" mass="22785" checksum="77D0FCCF0F3FE4D6" modified="2005-11-22" version="1">MRISEQAKQENRGRILEKAAKLFCGKGFEATTTRDIALAAGLATGTMFNYFPSKETLAMTMVAEALSRGGDDYEQRRSGNEELAEELFLFIASGLRRLRPLRPFLGPVLERSLSPFPRKTVCPEGEAARQDHLAAVHRIIGRHGFTTAPDYVAITIYWSLYLGVLAFWASDESPNQEASRALIDYSIRMFVQVISGSGPDGGGAHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VH8</accession>
    <name>Q39VH8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glyoxylase-related zinc-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511555.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1512"/>
    <dbReference type="EnsemblBacteria" id="ABB31746">
        <property type="protein sequence ID" value="ABB31746"/>
        <property type="gene ID" value="Gmet_1512"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1512"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056342_4_0_7"/>
    <dbReference type="OMA" id="HMGDLFF"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223319" evidence="1">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="46"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="298" mass="32654" checksum="F9AD54D5825A4052" modified="2005-11-22" version="1">MKRHFLLFPILVLMLATPALADLTKISDNVYSYVGATDASPTHSFAANAGIVIGRDGVLVVDTLLSAKEGERFLADIRKVTTKPIRYVVDTHIHLDHALGNCVFAREGATIISHEAERSSLAQNGAEILRKAGDYGLKPEDMVGTEIVLPSLTFSDRLTIDLGGETVELLRIAPSHTAGSTIVYLPAQKLLFSGDILFTDFHPFFADGDLPNWAKTLDAILAMDVERIVPGHGPLSTKKDLQEMKEYLRLFDAKARDLVATGKDVDTVAAQLAKVLPKRTLAEWMIPANLKARYLHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VL9</accession>
    <name>Q39VL9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511597.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1471"/>
    <dbReference type="EnsemblBacteria" id="ABB31705">
        <property type="protein sequence ID" value="ABB31705"/>
        <property type="gene ID" value="Gmet_1471"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1471"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_868079_0_0_7"/>
    <dbReference type="OMA" id="FIIWRFL"/>
    <dbReference type="OrthoDB" id="1522581at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="322" mass="35429" checksum="4022B417D0E2AC23" modified="2005-11-22" version="1">MNTPSLAFFRNDADERLWKADLEAIPGMISIVTGESPLLSVNKAWGLAPSPQFILLSASFYPDRGVGITTLIRSLFPGTEILLISPASEPFPDIGPLFRDGIVNLVVAPTRLSPKSYCPVESTLSIAVASIAAGRNERMSACLRQGTEVSEFTLTSSSQKETLIGLLEKAVNGKTTEAEFLRQRAALIADEMIENALYGAPRDHQGTRIFRKGELREILPDERIVFRFGFDGENLALEVRDGWGSLRPEDILDHLSKNRARDGIPPTDGGLGLFLIWRFVDHLHVSITPGRETVVRGHVRLARCEDLPEAKGFHITALRDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VN0</accession>
    <name>Q39VN0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport membrane protein, TolR-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511610.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1460"/>
    <dbReference type="EnsemblBacteria" id="ABB31694">
        <property type="protein sequence ID" value="ABB31694"/>
        <property type="gene ID" value="Gmet_1460"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1460"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_1_2_7"/>
    <dbReference type="OMA" id="VAIVTMK"/>
    <dbReference type="OrthoDB" id="1940365at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="135" mass="14529" checksum="1ED267D17D414B7B" modified="2005-11-22" version="1">MKAPADDMDETVEINVVPLLDLAWNLLVVFMIVVTASVQGINVNLPKASAAAGKIKPSTKAITVASEGTIYLDSVPVTLAELETYLRQAKASDPNLPVVVRGDEKVEYKSIVEVLDLLSKLEISQLGLVTQKLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VN8</accession>
    <name>Q39VN8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511617.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1452"/>
    <dbReference type="EnsemblBacteria" id="ABB31686">
        <property type="protein sequence ID" value="ABB31686"/>
        <property type="gene ID" value="Gmet_1452"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1452"/>
    <dbReference type="HOGENOM" id="CLU_1056731_0_0_7"/>
    <dbReference type="OMA" id="TVANGEM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223351" evidence="1">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="245" mass="25455" checksum="777F2FAAB3A01DC6" modified="2005-11-22" version="1">MKKKMIALLAGALMTAAMAGNAMAYFEQDHLVRVVYDKTVMTEVATDLGKVQDIIAAAKNGPVTLGAGADSYLGGALATSALSNLNVAYYAVNVANKDLWLSSKTDTQSIATTQWGTTSSMISNTLGIYAPSATSTVTLAMANPSSYWNKLDGNGTRVGKFNTTYTVANGEMNLAALATGGEAKQNLFFWDNPSLTSGAAGAKQVTIKTLSTGGTQVASNVPVPPALFLMGSGLLGLVGIRRKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VP1</accession>
    <name>Q39VP1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Serine protease, subtilase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511620.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1449"/>
    <dbReference type="EnsemblBacteria" id="ABB31683">
        <property type="protein sequence ID" value="ABB31683"/>
        <property type="gene ID" value="Gmet_1449"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1449"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_1_7_7"/>
    <dbReference type="OMA" id="AYDDFGH"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026442">
        <property type="entry name" value="IPTL_CTERM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04174">
        <property type="entry name" value="IPTL_CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223433" evidence="5">
        <location>
            <begin position="31"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="6">
        <location>
            <begin position="138"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="446" mass="45434" checksum="49649225EF46AE61" modified="2005-11-22" version="1">MPAHRLPVIRKILAATFLAALFSQSPASVAAAAPVEPPGMRQRLSSGAPQEMLILLDEGAIAKSHVIGALRAEGGEVVTDYSHLPMLFARIRSTKALDRLLTAPGIQAVYENRVLRPHLAESLPLIGQPPLAAIGKTGSGTTVAIIDSGINYTLPAFGSCTAPGVPADCKVAASVDIATNDNALDDLGHGTNVAGIVAGVAPGAKLAVLDVFNPDGTSSDALVIAGINWAISNRATYNIVAINMSLGDGSRNTAACSNRGTNPYVTPINNAKSAGIVTVISAGNEGYTDGISRPACTPAAVSVGAVYDANVGGIKWTACTDATSGADKVPCMSNTATFLNMLAPGAFITAAGSTMGGTSQAAPHVAGSVAVLKAQYPNETPDQLISRLISSGKPVTDQRTGGVFPRLDLFSSMGLPDSNFVPAMSPWGIGLSAVFLGGALAVRRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VP5</accession>
    <name>Q39VP5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511624.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1445"/>
    <dbReference type="EnsemblBacteria" id="ABB31679">
        <property type="protein sequence ID" value="ABB31679"/>
        <property type="gene ID" value="Gmet_1445"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1445"/>
    <dbReference type="eggNOG" id="COG5338">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053825_0_0_7"/>
    <dbReference type="OMA" id="EYAFTER"/>
    <dbReference type="OrthoDB" id="2182486at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018759">
        <property type="entry name" value="BBP2_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10082">
        <property type="entry name" value="BBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="410" mass="45391" checksum="BF46323AAC69DCD8" modified="2005-11-22" version="1">MSLPCRRPVSAVQVISAAAALIGTALTMLPVSAFADDFRLLGATALQQEYIDNLFMSPDDRKSSFITTLSGGFEATERTERLDADLTLKLDQIFYTDENRLGNSLNQLYRGGARYRLTELLTLGASAKYELNNRPDQDIERTGLIVEPVTRHRQEYGATANYILSETMSTALSYSYLQDDFNDRTNTQNSSHDLSVVLERNLSAYLPDLTGSLIFGYGNYQTREATDTKVEQYLAMAGISWSYTELWKLFANLGASYTTSEFDTLAGSSLVRNGEHSWGGTGKAGVSYRDEYTAGTLAFSQGIVPASGRSGASRRTGLTLDLSRRFTEELTGFLSSGFFLNRSDRGEFSAGEIDETTFNAGIGARYNVSRDFSLEARYGYARIDYGVSGQTAERNGVMMSLVYRYPFLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VR4</accession>
    <name>Q39VR4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bifunctional uridylyltransferase/uridylyl-removing enzyme</fullName>
            <shortName evidence="7">UTase/UR</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Bifunctional [protein-PII] modification enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Bifunctional nitrogen sensor protein</fullName>
        </alternativeName>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII] uridylyltransferase</fullName>
                <shortName evidence="7">PII uridylyltransferase</shortName>
                <shortName evidence="7">UTase</shortName>
                <ecNumber evidence="7">2.7.7.59</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">[Protein-PII]-UMP uridylyl-removing enzyme</fullName>
                <shortName evidence="7">UR</shortName>
                <ecNumber evidence="7">3.1.4.-</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="7 11" type="primary">glnD</name>
        <name evidence="11" type="ordered locus">Gmet_1426</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-L-tyrosine + UTP = [protein-PII]-uridylyl-L-tyrosine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13673"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
            <dbReference type="EC" id="2.7.7.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>[protein-PII]-uridylyl-L-tyrosine + H2O = [protein-PII]-L-tyrosine + H(+) + UMP</text>
            <dbReference type="Rhea" id="RHEA:48600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12147"/>
            <dbReference type="Rhea" id="RHEA-COMP:12148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:90602"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="7">Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the GlnD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.59" evidence="7"/>
    <dbReference type="EC" id="3.1.4.-" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511642.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1426"/>
    <dbReference type="EnsemblBacteria" id="ABB31660">
        <property type="protein sequence ID" value="ABB31660"/>
        <property type="gene ID" value="Gmet_1426"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1426"/>
    <dbReference type="eggNOG" id="COG2844">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012833_1_0_7"/>
    <dbReference type="OMA" id="WIAKYVY"/>
    <dbReference type="OrthoDB" id="162558at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008773">
        <property type="term" value="F:[protein-PII] uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00277">
        <property type="entry name" value="PII_uridylyl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005105">
        <property type="entry name" value="GlnD_Uridyltrans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013546">
        <property type="entry name" value="PII_UdlTrfase/GS_AdlTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010043">
        <property type="entry name" value="UTase/UR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47320">
        <property type="entry name" value="PTHR47320"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03445">
        <property type="entry name" value="DUF294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08335">
        <property type="entry name" value="GlnD_UR_UTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006288">
        <property type="entry name" value="PII_uridyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01693">
        <property type="entry name" value="UTase_glnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51831">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2 7 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HD" evidence="10">
        <location>
            <begin position="476"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="716"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="829"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Uridylyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="899" mass="102917" checksum="A0F924CABDC75140" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VS2</accession>
    <name>Q39VS2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcriptional regulator, MerR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511649.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1418"/>
    <dbReference type="EnsemblBacteria" id="ABB31652">
        <property type="protein sequence ID" value="ABB31652"/>
        <property type="gene ID" value="Gmet_1418"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1418"/>
    <dbReference type="eggNOG" id="COG0789">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045945_4_2_7"/>
    <dbReference type="OMA" id="AKGNRMF"/>
    <dbReference type="OrthoDB" id="1661714at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000551">
        <property type="entry name" value="MerR-type_HTH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13411">
        <property type="entry name" value="MerR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00422">
        <property type="entry name" value="HTH_MERR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50937">
        <property type="entry name" value="HTH_MERR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH merR-type" evidence="1">
        <location>
            <begin position="10"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="116" mass="13548" checksum="174B5EC77638C7B5" modified="2005-11-22" version="1">MEAKLPDKQYFRIGEVARLTALKTSVLRFWETEFKDLSPPKSRTGQRLYSRQDIGLLLEIKRLLYVEKLTIEGARKKLKTTSRSGETILTESNDVHRLLSLVKEVRDELETIRLML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VT0</accession>
    <name>Q39VT0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose--lipopolysaccharide heptosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511657.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1410"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="DNASU" id="3738936"/>
    <dbReference type="EnsemblBacteria" id="ABB31644">
        <property type="protein sequence ID" value="ABB31644"/>
        <property type="gene ID" value="Gmet_1410"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1410"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_3_0_7"/>
    <dbReference type="OMA" id="QYYCISE"/>
    <dbReference type="OrthoDB" id="1068323at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="367" mass="40028" checksum="6CD604BA6F90F6E5" modified="2005-11-22" version="1">MNLRLIKAADAILGRVATVLLPAPVVGCYGTSIRSVLFIRPGGIGDAVLLIPAILSFRNKYPKARITVLAEKRNGAVFTLCSVIDEILLYDNNGELFMALRGSYDAVIDTEQWHRLSAVVARMTWAQILIGFGTNVRSRLFTHQLDYEQSDYEETSFLRLLTSLGIAVTQTSVPFLTVPTPAASVAEVLLGELADRTFVVIFPGASIPERRWGADKFRQVAKRLSAKGVSGVVVGGEDDRGEGERIVADTGWLNLMGETSLQETTAIIERSSLLVSGDSGILHIAVGLGIPTVSLFGPGREKKWAPRGDNHIVINKHLPCSPCTTFGYTPKCPINARCMAEISVDEVEQAVLTLLDRKNFDKHQQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W64</accession>
    <name>Q39W64_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31510.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365796.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1274"/>
    <dbReference type="DNASU" id="3739773"/>
    <dbReference type="EnsemblBacteria" id="ABB31510">
        <property type="protein sequence ID" value="ABB31510"/>
        <property type="gene ID" value="Gmet_1274"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1274"/>
    <dbReference type="eggNOG" id="COG0775">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031248_4_1_7"/>
    <dbReference type="OMA" id="KPWIIPQ"/>
    <dbReference type="OrthoDB" id="1860206at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="SSF53167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNP_UDP_1" evidence="1">
        <location>
            <begin position="3"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31510.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="252" mass="26845" checksum="1351EC4057693AF4" modified="2012-10-31" version="2">MGTIGLIAAMPDEIRPFLRLASPAARLHGGRFPIWRLRVGNDDIVLVESGMGIDRATAATDALVAAASPVAILSFGFGGAALPGLKVGDLAVGMTSWFAGTEGIVLRRGIDRNLAEKLAEELNRICNGVTRGEIITSARILKKGDLAHSLPNGISSPILDMETAAVAEAAHRRGIPIVALRAISDDAEEELSFSLDEFTDDDMAIRPRKVLATIARKPWIIPQLLRLARNSRIAGKRLAQGVLATAEFLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W73</accession>
    <name>Q39W73_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="5 9">2.3.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Alpha-IPM synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Alpha-isopropylmalate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">leuA</name>
        <name evidence="11" type="ordered locus">Gmet_1265</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="5 9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512102.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1265"/>
    <dbReference type="EnsemblBacteria" id="ABB31501">
        <property type="protein sequence ID" value="ABB31501"/>
        <property type="gene ID" value="Gmet_1265"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1265"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_0_1_7"/>
    <dbReference type="OMA" id="NTMRMLV"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00070"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01025">
        <property type="entry name" value="LeuA_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005671">
        <property type="entry name" value="LeuA_bact_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00973">
        <property type="entry name" value="leuA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="512" mass="55904" checksum="D6C325B1C0D1CBE4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WB5</accession>
    <name>Q39WB5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">rRNA methyltransferase, YqxC-related, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TlyA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512147.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1222"/>
    <dbReference type="EnsemblBacteria" id="ABB31459">
        <property type="protein sequence ID" value="ABB31459"/>
        <property type="gene ID" value="Gmet_1222"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1222"/>
    <dbReference type="eggNOG" id="COG1189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058015_3_0_7"/>
    <dbReference type="OMA" id="VLMVKPQ"/>
    <dbReference type="OrthoDB" id="1670446at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004538">
        <property type="entry name" value="Haemolysin_A/TlyA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32319:SF0">
        <property type="entry name" value="PTHR32319:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005578">
        <property type="entry name" value="TlyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00478">
        <property type="entry name" value="tly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S4" evidence="4">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="28129" checksum="557FABC2B4E1247D" modified="2005-11-22" version="1">MTSPASPSGIRNRERLDKLLVDRGLVQSRERARALIMAGQVVVNDHLADKAGTQVPLDADIRLKGEDIPFVSRGGLKLARALDEFGLDVTDMVAIDVGASTGGFTDCLLQRGARKVYAVDVGYGQLAWKLRQDPRVVNLEKTNIRYLEPDALPEVPDLAVIDASFISLDKVLPPTLRLIRDGGAVVALIKPQFEVGKGEVGKGGVVRDEGKHREVVDNVVALAESLDLQVGGITESPILGPKGNREFLIHLIKRHISPNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WH6</accession>
    <name>Q39WH6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methylenetetrahydrofolate reductase</fullName>
            <ecNumber evidence="8">1.5.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">metF-1</name>
        <name evidence="9" type="ordered locus">Gmet_1160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:19821"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19817"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the methylenetetrahydrofolate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.20" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31398.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1160"/>
    <dbReference type="EnsemblBacteria" id="ABB31398">
        <property type="protein sequence ID" value="ABB31398"/>
        <property type="gene ID" value="Gmet_1160"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1160"/>
    <dbReference type="eggNOG" id="COG0685">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057297_2_0_7"/>
    <dbReference type="OMA" id="QGVHLMA"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106312">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106313">
        <property type="term" value="F:methylenetetrahydrofolate reductase NADPH activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00537">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003171">
        <property type="entry name" value="Mehydrof_redctse-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02219">
        <property type="entry name" value="MTHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="SSF51730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0274">FAD</keyword>
    <keyword evidence="5 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31398.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="293" mass="31070" checksum="015DF3B096A72EED" modified="2012-10-31" version="2">MSSTLREKLESNRFVITAEVCPPKGCDCGEFMEKARNLKGLVDAINVTDNQGANVRISPLAPAALLTREGIEPILQLTCRDRNRMALQSELLAAAALGVTNILSLSGDYISFGDHAGAKPVFDLDSVQLLQTIAALNAGRDFSGAPLEGAPSFFAGAAAAPEADPFDLTLPKLAKKVSAGARFFQTQAVFSPDRLARFSEAVRPLGVKIIAGIILLKSAGMARYITKNIPGLKVPPEIVAELEAAGRPLEVGVAIARRLATAARPFCDGVHIMAMGREELVPNIVAGLRNEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WI1</accession>
    <name>Q39WI1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, TerC family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TerC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513420.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1155"/>
    <dbReference type="EnsemblBacteria" id="ABB31393">
        <property type="protein sequence ID" value="ABB31393"/>
        <property type="gene ID" value="Gmet_1155"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1155"/>
    <dbReference type="eggNOG" id="COG0861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045644_1_2_7"/>
    <dbReference type="OMA" id="ADHAREY"/>
    <dbReference type="OrthoDB" id="1917125at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005496">
        <property type="entry name" value="Integral_membrane_TerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022369">
        <property type="entry name" value="Integral_membrane_TerC_rswitch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30238:SF0">
        <property type="entry name" value="PTHR30238:SF0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03741">
        <property type="entry name" value="TerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03718">
        <property type="entry name" value="R_switched_Alx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="311" mass="35350" checksum="FA5645376D5F677B" modified="2005-11-22" version="1">MSLQTMMWLGFGAIILVMFVIDLGVFSRKSHEIRFREALTWTIVWVSLALAFNVWIYFEMGSTKALEFFTGYLIEQSLSVDNLFVFIMIFSYFHITKVHQPKILKWGIIGALIMRAIFIMTGIELIERFHWIIYLFGGILVVTGFKMAFGGDEKIDPEKNFLIRLVRKFVPVTKRVRDDRFFINKGGIRAATPLFLTLVMIESSDLIFAVDSIPAVLAVSHDPFIVYTSNVFAIMGLRSLYYLLSNVMEMFVYLKLGVSIILVYVGAKMLLVDVYQIPIIFSLGTIVGVLAISILISVTIGNRRAKAAHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WJ2</accession>
    <name>Q39WJ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513408.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1144"/>
    <dbReference type="EnsemblBacteria" id="ABB31382">
        <property type="protein sequence ID" value="ABB31382"/>
        <property type="gene ID" value="Gmet_1144"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1144"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_296094_0_0_7"/>
    <dbReference type="OrthoDB" id="856678at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045392">
        <property type="entry name" value="DUF6519"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20129">
        <property type="entry name" value="DUF6519"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1020" mass="107525" checksum="D043A608E32B293B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WJ5</accession>
    <name>Q39WJ5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Baseplate_J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513405.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1141"/>
    <dbReference type="EnsemblBacteria" id="ABB31379">
        <property type="protein sequence ID" value="ABB31379"/>
        <property type="gene ID" value="Gmet_1141"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1141"/>
    <dbReference type="eggNOG" id="COG3299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_280579_0_0_7"/>
    <dbReference type="OMA" id="LVEMIDY"/>
    <dbReference type="OrthoDB" id="109272at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006949">
        <property type="entry name" value="Baseplate_J-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04865">
        <property type="entry name" value="Baseplate_J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Baseplate_J" evidence="1">
        <location>
            <begin position="709"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1088" mass="117845" checksum="BD414D7B9CBBA54E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WP5</accession>
    <name>NHAA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Na(+)/H(+) antiporter NhaA</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Sodium/proton antiporter NhaA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nhaA</name>
        <name type="ordered locus">Gmet_1089</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+)(out) + Na(+)(in) = 2 H(+)(in) + Na(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:29252"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365771.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39WP5"/>
    <dbReference type="SMR" id="Q39WP5"/>
    <dbReference type="STRING" id="269799.Gmet_1089"/>
    <dbReference type="TCDB" id="2.A.33.1.3">
        <property type="family name" value="the nhaa na(+):h(+) antiporter (nhaa) family"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31329">
        <property type="protein sequence ID" value="ABB31329"/>
        <property type="gene ID" value="Gmet_1089"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1089"/>
    <dbReference type="eggNOG" id="COG3004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015803_1_2_7"/>
    <dbReference type="OMA" id="WHTPFGF"/>
    <dbReference type="OrthoDB" id="1805428at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015081">
        <property type="term" value="F:sodium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006885">
        <property type="term" value="P:regulation of pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01844">
        <property type="entry name" value="NhaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023171">
        <property type="entry name" value="Na/H_antiporter_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004670">
        <property type="entry name" value="NhaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30341">
        <property type="entry name" value="PTHR30341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06965">
        <property type="entry name" value="Na_H_antiport_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0915">Sodium</keyword>
    <keyword id="KW-0739">Sodium transport</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000334305" description="Na(+)/H(+) antiporter NhaA">
        <location>
            <begin position="1"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01844"/>
        </source>
    </evidence>
    <sequence length="382" mass="40374" checksum="488A3FCB948E1E75" modified="2005-11-22" version="1">MRKPINLLREFSVPLIAGVITALAWANLDPRGYDALIHQPSFGGVSLHFLVNELFMVLFFGIAAAEITQSCLPGGDLNPPRKAVNPLLATLGGVIGPVLVYLSLNAVIGDPTLTKGWGIPTATDIALAWLVARLVFGAGHPAVSFLLLLAVADDAIGLAIIAVFYPDPVHPTEPMWLFLTVAGIVAAYILRGARAKSYWPYVLVGGGLSWTGLFKAHLHPALALVFIIPFLPHPPRESAHLFEENPRDTSPLARFEHDWKIVVDFGLFLFGLANAGVRFSSVGTATWLVLTALLVGKTAGILTMGSLGKALGFPLPDRVGFKELALTGLVAGMGLTVALFVAGVAFVDPDIEGAAKMGALLSGGVLPVAVALGRILKVRRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WR7</accession>
    <name>Q39WR7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Csd2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csd2</name>
        <name evidence="1" type="ordered locus">Gmet_1067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513243.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1067"/>
    <dbReference type="EnsemblBacteria" id="ABB31307">
        <property type="protein sequence ID" value="ABB31307"/>
        <property type="gene ID" value="Gmet_1067"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1067"/>
    <dbReference type="eggNOG" id="COG3649">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071770_2_0_7"/>
    <dbReference type="OMA" id="YDFVLLF"/>
    <dbReference type="OrthoDB" id="598606at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006482">
        <property type="entry name" value="Cas7_Csh2/Csh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013418">
        <property type="entry name" value="CRISPR-assoc_prot_Csd2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05107">
        <property type="entry name" value="Cas_Cas7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02589">
        <property type="entry name" value="cas_Csd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01595">
        <property type="entry name" value="cas_CT1132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="284" mass="31822" checksum="1C3F3A1739C819E5" modified="2005-11-22" version="1">MTIQNRYDFVLFFDVKDGNPNGDPDAGNLPRIDPETGHGLVTDVCLKRKVRNYVQLDKELSQGYDIFVKEKAILNNLIDEAHEQENVKAKEKGEKTEAARQFMCGKYFDVRTFGAVMSTGKNAGQVRGPVQLTFARSVDQIVPLEHSITRMAVATPAEAEKQDGDNRTMGRKFTVPYALYRCHGFISAPLAAQTGFSEEDLELFWQSLVNMFEHDRSAARGQMSARKLIVFKHDSKMGNAPAHHLFDLVSAEASETPVRSFDQYDICVPTQENMPTGVTVVEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WU6</accession>
    <name>Q39WU6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">moeA-1</name>
        <name evidence="9" type="ordered locus">Gmet_1038</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513211.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1038"/>
    <dbReference type="EnsemblBacteria" id="ABB31278">
        <property type="protein sequence ID" value="ABB31278"/>
        <property type="gene ID" value="Gmet_1038"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1038"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_0_7"/>
    <dbReference type="OMA" id="GKPLMHG"/>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="175"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="405" mass="43047" checksum="9311366783576C2F" modified="2005-11-22" version="1">MPSFTEARNIILDRVTPLGIERVGILEAAGRVLAEDVVAPWEMPLCDNSAMDGFAVRAADCATIPAALKVTGYIPAGGEVTGAVESGCAIRIMTGAPLPPGCDAVVPVEETEDDGAAIRVVAPVKERQHIRFKGEDVATGETVIPAGTLIQPPEVSMLASFGKALVPVFRKARVAILSTGDELVELGEPPVPGKIINSNTLSLAAAVRQCGAEPIVIGIARDNRESHREKLAEGLKADALITSAGVSAGDRDLVRDVLAEMGVEQIFWKVDMKPGGPTAFGMHGAKPVFSLPGNPVSTMVTFELFARPALLRMMGHRRVVRPFVKAILREDAKKKPGKVNFLRVQVTVQEGRFVASTAGDQHTGILRTMVRANGLALLPLEASIVHAGSEVDLMLLRDDVTMLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WX3</accession>
    <name>Q39WX3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphatidylethanolamine-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1009</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513179.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1009"/>
    <dbReference type="EnsemblBacteria" id="ABB31251">
        <property type="protein sequence ID" value="ABB31251"/>
        <property type="gene ID" value="Gmet_1009"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1009"/>
    <dbReference type="eggNOG" id="COG1881">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083918_3_2_7"/>
    <dbReference type="OMA" id="LAWDEVP"/>
    <dbReference type="OrthoDB" id="1150223at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00865">
        <property type="entry name" value="PEBP_bact_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005247">
        <property type="entry name" value="YbhB_YbcL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="PTHR30289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="SSF49777"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00481">
        <property type="entry name" value="TIGR00481"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223393" evidence="1">
        <location>
            <begin position="23"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="176" mass="19370" checksum="91EA55B6DA413F88" modified="2005-11-22" version="1">MGKRIMPWLLAGLFMAPPAAIGKEARTMSELQISSPAFTHKGAIPARFTCDGQDINPSLAFGNIPAGTKSLALIVDDPDAPVGMWVHWVMWNIPPETREIRENSVPADAIQGLNDWKKNRYGGPCPPSGTHRYFFKLYALDSKLTLAPATTKTALERAMTGHILARGELMGTYRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X11</accession>
    <name>Q39X11_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus biogenesis ATPase PilM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilM</name>
        <name evidence="2" type="ordered locus">Gmet_0971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365752.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0971"/>
    <dbReference type="EnsemblBacteria" id="ABB31213">
        <property type="protein sequence ID" value="ABB31213"/>
        <property type="gene ID" value="Gmet_0971"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0971"/>
    <dbReference type="eggNOG" id="COG4972">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050686_0_2_7"/>
    <dbReference type="OMA" id="EKVQDRQ"/>
    <dbReference type="OrthoDB" id="1750212at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005883">
        <property type="entry name" value="PilM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003494">
        <property type="entry name" value="SHS2_FtsA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11104">
        <property type="entry name" value="PilM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019169">
        <property type="entry name" value="PilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00842">
        <property type="entry name" value="FtsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01175">
        <property type="entry name" value="pilM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FtsA" evidence="1">
        <location>
            <begin position="9"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="351" mass="38795" checksum="D92FA0B2B6005F39" modified="2005-11-22" version="1">MFFSKKKDLVGIDIGSSSVKLVQLREQKGAWQLLNVGTMPLPSEAIVDNTLMDSSAIVDAVKNLGKSLSVKVKEAACSISGNTVIIRKIKLPAMPPEELEDQIRWEAEQYIPFDINDVNIDFQILEPDEDDPTRMNVLLVASKKEIINDYVNVFAESGFKLVIVDVDSFAVQNAFELNYESGPEEVVALINIGASILNLNIVRGGISLFTRDVQMGGNLFTEEIQKQFALSSDEAERVKLTGDHPDQEKLRSVLARINETLSIEVRRSLDFYNTTAGEGRVSKVYLSGGAAKTAMLADAIQDKLGVPVEMLNPFRKITCSEKEFDPEYLREIGPLVTVALGLAARRVGDKW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X31</accession>
    <name>SECA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein translocase subunit SecA</fullName>
            <ecNumber evidence="1">7.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">secA</name>
        <name type="ordered locus">Gmet_0951</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + cellular proteinSide 1 = ADP + phosphate + cellular proteinSide 2.</text>
            <dbReference type="EC" id="7.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">May bind 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF-YajC and YidC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="1">Distribution is 50-50.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SecA family.</text>
    </comment>
    <dbReference type="EC" id="7.4.2.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514434.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X31"/>
    <dbReference type="SMR" id="Q39X31"/>
    <dbReference type="STRING" id="269799.Gmet_0951"/>
    <dbReference type="EnsemblBacteria" id="ABB31193">
        <property type="protein sequence ID" value="ABB31193"/>
        <property type="gene ID" value="Gmet_0951"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0951"/>
    <dbReference type="eggNOG" id="COG0653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005314_3_0_7"/>
    <dbReference type="OMA" id="MVHYDVQ"/>
    <dbReference type="OrthoDB" id="212453at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008564">
        <property type="term" value="F:protein-exporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd18803">
        <property type="entry name" value="SF2_C_secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01382">
        <property type="entry name" value="SecA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004027">
        <property type="entry name" value="SEC_C_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000185">
        <property type="entry name" value="SecA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011115">
        <property type="entry name" value="SecA_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014018">
        <property type="entry name" value="SecA_motor_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011130">
        <property type="entry name" value="SecA_preprotein_X-link_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044722">
        <property type="entry name" value="SecA_SF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011116">
        <property type="entry name" value="SecA_Wing/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036266">
        <property type="entry name" value="SecA_Wing/Scaffold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036670">
        <property type="entry name" value="SecA_X-link_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30612">
        <property type="entry name" value="PTHR30612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02810">
        <property type="entry name" value="SEC-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07517">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01043">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07516">
        <property type="entry name" value="SecA_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00906">
        <property type="entry name" value="SECA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00957">
        <property type="entry name" value="SecA_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00958">
        <property type="entry name" value="SecA_PP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81767">
        <property type="entry name" value="SSF81767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81886">
        <property type="entry name" value="SSF81886"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00963">
        <property type="entry name" value="secA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51196">
        <property type="entry name" value="SECA_MOTOR_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0811">Translocation</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000318359" description="Protein translocase subunit SecA">
        <location>
            <begin position="1"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="846"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="105"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="512"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="885"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="887"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="896"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="897"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="899" mass="102343" checksum="E29AACD8B0C2A198" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X74</accession>
    <name>Q39X74_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365742.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0908"/>
    <dbReference type="EnsemblBacteria" id="ABB31150">
        <property type="protein sequence ID" value="ABB31150"/>
        <property type="gene ID" value="Gmet_0908"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0908"/>
    <dbReference type="eggNOG" id="ENOG50321RF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_682884_0_0_7"/>
    <dbReference type="OMA" id="AQKYWLG"/>
    <dbReference type="OrthoDB" id="674207at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223387" evidence="1">
        <location>
            <begin position="24"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="405" mass="45379" checksum="92AE76AC6B5E791C" modified="2005-11-22" version="1">MGIKWFTHILLLAGVVSASTGFAAQINGRSSTQLIWFNDYYSGRQVELVEYLRLSVTKIDEAGKFSLYGYGRGSQDLNNGDGLNGRLYYLYADYRGLFDKVDFRLGRQFVNNSAGTALVDGGQIDLRNIGPIGFNVFGGRDVVFGINGEAGHSGNYAMGLSAYLSGFRNTDLDVSWFRKWDDGDVSRDILGASFKQYLFNRLKLYGNARYDVTAEVFNEVLGGVKYFPMANLIFTGEWYQSYPTFDTTSIYSVFAVNRYQEGVFRVDYTINDMIAVNAGYSRQDYGDDGIANVYELGCRLHPISSVEIGLAYDKRNGYGGKLDGGQLDVAWDVTKGLQLSGGLTYDVYQRDFYLDGSSRETAQKYWLGGKYKLARNLQASLRVEDAITARDESDINGRFVLDYDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XB6</accession>
    <name>ISPH_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxy-3-methylbut-2-enyl diphosphate reductase</fullName>
            <shortName evidence="1">HMBPP reductase</shortName>
            <ecNumber evidence="1">1.17.7.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispH</name>
        <name type="ordered locus">Gmet_0866</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24488"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dimethylallyl diphosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:24825"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from (2E)-4-hydroxy-3-methylbutenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspH family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513012.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XB6"/>
    <dbReference type="SMR" id="Q39XB6"/>
    <dbReference type="STRING" id="269799.Gmet_0866"/>
    <dbReference type="EnsemblBacteria" id="ABB31108">
        <property type="protein sequence ID" value="ABB31108"/>
        <property type="gene ID" value="Gmet_0866"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0866"/>
    <dbReference type="eggNOG" id="COG0761">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027486_0_1_7"/>
    <dbReference type="OMA" id="HNKYVVD"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00097"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00105"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051745">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13944">
        <property type="entry name" value="lytB_ispH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00191">
        <property type="entry name" value="IspH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003451">
        <property type="entry name" value="LytB/IspH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30426">
        <property type="entry name" value="PTHR30426"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02401">
        <property type="entry name" value="LYTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00216">
        <property type="entry name" value="ispH_lytB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000021126" description="4-hydroxy-3-methylbut-2-enyl diphosphate reductase">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="216"/>
            <end position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00191"/>
        </source>
    </evidence>
    <sequence length="282" mass="30730" checksum="09DB2BA273541317" modified="2005-11-22" version="1">MEIILAKRAGFCFGVKRATQMAFEAAEKEGKTYSLGPIIHSPQVVHRLEEMGVKVLKGLGEITDGTIIVRSHGVTSEELEEAVRKELEVVDATCPFVKKAQENVQNLSEAGYEVVVVGDADHPEVQGIVSYAKGKVCVVGSEEEAARLPKMKKIGIVAQTTQSFDNLKHVVLECLRKGAEIRIFNTICDATAVRQQEATALARTVDCMIVIGGYNSANTKRLAEVCAELQPRTHQIETAQEINPAWFEGVAKVGVTAGASTPKWLIDEVIERIREIDSAKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XD7</accession>
    <name>Q39XD7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SAM-dependent methyltransferase, PUA domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0845"/>
    <dbReference type="EnsemblBacteria" id="ABB31087">
        <property type="protein sequence ID" value="ABB31087"/>
        <property type="gene ID" value="Gmet_0845"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0845"/>
    <dbReference type="eggNOG" id="COG1092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014042_0_0_7"/>
    <dbReference type="OMA" id="VMDVFDY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041532">
        <property type="entry name" value="RlmI_PUA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019614">
        <property type="entry name" value="SAM-dep_methyl-trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10672">
        <property type="entry name" value="Methyltrans_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17785">
        <property type="entry name" value="PUA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="397" mass="43935" checksum="4850421D7F8DDDD2" modified="2005-11-22" version="1">MTMETTTIRVTLNRGEDRRIKGGHPWVFSNEIREAKGERIPGATAEVYDVGGGFLGTGYYNPHSLIAVRLLSREREEIDSPAFFKERINQALKLRRSLYPDMATFRVVHGEGDFLPGLVVDKYGDRLSVQILTAGIEARRGAIVEALVELFAPKGIIARNDVAVRSLEGLAETVEILYREIPETVEAEEHGLRFRVDLAGGQKTGHFLDQKENHLVLKGMAAGKRVLDCFSYSGSWGVHAAAFGAAEVTCLDISERAAALARENAALNGLEGVVSVEVCDAFDRLRSLRHEGRRFDVVVLDPPAFVKNKKALKEAEKGYLTINRRGLELLDAGGYLITCSCSYHMGRELFRDLLAQAARQAGRQVRIVETRSQAPDHPALLAVPETEYLKCFVLQCV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XE0</accession>
    <name>BIOF_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">8-amino-7-oxononanoate synthase</fullName>
            <shortName evidence="1">AONS</shortName>
            <ecNumber evidence="1">2.3.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-keto-8-amino-pelargonic acid synthase</fullName>
            <shortName evidence="1">7-KAP synthase</shortName>
            <shortName evidence="1">KAPA synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">8-amino-7-ketopelargonate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bioF</name>
        <name type="ordered locus">Gmet_0842</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylative condensation of pimeloyl-[acyl-carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>6-carboxyhexanoyl-[ACP] + H(+) + L-alanine = (8S)-8-amino-7-oxononanoate + CO2 + holo-[ACP]</text>
            <dbReference type="Rhea" id="RHEA:42288"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9955"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78846"/>
            <dbReference type="ChEBI" id="CHEBI:149468"/>
            <dbReference type="EC" id="2.3.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; biotin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.47" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31084.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365730.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XE0"/>
    <dbReference type="SMR" id="Q39XE0"/>
    <dbReference type="STRING" id="269799.Gmet_0842"/>
    <dbReference type="EnsemblBacteria" id="ABB31084">
        <property type="protein sequence ID" value="ABB31084"/>
        <property type="gene ID" value="Gmet_0842"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0842"/>
    <dbReference type="eggNOG" id="COG0156">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015846_11_0_7"/>
    <dbReference type="OMA" id="YPYFRPI"/>
    <dbReference type="OrthoDB" id="479874at2"/>
    <dbReference type="UniPathway" id="UPA00078"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008710">
        <property type="term" value="F:8-amino-7-oxononanoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01693">
        <property type="entry name" value="BioF_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004723">
        <property type="entry name" value="AONS_Archaea/Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022834">
        <property type="entry name" value="AONS_Proteobacteria"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00858">
        <property type="entry name" value="bioF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0093">Biotin biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000380996" description="8-amino-7-oxononanoate synthase">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="106"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01693"/>
        </source>
    </evidence>
    <sequence length="391" mass="41238" checksum="B2F3D6B8B25EA760" modified="2013-07-24" version="2">MSKSFAEELEMLKAQGLHRRMRRIAGSQGSRAVVDGKEALLLCSNNYLGLADHPRLAEAAIRAVERYGTSSGASRLVSGTMELHALLEERIARFKGTGAALVFNSGYAANSGIIPALVGKGDVVFSDRLNHASIVDGCLLSRATMVRYPHNDTAALRRLMERHETAGRRLLVTDGVFSMDGDMAPLRELAALKREFGALLMVDDAHGTGVLGATGRGSAELQGVMAEIDIHMGTLGKALGSFGAYAAASEDVIDYLANKARSFIFSTSLPPAVLAASLAAVDLVDSPDGAALRERLARNTAFFREGLCAAGFDTMGSETQIVPLFVGGAEETMAFTARLLEAGVFAQGIRPPTVPAGTCRLRCTLMATHAEEDLARAVALMAAIGKGMGVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XI7</accession>
    <name>Q39XI7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513540.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0795"/>
    <dbReference type="EnsemblBacteria" id="ABB31037">
        <property type="protein sequence ID" value="ABB31037"/>
        <property type="gene ID" value="Gmet_0795"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0795"/>
    <dbReference type="eggNOG" id="COG0500">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049344_5_1_7"/>
    <dbReference type="OMA" id="WDCATGN"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="42"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="250" mass="28045" checksum="95FDAB41932F4EE3" modified="2005-11-22" version="1">MAQQFKDYFSEKSDVYRSYRPGYPTELFAWLAGLPARRDAALDCGCGTGQASVALAEHFARVYAVDPSAGQIKSATPHKRVEYRVAPAEETGLPDASVDLVIAAQALHWFDFSRFYAEVRRVARGGAVFAAFTYGLLAIDDEIDRIIGRFYRDVIGPYWPPERAHVDAGYRTLPFPFAEIETPTFAMKAEWDLGHLMGYFETWSAVKEYRRLRGDDPLELVAGDLATAWGDPALVRQVSWPLVLRAGRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XP9</accession>
    <name>Q39XP9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30975.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0733"/>
    <dbReference type="EnsemblBacteria" id="ABB30975">
        <property type="protein sequence ID" value="ABB30975"/>
        <property type="gene ID" value="Gmet_0733"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0733"/>
    <dbReference type="HOGENOM" id="CLU_1233578_0_0_7"/>
    <dbReference type="OMA" id="IEPMAST"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30975.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="224" mass="24375" checksum="D3094B012D881D2D" modified="2012-10-31" version="2">MLGSVPFVGSVHAMSAFSRKYGMKCDSCHRQRIPELNDFGVAFYKNGFMLPGQNGSAKKDTAASAAVPPVTGKESDSAGEGAPKASVKGPGEGKNEEEEEEEEEEPPPPPTVVYRLPSRDGSVYFTDNPIRQESVPVLRKKQGSRPAPSRAGVIHPAKHQGRVAAKQRMLSSVSAAVSQEHFRSYEECMEQSLLKEPPPISAEETMNRLTAAEKRCSAYQSIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XS8</accession>
    <name>Q39XS8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514096.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0704"/>
    <dbReference type="EnsemblBacteria" id="ABB30946">
        <property type="protein sequence ID" value="ABB30946"/>
        <property type="gene ID" value="Gmet_0704"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0704"/>
    <dbReference type="HOGENOM" id="CLU_2537760_0_0_7"/>
    <dbReference type="OMA" id="DLERHTW"/>
    <dbReference type="OrthoDB" id="2011465at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="83" mass="9172" checksum="5F70158E9AF45114" modified="2005-11-22" version="1">MSERELELLARIEQLERHTWRNSAILRAVAMVAGTAMIGLFIASGVVGGGHGSHWSGPAWNTMWLYGLFAANAVSMFWTTHKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XT1</accession>
    <name>Q39XT1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Gmet_0701</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514092.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0701"/>
    <dbReference type="EnsemblBacteria" id="ABB30943">
        <property type="protein sequence ID" value="ABB30943"/>
        <property type="gene ID" value="Gmet_0701"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0701"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4564">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027641_0_0_7"/>
    <dbReference type="OMA" id="VVAYRYF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004010">
        <property type="entry name" value="Double_Cache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033480">
        <property type="entry name" value="sCache_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08269">
        <property type="entry name" value="dCache_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01049">
        <property type="entry name" value="Cache_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="13">
        <location>
            <begin position="372"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="12">
        <location>
            <begin position="444"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="655" mass="74138" checksum="1ED0FDE24A87C7CD" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XT8</accession>
    <name>Q39XT8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nitrogen regulatory protein P-II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">glnK</name>
        <name evidence="5" type="ordered locus">Gmet_0694</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the P(II) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514085.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0694"/>
    <dbReference type="EnsemblBacteria" id="ABB30936">
        <property type="protein sequence ID" value="ABB30936"/>
        <property type="gene ID" value="Gmet_0694"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0694"/>
    <dbReference type="eggNOG" id="COG0347">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082268_0_0_7"/>
    <dbReference type="OMA" id="LEMAIHT"/>
    <dbReference type="OrthoDB" id="2021322at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002187">
        <property type="entry name" value="N-reg_PII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017918">
        <property type="entry name" value="N-reg_PII_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002332">
        <property type="entry name" value="N-reg_PII_urydylation_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30115">
        <property type="entry name" value="PTHR30115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00543">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039144">
        <property type="entry name" value="GlnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00340">
        <property type="entry name" value="PIIGLNB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00938">
        <property type="entry name" value="P-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="SSF54913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00638">
        <property type="entry name" value="PII_GLNB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51343">
        <property type="entry name" value="PII_GLNB_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00496">
        <property type="entry name" value="PII_GLNB_UMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="O-UMP-tyrosine" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR039144-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602187-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="112" mass="12237" checksum="9E4A4BA7DA7C54F0" modified="2005-11-22" version="1">MKLIEAIIKPFKLDEVKDALTEIGVEGITVSEVKGFGRQKGHTELYRGAEYVVDFIPKVKIEIAVADEVVAKVVETIENTAKTGRIGDGKIFILPLDEAVRIRTGEKGAEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XY4</accession>
    <name>Q39XY4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 3">Methionine aminopeptidase</fullName>
            <shortName evidence="2">MAP</shortName>
            <shortName evidence="2">MetAP</shortName>
            <ecNumber evidence="2 3">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">map</name>
        <name evidence="5" type="ordered locus">Gmet_0648</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 2">Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 3">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="2 3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="2 3">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="2 3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30890.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365703.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0648"/>
    <dbReference type="EnsemblBacteria" id="ABB30890">
        <property type="protein sequence ID" value="ABB30890"/>
        <property type="gene ID" value="Gmet_0648"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0648"/>
    <dbReference type="eggNOG" id="COG0024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015857_0_1_7"/>
    <dbReference type="OMA" id="RGAESCY"/>
    <dbReference type="OrthoDB" id="1285136at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070084">
        <property type="term" value="P:protein initiator methionine removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M24" evidence="4">
        <location>
            <begin position="11"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30890.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="248" mass="26835" checksum="8EF96645FD70CB48" modified="2012-10-31" version="2">MIVLKSPQEIEKMRSAGQIVAEILDILRSEVRAGVTTLFLDGLAESEARKRKAVAAFKGYGGFPYALCCSLNEQVVHGMPSKRELVEGDIVSLDFGVVYSGYYADAAITVPVSKVTAQAERLVKVTEESLYCAIEAAVPGNRLSDISHAVQGYVERHGFSVVRDFVGHGIGKKLHESPQVPNFGEPGRGVRLKPGMVLAIEPMINERSYQVKVLADGWTAVTCDGGLSAHFEHTVAITEHGPEILSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y33</accession>
    <name>Q39Y33_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365692.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0598"/>
    <dbReference type="EnsemblBacteria" id="ABB30841">
        <property type="protein sequence ID" value="ABB30841"/>
        <property type="gene ID" value="Gmet_0598"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0598"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349435_0_0_7"/>
    <dbReference type="OMA" id="HIAQHDK"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223445" evidence="1">
        <location>
            <begin position="35"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="domain" description="PKD" evidence="2">
        <location>
            <begin position="572"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="806" mass="84409" checksum="C5352F9AED14A6D1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y99</accession>
    <name>Q39Y99_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane channel, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512228.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0532"/>
    <dbReference type="EnsemblBacteria" id="ABB30775">
        <property type="protein sequence ID" value="ABB30775"/>
        <property type="gene ID" value="Gmet_0532"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0532"/>
    <dbReference type="eggNOG" id="COG3746">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_695843_0_0_7"/>
    <dbReference type="OMA" id="YKGQFQM"/>
    <dbReference type="OrthoDB" id="1578713at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010870">
        <property type="entry name" value="Porin_O/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07396">
        <property type="entry name" value="Porin_O_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223622" evidence="1">
        <location>
            <begin position="27"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="415" mass="46367" checksum="2C3ED6047B6D53B0" modified="2005-11-22" version="1">MINMRKISTISGVALGTALLAGTAFAGPRITFGPEDQGALQIDYKGQFQMTVRDNGSGADGNSTTTNFNFRRNRLAFMGKYGDMVSLYVQTEFTEDPNVGTLGVSDQSANTEFQLLDAVVRFKLNDAFRVNVGKFKYGFSRENLEACEMPLTLDRSLFIRAPFVSTRDMGVGIWGNVLEDKIQYRADVMEGRKAGDEDGNGHKSPDSSFRYTFRGHVSLLDPESDYGYKGTYMGKKQVLTFGAAYQFEPDVVYGNPAAKSDKKDYQAWTVDGFFEYPVEAVGTFTLSAAYADYDLDKSYNTAINALTEPDKDAIGLNGEKNGWYMKAGYMLPNLPLQFFGRYEKWSFAMLNNIYDQDVTWYGGGVNYYIWGQNLKLTAEISRTDFDKEGVASGIQGTNLKTEDFTTFVTQLQLLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YK8</accession>
    <name>Q39YK8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512395.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0423"/>
    <dbReference type="EnsemblBacteria" id="ABB30666">
        <property type="protein sequence ID" value="ABB30666"/>
        <property type="gene ID" value="Gmet_0423"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0423"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044464_1_0_7"/>
    <dbReference type="OMA" id="QFHANHA"/>
    <dbReference type="OrthoDB" id="1398158at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Radical SAM core" evidence="1">
        <location>
            <begin position="10"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="293" mass="32924" checksum="9389ACC00B9FC8DB" modified="2005-11-22" version="1">MPTYIEPVFRPPSEARSLIFQITIGCSQNHCAYCGMYKMKRFALKPVEEVFAEIDGIPGRYRLHVDRVFLADGDALVYPFEGLCAILDRLAATFPNLTRVGSYASPNSLTTKSVDELRMLREKRLRIVYFGLESGDDATLAAVNKGFTAEKMAQEALKAREAGMKLSVTAILGVAGRGRSLDHARGTAAWVNRVNPEFFSLLTLFRRHNEEFVDTLDQCTRRELLAEAKELLAHLSPQRTILRSNHVSNFLELAGSYPKDRERLIASVEEAVAHLEGIPGYLDEVPEYGEEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YL6</accession>
    <name>Q39YL6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="19 20">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="19">D-alanine--D-alanine ligase</fullName>
                <ecNumber evidence="19">6.3.2.4</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="19">D-Ala-D-Ala ligase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="19">D-alanylalanine synthetase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="20">Cell division protein FtsQ</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="19 24" type="primary">ddl</name>
        <name evidence="20 24" type="synonym">ftsQ</name>
        <name evidence="24" type="ordered locus">Gmet_0415</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 19">Cell wall formation.</text>
    </comment>
    <comment type="function">
        <text evidence="20">Essential cell division protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>ATP + 2 D-alanine = ADP + D-alanyl-D-alanine + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11224"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57416"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="19">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Cell inner membrane</location>
            <topology evidence="20">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="20">Localizes to the division septum.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the D-alanine--D-alanine ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the FtsQ/DivIB family. FtsQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.4" evidence="19"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512387.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0415"/>
    <dbReference type="EnsemblBacteria" id="ABB30658">
        <property type="protein sequence ID" value="ABB30658"/>
        <property type="gene ID" value="Gmet_0415"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0415"/>
    <dbReference type="eggNOG" id="COG1181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_436005_0_0_7"/>
    <dbReference type="OrthoDB" id="764798at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008716">
        <property type="term" value="F:D-alanine-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090529">
        <property type="term" value="P:cell septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043093">
        <property type="term" value="P:FtsZ-dependent cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00047">
        <property type="entry name" value="Dala_Dala_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00911">
        <property type="entry name" value="FtsQ_subfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005548">
        <property type="entry name" value="Cell_div_FtsQ/DivIB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000291">
        <property type="entry name" value="D-Ala_lig_Van_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005905">
        <property type="entry name" value="D_ala_D_ala"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011095">
        <property type="entry name" value="Dala_Dala_lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011127">
        <property type="entry name" value="Dala_Dala_lig_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026579">
        <property type="entry name" value="FtsQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045335">
        <property type="entry name" value="FtsQ_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034746">
        <property type="entry name" value="POTRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013685">
        <property type="entry name" value="POTRA_FtsQ_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07478">
        <property type="entry name" value="Dala_Dala_lig_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01820">
        <property type="entry name" value="Dala_Dala_lig_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03799">
        <property type="entry name" value="FtsQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08478">
        <property type="entry name" value="POTRA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01205">
        <property type="entry name" value="D_ala_D_alaTIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00843">
        <property type="entry name" value="DALA_DALA_LIGASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00844">
        <property type="entry name" value="DALA_DALA_LIGASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51779">
        <property type="entry name" value="POTRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17 20" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 20 24" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 20" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 19" id="KW-0133">Cell shape</keyword>
    <keyword evidence="18 19" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 19 24" id="KW-0436">Ligase</keyword>
    <keyword evidence="16 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 19" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="107"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="POTRA" evidence="23">
        <location>
            <begin position="418"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ABB30658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="627" mass="68402" checksum="5037F39115EEAC7C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YM4</accession>
    <name>MURE_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase</fullName>
            <ecNumber evidence="1">6.3.2.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Meso-A2pm-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Meso-diaminopimelate-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-MurNAc-tripeptide synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramyl-tripeptide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murE</name>
        <name type="ordered locus">Gmet_0407</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + meso-2,6-diaminoheptanedioate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:23676"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family. MurE subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.13" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512379.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YM4"/>
    <dbReference type="SMR" id="Q39YM4"/>
    <dbReference type="STRING" id="269799.Gmet_0407"/>
    <dbReference type="EnsemblBacteria" id="ABB30650">
        <property type="protein sequence ID" value="ABB30650"/>
        <property type="gene ID" value="Gmet_0407"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0407"/>
    <dbReference type="eggNOG" id="COG0769">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022291_4_1_7"/>
    <dbReference type="OMA" id="CFMEVSS"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008765">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00208">
        <property type="entry name" value="MurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005761">
        <property type="entry name" value="UDP-N-AcMur-Glu-dNH2Pim_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01085">
        <property type="entry name" value="murE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000012353" description="UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase">
        <location>
            <begin position="1"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Meso-diaminopimelate recognition motif">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="110"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="152"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="385"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="476"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>meso-2,6-diaminoheptanedioate</name>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00208"/>
        </source>
    </evidence>
    <sequence length="511" mass="54733" checksum="8700F06EAB4E3E6B" modified="2005-11-22" version="1">MRLEDLARVINPSEAGGSLALEIEGLYCDSRQVRSGGLFFALRGVATDGHDYIVASRDRGAVAVVVEDPSRVPEGMTWLKVDDARLAMSRAAAAFYGNPTDGIPVVGITGTNGKTTTTYLVEAVMARAGIPVAVLGTISYRFGDKTIPAPHTTPESVDLQRTIRDLVDRGAQGVVMEVSSHALEQRRVDGCRFDVGVFTNLTRDHLDYHRDMESYFESKARLFTELLAADDTKPRRAAVINVDDPYGARLASDAVAPVVSYGLSPSVMVRAEMVTFSVDGISGTLVTPLGTIPFHSRLLGRFNLYNILAAVAAGVALGLSPDAIRGGIEGDVRVPGRLERVDNDHGITVLVDYAHTGDALENVLKTVAEIATGRIITVFGCGGDRDRGKRPVMGEIAGRFSDLSIVTSDNPRTEDAGAIIGEILGGIRSLGLREYGAEELITGFDAKGFAAVESRREAIRLAARVARPGDVLLLAGKGHEDYQIIGTMKHHFDDREEVAAAFRELSSKGQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YQ2</accession>
    <name>Q39YQ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0379</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512351.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0379"/>
    <dbReference type="EnsemblBacteria" id="ABB30622">
        <property type="protein sequence ID" value="ABB30622"/>
        <property type="gene ID" value="Gmet_0379"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0379"/>
    <dbReference type="eggNOG" id="COG3872">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038140_0_0_7"/>
    <dbReference type="OMA" id="LFQYHGA"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010787">
        <property type="entry name" value="DUF1385"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07136">
        <property type="entry name" value="DUF1385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="316" mass="35230" checksum="5F53877769DAA9E1" modified="2005-11-22" version="1">MTRWFRLLLVQLLILAERINVGGQAVLEGVMMRAPRSMAIAVRRPSGEIAVKREEVPPLSERFPIVKLPILRGAVALFSSLIIGLKALNFSANEALAEEEEKEELSSWAMGGTMAVALGFGVLLFFVLPLYLTKLLVPVIGQSNIMFNLVDGIIRVAVFLLYIVSISRMKDIQRVFEYHGAEHKTIFAFEAGEELSAATVQKYSRLHPRCGTSFLLIVMLVSIVIFSLIPKLWPFWMKAGARVALLPVIAGVSYEFLKWSAKNDRHPLVRLIIAPGLALQRLTTREPDDSQVEVAIRSMTEALEENGGYKDDRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YS7</accession>
    <name>Q39YS7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Penicillin-binding protein 1A</fullName>
            <ecNumber evidence="7">2.4.1.129</ecNumber>
            <ecNumber evidence="6">3.4.16.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="primary">mrcA</name>
        <name evidence="22" type="ordered locus">Gmet_0354</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>[GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1-&gt;4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23708"/>
            <dbReference type="Rhea" id="RHEA-COMP:9602"/>
            <dbReference type="Rhea" id="RHEA-COMP:9603"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60033"/>
            <dbReference type="ChEBI" id="CHEBI:78435"/>
            <dbReference type="EC" id="2.4.1.129"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the transpeptidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the glycosyltransferase 51 family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.129" evidence="7"/>
    <dbReference type="EC" id="3.4.16.4" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512325.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0354"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30597">
        <property type="protein sequence ID" value="ABB30597"/>
        <property type="gene ID" value="Gmet_0354"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0354"/>
    <dbReference type="eggNOG" id="COG5009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_2_4_7"/>
    <dbReference type="OMA" id="LAQMAMI"/>
    <dbReference type="OrthoDB" id="652304at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008658">
        <property type="term" value="F:penicillin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008955">
        <property type="term" value="F:peptidoglycan glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009002">
        <property type="term" value="F:serine-type D-Ala-D-Ala carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031376">
        <property type="entry name" value="PCB_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001460">
        <property type="entry name" value="PCN-bd_Tpept"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17092">
        <property type="entry name" value="PCB_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00905">
        <property type="entry name" value="Transpeptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0046">Antibiotic resistance</keyword>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="20">
        <location>
            <begin position="75"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="PCB_OB" evidence="21">
        <location>
            <begin position="337"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="19">
        <location>
            <begin position="456"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Transpeptidase" evidence="19">
        <location>
            <begin position="668"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="786"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="807"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00018638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF17092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ABB30597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="841" mass="91043" checksum="6FB3109C5D1D1D31" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z62</accession>
    <name>Q39Z62_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nucleotidyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512805.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0216"/>
    <dbReference type="EnsemblBacteria" id="ABB30462">
        <property type="protein sequence ID" value="ABB30462"/>
        <property type="gene ID" value="Gmet_0216"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0216"/>
    <dbReference type="eggNOG" id="COG1708">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_9_3_7"/>
    <dbReference type="OMA" id="LFYTKEV"/>
    <dbReference type="OrthoDB" id="1831955at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041633">
        <property type="entry name" value="Polbeta"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18765">
        <property type="entry name" value="Polbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polbeta" evidence="2">
        <location>
            <begin position="8"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="103" mass="11892" checksum="DE974FE6FEB2B28A" modified="2005-11-22" version="1">MATSVDIQNISNQIRREFAPRKIILFGSHSWGTPSDDSDVDLLVIADFEGKPWRFAVEIRERIRATIPLDLMVRTPEQLRERLAKHDMLLTEIVDRGTVLYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z76</accession>
    <name>Q39Z76_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0202</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512791.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0202"/>
    <dbReference type="EnsemblBacteria" id="ABB30448">
        <property type="protein sequence ID" value="ABB30448"/>
        <property type="gene ID" value="Gmet_0202"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0202"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="DINDYRH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="15"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="152"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="374" mass="41368" checksum="4D059B44E9AA8DA3" modified="2005-11-22" version="1">MDVVAKFQAERDVKTILVVDDEAVIRDLCARALKGYRVLQAADGEEALRLFEKGGVDVILTDVMMPKINGIELLRRLKDLEPTIVVIVMTGYAEKEIILNALKADADDFITKPLNILQLKTAVDKALDKKALKEELANLKSMDRLKSNFLSLISHKFRTPITAISLFLQNLASGVCDPDDPDSRENLKLICGQSRYLENLVAELLVFSRFLAAGEELHLEPCSLPEIIRPLVASSKEATAKPGVVASFDLEQLSPLSLDREKIAFAIGQVIDNAFKFSRETGTVSFSLREDNVACRLTVEDEGIGIPKEELPKIFEKFYQVDLEGAGQIRGFGLGLFYAREFVKLHGGTITVESEPEKGTRVTVLLPLHSSITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z92</accession>
    <name>Q39Z92_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512775.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0186"/>
    <dbReference type="EnsemblBacteria" id="ABB30432">
        <property type="protein sequence ID" value="ABB30432"/>
        <property type="gene ID" value="Gmet_0186"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0186"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_7"/>
    <dbReference type="OMA" id="IEGPCHH"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="296" mass="32906" checksum="722776BC6ED5E559" modified="2005-11-22" version="1">MAITVRQLEIFEKVARCEHVTQASSQLFITQSAVSMAIAELERLAGAPLFERHGKRLLLNDRGRKILPEAVEVIRRIRAIEQFLEDSAGEPRGVLTIGASTTIGNYILPDIVAEFSRNYPQAKVLLTIANAQQIENALENGELDLGLIEGIPHSRVLDTSPWKNDELVVVVGKGHPWGGRKKASVEMLHGAPWIMREKGSGTREVFEAAMARKGIEFSIALELGHTEAIKKATEAGLGVGCLSKIAVERELEQGWLVEVACSLDLRRTLSVQTRECRYQTRLLQEFLSLLNQYRDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZB1</accession>
    <name>Q39ZB1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0166</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512753.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0166"/>
    <dbReference type="EnsemblBacteria" id="ABB30413">
        <property type="protein sequence ID" value="ABB30413"/>
        <property type="gene ID" value="Gmet_0166"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0166"/>
    <dbReference type="eggNOG" id="ENOG5033AUV">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2382021_0_0_7"/>
    <dbReference type="OMA" id="EGPMEEA"/>
    <dbReference type="OrthoDB" id="2097902at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028037">
        <property type="entry name" value="Antitoxin_Rv0909/MT0933"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001058">
        <property type="entry name" value="Synuclein"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14013">
        <property type="entry name" value="MT0933_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01211">
        <property type="entry name" value="SYNUCLEIN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223480" evidence="2">
        <location>
            <begin position="19"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="94" mass="9721" checksum="68BFE65C666730FD" modified="2005-11-22" version="1">MKHLKGMVVLLAAVVAMSAVGCKKKEVGPAEKAGQEIDKAVEKAGEGLGKATEKSKEAVEKAGEKVGEAVDKSKEAVDKAADKTKDAVKDATQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZH4</accession>
    <name>Q39ZH4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Radical SAM domain iron-sulfur cluster-binding oxidoreductase with cobalamin-binding-like domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0101</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514106.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0101"/>
    <dbReference type="EnsemblBacteria" id="ABB30350">
        <property type="protein sequence ID" value="ABB30350"/>
        <property type="gene ID" value="Gmet_0101"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0101"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030409_0_0_7"/>
    <dbReference type="OMA" id="YPNHLDI"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B12-binding" evidence="2">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="3">
        <location>
            <begin position="178"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="624" mass="67966" checksum="896BD3A8413674F0" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>J7LWA8</accession>
    <name>J7LWA8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3602"/>
    <dbReference type="EnsemblBacteria" id="AFR42820">
        <property type="protein sequence ID" value="AFR42820"/>
        <property type="gene ID" value="Gmet_3602"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3602"/>
    <dbReference type="HOGENOM" id="CLU_2395510_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="93" mass="10302" checksum="B08B20B12363A8D6" modified="2012-10-31" version="1">MTAIIASRVVLGPFVVGCVVEMLAVEKINNGASGQKRDSSRNREHQNNFSHINLLCFRAWCIGAEPLCKIISLPDGCIKNGALRRRSQRVRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="29" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYD9</accession>
    <name>J7LYD9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1023"/>
    <dbReference type="EnsemblBacteria" id="AFR42808">
        <property type="protein sequence ID" value="AFR42808"/>
        <property type="gene ID" value="Gmet_1023"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1023"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2117519_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="114" mass="12704" checksum="0E17641EB2CE8CF1" modified="2012-10-31" version="1">MRVLIPRTEQIERALASARTEPTLFPQHLPPDIRVQIARAAVEQPVSGAGPHRITQSLPRLQDFRETVLARAEKEYLRDLLSLTGSDLKEACRIAGLSLSRLYALLSKHGIKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYF0</accession>
    <name>J7LYF0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511582.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3600"/>
    <dbReference type="EnsemblBacteria" id="AFR42818">
        <property type="protein sequence ID" value="AFR42818"/>
        <property type="gene ID" value="Gmet_3600"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3600"/>
    <dbReference type="HOGENOM" id="CLU_2915954_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="61" mass="6736" checksum="D1054BA730D72A47" modified="2012-10-31" version="1">MHARTERILWMLIASVALLMFVATLRTTGNHLSLERERSAVIGLVSTQQQGEGTLTEVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PQ6</accession>
    <name>Q39PQ6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribonuclease P protein component</fullName>
            <shortName evidence="6">RNase P protein</shortName>
            <shortName evidence="6">RNaseP protein</shortName>
            <ecNumber evidence="6">3.1.26.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Protein C5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">rnpA</name>
        <name evidence="7" type="ordered locus">Gmet_3563</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.</text>
            <dbReference type="EC" id="3.1.26.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RnpA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.5" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33768.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366204.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3563"/>
    <dbReference type="EnsemblBacteria" id="ABB33768">
        <property type="protein sequence ID" value="ABB33768"/>
        <property type="gene ID" value="Gmet_3563"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3563"/>
    <dbReference type="eggNOG" id="COG0594">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117179_11_0_7"/>
    <dbReference type="OMA" id="RWVREIF"/>
    <dbReference type="OrthoDB" id="2014742at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00227">
        <property type="entry name" value="RNase_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000100">
        <property type="entry name" value="RNase_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020539">
        <property type="entry name" value="RNase_P_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33992">
        <property type="entry name" value="PTHR33992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00825">
        <property type="entry name" value="Ribonuclease_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00188">
        <property type="entry name" value="rnpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00648">
        <property type="entry name" value="RIBONUCLEASE_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33768.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="116" mass="13351" checksum="12D933D2A04E558D" modified="2012-10-31" version="2">MFTFTKDERLLKRVDFLRLSESSRKISTPCFLVLWAAGPDPACRIGITVSRKVGNAVTRNRIKRLVREYYRLHKALFPPLDINIIARRGADKLDYQGVCKELDRVVERLAGLTRSC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PR1</accession>
    <name>RSMG_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosomal RNA small subunit methyltransferase G</fullName>
            <ecNumber evidence="1">2.1.1.170</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">16S rRNA 7-methylguanosine methyltransferase</fullName>
            <shortName evidence="1">16S rRNA m7G methyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rsmG</name>
        <name type="ordered locus">Gmet_3558</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically methylates the N7 position of guanine in position 527 of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(527) in 16S rRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(527) in 16S rRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42732"/>
            <dbReference type="Rhea" id="RHEA-COMP:10209"/>
            <dbReference type="Rhea" id="RHEA-COMP:10210"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.170"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.170" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513714.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39PR1"/>
    <dbReference type="SMR" id="Q39PR1"/>
    <dbReference type="STRING" id="269799.Gmet_3558"/>
    <dbReference type="EnsemblBacteria" id="ABB33763">
        <property type="protein sequence ID" value="ABB33763"/>
        <property type="gene ID" value="Gmet_3558"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3558"/>
    <dbReference type="eggNOG" id="COG0357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065341_2_0_7"/>
    <dbReference type="OMA" id="ICFPHLH"/>
    <dbReference type="OrthoDB" id="1590629at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070043">
        <property type="term" value="F:rRNA (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00074">
        <property type="entry name" value="16SrRNA_methyltr_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003682">
        <property type="entry name" value="rRNA_ssu_MeTfrase_G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31760">
        <property type="entry name" value="PTHR31760"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02527">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003078">
        <property type="entry name" value="GidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00138">
        <property type="entry name" value="rsmG_gidB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000010151" description="Ribosomal RNA small subunit methyltransferase G">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="129"/>
            <end position="130"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00074"/>
        </source>
    </evidence>
    <sequence length="220" mass="23988" checksum="D0D4B8297A69ACC7" modified="2005-11-22" version="1">MDQEAKDLLVRGAAQLGVELTSAQVGKFALFAAELRKWNRKINLTAITTEREIALKHFVDSLSLCRAVGKGGKLLDLGSGGGFPVIPFAILHPKSEVVSVDAVEKKIIFQRHMGRLLGLSCFQSIHARGEELAGRFAGHFDWIVSRAFSDIPTFVRMALPLLRPNGAIVAMKGQGGREEAETSRPALEVLGVEIRQVLEFPLPFSGDGRSLIVMGRKNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PT5</accession>
    <name>Q39PT5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-inducible transcription repressor HrcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 8" type="primary">hrcA</name>
        <name evidence="8" type="ordered locus">Gmet_3534</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the HrcA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513690.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3534"/>
    <dbReference type="EnsemblBacteria" id="ABB33739">
        <property type="protein sequence ID" value="ABB33739"/>
        <property type="gene ID" value="Gmet_3534"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3534"/>
    <dbReference type="eggNOG" id="COG1420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050019_0_0_7"/>
    <dbReference type="OMA" id="DYPGTMG"/>
    <dbReference type="OrthoDB" id="1510750at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00081">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002571">
        <property type="entry name" value="HrcA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021153">
        <property type="entry name" value="HrcA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005104">
        <property type="entry name" value="WHTH_HrcA_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023120">
        <property type="entry name" value="WHTH_transcript_rep_HrcA_IDD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34824">
        <property type="entry name" value="PTHR34824"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01628">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03444">
        <property type="entry name" value="HrcA_DNA-bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005485">
        <property type="entry name" value="HrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00331">
        <property type="entry name" value="hrcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0678">Repressor</keyword>
    <keyword evidence="3 5" id="KW-0346">Stress response</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HrcA_DNA-bdg" evidence="7">
        <location>
            <begin position="5"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="HrcA" evidence="6">
        <location>
            <begin position="109"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="343" mass="38184" checksum="7EBCF30545AF7697" modified="2005-11-22" version="1">MGEGLSERNKKILEAIIEDYIVTAEPVGSRAVTRRHGLNLSPATVRNAMADLEEMGLLTSPHTSAGRVPTDRAYRFYVDSLLAVGRIDKAERERIRKRYTGAGRDMGAVLHETTRLLSSVSHYMGIVLAPRFSSTTLRHMEFVKLGGRRILAILVADNGAVQNRLIESEEEFAEADLVRMSNYLNELLQGLPVAQVRTRILEEMRNEKVLYDTLFSRALKLSEQTIVEGSAQIFMEGQTNILDQPEFADVGRMKDVFRAFEEKNQLVNLLDRCISAQGVQIFIGSETHLNHMEGLSVITSAYVSGKNTLGVLGVIGPTRMGYGKVIPIVDYTAKLVSKLLEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PW6</accession>
    <name>Q39PW6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-threonine aldolase</fullName>
            <ecNumber evidence="3">4.1.2.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ltaE</name>
        <name evidence="5" type="ordered locus">Gmet_3503</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-allo-threonine = acetaldehyde + glycine</text>
            <dbReference type="Rhea" id="RHEA:26209"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58585"/>
            <dbReference type="EC" id="4.1.2.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-threonine = acetaldehyde + glycine</text>
            <dbReference type="Rhea" id="RHEA:19625"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.1.2.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the threonine aldolase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.48" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513659.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3503"/>
    <dbReference type="EnsemblBacteria" id="ABB33708">
        <property type="protein sequence ID" value="ABB33708"/>
        <property type="gene ID" value="Gmet_3503"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3503"/>
    <dbReference type="eggNOG" id="COG2008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049619_0_0_7"/>
    <dbReference type="OMA" id="ETDCEVF"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008732">
        <property type="term" value="F:L-allo-threonine aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026273">
        <property type="entry name" value="Low_specificity_L-TA_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038940">
        <property type="entry name" value="Low_specificity_LTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta_elim_lyase" evidence="4">
        <location>
            <begin position="12"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR038940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="353" mass="38295" checksum="81616A356DF699EA" modified="2005-11-22" version="1">MTDGVDTVKKYQFASDNYAGICPEALQAMEAANRGYACSYGDDPWTEKACRLLRDLFETDCEVFFVFNGTAANSLALASLCHSYNSIICHETSHVETDECGASEFFSNGTKILLVSGGHGKVDLEAVEHTVKRRTDIHYPKPKALSITQATELGTLYSVEELQAVGELARRLDLKLHMDGARFANAVATLGAAPAELTWKAGVDVLCFGGTKNGMAVGEAIIFFNRDLASEFDYRCKQAGQLASKMRFLAAPWVGMLESGAWLTRAANANACAARLEARLREIPGVGIRFPRQANSVFADFSPEVAAALQERGWHFYSFIGSGGARFMCSWETTEADVDLLAADLSAVASRHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q02</accession>
    <name>Q39Q02_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ybhF-N2</name>
        <name evidence="5" type="ordered locus">Gmet_3463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513914.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3463"/>
    <dbReference type="EnsemblBacteria" id="ABB33672">
        <property type="protein sequence ID" value="ABB33672"/>
        <property type="gene ID" value="Gmet_3463"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3463"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="IMCAFLV"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="305" mass="33848" checksum="6A9B547ABCBC1FFA" modified="2005-11-22" version="1">MNPVIRTDNLTKGFGPLTAVDGLTLEIGKGELFGLVGPDGAGKTTTMRLLTAIMEPSSGEAWVAGHSVRTEGERIKERIGYMSQRFGLYEELTVMENITFYADLYEVPKRERPPRFERLLGFSNLTPFRDRLAGKLSGGMKQKLGLACALIHTPEILFLDEPTNGVDPVSRRDFWRILYDLLKEGITIFVSTAYLDEAERCTRVGLMHRGRILVDDTPARIKGSLGFPMVELWTGEARLAEEIVRGTDGVRSVSIYGDKLHVSLERSGIEELVAGRLKGEGIEVKGHRPILPSLEDVFIAMVEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q31</accession>
    <name>Q39Q31_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heterodisulfide oxidoreductase, NAD(P)H oxidoreductase subunit F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">hdrF</name>
        <name evidence="6" type="ordered locus">Gmet_3431</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="4">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PyrK family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514659.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3431"/>
    <dbReference type="EnsemblBacteria" id="ABB33643">
        <property type="protein sequence ID" value="ABB33643"/>
        <property type="gene ID" value="Gmet_3431"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3431"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_1_7"/>
    <dbReference type="OMA" id="NTARYGK"/>
    <dbReference type="OrthoDB" id="1109542at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="9"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="281" mass="31038" checksum="2BE4427137289523" modified="2005-11-22" version="1">MCDHSKNIYLPQLATIKEIVDETADIRTFRLEFQDETVRENFTFRAGQFAEYSAFGAGEATFCIASAPTRKGYIECCFRAVGRVTEALRQLEVGDAIGVRGPYGNSFPIEEFFGRNLVFVAGGIALPPLRTLIGQCLDWREKFGDITIVYGARTEGDLVYKRELTEWEERSDVRLVKTVDPGGNSPDWDGKVGFVPTILEEAAPAADNTIALVCGPPIMIKFTLPVLEKLGFSDNAIYTTLENRMKCGLGKCGRCNVGNVYVCKDGPVFTAAQVKAMPQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q62</accession>
    <name>Q39Q62_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility pilus retraction ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilT-3</name>
        <name evidence="3" type="ordered locus">Gmet_3400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514207.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3400"/>
    <dbReference type="EnsemblBacteria" id="ABB33612">
        <property type="protein sequence ID" value="ABB33612"/>
        <property type="gene ID" value="Gmet_3400"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3400"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_7"/>
    <dbReference type="OMA" id="QVTHREV"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="356" mass="39708" checksum="D467D1001BBD0F9C" modified="2005-11-22" version="1">MARIDTLFKMLKDQGASDLHLSSGAPPIFRLHGEMARQNFKPLTHDELKAILYEILTEKQKADFEERHDLDFAYAIPGLARFRGNYMLTHRGIAAVFRIIPSKILSADDLSLPDGVRRMTLFKKGLVLVTGPTGSGKSTTLAAMIDLINATRKEHILTLEDPLEFIHENKMSLLNQRQIGEHSMTFTAALRAALREDPDVILVGEMRDLETIGLAMSAAETGHLVFGTLHTNSAAKTIDRIIDVFPTDQQEQTRAMLSESLKGVVCQQLLKTADGKGRVAALEIMLGTPAIGNLIREGKTFQIPSIIQTAKRDGMQLMDQHLLDLFKTKRITAEEAYRCAQDKKQFEQYLAEKPAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-11" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QB5</accession>
    <name>NUOI2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit I 2</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit I 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit I 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoI2</name>
        <name type="ordered locus">Gmet_3347</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512573.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QB5"/>
    <dbReference type="SMR" id="Q39QB5"/>
    <dbReference type="STRING" id="269799.Gmet_3347"/>
    <dbReference type="EnsemblBacteria" id="ABB33559">
        <property type="protein sequence ID" value="ABB33559"/>
        <property type="gene ID" value="Gmet_3347"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3347"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067218_5_1_7"/>
    <dbReference type="OMA" id="RGDLYYT"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10849">
        <property type="entry name" value="PTHR10849"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000245708" description="NADH-quinone oxidoreductase subunit I 2">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 1" evidence="1">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type 2" evidence="1">
        <location>
            <begin position="81"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01351"/>
        </source>
    </evidence>
    <sequence length="131" mass="15085" checksum="CAD66176DBC1B6D3" modified="2005-11-22" version="1">MIMPLINGLKITLKHMFMKPVTLQYPDERPTPSPNFRGLHALKVSHSKAKCVCCYLCPTVCPAKCITVEAGEDQEHNKYAERYEIDMLRCIFCGYCVEACPVDALKMTGEFELANYKREDFVFVKERLLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QD2</accession>
    <name>Q39QD2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Periplasmically oriented, membrane-bound [NiFe]-hydrogenase maturation protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hyaP</name>
        <name evidence="2" type="ordered locus">Gmet_3329</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A31 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512553.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3329"/>
    <dbReference type="EnsemblBacteria" id="ABB33542">
        <property type="protein sequence ID" value="ABB33542"/>
        <property type="gene ID" value="Gmet_3329"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3329"/>
    <dbReference type="eggNOG" id="COG0680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099037_0_0_7"/>
    <dbReference type="OMA" id="MGAKKMS"/>
    <dbReference type="OrthoDB" id="1858718at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023430">
        <property type="entry name" value="Pept_HybD-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000671">
        <property type="entry name" value="Peptidase_A31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30302">
        <property type="entry name" value="PTHR30302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01750">
        <property type="entry name" value="HycI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00446">
        <property type="entry name" value="HYDRGNUPTAKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53163">
        <property type="entry name" value="SSF53163"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00072">
        <property type="entry name" value="hydrog_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="172" mass="18340" checksum="56E44017517B27AF" modified="2005-11-22" version="1">MSILVLGIGNLIMTDDGAGVRVAQRLMDGCRFPEGVTVMDGGTLGLDLLPYLDGVERLLLVDAVETGGPPGTVVRLAGEEIPVAFRTKLSPHQMGLQDLLAVAEFQGSCPVEMVLWGVQPESVELGMELTPAVAAQVDHLVEKVLAELALWGVVPEPLDPEKCTRNTEQQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QL7</accession>
    <name>Q39QL7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lactate racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">larA</name>
        <name evidence="2" type="ordered locus">Gmet_3244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512682.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3244"/>
    <dbReference type="EnsemblBacteria" id="ABB33457">
        <property type="protein sequence ID" value="ABB33457"/>
        <property type="gene ID" value="Gmet_3244"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3244"/>
    <dbReference type="eggNOG" id="COG3875">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050189_0_0_7"/>
    <dbReference type="OMA" id="GSVEPHY"/>
    <dbReference type="OrthoDB" id="313921at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050043">
        <property type="term" value="F:lactate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043166">
        <property type="entry name" value="LarA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018657">
        <property type="entry name" value="LarA-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09861">
        <property type="entry name" value="Lar_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lar_N" evidence="1">
        <location>
            <begin position="5"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="420" mass="46174" checksum="CC3FF04FCFF8ADAE" modified="2005-11-22" version="1">MDLHYGDTSFTLTLPPERLLGVIRPEIGVPVDRPETIIAAALDRCAETIGTFRPGERVVIVTSDITRYTGSELYLPLLVERLVATGIRERDMEILVALGIHRKQTEHEHQKIAGPLHGRIRIVDHDCDDPGQLAFIGRTSNGIEVTVNRRVVEADRVILTGTIGFHYFAGFGGGRKSILPGVASRATCMASHFAVLNPGEGTGKNPLAVTGNLEGNPVHGAMVEACAMVEPDFILNTVLSPDKRIMAAFAGPWREAHEEGCRFYAERFAWPLREKADLVVVSCGGFPKDINVIQSHKAMEYGSQALKEGGVMVLLAQCRDGYGNATFFDWFRFRDLGAFETRLRSHYEINGQTAYSLLQKAQKFRVILVSELPPEEVRTMGMTPARSLDEAMAQAAEFLPADYTAYVIPEGGTVLPVIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QZ4</accession>
    <name>Q39QZ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3116</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3116"/>
    <dbReference type="EnsemblBacteria" id="ABB33330">
        <property type="protein sequence ID" value="ABB33330"/>
        <property type="gene ID" value="Gmet_3116"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3116"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_386741_0_0_7"/>
    <dbReference type="OMA" id="ARENREH"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223273" evidence="2">
        <location>
            <begin position="23"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="221"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="700" mass="77457" checksum="E6AF3011503772A2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RA1</accession>
    <name>DTD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-aminoacyl-tRNA deacylase</fullName>
            <shortName evidence="1">DTD</shortName>
            <ecNumber evidence="1">3.1.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gly-tRNA(Ala) deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dtd</name>
        <name type="ordered locus">Gmet_3008</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>glycyl-tRNA(Ala) + H2O = glycine + H(+) + tRNA(Ala)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a D-aminoacyl-tRNA + H2O = a D-alpha-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DTD family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514320.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RA1"/>
    <dbReference type="SMR" id="Q39RA1"/>
    <dbReference type="STRING" id="269799.Gmet_3008"/>
    <dbReference type="EnsemblBacteria" id="ABB33223">
        <property type="protein sequence ID" value="ABB33223"/>
        <property type="gene ID" value="Gmet_3008"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3008"/>
    <dbReference type="eggNOG" id="COG1490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076901_1_0_7"/>
    <dbReference type="OMA" id="GVFQAHM"/>
    <dbReference type="OrthoDB" id="1862614at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051499">
        <property type="term" value="F:D-aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043908">
        <property type="term" value="F:Ser(Gly)-tRNA(Ala) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00563">
        <property type="entry name" value="Dtyr_deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="PTHR10472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="SSF69500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00256">
        <property type="entry name" value="TIGR00256"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000259284" description="D-aminoacyl-tRNA deacylase">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Gly-cisPro motif, important for rejection of L-amino acids" evidence="1">
        <location>
            <begin position="137"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00518"/>
        </source>
    </evidence>
    <sequence length="151" mass="16116" checksum="28AA9EBB1B22C995" modified="2005-11-22" version="1">MKAVIQRVSEARVVVDGEVVGAIERGILVLLGVEKGDAERDAAWLAEKVAGLRIFEDEAGKMNLSVREVTGGILAVSQFTLAGNCAKGRRPSFDTAAPPDEGKRLYGRFVDFMRETGIPTATGIFQADMKVHLVNDGPVTFILESPKATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RB7</accession>
    <name>Q39RB7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Diaminopimelate epimerase</fullName>
            <shortName evidence="8">DAP epimerase</shortName>
            <ecNumber evidence="4 8">5.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">PLP-independent amino acid racemase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">dapF</name>
        <name evidence="10" type="ordered locus">Gmet_2992</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2S,6S)-2,6-diaminoheptanedioate = meso-2,6-diaminoheptanedioate</text>
            <dbReference type="Rhea" id="RHEA:15393"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="ChEBI" id="CHEBI:57791"/>
            <dbReference type="EC" id="5.1.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; DL-2,6-diaminopimelate from LL-2,6-diaminopimelate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the diaminopimelate epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.7" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514483.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2992"/>
    <dbReference type="EnsemblBacteria" id="ABB33207">
        <property type="protein sequence ID" value="ABB33207"/>
        <property type="gene ID" value="Gmet_2992"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2992"/>
    <dbReference type="eggNOG" id="COG0253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053306_3_0_7"/>
    <dbReference type="OMA" id="HVAMRVH"/>
    <dbReference type="OrthoDB" id="1921631at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00025"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008837">
        <property type="term" value="F:diaminopimelate epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00197">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018510">
        <property type="entry name" value="DAP_epimerase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001653">
        <property type="entry name" value="DAP_epimerase_DapF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31689">
        <property type="entry name" value="PTHR31689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01678">
        <property type="entry name" value="DAP_epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00652">
        <property type="entry name" value="DapF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01326">
        <property type="entry name" value="DAP_EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 8" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="72"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="8">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Could be important to modulate the pK values of the two catalytic cysteine residues" evidence="8">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="282" mass="30849" checksum="4DF6313049864BA5" modified="2005-11-22" version="1">MKFTKMHGAGNDYVYVNCFEERVDNPEQVAIKVSNRNFGIGSDGLILIMPSDKADVRMRMFNSDGSESEMCGNGIRCVAKYAYDHGIVSKKEITAETGAGILTLQLVPGADGKIEKVRVNMGVPRLKRAEIPMAGEPADGQIVSQPLNILHTTFNITCVSMGNPHCVIFVDDVESFQVEKYGPLIENHELFPRRTNVEFVQIISRTEVRQRTWERGAGETLACGTGASAVCVAGALNCLTEKKILNHLSGGDLELEWADDGFLYMTGPATEVFSGEIDLAKL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RG4</accession>
    <name>SYGA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="1">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyQ</name>
        <name type="ordered locus">Gmet_2942</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512878.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RG4"/>
    <dbReference type="SMR" id="Q39RG4"/>
    <dbReference type="STRING" id="269799.Gmet_2942"/>
    <dbReference type="EnsemblBacteria" id="ABB33160">
        <property type="protein sequence ID" value="ABB33160"/>
        <property type="gene ID" value="Gmet_2942"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2942"/>
    <dbReference type="eggNOG" id="COG0752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057066_1_0_7"/>
    <dbReference type="OMA" id="SYYQFQV"/>
    <dbReference type="OrthoDB" id="676868at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00733">
        <property type="entry name" value="GlyRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00254">
        <property type="entry name" value="Gly_tRNA_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002310">
        <property type="entry name" value="Gly-tRNA_ligase_asu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02091">
        <property type="entry name" value="tRNA-synt_2e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01044">
        <property type="entry name" value="TRNASYNTHGA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00388">
        <property type="entry name" value="glyQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000047424" description="Glycine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00254"/>
        </source>
    </evidence>
    <sequence length="291" mass="33389" checksum="7B5CF8DF705A1038" modified="2005-11-22" version="1">MTFQDLILSLQGYWAKQGCVIQQPYDTEKGAGTFNPATFLRVLGPEPWNVAYVEPSRRPTDGRYGENPNRLQHYYQFQVIMKPSPLNILDLYLDSLRAFGIDPQKHDIRFVEDDWESPTLGAWGLGWEVWLDGMEITQFTYFQQAGGIDLKPVSSEITYGCERIAMYLQGVDNVYDLEWIKGVSYGDIHHRSEVEFSTYNFEEADVAMLLQLFTMYEKECVRLVERGLVLPAYDFVMKCSHTFNLLDARGAISVTERASYIGRVRNVARLCAEGYLKLRESLGFPLLKGGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RG5</accession>
    <name>SYGB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="1">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glycyl-tRNA synthetase beta subunit</fullName>
            <shortName evidence="1">GlyRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glyS</name>
        <name type="ordered locus">Gmet_2941</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)</text>
            <dbReference type="Rhea" id="RHEA:16013"/>
            <dbReference type="Rhea" id="RHEA-COMP:9664"/>
            <dbReference type="Rhea" id="RHEA-COMP:9683"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.14"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512877.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RG5"/>
    <dbReference type="SMR" id="Q39RG5"/>
    <dbReference type="STRING" id="269799.Gmet_2941"/>
    <dbReference type="PRIDE" id="Q39RG5"/>
    <dbReference type="EnsemblBacteria" id="ABB33159">
        <property type="protein sequence ID" value="ABB33159"/>
        <property type="gene ID" value="Gmet_2941"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2941"/>
    <dbReference type="eggNOG" id="COG0751">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007220_2_2_7"/>
    <dbReference type="OMA" id="LPIPKRM"/>
    <dbReference type="OrthoDB" id="213210at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006426">
        <property type="term" value="P:glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00255">
        <property type="entry name" value="Gly_tRNA_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015944">
        <property type="entry name" value="Gly-tRNA-synth_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006194">
        <property type="entry name" value="Gly-tRNA-synth_heterodimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30075">
        <property type="entry name" value="PTHR30075"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02092">
        <property type="entry name" value="tRNA_synt_2f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01045">
        <property type="entry name" value="TRNASYNTHGB"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00211">
        <property type="entry name" value="glyS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50861">
        <property type="entry name" value="AA_TRNA_LIGASE_II_GLYAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000006361" description="Glycine--tRNA ligase beta subunit">
        <location>
            <begin position="1"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00255"/>
        </source>
    </evidence>
    <sequence length="686" mass="74759" checksum="80F12E8A87A3CF78" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RL5</accession>
    <name>Q39RL5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512827.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2891"/>
    <dbReference type="EnsemblBacteria" id="ABB33109">
        <property type="protein sequence ID" value="ABB33109"/>
        <property type="gene ID" value="Gmet_2891"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2891"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_129874_0_6_7"/>
    <dbReference type="OMA" id="QIRFLYY"/>
    <dbReference type="OrthoDB" id="2023580at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16377">
        <property type="entry name" value="23S_rRNA_IVP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012657">
        <property type="entry name" value="23S_rRNA-intervening_sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036583">
        <property type="entry name" value="23S_rRNA_IVS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38471">
        <property type="entry name" value="PTHR38471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05635">
        <property type="entry name" value="23S_rRNA_IVP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158446">
        <property type="entry name" value="SSF158446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02436">
        <property type="entry name" value="TIGR02436"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="121" mass="13665" checksum="BC968F4CBA601DDE" modified="2005-11-22" version="1">MRDHKELDVWKTGVELVTSVYVATQSFPKEQLHGLTNQLRRAAVSIPSNIAEGAARQTNREFVQFLYIALGSVAEVETQLIIADKLNYIADVTSVLNRIASLRKMLHGLIRHYRTKETQGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RN9</accession>
    <name>Q39RN9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltrn_RNA_4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514598.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2867"/>
    <dbReference type="EnsemblBacteria" id="ABB33085">
        <property type="protein sequence ID" value="ABB33085"/>
        <property type="gene ID" value="Gmet_2867"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2867"/>
    <dbReference type="eggNOG" id="COG4752">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1414575_0_0_7"/>
    <dbReference type="OMA" id="GTGWGMP"/>
    <dbReference type="OrthoDB" id="1276858at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18085">
        <property type="entry name" value="TM1570-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019230">
        <property type="entry name" value="RNA_MeTrfase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09936">
        <property type="entry name" value="Methyltrn_RNA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="SSF75217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltrn_RNA_4" evidence="3">
        <location>
            <begin position="10"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="193" mass="21443" checksum="91E67E713FBA5779" modified="2005-11-22" version="1">MSGATLSNANVSVALLHHPVYDKNRQVVSTAVTNLDIHDIARSARTFGLLSYYIVTPVPGQQELAGRIVRHWQEGWGATYNPKRKAALELIKIAATLNDALEDMQERFGRPVRLVTTGARLHPRSVTFSDLQHLITERDQPYLLLFGTGWGLVEEVFEKADLVLEPIQGAGDYNHLSVRSAAAIIMDRLFGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RY2</accession>
    <name>Q39RY2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, UPF0118 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2774</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366099.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2774"/>
    <dbReference type="EnsemblBacteria" id="ABB32992">
        <property type="protein sequence ID" value="ABB32992"/>
        <property type="gene ID" value="Gmet_2774"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2774"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_8_0_7"/>
    <dbReference type="OMA" id="YLQFEAY"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="348" mass="38163" checksum="B4DB36B39293BED3" modified="2005-11-22" version="1">MGERAPAAQRGIMWFLAAAAVIAAGYAVSHTLSCFLLSFVLAYLLDPAVVLLERRGLRRSWGIVALYLVLTVLSLFFVAFIVPFASIRWEAFLKGLPAYLQKGKAIVLSWKMQALPAGADDEWRWLFETATGQIDKMAARLGAGVYEAATGFVFNLFNLVLAPILIFFMLWYKNEIKTGIITWLPRSRREAVLTLGREINASVGGYIRGQLIVSAIVAILSIIALFILGIDYPFLNGIFAGLASVLPFIGVILATLPPLFFAYVQYQSGFVLLKVIGAFAVIYFLEGYVVKPLVFKESMDLNPLVTIMVVMLFGELMGFWGILLAIPIAAAVRIVADHVRRGDLSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S24</accession>
    <name>Q39S24_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromate transport protein ChrA, subunit 1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511728.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2732"/>
    <dbReference type="EnsemblBacteria" id="ABB32950">
        <property type="protein sequence ID" value="ABB32950"/>
        <property type="gene ID" value="Gmet_2732"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2732"/>
    <dbReference type="eggNOG" id="COG2059">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018106_1_0_7"/>
    <dbReference type="OMA" id="MLGIMAY"/>
    <dbReference type="OrthoDB" id="1884249at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015109">
        <property type="term" value="F:chromate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003370">
        <property type="entry name" value="Chromate_transpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02417">
        <property type="entry name" value="Chromate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="184" mass="20117" checksum="7F1261F421D8C2BE" modified="2005-11-22" version="1">METTGNRVSLGEIFRTFLIIGVTGFGGGMAVVALVERVCVHDKEWLSHEEFMHGLAFGQFLGPFSLNSCTFVGCTLRGRIGGTVAAFAFILPSFLIVSFLSLLYFRYHELPELQSALQGTNPVIIALILVAAIGMGRKIRGVEPWAIALLTFGLAAFFQVNGLALLALTAFWSLARARFRQVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S94</accession>
    <name>Q39S94_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511799.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2662"/>
    <dbReference type="EnsemblBacteria" id="ABB32880">
        <property type="protein sequence ID" value="ABB32880"/>
        <property type="gene ID" value="Gmet_2662"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2662"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_7_1_7"/>
    <dbReference type="OMA" id="QNNYGST"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223470" evidence="2">
        <location>
            <begin position="23"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="64"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="172"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="335"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="367"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="400"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="433"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="486"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="519"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="555"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="756" mass="81066" checksum="294433392E424D28" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SD3</accession>
    <name>Q39SD3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioredoxin-like_fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32841.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2622"/>
    <dbReference type="KEGG" id="gme:Gmet_2622"/>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_124905_0_0_7"/>
    <dbReference type="OMA" id="GCKQMEE"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0711">Selenium</keyword>
    <keyword evidence="2" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="1">
        <location>
            <begin position="19"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32841.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="190" mass="21322" checksum="54DF6690E5A1BF52" modified="2012-10-31" version="2">MAQIEWITSLAEGLSMAGRENRLVLLDFFNPGUIGCKQMDAVAYPDAAVMTFINDNLVPVRIPADDPVLGPQFKVKWTPTIIVLDAQGDEHYRTLGFYPPADLIPSLLLGMGKARFNQPDRQAACQCFRRIISDYPKNSLAPEAIYLNGVARYIETHDVANLIGIHDRLAAEYPDSPWLTRADPYKLLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SK6</accession>
    <name>Q39SK6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP--methionine S-adenosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">metK-2</name>
        <name evidence="2" type="ordered locus">Gmet_2549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AdoMet synthetase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513485.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2549"/>
    <dbReference type="EnsemblBacteria" id="ABB32768">
        <property type="protein sequence ID" value="ABB32768"/>
        <property type="gene ID" value="Gmet_2549"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2549"/>
    <dbReference type="eggNOG" id="COG1812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057642_0_0_7"/>
    <dbReference type="OMA" id="IGHPDSI"/>
    <dbReference type="OrthoDB" id="468241at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042543">
        <property type="entry name" value="AdoMet_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027790">
        <property type="entry name" value="AdoMet_synthase_2_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042544">
        <property type="entry name" value="AdoMet_synthase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36697">
        <property type="entry name" value="PTHR36697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01941">
        <property type="entry name" value="AdoMet_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="400" mass="43525" checksum="9CB7C8B74C1CE488" modified="2005-11-22" version="1">MITIEAFKGNSVQEQQVEIVERKGKGHPDFICDAAMDAVSVALSQEYIRQFGRILHHNIDKSLLAAGSVEKRFGGGRVIRPMELIIGDRATFSVGDRQIPVTEIALGAAREWFRKNLRFVDPELHVNFRVVLAPGSEELTDIFARPGEVMAANDTSAAVGYWPLSPTELAVLALEQHLNSREFKEHFPETGEDIKVMGLRSGKDLELTVAMPFLARFIESEGEYFARKGVVEREIGEFLTGLPGFGRKGVRLNALDEPGRGLGGVYLSLLGTSAEDADSGQVGRGNRVNGIIALGRPLGTEAAAGKNPVSHVGKIYNILAHRLAQEICEELEGVREAHVLLLSRIGTPIDRPRMAAAQLLLEKGIRLGNVSAKAEEIIGQRLAGINGFCMELAAGRYPVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SL9</accession>
    <name>Q39SL9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514518.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2534"/>
    <dbReference type="EnsemblBacteria" id="ABB32755">
        <property type="protein sequence ID" value="ABB32755"/>
        <property type="gene ID" value="Gmet_2534"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2534"/>
    <dbReference type="eggNOG" id="COG3636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_137365_1_1_7"/>
    <dbReference type="OMA" id="NMSQIAR"/>
    <dbReference type="OrthoDB" id="2002329at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014057">
        <property type="entry name" value="HI1420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40275">
        <property type="entry name" value="PTHR40275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02684">
        <property type="entry name" value="dnstrm_HI1420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="52"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="98" mass="10480" checksum="8FAB366DE7C5D834" modified="2005-11-22" version="1">MTKTATSRYDVAEHLRTPEEMAAYLEASFEEANGDAAFIAKALGDIARAKGMSQVARDAGLSRESLYKALSGERVPGFDTILKIVSALGLKLHAEAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SR6</accession>
    <name>Q39SR6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dmu-9_3-mt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512416.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2483"/>
    <dbReference type="EnsemblBacteria" id="ABB32708">
        <property type="protein sequence ID" value="ABB32708"/>
        <property type="gene ID" value="Gmet_2483"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2483"/>
    <dbReference type="eggNOG" id="COG3865">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_22_0_7"/>
    <dbReference type="OMA" id="DQDEVDY"/>
    <dbReference type="OrthoDB" id="1889762at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06588">
        <property type="entry name" value="PhnB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009725">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028973">
        <property type="entry name" value="PhnB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06983">
        <property type="entry name" value="3-dmu-9_3-mt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF021700">
        <property type="entry name" value="3_dmu_93_MTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dmu-9_3-mt" evidence="1">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="161" mass="17490" checksum="34CA6E2C79BF69A8" modified="2005-11-22" version="1">MDKPAKNTICLWYDGDAEDAAWFYAQTFPDSSVGAVYRAPGDFPSGKKGDVLTVEFTVMGIPCLGLNGGPEVKHNEAFSFQVATVDQAETDRYWNAIVGNGGQESVCGWCKDKWGVSWQITPIALTKAVTDPDTATAKRAFDAMMQMKKIDIAAIEAARRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T00</accession>
    <name>Q39T00_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoside triphosphate pyrophosphohydrolase MazG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mazG</name>
        <name evidence="2" type="ordered locus">Gmet_2399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512501.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2399"/>
    <dbReference type="EnsemblBacteria" id="ABB32624">
        <property type="protein sequence ID" value="ABB32624"/>
        <property type="gene ID" value="Gmet_2399"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2399"/>
    <dbReference type="eggNOG" id="COG3956">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038356_0_1_7"/>
    <dbReference type="OMA" id="HPHIYGD"/>
    <dbReference type="OrthoDB" id="1099129at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004518">
        <property type="entry name" value="MazG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011551">
        <property type="entry name" value="NTP_PyrPHydrolase_MazG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30522">
        <property type="entry name" value="PTHR30522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03819">
        <property type="entry name" value="MazG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00444">
        <property type="entry name" value="mazG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="30"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="MazG" evidence="1">
        <location>
            <begin position="168"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="264" mass="29959" checksum="787EAEF5C4C3537A" modified="2005-11-22" version="1">MKNEGAGFERIMEIMRRLRGPGGCPWDAEQTHESLKRYLLEEAYEVIEAIDAGSAAMLREELGDLLLQPVFHAVVAEERGAFSMAEVLETLAEKLVNRHPHVFGDQVIKTSQEQLENWERLKQQEKKEERKSALSGVPPHLPALMKAQKVTEKAARVGFDWSHVDEVFAKVMEELHEFEETMLAGDQERMEAELGDLLFAIVNLGRFLAIDPEEALRKTITRFTGRFGHIEETLHGRGVSLKDASLAEMEALWKEAKRMEHGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T30</accession>
    <name>Q39T30_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Diacylglycerol kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Gmet_2369</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial diacylglycerol kinase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513251.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2369"/>
    <dbReference type="EnsemblBacteria" id="ABB32594">
        <property type="protein sequence ID" value="ABB32594"/>
        <property type="gene ID" value="Gmet_2369"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2369"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0818">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101368_0_0_7"/>
    <dbReference type="OMA" id="KFMQGGM"/>
    <dbReference type="OrthoDB" id="1893988at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000829">
        <property type="entry name" value="DAGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036945">
        <property type="entry name" value="DAGK_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34299">
        <property type="entry name" value="PTHR34299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01219">
        <property type="entry name" value="DAGK_prokar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01069">
        <property type="entry name" value="DAGK_PROKAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="13">
        <location>
            <begin position="123"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="261" mass="27771" checksum="15CA4C24D731E59D" modified="2005-11-22" version="1">MSSPYGDTDAEGSPLRPSPTLPNGDPVKPSRFIDSVNCAIEGIFWATRTQKHMRRHFLSALVLLFAVLFLRVSALEFTLLAVSVSFVLFAELMNTAVEVVVDMVSPEYHPLARIAKDVAAGGVLVAAIGAAVMGYLILSHYIFPIYKEALAMIGTPSEMGAVVALLAVVIVVVILKSISGKGTPLEGGLPSGHAAVAFSIATLVTLNTQDPLTSILAIILAVMVSHSRLLLNIHTMREVVFGAATGTGITLLVLMLFRFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T56</accession>
    <name>Q39T56_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2343</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513277.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2343"/>
    <dbReference type="EnsemblBacteria" id="ABB32568">
        <property type="protein sequence ID" value="ABB32568"/>
        <property type="gene ID" value="Gmet_2343"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2343"/>
    <dbReference type="eggNOG" id="ENOG5032IIJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_896471_0_0_7"/>
    <dbReference type="OMA" id="MAFMISE"/>
    <dbReference type="OrthoDB" id="956893at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="309" mass="34473" checksum="9F8379F3A4A32EC6" modified="2005-11-22" version="1">MPKLYINEFVGISNRLETLPLAFAIRQAYGHDIILDWHELDSFSVEGTRRGKVRALTKLGAVRVRNCDEEMFGRLAGRKIILRSLDGPSELLDPIYLDVARKVRLNPSLATQIRSFFGRTSGRPVVGVHIRHGDFQVVDPDRYENTATEWPAVPLWWYERAMAAIQARQKDTVFFLAGTGDPDTYTELHRNFDVATLDVVSHYDYKGPDHDSRVNPVADLFALACCPLMLATPISGYSHWAANALGGPTDCIVPLPGATRDEPFMGVLRIYGSRLPRWRAAGRTGSDVVPIDQRLEGVDLGRGADTGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T65</accession>
    <name>Q39T65_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Galactosyltransferase/glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2334"/>
    <dbReference type="CAZy" id="GT8">
        <property type="family name" value="Glycosyltransferase Family 8"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32559">
        <property type="protein sequence ID" value="ABB32559"/>
        <property type="gene ID" value="Gmet_2334"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2334"/>
    <dbReference type="eggNOG" id="COG1442">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050833_0_0_7"/>
    <dbReference type="OMA" id="IWSDVDV"/>
    <dbReference type="OrthoDB" id="842233at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="317" mass="37367" checksum="E0AEBDB9C14360C7" modified="2005-11-22" version="1">MLVAINELNIPVFFAFDNNYVIPAAVAFHSLLANVNVSYKYHFIVLHEDISEENRDLLAQVVSLFSNASVEFRDMGESFKNEWENIKGKGHYTKECLYKLVPMLEFPQYDKIIWSDVDVVFKDDISDVFFMLSEENYIAGVRVCGKLDKYYENMNMPAEIKSILKNGIGAGILVYNLKKMREDNIYDDIMIALQGMSSIVVQPEQDILNIVLKDKIDYIPLRYCFCTYMYNLFKDRHKMKLKVKGNLFNYLFKGYRKNLGFDTIYSEKELLEAFESPAIIHYATSTKPWNTLFTKRKSDWLYCLLKTPFWKRYIFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TA0</accession>
    <name>Q39TA0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipopolysaccharide biogenesis outer membrane chaperone lipoprotein LptE, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">lptE</name>
        <name evidence="3" type="ordered locus">Gmet_2299</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514499.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2299"/>
    <dbReference type="EnsemblBacteria" id="ABB32524">
        <property type="protein sequence ID" value="ABB32524"/>
        <property type="gene ID" value="Gmet_2299"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2299"/>
    <dbReference type="eggNOG" id="COG2980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_114082_0_3_7"/>
    <dbReference type="OMA" id="QQVYPVN"/>
    <dbReference type="OrthoDB" id="1788185at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007485">
        <property type="entry name" value="LPS_assembly_LptE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04390">
        <property type="entry name" value="LptE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="175" mass="19288" checksum="787B5136378D9B66" modified="2005-11-22" version="1">MSTLKGSIVRLVVAIVTMLVIAGCGYHIMRPARGGAELEGKTLQVSIFTNRSFRPNIEATLTDIIVDELAKREGTRLVERGGDLVLSGTVLTYGTSHASYTAKDEVKEYRATVTAEVALRRNDTGQVVWKGVITSTQDFPALTDLVVQQNSEDAAIREICRKMAREVYIHLTEDF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TA3</accession>
    <name>MIAB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase</fullName>
            <ecNumber evidence="1">2.8.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">(Dimethylallyl)adenosine tRNA methylthiotransferase MiaB</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">tRNA-i(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaB</name>
        <name type="ordered locus">Gmet_2296</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[sulfur carrier]-SH + AH2 + N(6)-dimethylallyladenosine(37) in tRNA + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-dimethylallyladenosine(37) in tRNA + 5'-deoxyadenosine + [sulfur carrier]-H + A + 2 H(+) + L-methionine + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:37067"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="Rhea" id="RHEA-COMP:10376"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="ChEBI" id="CHEBI:74417"/>
            <dbReference type="EC" id="2.8.4.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="1">Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylthiotransferase family. MiaB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514502.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39TA3"/>
    <dbReference type="SMR" id="Q39TA3"/>
    <dbReference type="STRING" id="269799.Gmet_2296"/>
    <dbReference type="EnsemblBacteria" id="ABB32521">
        <property type="protein sequence ID" value="ABB32521"/>
        <property type="gene ID" value="Gmet_2296"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2296"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_2_0_7"/>
    <dbReference type="OMA" id="CEHFHIP"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01864">
        <property type="entry name" value="tRNA_metthiotr_MiaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006463">
        <property type="entry name" value="MiaB_methiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00273">
        <property type="entry name" value="(dimethylallyl)adenosine_tRNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000374319" description="tRNA-2-methylthio-N(6)-dimethylallyladenosine synthase">
        <location>
            <begin position="1"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="2">
        <location>
            <begin position="144"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="1">
        <location>
            <begin position="377"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01266"/>
        </source>
    </evidence>
    <sequence length="441" mass="48771" checksum="48B6635BEF599098" modified="2005-11-22" version="1">MTGEKLLYIETFGCQMNVSDSEKVASLLRGEGYSQTPDSSEADLIIVNTCSVRAKAEHKVYSYLGRFRKLKRDRRLLLGVGGCVAQQEGERLLKRVPWLDLVFGTHNLHLLPEMVRAAEQGERRAAVDFIDNEARLDLFPQADEGGGVTRFVTVMQGCDNFCSYCIVPYVRGREISRRSVEIIGEIRSAVAGGVREVTLLGQNVNSYGLKTPGELSFAGLLREISAIDGLERIRFTTSHPKDISPELIACFAELPKLCGHIHLPAQAGSDSILARMNRGYTRQEYLEKVAALRAARPEILITGDIIVGFPGETEADFLQTLSLMEEVRYTDIFSFAYSPRPETAAASLGDRIMRKETTERLERVQGLQRDMTIERHAGFVGTCQAVLVEGMSKRGDQLYGRTDGNLIVNFAGNPSLAGSLVDVRITRGYPNSLLGELAVFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TD2</accession>
    <name>Q39TD2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">etfB-8</name>
        <name evidence="4" type="ordered locus">Gmet_2266</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366022.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2266"/>
    <dbReference type="EnsemblBacteria" id="ABB32492">
        <property type="protein sequence ID" value="ABB32492"/>
        <property type="gene ID" value="Gmet_2266"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2266"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_1_1_7"/>
    <dbReference type="OMA" id="GIDSKMN"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="24"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="27751" checksum="FA1383D02E2A56DC" modified="2005-11-22" version="1">MEILVCVTRVPDTAENEIEVNADGSDIERDSLVYSVNEWDNYAVEEAIRIKESSGGSVTVVTVGDGESEEVLRREMAMGADRGILLQDESFAGTDGRGLATILKAEIEKGKYDLILAGAQADAGAGEVGGMLAALLDFPYASLVNSIEIVDDKTLKVGREVDGGNIEMNRISLPCVLSIQTGINEPRYVGIRGIRQVASVQIPVHGAGELGLSTAAVEPRVRREDYFVPELGAGAEMLDGSNEEIIDKLVEMLKAKGGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TD6</accession>
    <name>Q39TD6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">etfA-6</name>
        <name evidence="7" type="ordered locus">Gmet_2262</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366018.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2262"/>
    <dbReference type="EnsemblBacteria" id="ABB32488">
        <property type="protein sequence ID" value="ABB32488"/>
        <property type="gene ID" value="Gmet_2262"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2262"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_7"/>
    <dbReference type="OMA" id="FEVGCCN"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="6">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="301" mass="31581" checksum="EFA5D7EB155F42BD" modified="2005-11-22" version="1">MKTLLIGEYREGKLLDSTYELLGFAQQLEAQSAMLVVGSESQLPAYGGTLYLADAASCGEYNPDLHKQLILDAIEKENPDYVVFIHSSYGWDLAPRVAARLKVAQVSEVIGLTDGGFEVGCCNAKMRRTVKPATGKAVITIQAGAFAAIQPGGTPSVQKITASVTSNVSFAGYEPAEAKDVDLTRAEVIVTAGRGIGKKENVEVIAALAKALGGELGASRPVVDAGWVEHSHQVGTTGQTVSPKLYIACGVSGAIQHLAGMKKSDFIVAINKDKDAPIGEVADVLVVADILQFVPALTAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TK4</accession>
    <name>Q39TK4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NADH-dependent flavin oxidoreductase, Oye family, and FAD-dependent pyridine nucleotide-disulfide oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2193</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365949.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2193"/>
    <dbReference type="EnsemblBacteria" id="ABB32420">
        <property type="protein sequence ID" value="ABB32420"/>
        <property type="gene ID" value="Gmet_2193"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2193"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012153_1_2_7"/>
    <dbReference type="OMA" id="NQACIAY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_FMN" evidence="2">
        <location>
            <begin position="12"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="386"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="645" mass="69751" checksum="3D7735E88113F068" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TL8</accession>
    <name>Q39TL8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2177</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2177"/>
    <dbReference type="EnsemblBacteria" id="ABB32406">
        <property type="protein sequence ID" value="ABB32406"/>
        <property type="gene ID" value="Gmet_2177"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2177"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068669_0_0_7"/>
    <dbReference type="OMA" id="DYISHTD"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="345" mass="38879" checksum="911BC5B5515A9D27" modified="2005-11-22" version="1">MDNIRITTEPRRDCLLCGRNGNALYEDLGDRLFGAPGKWTLEKCVNDNCGLVWLNPAPRKDEIWKAYASYYTHGDNQAPPAGVAKRIFHCVRDCYLALKYDYFNELRQSPLRFLGTLLYLFPGRRADVDFSVMYLRSRPGGRLLEIGCGSGTMLSYLGSLGWRTEGIDVDPSAVANARSKGLNVAQGDLLEQPYGDNTFDAVMISHVIEHVPNPVELLTECYRILKPGGVLSLVTPNVESMGSHLFGRHWLHLDPPRHLILYNVRTIRALARKAGFTNMEIRTTIRDAHALFWASYSISRRGTYAMGSQPGRSGRLFMLLMRLVEWGLLKVFPHKGEELSLMGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TP2</accession>
    <name>Q39TP2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2153</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513052.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2153"/>
    <dbReference type="EnsemblBacteria" id="ABB32382">
        <property type="protein sequence ID" value="ABB32382"/>
        <property type="gene ID" value="Gmet_2153"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2153"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_1_0_7"/>
    <dbReference type="OMA" id="YYVYDAE"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="258" mass="27700" checksum="39A46C5C281A9E34" modified="2005-11-22" version="1">MKVLVCIKQVPDMESRFKANSSGNWYDEADLAFRMNEYDEYAVEQAVQLREQLGDAADVTVLSIGPDRVVEALKKALAMGCDRGVHVQDPAVSLKDPWQIASIIATYAKDKGFDLIFTGMQSQDRGSAQVGVAVAEQLGYSCATTLVGFSFADGVVTAKRELEGGLKGVVKLKTPALVTCQLGLNVPRYPTLPNIMKAKKKEIAAIPGVDVLKEEALAATASVYPPARKGGGIVLEGDLNEMADKLLGILKEKTAVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TT9</accession>
    <name>Q39TT9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable butyrate kinase</fullName>
            <shortName evidence="8">BK</shortName>
            <ecNumber evidence="8">2.7.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Branched-chain carboxylic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">buk</name>
        <name evidence="10" type="synonym">buk-1</name>
        <name evidence="10" type="ordered locus">Gmet_2106</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + butanoate = ADP + butanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:13585"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58079"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.7" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513098.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2106"/>
    <dbReference type="EnsemblBacteria" id="ABB32335">
        <property type="protein sequence ID" value="ABB32335"/>
        <property type="gene ID" value="Gmet_2106"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2106"/>
    <dbReference type="eggNOG" id="COG3426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048716_0_0_7"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047761">
        <property type="term" value="F:butyrate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00542">
        <property type="entry name" value="Butyrate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011245">
        <property type="entry name" value="Butyrate_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF3">
        <property type="entry name" value="PTHR21060:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036458">
        <property type="entry name" value="Butyrate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02707">
        <property type="entry name" value="butyr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="359" mass="38571" checksum="4A46D80140C42B6D" modified="2005-11-22" version="1">MNRDKTILIINPGSTSTKIGIFSAGEMKINVSVRHDDAELRKFATIWDQYDYRKDALLGFLRDHDLAMDDIDAIACRGGNVRPLPGGIYRLCPRMIADMKSGIYGGHPINVGGLVAYDLGNQYGIPVLTADPPMTDELCASARYSGIPQLTRTSSFHALNQKATARRIAAELGKRYDEVNLIVAHLGGGISVGAHQKGKIVDVNNALDGDGPFSPERAGTLPAGDLVKLCFSGDYTKAEVLKLLTGGGGLYAYLGTTNVIEIEKRITAGDGKAAEVFEAMIYQVAKEIGACAAVLEGTVDAIALTGSLVYSERLLESLKRKIAFIAPVHLNPGENEMEALADAAMRYFSQEEELSVYAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U05</accession>
    <name>Q39U05_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoacid dehydrogenase acyltransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512911.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2040"/>
    <dbReference type="EnsemblBacteria" id="ABB32269">
        <property type="protein sequence ID" value="ABB32269"/>
        <property type="gene ID" value="Gmet_2040"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2040"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1004099_0_0_7"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="2-oxoacid_dh" evidence="1">
        <location>
            <begin position="29"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="2-oxoacid_dh" evidence="1">
        <location>
            <begin position="209"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="267" mass="30615" checksum="62B94AAA87181EFB" modified="2005-11-22" version="1">MNTSENKFSILSSNRIVKAFWTLNDEMKPAYKVTFVREIDASAMDRLRQNILRQTSVKPSYTAFVIKAAAMALQEHPYANRALLGFSFWKRFVQFNRFDITVAVERNVPNAESVVLAATILECDKKSLADLTCELVELSNATEDSNPRWRLFYSLLSKVPVFFSKWLIRLPRLFPSMWATHRGGACFVNSPAKYGIDFFIGDMLWPLTVTFGWVKERPIAIDGRVEARRTVPLGLIFDRRIMAGAPAARFFTRIAYILEHADEEIIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U15</accession>
    <name>Q39U15_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Periplasmic polysaccharide biosynthesis/export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512920.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2030"/>
    <dbReference type="EnsemblBacteria" id="ABB32259">
        <property type="protein sequence ID" value="ABB32259"/>
        <property type="gene ID" value="Gmet_2030"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2030"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038343_0_2_7"/>
    <dbReference type="OMA" id="VREITNS"/>
    <dbReference type="OrthoDB" id="687725at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223269" evidence="2">
        <location>
            <begin position="32"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="3">
        <location>
            <begin position="197"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="282" mass="30670" checksum="A14B39CA06B3820B" modified="2005-11-22" version="1">MERLQRMLKFSCGFIAVVLVVTMLSGTSAMASEGSDGDYVVGDGDSLMISVWGEKELSGTVTVRPDGKITLPAIGDVIASGFTPTKLSEDLAEKLAKVVNKPIVTVTVNTVTNNKIYVFGGGVPSGVAVLPSRTTLLQFLIRYGNFKGIDLGNAYLLRNGKKMDVDFHSLLVKGDVAKDVPLKPEDMIYIPDNEAYKIYVMGAVANPKYVFYRDGLRILDAIIETGGFTKFAKENDVLIVRKEGTSTTEISAKVKDLMKEGDMTQNVHLKPGDFVIVKESIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U20</accession>
    <name>Q39U20_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formyl_trans_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512925.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2025"/>
    <dbReference type="EnsemblBacteria" id="ABB32254">
        <property type="protein sequence ID" value="ABB32254"/>
        <property type="gene ID" value="Gmet_2025"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2025"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088237_1_0_7"/>
    <dbReference type="OMA" id="FITQDDP"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001555">
        <property type="entry name" value="GART_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00373">
        <property type="entry name" value="GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="1">
        <location>
            <begin position="100"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="270" mass="30612" checksum="530C4132277256C6" modified="2005-11-22" version="1">MPMSDTKSKKLNVLFITQDDPFYVRLFFEEFFKSFNDLASIKGVVIAAAMGKKGPVQLARQMYDFYGPLDFVRVGTRYASYKVKARIPALAGGNFYSVGQLCAHHGMPVFSTNRVNSPEFLASLREMDLDLIASVAAPVIFKKELVELPRLGCINIHNGALPRYRGMLPNFWQMYHNERQVGITIHEMNEKLDDGRILRQEMVDILPGETLDSLIRRTKILGAHVMARAIASLRDGTATYRENPASEGSYFSFPTKDHVREFKQNGKRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U22</accession>
    <name>Q39U22_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512927.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2023"/>
    <dbReference type="EnsemblBacteria" id="ABB32252">
        <property type="protein sequence ID" value="ABB32252"/>
        <property type="gene ID" value="Gmet_2023"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2023"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030024_5_3_7"/>
    <dbReference type="OMA" id="MSFQSHT"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="69"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="275" mass="30078" checksum="7C46285752728794" modified="2005-11-22" version="1">MDTIPAMTAPVLMYHEVTATSEQDKAVRKTNPAYCVTADAFRSQMEQLTAGGFRSLSLDDLLTGNGERNGVVITFDDGWDNNHSAAWPILTGLGLTATIFVVSCFMGQPGYMTWEQVRELADAGISIQSHTVSHRPLGLLTDGEIRAELEDSKKAIEDRIGRAVNHISMPQGVFDRRVIEMAAQAGYRSVSTSEPVIRHRGGTPAVLGRINVSGSYDLATFGRIVAGDRSVLLPMIINKKAKNFVKSLVGYGTYRKLYRFCYRIDDSGTGNISNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UA2</accession>
    <name>Q39UA2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Adenylosuccinate lyase</fullName>
            <shortName evidence="11">ASL</shortName>
            <ecNumber evidence="4 11">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">purB</name>
        <name evidence="13" type="ordered locus">Gmet_1943</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:23921"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = AMP + fumarate</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:16854"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="4 11"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511900.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1943"/>
    <dbReference type="EnsemblBacteria" id="ABB32172">
        <property type="protein sequence ID" value="ABB32172"/>
        <property type="gene ID" value="Gmet_1943"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1943"/>
    <dbReference type="eggNOG" id="COG0015">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030949_0_1_7"/>
    <dbReference type="OMA" id="ASSCEKI"/>
    <dbReference type="OrthoDB" id="347727at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="SSF48557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 11" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADSL_C" evidence="12">
        <location>
            <begin position="349"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="431" mass="49350" checksum="9A545B5C4B9A702F" modified="2005-11-22" version="1">MIERYSRPEMTRIWEARNRYQKWLDIEIFACEAHAELGNIPREAVERIKAKADFDVERIDEIERTVKHDVIAFLTSVADYIGDDSRFVHLGLTSSDVLDTSFAMLLAEASDLIIDDIKRLMEVIKRRAFEHRDTPMMGRSHGIHAEPVTFGIKMALWYDEMRRNLRRMESARETIAYGKISGAVGTFANIDPRVEEYVCKKGGLKPAPCSTQVIQRDRHAEFFSALAIIASSIEKFAVEIRHLQRTEVLEAEEYFSKGQKGSSAMPHKRNPVLSENLTGLARLIRGYAVSAMENVPLWHERDISHSSVERVIGPDATIVMDFMLNRCIGLIDNLVVYPENMMRNLNLMRGLIFSQRVLLKLANAGASREKAYELVQRNAMKVWEQGKDFQEELLADADVRGFLPEEEIREAFDLNYHLKHVGTIFTRVFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UB4</accession>
    <name>Q39UB4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Winged helix-turn-helix transcriptional regulator, Rrf2 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1931</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511912.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1931"/>
    <dbReference type="EnsemblBacteria" id="ABB32160">
        <property type="protein sequence ID" value="ABB32160"/>
        <property type="gene ID" value="Gmet_1931"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1931"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_1_3_7"/>
    <dbReference type="OMA" id="FSKTCEY"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="135" mass="14622" checksum="EE44DAE29E4B8CFC" modified="2005-11-22" version="1">MMELTRKGEYAIRGIIHLAQLPPGKVALISEIAEATDVPQTFLAKILQSFAKIGIVQSFRGAGGGFMLGRSASRITLREVVEAVEGPILPNRCLIGSGTCERDSTCGVHPVWRQVQQRVVEVLDGVTIEDLATHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UB5</accession>
    <name>Q39UB5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Cytochrome bd menaquinol oxidase, subunit I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cydA</name>
        <name evidence="13" type="ordered locus">Gmet_1930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the cytochrome ubiquinol oxidase subunit 1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511913.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1930"/>
    <dbReference type="EnsemblBacteria" id="ABB32159">
        <property type="protein sequence ID" value="ABB32159"/>
        <property type="gene ID" value="Gmet_1930"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1930"/>
    <dbReference type="eggNOG" id="COG1271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030555_3_1_7"/>
    <dbReference type="OMA" id="FLINIAM"/>
    <dbReference type="OrthoDB" id="271551at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070069">
        <property type="term" value="C:cytochrome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002585">
        <property type="entry name" value="Cyt-d_ubiquinol_oxidase_su_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30365">
        <property type="entry name" value="PTHR30365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01654">
        <property type="entry name" value="Cyt_bd_oxida_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006446">
        <property type="entry name" value="Cyt_quinol_oxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 12" id="KW-0349">Heme</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="404"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="450" mass="49973" checksum="0E04161ABAE3BC3A" modified="2005-11-22" version="1">MDVLTLSRLQFAATTMFHFIFVPLTLGLSILTAYMETRYVRTGDETYLKMTKFWGKLFLINFALGVVTGITQEFQFGMNWAEYSRYVGDIFGAPLAIEATVAFFLESVFIGVWIFGWNKISKTAHAVSIWLVAIATNLSALWILLANGWMQKPVGYVLRNGRAEMVDIIAVITNPYGLIKFVHTVGSGYMVAAFFVMGISAWHLLRKSRVDFFVRSFKMGSVFSLVSALLVFGSGDFHAVEIAKTQPTKFAAMESVWETQKGAGMNLFLLPDPENECNAIERLCIPNMVSMLAFHDPTAEIKGLKDFPKELRPPVQPTFWSFRLMVGMGTFTALVSLAAVILSRMKNLENKTLFLRLMVLALPLPYIAAQLGWVVAEMGRQPWIVYGVLKTSDAVSKAVTSPQVIGSLVGFTLLYGLLGAIDIYLLAKYARKGPDDDLSGIIKPATVREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UB6</accession>
    <name>Q39UB6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome bd menaquinol oxidase, subunit II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cydB</name>
        <name evidence="8" type="ordered locus">Gmet_1929</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome ubiquinol oxidase subunit 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511914.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1929"/>
    <dbReference type="EnsemblBacteria" id="ABB32158">
        <property type="protein sequence ID" value="ABB32158"/>
        <property type="gene ID" value="Gmet_1929"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1929"/>
    <dbReference type="eggNOG" id="COG1294">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049294_0_1_7"/>
    <dbReference type="OMA" id="FLWGVAF"/>
    <dbReference type="OrthoDB" id="761975at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003317">
        <property type="entry name" value="Cyt-d_oxidase_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43141">
        <property type="entry name" value="PTHR43141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02322">
        <property type="entry name" value="Cyt_bd_oxida_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000267">
        <property type="entry name" value="Cyt_oxidse_sub2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00203">
        <property type="entry name" value="cydB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="342" mass="37452" checksum="7EFA07948170DC7F" modified="2005-11-22" version="1">MELQIIWFVLWGVLWAVYFMLDGFVFGTGILHNVLPRTDGEKRVLINTIGPVWDGNEVWLITAGGATFAAFPTTYALMFSYLYTALLLLLFSLIVRGVSFEFRGKLEGEGWKKAWDVAIQVSSFLPALLFGVAFGNIFKGLPMDAAGYQGSFLSLLNPYGLLTGVLFVLLFTVHGALWLSVKTVGDLRARAKGVADKTWPALLVVAVAFLAYTKFATKLFDNYLAHPLLFVVPLVAVAALIGMRLFSARGAMLTAFASSCVTVLAVVATGVAGLFPNLIPSSLDPAYSLTIFNSSSSPYTLKIMTVVAFIFVPIVIAYKIWVYRIFRAPVTEAEVLEDKHAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UM5</accession>
    <name>Q39UM5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livG</name>
        <name evidence="5" type="ordered locus">Gmet_1820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512025.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1820"/>
    <dbReference type="EnsemblBacteria" id="ABB32049">
        <property type="protein sequence ID" value="ABB32049"/>
        <property type="gene ID" value="Gmet_1820"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1820"/>
    <dbReference type="eggNOG" id="COG0411">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="FGNFLAM"/>
    <dbReference type="OrthoDB" id="1179151at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032823">
        <property type="entry name" value="BCA_ABC_TP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12399">
        <property type="entry name" value="BCA_ABC_TP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="250" mass="27304" checksum="9BEF94EAAD12B8B9" modified="2005-11-22" version="1">MLEVQGITQRFGGVTALEDVSFRVADGAITGIIGPNGAGKTTLFNIVTGIYTPTCGTVHLQGKNVTRFTPERLASLGMVRTFQNIELFGRMTVLENVMVGLHTKGKSGIIASSLRLPWQVAEERRFRERALHWLEFTGITDLADHEAGSLPFGKGRLLEIARAMALEPKVILMDEPAAGLNSRETLELARLIQKIRESGVTVALVEHDMELVMDICDAIVVLNLGRKLAQGTPREIQENPEVISAYLGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UN6</accession>
    <name>Q39UN6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Menaquinol oxidoreductase complex ACIII, cytochrome c subunit ActA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">actA</name>
        <name evidence="3" type="ordered locus">Gmet_1809</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512037.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1809"/>
    <dbReference type="EnsemblBacteria" id="ABB32038">
        <property type="protein sequence ID" value="ABB32038"/>
        <property type="gene ID" value="Gmet_1809"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1809"/>
    <dbReference type="eggNOG" id="COG3474">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077373_0_0_7"/>
    <dbReference type="OMA" id="MKMDDCA"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039118">
        <property type="entry name" value="QrcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39425">
        <property type="entry name" value="PTHR39425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="115"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="171" mass="19269" checksum="3C2D2D9E7E34BC64" modified="2005-11-22" version="1">MNKVRLIIGLAIVTVAIVAASVLLYLLPLDVRDHSPVQPIAFSHKLHAGDNGIHCLFCHSYAAKSPAAGIPSMEECRACHLFISPNTPEIKKLMKYWEKREPIPWVKVYSLPDFVYFPHMMHVRAKLSCAACHGEVAAMERITRTASLKMGWCLNCHHQHKASIDCWTCHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UP5</accession>
    <name>Q39UP5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Adenylyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512047.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1800"/>
    <dbReference type="EnsemblBacteria" id="ABB32029">
        <property type="protein sequence ID" value="ABB32029"/>
        <property type="gene ID" value="Gmet_1800"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1800"/>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035301_0_0_7"/>
    <dbReference type="OMA" id="YGGGVEC"/>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="101"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="450" mass="49044" checksum="7EA2F1FB1AB90A02" modified="2005-11-22" version="1">MNRTPLEGWIRDKLLLPGTQALTRSDLEAYQVRKLREVVAYARTKSPFYRNLLAEIDGRDVKDLQAFSRLPFTTPDDVRTQGMRMLCASQDEIERVVTLQTSGTSGEAKRIFFTAEDLELTVDFFHHGMATMVAAGATVIIFLPGERPDSVGDLLARGLARLGVRPVAFGPVRDPIAARAEILRHPSPCLVGIPTQILSLARGEGGEAIPRGWVESVLLSTDYVPTAIVEELKQHWGCRVFTHYGMTETGLGGGVECEARDGYHLREADLYTEIVDPATGRPVADGEFGEVIFTTLTRSGMPLVRYRTGDMARMMPESCPCGTVLKRLGRVQGRIGATVRLRDGASIAMATLDEALLPIPGLLNFTAEIADNGGRDQLNLCLQACEGQEEQVARGAVAALVRAESSDPLFRQGGLTLGSITFDRAGWFTTGTGKRQIRDVRQENQGAVSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UT6</accession>
    <name>Q39UT6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PilZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513347.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1757"/>
    <dbReference type="DNASU" id="3741433"/>
    <dbReference type="EnsemblBacteria" id="ABB31988">
        <property type="protein sequence ID" value="ABB31988"/>
        <property type="gene ID" value="Gmet_1757"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1757"/>
    <dbReference type="eggNOG" id="ENOG5033VQF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061358_0_0_7"/>
    <dbReference type="OMA" id="EKWEVQR"/>
    <dbReference type="OrthoDB" id="1084216at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040638">
        <property type="entry name" value="PilZN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18672">
        <property type="entry name" value="DUF5634_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5634_N" evidence="4">
        <location>
            <begin position="11"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ" evidence="3">
        <location>
            <begin position="167"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="330" mass="37824" checksum="DAE2C856B0B89A21" modified="2005-11-22" version="1">MKEEFSDYQKHFATGLRVEVRFPRGQNKPFRDGAIITLQEEDLITLQISRDALPEDVRAETGTFVDIRTGKDGNAYCSRAIIVAERDGSQVTARLIGNVIPDEMREYYRIETYVPVRYQLDLDATPEQLQERWRAKRYPVHQSTDDAAHLSTDRETSPATEPSRAVPLAANLSGSGIRIRTRDKFQTGTLLSMELYLPLEDLKIVPIIAEVVHVDTLRTKEGTPPLFSTALHFLCIDERDRDSVIRFISLEQLDRLRDHQGGTVSISSLEYAAYSRRKRLLRLATAACIILLFGAIAFALVYYRLNSPKGEIEQTFEQEIRKYRTLFPWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V18</accession>
    <name>Q39V18_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511389.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1675"/>
    <dbReference type="EnsemblBacteria" id="ABB31906">
        <property type="protein sequence ID" value="ABB31906"/>
        <property type="gene ID" value="Gmet_1675"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1675"/>
    <dbReference type="eggNOG" id="ENOG50330EW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_126613_1_0_7"/>
    <dbReference type="OMA" id="RDYSAGV"/>
    <dbReference type="OrthoDB" id="1874953at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021267">
        <property type="entry name" value="DUF2844"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11005">
        <property type="entry name" value="DUF2844"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="156" mass="17047" checksum="2EBC1A75B7B4A315" modified="2005-11-22" version="1">MRRIFVAMSLVTGLLTTPFMPARQSEAALGEPAASVAVDRKALSATQRAATTRKGYTVQELVTGGNTVREYIAPSGIVFAVAWNGVSHPDLTLLLGSYLTEYKQALRQAPRQRGQRRSQVKANQVVVEKWGHMRNLQGRAYVPGLVPDGVTINEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V88</accession>
    <name>Q39V88_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribose-5-phosphate isomerase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rpiB-1</name>
        <name evidence="4" type="ordered locus">Gmet_1604</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511461.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1604"/>
    <dbReference type="EnsemblBacteria" id="ABB31836">
        <property type="protein sequence ID" value="ABB31836"/>
        <property type="gene ID" value="Gmet_1604"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1604"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_1_7"/>
    <dbReference type="OMA" id="DYPPFCL"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004785">
        <property type="entry name" value="RpiB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30345">
        <property type="entry name" value="PTHR30345"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01120">
        <property type="entry name" value="rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="8"/>
        </location>
    </feature>
    <feature type="region of interest" description="D-ribulose 5-phosphate binding" evidence="3">
        <location>
            <begin position="65"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="64"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>D-ribulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="148" mass="15929" checksum="CC3BD44EAAA3B8FD" modified="2005-11-22" version="1">MILVGSDHGGLELKEAIKLLLTERGITVEDCGTDNGNSVDYPDFGIKVARKISAGEAEKGILFCGTGIGMSIVANKFPNVRAALATDPFMARMAKEHNNANILVLGGRVLDEATAREMVCVWLDATFEGGRHQGRLDKIAALEKELMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VB7</accession>
    <name>Q39VB7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511490.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1575"/>
    <dbReference type="EnsemblBacteria" id="ABB31807">
        <property type="protein sequence ID" value="ABB31807"/>
        <property type="gene ID" value="Gmet_1575"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1575"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_7"/>
    <dbReference type="OMA" id="HHVYLQL"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="262" mass="28215" checksum="F05E63F976C8483B" modified="2005-11-22" version="1">MPYKKLRIEIRNKVGYILLCSGQRFNKLSITTLREVKRAITELSHNPEAVCLVITGYPGESFAVGADISQMAEFGPADGFSFGELGQSLFEAMESCPKPVIGALNGITMGGGCDLALACDLRIASDALVIAHPGAKLGIITGFCGTQKLPRLVGRNYAREIFMTSEPYRAADALRMGLVDRVYPAGEFWERVVAFAERIAKVSPAALAMAKKAINAAEDCDLKTGCALEAASYAYLFATSTERGRMTEFLEGTTNVFGSEDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VE3</accession>
    <name>Q39VE3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metal ion efflux pump, RND family, inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1547</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511519.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1547"/>
    <dbReference type="EnsemblBacteria" id="ABB31781">
        <property type="protein sequence ID" value="ABB31781"/>
        <property type="gene ID" value="Gmet_1547"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1547"/>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_7"/>
    <dbReference type="OMA" id="NSWTYPI"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="345"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="867"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="891"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="917"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1045" mass="115118" checksum="6D83F7B9DC21BAB2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VE5</accession>
    <name>Q39VE5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Germane superfamily lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511521.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1545"/>
    <dbReference type="EnsemblBacteria" id="ABB31779">
        <property type="protein sequence ID" value="ABB31779"/>
        <property type="gene ID" value="Gmet_1545"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1545"/>
    <dbReference type="eggNOG" id="COG5401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_965622_0_0_7"/>
    <dbReference type="OMA" id="AFVIYFP"/>
    <dbReference type="OrthoDB" id="1039336at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Germane" evidence="1">
        <location>
            <begin position="89"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="301" mass="32502" checksum="F79FB5820B81F7AD" modified="2005-11-22" version="1">MGKVRIALVAILVLIALAGCSKEQKNVPGKQVRVSATGAYEKYFGPAPTTDKGTCYAFVIYFPSAKEPGKVVPFPFFTFDQSSLKKVAVERLLGGMDVGSYKGEFLQLFAPGTRILGLAEQNDAVTVNFSKEILAAKADAVVEKALLDAVALTLSQFSGVREVRMQIEGKESGTVDGKDVAMFLGHGGPLKPQESAVLHPSPPRLLSVTAMKEKGAKEVEEVNVFFDRPLEIKELNIAGGDNKRFDGEVYHSVFDMAAVLKPKAPSLFKAGMPVKVRWKVTDKVGRSAEGAGEFPLEVQEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VJ3</accession>
    <name>Q39VJ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1497</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365834.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1497"/>
    <dbReference type="EnsemblBacteria" id="ABB31731">
        <property type="protein sequence ID" value="ABB31731"/>
        <property type="gene ID" value="Gmet_1497"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1497"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_856998_0_0_7"/>
    <dbReference type="OrthoDB" id="1585038at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="73"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="328" mass="36496" checksum="18EDD59A8AB2F56D" modified="2005-11-22" version="1">MEIMDTEPNRKDIFPQYSICIRTLGTSADRFEALLKSIDGLTIPPNEIIVVLPHGYPAPPELRGNELVVYSGKGMLAQRIKGIESAGNDHVLLLDDDVEFEPETMNKLMLAMAKYGADIVYPINRTLLPTPGKAWLRLITIQAIARKNQDVFIRMLPTGGYSYLNKDPLTPLPSESCPGMLLLAKRSALLAINLDEDVWVDSSPYGFRDDAILSYKAHLAGYRIFAVPDVLTRHLCGSTRLDSMRAVYSAFSVGCNSFVFWKKYIFVRGNTAFKKLLLAALFAWSVISLGLLYMVNSVRNRNLSIVFAYVKGNLCGMTKNSKSIAMNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VJ5</accession>
    <name>Q39VJ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511572.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1495"/>
    <dbReference type="EnsemblBacteria" id="ABB31729">
        <property type="protein sequence ID" value="ABB31729"/>
        <property type="gene ID" value="Gmet_1495"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1495"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665256_0_0_7"/>
    <dbReference type="OrthoDB" id="1860872at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="213"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="413" mass="46585" checksum="3D728B556FFABE55" modified="2005-11-22" version="1">MIVSKNLLIHTFRRPDDGAFIRVKNLNTAIAEITAGHCHEVVLVSVRHFREIFKNDRNTRIFERRLILPILWTNRHLLARTWNGFSSCIAGLILATFLRPDIVVGETSASWKLAKATKFWRQRAKLIMDLHGAGPEEVLFHNPTSKLHESVYSYESRLEQEIALNADFITCQSVNMIEHLIIKYPATRARFHPFQCSVRSELFRMDLDTRSYYRQKLQLNDGETLFVYCGSVHKWQNVHYSVNVFAEYLKCSATAAKLLIMCPNPDAELCNHAYSLGLSDDDFRIIAVPHEEVPAYLNAADIGFLIRDDGVVNRVASPTKLGEYLACGLSVIVGNVANSWSSARLDSSCFCFVDLDNAAGAANTILRFVDSKSDDPMSVKQSATSLAGLSLSTTTETERLKMFMKHSVMEQIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VR7</accession>
    <name>Q39VR7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1423"/>
    <dbReference type="EnsemblBacteria" id="ABB31657">
        <property type="protein sequence ID" value="ABB31657"/>
        <property type="gene ID" value="Gmet_1423"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1423"/>
    <dbReference type="HOGENOM" id="CLU_2232696_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="105" mass="12026" checksum="5B4F5104B24E1C50" modified="2005-11-22" version="1">MPADLSHLLPTQFIKKSLQTSELHRSEHAVEGMLMDIHGWHNDEPIRDSRYLQNKKLTIGSALLFVNCKPTFVAGFGFARCVSFCYDTFPIPSTPRLYRCQNSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VU6</accession>
    <name>Q39VU6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Twitching motility pilus retraction ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pilT-4</name>
        <name evidence="4" type="ordered locus">Gmet_1394</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7 8" key="3">
        <citation type="submission" date="2019-04" db="PDB data bank">
            <title>Multiple conformations facilitate PilT function in the type IV pilus.</title>
            <authorList>
                <person name="McCallum M."/>
                <person name="Benlekbir S."/>
                <person name="Nguyen S."/>
                <person name="Tammam S."/>
                <person name="Rubinstein J.L."/>
                <person name="Burrows L.L."/>
                <person name="Howell PL."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513114.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="6OJX">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.89 A"/>
        <property type="chains" value="A/B/C=1-365"/>
    </dbReference>
    <dbReference type="PDB" id="6OJY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.30 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-365"/>
    </dbReference>
    <dbReference type="PDB" id="6OJZ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.03 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-365"/>
    </dbReference>
    <dbReference type="PDB" id="6OK2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.29 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-365"/>
    </dbReference>
    <dbReference type="PDB" id="6OKV">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="4.01 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-365"/>
    </dbReference>
    <dbReference type="PDB" id="6OLK">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.00 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-365"/>
    </dbReference>
    <dbReference type="PDB" id="6OLL">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.10 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-365"/>
    </dbReference>
    <dbReference type="PDB" id="6OLM">
        <property type="method" value="EM"/>
        <property type="resolution" value="4.40 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-365"/>
    </dbReference>
    <dbReference type="PDBsum" id="6OJX"/>
    <dbReference type="PDBsum" id="6OJY"/>
    <dbReference type="PDBsum" id="6OJZ"/>
    <dbReference type="PDBsum" id="6OK2"/>
    <dbReference type="PDBsum" id="6OKV"/>
    <dbReference type="PDBsum" id="6OLK"/>
    <dbReference type="PDBsum" id="6OLL"/>
    <dbReference type="PDBsum" id="6OLM"/>
    <dbReference type="SMR" id="Q39VU6"/>
    <dbReference type="STRING" id="269799.Gmet_1394"/>
    <dbReference type="EnsemblBacteria" id="ABB31628">
        <property type="protein sequence ID" value="ABB31628"/>
        <property type="gene ID" value="Gmet_1394"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1394"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_7"/>
    <dbReference type="OMA" id="IREDKVH"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01131">
        <property type="entry name" value="PilT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="3">
        <location>
            <begin position="194"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="6OJX"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="6OJY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="6OJZ"/>
        </source>
    </evidence>
    <sequence length="365" mass="40661" checksum="79E6EDBFEDBD7F7F" modified="2005-11-22" version="1">MANMHQLLTELVNRGGSDLHLTTNSPPQIRIDGKLLPLDMPPLNAVDTKQLCYSILTEQQKHKFEENNELDLSFGIKGLSRFRGNVFVQRGAVAGVFRVIPYKILSFEELGLPPVVRELAEKPRGLVLVTGPTGSGKSTTLAAIIDKINTDRHEHIVTVEDPIEYLHPHKSCVVNQREVGADTKSFKNALKYILRQDPDVVLVGELRDLETIEAALTLAETGHLCFATLHTNSAVQTINRIVDVFPSYQQPQVRAQLSFVLEGVLSQTLLPKASGTGRVLAIEVMVPNPAIRNLIREDKIHQIYSQMQVGQEKFGMMTMNQCLYGLLQKRHITMDVGMGRSPDPDELKQMLTSGVRPQAPRPPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VW4</accession>
    <name>Q39VW4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein CyaE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513132.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1376"/>
    <dbReference type="EnsemblBacteria" id="ABB31610">
        <property type="protein sequence ID" value="ABB31610"/>
        <property type="gene ID" value="Gmet_1376"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1376"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_10_6_7"/>
    <dbReference type="OMA" id="LDCFESK"/>
    <dbReference type="OrthoDB" id="1099555at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044179">
        <property type="term" value="P:hemolysis in another organism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028351">
        <property type="entry name" value="CyaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001892">
        <property type="entry name" value="CyaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0204">Cytolysis</keyword>
    <keyword evidence="2" id="KW-0354">Hemolysis</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223194" description="Protein CyaE" evidence="4">
        <location>
            <begin position="34"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR001892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="435" mass="48338" checksum="84C6990C3E91CAE6" modified="2005-11-22" version="1">MQNNQNAPIPQSTVPRLLAALAAVLSLAGTARAETLSLAECLRRAAAGNYDLTVTAHDTRIAAENISQAKSGFLPRLDFQGGYTAQARPQAFSFAGRETETQDATYGFFNVTATQTIYDFGHTSSRTRRASLLQEAITHSYDAREKDVFLQVVEAYYGILEAKKVLGAADEEIVQRTDHLGVAQNLYEQGVVTRNDLLQAEVKLADSRQRRLAAANFVENRWLFLNYLTGRPLPFRANLEEKDTPASLPPLETAEEKALANRPELASLTRTVEAGEAGVSEARTGFYPEIFAQGTIDYMENSKAREQAIYAATVGLRVNLFDGFATTSRYRQAVANLRKQRDSLRQAREQIRLELATSLNDARVAAERIRTVETAIKQGEENLRINRDRYQAQVGTATDVIDAQTLLTQIRTDYFRAVFDYQVAAARVRKAMGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W08</accession>
    <name>Q39W08_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1331"/>
    <dbReference type="EnsemblBacteria" id="ABB31566">
        <property type="protein sequence ID" value="ABB31566"/>
        <property type="gene ID" value="Gmet_1331"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1331"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_41_0_7"/>
    <dbReference type="OMA" id="FIWIIKE"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="359" mass="40877" checksum="24A080DA6DE567AD" modified="2005-11-22" version="1">MILISEPFIYSTKLWDSSEMKNILIITGVLPPKVCGVGDYTKNLLDTEIGKLWSPYVAESWRFRKLSFILKSIDQRKPDVIFMQYPAEGYGWSLVPHMLLIYYVFIKKIKFITVLHEYSSLSWKSRFFIRNILSKSSQLIFTTNFELNNLAKHVPGILSKANVLPILSNIPNPKEIKQISDRSIDILYFGHIRPNKGIEDFLRVICSSKIVNKNLSIKLVGQIPKGYENYIKSLQAIYPQVMNITTLNADLDLVHTMLGEAKICFLPYPDGISERRGSFLAAIQHGSVVASYVGTWTPSGLTSAFIPLERGHEAEKILYFLSNNELLTSQQLNSISYHNESGITNWNELSNAYLKISEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W83</accession>
    <name>Q39W83_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="7">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cdsA</name>
        <name evidence="9" type="ordered locus">Gmet_1255</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CDS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31491.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365793.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1255"/>
    <dbReference type="EnsemblBacteria" id="ABB31491">
        <property type="protein sequence ID" value="ABB31491"/>
        <property type="gene ID" value="Gmet_1255"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1255"/>
    <dbReference type="eggNOG" id="COG4589">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037294_3_3_7"/>
    <dbReference type="OMA" id="WEWGRLN"/>
    <dbReference type="OrthoDB" id="1533756at2"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31491.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="275" mass="29384" checksum="D65975F77393FB15" modified="2012-10-31" version="2">MKRLLTGVIALPLLILFILKASVFVFACFVGLLVLLGLGEFYRMALPKRPVVGTVASLSGMLVLPVLVSPELLLRFVPVPAGNGVLLALTLLFSAVAIFFLFSIRDIRQSAAEAGLIWLGFAYVPLLLSHLVLLRALPDGVSWVFLMLLIVMSGDTAAYYVGSTLGRRKLYPIVSPNKSIEGALGGLCGSLAGTLIAKYTFLHQLTVVDCVVTALAVGALGQVGDLFESLLKRSFGVKDSGIIIPGHGGILDRLDSILFAAPALYYYAYLVVMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W95</accession>
    <name>Q39W95_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_1243</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512126.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1243"/>
    <dbReference type="EnsemblBacteria" id="ABB31479">
        <property type="protein sequence ID" value="ABB31479"/>
        <property type="gene ID" value="Gmet_1243"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1243"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_51_7"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="10">
        <location>
            <begin position="217"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="293"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="536"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="654" mass="72732" checksum="A65339B41106BE5B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W99</accession>
    <name>Q39W99_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase DUF815, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1239</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1239"/>
    <dbReference type="DNASU" id="3738782"/>
    <dbReference type="EnsemblBacteria" id="ABB31475">
        <property type="protein sequence ID" value="ABB31475"/>
        <property type="gene ID" value="Gmet_1239"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1239"/>
    <dbReference type="eggNOG" id="COG2607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039512_0_1_7"/>
    <dbReference type="OMA" id="ESEFACI"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008533">
        <property type="entry name" value="DUF815"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05673">
        <property type="entry name" value="DUF815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF815" evidence="1">
        <location>
            <begin position="43"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="297" mass="33825" checksum="7EDD60DF9C3C25C3" modified="2005-11-22" version="1">MMNDRDERWDRIAGKLDTLLDRFDRFLDGHIPPPPPDGRLFERHLAFRWRRTGEGGAFLPVEHPHLPDLDDLMGIDLVRDELVRNTGQFVVGYPANNVLLWGERGTGKSTCVKGLLRRFSEEGLRLVEVLRDDLCTLPAIIAPLRKMPQRFILFCDDLSFGEGEGGYRELKVLLEGGIEERPSNILFYATSNRRHLLPERMEDNLGGEIHPEEAVSEKLSLADRFGLNLSFYSFDQDTYLAIVARYAEKFSLPMGGEALRREALQWAIFKGSRSGRSARQFVDDLAGRLRVALPAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WD5</accession>
    <name>Q39WD5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512168.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1202"/>
    <dbReference type="EnsemblBacteria" id="ABB31439">
        <property type="protein sequence ID" value="ABB31439"/>
        <property type="gene ID" value="Gmet_1202"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1202"/>
    <dbReference type="eggNOG" id="ENOG5032V11">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1151379_0_0_7"/>
    <dbReference type="OMA" id="RLITIEC"/>
    <dbReference type="OrthoDB" id="1900629at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="234" mass="26273" checksum="1FB55604AB76DED7" modified="2005-11-22" version="1">MDTAHLQKKTGYVVRLSEHALITLILNGLEAYSVEHERKTPHLETCGALFGYQVPLKDNRILYQIEIANVDTSAKRNKRSVTPNTNAMKLKADIMGAFWPNLEYLGDYHTHVYKSVSDVYSVELEEGDRRGDDKGFYISNGDRHWLEANAALCLSYGYRIGLVVTIAGMKRTGGVGAKPANSRSQAIEFNLGKKKVWLSAYYVYEQNGTVKYSANNDRLITIECPSLLGFRGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WG5</accession>
    <name>Q39WG5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Radical SAM domain iron-sulfur cluster-binding oxidoreductase with cobalamin-binding-like domain and TPR domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1171</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513437.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1171"/>
    <dbReference type="EnsemblBacteria" id="ABB31409">
        <property type="protein sequence ID" value="ABB31409"/>
        <property type="gene ID" value="Gmet_1171"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1171"/>
    <dbReference type="eggNOG" id="COG1032">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4783">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_483774_0_0_7"/>
    <dbReference type="OMA" id="QTIEMCD"/>
    <dbReference type="OrthoDB" id="973846at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034466">
        <property type="entry name" value="Methyltransferase_Class_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01123">
        <property type="entry name" value="methyltransferase_(Class_B)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="B12-binding" evidence="3">
        <location>
            <begin position="8"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="4">
        <location>
            <begin position="182"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="475"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="509"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="563" mass="62964" checksum="32EC166B984D6865" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WG7</accession>
    <name>Q39WG7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365778.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1169"/>
    <dbReference type="EnsemblBacteria" id="ABB31407">
        <property type="protein sequence ID" value="ABB31407"/>
        <property type="gene ID" value="Gmet_1169"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1169"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_1_1_7"/>
    <dbReference type="OMA" id="YWSSMKS"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223463" evidence="4">
        <location>
            <begin position="24"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="25"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="84"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="6">
        <location>
            <begin position="183"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="341" mass="37639" checksum="B53CEF821B96007F" modified="2005-11-22" version="1">MSLRLRLTALSVILLAFPALSHAAKTHKIRKSETVYSIAKKYHVSAKDLKSANNLTNARIKPGTVLVIPSRAAAESSADSSTPASYKVKKGDTLAKVARKTGVSVAELRRLNGIGKGRLKPGRLLALQAVESNETVTAKLSLKKPLKHLDIYDEKEYEQSLSELVELDPNRPADFTKSVKLDVDGVSELKKTAYSFIGTKYRFGGTTRRGLDCSSFVQHVFRELDVTLPRTAREQFHVGNSVAPGDLQKGDLLFFQTYARFPSHVGIYLGNNKMIHASSRDRRVVISSVDTPYYRSRFLGAKRIAEVNPDILKLDDLISGVEEEGLEEILTNDTLGVSLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WP1</accession>
    <name>Q39WP1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1093</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513749.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31333">
        <property type="protein sequence ID" value="ABB31333"/>
        <property type="gene ID" value="Gmet_1093"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1093"/>
    <dbReference type="eggNOG" id="ENOG5033W06">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_914822_0_0_7"/>
    <dbReference type="OMA" id="DEYWAKT"/>
    <dbReference type="OrthoDB" id="1526259at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223368" evidence="2">
        <location>
            <begin position="24"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="319" mass="34778" checksum="BD436034F2819FC0" modified="2005-11-22" version="1">MKTPLIALACMALVLVCSPTSRADDEVLPQPSPPLCEETLKRQDEALAALKAEQSRLEQKIRDMECAPVVSSDELLARNLHHLQSLAANTRAQRQTMTDFRTFVTWMSSSLAGYEKYIQAGSVVAGAAKVLPIPYAGQASMLTKFVSQGVLSLNAASGSIATYLKISDQYLALAGGIDPKRPDPARVSAAVRFADGEFLRSMTDVQAKLRTSADISASTLSFLKTLDSYVGGSDEYWARTKAFITRNDAYKKDKSYLASSIEGLTSQAGAFNNRLTLFEETARKDLPIIKNLVAYDELAREIDARARQKREAMAAAVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X08</accession>
    <name>Q39X08_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV pilus assembly lipoprotein PilP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilP</name>
        <name evidence="3" type="ordered locus">Gmet_0974</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365753.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0974"/>
    <dbReference type="EnsemblBacteria" id="ABB31216">
        <property type="protein sequence ID" value="ABB31216"/>
        <property type="gene ID" value="Gmet_0974"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0974"/>
    <dbReference type="eggNOG" id="COG3168">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1480042_0_0_7"/>
    <dbReference type="OMA" id="QTRCATP"/>
    <dbReference type="OrthoDB" id="1864613at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007446">
        <property type="entry name" value="PilP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04351">
        <property type="entry name" value="PilP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223374" evidence="2">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="182" mass="18985" checksum="E5D68DCE46040A22" modified="2005-11-22" version="1">MTRRNSTSMLLLAAAASLVLACGGCKKAEESPPPAPPAKPANPVKPPVQAQASSAQSVASVNPSLDFSGRKDPFKPFIQPKAEKPAAASGSIPAAGALPIQGYPVEQFKVSGIIAGFKENKALIVDPAGKGYVVKAGMKMGNNNGVIMRITPSYLEVAERVRNDVTGKISRRLVKLALPKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X26</accession>
    <name>Q39X26_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Valine--tRNA ligase</fullName>
            <ecNumber evidence="8">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Valyl-tRNA synthetase</fullName>
            <shortName evidence="8">ValRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 13" type="primary">valS</name>
        <name evidence="13" type="ordered locus">Gmet_0956</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal coiled-coil domain is crucial for aminoacylation activity.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514439.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0956"/>
    <dbReference type="EnsemblBacteria" id="ABB31198">
        <property type="protein sequence ID" value="ABB31198"/>
        <property type="gene ID" value="Gmet_0956"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0956"/>
    <dbReference type="eggNOG" id="COG0525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_0_2_7"/>
    <dbReference type="OMA" id="FATKLWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037118">
        <property type="entry name" value="Val-tRNA_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019499">
        <property type="entry name" value="Val-tRNA_synth_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="PTHR11946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10458">
        <property type="entry name" value="Val_tRNA-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 8 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="10">
        <location>
            <begin position="18"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="11">
        <location>
            <begin position="611"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Val_tRNA-synt_C" evidence="12">
        <location>
            <begin position="819"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="8">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="8">
        <location>
            <begin position="527"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="530"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="887" mass="101008" checksum="7BA1686223CBF443" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X36</accession>
    <name>Q39X36_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amino-acid acetyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">N-acetylglutamate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">argA</name>
        <name evidence="5" type="ordered locus">Gmet_0946</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514429.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0946"/>
    <dbReference type="EnsemblBacteria" id="ABB31188">
        <property type="protein sequence ID" value="ABB31188"/>
        <property type="gene ID" value="Gmet_0946"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0946"/>
    <dbReference type="eggNOG" id="COG1246">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119519_0_0_7"/>
    <dbReference type="OMA" id="IQEFWVA"/>
    <dbReference type="OrthoDB" id="1823496at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010167">
        <property type="entry name" value="NH2A_AcTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30602">
        <property type="entry name" value="PTHR30602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="16959" checksum="45DA0076C75ED0BC" modified="2005-11-22" version="1">MLRKAQIGDVKNIQKLLTHFASQGDMLSRSLSELYESIRDFYVWEEGGEIVGTAALHIIWEDLAEIRSVAVAEETGRKGIGTQVVNACIDEARQLGLKRVFCLTYKPNFFGTFGMRIVDKSELPHKVWGDCMKCVKFPDCDEIAMILDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X45</accession>
    <name>Q39X45_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514420.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0937"/>
    <dbReference type="EnsemblBacteria" id="ABB31179">
        <property type="protein sequence ID" value="ABB31179"/>
        <property type="gene ID" value="Gmet_0937"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0937"/>
    <dbReference type="eggNOG" id="COG0637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_19_3_7"/>
    <dbReference type="OMA" id="KAVIYDC"/>
    <dbReference type="OrthoDB" id="1167152at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="206" mass="23157" checksum="679C51AC12E1754A" modified="2005-11-22" version="1">MRYKAVIYDCDGVMFDSFEANLAFYQRIMGMMGRKPLDRSDEEQMRILHTYANREVLAHFFPDPREWEEAVRCAGRIDYRDLVPLMVMEQGFRETLDVLKGRVELAVCTNRSTSMDTVLESFDLASYFGLVMTASKVANPKPHPEPLLRVVEHFGIKPGEALFVGDSAVDSMAAEAAGVPFVAYKADLPAMTCIDHHGDLVALVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X65</accession>
    <name>Q39X65_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidylprolyl cis-trans isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31159.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513947.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0917"/>
    <dbReference type="EnsemblBacteria" id="ABB31159">
        <property type="protein sequence ID" value="ABB31159"/>
        <property type="gene ID" value="Gmet_0917"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0917"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023843_1_0_7"/>
    <dbReference type="OMA" id="DNSQGWI"/>
    <dbReference type="OrthoDB" id="1201303at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13145">
        <property type="entry name" value="Rotamase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="250"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31159.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="528" mass="58517" checksum="EA0EBECFB8EDCA5F" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XA8</accession>
    <name>Q39XA8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">tRNA (2-methylthio-N6-threonylcarbamyl-A37) methylthiotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">mtaB</name>
        <name evidence="11" type="ordered locus">Gmet_0874</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513020.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0874"/>
    <dbReference type="EnsemblBacteria" id="ABB31116">
        <property type="protein sequence ID" value="ABB31116"/>
        <property type="gene ID" value="Gmet_0874"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0874"/>
    <dbReference type="eggNOG" id="COG0621">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018697_1_0_7"/>
    <dbReference type="OMA" id="HFHIPLQ"/>
    <dbReference type="OrthoDB" id="397139at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035596">
        <property type="term" value="F:methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006467">
        <property type="entry name" value="MiaB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01061">
        <property type="entry name" value="methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01579">
        <property type="entry name" value="MiaB-like-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00089">
        <property type="entry name" value="TIGR00089"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50926">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MTTase N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="10">
        <location>
            <begin position="137"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="TRAM" evidence="8">
        <location>
            <begin position="370"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="431" mass="47271" checksum="37633CA2ACC28BC8" modified="2005-11-22" version="1">MQRVAISTLGCKINQFESAAMTESLGREGFRVVPFDEDADIYVINTCTVTAKTDAESRRLIRRALRRNPAARVVVTGCYAQVAPDAVKDLPGVALVVGNSEKRSIGELLRDAAPAEKVMVSDISRERTAEGLRLESFAEHTRAFLQVQNGCDAFCSYCIVPYARGRSRSVSFSEALAGIRNFAAQGFREVVLTGIHLGAYGLDLAPPTNLLALLEASEAEKAVPRLRVGSVEPNELTDALVDFLARSETVCPHLHIPLQSGDDRVLERMGRRYTAAFFRERVERLVAVVPDIFIGCDVIAGFPGETDEEFQNTVRLIEELPVASLHVFPYSRREGTAAARMEGQVDGKVIRGRAEILREVGERKRRSFCERFVGRELAVLMQNRGRDGEAVGLSRNYLPVRVPGYAGEMNAEATVMVTEVTPDGVGGIIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XH8</accession>
    <name>Q39XH8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADP-dependent menaquinol:acrylyl-CoA oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acuI</name>
        <name evidence="2" type="ordered locus">Gmet_0804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514391.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0804"/>
    <dbReference type="EnsemblBacteria" id="ABB31046">
        <property type="protein sequence ID" value="ABB31046"/>
        <property type="gene ID" value="Gmet_0804"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0804"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_26_3_7"/>
    <dbReference type="OMA" id="AQMDYNS"/>
    <dbReference type="OrthoDB" id="884088at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014188">
        <property type="entry name" value="Acrylyl-CoA_reductase_AcuI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF1">
        <property type="entry name" value="PTHR43677:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02823">
        <property type="entry name" value="oxido_YhdH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="13"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="334" mass="35131" checksum="FD64138B6B938AB3" modified="2005-11-22" version="1">MGNSVFKALVVEKTPEKQFVREIRERSIDDLPAGDLVVRVHYSSLNYKDALSATGHPGVTRQFPHTPGIDAAGEVVSCESGAFAPGDKVVVTGHDLGMETDGGWGQYIRIPSEWAVRLPEGLTLREAMALGTAGFTAALSVLKLERAGVRPDDGDILVTGATGGVGSIAVSILSRAGYRVTAATGKEFDEDFLKGLGATAVIGRDDVTAGAEKALLAERWAGAVDVVGGQTLAAVLKSTKYGGTVTCCGLVGSPELPMNVYPFILRGVSLLGIDSVQCPRGLREEVWQRLATAWKPSRLGEMVTECTLAGLEVMTQAILHGGITGRVVVNLQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XI5</accession>
    <name>Q39XI5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PEP motif-containing protein, putative exosortase substrate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0797"/>
    <dbReference type="EnsemblBacteria" id="ABB31039">
        <property type="protein sequence ID" value="ABB31039"/>
        <property type="gene ID" value="Gmet_0797"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0797"/>
    <dbReference type="HOGENOM" id="CLU_884979_0_0_7"/>
    <dbReference type="OMA" id="ESNDPAH"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223417" evidence="1">
        <location>
            <begin position="25"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="2">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="314" mass="32857" checksum="E258A7DCB16DA384" modified="2005-11-22" version="1">MKKGIFSFLVTTWLLTGTTVPASATTFQSHTLNTLSFSYVENLFDSNGTMKNGLELAPGDHLVGIISVNRIVAGGETIFTAGPTSQLTGIYAHKVLSIPPYLVNGQYAYDPLNPSSFQVHTEYGNPDLGAFTVGSSTVNLASILDPGAVLALWLDQGNSATSFTTEGTLADSVARATDGLPFLSAGIGNSGYFYSHTNQSVTMAELLNGAFIGQAFAGLEVLTNATGHGLSPIFNPGDLEKGTATPLVLSCDLGINPAFFSPEPASPWVLAGTGSVQVYPAPEPSTLALFGVAGSVMALCRLRKRTLNDREDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XM5</accession>
    <name>Q39XM5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513502.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0757"/>
    <dbReference type="EnsemblBacteria" id="ABB30999">
        <property type="protein sequence ID" value="ABB30999"/>
        <property type="gene ID" value="Gmet_0757"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0757"/>
    <dbReference type="eggNOG" id="ENOG5033R6D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_857508_0_0_7"/>
    <dbReference type="OMA" id="AGWVCGY"/>
    <dbReference type="OrthoDB" id="1145242at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="325" mass="35375" checksum="842D20E0A933E489" modified="2005-11-22" version="1">MAEQQTVTISCPQCASPFSFREGDRNARCPSCGTSLAISGEAGISRFWIEERIDLAQARANARRAVAAAGGDPDVVERLRFEGGELCFLPFWRLRGHAAGWLWTERETVTREEEYDENGMKTVREVRGPNQCATESVMVAVDYSSPACDVSRFGLRGIAVAGAVLPLRGMDFVLVSGRGTVFDPVKDPDEVRREAVAQARARGGGNGVIRSTGRFSLCGERLALISYPVWSLTFARDERLYPVTVDGVNGRVLAGRLPGSTRLTLLRPLLTVTLLVFAFTLHQLLGAAVAVGFLGWLAANGGLSPERLAGWFFALVERQREVELG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XQ7</accession>
    <name>Q39XQ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514442.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30967">
        <property type="protein sequence ID" value="ABB30967"/>
        <property type="gene ID" value="Gmet_0725"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0725"/>
    <dbReference type="eggNOG" id="ENOG502ZS0P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2142307_0_0_7"/>
    <dbReference type="OMA" id="EARVMWA"/>
    <dbReference type="OrthoDB" id="1839827at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="8"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="128" mass="14516" checksum="89DF1ADBB57802AA" modified="2005-11-22" version="1">MAEKRDITRHKKRLSLRFGTTTPTRLAYTEDVSAHGLFIKTTNLCPPGTRIQIELTLPDEEPVFLEGMVRWTKKVPPQMIHLVKKSGMGVMITKFIAGEMAYRHFIDELHARTGHSLPPAPLRSPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XT7</accession>
    <name>Q39XT7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">amtB</name>
        <name evidence="11" type="ordered locus">Gmet_0695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365710.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0695"/>
    <dbReference type="EnsemblBacteria" id="ABB30937">
        <property type="protein sequence ID" value="ABB30937"/>
        <property type="gene ID" value="Gmet_0695"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0695"/>
    <dbReference type="eggNOG" id="COG0004">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_33_0_7"/>
    <dbReference type="OMA" id="MACWNSN"/>
    <dbReference type="OrthoDB" id="562287at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="PTHR43029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223609" description="Ammonium transporter" evidence="9">
        <location>
            <begin position="25"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium_transp" evidence="10">
        <location>
            <begin position="76"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="488" mass="50256" checksum="9C8B0A90B2F61EAE" modified="2005-11-22" version="1">MKFKLSFVALLATVALSLPVALLAEEVKTAAPAQAALSSAQTAALAPAVTAAPAAAPATPAAPKNVDPVLNTGDTAWMLVSAAMVLFMIPGLAFFYGGMVRGKNVLSTIMHSFVAMGIVGVQWAVIGYSLSFGPDIGGGLLGNLSKALLNGLITFKDGNPVYALFQNVPTAPGAIPEYVFAMFQCMFAMITVALISGALAERVKFSAYCVFVLLWTTLVYDPLAHWVWMSDGWLFKKGALDFAGGTVVHLSSGISALAFLIFLGKRHGFPHERMAPHSLPLTMLGVGMLWFGWFGFNAGSAIVGANCSDAAGGLAGLAFATTTIAPAAGGLSWMIAEWIHAGKPSALGFGSGVVAGLVVITPAAGFVQPGAAILMGLAAGVVCYGGVLLKAKLKYDDSLDAFGVHGVGGTFGALTTGIFATVGATGLLSGNVSQFLTQVIAVVAAGAYAFIVTLVIAFVLHKTIGLRVEKEDEIMGLDQTQHSESAYN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y00</accession>
    <name>RS3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsC</name>
        <name type="ordered locus">Gmet_0632</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514242.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y00"/>
    <dbReference type="SMR" id="Q39Y00"/>
    <dbReference type="STRING" id="269799.Gmet_0632"/>
    <dbReference type="EnsemblBacteria" id="ABB30874">
        <property type="protein sequence ID" value="ABB30874"/>
        <property type="gene ID" value="Gmet_0632"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0632"/>
    <dbReference type="eggNOG" id="COG0092">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058591_0_2_7"/>
    <dbReference type="OMA" id="KTNPIGN"/>
    <dbReference type="OrthoDB" id="1132353at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01309_B">
        <property type="entry name" value="Ribosomal_S3_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005704">
        <property type="entry name" value="Ribosomal_S3_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_S3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_S3_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="SSF54814"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="SSF54821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01009">
        <property type="entry name" value="rpsC_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000230700" description="30S ribosomal protein S3">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="KH type-2" evidence="1">
        <location>
            <begin position="38"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01309"/>
        </source>
    </evidence>
    <sequence length="211" mass="23836" checksum="7C18B1953C036BA9" modified="2005-11-22" version="1">MGQKVNPIGFRLGVIRTWDSRWYAEADYAKLLHEDIKLRNFLKKRLFNSGVSKIEIERAASKAKINIFTARPGLIIGKKGAEVETLKKELAKLTDKEIYLNIQEVRKPELDAQLVSENVALQLERRVAFRRAMKKSVTSALKFGAKGIRITCSGRLGGAEMSRTEWYREGRVPLHTLRADIDYGFAEAKTTYGIIGVKVLIFKGEVLPGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y35</accession>
    <name>Q39Y35_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512294.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0596"/>
    <dbReference type="EnsemblBacteria" id="ABB30839">
        <property type="protein sequence ID" value="ABB30839"/>
        <property type="gene ID" value="Gmet_0596"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0596"/>
    <dbReference type="HOGENOM" id="CLU_2093357_0_0_7"/>
    <dbReference type="OMA" id="YWGYSLS"/>
    <dbReference type="OrthoDB" id="1871347at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="119" mass="13533" checksum="76B938E15B97B6F2" modified="2005-11-22" version="1">MKNNIRSIAVILNGFVHDFAAGIWLAAIASIALIHRMHQLRSPEVVAILNRLEHIFFWTSVVSMVFIMATGAGRTFTYVDNWYGADAERVRRRMLIIKHVVLLSAFGAGYLFVYPLVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y82</accession>
    <name>Q39Y82_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methionine synthase</fullName>
            <ecNumber evidence="6">2.1.1.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">5-methyltetrahydrofolate--homocysteine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="primary">metH</name>
        <name evidence="24" type="ordered locus">Gmet_0549</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="24 25" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:11172"/>
            <dbReference type="ChEBI" id="CHEBI:18608"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="2.1.1.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>methylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:28115"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetH route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the vitamin-B12 dependent methionine synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.13" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512245.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0549"/>
    <dbReference type="EnsemblBacteria" id="ABB30792">
        <property type="protein sequence ID" value="ABB30792"/>
        <property type="gene ID" value="Gmet_0549"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0549"/>
    <dbReference type="eggNOG" id="COG0646">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004914_0_2_7"/>
    <dbReference type="OMA" id="ADCIAMS"/>
    <dbReference type="OrthoDB" id="118138at2"/>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00081"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008705">
        <property type="term" value="F:methionine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042558">
        <property type="term" value="P:pteridine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003759">
        <property type="entry name" value="Cbl-bd_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006158">
        <property type="entry name" value="Cobalamin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036724">
        <property type="entry name" value="Cobalamin-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017215">
        <property type="entry name" value="MetH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036594">
        <property type="entry name" value="Meth_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000489">
        <property type="entry name" value="Pterin-binding_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02310">
        <property type="entry name" value="B12-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02607">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00809">
        <property type="entry name" value="Pterin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037472">
        <property type="entry name" value="DHPS_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01018">
        <property type="entry name" value="B12-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47644">
        <property type="entry name" value="SSF47644"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51717">
        <property type="entry name" value="SSF51717"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52242">
        <property type="entry name" value="SSF52242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="SSF82282"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51332">
        <property type="entry name" value="B12_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51337">
        <property type="entry name" value="B12_BINDING_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50972">
        <property type="entry name" value="PTERIN_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="16" id="KW-0170">Cobalt</keyword>
    <keyword evidence="13 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="8 19 24" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="11 19 24" id="KW-0808">Transferase</keyword>
    <keyword evidence="14 19" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="20">
        <location>
            <begin position="2"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Pterin-binding" evidence="21">
        <location>
            <begin position="322"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding N-terminal" evidence="23">
        <location>
            <begin position="589"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="B12-binding" evidence="22">
        <location>
            <begin position="683"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00025552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="ABB30792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="804" mass="84747" checksum="0FFB9C4722C2A2B6" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YD0</accession>
    <name>Q39YD0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0501</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512197.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0501"/>
    <dbReference type="DNASU" id="3738334"/>
    <dbReference type="EnsemblBacteria" id="ABB30744">
        <property type="protein sequence ID" value="ABB30744"/>
        <property type="gene ID" value="Gmet_0501"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0501"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="YELGANC"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="10"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="141" mass="15962" checksum="7EAAC1EEC3E9AB14" modified="2005-11-22" version="1">MTQQGAIKTRLILIEDEPGHTRLITKNLMKSADVEILPFDTGRRALEYFEGKTAEDLRQHLVVLDINMPGIDGFEVLKRLKGNEATAAVPVIVFTTTDHPDEIRRCYHEGANLYLVKPMDYTAFQVTIDFLAATLTMMRLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YD7</accession>
    <name>NIKR_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Putative nickel-responsive regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_0494</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcriptional regulator.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="1">Binds 1 nickel ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transcriptional regulatory CopG/NikR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512190.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YD7"/>
    <dbReference type="SMR" id="Q39YD7"/>
    <dbReference type="STRING" id="269799.Gmet_0494"/>
    <dbReference type="EnsemblBacteria" id="ABB30737">
        <property type="protein sequence ID" value="ABB30737"/>
        <property type="gene ID" value="Gmet_0494"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0494"/>
    <dbReference type="eggNOG" id="COG0864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113319_1_2_7"/>
    <dbReference type="OMA" id="AHNCLET"/>
    <dbReference type="OrthoDB" id="1885366at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010045">
        <property type="term" value="P:response to nickel cation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00476">
        <property type="entry name" value="NikR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027271">
        <property type="entry name" value="Acetolactate_synth/TF_NikR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002145">
        <property type="entry name" value="CopG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022988">
        <property type="entry name" value="Ni_resp_reg_NikR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014864">
        <property type="entry name" value="TF_NikR_Ni-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08753">
        <property type="entry name" value="NikR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01402">
        <property type="entry name" value="RHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0533">Nickel</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_1000014066" description="Putative nickel-responsive regulator">
        <location>
            <begin position="1"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00476"/>
        </source>
    </evidence>
    <sequence length="139" mass="15697" checksum="E6D24C399B279B3A" modified="2005-11-22" version="1">MGETVRFGISIDDKLLESFDRLIEQKGYMNRSEAVRDLIRAALVELKWEGGEEETVGTVTLVYNHHVRDLSDKLTEQQHSHHNEIVSALHVHLDAHNCLEVLVVRGKAREVKKIADELIGVKGVKHGKLVMTTTGEELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YF6</accession>
    <name>Q39YF6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter ATP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">cbiO</name>
        <name evidence="6" type="ordered locus">Gmet_0475</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Part of an ABC transporter complex. Responsible for energy coupling to the transport system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513844.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0475"/>
    <dbReference type="EnsemblBacteria" id="ABB30718">
        <property type="protein sequence ID" value="ABB30718"/>
        <property type="gene ID" value="Gmet_0475"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0475"/>
    <dbReference type="eggNOG" id="COG1122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="FVFQRPA"/>
    <dbReference type="OrthoDB" id="1752365at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006824">
        <property type="term" value="P:cobalt ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03225">
        <property type="entry name" value="ABC_cobalt_CbiO_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015856">
        <property type="entry name" value="ABC_transpr_CbiO/EcfA_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005876">
        <property type="entry name" value="Co_trans_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01166">
        <property type="entry name" value="cbiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="6"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="280" mass="31101" checksum="00D7665957B972F4" modified="2005-11-22" version="1">MAIARLSVDIRAFTYPDGTRALADIRFEVGKGEFCGILGSNGSGKTTLLRIMDGLVKDYDGQVLLDGRDVRKLHPRDIYRTVGLVFQNPDDQLFAHTVFEDVAFGPRNMGFGEAAVKGRVEEALAAVEMGELAGKNIHALSYGQKKRVCIAGLLAMGHEVLLMDEPTAGLDPMGEYRMMELLTRLNRDQGVTVVMATHSVDLVPLFLHRLHILSRGKIVRSGPPEEVFTAPAELESVKLRLPHIAELIHRLKHEDGLPFRRLPLTIGEARREIVEILQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YG3</accession>
    <name>Q39YG3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 19">Adenosylcobinamide-GDP ribazoletransferase</fullName>
            <ecNumber evidence="7 19">2.7.8.26</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18 19">Cobalamin synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 19">Cobalamin-5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19 20" type="primary">cobS</name>
        <name evidence="20" type="ordered locus">Gmet_0468</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16 19">Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate = adenosylcob(III)alamin 5'-phosphate + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23560"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="ChEBI" id="CHEBI:60493"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>adenosylcob(III)inamide-GDP + alpha-ribazole = adenosylcob(III)alamin + GMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16049"/>
            <dbReference type="ChEBI" id="CHEBI:10329"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.8.26"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 19">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 19">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 7/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="19">Cell inner membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 19">Belongs to the CobS family.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.26" evidence="7 19"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0468"/>
    <dbReference type="EnsemblBacteria" id="ABB30711">
        <property type="protein sequence ID" value="ABB30711"/>
        <property type="gene ID" value="Gmet_0468"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0468"/>
    <dbReference type="eggNOG" id="COG0368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057426_1_1_7"/>
    <dbReference type="OMA" id="GHTGDTY"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00238"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051073">
        <property type="term" value="F:adenosylcobinamide-GDP ribazoletransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008818">
        <property type="term" value="F:cobalamin 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00719">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003805">
        <property type="entry name" value="CobS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34148">
        <property type="entry name" value="PTHR34148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02654">
        <property type="entry name" value="CobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00317">
        <property type="entry name" value="cobS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="19" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="9 19" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 19" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="13 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="25"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00015850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00025228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00032605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ABB30711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="268" mass="28683" checksum="F16F27AF0BA94D49" modified="2005-11-22" version="1">MNMLKSHEQKRFFTGPRSPVPSPRLFFIAFQFLTIIPLPFTLRWEENDLGRSMAFFPLAGLTIGGLLAGADFLLAEVLPRPIEDLLLVALLAAMTGALHHDGLADVCDGLAARGSRDRFLAVMKDSRIGAVGVVGLVLGLLLKYQALLALSPEVKRQVLFFFPAVARFAQVQMTVGSRRAREDGLGAACIAGAGVTQLLVAGAITLAATYFLLGMKGIGCWAVLSLFTAGTKAWSHRRLGGVTGDVIGCASELNEIICLLIIVGMQKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YG8</accession>
    <name>Q39YG8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flagellar protein FlaG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">flaG</name>
        <name evidence="1" type="ordered locus">Gmet_0463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513832.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0463"/>
    <dbReference type="EnsemblBacteria" id="ABB30706">
        <property type="protein sequence ID" value="ABB30706"/>
        <property type="gene ID" value="Gmet_0463"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0463"/>
    <dbReference type="eggNOG" id="COG1334">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120910_4_4_7"/>
    <dbReference type="OMA" id="MEMHITS"/>
    <dbReference type="OrthoDB" id="2023323at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005186">
        <property type="entry name" value="FlaG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035924">
        <property type="entry name" value="FlaG-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37166">
        <property type="entry name" value="PTHR37166"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03646">
        <property type="entry name" value="FlaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160214">
        <property type="entry name" value="SSF160214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0966">Cell projection</keyword>
    <keyword evidence="1" id="KW-0969">Cilium</keyword>
    <keyword evidence="1" id="KW-0282">Flagellum</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="124" mass="13849" checksum="C35F869F93412614" modified="2005-11-22" version="1">MNVEFSNVARVVPGGATVAEPLKPSQAEERNKEVPVELPKTALKELLPAEQEERAKAAADRINEFIESFTRDLKFTIDKDSERVVLKVVDRKSGDVIRQIPSEEALKIAKALDELKGLIIREQV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YJ1</accession>
    <name>CSRA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translational regulator CsrA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csrA</name>
        <name type="ordered locus">Gmet_0440</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'-UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer; the beta-strands of each monomer intercalate to form a hydrophobic core, while the alpha-helices form wings that extend away from the core.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CsrA/RsmA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512412.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YJ1"/>
    <dbReference type="SMR" id="Q39YJ1"/>
    <dbReference type="STRING" id="269799.Gmet_0440"/>
    <dbReference type="EnsemblBacteria" id="ABB30683">
        <property type="protein sequence ID" value="ABB30683"/>
        <property type="gene ID" value="Gmet_0440"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0440"/>
    <dbReference type="eggNOG" id="COG1551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164837_0_2_7"/>
    <dbReference type="OMA" id="IHRKEVY"/>
    <dbReference type="OrthoDB" id="2032250at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048027">
        <property type="term" value="F:mRNA 5'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045947">
        <property type="term" value="P:negative regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902208">
        <property type="term" value="P:regulation of bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006109">
        <property type="term" value="P:regulation of carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00167">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003751">
        <property type="entry name" value="CsrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036107">
        <property type="entry name" value="CsrA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34984">
        <property type="entry name" value="PTHR34984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02599">
        <property type="entry name" value="CsrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117130">
        <property type="entry name" value="SSF117130"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00202">
        <property type="entry name" value="csrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_1000023384" description="Translational regulator CsrA">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00167"/>
        </source>
    </evidence>
    <sequence length="78" mass="8765" checksum="5650338588D44DF5" modified="2005-11-22" version="1">MLVLTRKMGETITIGDQIRIKVVEMKGNQVRLGIEAPGDMRIYREEIYLKVQKENQLAAAWSLEDLESAVNFAGAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YQ5</accession>
    <name>Q39YQ5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription termination factor Rho</fullName>
            <ecNumber evidence="8">3.6.4.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent helicase Rho</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 11" type="primary">rho</name>
        <name evidence="11" type="ordered locus">Gmet_0376</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. The homohexamer assembles into an open ring structure.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512348.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0376"/>
    <dbReference type="EnsemblBacteria" id="ABB30619">
        <property type="protein sequence ID" value="ABB30619"/>
        <property type="gene ID" value="Gmet_0376"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0376"/>
    <dbReference type="eggNOG" id="COG1158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016377_4_3_7"/>
    <dbReference type="OMA" id="TRLCRAH"/>
    <dbReference type="OrthoDB" id="1619125at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008186">
        <property type="term" value="F:ATP-dependent activity, acting on RNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04459">
        <property type="entry name" value="Rho_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01128">
        <property type="entry name" value="rho_factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01884">
        <property type="entry name" value="Rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041703">
        <property type="entry name" value="Rho_factor_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036269">
        <property type="entry name" value="Rho_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011113">
        <property type="entry name" value="Rho_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004665">
        <property type="entry name" value="Term_rho"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46425">
        <property type="entry name" value="PTHR46425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07497">
        <property type="entry name" value="Rho_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00959">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68912">
        <property type="entry name" value="SSF68912"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00767">
        <property type="entry name" value="rho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51856">
        <property type="entry name" value="RHO_RNA_BD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 8" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="Rho RNA-BD" evidence="10">
        <location>
            <begin position="48"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="166"/>
            <end position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="178"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="415" mass="46415" checksum="B44F0C43616E8CF3" modified="2005-11-22" version="1">MNLQELKGKKINELAAIAKGLNIEGASSLRKQDLIFAILNAQTEKNGMIFGEGVLECLPDGFGFLRAPDYNYLPGPDDIYVSPSQIRRFNLHTGDTVSGQIRPPKEGERYFALLKVETVNFEPPEVARDKILFDNLTPLYPDEKLKLETAPDNMPMRVLELVSPIGKGQRGLIVAPPRTGKTMLIQNIANSIAENHPEVYLIVLLIDERPEEVTDMQRSVRGEVVSSTFDEPATRHVQVAEMVIEKAKRLVEHKRDVVILLDSITRLARAYNTVLPPSGKILTGGVDANALQKPKRFFGAARNIEEGGSLTIIASALVDTGSKMDEVIFEEFKGTGNMEVHLDRKLVEKRTFPAIDINKSGTRKEELLVEKGSLNRTWILRKVLHPMNVVDSMEFLLEKLSETKSNQEFLDSMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YR0</accession>
    <name>Q39YR0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ech-hydrogenase-related complex, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ehrL-2</name>
        <name evidence="2" type="ordered locus">Gmet_0371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512343.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0371"/>
    <dbReference type="EnsemblBacteria" id="ABB30614">
        <property type="protein sequence ID" value="ABB30614"/>
        <property type="gene ID" value="Gmet_0371"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0371"/>
    <dbReference type="eggNOG" id="COG3261">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_3_1_7"/>
    <dbReference type="OMA" id="RGENVHW"/>
    <dbReference type="OrthoDB" id="473681at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex1_49kDa" evidence="1">
        <location>
            <begin position="265"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Complex1_49kDa" evidence="1">
        <location>
            <begin position="430"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="502" mass="54286" checksum="1F257A0CC74B3D62" modified="2005-11-22" version="1">MTRTFSLTCLRNGEAVPVASVPLLPLEQFLQDIIDATDRGWRVASCFGVPTDAGATLWCLMAAPNDGLLGLMRTEAGMAFPSICRLVPQLHLFEREIAEQCGITPEAHPWPKPVRFHHPFMPSRKGLGGKVAGDTDYYRVEGEEIHEVAVGPVHAGIIEPGHFRFQCHGEEVFSLEIALGYQHRGVEEGILKGPHPKTLFQMETIAGDTTIGHTLAYAMVMEALGGTVPSARAEIIRAISLELERLANHTGDLGALAGDVAYLPTASFCGRIRGDFLNMTAHICGSRFGRGIVRPGGVGFDVGERQAGELLDRLAAASDDLENAVGLLWDTQSVMARFEGTGKVSQETAREIGLVGPAARACGIDRDVRRDTPFGIYGVSPVAVAVEENGDVFARAHVRWREAEASLHFVAEQLRQLPAGPPVTNTATPAPDSVAVALTEGWRGEICHVAITDGTGRFARYKVVDPSFHNWTGLALALRNQQISDFPLCNKSFNLSYCGFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z29</accession>
    <name>Q39Z29_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">coxC</name>
        <name evidence="9" type="ordered locus">Gmet_0250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome c oxidase subunit 3 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513566.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0250"/>
    <dbReference type="EnsemblBacteria" id="ABB30495">
        <property type="protein sequence ID" value="ABB30495"/>
        <property type="gene ID" value="Gmet_0250"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0250"/>
    <dbReference type="eggNOG" id="COG1845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044071_1_0_7"/>
    <dbReference type="OMA" id="VWVFVFT"/>
    <dbReference type="OrthoDB" id="1502742at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019646">
        <property type="term" value="P:aerobic electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024791">
        <property type="entry name" value="Cyt_c/ubiquinol_Oxase_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000298">
        <property type="entry name" value="Cyt_c_oxidase-like_su3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035973">
        <property type="entry name" value="Cyt_c_oxidase_su3-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013833">
        <property type="entry name" value="Cyt_c_oxidase_su3_a-hlx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11403">
        <property type="entry name" value="PTHR11403"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00510">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81452">
        <property type="entry name" value="SSF81452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50253">
        <property type="entry name" value="COX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="COX3" evidence="8">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="200" mass="22059" checksum="A386ECC3BD366461" modified="2005-11-22" version="1">MSHQTRKDPAGAKLGMWLFLFTELFLFGGLFLLYGVYLARYHREFAAAGREMHLGFGTANTVILITSSLLAAMAVTAIQRSGRRLVLYLLGGTVLCGAVFLFNKYLEWSDEIGHGIYPGSPRLAAGPPGESVFYSLYYLTVGLHGLHVLIGGTLLAVVAARVGRGTIHAGDFAWLENGALYWHLVDLVWIFIFPLYYLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z30</accession>
    <name>Q39Z30_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome c oxidase subunit 1</fullName>
            <ecNumber evidence="8">7.1.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">coxA</name>
        <name evidence="10" type="ordered locus">Gmet_0249</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 8">
            <text>4 Fe(II)-[cytochrome c] + 8 H(+)(in) + O2 = 4 Fe(III)-[cytochrome c] + 4 H(+)(out) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11436"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="7.1.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the heme-copper respiratory oxidase family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.9" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513565.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0249"/>
    <dbReference type="EnsemblBacteria" id="ABB30494">
        <property type="protein sequence ID" value="ABB30494"/>
        <property type="gene ID" value="Gmet_0249"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0249"/>
    <dbReference type="eggNOG" id="COG0843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011899_7_3_7"/>
    <dbReference type="OMA" id="WAMMSIG"/>
    <dbReference type="OrthoDB" id="316745at2"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006119">
        <property type="term" value="P:oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023616">
        <property type="entry name" value="Cyt_c_oxase-like_su1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023615">
        <property type="entry name" value="Cyt_c_Oxase_su1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014241">
        <property type="entry name" value="Cyt_c_oxidase_su1_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01165">
        <property type="entry name" value="CYCOXIDASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02891">
        <property type="entry name" value="CtaD_CoxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50855">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00077">
        <property type="entry name" value="COX1_CUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="COX1" evidence="9">
        <location>
            <begin position="26"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="541" mass="59489" checksum="37E22CF155B37507" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z45</accession>
    <name>Q39Z45_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513549.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0234"/>
    <dbReference type="EnsemblBacteria" id="ABB30479">
        <property type="protein sequence ID" value="ABB30479"/>
        <property type="gene ID" value="Gmet_0234"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0234"/>
    <dbReference type="eggNOG" id="ENOG5032S0D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119887_1_0_7"/>
    <dbReference type="OMA" id="VPPDYYP"/>
    <dbReference type="OrthoDB" id="2008495at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025693">
        <property type="entry name" value="Gly-zipper_OmpA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13436">
        <property type="entry name" value="Gly-zipper_OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223331" evidence="2">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Gly-zipper_OmpA" evidence="3">
        <location>
            <begin position="71"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="174" mass="17793" checksum="2FEEE40598665063" modified="2005-11-22" version="1">MVVNWLQRYATVAALMVLGGCATVPSGPSVLVLPAPGKPFEQFQVEDATCRQWAGQQIGLSAQETVNQNTAQSAAVGTAIGAGAGALLGAAAGHPAAGAAIGAGSGLLVGTASGSGAGEAYGWEAQQKYDYAYVQCMYAKGNQVPGRVHRYRLKRVAPSPSSPDRYSVPPDYVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z60</accession>
    <name>Q39Z60_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0218</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30464">
        <property type="protein sequence ID" value="ABB30464"/>
        <property type="gene ID" value="Gmet_0218"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0218"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_939290_0_0_7"/>
    <dbReference type="OMA" id="WIAINTS"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="296" mass="33172" checksum="C84126E93F812F78" modified="2005-11-22" version="1">MSFLLSRTVHGAGGPSGGAAQNMEPRLAVTPAVMDYAVNTVKPVLDASPDKDRLSQLLKVVDVLKDPKMGVDVNRIAPDAYFIYNLLDKVKLGFLYTWKFSPEQKEMLQRWHGKYMNEHPADVFFAPTADEIIKTRAGFGCTHYARAFIAVVKALGLVEKPEDLRYVVSSKADDYNRALEKQDMEKTINGHQFVLVKIDSRWIAINTSQREEAVNMPEGFSPESCSPPQNIPVRFESYPAGIIFLLRKIGKDFNDDCGDISLANLMNISRSGNTENGMFLWEPYGTVNQSFPGRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z83</accession>
    <name>Q39Z83_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylglycerophosphatase A</fullName>
            <ecNumber evidence="1">3.1.3.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphatidylglycerolphosphate phosphatase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">pgpA</name>
        <name evidence="4" type="ordered locus">Gmet_0195</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:33751"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="EC" id="3.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="3.1.3.27" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512784.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0195"/>
    <dbReference type="EnsemblBacteria" id="ABB30441">
        <property type="protein sequence ID" value="ABB30441"/>
        <property type="gene ID" value="Gmet_0195"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0195"/>
    <dbReference type="eggNOG" id="COG1267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103734_0_1_7"/>
    <dbReference type="OMA" id="TLFFSGY"/>
    <dbReference type="OrthoDB" id="1969080at2"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00504"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008962">
        <property type="term" value="F:phosphatidylglycerophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006655">
        <property type="term" value="P:phosphatidylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06971">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026037">
        <property type="entry name" value="PgpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036681">
        <property type="entry name" value="PgpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007686">
        <property type="entry name" value="YutG/PgpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36305">
        <property type="entry name" value="PTHR36305"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04608">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006162">
        <property type="entry name" value="PgpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101307">
        <property type="entry name" value="SSF101307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0595">Phospholipid degradation</keyword>
    <keyword evidence="1" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="PgpA" evidence="3">
        <location>
            <begin position="8"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="149" mass="16479" checksum="9B4EEFB8AFD6396B" modified="2005-11-22" version="1">MRGFVVCAASWFGTGFFPVASGTVGTLGAIPLYLVLARLPLWLYLLTLVPFFFLASWVSGAAEREFGEKDSGKIVIDEVIGFLITMAGAPVHWRSIVIGFLLFRFFDIVKVPPARYFDRQVKNGYGVVLDDVVAGIYACVVLHVILRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZI8</accession>
    <name>Q39ZI8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514743.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0087"/>
    <dbReference type="EnsemblBacteria" id="ABB30336">
        <property type="protein sequence ID" value="ABB30336"/>
        <property type="gene ID" value="Gmet_0087"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0087"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_830949_0_0_7"/>
    <dbReference type="OMA" id="YGTDMPL"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="80"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="334" mass="36648" checksum="58EF0ECAC9E320E7" modified="2005-11-22" version="1">MTVIDIHCHAAGIGAGDSGCFISPKLRRSWKYRFYLKSFGVTNADLEREGDSLVLRRISERLTASSQVQQAVVLAMDGVVDGSGQLDRDRTEMYIPNEFLARECRRYPNLLFGASVNPQRPDALERLDAAAAAGAVLVKWLPSIQGTDPADRCLVPFYRHLAQLGLPLLTHTGLEESFTLADNALADPARLRLPLEEGVTVIAAHCATSGQSHGESNLARLLPLFAQFPNLYADISALTQLNRLGHLERVLAHRDIHGRLLYGTDMPLPATGLTSPWFHLLRLGPLEARRLAVIGNPWDQDVALKLALGMPEEILFRAAGVLGIADTIKHRSFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZP9</accession>
    <name>Q39ZP9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0025</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513791.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0025"/>
    <dbReference type="EnsemblBacteria" id="ABB30275">
        <property type="protein sequence ID" value="ABB30275"/>
        <property type="gene ID" value="Gmet_0025"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0025"/>
    <dbReference type="eggNOG" id="COG2952">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163266_1_0_7"/>
    <dbReference type="OMA" id="KMLRMIK"/>
    <dbReference type="OrthoDB" id="2032154at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007463">
        <property type="entry name" value="DUF507"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04368">
        <property type="entry name" value="DUF507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="94" mass="10518" checksum="491040583BF2EC94" modified="2005-11-22" version="1">MKLKEAQIARLAEQVLERLITAGLINLKAERGVVLDRIKKAVASDAKGEEDLEREAERLLEQTLRSMGGGVGIDRHKMLKMIKERLAKEKGIVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYC3</accession>
    <name>J7LYC3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3648"/>
    <dbReference type="EnsemblBacteria" id="AFR42793">
        <property type="protein sequence ID" value="AFR42793"/>
        <property type="gene ID" value="Gmet_3648"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3648"/>
    <dbReference type="HOGENOM" id="CLU_3252122_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="42" mass="4731" checksum="8080B1D137FC6058" modified="2012-10-31" version="1">MTSSEIIVTAIIWLLTAIGGFFALRGALRRRREATRSSKHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="21" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYI3</accession>
    <name>J7LYI3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3632</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3632"/>
    <dbReference type="EnsemblBacteria" id="AFR42848">
        <property type="protein sequence ID" value="AFR42848"/>
        <property type="gene ID" value="Gmet_3632"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3632"/>
    <dbReference type="HOGENOM" id="CLU_3200297_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="45" mass="5060" checksum="98A70231C5CBFE6E" modified="2012-10-31" version="1">MVDIRTRIAVTITCNTFRIQFYVFIAHLAPPLNQIVSSNGKPSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>J7M0A7</accession>
    <name>J7M0A7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2491"/>
    <dbReference type="EnsemblBacteria" id="AFR42837">
        <property type="protein sequence ID" value="AFR42837"/>
        <property type="gene ID" value="Gmet_2491"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2491"/>
    <dbReference type="eggNOG" id="COG5499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125852_5_1_7"/>
    <dbReference type="OMA" id="IGKSNRV"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039060">
        <property type="entry name" value="Antitox_HigA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40455">
        <property type="entry name" value="PTHR40455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="61"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="125" mass="14397" checksum="92A466F18675EE52" modified="2012-10-31" version="1">MEIRPIKTEVDYQAALKEIELLFDAAPDTPEGDRLDVLAILVEAYEERRYSIPMPDPIEAILYYMESRGLTRRDLEPYIGSRARVSEVLNRKRSLTMEMIRNLHKGLGIPADVLIQPYNTYKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PU0</accession>
    <name>Q39PU0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Poly-gamma-glutamate capsule biosynthesis protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CapA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513685.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3529"/>
    <dbReference type="EnsemblBacteria" id="ABB33734">
        <property type="protein sequence ID" value="ABB33734"/>
        <property type="gene ID" value="Gmet_3529"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3529"/>
    <dbReference type="eggNOG" id="COG2843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038823_2_2_7"/>
    <dbReference type="OMA" id="MKERFTL"/>
    <dbReference type="OrthoDB" id="1003186at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07381">
        <property type="entry name" value="MPP_CapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019079">
        <property type="entry name" value="Capsule_synth_CapA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09587">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00854">
        <property type="entry name" value="PGA_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223410" evidence="2">
        <location>
            <begin position="22"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="PGA_cap" evidence="3">
        <location>
            <begin position="26"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="349" mass="37918" checksum="322A26CFDBCF0CF6" modified="2005-11-22" version="1">MRQVRLMLAAIVTLLAVPALGADGIVITCVGDIMLAGSATPTLSRSGYDYPFAKTAQELRRGDIAMGNLEAPLTERGTEYRDKTYRFRTNPIAAAALKRAGFSVLTLANNHMMDYGNEGLQDTLATLSRHGIAHTGAGASLAEARREAVVSVRGKRIAFLAYSLTFPSEFYAGPNRPGTAPGYAPHVREDIRRAKAEADYVVVSFHWGAERAEFPKQYQTETARLAIDAGADAIIGHHPHVLQGIEFYRGKPILYSLGNFAFGSRSTAADRSVMARLTLSDEETSVELVPLNVLHRETRYQPGILAGRKGAEVIERLNRLSQPFGTVISGSAGRFRARTSGADQRIATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PU6</accession>
    <name>Q39PU6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Isoprenoid biosynthesis amidotransferase-like protein ElbB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">elbB</name>
        <name evidence="2" type="ordered locus">Gmet_3523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513680.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3523"/>
    <dbReference type="EnsemblBacteria" id="ABB33728">
        <property type="protein sequence ID" value="ABB33728"/>
        <property type="gene ID" value="Gmet_3523"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3523"/>
    <dbReference type="eggNOG" id="COG3155">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072952_1_0_7"/>
    <dbReference type="OMA" id="AQVQCFA"/>
    <dbReference type="OrthoDB" id="1421548at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026041">
        <property type="entry name" value="ElbB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10224:SF12">
        <property type="entry name" value="PTHR10224:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006320">
        <property type="entry name" value="Elb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DJ-1_PfpI" evidence="1">
        <location>
            <begin position="77"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="217" mass="22715" checksum="4CF183DC19D9E5C6" modified="2005-11-22" version="1">MKKIGVVLSGCGVYDGSEIHEAVFTLLAIDRNGAEAVCLAPDMEFREVNHLTSQETGAVRNTLVESARIARGKIRNVAEIAAADLDAVVFPGGFGAAKNLCNFAEKGADAAIHPEVARLIREMALAKKPIGAICIAPALIAATLGRDYKPKVTIGTDAGTAAAIAATGSEHVDCPVTEFVVDRENKIVTTPAYMLANRISEAAEGIEKAVKTVIDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PX5</accession>
    <name>Q39PX5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iron-sulfur cluster repair protein ScdA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">scdA</name>
        <name evidence="5" type="ordered locus">Gmet_3494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513651.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3494"/>
    <dbReference type="DNASU" id="3739035"/>
    <dbReference type="EnsemblBacteria" id="ABB33699">
        <property type="protein sequence ID" value="ABB33699"/>
        <property type="gene ID" value="Gmet_3494"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3494"/>
    <dbReference type="eggNOG" id="COG2846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076075_0_1_7"/>
    <dbReference type="OMA" id="ACTTWRV"/>
    <dbReference type="OrthoDB" id="1701106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019903">
        <property type="entry name" value="RIC_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36438">
        <property type="entry name" value="PTHR36438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04405">
        <property type="entry name" value="ScdA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03652">
        <property type="entry name" value="FeS_repair_RIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="4">
        <location>
            <begin position="89"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="249" mass="28129" checksum="E85127B17D8EC645" modified="2005-11-22" version="1">MMEDTKTQQEDAGAVRTIGGFVAEDYRTAEVFERHGIDFCCGGNVPLDTACRQKGIDPAVILDEIEAAKREPMERSQNFAVWELSFLADYIVAVHHAYIKDNAGQIVLYARKVAEVHGGRHAEVKEIAAIFEKVAADLATHLREEEEIFFPAVKRADAAKKAGKRPERQDIDAIRGDLARLRREHEEVGDAIHTIRRLAGDFAIPDDACNTYAVTYRKLKEFEDDLHKHVHLENNILFLNAERDLGDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PY3</accession>
    <name>Q39PY3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513643.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3486"/>
    <dbReference type="EnsemblBacteria" id="ABB33691">
        <property type="protein sequence ID" value="ABB33691"/>
        <property type="gene ID" value="Gmet_3486"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3486"/>
    <dbReference type="eggNOG" id="ENOG50339KM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2303259_0_0_7"/>
    <dbReference type="OMA" id="IANQAMD"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016367">
        <property type="entry name" value="MOM_Lpp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021793">
        <property type="entry name" value="Oprl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38763">
        <property type="entry name" value="PTHR38763"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11839">
        <property type="entry name" value="Alanine_zipper"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="100" mass="10658" checksum="B7245F6BDF98C2F5" modified="2005-11-22" version="1">MKGILLLIAMLLVLPVTMIGCATSGDLERVQADQRMLDAKVEQAVQDAQAAKASADAAKAKADNATARADSAIKAAEERERIADEKAKKADATFQKSMRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q47</accession>
    <name>Q39Q47_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Selenocysteine-specific elongation factor</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">SelB translation factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">selB</name>
        <name evidence="7" type="ordered locus">Gmet_3415</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366189.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3415"/>
    <dbReference type="EnsemblBacteria" id="ABB33627">
        <property type="protein sequence ID" value="ABB33627"/>
        <property type="gene ID" value="Gmet_3415"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3415"/>
    <dbReference type="eggNOG" id="COG3276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023030_3_0_7"/>
    <dbReference type="OMA" id="WVDRAFT"/>
    <dbReference type="OrthoDB" id="244339at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015190">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015191">
        <property type="entry name" value="Elong_fac_SelB-wing-hlx_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004535">
        <property type="entry name" value="Transl_elong_SelB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09106">
        <property type="entry name" value="SelB-wing_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09107">
        <property type="entry name" value="SelB-wing_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00475">
        <property type="entry name" value="selB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="6">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00015953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="636" mass="69626" checksum="61C3657F3D72682C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q58</accession>
    <name>PDXA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-hydroxythreonine-4-phosphate dehydrogenase</fullName>
            <ecNumber evidence="1">1.1.1.262</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-(phosphohydroxy)-L-threonine dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxA</name>
        <name type="ordered locus">Gmet_3404</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-(phosphooxy)-L-threonine + NAD(+) = 3-amino-2-oxopropyl phosphate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32275"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="EC" id="1.1.1.262"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit. Can use ions such as Zn(2+), Mg(2+) or Co(2+).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 4/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The active site is located at the dimer interface.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PdxA family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.262" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366188.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Q58"/>
    <dbReference type="SMR" id="Q39Q58"/>
    <dbReference type="STRING" id="269799.Gmet_3404"/>
    <dbReference type="EnsemblBacteria" id="ABB33616">
        <property type="protein sequence ID" value="ABB33616"/>
        <property type="gene ID" value="Gmet_3404"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3404"/>
    <dbReference type="eggNOG" id="COG1995">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040168_0_0_7"/>
    <dbReference type="OMA" id="TAQVVMM"/>
    <dbReference type="OrthoDB" id="1414545at2"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00312"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050570">
        <property type="term" value="F:4-hydroxythreonine-4-phosphate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00536">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037510">
        <property type="entry name" value="PdxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005255">
        <property type="entry name" value="PdxA_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30004">
        <property type="entry name" value="PTHR30004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04166">
        <property type="entry name" value="PdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00557">
        <property type="entry name" value="pdxA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0170">Cobalt</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000051501" description="4-hydroxythreonine-4-phosphate dehydrogenase">
        <location>
            <begin position="1"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00536"/>
        </source>
    </evidence>
    <sequence length="339" mass="36281" checksum="7D2A3BFA7F1C7DF8" modified="2005-11-22" version="1">MPNTKPRIVITMGDPTGVGPEIIAATLAEPEVRQCCRFLVVGDSAAMARGITVAGAALRVERTDTLNWEESKEGVLPLWEISSLTEADMQYGCPTVASGDAMYRAICEAARLCLEGNADAMATAPISKEALNRAGHRYPGHTELLAELAGAERVVMMLAGFRLRVTLVTIHEALADVPRLVTFERVLETIRITHRDLHRYFRRNPRIAVLALNPHCGEGGMFGDEEARIIAPAVAAARQEGIDAIGPLSADTLFHFAVQGAYDAVVCMYHDQGLIPLKLLHFDDGVNVTLGLPIIRTSVDHGTAYDLAGTGRASAESMKAAILMAAEMARVKGSGGGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q68</accession>
    <name>Q39Q68_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33606.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512620.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3394"/>
    <dbReference type="EnsemblBacteria" id="ABB33606">
        <property type="protein sequence ID" value="ABB33606"/>
        <property type="gene ID" value="Gmet_3394"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3394"/>
    <dbReference type="HOGENOM" id="CLU_1523043_0_0_7"/>
    <dbReference type="OMA" id="VEMGRMR"/>
    <dbReference type="OrthoDB" id="1905536at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33606.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="176" mass="20151" checksum="1F7404F6C62A6FDF" modified="2012-10-31" version="2">MTARRWLWGWILLLCFLVTPGCYYFRLAAEPLQKSRIVTVRPADEVFALVKNLLMKDGYVIAEEDPKNHLLLTELRHISTRAGGVTLPEGGRLYYHRLRVAVDGGEEGAAVELESRDLEIRSRYVYEEGGKVLSFMKRYPYDHYPSMFDLSTVNVEMGRMRRYLESTLGEGGANGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q72</accession>
    <name>Q39Q72_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclic dehypoxanthine futalosine synthase</fullName>
            <shortName evidence="6">Cyclic DHFL synthase</shortName>
            <ecNumber evidence="6">1.21.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Dehypoxanthine futalosine cyclase</fullName>
            <shortName evidence="6">DHFL cyclase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Menaquinone biosynthetic enzyme MqnC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mqnC-1</name>
        <name evidence="6" type="synonym">mqnC</name>
        <name evidence="8" type="ordered locus">Gmet_3390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>dehypoxanthine futalosine + S-adenosyl-L-methionine = 5'-deoxyadenosine + cyclic dehypoxanthinylfutalosinate + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:33083"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:58864"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64270"/>
            <dbReference type="EC" id="1.21.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the radical SAM superfamily. MqnC family.</text>
    </comment>
    <dbReference type="EC" id="1.21.98.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512616.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3390"/>
    <dbReference type="EnsemblBacteria" id="ABB33602">
        <property type="protein sequence ID" value="ABB33602"/>
        <property type="gene ID" value="Gmet_3390"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3390"/>
    <dbReference type="eggNOG" id="COG1060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040406_1_0_7"/>
    <dbReference type="OMA" id="ATMMFGS"/>
    <dbReference type="OrthoDB" id="419725at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046992">
        <property type="term" value="F:oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00992">
        <property type="entry name" value="MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045567">
        <property type="entry name" value="CofH/MnqC-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022431">
        <property type="entry name" value="Cyclic_DHFL_synthase_mqnC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034405">
        <property type="entry name" value="F420"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020050">
        <property type="entry name" value="FO_synthase_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43076">
        <property type="entry name" value="PTHR43076"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19288">
        <property type="entry name" value="CofH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00343">
        <property type="entry name" value="aminofutalosine_synthase_(mqnE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03699">
        <property type="entry name" value="menaquin_MqnC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00423">
        <property type="entry name" value="TIGR00423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="48"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="353" mass="39117" checksum="A6BB3338D70820B1" modified="2005-11-22" version="1">MDTVIEKIEQGEAVDRAEALHLLTRADLLTLGRLADGIRRRLHPEEVVTFVVDRNVNYTNVCESRCKFCAFYREEGAPDAYLLAEEAIYAKIAELVEHGGTQLLMQGGLHPHLGIEWFERLFREIKERFPQVQNHSLSPAEITQIATVSKLTIPETVRRLREAGLDSIPGGGAEILVDRVRKEISPKKIGWEGWAAVMGEAARQGMATTATMMFGSTEKPEDIAEHLFRVRELQAAGGSFTAFIPWTYQPGNTELGGGSATGVEYLKVLALSRIVLHNVPNIQASWVTQGGQMAQVALFFGANDLGGTMLEENVVAAAGCTFRMSLDEMVELIREAGFRPAQRTTLYKIIREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q96</accession>
    <name>Q39Q96_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">General secretion pathway protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="primary">gspF</name>
        <name evidence="18" type="ordered locus">Gmet_3366</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="18 19" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the type II secretion system inner membrane complex required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Cell inner membrane</location>
            <topology evidence="3 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512592.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3366"/>
    <dbReference type="EnsemblBacteria" id="ABB33578">
        <property type="protein sequence ID" value="ABB33578"/>
        <property type="gene ID" value="Gmet_3366"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3366"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035032_0_1_7"/>
    <dbReference type="OMA" id="VAEQCEK"/>
    <dbReference type="OrthoDB" id="1596769at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011850">
        <property type="entry name" value="T2SS_GspF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001992">
        <property type="entry name" value="T2SS_GspF/T4SS_PilC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02120">
        <property type="entry name" value="GspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00874">
        <property type="entry name" value="T2SP_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="17">
        <location>
            <begin position="70"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="17">
        <location>
            <begin position="272"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="ABB33578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="403" mass="43478" checksum="A00C8749915EF48C" modified="2005-11-22" version="1">MPTFRYSAYTAEGRDTAGTLEAENLKEARQRLKRDGLFPREISPAEDEGAAPGRRLFGGHTGLAEIALMTRRLATLVGSQVPIFEAVTTLGEQEEPGELKKALGRIRERLAEGASLAKALSLEPGLFSESYVAMVAAGEASGSLETVLEKLALFLEEQRAIRSKVTASLAYPLLMIVVGGGVMLFLLTFVIPKIVTIFEDNKAALPLITIALIKTSAFLRHFWWALLGLAAGGVFLYRRLATQEGFRLRRDRWLLGLPVVGGLIRHLILSRFAKVLGLLLASGVPVIKALEITAQVLVNRVYRGSLHTIAAELAEGGNLSGALRKGTLFPPLLIHMVAVGEKGGELEEMLAKAGNAFEREFDTAVSGLMALLEPLLVLAMGLAVGLVVLAVLLPIFELNQLVR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QA2</accession>
    <name>ATPL_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit c</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(0) sector subunit c</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit c</fullName>
            <shortName evidence="1">F-ATPase subunit c</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpE</name>
        <name type="ordered locus">Gmet_3360</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase C chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512586.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QA2"/>
    <dbReference type="SMR" id="Q39QA2"/>
    <dbReference type="STRING" id="269799.Gmet_3360"/>
    <dbReference type="EnsemblBacteria" id="ABB33572">
        <property type="protein sequence ID" value="ABB33572"/>
        <property type="gene ID" value="Gmet_3360"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3360"/>
    <dbReference type="eggNOG" id="COG0636">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_148047_2_0_7"/>
    <dbReference type="OMA" id="ALIFRQY"/>
    <dbReference type="OrthoDB" id="2078221at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005953">
        <property type="entry name" value="ATP_synth_csu_bac/chlpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="PTHR10031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="SSF81333"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01260">
        <property type="entry name" value="ATP_synt_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0446">Lipid-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000365885" description="ATP synthase subunit c">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="4"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="site" description="Reversibly protonated during proton transport" evidence="1">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01396"/>
        </source>
    </evidence>
    <sequence length="91" mass="9371" checksum="4DBEC887CB405289" modified="2005-11-22" version="1">MDFLTMCMLAAGFGMAIGAFGTGIGQGLAVKSAVEGVSRNPGASGKILTTMMIGLAMIESLAIYVLVVCLIILFANPYKDVAIKLAETVAK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-02-10" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QA3</accession>
    <name>ATP6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit a</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F0 sector subunit a</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpB</name>
        <name type="ordered locus">Gmet_3359</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase A chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512585.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QA3"/>
    <dbReference type="SMR" id="Q39QA3"/>
    <dbReference type="STRING" id="269799.Gmet_3359"/>
    <dbReference type="EnsemblBacteria" id="ABB33571">
        <property type="protein sequence ID" value="ABB33571"/>
        <property type="gene ID" value="Gmet_3359"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3359"/>
    <dbReference type="eggNOG" id="COG0356">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041018_2_2_7"/>
    <dbReference type="OMA" id="FTHAVRL"/>
    <dbReference type="OrthoDB" id="867266at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01393">
        <property type="entry name" value="ATP_synth_a_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045082">
        <property type="entry name" value="ATP_syn_F0_a_bact/chloroplast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000568">
        <property type="entry name" value="ATP_synth_F0_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023011">
        <property type="entry name" value="ATP_synth_F0_asu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035908">
        <property type="entry name" value="F0_ATP_A_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42823">
        <property type="entry name" value="PTHR42823"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00119">
        <property type="entry name" value="ATP-synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00123">
        <property type="entry name" value="ATPASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81336">
        <property type="entry name" value="SSF81336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01131">
        <property type="entry name" value="ATP_synt_6_or_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00449">
        <property type="entry name" value="ATPASE_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000362312" description="ATP synthase subunit a">
        <location>
            <begin position="1"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01393"/>
        </source>
    </evidence>
    <sequence length="229" mass="25527" checksum="9D4927FA1362ABF7" modified="2005-11-22" version="1">MVHPLLFLQFFRKLLEPLHISEAGADAIAYTWLIIVFLLIVSLIATKALKAVPTGMQNFMEVVVGGIENMVEETMGEKGRPYFPLIATLALFVLVSNLIGLIPGFFPPTANLNTTAACAIIVFLSTHVVGIKKHGFHYLQHFMGPIWWLAPLMFFIEIIGHLSRPLSLSLRLFGNMNGHELVLMIFFALAPFLVPLPMMLMGVLVSFIQAFVFMLLAMIYIQGSLEEAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QC7</accession>
    <name>Q39QC7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LUD_dom domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512558.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3334"/>
    <dbReference type="DNASU" id="3740649"/>
    <dbReference type="EnsemblBacteria" id="ABB33547">
        <property type="protein sequence ID" value="ABB33547"/>
        <property type="gene ID" value="Gmet_3334"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3334"/>
    <dbReference type="eggNOG" id="COG1139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107893_1_0_7"/>
    <dbReference type="OMA" id="RACRIYS"/>
    <dbReference type="OrthoDB" id="1100576at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003741">
        <property type="entry name" value="LUD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009501">
        <property type="entry name" value="UCP020269"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02589">
        <property type="entry name" value="LUD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF020269">
        <property type="entry name" value="DUF1121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LUD_dom" evidence="1">
        <location>
            <begin position="17"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="217" mass="23855" checksum="6B4022B0AC779936" modified="2005-11-22" version="1">MSLTTELVDWTHEQKCRKAVASLEKNGFTAVYCGTGQEALEYIVAEAAEAESVGFGGSMSVDDLKVIERIREMGKELLIHGAPGLSLEERVTIMRRQLTCDLFLAGTNALTLSGWLVNIDATGNRVGSMFFGPRKVIVVAGRNKIVDGGVQEAIDRIKEWASPPNARRLNYKTPCGTTGFCSDCNSPDRICRITTVIDRKPRLTDLRVLVVNEEMGF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QU2</accession>
    <name>PCKA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoenolpyruvate carboxykinase (ATP)</fullName>
            <shortName evidence="1">PCK</shortName>
            <shortName evidence="1">PEP carboxykinase</shortName>
            <shortName evidence="1">PEPCK</shortName>
            <ecNumber evidence="1">4.1.1.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pckA</name>
        <name type="ordered locus">Gmet_3169</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + oxaloacetate = ADP + CO2 + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18617"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.49"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="1">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.49" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513885.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QU2"/>
    <dbReference type="SMR" id="Q39QU2"/>
    <dbReference type="STRING" id="269799.Gmet_3169"/>
    <dbReference type="PRIDE" id="Q39QU2"/>
    <dbReference type="EnsemblBacteria" id="ABB33382">
        <property type="protein sequence ID" value="ABB33382"/>
        <property type="gene ID" value="Gmet_3169"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3169"/>
    <dbReference type="eggNOG" id="COG1866">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018247_0_1_7"/>
    <dbReference type="OMA" id="MRYAGEM"/>
    <dbReference type="OrthoDB" id="146648at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004612">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00484">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00453">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001272">
        <property type="entry name" value="PEP_carboxykinase_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015994">
        <property type="entry name" value="PEPCK_ATP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30031">
        <property type="entry name" value="PTHR30031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01293">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006294">
        <property type="entry name" value="PEP_crbxkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00224">
        <property type="entry name" value="pckA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00532">
        <property type="entry name" value="PEPCK_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0312">Gluconeogenesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000236924" description="Phosphoenolpyruvate carboxykinase (ATP)">
        <location>
            <begin position="1"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="60"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="237"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00453"/>
        </source>
    </evidence>
    <sequence length="530" mass="58150" checksum="C0A192FA62E80D38" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QU7</accession>
    <name>Q39QU7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix XRE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513880.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3164"/>
    <dbReference type="EnsemblBacteria" id="ABB33377">
        <property type="protein sequence ID" value="ABB33377"/>
        <property type="gene ID" value="Gmet_3164"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3164"/>
    <dbReference type="eggNOG" id="COG1396">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_911412_0_0_7"/>
    <dbReference type="OMA" id="ENNRYPT"/>
    <dbReference type="OrthoDB" id="1289539at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="HTH cro/C1-type" evidence="2">
        <location>
            <begin position="25"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="315" mass="34304" checksum="605BCF4CDC77E05E" modified="2005-11-22" version="1">METQDEKSERERSVPPIVAIDGTAIKRIREAKKLTQLYVASVVGVTTDTISRWENNRYPTIKRDNAEKVATALEVSLEEILKPEPVSEPEPEPEAVPVLLSPRKQRLAPLVLAVGLGTLLVALIVGAVLSRRGAAELVATRVLPPFGAPGQLVPVQVKVDRRDGEKSGFIVKERIPAGWRFVASNPPVAGEAGEREVKWLIPPGGTGPVTISYTLTAPRTLLLGSQADFGGEVILSHGKATRRGIIGGPARIVVNGRHWADTNGDGRIDDNEIMPAYYLCEEMRGLGLDWKTIETIWSGAGYTWNDKLKVFEVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QY7</accession>
    <name>Q39QY7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, beta-lactamase superfamily II</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3123</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514298.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3123"/>
    <dbReference type="EnsemblBacteria" id="ABB33337">
        <property type="protein sequence ID" value="ABB33337"/>
        <property type="gene ID" value="Gmet_3123"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3123"/>
    <dbReference type="eggNOG" id="COG1237">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036012_0_0_7"/>
    <dbReference type="OMA" id="CSGWRAK"/>
    <dbReference type="OrthoDB" id="1815576at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07713">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041712">
        <property type="entry name" value="DHPS-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="23"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="276" mass="29699" checksum="40497828AE3DA54D" modified="2005-11-22" version="1">MTRRITILCDNTVGPIAGTIGEHGFSALVEWEGGALLFDTGRGEGLLPNAQRMNRDLRRVGTVALSHGHYDHTGGLWGLLSSCGGKEILAHPGIFARRYRVKDTGEALSIGIPYAEEFLRGQGARFSFSDQFREVGSGLFLTGEVPRTAPFERGDTGLFCDDAGCDADPIRDDQSLIVRTERGLVLLLGCCHAGLVNTIEWAREATGVAEIHAVIGGTHLGFCGQNQLDETVAALRGYGVRKILGSHCTGFAAAARLHQEFPGRFHPAHVGYTIEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QZ9</accession>
    <name>Q39QZ9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar motor switch protein FliG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">fliG</name>
        <name evidence="13" type="ordered locus">Gmet_3111</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum basal body</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514286.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3111"/>
    <dbReference type="EnsemblBacteria" id="ABB33325">
        <property type="protein sequence ID" value="ABB33325"/>
        <property type="gene ID" value="Gmet_3111"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3111"/>
    <dbReference type="eggNOG" id="COG1536">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047835_1_1_7"/>
    <dbReference type="OMA" id="QVRPFEF"/>
    <dbReference type="OrthoDB" id="847822at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009425">
        <property type="term" value="C:bacterial-type flagellum basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000090">
        <property type="entry name" value="Flg_Motor_Flig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023087">
        <property type="entry name" value="Flg_Motor_Flig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011002">
        <property type="entry name" value="FliG_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032779">
        <property type="entry name" value="FliG_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028263">
        <property type="entry name" value="FliG_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30534">
        <property type="entry name" value="PTHR30534"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01706">
        <property type="entry name" value="FliG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14841">
        <property type="entry name" value="FliG_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14842">
        <property type="entry name" value="FliG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003161">
        <property type="entry name" value="FliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00954">
        <property type="entry name" value="FLGMOTORFLIG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48029">
        <property type="entry name" value="SSF48029"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00207">
        <property type="entry name" value="fliG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="13" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0283">Flagellar rotation</keyword>
    <keyword evidence="13" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FliG_N" evidence="12">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_M" evidence="11">
        <location>
            <begin position="112"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="FliG_C" evidence="10">
        <location>
            <begin position="214"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB33325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="330" mass="36812" checksum="2B5191267CC4B980" modified="2005-11-22" version="1">MDGTDKAAILLLYLGPDATASVFEHLDDSEIKQISKSMAKLGHVPHSVIQDVVNEFTEMTNPETGIFSQGEEFVRKILEQTLGPQKAEMLLKEISSSSFGDMVDILANLDGKTIANFLSQEHPQTIAVILAKLRAKQTGEIIAMLPQELQAEVVMRIADVDQVSPEILEDIDEVIKRELTAMGGIQRYKVGGVEKVVDMFNYLDRSKEKQILDKLDVLNPPLAEVIRKHLFTFDDIFKLDDRSIQGIMRELSNDTLTLAMKTAPDQIKEKIFRNISSRAAEMIKEDLEVMGPVRLSDVEKAQGEIIKIVRRLEEEGKVVLAGRGGDDVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R57</accession>
    <name>Q39R57_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Serine protease with TPR domains, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513612.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3052"/>
    <dbReference type="EnsemblBacteria" id="ABB33267">
        <property type="protein sequence ID" value="ABB33267"/>
        <property type="gene ID" value="Gmet_3052"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3052"/>
    <dbReference type="eggNOG" id="COG0265">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_361995_0_0_7"/>
    <dbReference type="OrthoDB" id="741829at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009003">
        <property type="entry name" value="Peptidase_S1_PA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001940">
        <property type="entry name" value="Peptidase_S1C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001440">
        <property type="entry name" value="TPR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00834">
        <property type="entry name" value="PROTEASES2C"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50494">
        <property type="entry name" value="SSF50494"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="332"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="424"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="492"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="560"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="772" mass="86290" checksum="B2CAA6D029A31265" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R58</accession>
    <name>Q39R58_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">T5orf172 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513611.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3051"/>
    <dbReference type="EnsemblBacteria" id="ABB33266">
        <property type="protein sequence ID" value="ABB33266"/>
        <property type="gene ID" value="Gmet_3051"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3051"/>
    <dbReference type="eggNOG" id="COG4479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_660155_0_0_7"/>
    <dbReference type="OMA" id="KGEWFAP"/>
    <dbReference type="OrthoDB" id="1361520at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023089">
        <property type="entry name" value="YozE_SAM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036806">
        <property type="entry name" value="YozE_SAM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06855">
        <property type="entry name" value="YozE_SAM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140652">
        <property type="entry name" value="SSF140652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T5orf172" evidence="1">
        <location>
            <begin position="325"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="416" mass="47082" checksum="E0AD87B7712A2C57" modified="2005-11-22" version="1">MPKCTAQEIIKEISEVQSISLPNDWFDNLSDKQSVFSSLYQWMTDSGRVPSDQLTTLHNRTYVGEKTYSKLLTFERKRLAKTLKLRGEKLEEAVAWSDMNSGPKSEIGQSPIAGDVILVIPESSRKALNDFSIRFRNENWLAAVKKVKNHAAGATYYQWLVSQVERPDHIGDTAKDAAIDDTYPRESNDYGELITYLTANVSHAALECFKDGWLEYIQQYPERIKPAAWCDECGQKLNIEDALIAWSKEDQNEVFILDADCRAKFDEFDPMESRPLPGITGADLEELATKVGLSELDIEKLEEKLKLWAVIPASGNSGWVYFIKSESSHEIKIGYTAGPIEKRITSLQTAHSSNLRVLATVPGTREYEKELHRKFADHRLKGEWFAPHHDLVSFIAVLKDNDSRATLVDPTNQTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R59</accession>
    <name>Q39R59_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleic acid-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513610.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3050"/>
    <dbReference type="EnsemblBacteria" id="ABB33265">
        <property type="protein sequence ID" value="ABB33265"/>
        <property type="gene ID" value="Gmet_3050"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3050"/>
    <dbReference type="eggNOG" id="COG1112">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000738_1_0_7"/>
    <dbReference type="OMA" id="AVPVWIM"/>
    <dbReference type="OrthoDB" id="616258at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_11" evidence="2">
        <location>
            <begin position="528"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_12" evidence="3">
        <location>
            <begin position="1290"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1633"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1653"/>
            <end position="1691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1790" mass="201424" checksum="0AD256AF320EEC1D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R61</accession>
    <name>Q39R61_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transposition ATP-binding protein TniB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513608.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3048"/>
    <dbReference type="EnsemblBacteria" id="ABB33263">
        <property type="protein sequence ID" value="ABB33263"/>
        <property type="gene ID" value="Gmet_3048"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3048"/>
    <dbReference type="eggNOG" id="COG2842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067529_2_0_7"/>
    <dbReference type="OMA" id="PQHASRF"/>
    <dbReference type="OrthoDB" id="471286at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008868">
        <property type="entry name" value="TniB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05621">
        <property type="entry name" value="TniB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="303" mass="34573" checksum="45DD47F100A943D9" modified="2005-11-22" version="1">MTIDDKHVARLLPDAREMIGRSLEERIHYIHQDRWLPYPQADRLLSKFEMLLKMPRKIRPPSLLIVGDSHCGKSTLVRRFKDAHPPTDGLYESACPVFYLESCPPEPDEGRLYDEILTTLKVPFRYNDRPDKKLSEVIYQFEQIQVQMIILDEIGHALSGSVLKQRVLLNALKALHNKMHVPIVLVGTMEALYATSSDEQFASRFKAEHLPRWEYGNEFQRFLARLELTLPLSMASLLAAPELSKLVFERTESGCIGDFVDLINEATIMAINGGKEQITAEEIKGCDFTPSSKRQPPAERGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RC3</accession>
    <name>Q39RC3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">ATP-independent chaperone, alpha-crystallin/Hsp20 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hspA-1</name>
        <name evidence="4" type="ordered locus">Gmet_2986</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514477.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2986"/>
    <dbReference type="EnsemblBacteria" id="ABB33201">
        <property type="protein sequence ID" value="ABB33201"/>
        <property type="gene ID" value="Gmet_2986"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2986"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_9_0_7"/>
    <dbReference type="OMA" id="WREPFVD"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="3">
        <location>
            <begin position="35"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="17193" checksum="594A4DA0535F01AB" modified="2005-11-22" version="1">MAIVKYTPFGDLRNLQEQMNRLLDMAWSRESGEELREGVWQPPVDIFEDENGVVIKAELPGIDQKDIEVKIEDNTLTIRGERKHDQEVKKENYHRVERYYGSFMRSFSLPTTIDRDTVKAVCDKGILTITLPRREETKPKQINVEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RL1</accession>
    <name>Q39RL1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33113.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512831.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2895"/>
    <dbReference type="EnsemblBacteria" id="ABB33113">
        <property type="protein sequence ID" value="ABB33113"/>
        <property type="gene ID" value="Gmet_2895"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2895"/>
    <dbReference type="HOGENOM" id="CLU_371222_0_0_7"/>
    <dbReference type="OMA" id="NGYNAIF"/>
    <dbReference type="OrthoDB" id="266292at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223299" evidence="1">
        <location>
            <begin position="26"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33113.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="730" mass="83625" checksum="8A18C2A735CA2A7E" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RT3</accession>
    <name>Q39RT3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Diploptene adenosyltransferase and reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hpnH</name>
        <name evidence="7" type="ordered locus">Gmet_2823</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513981.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2823"/>
    <dbReference type="EnsemblBacteria" id="ABB33041">
        <property type="protein sequence ID" value="ABB33041"/>
        <property type="gene ID" value="Gmet_2823"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2823"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052502_0_0_7"/>
    <dbReference type="OMA" id="FNTDTPQ"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022563">
        <property type="entry name" value="DUF3463"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017833">
        <property type="entry name" value="Hopanoid_synth-assoc_rSAM_HpnH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11946">
        <property type="entry name" value="DUF3463"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00397">
        <property type="entry name" value="adenosyl-hopene_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03470">
        <property type="entry name" value="HpnH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="24"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="332" mass="38366" checksum="80A6ECD87F005DE9" modified="2005-11-22" version="1">MRFPLKLNADLTKYIISNKVKKIEKFPLVLMLEPTHLCNLACSGCGRIREYADTIQQMMSLEECLRSVDECPAPVVTITGGEPFLYSHIYELIPAVLNRGKHVYLCTNGLLLEKALENIKVHPNFYLNVHMDGLEETHDRILERKGTFKIAIEGIKKAKAMGFRVCTNTTIFKDTDLVEIEMLFSLLTDLGVDGILVAPGFDYEAVGENLFLQRREIEKKFEEVYRMSKRFRFWSTPMYLRFLKGEKKLDCTPWGNPTRNPLGWKAPCYLITDTHYPTFREMMEKTDWDKYGVGKDPRCAQCMMHCGFEPTVVSEIGKSWKDILEMAIWNMS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RT4</accession>
    <name>DXS2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-deoxy-D-xylulose-5-phosphate synthase 2</fullName>
            <ecNumber evidence="1">2.2.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-deoxyxylulose-5-phosphate synthase 2</fullName>
            <shortName evidence="1">DXP synthase 2</shortName>
            <shortName evidence="1">DXPS 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dxs2</name>
        <name type="ordered locus">Gmet_2822</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:12605"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
        <text evidence="1">Binds 1 thiamine pyrophosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the transketolase family. DXPS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.7" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513982.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RT4"/>
    <dbReference type="SMR" id="Q39RT4"/>
    <dbReference type="STRING" id="269799.Gmet_2822"/>
    <dbReference type="EnsemblBacteria" id="ABB33040">
        <property type="protein sequence ID" value="ABB33040"/>
        <property type="gene ID" value="Gmet_2822"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2822"/>
    <dbReference type="eggNOG" id="COG1154">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_4_7"/>
    <dbReference type="OMA" id="QVGYHAQ"/>
    <dbReference type="OrthoDB" id="566385at2"/>
    <dbReference type="UniPathway" id="UPA00064">
        <property type="reaction ID" value="UER00091"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008661">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052865">
        <property type="term" value="P:1-deoxy-D-xylulose 5-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02007">
        <property type="entry name" value="TPP_DXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00315">
        <property type="entry name" value="DXP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005477">
        <property type="entry name" value="Dxylulose-5-P_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43322">
        <property type="entry name" value="PTHR43322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13292">
        <property type="entry name" value="DXP_synthase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00204">
        <property type="entry name" value="dxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00801">
        <property type="entry name" value="TRANSKETOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000256423" description="1-deoxy-D-xylulose-5-phosphate synthase 2">
        <location>
            <begin position="1"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="117"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="147"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00315"/>
        </source>
    </evidence>
    <sequence length="635" mass="67995" checksum="90544F82FD31FB30" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RT7</accession>
    <name>Q39RT7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Efflux pump, RND superfamily, and rRNA methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">hpnN</name>
        <name evidence="8" type="ordered locus">Gmet_2819</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513985.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2819"/>
    <dbReference type="EnsemblBacteria" id="ABB33037">
        <property type="protein sequence ID" value="ABB33037"/>
        <property type="gene ID" value="Gmet_2819"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2819"/>
    <dbReference type="eggNOG" id="COG1033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009099_1_0_7"/>
    <dbReference type="OMA" id="AFKIYYV"/>
    <dbReference type="OrthoDB" id="149255at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017841">
        <property type="entry name" value="Hopanoid_biosynth_HpnN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010719">
        <property type="entry name" value="rRNA_methylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06962">
        <property type="entry name" value="rRNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03480">
        <property type="entry name" value="HpnN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="773"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="833"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="864"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="312"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1128" mass="122365" checksum="CDAED38DE33BB8F8" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RZ1</accession>
    <name>Q39RZ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR-related repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32983.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511696.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2765"/>
    <dbReference type="EnsemblBacteria" id="ABB32983">
        <property type="protein sequence ID" value="ABB32983"/>
        <property type="gene ID" value="Gmet_2765"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2765"/>
    <dbReference type="eggNOG" id="COG0790">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1060733_0_0_7"/>
    <dbReference type="OMA" id="ARYMKMA"/>
    <dbReference type="OrthoDB" id="1665559at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223193" evidence="1">
        <location>
            <begin position="29"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32983.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="262" mass="27507" checksum="BA598AF50E5EB555" modified="2012-10-31" version="2">MKGRLTAAGTCSLLAALLLAAPDPSASARVGRNGKTPAAQEFARTRGAAQRGDAGAAFRLALMFLDGTGVARNPAESVRFMRIAAERGHVRAQYFLGTLYHEGAGVKQDQKEAARWIARAAAGGDAEAQYAYGLLLLSGDGVPVDKVAAMEWLGKASRQGSGGARDVLRQLVALPGRPTEIRSLEPFITAPRAAPSGDAADGGAHLEGMGVILDQGEFGLRFSVPHLKEAIAPVYPAYSPDKGVWNRIQGGTFEIIYRPGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S13</accession>
    <name>Q39S13_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2743</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511716.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2743"/>
    <dbReference type="EnsemblBacteria" id="ABB32961">
        <property type="protein sequence ID" value="ABB32961"/>
        <property type="gene ID" value="Gmet_2743"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2743"/>
    <dbReference type="eggNOG" id="COG3055">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_820756_0_0_7"/>
    <dbReference type="OMA" id="TATFTHQ"/>
    <dbReference type="OrthoDB" id="1303819at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014755">
        <property type="entry name" value="Cu-Rt/internalin_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Big_5" evidence="2">
        <location>
            <begin position="36"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="2">
        <location>
            <begin position="139"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Big_5" evidence="2">
        <location>
            <begin position="248"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="352" mass="36632" checksum="B1631D615F85DEEE" modified="2005-11-22" version="1">MKGFIKLFFAAIVLCVLVVGCGSGGGGGGVTAIDLIRPEISQTLPANGATNVGTTSPIIITFSEPMNQDSVKAAFSLATGSTTIPCTFSYNGTTATFTPPALNGNTPYTATIAATAKDMAGNSLGGDHAWTFTTGIGQDTTPPTVQSYAPTGTAVGINSTIAITFSEPMNTDSVKAAFSLTPTADPTKKISGTFSFIGDTAVFTPDTLLDYYTSYTVTIATTATDLVGNNMTALPPWNFTTRPPPAKDTEAPIVSPGLEFPLDGSTDVPRNTPISVSFNEPIAPFYYGSINGFPTKVTIDYTTNTVTMKPTTLLTANTTYTVSIRVTDLAGNSMATTYQWQFTTGATPTSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S46</accession>
    <name>Q39S46_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">cheAY40H-2</name>
        <name evidence="10" type="ordered locus">Gmet_2710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2710"/>
    <dbReference type="EnsemblBacteria" id="ABB32928">
        <property type="protein sequence ID" value="ABB32928"/>
        <property type="gene ID" value="Gmet_2710"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2710"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_2_1_7"/>
    <dbReference type="OMA" id="QLEACMR"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="9">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="296"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="8">
        <location>
            <begin position="502"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="660"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="777" mass="84808" checksum="23B54867984DFA2E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SB5</accession>
    <name>Q39SB5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein glutamate methylesterase CheB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheB-7</name>
        <name evidence="3" type="ordered locus">Gmet_2640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511821.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2640"/>
    <dbReference type="EnsemblBacteria" id="ABB32859">
        <property type="protein sequence ID" value="ABB32859"/>
        <property type="gene ID" value="Gmet_2640"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2640"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_2_7"/>
    <dbReference type="OMA" id="PGYHLSV"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="2">
        <location>
            <begin position="10"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="194" mass="19987" checksum="A15550A17FCB8C7B" modified="2005-11-22" version="1">MDRNSQHRFRAVVVGVSSGGVDALKQVIGSLPAGFPLPVLVVAHISPEADNGLALLLDELSAIRVKEADELEKAAAGTVYLAPPNYHLLVEKDATLSLSVDPPVRFARPSVDVLFGSAADAFGPALIGVVMTGAGCDGSWGLGRIKDAGGVTVVQDPADAVADSMPRSAVEAVGPDHIVPLERIAPLLVRLATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SF4</accession>
    <name>Q39SF4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ech-hydrogenase-related complex, NuoL-like integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ehrA-1</name>
        <name evidence="4" type="ordered locus">Gmet_2601</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511860.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2601"/>
    <dbReference type="EnsemblBacteria" id="ABB32820">
        <property type="protein sequence ID" value="ABB32820"/>
        <property type="gene ID" value="Gmet_2601"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2601"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_8_1_7"/>
    <dbReference type="OMA" id="PPLWWGV"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003918">
        <property type="entry name" value="NADH_UbQ_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01437">
        <property type="entry name" value="NUOXDRDTASE4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="425"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="641"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="135"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="660" mass="70160" checksum="3CB2A746C0199CBD" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SG3</accession>
    <name>Q39SG3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin, HicA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2592</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2592"/>
    <dbReference type="EnsemblBacteria" id="ABB32811">
        <property type="protein sequence ID" value="ABB32811"/>
        <property type="gene ID" value="Gmet_2592"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2592"/>
    <dbReference type="eggNOG" id="ENOG5032SSN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_164851_0_0_7"/>
    <dbReference type="OMA" id="NIHSPHP"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012933">
        <property type="entry name" value="HicA_mRNA_interferase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07927">
        <property type="entry name" value="HicA_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="89" mass="10113" checksum="596348827ED291BD" modified="2005-11-22" version="1">MVLKLMKRKNLKTLESIFAHPVPGNVQWPDILALFKELGAEITEREGSRVGVRLFGDRRVFHRPHPSPDTDKGAVASIRKWLEENGVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SH6</accession>
    <name>Q39SH6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2579</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513455.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2579"/>
    <dbReference type="EnsemblBacteria" id="ABB32798">
        <property type="protein sequence ID" value="ABB32798"/>
        <property type="gene ID" value="Gmet_2579"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2579"/>
    <dbReference type="eggNOG" id="ENOG5031WQ8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_136707_2_0_7"/>
    <dbReference type="OMA" id="CFGESEY"/>
    <dbReference type="OrthoDB" id="1860536at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="124" mass="13828" checksum="533EE43EE02B515A" modified="2005-11-22" version="1">MPITKGKVFGGIAGIVVLVLVAIAGYTWFSLTWTYSTGERAGYVQKFSKKGWVFKTWEGELQMLPVPGAIPEKFAFSVRDDAIAQQINAAVGKKVVLHYGQHKWVPSTIFAETEYFVEEVKVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SM3</accession>
    <name>Q39SM3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc-dependent peptidase, M16 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2530</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase M16 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2530"/>
    <dbReference type="EnsemblBacteria" id="ABB32751">
        <property type="protein sequence ID" value="ABB32751"/>
        <property type="gene ID" value="Gmet_2530"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2530"/>
    <dbReference type="eggNOG" id="COG0612">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009902_1_0_7"/>
    <dbReference type="OMA" id="YDVGSRH"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="SSF63411"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223349" evidence="4">
        <location>
            <begin position="24"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="5">
        <location>
            <begin position="43"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16" evidence="5">
        <location>
            <begin position="145"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M16_C" evidence="6">
        <location>
            <begin position="248"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="496" mass="56351" checksum="D7172C1D87391C57" modified="2005-11-22" version="1">MLMKTVRFVVCFMVMLFSLPAFGAGLEERVREHTLRNGMKLLMVERHTSPTVAAWIRFRVGSVDERSDERGLAHLLEHMLFKGTKTLGTKDYAAEKPLLDKIEATALPLVAEKAKGDKADPARVAELQKKLNELEAEAAKYVIKEEFAEIYARNGGTGYNAFTSKDGTTYLINMPANKLELWAAIESDRMQNAVLREFYTERDVVMEERRRSYDTEPGSKLWENFVASSYHAHPFGQPTIGWMSDIENLTRTKAEEFLTRYYKPNNAIVAVVGDIDPEKTIALVEKYFSTIPLGTPVPPVAVVEPRQEGERRVEIIADSEPELLMGFHKPSLPAADDYVFDVIDMVLADGRTSRLYKKLIVEKQLATEVSSFSAPGNRYPNLFVIAATTRAPHTVAEVEASVYEELERLKKEPITERELQQILNKLEYEESRQMLSNGGLARNLTEYEAVAGTWRYLIEHRSKVAKVTPDDVIRVARKYFTRENRIVGFITKKTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SS9</accession>
    <name>Q39SS9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2470"/>
    <dbReference type="EnsemblBacteria" id="ABB32695">
        <property type="protein sequence ID" value="ABB32695"/>
        <property type="gene ID" value="Gmet_2470"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2470"/>
    <dbReference type="eggNOG" id="COG3880">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_241757_0_0_7"/>
    <dbReference type="OMA" id="CHSGTIG"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010176">
        <property type="entry name" value="C4xCH_C2xCH_motif_GEOSU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09698">
        <property type="entry name" value="GSu_C4xC__C2xCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01904">
        <property type="entry name" value="GSu_C4xC__C2xCH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223076" evidence="2">
        <location>
            <begin position="31"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="3">
        <location>
            <begin position="907"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1481"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1506"/>
            <end position="1521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1521" mass="163517" checksum="246F52649D495AA9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SY4</accession>
    <name>Q39SY4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hpnK</name>
        <name evidence="5" type="ordered locus">Gmet_2415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512485.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2415"/>
    <dbReference type="EnsemblBacteria" id="ABB32640">
        <property type="protein sequence ID" value="ABB32640"/>
        <property type="gene ID" value="Gmet_2415"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2415"/>
    <dbReference type="eggNOG" id="COG3394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064244_2_0_7"/>
    <dbReference type="OMA" id="DFELGCH"/>
    <dbReference type="OrthoDB" id="1204930at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017836">
        <property type="entry name" value="Hopanoid_biosynth-assoc_HpnK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006879">
        <property type="entry name" value="YdjC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31609">
        <property type="entry name" value="PTHR31609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04794">
        <property type="entry name" value="YdjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03473">
        <property type="entry name" value="HpnK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="288" mass="32281" checksum="AC5EFAFEE4874F41" modified="2005-11-22" version="1">MKELIINADDFGLSDGVNKAVIKAWQEGILTSASLMVGADAFHEAVHLAKANPGLQVGLHLTLVQGRAVGEHPKFPRICDAKGLFTDDPVHAGMRYYFIKPFRKQLHREIEAQIEGFLQTGIPLSHIDGHLNIHMHPVVFDILCELMPKYGITTFRLSRENLRSNLAIDRSRLFGKATDAFIFSKLANRCRPVLDRFGIGYTGEVKGLLSSGRMTESYLLKALETLEEGTTEIYFHPGCLPCTEITRRMPDYRHEEELAALTSSRVKGRLKELGIGLKNYRGEVKTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T04</accession>
    <name>Q39T04_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Succinate dehydrogenase/fumarate reductase, iron-sulfur protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">frdB</name>
        <name evidence="9" type="ordered locus">Gmet_2395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2395"/>
    <dbReference type="EnsemblBacteria" id="ABB32620">
        <property type="protein sequence ID" value="ABB32620"/>
        <property type="gene ID" value="Gmet_2395"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2395"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044838_3_3_7"/>
    <dbReference type="OMA" id="CPKGISL"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="SSF54292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="8">
        <location>
            <begin position="156"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="251" mass="27235" checksum="58797B990DC79581" modified="2005-11-22" version="1">MSHDNTMNLTLHVWRQNGPKDPGKFEVYEAKNVSPDQSFLEMLDEVNEDLIKAGKDPIAFDHDCREGICGMCSQVINGAPHGGQDRTTVCQLHMRMFKDGDTIYIEPWRARAFPIVKDLVVDRAALDTIIQAGGYTSAHTGGVADGNALLVPKDIADYAMDAAECIGCGACVAGCPNGSAMLFTSAKVSQLAVLPQGKAEAKRRVQEMTGALQECGFGNCTNHYECQAACPKGINVKFIATLNREYLKSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T57</accession>
    <name>Q39T57_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2342</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366041.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2342"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32567">
        <property type="protein sequence ID" value="ABB32567"/>
        <property type="gene ID" value="Gmet_2342"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2342"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_948903_0_0_7"/>
    <dbReference type="OMA" id="EHEILVH"/>
    <dbReference type="OrthoDB" id="957193at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="270" mass="31273" checksum="F5B5BC03818A03A5" modified="2005-11-22" version="1">MISIVIPLYNQVAYTQLCVQSLRRAGLNGVDVLLIDNGSTDGTAEYLKSCSDLRVIRNRENLGCAGAWNQGVRETTSEWVMILNNDVVVSPGWLDGLLEAAGKEGLDVVSPAIREGEYNYDIEGYSQEFVGRMGDVVRRGVADGICFMVRRRVFEVVGLFDENFRIGQFEDADFFRRARNAGFRLGTTGRSFIHHFGSVTQDAIRKNRPERPYVAENRAYFREKWQLTRGRRLIERWRRKLREFAWQKCERMFHGHTLKEKWLGGRLRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T62</accession>
    <name>Q39T62_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ALGX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2337</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; alginate biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513283.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2337"/>
    <dbReference type="EnsemblBacteria" id="ABB32562">
        <property type="protein sequence ID" value="ABB32562"/>
        <property type="gene ID" value="Gmet_2337"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2337"/>
    <dbReference type="eggNOG" id="ENOG502ZBWK">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801138_0_0_7"/>
    <dbReference type="OMA" id="WCRIFLA"/>
    <dbReference type="OrthoDB" id="1834379at2"/>
    <dbReference type="UniPathway" id="UPA00286"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031811">
        <property type="entry name" value="ALGX/ALGJ_SGNH-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16822">
        <property type="entry name" value="ALGX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0016">Alginate biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ALGX" evidence="4">
        <location>
            <begin position="238"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="346" mass="39863" checksum="DF75D922CE3E8953" modified="2005-11-22" version="1">MKYKRWCRIFLAVVALFIGLNFLLWEVVTEDLLTDKHYAGGDLARMGYLARVKVPRTNHVDLPKRHLEVSDYAGQKIDVLTIGDSFSQGAAGGRNRYYQDYMASLSGVSVLNVGQYRGIDSITTVSIWCNNGYLDRLKPRYVLIEAAEKFSFDEFAQPIDFSRILSEEQLKGYRAKGGAGQMPEVSFINTGNFKFILYNLLYPISDHAFVGKVHVRHLKGDLFTTAEPSTLLFLKYKKFATADQIEALNRNLNTLSDKLAQKGIRLCFMPVVDKYNLYSEFIVDNPYPTSDFFEKLRPLPKRYIFVDTKKVLLDEVRRGEKDVFYADDTHWNWKASEAIFSRQLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TB4</accession>
    <name>Q39TB4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytidine-specific tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ccaC</name>
        <name evidence="6" type="ordered locus">Gmet_2285</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514513.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2285"/>
    <dbReference type="EnsemblBacteria" id="ABB32510">
        <property type="protein sequence ID" value="ABB32510"/>
        <property type="gene ID" value="Gmet_2285"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2285"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_6_0_7"/>
    <dbReference type="OMA" id="FATRYAY"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PolyA_pol" evidence="4">
        <location>
            <begin position="28"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="PolyA_pol_RNAbd" evidence="5">
        <location>
            <begin position="168"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="431" mass="46600" checksum="0CA6D86EE70F696F" modified="2005-11-22" version="1">MDASIASFLQNPFLRTLRQASASLDLQCYVVGGCLRDLLMGRGVNDVDIAVGGGPEALSRRFAKECGGTFFWLDQERGHSRVVIKGGAGIDTFDFAPLRGEDICADLALRDFTINSLAVPLQGGVELFDPLKGETDIRAQLVRRCAESVFRDDPLRLVRAFRFAATLGFRIETETLAAITTHAPLIANSAGERIRDELFQVLCMPGTGSVFRTMGDAGLLCVLFGLSPSQVYPAAEAMDRVEAVVQSLSQLGDETAEKGCLRLQEQIQGGMTVLSLTKLAAFLTVTEADLPAAADRLKLGKTAGQLVEKLCRADTLALAERLDTVSAYTLFNACDPAGLELPLLLLARGHITESRCRELARYYLHCHIPRGGNLLLSGAEIMELLSVPPCKMVGDAHELLREAQCTGQVRTGAEASVFLRKKLLTTNEPMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TH8</accession>
    <name>Q39TH8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2219</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenine + H(+) + H2O = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32446.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2219"/>
    <dbReference type="EnsemblBacteria" id="ABB32446">
        <property type="protein sequence ID" value="ABB32446"/>
        <property type="gene ID" value="Gmet_2219"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2219"/>
    <dbReference type="eggNOG" id="COG1001">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1269296_0_0_7"/>
    <dbReference type="OMA" id="IEGHFPG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="PTHR11113:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="5">
        <location>
            <begin position="83"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine_deam_C" evidence="6">
        <location>
            <begin position="426"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32446.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="598" mass="64638" checksum="0AD854D4162CA36F" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TK1</accession>
    <name>Q39TK1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2196</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365952.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2196"/>
    <dbReference type="EnsemblBacteria" id="ABB32423">
        <property type="protein sequence ID" value="ABB32423"/>
        <property type="gene ID" value="Gmet_2196"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2196"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_996622_0_0_7"/>
    <dbReference type="OrthoDB" id="977512at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="279" mass="29504" checksum="6F75FA3D1A614D96" modified="2005-11-22" version="1">MSAYRYERDGEGIVTVTINPAGQPASIMDEGTAGELLDRLERDTISGVIITIDQASPATACTVSENSLSARQQVFNRLSAYKSMLRRLETLGKPVVAAINGPTQGRDYELCLAAHHRIAVNDLAIAIGLPDVAAGLIPCNGGVARLVRLIGLEKGLPLLMAGTKLAPEKAKETGLIDQLAASSGELQSMARDWIAANPAAGQPWDQKGYKMPGGTPSSPNIAQQIFVAPAILRKKCADGQPAQESILAVAVEGAQVDLESALRIESRYFTDLLFRTAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TQ0</accession>
    <name>Q39TQ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bamW</name>
        <name evidence="8" type="ordered locus">Gmet_2145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513060.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39TQ0"/>
    <dbReference type="STRING" id="269799.Gmet_2145"/>
    <dbReference type="EnsemblBacteria" id="ABB32374">
        <property type="protein sequence ID" value="ABB32374"/>
        <property type="gene ID" value="Gmet_2145"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2145"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="HASHILK"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="3"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="142"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="446" mass="50022" checksum="D6D9DE72861C5DFF" modified="2005-11-22" version="1">MRTILVADDDRAIRRTLELHLAETGYTVLTAATGNEAVDLALARDVGLVLLDLRLTGMDGFEVLTLIKERKPALPVIMITAYDDMQTAIEAIRLGAIDHLGKPLDLDQLDQIIDKIFEMSALSRTGVAFRDSIDAPFEQNIMVGRSRAMKEVYKTIGAIADFRATVLIQGESGTGKEMVARAIHFNSKFRNRPFIAVACSALSPTVLESELFGHEKGAFTGAYRTKPGKFELAQGGTLFLDEISEISPELQVKLLRFIQEREFERVGGIETIKADVRIVAATNKNLLTLVNSGIFRHDLYYRLKVVSIDLPPLRERRDDIPILVKFLLEKLHHETGKRVDIIPQETMNAILAHPWAGNVRELENTLRRAVLLSHGSVLSPESLHLEEESESDSFPLVLRPLHEVEREHIQNVLAFTHNEKKRAAEILGISRPTLDRRIKEYGLEDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U04</accession>
    <name>Q39U04_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2041</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512910.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2041"/>
    <dbReference type="CAZy" id="GT1">
        <property type="family name" value="Glycosyltransferase Family 1"/>
    </dbReference>
    <dbReference type="DNASU" id="3739821"/>
    <dbReference type="EnsemblBacteria" id="ABB32270">
        <property type="protein sequence ID" value="ABB32270"/>
        <property type="gene ID" value="Gmet_2041"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2041"/>
    <dbReference type="eggNOG" id="COG0707">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1819">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_692271_0_0_7"/>
    <dbReference type="OMA" id="THTEREY"/>
    <dbReference type="OrthoDB" id="1485440at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="289"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="406" mass="45210" checksum="9C2D34745ABEEB6C" modified="2005-11-22" version="1">MRILAFPYTHTLSHLSRVLAVALELRRMGHEVVFAGESAKVSFVSQQGFDVVPIHEPDPEMLFGNIRSGKLRFVEDAELLQMLTADIEVIRSLKPDLVLSDGRFSAPLSTHLTNVRHAAIVNASSTEYRALPYVPFFDWMPPWLISRDAMIWKALVRLNLFLEMKLFDNVMKVFKRLSRELNTNRTVTATNCLTGKDITLLADIPEYFPSRNLPASYHYVGPLTWKSVLAPPAWWPLDIPSSPLVYVTMGTTGVSEFFSKLGPSLSTSFFSSIVTTGGQSSELKPMPGKVYVESYLDGDLVMERSDVVICHGGNGTIYQALSHGKPVIGIPTIPDQKFNMRRVEAMGFGKSLDLKQFLEKPSLLADTVKQVLSDHSFRNSAQKIQAVLKSYNAATTSAKILIDSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U14</accession>
    <name>Q39U14_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Undecaprenyl-phosphate glycosylphosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2031</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial sugar transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365906.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2031"/>
    <dbReference type="DNASU" id="3739811"/>
    <dbReference type="EnsemblBacteria" id="ABB32260">
        <property type="protein sequence ID" value="ABB32260"/>
        <property type="gene ID" value="Gmet_2031"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2031"/>
    <dbReference type="eggNOG" id="COG2148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024920_0_0_7"/>
    <dbReference type="OMA" id="INYPYGA"/>
    <dbReference type="OrthoDB" id="1759731at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003362">
        <property type="entry name" value="Bact_transf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017475">
        <property type="entry name" value="EPS_sugar_tfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017464">
        <property type="entry name" value="Sugar_tfrase_EpsB_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02397">
        <property type="entry name" value="Bac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03025">
        <property type="entry name" value="EPS_sugtrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03013">
        <property type="entry name" value="EpsB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="5"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Bac_transf" evidence="8">
        <location>
            <begin position="265"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="454" mass="50684" checksum="5B2317F4C59F014C" modified="2005-11-22" version="1">MKKMVILLITGDIVCTVLALGIAYLVRFGTIPGMESFLSLAGAVQLVLLVLAVIFSSFMVEFYNVDKDMKLRERIAHSAISLSVSFLILSAIFYLAPDLTIGRGLLAMALVIWGSLQILWHLFCRVSLYHPGLARRVLVLGTGPLAREIGGLVSATNHNHVLAGYFSCPNEPVYVPSQHIVGNGDGLVSAAIRERTDKIVVSLSERRGSFPLSEVLSCKFSGIEVVDAPSFYEQITGKLMIENITPSWFIFSNGFRRTGFGRIMKRSTDLVLSLVGIILVLPILPFIALGIRITSPGQILFRQVRVGQGDRPFVLYKFRSMRADAEKSSGAVWAQKDDPRVTRFGKFLRTSRLDELPQLYNVLRGDMSLVGPRPERPEFVEKLKEVIPYYSERHFVKPGVTGWAQVKYPYGASVDDAIEKLRYDLYYIKNMSMLLDIIIVLETIKVVLFGRGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U39</accession>
    <name>Q39U39_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Cysteine desulfurase</fullName>
            <ecNumber evidence="4 7">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">sufS</name>
        <name evidence="9" type="ordered locus">Gmet_2006</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>[sulfur carrier]-H + L-cysteine = [sulfur carrier]-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="4 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512944.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2006"/>
    <dbReference type="EnsemblBacteria" id="ABB32235">
        <property type="protein sequence ID" value="ABB32235"/>
        <property type="gene ID" value="Gmet_2006"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2006"/>
    <dbReference type="eggNOG" id="COG0520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003433_2_5_7"/>
    <dbReference type="OMA" id="HKLCGPT"/>
    <dbReference type="OrthoDB" id="446447at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006534">
        <property type="term" value="P:cysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06453">
        <property type="entry name" value="SufS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010970">
        <property type="entry name" value="Cys_dSase_SufS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01979">
        <property type="entry name" value="sufS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_5" evidence="8">
        <location>
            <begin position="23"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="395" mass="43754" checksum="88E5B5C4044C3223" modified="2005-11-22" version="1">MDIQKIRGDFPIFERRINGKPIVYFDSAATTQKPRQVIDTLSNYYANHCANIHRGVHTLSQESSELYEEARRTVARFINADEREIVFVRNTTEAINLVSTCLKGEGQILSTVTEHHSNLLPWGRSRKVDYVDIDAQGRIDVADLKEKLLKPTLLVAVTHVSNVLGLVNPVEEVIAEARKNGALTLVDAAQSAPHMEIDVKAMGCDFLVFSGHKMLAPSGIGVLYVREELYERMEPYLMGGSTIKEAHLGSYVPEEPPTCYEAGTPNIEGAIALASAIDYLNDIGMDNVLAHDKALMALALERMKAIDNVELYGSLDPTDRLSVITFNVKGMGCHGVAKVLNLRENIMIRSGFHCAQPLHDRLGIGPTARMSFYIYNTPEEIELAAELLGKIAEFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U43</accession>
    <name>Q39U43_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Exopolysaccharide synthesis periplasmic protein I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">epsI</name>
        <name evidence="3" type="ordered locus">Gmet_2002</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512948.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2002"/>
    <dbReference type="EnsemblBacteria" id="ABB32231">
        <property type="protein sequence ID" value="ABB32231"/>
        <property type="gene ID" value="Gmet_2002"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2002"/>
    <dbReference type="HOGENOM" id="CLU_1324808_0_0_7"/>
    <dbReference type="OrthoDB" id="1863187at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014263">
        <property type="entry name" value="Methanolan_biosynth_EpsI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11984">
        <property type="entry name" value="DUF3485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02914">
        <property type="entry name" value="EpsI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223125" evidence="1">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3485" evidence="2">
        <location>
            <begin position="5"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="207" mass="23583" checksum="DC2C2BBD60C95058" modified="2005-11-22" version="1">MRAITLLLLLLATSGFVFLDNHLANKPVTVKLEDFPFTVGEWRGTPYTVEDRVKDILETEYILSRDYSSPQGEHVYLSLVYYPDNKIGFHNPESCNTGVGMKVLDERIVPITVTLAGGKQEQIDLNRLVLGYAEPVRVIYYFYLSGDRMTGKYSTFRWEMLQQQMQFKRPSGAQVQLHVPVRGSVDATRDVATRYMNSLAPALTSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U72</accession>
    <name>Q39U72_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Endonuclease III-related DNA glycosidase, HhH-GPD superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nth/MutY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511871.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1973"/>
    <dbReference type="EnsemblBacteria" id="ABB32202">
        <property type="protein sequence ID" value="ABB32202"/>
        <property type="gene ID" value="Gmet_1973"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1973"/>
    <dbReference type="eggNOG" id="COG0177">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_3_4_7"/>
    <dbReference type="OMA" id="WQQFTHL"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="3">
        <location>
            <begin position="44"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="218" mass="24207" checksum="7BB069EBEBAE135D" modified="2005-11-22" version="1">MKDSDIHEAMALLAEAVKSWPSPAVTIVSQREGNPFKVLVSCILSLRTQDRTTGPASERLFGLADTPAKMLFLSSDAIEQAIYPVGFYRNKAAQILDICRTLVDKYDGQVPDDLDELLTFRGVGRKTANLVLTLGFGKLAICVDTHVHRICNRWGYTSTKTPAETEFALRAKLPQKYWPVINDYLVTFGQNQCTPVSPRCSTCVLVCFCDRVGVTKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UC1</accession>
    <name>Q39UC1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Menaquinol oxidoreductase complex Cbc3, cytochrome c subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cbcX</name>
        <name evidence="9" type="ordered locus">Gmet_1924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511919.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1924"/>
    <dbReference type="EnsemblBacteria" id="ABB32153">
        <property type="protein sequence ID" value="ABB32153"/>
        <property type="gene ID" value="Gmet_1924"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1924"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1044934_0_0_7"/>
    <dbReference type="OMA" id="FHEVNTA"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012286">
        <property type="entry name" value="Tetrahaem_cytochrome"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14537">
        <property type="entry name" value="Cytochrom_c3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223137" evidence="7">
        <location>
            <begin position="29"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_c3_2" evidence="8">
        <location>
            <begin position="58"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="270" mass="29381" checksum="7EBD5F177C50ABFD" modified="2005-11-22" version="1">MRLSATYSSSALICLPLLLLLSLFPADARCQEQTVCLQCHGAQTGKGGAPVKAWRGSVHADNGISCNDCHGGDPRDAANAMSPVRGFLGVPGETGIPAFCGRCHVGIREEYLKSAHGRALGKGGPTCVTCHGSHTVMKATLDLINDKNCSRCHPYDRASVIKEAMRQTDGSITDIARKIQQFKGEGINIEVQEKSLFDLRNRYHRLFHVVDVGRVKQESEVIRQGLGTIEQALAKLDERNKRRKIVGTTVVAGLLLATLLSYLLKKTFDN</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-03" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UC4</accession>
    <name>F16PA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fructose-1,6-bisphosphatase class 1</fullName>
            <shortName evidence="1">FBPase class 1</shortName>
            <ecNumber evidence="1">3.1.3.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fbp</name>
        <name type="ordered locus">Gmet_1921</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 1,6-bisphosphate + H2O = beta-D-fructose 6-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:11064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="3.1.3.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FBPase class 1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511922.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UC4"/>
    <dbReference type="SMR" id="Q39UC4"/>
    <dbReference type="STRING" id="269799.Gmet_1921"/>
    <dbReference type="EnsemblBacteria" id="ABB32150">
        <property type="protein sequence ID" value="ABB32150"/>
        <property type="gene ID" value="Gmet_1921"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1921"/>
    <dbReference type="eggNOG" id="COG0158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039977_1_0_7"/>
    <dbReference type="OMA" id="YIPENCP"/>
    <dbReference type="OrthoDB" id="945770at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042132">
        <property type="term" value="F:fructose 1,6-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00354">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01855">
        <property type="entry name" value="FBPase_class1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044015">
        <property type="entry name" value="FBPase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000146">
        <property type="entry name" value="FBPase_class-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033391">
        <property type="entry name" value="FBPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028343">
        <property type="entry name" value="FBPtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023079">
        <property type="entry name" value="SBPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11556">
        <property type="entry name" value="PTHR11556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00316">
        <property type="entry name" value="FBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18913">
        <property type="entry name" value="FBPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500210">
        <property type="entry name" value="FBPtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000904">
        <property type="entry name" value="FBPtase_SBPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01958">
        <property type="entry name" value="S17BPHPHTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000364559" description="Fructose-1,6-bisphosphatase class 1">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01855"/>
        </source>
    </evidence>
    <sequence length="314" mass="34634" checksum="923437071755574C" modified="2005-11-22" version="1">MPFSEPGKTKFQVDLRRHLRNQGICDNLVHLICEIAEASKYVINAVRTGDLGVAGTSNLYGEEQLALDVLSDRIIKKRLIHSGVVCNIASEEMDEIFQAQADADGLYSVAYDPLDGSSLVDVNLAVGTIVSIYEGCNLLQKGRNQVAALYILYGPRVSMVYSVGRGVHEFTMNHLMEFTLSRENIVMQEEGNIYAPGGLRNKYQEGTEQFVRYLEEKGAKLRYSGGFVPDINQVIMKGKGIFMYPALNGSPNGKLRLLFELNAMAYLVENAGGAATDGKQPILDLEPHSLDQRAPVYIGCKADVVKAMEFVSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UE6</accession>
    <name>Q39UE6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511945.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1899"/>
    <dbReference type="EnsemblBacteria" id="ABB32128">
        <property type="protein sequence ID" value="ABB32128"/>
        <property type="gene ID" value="Gmet_1899"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1899"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="YSLFPWR"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="264" mass="29319" checksum="6C66F2EB3B5FB19D" modified="2005-11-22" version="1">MSRPVKINLQGVEKRFPASGGKEITALQRLDLEIGAGEFICLVGPSGCGKTTLINLMAGFDRPSSGSITIDGQPVTGPDPDHIMIFQDYGLFPWRTVLGNVLFALQSRGVGKKEAQERATEYLKLVGLSSFLQSFPHQLSGGMKQRVAIARALAVEPSVLFMDEPFAALDAFTRLRLQDEVLRLWEEKRPTVIFVTHDLDEAIYLGGRVILMAPDPGRVSKILPVYLPRPCDRTSEEFATYRRELFEEFHLVHREAAGEAAYSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UJ1</accession>
    <name>Q39UJ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc metalloendopeptidase M23 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1854</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511992.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1854"/>
    <dbReference type="EnsemblBacteria" id="ABB32083">
        <property type="protein sequence ID" value="ABB32083"/>
        <property type="gene ID" value="Gmet_1854"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1854"/>
    <dbReference type="eggNOG" id="COG4942">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029425_4_0_7"/>
    <dbReference type="OMA" id="SDPAQWC"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223285" evidence="2">
        <location>
            <begin position="23"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="296"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="394" mass="44015" checksum="8BF1A348BEDD9159" modified="2005-11-22" version="1">MRWLQSITALLVVLLTAAAADADVRDQLQGVKKEIKEKKQLLKKTTKVEQQVSGELQAIDRNLKQKEAQFASLARELQGVERTISKTETEINTVRNEVEQKKHEIERRLVAVYKAGEIGNVRVFYSSESFPQMVENLRYMRSVIDNDRKLFADYNKKIAELSKLKVVLENDANRKERLKIGIEQKKQEIAGEKSNKAAYLVKVRQDKQAHLASLRELQANAGRLQAMVRKLEAMSRKSYTSAARKPSAKGMSPVLPPISDKGFGAQRGRLSLPVSGKIVSGFGRHKHPEFNSYTVSNGVSIAAPSGADIKAVYEGKVIFANYFKGYGNMVIVDHGGGFFSLYAHASRIAKRVGAEVARNETIASVGDVDSPRGDMLYFEIRYQGRPVDPASWCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UL7</accession>
    <name>Q39UL7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PppGpp 5'-phosphohydrolase and exopolyphosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">gppA-1</name>
        <name evidence="2" type="ordered locus">Gmet_1828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512017.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1828"/>
    <dbReference type="EnsemblBacteria" id="ABB32057">
        <property type="protein sequence ID" value="ABB32057"/>
        <property type="gene ID" value="Gmet_1828"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1828"/>
    <dbReference type="eggNOG" id="COG0248">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025908_1_2_7"/>
    <dbReference type="OMA" id="IGCVRMT"/>
    <dbReference type="OrthoDB" id="1862004at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003695">
        <property type="entry name" value="Ppx_GppA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02541">
        <property type="entry name" value="Ppx-GppA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ppx-GppA" evidence="1">
        <location>
            <begin position="20"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="304" mass="32478" checksum="8CF8FCA4466E3637" modified="2005-11-22" version="1">MHDVLASIDLGTNTARLLIGKVEGGAVAPILVKRRITRLGGGFTREAGISPEAWQRSLDALIDFAAEMKRGGVTRLRAVATSAVRDAVNGAAFCSEVTERTGIRLEVIDGEEEGLLTLAGVISGLNRKEGDFFVFDVGGGSTEYTLAESRRPLHTESLPLGVVRLTEGKPDVPAMEEKIGRELAGLGKSLEGEGLRGRLDGATLVGTAGTATTLAAISLQMTDYDYRRVNNHVITRDEIGRIFTMLLPLSSEERLTVPGLEKGREDLIIAGILITLKTMDVFGFDRMTVSDFGLLEGVLLGLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UP3</accession>
    <name>Q39UP3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Benzoyl-CoA reductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">bamB-2</name>
        <name evidence="9" type="ordered locus">Gmet_1802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AOR/FOR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512044.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1802"/>
    <dbReference type="EnsemblBacteria" id="ABB32031">
        <property type="protein sequence ID" value="ABB32031"/>
        <property type="gene ID" value="Gmet_1802"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1802"/>
    <dbReference type="eggNOG" id="COG2414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020364_1_0_7"/>
    <dbReference type="OMA" id="IVDWMEM"/>
    <dbReference type="OrthoDB" id="332680at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016625">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.569.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.599.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.9.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013984">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013985">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013983">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036503">
        <property type="entry name" value="Ald_Fedxn_OxRdtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001203">
        <property type="entry name" value="OxRdtase_Ald_Fedxn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036021">
        <property type="entry name" value="Tungsten_al_ferr_oxy-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01314">
        <property type="entry name" value="AFOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02730">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00790">
        <property type="entry name" value="AFOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48310">
        <property type="entry name" value="SSF48310"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56228">
        <property type="entry name" value="SSF56228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AFOR_N" evidence="8">
        <location>
            <begin position="6"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="656" mass="74627" checksum="B849EF5FEE29DDFC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UQ0</accession>
    <name>Q39UQ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SEFIR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512053.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1793"/>
    <dbReference type="EnsemblBacteria" id="ABB32024">
        <property type="protein sequence ID" value="ABB32024"/>
        <property type="gene ID" value="Gmet_1793"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1793"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1672">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_276679_0_0_7"/>
    <dbReference type="OrthoDB" id="300983at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013568">
        <property type="entry name" value="SEFIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08357">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51534">
        <property type="entry name" value="SEFIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEFIR" evidence="2">
        <location>
            <begin position="3"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1149" mass="129816" checksum="1A7C09BF0A8C26F2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UT3</accession>
    <name>Q39UT3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513344.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1760"/>
    <dbReference type="EnsemblBacteria" id="ABB31991">
        <property type="protein sequence ID" value="ABB31991"/>
        <property type="gene ID" value="Gmet_1760"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1760"/>
    <dbReference type="eggNOG" id="COG0742">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075826_0_2_7"/>
    <dbReference type="OMA" id="FNWLMPY"/>
    <dbReference type="OrthoDB" id="1827334at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004398">
        <property type="entry name" value="RNA_MeTrfase_RsmD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004553">
        <property type="entry name" value="CHP00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00095">
        <property type="entry name" value="TIGR00095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="188" mass="20509" checksum="15E4BA1A7E5A04BC" modified="2005-11-22" version="1">MRVIGGTARGRRLAAPRGERVRPTADRVKEALFSILTSLLGNLEGLRVLDVFAGTGNLGIEALSRGCSEAIFVDSHRESAAIIRQNLTQLNLTDRGRVIVKDAASALQCLNENIAPFTIIFLDPPYRQGLAEKVLGILASAPFVTRETIIVSESDSSEVFPERFGALQQFDRRVYGDTALTFFQKGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UW3</accession>
    <name>Q39UW3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl:acetate coenzyme A transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ato-2</name>
        <name evidence="3" type="ordered locus">Gmet_1730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513373.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1730"/>
    <dbReference type="EnsemblBacteria" id="ABB31961">
        <property type="protein sequence ID" value="ABB31961"/>
        <property type="gene ID" value="Gmet_1730"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1730"/>
    <dbReference type="eggNOG" id="COG0427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019748_3_0_7"/>
    <dbReference type="OMA" id="GLHDIWI"/>
    <dbReference type="OrthoDB" id="319106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="327"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="520" mass="57659" checksum="44EDB91B01C4E6DD" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V25</accession>
    <name>Q39V25_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511395.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1668"/>
    <dbReference type="EnsemblBacteria" id="ABB31899">
        <property type="protein sequence ID" value="ABB31899"/>
        <property type="gene ID" value="Gmet_1668"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1668"/>
    <dbReference type="eggNOG" id="ENOG5032YBM">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093136_1_1_7"/>
    <dbReference type="OMA" id="NAPMVLC"/>
    <dbReference type="OrthoDB" id="1859899at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025293">
        <property type="entry name" value="YfiR/HmsC-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13689">
        <property type="entry name" value="DUF4154"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="182" mass="20290" checksum="A35561D8BCB30894" modified="2005-11-22" version="1">MIKRAVTILIILAWCILSLPTVQAEERLPSEYQVKLAFLLNFARFVEWPKDAFADATSPIVLGILGDDPFGTSLASIRGKTIHGRKVLINKFKDVDDIRDCHILFVSSSEKNHLSRIIPFLRQAKILSVGDMRKFAQKGGVINFVVENDKVGFEINVDAGKRAGLQISSKLLSLARIVRDSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V45</accession>
    <name>Q39V45_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511416.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31879">
        <property type="protein sequence ID" value="ABB31879"/>
        <property type="gene ID" value="Gmet_1648"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1648"/>
    <dbReference type="HOGENOM" id="CLU_145321_0_0_7"/>
    <dbReference type="OMA" id="GKQWTES"/>
    <dbReference type="OrthoDB" id="2049214at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223335" evidence="1">
        <location>
            <begin position="21"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="16039" checksum="F08D0A50B48ABAC8" modified="2005-11-22" version="1">MQLPKLVCVCCVLALVGATAGTYNDARAAEEKPVTDTSASLKEMPLLDGEVWQAMTASERIAFIWGIGHVVTMEREAAEQRPELKKAGLAAKMAEGLSGIPMNEITGMITEYYKENPGSLKEPVMKVLWDRIVNPRIKAGFVEGTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VG1</accession>
    <name>Q39VG1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Benzoylsuccinyl-CoA thiolase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">bbsB</name>
        <name evidence="4" type="ordered locus">Gmet_1529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7 8" key="3">
        <citation type="journal article" date="2022" name="FEBS J." volume="0" first="0" last="0">
            <title>Finis tolueni: a new type of thiolase with an integrated Zn-finger subunit catalyzes the final step of anaerobic toluene metabolism.</title>
            <authorList>
                <person name="Weidenweber S."/>
                <person name="Schuhle K."/>
                <person name="Lippert M.L."/>
                <person name="Mock J."/>
                <person name="Seubert A."/>
                <person name="Demmer U."/>
                <person name="Ermler U."/>
                <person name="Heider J."/>
            </authorList>
            <dbReference type="PubMed" id="35313080"/>
            <dbReference type="DOI" id="10.1111/febs.16443"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511538.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="7PXP">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="C/D/G/H=1-390"/>
    </dbReference>
    <dbReference type="PDB" id="7PYT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="B/D=1-390"/>
    </dbReference>
    <dbReference type="PDB" id="7YXM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="B/D=1-390"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1529"/>
    <dbReference type="EnsemblBacteria" id="ABB31763">
        <property type="protein sequence ID" value="ABB31763"/>
        <property type="gene ID" value="Gmet_1529"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1529"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035425_4_0_7"/>
    <dbReference type="OMA" id="PSLYAMM"/>
    <dbReference type="OrthoDB" id="311458at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6 7 8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="2">
        <location>
            <begin position="7"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="3">
        <location>
            <begin position="261"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="7PXP"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="7PYT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="7YXM"/>
        </source>
    </evidence>
    <sequence length="390" mass="41433" checksum="05F4C5CB5B3A5541" modified="2005-11-22" version="1">MKLQREVYIAGVGETKFGKHTVDFDVLGREAALQAMNGSNIDRPDMIQSAYVGNGMNDMTTGQAVFRGLGMCGPNLPIINVQSACSAGAMAVFCAIKDVATGVTDLSIGVGTENHTMHRQSGAAFSAARSDIETMHGAVMTGKYAMRATRYMHETGATIEDLAMITVKNRKHATHNPYAWFKGAITVEEVVNSRMVAYPMTLQQCCGIADGAAAVVVGSKEMMKKLGIAKPVKVAGVVVESGPYHNRPRDITGDDITETTSEKLYEESGIGPKEVNILELHDAFTIAELLYYECMGLCKKGDGLKFLRDGQSTYGGQCVVSPRGGLLSYGHPIGASGAAQIAQNVKQLRGECGGYQVGPTPKVAMSHVTGGGLSGTEHAACTMHMLVKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VG5</accession>
    <name>Q39VG5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">etfB-5</name>
        <name evidence="4" type="ordered locus">Gmet_1525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6" key="3">
        <citation type="journal article" date="2019" name="J. Bacteriol." volume="201" first="0" last="0">
            <title>Structural and Functional Characterization of an Electron Transfer Flavoprotein Involved in Toluene Degradation in Strictly Anaerobic Bacteria.</title>
            <authorList>
                <person name="Vogt M.S."/>
                <person name="Schuhle K."/>
                <person name="Kolzer S."/>
                <person name="Peschke P."/>
                <person name="Chowdhury N.P."/>
                <person name="Kleinsorge D."/>
                <person name="Buckel W."/>
                <person name="Essen L.O."/>
                <person name="Heider J."/>
            </authorList>
            <dbReference type="PubMed" id="31405915"/>
            <dbReference type="DOI" id="10.1128/JB.00326-19"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511542.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="5OW0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.70 A"/>
        <property type="chains" value="B=1-251"/>
    </dbReference>
    <dbReference type="PDBsum" id="5OW0"/>
    <dbReference type="SMR" id="Q39VG5"/>
    <dbReference type="STRING" id="269799.Gmet_1525"/>
    <dbReference type="EnsemblBacteria" id="ABB31759">
        <property type="protein sequence ID" value="ABB31759"/>
        <property type="gene ID" value="Gmet_1525"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1525"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_1_0_7"/>
    <dbReference type="OMA" id="EELYLVI"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="5OW0"/>
        </source>
    </evidence>
    <sequence length="251" mass="27255" checksum="25AC5AD794CFB5EF" modified="2005-11-22" version="1">MQIVVLAKVVPDYEVPSADFELVGNRAHPRYTRMIGLYDENAVELGVQLKEKLGADLTVVSYGRNDDVQFLRKALAMGADKVVLVEGDSDDPYVIAANLKDAIDRQGTVDLILAGRQSSDMDRGVVPGVLAGMLDLPFVPQACSVESVDGGWKISQITETGKRLLKLSGKGVLSITSVPENVPRIPAVKAIFAAKKKPVEKLPEIGTGKMAVSELSVSIPKVESNCELIPAEDMDDAVRVLLRRLKEERYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VL7</accession>
    <name>Q39VL7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1473</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511595.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31707">
        <property type="protein sequence ID" value="ABB31707"/>
        <property type="gene ID" value="Gmet_1473"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1473"/>
    <dbReference type="eggNOG" id="ENOG50346UY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1530423_0_0_7"/>
    <dbReference type="OMA" id="DLNRIEM"/>
    <dbReference type="OrthoDB" id="1930051at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="SSF47794"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="174" mass="19317" checksum="494EB33DC89B1D02" modified="2005-11-22" version="1">MKKSLQDLQKIRGIGEVLAKRLVEAGHDTYEKLQALGEDGLRAVKGINPRAIGSILSQAAELVESKGKERARRVEELRSAALTLRGQVEEIARSVRDRFADEVQGQGGKKLEKQFTKIMTSFDRVEGKLEKRTKRAAKGLAKAEKRLAGLVDGTMKDVEKGVRRARKSLKRILA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-10-14" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VS0</accession>
    <name>PIMT_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-L-isoaspartate O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">L-isoaspartyl protein carboxyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein L-isoaspartyl methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protein-beta-aspartate methyltransferase</fullName>
            <shortName evidence="1">PIMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pcm</name>
        <name type="ordered locus">Gmet_1420</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-isoaspartate + S-adenosyl-L-methionine = [protein]-L-isoaspartate alpha-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:12705"/>
            <dbReference type="Rhea" id="RHEA-COMP:12143"/>
            <dbReference type="Rhea" id="RHEA-COMP:12144"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90596"/>
            <dbReference type="ChEBI" id="CHEBI:90598"/>
            <dbReference type="EC" id="2.1.1.77"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.77" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511647.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VS0"/>
    <dbReference type="SMR" id="Q39VS0"/>
    <dbReference type="STRING" id="269799.Gmet_1420"/>
    <dbReference type="EnsemblBacteria" id="ABB31654">
        <property type="protein sequence ID" value="ABB31654"/>
        <property type="gene ID" value="Gmet_1420"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1420"/>
    <dbReference type="eggNOG" id="COG2518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055432_2_0_7"/>
    <dbReference type="OMA" id="DGNKGWE"/>
    <dbReference type="OrthoDB" id="1948290at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004719">
        <property type="term" value="F:protein-L-isoaspartate (D-aspartate) O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030091">
        <property type="term" value="P:protein repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00090">
        <property type="entry name" value="PIMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000682">
        <property type="entry name" value="PCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11579">
        <property type="entry name" value="PTHR11579"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00080">
        <property type="entry name" value="pimt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01279">
        <property type="entry name" value="PCMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000351861" description="Protein-L-isoaspartate O-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00090"/>
        </source>
    </evidence>
    <sequence length="216" mass="23890" checksum="24E8847AC0C10375" modified="2005-11-22" version="1">MNFDIARKRMVETQIISRGVKDRRLIEAMLKVPRHVFVEEAMAAQAYSDTPLPIGEKQTISQPYMVALMTELLELSGREKVLEIGTGSGYQAAILATLADRVYTVERIRPLALKARRALDRLGLLNVNIKISDGTIGWEEEAPFDAIIVTAGAPDVPDKLAEQLAVGGRLVIPVGNQFDQVLVRITKQEDGSLIRENVTGCRFVKLVGKYGWGTEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VY3</accession>
    <name>SYDND_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartate--tRNA(Asp/Asn) ligase</fullName>
            <ecNumber evidence="1">6.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Aspartyl-tRNA synthetase</fullName>
            <shortName evidence="1">AspRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-discriminating aspartyl-tRNA synthetase</fullName>
            <shortName evidence="1">ND-AspRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aspS</name>
        <name type="ordered locus">Gmet_1357</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + tRNA(Asx) = AMP + diphosphate + L-aspartyl-tRNA(Asx)</text>
            <dbReference type="Rhea" id="RHEA:18349"/>
            <dbReference type="Rhea" id="RHEA-COMP:9710"/>
            <dbReference type="Rhea" id="RHEA-COMP:9711"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.23"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513151.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VY3"/>
    <dbReference type="SMR" id="Q39VY3"/>
    <dbReference type="STRING" id="269799.Gmet_1357"/>
    <dbReference type="EnsemblBacteria" id="ABB31591">
        <property type="protein sequence ID" value="ABB31591"/>
        <property type="gene ID" value="Gmet_1357"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1357"/>
    <dbReference type="eggNOG" id="COG0173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014330_3_2_7"/>
    <dbReference type="OMA" id="YQLDVEM"/>
    <dbReference type="OrthoDB" id="226836at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050560">
        <property type="term" value="F:aspartate-tRNA(Asn) ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00044">
        <property type="entry name" value="Asp_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004524">
        <property type="entry name" value="Asp-tRNA-ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029351">
        <property type="entry name" value="GAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="PTHR22594:SF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02938">
        <property type="entry name" value="GAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55261">
        <property type="entry name" value="SSF55261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00459">
        <property type="entry name" value="aspS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000235529" description="Aspartate--tRNA(Asp/Asn) ligase">
        <location>
            <begin position="1"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Aspartate" evidence="1">
        <location>
            <begin position="206"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="541"/>
            <end position="544"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="site" description="Important for tRNA non-discrimination" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00044"/>
        </source>
    </evidence>
    <sequence length="594" mass="66613" checksum="0ABEFD700FBEA08C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VZ5</accession>
    <name>Q39VZ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Periplasmic polysaccharide biosynthesis/export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1345</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1345"/>
    <dbReference type="EnsemblBacteria" id="ABB31579">
        <property type="protein sequence ID" value="ABB31579"/>
        <property type="gene ID" value="Gmet_1345"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1345"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011447_2_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="117"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="209"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="306"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="2">
        <location>
            <begin position="447"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="381"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="568" mass="62319" checksum="0E47163202EC6AE1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W66</accession>
    <name>Q39W66_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, periplasmic substrate-binding protein, MCE domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1272</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365795.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1272"/>
    <dbReference type="DNASU" id="3739771"/>
    <dbReference type="EnsemblBacteria" id="ABB31508">
        <property type="protein sequence ID" value="ABB31508"/>
        <property type="gene ID" value="Gmet_1272"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1272"/>
    <dbReference type="eggNOG" id="COG1463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054524_0_1_7"/>
    <dbReference type="OMA" id="KLNPKRY"/>
    <dbReference type="OrthoDB" id="807474at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003399">
        <property type="entry name" value="Mce/MlaD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02470">
        <property type="entry name" value="MlaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MlaD" evidence="1">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="347" mass="37029" checksum="EF032B6410F3835B" modified="2005-11-22" version="1">MSIEKKVGFFFIAGLVLLGVMLELGEKWNPFQKAIPYKTYLSSTTGLKLGDPVRLAGVEVGKITKIAIADSRVEVAFEVKPGTAIKADSVATIRLTNLLGGQFLGLSFGSPDAPVLPPGSAVKSRETANIDVIVDNVGDLAKDAKVLIKDLTVNQKEVFQKVSSMLDENRGNLRGAIENMNSITTKMDRGQGSLALLLNDKSLYRNTNELAASMKNVTAKIEKGEGSLGKFVNDDAFYRDAKGAVANLNDGAKDIKEIAAKINRGEGSVGKLVNDESLYNELRDASKNVGEVAKKINNGQGTLGKLVNDDTLYRDTTAAMKKLDKATEGLSDTGPISVIGSMVGTLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WM2</accession>
    <name>Q39WM2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bidirectional NAD-reducing hydrogenase, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hoxS</name>
        <name evidence="5" type="ordered locus">Gmet_1112</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513768.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1112"/>
    <dbReference type="EnsemblBacteria" id="ABB31352">
        <property type="protein sequence ID" value="ABB31352"/>
        <property type="gene ID" value="Gmet_1112"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1112"/>
    <dbReference type="eggNOG" id="COG1941">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093095_0_0_7"/>
    <dbReference type="OMA" id="CNAENVH"/>
    <dbReference type="OrthoDB" id="1280734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037024">
        <property type="entry name" value="NiFe_Hase_small_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0574">Periplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_q6" evidence="4">
        <location>
            <begin position="17"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="180" mass="19498" checksum="86B984E0A11C0661" modified="2005-11-22" version="1">MGRRGRIRFATVWLGGCSGCHMSFLDLDERLVELAGLADMVYGPFMDAKEFPRKVDVTLVEGAVTNRANLAMALMLRERSRIVVSLGDCAVTGNVTSLRNQLPVADVLATFLSCGEGSVPAMDYNAVPELLPRALPLHQVIAVDGFLPGCPPDPERIWTAIGCLLRGEPVHLESDMLTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WQ0</accession>
    <name>Q39WQ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1084</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513740.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1084"/>
    <dbReference type="EnsemblBacteria" id="ABB31324">
        <property type="protein sequence ID" value="ABB31324"/>
        <property type="gene ID" value="Gmet_1084"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1084"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_1_7"/>
    <dbReference type="OMA" id="GATACIH"/>
    <dbReference type="OrthoDB" id="750230at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="297" mass="31938" checksum="460249EF0670D6F1" modified="2005-11-22" version="1">MNLKQLEVFLAVAESGSFSRGAEATFITQSTVSQHIAALENELGVKLLDRTGRGALLTEGGKLLLEHARRVVAGAREIEPAMRRFRGVEEAELRVGGSNIPGDHMIPEILPLFLARHPGVRLTLLQGDSREILDKVAREEVEIGIIGSRFDDEGFAFTPLGRDEIRLIAGSAHPLAGRGPVGIDVLARQEFIMREPGSGTARTIAHALAGAGVAPATLAVRASLGSNEAVKHAVASGLGVSFLSEISVRKELGRGELVEIPVDGLKISRTFYLVQRDGRELSPAARAFADLMREQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WQ3</accession>
    <name>Q39WQ3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513737.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1081"/>
    <dbReference type="EnsemblBacteria" id="ABB31321">
        <property type="protein sequence ID" value="ABB31321"/>
        <property type="gene ID" value="Gmet_1081"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1081"/>
    <dbReference type="HOGENOM" id="CLU_148572_0_0_7"/>
    <dbReference type="OMA" id="FMSESAT"/>
    <dbReference type="OrthoDB" id="2092108at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="111" mass="12023" checksum="74F33F865C2649E5" modified="2005-11-22" version="1">MPENAPGTLTIRLTGDWSMTGVTQQLLPLTEHLAALSGVHPQQVQPVIDMAEVALFDACGCQLLTILLRHLRLLGFSPVLANIPAELRGSIELLGFGHEFETMLDVTRGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WV4</accession>
    <name>Q39WV4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase, beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513203.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1030"/>
    <dbReference type="EnsemblBacteria" id="ABB31270">
        <property type="protein sequence ID" value="ABB31270"/>
        <property type="gene ID" value="Gmet_1030"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1030"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_936152_0_0_7"/>
    <dbReference type="OMA" id="IERPVIW"/>
    <dbReference type="OrthoDB" id="775108at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223472" evidence="1">
        <location>
            <begin position="24"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Lactamase_B" evidence="2">
        <location>
            <begin position="47"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="282" mass="31460" checksum="E8EAE5D0769A005F" modified="2005-11-22" version="1">MKKLLLSLTLTVLLGLLGRPAIAANYEIKLVDEGVFAAIALPEGKAASNALIIITPHQVILAGAHFVPEGIKELIADIAEITPLPLRSVILTHHHKGFNYVDFDFPANVEIITSWQTWQALKAETRPLRNPVTFFEKGLTLLRSNTTIVLSSADFGHTEGDVFLFLPNEGILFASDLFYNDVVGYMGEGHMRDWVITLETLEAVGAQYVVPGLGQVTDRSGLRRFRLFFKDFLTEVLRHMEAGKTLAETKKLFRLPAHEGMPGYKAFLDVNLDRAYQDLRDQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X47</accession>
    <name>RNH_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease H</fullName>
            <shortName evidence="1">RNase H</shortName>
            <ecNumber evidence="1">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rnhA</name>
        <name type="ordered locus">Gmet_0935</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase H family.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514418.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X47"/>
    <dbReference type="SMR" id="Q39X47"/>
    <dbReference type="STRING" id="269799.Gmet_0935"/>
    <dbReference type="EnsemblBacteria" id="ABB31177">
        <property type="protein sequence ID" value="ABB31177"/>
        <property type="gene ID" value="Gmet_0935"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0935"/>
    <dbReference type="eggNOG" id="COG0328">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030894_6_0_7"/>
    <dbReference type="OMA" id="MQEIEIF"/>
    <dbReference type="OrthoDB" id="1953872at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09278">
        <property type="entry name" value="RNase_HI_prokaryote_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00042">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022892">
        <property type="entry name" value="RNaseHI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000332605" description="Ribonuclease H">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00408"/>
        </source>
    </evidence>
    <sequence length="152" mass="17168" checksum="B621E3B64A16BCB4" modified="2005-11-22" version="1">MSTRVELFCDGACSGNPGVGGWGGILRCGATEKELSGAEWETTNNRMEMTAAIRGLEALTRPCEVVVTTDSQYLVKGMTEWLSGWIRRGWVNSKKEPVLNRDLWERLLELSKTHRIQWTWIRGHNGHAENERCDALARGAIDELRKKGQGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X76</accession>
    <name>Q39X76_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0906</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513936.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0906"/>
    <dbReference type="EnsemblBacteria" id="ABB31148">
        <property type="protein sequence ID" value="ABB31148"/>
        <property type="gene ID" value="Gmet_0906"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0906"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040020_1_0_7"/>
    <dbReference type="OMA" id="FGFHRMM"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="331"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="8"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="386" mass="41050" checksum="44BAD408EBD959BF" modified="2005-11-22" version="1">MFRGISGNVLIFGLVSFLTDVSSEMIYPLLPLFLTTVLGAGPAFLGLIEGVAESTAAFLKLVSGILSDRVRSRKGLVLGGYALSSLARPLVAAATAPSAILAIRFADRVGKGIRTSPRDALIADSTDPAFRGKAFGFHRAMDHAGALVGPLIATLLLAWFVKDLRTVFWLAAIPGFLAVVLIIWKVRETARVRTGDGTFLRIVPHGDLRRFLLILFLFTLGNSSDAFLLLRAGELGVTPARIPLLWAFFHLVKMAGSTPFGALSDRIGRRGVIVVGWGVYALSYGGFALAETEVACWLLFAFYGLFYAMTEGAEKALLADLAPSRERGSAFGWYNFAVGAGALPASLLFGAVWEKAGRVAAFGFGAALAALAAVLLLSLVRAPARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X84</accession>
    <name>Q39X84_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0898"/>
    <dbReference type="EnsemblBacteria" id="ABB31140">
        <property type="protein sequence ID" value="ABB31140"/>
        <property type="gene ID" value="Gmet_0898"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0898"/>
    <dbReference type="eggNOG" id="ENOG5033JKA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_200336_0_0_7"/>
    <dbReference type="OMA" id="CTFCQWC"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="65" mass="7182" checksum="1C949DCA2FCB6AB8" modified="2005-11-22" version="1">MPPTEPPKKHPCPDCRCCQWCGDDRCSLCLRGGKKGKKLSLAEQIELFEKVNSKASATEGTEDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X99</accession>
    <name>Q39X99_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-glucuronate 4-dehydrogenase, decarboxylating</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">arnA</name>
        <name evidence="2" type="ordered locus">Gmet_0883</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513030.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0883"/>
    <dbReference type="EnsemblBacteria" id="ABB31125">
        <property type="protein sequence ID" value="ABB31125"/>
        <property type="gene ID" value="Gmet_0883"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0883"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_7_0_7"/>
    <dbReference type="OMA" id="WIYSCAK"/>
    <dbReference type="OrthoDB" id="1566711at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05257">
        <property type="entry name" value="Arna_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045869">
        <property type="entry name" value="Arna-like_SDR_e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="346" mass="39640" checksum="457DB445A9DF0E3C" modified="2005-11-22" version="1">MKILILGVNGFIGNALTKRILDTTDWEVYGLDMSDNKLEHSIGHPRFHFLEGDITINKEWIEYNIKKCDVVLPLVAIATPVTYVKDPLRVFELDFEENLKIIRQCVKYKKRVIFPSTSEVYGMSPDREFDEENSPLMLGPINKQRWIYSCAKQMLDRVIYAYGEQEGLRYTLFRPFNWIGPKLDSISTAKEGSSRVLTQFLYNILAGEPIQLVDGGNQRRSFTFVEDGIDCLMKIIENKDGSADGGIFNIGNPGNDLSVKELAEKLITLVKEYPAYRDRAEACRIIEVSSGQFYGKGYQDMLTRVPSVKNAKARLGWEPKTVIDDALRKTLDFYLIEEKEKIEHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XE7</accession>
    <name>Q39XE7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512979.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0835"/>
    <dbReference type="EnsemblBacteria" id="ABB31077">
        <property type="protein sequence ID" value="ABB31077"/>
        <property type="gene ID" value="Gmet_0835"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0835"/>
    <dbReference type="eggNOG" id="ENOG50343ZC">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2154754_0_0_7"/>
    <dbReference type="OMA" id="ATHWMGV"/>
    <dbReference type="OrthoDB" id="1884308at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="111" mass="12753" checksum="DFBC48B227F9CCE9" modified="2005-11-22" version="1">MPEFSDVPRDMDVLDSILSKETKNGFLVDVRLVKRPRQYEAALFLNGKYKPGPPVPRPLDNPTTDASHWMGVRPSVGFSPEEADAITDEVMSQNRLRRLTFTDRWGREYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XP7</accession>
    <name>Q39XP7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type IV pilus minor pilin PilW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pilW-1</name>
        <name evidence="2" type="ordered locus">Gmet_0735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514452.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0735"/>
    <dbReference type="EnsemblBacteria" id="ABB30977">
        <property type="protein sequence ID" value="ABB30977"/>
        <property type="gene ID" value="Gmet_0735"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0735"/>
    <dbReference type="HOGENOM" id="CLU_803535_0_0_7"/>
    <dbReference type="OMA" id="YYVDAGM"/>
    <dbReference type="OrthoDB" id="1590027at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="345" mass="37357" checksum="10424953C2996409" modified="2005-11-22" version="1">MTCEALTAQPRSMGGYTLVEVLVVIVILAVISAGLSTVFITGQKEYGVREATIRMQQQARQAMNEMERELKNTGYGLMDMGDLTVKVYKSSGAIPSWQVVEASDGGTEPDSIKVLYSGAESDVGYDYIVSVDHPTSSALMLVSAVGSVPPSRTLNDDFIKGDLFLVYDPSDPGKPATRFQATNVTAPDKIHHNPGGYNPSGGTLDVAYGVGSKVLNLRLMQAKSVSYSVDARQNLIKTVEDLSLIDPPANQRTKIVASGVEDLQIRYQFKDGTWKNAGDPGFVAKDLRAIQVSIIVRTEKPDPRYPGQSLQLTGSYGNGGVKNSAGYRRMAMSTIIYVRNLGFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XW3</accession>
    <name>Q39XW3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitrogenase iron-molybdenum cofactor biosynthesis protein NifE</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Nitrogenase iron-molybdenum cofactor biosynthesis protein NifN</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nifEN</name>
        <name evidence="9" type="ordered locus">Gmet_0669</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein may play a role in the biosynthesis of the prosthetic group of nitrogenase (FeMo cofactor).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; Fe-Mo cofactor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the NifD/NifK/NifE/NifN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514277.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0669"/>
    <dbReference type="EnsemblBacteria" id="ABB30911">
        <property type="protein sequence ID" value="ABB30911"/>
        <property type="gene ID" value="Gmet_0669"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0669"/>
    <dbReference type="eggNOG" id="COG2710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013317_1_0_7"/>
    <dbReference type="OMA" id="ASTPDYC"/>
    <dbReference type="OrthoDB" id="363662at2"/>
    <dbReference type="UniPathway" id="UPA00782"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016163">
        <property type="term" value="F:nitrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065003">
        <property type="term" value="P:protein-containing complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01966">
        <property type="entry name" value="Nitrogenase_NifN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000510">
        <property type="entry name" value="Nase/OxRdtase_comp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000318">
        <property type="entry name" value="Nase_comp1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005975">
        <property type="entry name" value="Nase_Mo-Fe_CF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005973">
        <property type="entry name" value="NifE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00148">
        <property type="entry name" value="Oxidored_nitro"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01283">
        <property type="entry name" value="nifE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01285">
        <property type="entry name" value="nifN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00699">
        <property type="entry name" value="NITROGENASE_1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00090">
        <property type="entry name" value="NITROGENASE_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Oxidored_nitro" evidence="8">
        <location>
            <begin position="36"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Oxidored_nitro" evidence="8">
        <location>
            <begin position="501"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="919" mass="100018" checksum="88C8EC9501547D9C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XX6</accession>
    <name>Q39XX6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">ybhS-1</name>
        <name evidence="7" type="ordered locus">Gmet_0656</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514264.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0656"/>
    <dbReference type="EnsemblBacteria" id="ABB30898">
        <property type="protein sequence ID" value="ABB30898"/>
        <property type="gene ID" value="Gmet_0656"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0656"/>
    <dbReference type="eggNOG" id="COG0842">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039483_8_3_7"/>
    <dbReference type="OMA" id="DHLLVMP"/>
    <dbReference type="OrthoDB" id="1552415at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000412">
        <property type="entry name" value="ABC_2_transport"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51012">
        <property type="entry name" value="ABC_TM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="377" mass="41623" checksum="0466041076B8A343" modified="2005-11-22" version="1">MKLQRVAAVARKEFIHVFRDPRSLGMGIAIPMLLLFLFGYALTLDVDRVPLMVWDQSATPESRDFISHFAGSRYFTLAGRVGTYREIEIAIDRRDVLMALVIPTDFARKVRTGMPAPVQLILDGSDSNTATIALGYAEAVTSVWAREVVLEQTRRFGPVPAAGSVDVRPRVWFNTDMVSRNYIFPGLIAVIMMVIAALLTSLTVAREWETGTMEQLITTPLRGAELIVGKLIPYFAIGILDLVLSVLVGEFVFDIPLRGSLWLLFAMSLIFLTCALAFGLLISIVTKNQRLASQTAMVTTMLPAFLLSGFIFPIENMPPPIQAVTHIITARYFVTILRDIYLKGVGLGVLAPEAAFLAVFGVVVLALAVKKFRKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y27</accession>
    <name>Q39Y27_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Aspartate-semialdehyde dehydrogenase</fullName>
            <shortName evidence="12">ASA dehydrogenase</shortName>
            <shortName evidence="12">ASADH</shortName>
            <ecNumber evidence="7 12">1.2.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aspartate-beta-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">asd</name>
        <name evidence="14" type="synonym">asd-1</name>
        <name evidence="14" type="ordered locus">Gmet_0604</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:24284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.2.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 12">Belongs to the aspartate-semialdehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.11" evidence="7 12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514734.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0604"/>
    <dbReference type="EnsemblBacteria" id="ABB30847">
        <property type="protein sequence ID" value="ABB30847"/>
        <property type="gene ID" value="Gmet_0604"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0604"/>
    <dbReference type="eggNOG" id="COG0136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049966_0_1_7"/>
    <dbReference type="OMA" id="CEEEMKM"/>
    <dbReference type="OrthoDB" id="1799040at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00016"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00463"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00464"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004073">
        <property type="term" value="F:aspartate-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019877">
        <property type="term" value="P:diaminopimelate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02121">
        <property type="entry name" value="ASADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012080">
        <property type="entry name" value="Asp_semialdehyde_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005986">
        <property type="entry name" value="Asp_semialdehyde_DH_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01296">
        <property type="entry name" value="asd_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 12" id="KW-0220">Diaminopimelate biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11 12" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Semialdhyde_dh" evidence="13">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="12">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="13"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="41"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="162"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="339" mass="36630" checksum="FECF01757F6C5628" modified="2005-11-22" version="1">MAKLWNVAVVGATGAVGGQMIECLEERNFPVGKIRYLASARSAGEVLEFKGKPVMVEELTRDSFEGIDIALFSAGGDRSRDFCPAAAAAGAVCIDNSSAWRMDPDVPLVVPEVNPHAIADYRKKGIIANPNCSTIQMVVALKPLHDHAVIRRIVVSTYQAVSGTGKKAIEELQKQVVTLFQGKSPEVATYPHQIAFNCLPQIDSFGDNGYTKEEMKMVHETRKILEANIGVTATAVRVPVFYGHSESVNIETENKLTVATARELLAKAPGVELVDDPATSSYPMAIDAAGQDLTLVGRIREDESIANGLNLWVVADNIRKGAATNAVQIAEILIEKYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y68</accession>
    <name>Q39Y68_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein DUF318</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0563</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512260.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0563"/>
    <dbReference type="EnsemblBacteria" id="ABB30806">
        <property type="protein sequence ID" value="ABB30806"/>
        <property type="gene ID" value="Gmet_0563"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0563"/>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_431347_0_0_7"/>
    <dbReference type="OMA" id="RLRCNCR"/>
    <dbReference type="OrthoDB" id="279684at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="305"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="633" mass="67438" checksum="E30ECC9C0FE1D45A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y75</accession>
    <name>Q39Y75_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NHL repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512253.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0556"/>
    <dbReference type="EnsemblBacteria" id="ABB30799">
        <property type="protein sequence ID" value="ABB30799"/>
        <property type="gene ID" value="Gmet_0556"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0556"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_322049_0_0_7"/>
    <dbReference type="OMA" id="VITEGAW"/>
    <dbReference type="OrthoDB" id="210490at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036439">
        <property type="entry name" value="Dockerin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63446">
        <property type="entry name" value="SSF63446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223513" evidence="3">
        <location>
            <begin position="30"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="114"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="161"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="899" mass="92223" checksum="C07C1BE7C724B6F2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="127" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YE6</accession>
    <name>Q39YE6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Cobyric acid synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cbiH</name>
        <name evidence="14" type="synonym">cbiP</name>
        <name evidence="10" type="synonym">cobQ</name>
        <name evidence="14" type="ordered locus">Gmet_0485</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513854.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0485"/>
    <dbReference type="EnsemblBacteria" id="ABB30728">
        <property type="protein sequence ID" value="ABB30728"/>
        <property type="gene ID" value="Gmet_0485"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0485"/>
    <dbReference type="eggNOG" id="COG1010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019250_1_0_7"/>
    <dbReference type="OMA" id="DVRMNPL"/>
    <dbReference type="OrthoDB" id="744477at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015420">
        <property type="term" value="F:ABC-type vitamin B12 transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01750">
        <property type="entry name" value="GATase1_CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11646">
        <property type="entry name" value="Precorrin_3B_C17_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00028">
        <property type="entry name" value="CobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006363">
        <property type="entry name" value="Cbl_synth_CobJ/CibH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033949">
        <property type="entry name" value="CobQ_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004459">
        <property type="entry name" value="CobQ_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21343:SF1">
        <property type="entry name" value="PTHR21343:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01466">
        <property type="entry name" value="cobJ_cbiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00313">
        <property type="entry name" value="cobQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="12">
        <location>
            <begin position="3"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="13">
        <location>
            <begin position="550"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="242"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="797" mass="84954" checksum="2028BF441F155C65" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YK9</accession>
    <name>Q39YK9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0422</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512394.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0422"/>
    <dbReference type="EnsemblBacteria" id="ABB30665">
        <property type="protein sequence ID" value="ABB30665"/>
        <property type="gene ID" value="Gmet_0422"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0422"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_10_7"/>
    <dbReference type="OMA" id="HMFARAI"/>
    <dbReference type="OrthoDB" id="572620at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="259" mass="27946" checksum="9ECC0DE749EB9784" modified="2005-11-22" version="1">MSLKGKTAIVTGAGRGLGRASAMALAREGADLVILSRTPKELEETATLVMEAGGTVVIQEGDVANPADVRRVVGTAVETFESVDILMNNAAVIGPVRALHQLAPEEWAYAMAVNLTGPWLFAREVIPHMIRQKRGKIINVISGLGEIVISPFGAYAIAKAGLIHMTRYLAEELKVHNIQVNGLDPAVMDTRMQEDIRGLGPAVLGPDVFADFTAMKDRKELLPPERVARLAVFLASAESDRVTGENGTVSHFRTFGYRY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-04-29" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YL7</accession>
    <name>MURB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylenolpyruvoylglucosamine reductase</fullName>
            <ecNumber evidence="1">1.3.1.98</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murB</name>
        <name type="ordered locus">Gmet_0414</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + UDP-N-acetyl-alpha-D-muramate = H(+) + NADPH + UDP-N-acetyl-3-O-(1-carboxyvinyl)-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:12248"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:68483"/>
            <dbReference type="ChEBI" id="CHEBI:70757"/>
            <dbReference type="EC" id="1.3.1.98"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurB family.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.98" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512386.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YL7"/>
    <dbReference type="SMR" id="Q39YL7"/>
    <dbReference type="STRING" id="269799.Gmet_0414"/>
    <dbReference type="EnsemblBacteria" id="ABB30657">
        <property type="protein sequence ID" value="ABB30657"/>
        <property type="gene ID" value="Gmet_0414"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0414"/>
    <dbReference type="eggNOG" id="COG0812">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035304_1_1_7"/>
    <dbReference type="OMA" id="KMNAGMK"/>
    <dbReference type="OrthoDB" id="841869at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008762">
        <property type="term" value="F:UDP-N-acetylmuramate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.78.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00037">
        <property type="entry name" value="MurB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003170">
        <property type="entry name" value="MurB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011601">
        <property type="entry name" value="MurB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036635">
        <property type="entry name" value="MurB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21071">
        <property type="entry name" value="PTHR21071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02873">
        <property type="entry name" value="MurB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56194">
        <property type="entry name" value="SSF56194"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00179">
        <property type="entry name" value="murB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000332461" description="UDP-N-acetylenolpyruvoylglucosamine reductase">
        <location>
            <begin position="1"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="30"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="174"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00037"/>
        </source>
    </evidence>
    <sequence length="300" mass="31999" checksum="0A44F692624AE89F" modified="2005-11-22" version="1">MNDELYARLRAELRGEILRDEPMARHTSLKVGGAADFFVTPADRDDLTALLALLAETGTPYLVVGGGYNLLVRDGGIRGVVISLARLDEMTLLAGERVMAGAGVTNRQFVQLLRDRGLGGLEFLCGIPGTVGGALAMNAGAHGGAVVDRVEELLTIRDGEMLQTGRDGLDYGYRFLRLAPGEIIVGATFRLDPADPDQIGARIAGYLEHRAASQKVGFPNAGSFFKNPEGTAAWRLIDETGLRGERVGGAQVSEAHANFLINRGGATAADFLALATRINEAVKQRTGITLEEEVRIVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YQ0</accession>
    <name>Q39YQ0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Release factor glutamine methyltransferase</fullName>
            <shortName evidence="6">RF MTase</shortName>
            <ecNumber evidence="6">2.1.1.297</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">N5-glutamine methyltransferase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-(glutamine-N5) MTase PrmC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Protein-glutamine N-methyltransferase PrmC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">hemK</name>
        <name evidence="6" type="synonym">prmC</name>
        <name evidence="9" type="ordered locus">Gmet_0381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = H(+) + N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512353.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0381"/>
    <dbReference type="EnsemblBacteria" id="ABB30624">
        <property type="protein sequence ID" value="ABB30624"/>
        <property type="gene ID" value="Gmet_0381"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0381"/>
    <dbReference type="eggNOG" id="COG2890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018398_3_1_7"/>
    <dbReference type="OMA" id="FDARYWE"/>
    <dbReference type="OrthoDB" id="1816476at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:protein-(glutamine-N5) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036009">
        <property type="term" value="F:protein-glutamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018364">
        <property type="term" value="P:peptidyl-glutamine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02126">
        <property type="entry name" value="RF_methyltr_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040758">
        <property type="entry name" value="PrmC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019874">
        <property type="entry name" value="Release_fac_Glu-N5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17827">
        <property type="entry name" value="PrmC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03534">
        <property type="entry name" value="RF_mod_PrmC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PrmC_N" evidence="8">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="MTS" evidence="7">
        <location>
            <begin position="104"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="125"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="6">
        <location>
            <begin position="190"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="284" mass="30899" checksum="29A51A9F702A81D8" modified="2005-11-22" version="1">MTEKPETWTIRRVLDWTKGYLAEKGVENARLETEWLLSAALGLDRVGLYVNFDKPLNAEELSAVRGLVARRAKREPLQYVLGTQEFCGLDFAVTPAVLIPRHDTEVLVEEALRRAPHAATVLDIGVGSGCIAVALAKNLPDAQVWGVEQSAGAITLARQNVERHGVRVILCAGSLFEPFADQRFDLIVSNPPYIPTADLDTLQPEVREYEPRAALDGGADGLDFYRIIVPAALEHLNAGGWLMVELGIGQAEAVLGMFKQAGFTGCFTAKDLNGIDRVVGGRIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YS0</accession>
    <name>Q39YS0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512333.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0361"/>
    <dbReference type="DNASU" id="3739727"/>
    <dbReference type="EnsemblBacteria" id="ABB30604">
        <property type="protein sequence ID" value="ABB30604"/>
        <property type="gene ID" value="Gmet_0361"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0361"/>
    <dbReference type="eggNOG" id="COG0300">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_2_6_7"/>
    <dbReference type="OMA" id="MEITPTL"/>
    <dbReference type="OrthoDB" id="1582456at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="244" mass="25294" checksum="4A2DF81C1055D760" modified="2005-11-22" version="1">MDLKGKTVLVTGANGGIGGALVRTLLDKGVAKVYAAARSIDAVADLAHGGDDRVVALRLDVTQAASVAGTAEQCRDVDLIINNAGVNRCTGFMSPTTLEDARLEMEVNYFGTLAMCRAFAPVLASRGGGAIVNVCSIIGLVNLPVNGTYCASKAAGHSLLQGLRAELAPGAIRVIGVYPGPVDTKMTAGQEMPKATTEQVAAAILAGVEKGDEYIFPDPMSQHVHAMLEKDPRQVERDFGAMAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YT3</accession>
    <name>Q39YT3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, M1 superfamily, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30591.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512319.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0348"/>
    <dbReference type="EnsemblBacteria" id="ABB30591">
        <property type="protein sequence ID" value="ABB30591"/>
        <property type="gene ID" value="Gmet_0348"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0348"/>
    <dbReference type="eggNOG" id="COG0308">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014353_0_0_7"/>
    <dbReference type="OMA" id="EIAHCWW"/>
    <dbReference type="OrthoDB" id="771837at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase_M1" evidence="1">
        <location>
            <begin position="292"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30591.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="690" mass="74684" checksum="A47013F85B1FA061" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YU3</accession>
    <name>Q39YU3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heme-binding sensor globin domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512310.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0338"/>
    <dbReference type="EnsemblBacteria" id="ABB30581">
        <property type="protein sequence ID" value="ABB30581"/>
        <property type="gene ID" value="Gmet_0338"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0338"/>
    <dbReference type="eggNOG" id="COG3431">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080697_0_0_7"/>
    <dbReference type="OMA" id="IGLPTHY"/>
    <dbReference type="OrthoDB" id="1582767at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044398">
        <property type="entry name" value="Globin-sensor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020948">
        <property type="entry name" value="P_starv_induced_PsiE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11563">
        <property type="entry name" value="Protoglobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06146">
        <property type="entry name" value="PsiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="SSF46458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Protoglobin" evidence="3">
        <location>
            <begin position="3"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="300" mass="34409" checksum="32D1C222BFBF8C62" modified="2005-11-22" version="1">MYSMQEIKAHYLFGDEDAETLKSLLSIAQANRELMIEDFYDYLLGIPETAAFLQDDTVLQRLKLSHGGWFVNLFRGVYDNQYLHDLQRVGHVHVKIGLNAHFVNAAMQKVRRFAVGMIRENFPDRDERRKKTEAVEKILDINLDIMTASYIEEELKKVFISKRLESLLVRATERFTYGLNLVLVLALVGVSLSVVGLFFWEIFHVFRGSVEKGILSALGTLLILWMMIELMDNEIKTLKGGRFNIQVFIGVVIIAIIREILISTLRHDPLETQVFLAGTLMVLGVVYYLVARSQQISPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YV1</accession>
    <name>Q39YV1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Respiratory nitrate reductase, iron-sulfur cluster-binding beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">narH-1</name>
        <name evidence="3" type="ordered locus">Gmet_0330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512302.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0330"/>
    <dbReference type="EnsemblBacteria" id="ABB30573">
        <property type="protein sequence ID" value="ABB30573"/>
        <property type="gene ID" value="Gmet_0330"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0330"/>
    <dbReference type="eggNOG" id="COG1140">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_5_2_7"/>
    <dbReference type="OMA" id="CNACAHS"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042126">
        <property type="term" value="P:nitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029263">
        <property type="entry name" value="Nitr_red_bet_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038262">
        <property type="entry name" value="Nitr_red_bet_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006547">
        <property type="entry name" value="NO3_Rdtase_bsu"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14711">
        <property type="entry name" value="Nitr_red_bet_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01660">
        <property type="entry name" value="narH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="2">
        <location>
            <begin position="204"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="484" mass="54136" checksum="3F40CB9E721B6CA2" modified="2005-11-22" version="1">MDVRAQLVMVFNLDKCIGCHACSLSCKNIWTDRKGAEYMWWNNVETKPGVGYPKKWEDQEEFKGGWVADGHNLRLKAMGKGPTLLNMFFQPNMPKLEDYYEPFDFDYGNLYGAKGGDDQPVAEAFSQITGEKMAHIKAGPNWDDDLSGSQVYASADVNLEDKKIIEQYSTMFMQYLPRICNHCANPACVASCPSRAIYKRGEDGVVLVDQEVCKGWRFCTSACPYKKVYFNWNSGKAEKCIFCFPRTETGQCNACAHSCVGRIRYVGVLLYDAEKVEQALLKPDNQLVEAHRGVILDPRDEAVREGARKNGVPEQWLEAAEKSPVYALIKEFELALPLHPEFRTMPMAYYIPSLSPVLTSGGELHELVEHGTIPTREALRAPIGYLASLFGGGNRDVVAAALEKLIALRIHMRAKNLNQPTDEASLGKAGLDEAGAKRLYRLFTIGGYNERNIIPPQQREELDSHTRKGASGFGILKKTGRGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YY2</accession>
    <name>Q39YY2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">yccM-2</name>
        <name evidence="6" type="ordered locus">Gmet_0297</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514008.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0297"/>
    <dbReference type="EnsemblBacteria" id="ABB30542">
        <property type="protein sequence ID" value="ABB30542"/>
        <property type="gene ID" value="Gmet_0297"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0297"/>
    <dbReference type="eggNOG" id="COG0348">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033147_0_0_7"/>
    <dbReference type="OMA" id="DAPYWAV"/>
    <dbReference type="OrthoDB" id="1230380at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12801">
        <property type="entry name" value="Fer4_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="335" mass="36950" checksum="F962071090C812D6" modified="2005-11-22" version="1">MNKPNFHSRIPTWRALVQWGFFAWVVVIGIRFGAFVRHFETGGATPLVTRPPGVEGFLPIGALASTKLWLATGTVNPVHPAALVIFLTIVGMSLVAKKSFCSWLCPVGTLSEAAWKLGQRLFGRNFRVWPWLDAALRGVKYLLLLFFVKLILIDMPALALSAFLDAPYWAVSDVKMLHFFTRMSVTTVVVLAVLTGLSLLYRNAWCRYLCPYGALLGVASYLSPFKIRRDTAGCTGCRGCSRACPSGLPVHEKETVISAECTGCLTCVASCPERDVLRMAPPFWRRPLPAWVFPALVVLLFVAGIGTGMATGNWHSSLSADDYRRLIPMVPYLSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z06</accession>
    <name>Q39Z06_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type VI secretion system inner membrane protein TssL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tssL</name>
        <name evidence="3" type="ordered locus">Gmet_0273</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513590.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0273"/>
    <dbReference type="EnsemblBacteria" id="ABB30518">
        <property type="protein sequence ID" value="ABB30518"/>
        <property type="gene ID" value="Gmet_0273"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0273"/>
    <dbReference type="eggNOG" id="COG3455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071818_4_0_7"/>
    <dbReference type="OMA" id="REVYYLC"/>
    <dbReference type="OrthoDB" id="1650600at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017732">
        <property type="entry name" value="T4/T6SS_DotU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038522">
        <property type="entry name" value="T4/T6SS_DotU_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09850">
        <property type="entry name" value="DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03349">
        <property type="entry name" value="IV_VI_DotU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="DotU" evidence="2">
        <location>
            <begin position="3"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="226" mass="25621" checksum="A05025F42E85F452" modified="2005-11-22" version="1">MHLTDCFTELVAYVTHFLRTAAVRQPSYQEVRREIDLLLASGESCVRREGFSRDDFELARFAVCAWIDEAVLSSAWSEKSLWLREQLQRLHYNTTEAGEEFFTRLNALGLHQREVREVYYLCLALGFTGRFCKPGDEYQLEQVKTAQLKLLVGSSVGLPSLERTELFPEAYPAGAPAMAPARRRVGFSPLAAVCLAGPAVFFVILFFVYRFTLSGVGENFLRTVPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z37</accession>
    <name>Q39Z37_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-glucose--undecaprenyl-phosphate glucosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0242</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0242"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30487">
        <property type="protein sequence ID" value="ABB30487"/>
        <property type="gene ID" value="Gmet_0242"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0242"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033536_9_0_7"/>
    <dbReference type="OMA" id="MVNTDAV"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="2">
        <location>
            <begin position="12"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="253" mass="27752" checksum="38C21A571666C6E7" modified="2005-11-22" version="1">MSGGPVKTPFLSFIIPAYNEEQRLPSYLERVIGFFAGQSYSFEIVVVDDGSSDGTAALVKALMAQHSCLRLEALDRNRGKGFAVKTGMSAAKGQLRVFADADGATPVEEIRRLLDAREQGADIAIGSRAMRSDECIVQGRVHRKIMGTVFNGLIRALAVRGIHDSQCGFKLFTASAAEDIFPRQRITGFGFDVELLFLARRLGYVVVEVPVNWSDVEGTKVRLVRDSFRMLGEVLRIRFTNLTGGYGDIPGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z48</accession>
    <name>Q39Z48_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone oxidoreductase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513546.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0231"/>
    <dbReference type="EnsemblBacteria" id="ABB30476">
        <property type="protein sequence ID" value="ABB30476"/>
        <property type="gene ID" value="Gmet_0231"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0231"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_1_7"/>
    <dbReference type="OMA" id="NHICTIR"/>
    <dbReference type="OrthoDB" id="831053at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="320" mass="33736" checksum="D723A16361341AB8" modified="2005-11-22" version="1">MKAIRVREFGEPEVMGLEDVAPLTPGPAEVVVRLHAVGVNPVDAYIRSGQYRPDLKLPYTPGLDGAGVISAVGSEVKHRHVGQRVYVAWSLSGTYAEEVLCKEFQTHPLPDGVSFAQGAAIGVPYGAAFRALFQRAHAVAGETVLIHGASGGVGIAAVQLARRAGMWVIGTAGTEKGEALVRAQGAHHVLNHRVEGYLDRLQEFPCGKGVDVIVEMLANVNLDRDLGVLAKGGRVVVVGSRGRVEIDPRTAMGKEAAILGMTLYNASDKELAGMHAAFVEGLANGTLRPVVSRELPLAAAAEAHHAVMESSTFGKIVLLP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z75</accession>
    <name>ARGB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetylglutamate kinase</fullName>
            <ecNumber evidence="1">2.7.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-L-glutamate 5-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NAG kinase</fullName>
            <shortName evidence="1">NAGK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argB</name>
        <name type="ordered locus">Gmet_0203</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetylglutamate kinase family. ArgB subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512792.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z75"/>
    <dbReference type="SMR" id="Q39Z75"/>
    <dbReference type="STRING" id="269799.Gmet_0203"/>
    <dbReference type="PRIDE" id="Q39Z75"/>
    <dbReference type="EnsemblBacteria" id="ABB30449">
        <property type="protein sequence ID" value="ABB30449"/>
        <property type="gene ID" value="Gmet_0203"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0203"/>
    <dbReference type="eggNOG" id="COG0548">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053680_0_0_7"/>
    <dbReference type="OMA" id="EGLYEDW"/>
    <dbReference type="OrthoDB" id="901370at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04250">
        <property type="entry name" value="AAK_NAGK-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00082">
        <property type="entry name" value="ArgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037528">
        <property type="entry name" value="ArgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041727">
        <property type="entry name" value="NAGK-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000728">
        <property type="entry name" value="NAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000264710" description="Acetylglutamate kinase">
        <location>
            <begin position="1"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="29"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00082"/>
        </source>
    </evidence>
    <sequence length="292" mass="31170" checksum="F30EDB50C125C29C" modified="2005-11-22" version="1">MQHLIEKANTLMEALPYIRRFSGKTIVIKYGGHAMSDEALKKSFALDVILLKSLGINTVVVHGGGPQINETLKRYGIVSEFVRGMRVTDAATMQVVEMVLTGQVNKEVVGYLNQHGGRAVGLSGKDGSLLLCRKLLQEVKQGDGSLEKVDIGFVGDVVKVNQELIQTLEHGKFIPVIAPVGVGEDGESYNVNADLVAGRVAGALKAEKLILLTDVEGVKDKAGELIPGIVLDDVPRLIDGGVITGGMIPKVTCCVDAIEEGVKKASIIDGRVLHAVLLEIFTDVGVGTEIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z93</accession>
    <name>Q39Z93_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Recombination-associated protein RdgC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in recombination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Nucleoid</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RdgC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512774.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0185"/>
    <dbReference type="EnsemblBacteria" id="ABB30431">
        <property type="protein sequence ID" value="ABB30431"/>
        <property type="gene ID" value="Gmet_0185"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0185"/>
    <dbReference type="eggNOG" id="COG2974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709501_0_0_7"/>
    <dbReference type="OMA" id="CREHYLM"/>
    <dbReference type="OrthoDB" id="378364at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009295">
        <property type="term" value="C:nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007476">
        <property type="entry name" value="RdgC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04381">
        <property type="entry name" value="RdgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="388" mass="43485" checksum="2681009F16B30B01" modified="2005-11-22" version="1">MGILSGTVAVCQFRVAGDLPSGDLYPFIAENLAKQAFQPIDQGAAEQSVGWVHLDDHRQMSFDTTAAFWRDHYVTFTLRRDQRKLPAALVKAYLQVAEHEHLSANPGLNRVPKQKREELKEAVRLSLLAKTLPVPSTWDAVWDTRTGIVSFTSLSAPIIELFEAQFKKTFEGARLVAIHPYSRAEAVVGEELQPALEKSNLATSDAAIDLIRSNQWLGWDFLLWLLHRTMTEASEYRVSRPGPALADDPFVAYLNDRLVLMSAGEAGTQKITVAGPQDHFREARTALAHGKRITESTLYLEQEENAWKLTLKGELFHFASFKAPKVAIEKGDHVDEGSEREAAFYERMYVIEQGLQLFDSLYGEFLKARLGAGWGEELARIEGWLAGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-13" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZB6</accession>
    <name>NUOH1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit H 1</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit H 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit H 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoH1</name>
        <name type="ordered locus">Gmet_0161</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I subunit 1 family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512748.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZB6"/>
    <dbReference type="SMR" id="Q39ZB6"/>
    <dbReference type="STRING" id="269799.Gmet_0161"/>
    <dbReference type="EnsemblBacteria" id="ABB30408">
        <property type="protein sequence ID" value="ABB30408"/>
        <property type="gene ID" value="Gmet_0161"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0161"/>
    <dbReference type="eggNOG" id="COG1005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_0_1_7"/>
    <dbReference type="OMA" id="FTWVERR"/>
    <dbReference type="OrthoDB" id="1559067at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016655">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01350">
        <property type="entry name" value="NDH1_NuoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018086">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11432">
        <property type="entry name" value="PTHR11432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00668">
        <property type="entry name" value="COMPLEX1_ND1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000240074" description="NADH-quinone oxidoreductase subunit H 1">
        <location>
            <begin position="1"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01350"/>
        </source>
    </evidence>
    <sequence length="329" mass="36323" checksum="E18F5744AB0DF942" modified="2005-11-22" version="1">MTPVALDIAIHLAKIALIFFVVLTLAAYLVFAERRILAWIQDRKGPNRVGPFGLLQPLADLIKLLTKEDFRPAGADKWLFYLAPAMAAIPAILTFAVIPFGAPLTLFGREVPLQVADLNVGLLFFLALSSIAVYGVALGGWASNSKYALLGSIRGLAQLISYELSMGLSLVPTVMLAGSLRLSDIVAAQEGIWFIVYQPLAFVIFLISIAAECKRIPFDIPEAEGELVAGFHTEYSGMRFGLFFVGEYINIIVLGGLATTFFLGGWHGPWLPPFVWFSAKTLAFAFFFIWMRGTLPRLRYDQLMHLGWKVLTPLALVNILVTGWILMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZC2</accession>
    <name>Q39ZC2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0155</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome c family. PetJ subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512742.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0155"/>
    <dbReference type="EnsemblBacteria" id="ABB30402">
        <property type="protein sequence ID" value="ABB30402"/>
        <property type="gene ID" value="Gmet_0155"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0155"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101159_3_0_7"/>
    <dbReference type="OMA" id="KAKFDQH"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023655">
        <property type="entry name" value="Cyt_C6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34688">
        <property type="entry name" value="PTHR34688"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223340" evidence="6">
        <location>
            <begin position="21"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="7">
        <location>
            <begin position="28"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="110" mass="11770" checksum="6D878D92490257C4" modified="2005-11-22" version="1">MKKGIIISISLLATAAFATAGLADTKKGGKIDGAKEFKEHCAVCHPDGGNIVNPAKPLKKATLEANGVKTWKDIVAKMRNPGPGMTKFEKKDVSDKEARAIAEYVLKTFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZP2</accession>
    <name>Q39ZP2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SpoVR-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30282.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365619.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0032"/>
    <dbReference type="EnsemblBacteria" id="ABB30282">
        <property type="protein sequence ID" value="ABB30282"/>
        <property type="gene ID" value="Gmet_0032"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0032"/>
    <dbReference type="eggNOG" id="COG2719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010179_1_0_7"/>
    <dbReference type="OMA" id="NSNPCYA"/>
    <dbReference type="OrthoDB" id="507759at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007390">
        <property type="entry name" value="Spore_V_R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30029">
        <property type="entry name" value="PTHR30029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04293">
        <property type="entry name" value="SpoVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30282.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="542" mass="63904" checksum="44083A4358BEB810" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PV9</accession>
    <name>Q39PV9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513666.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3510"/>
    <dbReference type="EnsemblBacteria" id="ABB33715">
        <property type="protein sequence ID" value="ABB33715"/>
        <property type="gene ID" value="Gmet_3510"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3510"/>
    <dbReference type="eggNOG" id="ENOG50349K4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119465_0_0_7"/>
    <dbReference type="OMA" id="HRTVMAI"/>
    <dbReference type="OrthoDB" id="1538707at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223128" evidence="2">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="197" mass="21386" checksum="2CC0BE72A89F61FF" modified="2005-11-22" version="1">MNRITMTVLAVVTLAILGGCAGTAELARTAAIATRQDVFVEKAQGQSLPPGYAELRVVSSLKTHGPEIYSRRDVHGTPEYKLLLNIGGQTAELSGDPRPERSEPLGLRDPEAGEGMRYRFTQTLYVKAGTHHMVVALPADNVATEREIILPEGSSTTIVLEPGYGTASPRRRPSSYTVTDFREGIRALRVVLNDETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q01</accession>
    <name>Q39Q01_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux pump, RND family, membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ybhG-2</name>
        <name evidence="2" type="ordered locus">Gmet_3464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513915.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3464"/>
    <dbReference type="EnsemblBacteria" id="ABB33673">
        <property type="protein sequence ID" value="ABB33673"/>
        <property type="gene ID" value="Gmet_3464"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3464"/>
    <dbReference type="eggNOG" id="COG1566">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_6_3_7"/>
    <dbReference type="OMA" id="NTKYPGR"/>
    <dbReference type="OrthoDB" id="1174564at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HlyD_D23" evidence="1">
        <location>
            <begin position="45"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="335" mass="36757" checksum="EC847470A12EE623" modified="2005-11-22" version="1">MKRKLILLILVVVIAGVAAFFLLNRKKDDTGILLSSGNVEVTEVDLGFKVPGRVERLLTDEGRKVVAGEAVAVLDRSELLRQMEAQRAVIDASSARLLELQHGSRPQEKRSARAMVASASADLEKAVKDLERAETLFRNGAIAAQQRDVAKRSFEVAKAQQDHAVQNESLVKEGPRLETIRATEAQVRQAGAQLGVYREQLADMELKTPVKGVVLRKNVEAGETVTAGTPIFTVGELEHPWVKIYVKEDKLGLVKLGQKAEVTVDTYPGRKFAGVVTYISSEAEFTPKNVQTQEERVKLVFGVKVSVDNPNQELKPGMPADVRIVTGDRESGTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q51</accession>
    <name>Q39Q51_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">F-type ATPase subunit b</fullName>
            <shortName evidence="13">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">atpF</name>
        <name evidence="16" type="synonym">atpX</name>
        <name evidence="16" type="ordered locus">Gmet_3411</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="16 17" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0). The b'-subunit is a diverged and duplicated form of b found in plants and photosynthetic bacteria.</text>
    </comment>
    <comment type="function">
        <text evidence="11 13">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cell inner membrane</location>
            <topology evidence="13">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13 14">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514218.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3411"/>
    <dbReference type="EnsemblBacteria" id="ABB33623">
        <property type="protein sequence ID" value="ABB33623"/>
        <property type="gene ID" value="Gmet_3411"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3411"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079215_9_3_7"/>
    <dbReference type="OMA" id="PLMAIQF"/>
    <dbReference type="OrthoDB" id="1999641at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="13" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="13" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0138">CF(0)</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 13 14" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 13 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 13 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="ABB33623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="141" mass="15650" checksum="06293629D05B5DE9" modified="2005-11-22" version="1">MISLDLAFVIQFVNFLVLLLVLNIFLYKPIRKIMADRKAQIDGAKERAAAVDKDVQEKMALYEARLREIKAKANAERETLRSGALQEEAAVIEKARKEAADSLSSIKNRVAQEAAAAKQLLAEQARALSLEISEKVLGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QA1</accession>
    <name>Q39QA1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable cytosol aminopeptidase</fullName>
            <ecNumber evidence="8">3.4.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucine aminopeptidase</fullName>
            <shortName evidence="8">LAP</shortName>
            <ecNumber evidence="8">3.4.11.10</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Leucyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 10" type="primary">pepA</name>
        <name evidence="10" type="ordered locus">Gmet_3361</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.</text>
            <dbReference type="EC" id="3.4.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.</text>
            <dbReference type="EC" id="3.4.11.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="8">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the peptidase M17 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.1" evidence="8"/>
    <dbReference type="EC" id="3.4.11.10" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512587.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3361"/>
    <dbReference type="EnsemblBacteria" id="ABB33573">
        <property type="protein sequence ID" value="ABB33573"/>
        <property type="gene ID" value="Gmet_3361"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3361"/>
    <dbReference type="eggNOG" id="COG0260">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013734_2_2_7"/>
    <dbReference type="OMA" id="MKNTGPR"/>
    <dbReference type="OrthoDB" id="356206at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00181">
        <property type="entry name" value="Cytosol_peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023042">
        <property type="entry name" value="Peptidase_M17_leu_NH2_pept"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008283">
        <property type="entry name" value="Peptidase_M17_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="PTHR11963"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02789">
        <property type="entry name" value="Peptidase_M17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="SSF52949"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CYTOSOL_AP" evidence="9">
        <location>
            <begin position="344"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="350"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="496" mass="53126" checksum="4070E5683EAEE465" modified="2005-11-22" version="1">MNARVVLHDALLYPCPLLVLGCYEDRFSENTLLGSVDDALGRGLSAIREAGEFTGKLNRTKLIHTLGRLPAERLLLVGLGQRDAVTPERVRQAAGSAVKAVRATGVVRFATILHRSADSVPGSLEASLEGYLLGGYGFDIYKTTKNDEGTVEEMAVLVDEEGELASTERAVSERTTVCDAVSFVRDLVSHPCNVATPAYLADRAIEMAGRLGVACRVLEREDMERLSMEGILSVAKGSHHSPRFIILEYLAGDPKKRPVVLVGKGVTFDSGGISLKPREGMERMKDDMAGAAAVMGTISAVSGLRMPVNVVGLIPVAENMPGGGAYRPGDVVRTMSGQTVEIVNTDAEGRMLLCDALYYAQRYRPAALIDLATLTGACLVALGTVATAVMGNDSTLIRALTTSGEATGERLWELPVWDEYGELMKSDIADMKNAGGPHAGTISAAWFLQRYVGKAKWAHLDIAGTAWEEKGKPYLPKGATGVGVRLLVEYLQRTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QI5</accession>
    <name>Q39QI5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT-like repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366173.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3276"/>
    <dbReference type="EnsemblBacteria" id="ABB33489">
        <property type="protein sequence ID" value="ABB33489"/>
        <property type="gene ID" value="Gmet_3276"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3276"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_503296_0_0_7"/>
    <dbReference type="OMA" id="RWYVVRN"/>
    <dbReference type="OrthoDB" id="1291205at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="557" mass="59807" checksum="31E6A79FB102D58A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QP5</accession>
    <name>Q39QP5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366162.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3216"/>
    <dbReference type="EnsemblBacteria" id="ABB33429">
        <property type="protein sequence ID" value="ABB33429"/>
        <property type="gene ID" value="Gmet_3216"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3216"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_432619_0_0_7"/>
    <dbReference type="OMA" id="GYYERVL"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="12"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223165" evidence="3">
        <location>
            <begin position="27"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="64"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="199"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="267"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="335"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="403"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="437"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="471"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="539"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="643" mass="70831" checksum="F605A9ABE2787CCC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QQ4</accession>
    <name>Q39QQ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane lipoprotein carrier/sorting protein LolA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512645.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3207"/>
    <dbReference type="EnsemblBacteria" id="ABB33420">
        <property type="protein sequence ID" value="ABB33420"/>
        <property type="gene ID" value="Gmet_3207"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3207"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087560_2_2_7"/>
    <dbReference type="OMA" id="GLMRWEY"/>
    <dbReference type="OrthoDB" id="1933827at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35869">
        <property type="entry name" value="PTHR35869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223427" evidence="2">
        <location>
            <begin position="25"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="242" mass="26154" checksum="9374F4B3EB015910" modified="2005-11-22" version="1">MIFRRLLPCLVAALMTVAPTLAAAASVSEVVTALEKGYASLRDLQASFTQRSELASVKKAQTGSGEVFIRKGSGAGAMFRFNYTKPRQEIISNGKKVWYYLPENRQVMTMDAASLFAGGGGVALSYLTGMGEVSRDFTVRFVGDGKDARGNYVLELVPKKPGQAFQKLHLTVSGRAVEEYLAQGRASMPFPIVSSVVFDQMGNRTAIEFSKVKVNRGVKASLFTFTPPPGVEVIQNPMGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="42" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QX4</accession>
    <name>Q39QX4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3137"/>
    <dbReference type="EnsemblBacteria" id="ABB33350">
        <property type="protein sequence ID" value="ABB33350"/>
        <property type="gene ID" value="Gmet_3137"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3137"/>
    <dbReference type="HOGENOM" id="CLU_2382023_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="94" mass="11015" checksum="27B05614FE81943E" modified="2005-11-22" version="1">MGKFTLYSLTWYWTMQRASVKLGIFVTMREPTRGILGTVQCYGYYDYQLSENLPVQRIPSIHVLSEEQFFRGKYPHELLLPHRGTVGNTRRAIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R05</accession>
    <name>Q39R05_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Basal-body rod modification protein FlgD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">flgD</name>
        <name evidence="8" type="ordered locus">Gmet_3105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Required for flagellar hook formation. May act as a scaffolding protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the FlgD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514280.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3105"/>
    <dbReference type="EnsemblBacteria" id="ABB33319">
        <property type="protein sequence ID" value="ABB33319"/>
        <property type="gene ID" value="Gmet_3105"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3105"/>
    <dbReference type="eggNOG" id="COG1843">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047535_0_1_7"/>
    <dbReference type="OMA" id="STYAHVT"/>
    <dbReference type="OrthoDB" id="709873at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005648">
        <property type="entry name" value="FlgD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025965">
        <property type="entry name" value="FlgD_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025963">
        <property type="entry name" value="FLgD_Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03963">
        <property type="entry name" value="FlgD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13860">
        <property type="entry name" value="FlgD_ig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13861">
        <property type="entry name" value="FLgD_tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FLgD_tudor" evidence="7">
        <location>
            <begin position="81"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="FlgD_ig" evidence="6">
        <location>
            <begin position="96"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="218" mass="22679" checksum="18F3AE995806FA13" modified="2005-11-22" version="1">MVNGITTDTTAAAAAMKKSTGMNKDDFLKLFVTQLQHQDPLNPADSSEFIGQLAQLTQVEQAYNTNSNLTKIIDLFNGATSLSSVSYIGKSVTANGDQINLTAGSKPALGYRLPADAQQVAINISDISGTVVRTLNLGNTRAGDGTILWDGRNGNGSTLPAGQYSFSVTGYNAKGEKFQGNPLLVGTVEGITLEGKEPNVTIGGISVPLSNVLSVKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R33</accession>
    <name>Q39R33_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3077</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513636.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3077"/>
    <dbReference type="EnsemblBacteria" id="ABB33291">
        <property type="protein sequence ID" value="ABB33291"/>
        <property type="gene ID" value="Gmet_3077"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3077"/>
    <dbReference type="eggNOG" id="COG4118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163140_2_1_7"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="86" mass="9414" checksum="0E0A361093E3BB3C" modified="2005-11-22" version="1">MIAVGIKELKARLSSYVEKVQQGEEVVITDHGREVALVVPISPERRAVKTLMTEGRAKWSGGKPAGKRGVTLKGESLSDTVLEERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R34</accession>
    <name>Q39R34_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease VapC</fullName>
            <shortName evidence="5">RNase VapC</shortName>
            <ecNumber evidence="5">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Toxin VapC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">vapC</name>
        <name evidence="7" type="ordered locus">Gmet_3076</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Toxic component of a toxin-antitoxin (TA) system. An RNase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PINc/VapC protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513635.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3076"/>
    <dbReference type="EnsemblBacteria" id="ABB33290">
        <property type="protein sequence ID" value="ABB33290"/>
        <property type="gene ID" value="Gmet_3076"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3076"/>
    <dbReference type="eggNOG" id="COG1848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_119496_1_2_7"/>
    <dbReference type="OrthoDB" id="1968541at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00265">
        <property type="entry name" value="VapC_Nob1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022907">
        <property type="entry name" value="VapC_family"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01850">
        <property type="entry name" value="PIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="SSF88723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0800">Toxin</keyword>
    <keyword evidence="1 5" id="KW-1277">Toxin-antitoxin system</keyword>
    <feature type="domain" description="PINc" evidence="6">
        <location>
            <begin position="4"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="6"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="142" mass="15597" checksum="9AF40CFF2B3CFD16" modified="2005-11-22" version="1">MILYLDTSSLVKLYVEEVCSDTVRQWVESAEAVATCRVAYPEMLSALTRRHNRGDLPREDCEVVAECFAGEWEHFVALDFDEIEAGHLVRKYGLRGFDAVHLAAAKLLSNDCGAIEVAFSSFDNKLNGAAEAEGFALLAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R91</accession>
    <name>Q39R91_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rhodanese homology domain superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3018</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514332.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3018"/>
    <dbReference type="EnsemblBacteria" id="ABB33233">
        <property type="protein sequence ID" value="ABB33233"/>
        <property type="gene ID" value="Gmet_3018"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3018"/>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089574_8_0_7"/>
    <dbReference type="OMA" id="IAYCNGF"/>
    <dbReference type="OrthoDB" id="2056793at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="75"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="172" mass="18210" checksum="30C03A5B2F2B4C20" modified="2005-11-22" version="1">MKSDAKRLAAEMAAIVLIAAVIGIAWNHRLLLNVFRGEGVKAQQTPAAPKGAPAAAPTAAAALPLGLMQVKELFDTGEAIIIDARDREAYRKGHIKGAMSLPVGEAGGLITPFADRTPKDKLLVVYCGGYDCHDSKLLGEKLLAAGFTQVFVYEGGYPEWQDAGHPVTKGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R95</accession>
    <name>Q39R95_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Outer membrane protein assembly factor BamD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">yfiO</name>
        <name evidence="1" type="synonym">bamD</name>
        <name evidence="4" type="ordered locus">Gmet_3014</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the Bam complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the BamD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514328.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3014"/>
    <dbReference type="EnsemblBacteria" id="ABB33229">
        <property type="protein sequence ID" value="ABB33229"/>
        <property type="gene ID" value="Gmet_3014"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3014"/>
    <dbReference type="eggNOG" id="COG4105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065982_2_1_7"/>
    <dbReference type="OMA" id="VERQHPY"/>
    <dbReference type="OrthoDB" id="1256747at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043165">
        <property type="term" value="P:Gram-negative-bacterium-type cell outer membrane assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051205">
        <property type="term" value="P:protein insertion into membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00922">
        <property type="entry name" value="OM_assembly_BamD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017689">
        <property type="entry name" value="BamD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039565">
        <property type="entry name" value="BamD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13525">
        <property type="entry name" value="YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03302">
        <property type="entry name" value="OM_YfiO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5009019136" description="Outer membrane protein assembly factor BamD" evidence="1">
        <location>
            <begin position="28"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="YfiO" evidence="3">
        <location>
            <begin position="37"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="249" mass="28729" checksum="8123427C4C0EEDC8" modified="2005-11-22" version="1" precursor="true">MNRIQRRSLFPLLLVLVVAGCATTPDAVSRNPESMAKAAEEFQTSGRYEDAIAQWKKVRESYASPELTTEAELKIADAQFADKSYIEAAASYEEFRKLHPNHEKAPYALYRQALSQYEQITGIDTDQTPVSNAVTLFESFLRIYPSSEYAAEVRDKLEVCRLKQVEHEIYVGRFYYRTDQYGAAIKRLEDALKKYPRSPAHDETLFYLGSAYIRTGDKAKGRDAFQRLFAEYRTSKYVDEARKFMDKNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RC0</accession>
    <name>Q39RC0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix iron-sulfur cluster-binding transcriptional regulator IscR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iscR-1</name>
        <name evidence="1" type="ordered locus">Gmet_2989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514480.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2989"/>
    <dbReference type="EnsemblBacteria" id="ABB33204">
        <property type="protein sequence ID" value="ABB33204"/>
        <property type="gene ID" value="Gmet_2989"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2989"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_0_1_7"/>
    <dbReference type="OMA" id="FDIAYNA"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030489">
        <property type="entry name" value="TR_Rrf2-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01332">
        <property type="entry name" value="HTH_RRF2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="154" mass="17568" checksum="1BFB4CA4949B168F" modified="2005-11-22" version="1">MKLSTKSRYGLRAIFDIAYNSGNLPSQVQDISRRQGISPRYLEQIFQGLKRAGILKSKRGPQGGYCLAKKPEEITVADVLLATERDMNLVECTNKRKKKVECGFDGTCVTQELWCEASSRLVEYFSAITVKDLCDRGQSMGIKREQDHRFMYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RF7</accession>
    <name>Q39RF7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512885.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2949"/>
    <dbReference type="EnsemblBacteria" id="ABB33167">
        <property type="protein sequence ID" value="ABB33167"/>
        <property type="gene ID" value="Gmet_2949"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2949"/>
    <dbReference type="eggNOG" id="COG2510">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060016_2_0_7"/>
    <dbReference type="OMA" id="GYIAWLM"/>
    <dbReference type="OrthoDB" id="1503557at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="2">
        <location>
            <begin position="158"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="290" mass="32227" checksum="204F660A27B2ACBE" modified="2005-11-22" version="1">MSTLAFTLIVISAVMHALWNLLVKRSRHKTVFIWWMFVASSSLFTLTIPFLPERFRWPDPATLLLVTAGAVCFVLYHLLNGRAYRGGDLSVVYPLSQTSMVYVPIWGMSILGERLTMPGIAGILLVILGAFSVQMERLSLAEFLRPFRNLGSPTVRNALAAGFIYSLGSIAEKVGVRDYTPLYFTYFLVLIMLGLMSVNLLRPCYRPLIVAEFREHWPLILVSGPVMMASFLTFRYGLNLSPMSYAVPVRQVSILMGVLIGILFLGESCGRIRLGAALVILAGAIMIRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RH6</accession>
    <name>Q39RH6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Menaquinol oxidoreductase complex Cbc5, cytochrome c subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cbcC</name>
        <name evidence="3" type="ordered locus">Gmet_2930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512866.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2930"/>
    <dbReference type="EnsemblBacteria" id="ABB33148">
        <property type="protein sequence ID" value="ABB33148"/>
        <property type="gene ID" value="Gmet_2930"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2930"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073018_0_0_7"/>
    <dbReference type="OMA" id="CHNAKEA"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026352">
        <property type="entry name" value="Nanowire_3heme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039118">
        <property type="entry name" value="QrcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39425">
        <property type="entry name" value="PTHR39425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04257">
        <property type="entry name" value="nanowire_3heme"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223295" evidence="1">
        <location>
            <begin position="23"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="39"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="119"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="193"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="266"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="329" mass="35648" checksum="8AF59A8CEBC89A66" modified="2005-11-22" version="1">MRFRFTLPLVACTLAVAGLAFGISIKDVVFTTKDAGKIVFSHKVHIGKKGIENNCKACHPAIFDMKKKVTYTMADMEKGKSCGACHTGKDGVFPLKDCARCHAVKEITYQVKSAGPTPFSHKKHLAKYSDCGACHPKLFKAGHNKPVTMAEMEKGKSCGACHNGKSAFSVNECARCHLVKEVGLTSKETGKIIFSHKLHAAKRKCGECHNKLYEAGRNKPVGMAAMEKGKSCGACHNGKGLFDVKQCAKCHPVKAVNFKVSGAGPVKFSHDVHLAMYSCNACHTKIFKAGRSAKVVTMFEMEKGKSCGACHDGKKAFSVREDCVKCHDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RK5</accession>
    <name>Q39RK5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ResB-like family cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2901</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512837.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2901"/>
    <dbReference type="EnsemblBacteria" id="ABB33119">
        <property type="protein sequence ID" value="ABB33119"/>
        <property type="gene ID" value="Gmet_2901"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2901"/>
    <dbReference type="eggNOG" id="COG1333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034630_1_0_7"/>
    <dbReference type="OMA" id="RFWIDYT"/>
    <dbReference type="OrthoDB" id="1518243at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="19"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="362"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="452" mass="50476" checksum="C13CE67F69AC1B2A" modified="2005-11-22" version="1">MTTSNRGFLETLWDFFCSLKLAISLLILLAATSIIGTIIPQGPPPPEYLQTISEGKHKFYQALGFFDMYHSWWFILLLYLFTVNIVACSIKRLPRVWKAISEPTLVMDDKFEKTLSLTHDFKMNGDAASLRDKMVAFLKGEFAAPVVTERDGEFHLFAQKTPYSRLGVYVVHLSIIVIFIGALIGSFFGYKAYVEIAEGTSTSVVHNRADMKPIDLGFTVRCDKFTVSYYDTGAPKEFKSLLTVIDGGKVVFDKRPVIVNDPLTYKGITFYQASYRPAEGAGLYFFTVRERKGGAPAKISIQQGERKVLSDGSTMQVLEVAQEVSKFIPQFQGPAARIEVTPKGGGAPQVFIVFQNYPEFDAQRGGDLIFSYDGSEEKMFTGLQVAKDPGVWVVWAGCFLMVAGCCMAFFMSHRRIWIRVRKGEVTLGGSANKNQPGFQLAFDALVDKLKQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RQ9</accession>
    <name>RL25_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L25</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">General stress protein CTC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplY</name>
        <name evidence="1" type="synonym">ctc</name>
        <name type="ordered locus">Gmet_2847</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514569.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RQ9"/>
    <dbReference type="SMR" id="Q39RQ9"/>
    <dbReference type="STRING" id="269799.Gmet_2847"/>
    <dbReference type="EnsemblBacteria" id="ABB33065">
        <property type="protein sequence ID" value="ABB33065"/>
        <property type="gene ID" value="Gmet_2847"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2847"/>
    <dbReference type="eggNOG" id="COG1825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075939_2_1_7"/>
    <dbReference type="OMA" id="HVDFYEV"/>
    <dbReference type="OrthoDB" id="1673077at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00495">
        <property type="entry name" value="Ribosomal_L25_TL5_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01334">
        <property type="entry name" value="Ribosomal_L25_CTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029751">
        <property type="entry name" value="Ribosomal_L25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020057">
        <property type="entry name" value="Ribosomal_L25_b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037121">
        <property type="entry name" value="Ribosomal_L25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001021">
        <property type="entry name" value="Ribosomal_L25_long"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01386">
        <property type="entry name" value="Ribosomal_L25p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14693">
        <property type="entry name" value="Ribosomal_TL5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00731">
        <property type="entry name" value="bL25_bact_ctc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000244212" description="50S ribosomal protein L25">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01334"/>
        </source>
    </evidence>
    <sequence length="195" mass="20412" checksum="5087011A1265DCE9" modified="2005-11-22" version="1">MQQKTISIEQREKAGKGVSRKLRAVGRVPGVVYGKGIEPVAVSVDAKELAAAIVGEGGRNNLISLQGGGSLNGNTVIVADLQKAPLKGTFISVDFHKINMDEKVRVHVPVALIGTALGAKEGGMLELVMHSLDLECLPSQIPEHVEVDVTNLAIGHAIHVGELVLAAGVKALDDPKATIVSVHGKTKEEVTVEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RT0</accession>
    <name>Q39RT0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein glutamate methylesterase CheB associated with MCPs of classes 40H and 40+24H, response receiver domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheB64H-2</name>
        <name evidence="3" type="ordered locus">Gmet_2826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513978.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2826"/>
    <dbReference type="EnsemblBacteria" id="ABB33044">
        <property type="protein sequence ID" value="ABB33044"/>
        <property type="gene ID" value="Gmet_2826"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2826"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_2_7"/>
    <dbReference type="OMA" id="MPKRAKE"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheB-type methylesterase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="187" mass="19564" checksum="BE1AB0D689395D6F" modified="2005-11-22" version="1">MPLPNLAVIGASTGGLKVFESLFPHLPVLNAGVVIVQHIVPLVDRSFVTSLQRVSAMPVALARDGDAIRHGTVYLAPGALHLHLVANQTIRLAAGEKVNSVCPSIDVTMESVIPKPGARMAGVILTGMGHDGADGIAHMKRCGAVTIAQDRATSVIYGMPKAAEATGMIDFVLSAERIADKLAELFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S49</accession>
    <name>Q39S49_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein glutamate methyltransferase CheR associated with MCPs of class 40H, TPR domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheR40H-2</name>
        <name evidence="3" type="ordered locus">Gmet_2707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511753.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2707"/>
    <dbReference type="EnsemblBacteria" id="ABB32925">
        <property type="protein sequence ID" value="ABB32925"/>
        <property type="gene ID" value="Gmet_2707"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2707"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_4_1_7"/>
    <dbReference type="OMA" id="PLCVEAR"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="505" mass="56050" checksum="73D2260A2F8F4771" modified="2005-11-22" version="1">MTHHISRQLLSRFSEFVSCQLGLHFPEKRWRDLERRTIHAARDLGFKRVEACVQWLLSSRVSRAEIEILASHLTIGETYFFREKGGFDALESRILPELIDSRRGKEQRLRIWSAGCSSGEEAYSIAILLKKMIPDIDEWNVAILATDINPRALAKAAAGIYSDWSFRGVPEWVKERYFTRCPDGRLEVPFAIRKMVTFANLNLVEDTFPSLVNNTNAMDIIFCRNVLMYFGTEQAGRATGNFHRSLLDGGWLLVSPCEVSSALFADFDAVTFPGALFYRKGGTGKRPAAFSCPLPTEETLHREEPSPFILPVPREHLPPEAGEEKTLPPQPEPSTYEEALALHRQGEYREAAERLCSFLSGSVATDAPHPLFGKAAALLAQLFADLGNLEEALRWSGEAIAADKLNGELHYLRATILQEQGAIGDAVASLKRALYLDHTFVLTHFALGNLTLGQGKKREADRHFANALELLGAYRDDDPVPGGDGMTAGRLADIIGSTRGAGQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SB9</accession>
    <name>Q39SB9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511825.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2636"/>
    <dbReference type="EnsemblBacteria" id="ABB32855">
        <property type="protein sequence ID" value="ABB32855"/>
        <property type="gene ID" value="Gmet_2636"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2636"/>
    <dbReference type="eggNOG" id="COG3238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068878_3_0_7"/>
    <dbReference type="OMA" id="ALQGPWW"/>
    <dbReference type="OrthoDB" id="2005506at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006750">
        <property type="entry name" value="YdcZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34821">
        <property type="entry name" value="PTHR34821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04657">
        <property type="entry name" value="DMT_YdcZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223332" evidence="2">
        <location>
            <begin position="19"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="145" mass="15009" checksum="8334C3C7F945B980" modified="2005-11-22" version="1">MSNLALFLLMMCGGTAVALQPSINARLAQKIGVIESSFVSFTVGALVLAVAVSFWGRGSLRALSTASWWELTGGLLGAAFVTLTIVVVPRIGTAAAMAAIIAAQLTTGLLMDHFALFGFRGAPLDGKRIAGTLLLMAGAALVFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SC4</accession>
    <name>Q39SC4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511830.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2631"/>
    <dbReference type="EnsemblBacteria" id="ABB32850">
        <property type="protein sequence ID" value="ABB32850"/>
        <property type="gene ID" value="Gmet_2631"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2631"/>
    <dbReference type="eggNOG" id="COG0724">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_28_1_7"/>
    <dbReference type="OMA" id="HGLSWHT"/>
    <dbReference type="OrthoDB" id="2029304at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="SSF54928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="134" mass="13939" checksum="A6D9ED77C3168168" modified="2005-11-22" version="1">MSANKELYVGHMSYEATEDDLRRLFTVAGTVTSVHLITDRDTGEFKGCGYVRMATIEEAKEAVETLDGALLRNRAITVTLARPQKQTTRPGGRGGKGGPGPRTGGSRGKGGPAAGSGGPRGKSGPGTRPARGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SJ7</accession>
    <name>Q39SJ7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl-[acyl-carrier-protein] reductase [NADH]</fullName>
            <ecNumber evidence="6">1.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">fabI</name>
        <name evidence="10" type="ordered locus">Gmet_2558</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513476.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2558"/>
    <dbReference type="EnsemblBacteria" id="ABB32777">
        <property type="protein sequence ID" value="ABB32777"/>
        <property type="gene ID" value="Gmet_2558"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2558"/>
    <dbReference type="eggNOG" id="COG0623">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_10_1_7"/>
    <dbReference type="OMA" id="GILDMIH"/>
    <dbReference type="OrthoDB" id="762291at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016631">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05372">
        <property type="entry name" value="ENR_SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014358">
        <property type="entry name" value="Enoyl-ACP_Rdtase_NADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43159">
        <property type="entry name" value="PTHR43159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000094">
        <property type="entry name" value="Enoyl-ACP_rdct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="19"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="64"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000094-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="256" mass="26750" checksum="DFAD8AC6113FB5B4" modified="2005-11-22" version="1">MGLLDGKKAVIFGIANEKSIAWAIAQAFRREGAELAVTYANETVAKRVIPLAESVGASLVLPCDVRNDAEIQSVFEEIGKAWGGIDILVHSIAFAGKEELKGSFLNTTREGFALALDISAYSLIALMKAAHPFMAGREGSVLALTYYGGQKVFPNYNVMGVAKAALEMSVKYLAEAVGSDGIRVNAISAGPLKTLASSGVGGFNQIAGHVAEKAPLRRNISQDEVAGAAVYLASSLASGVSGEIHFVDSGYNIIGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SK1</accession>
    <name>Q39SK1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513480.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2554"/>
    <dbReference type="EnsemblBacteria" id="ABB32773">
        <property type="protein sequence ID" value="ABB32773"/>
        <property type="gene ID" value="Gmet_2554"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2554"/>
    <dbReference type="eggNOG" id="COG1906">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056143_0_0_7"/>
    <dbReference type="OMA" id="PMPGGAY"/>
    <dbReference type="OrthoDB" id="801223at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007294">
        <property type="entry name" value="DUF401"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39556">
        <property type="entry name" value="PTHR39556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04165">
        <property type="entry name" value="DUF401"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="404" mass="43379" checksum="4308925484B3FF43" modified="2005-11-22" version="1">MIDLLKTLAVLVAVVVMVRRRWHLGAVMALGAAFLAFSYLTPPLKFLGGAWVALASPKSLEMTATLVFTMIMEHILRTTGTLRRMVASLSEVLPDSRLIMAAMPAMIGMLPSPGGAVFSAPMVREASAHLTLPADQKAFINYWYRHPWEYISPLYPGIILVAGLSRIPYQKIVLANSAFAVSVIFWGVIFCFRGVGSAPVPVGETVGKRRALSTFIISVAPILATLIFVVVLQVNPVVAMGGMTALLFAVHRYGPARIVTTLRESVSVKALSLIFGIMIFQETLRLTGALDGISHFFVASGLPVLFIITAIPFLAGVMTGLTVAFVGITFPILMPLMGGDIPSLGLLSLAFGSGFAGVMLSPVHLCLVLTGEYFGADMARVFRRLWIPQALVLAAAVVPVYIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ST6</accession>
    <name>Q39ST6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidoglycan L,D-transpeptidase, YkuD family, LysM domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2463</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32688.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512437.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2463"/>
    <dbReference type="EnsemblBacteria" id="ABB32688">
        <property type="protein sequence ID" value="ABB32688"/>
        <property type="gene ID" value="Gmet_2463"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2463"/>
    <dbReference type="eggNOG" id="COG1376">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_591553_0_0_7"/>
    <dbReference type="OrthoDB" id="975147at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="LysM" evidence="5">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32688.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="462" mass="51563" checksum="EFCBC213E0FEDEB9" modified="2012-10-31" version="2">MCRVGVGMGGTVSFLAAAVLFAGCSTPPTAKKRALTELSGLRQRSASSISRQEYWNIEETVARAESHLARGERKRAEVLFDLAAGKAKLLSERLELAQAEKDEPQPSSRDAVSKQTADWDDQLPPPAMDSVSPLPPPAPASPAMAPPTEHLHPQSAPAPVEPAEPQPGEMRSVERGEPAEATETARPRSSVIIGKRFSYTVGKGESLRYIGAKFGVSWRRLAQLNRIDPQKPLRAGQVLRVDTRRIVPRQIDDGIVINIPDRTLYYFRNGEVDRVLSVAVGKPKPVNDPEKRDWHTPTGNFRIIGKVKDPTWRVPPSIRKEMKERGKEVKTIVPPGKKNPLGKYALKTSIPGILIHSTNAPESVYSFSSHGCIRVFPEFMEDFFNSVTEETTGEIIYEPVKMTVAEGQVFLEVHRDIYNRYENLDEQVKSIAQEQHVEERIDWNKVQQVLKRMNGVPERVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SX4</accession>
    <name>Q39SX4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512475.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2425"/>
    <dbReference type="EnsemblBacteria" id="ABB32650">
        <property type="protein sequence ID" value="ABB32650"/>
        <property type="gene ID" value="Gmet_2425"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2425"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_24_7"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="215"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="353" mass="38417" checksum="E89461D0048EFDBC" modified="2005-11-22" version="1">MLQSHIMAGNCTVKPARMTRAPYARHELKSTNSGCDESPAALERRVAELLLVADFGAVVGSILDPRQVCEVASSWLGETLGWQMLSVCCHDFSTGTMRGGAGRGRHLSKKRQEGATSTVFIAAAQKGLSDAADVRTIPFPDGSGTLSLSRQSLAESQYSDEFFGGVVENLARSLAAARECDRLKNLSMRDHLTGLYNRRVFEAMLEVEARKRTTKPFSLLLIDLDDFKRVNDTYGHGAGDQVLVAVAKMLRLSFRKSDVVSRYGGEEFGVLLPDTSQDSARVVAERFRQNVATLSLPVNKEKIMPTVSVGIASVTLRLGIEVADVIEEADRALYQAKVTGKNRVCSSLLGENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T05</accession>
    <name>Q39T05_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CRISPR_Cas6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366046.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2394"/>
    <dbReference type="EnsemblBacteria" id="ABB32619">
        <property type="protein sequence ID" value="ABB32619"/>
        <property type="gene ID" value="Gmet_2394"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2394"/>
    <dbReference type="eggNOG" id="COG5551">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050021_0_0_7"/>
    <dbReference type="OMA" id="RHQKPPL"/>
    <dbReference type="OrthoDB" id="1828479at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019267">
        <property type="entry name" value="CRISPR-assoc_Cas6_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10040">
        <property type="entry name" value="CRISPR_Cas6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRISPR_Cas6" evidence="1">
        <location>
            <begin position="185"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="309" mass="34487" checksum="AD751371C6ACE227" modified="2005-11-22" version="1">MTIAVLRITIRLAEDISDPYLLFRIRDGFQRSFRRVVGCAEEECVLCNRRNECPYRIVFAQALSSDPATVKRHQKPPLPFAFSFPVIPSQQKSDTLFEIRLALLGTATRFVTEFLDSLKLLCSKHDQRDELAAIVERVESLGYRGEPYLIYAADHSAGFAESLTLLTSEGLCDTRWVDVSGDVTLRLLTPLKIMQDGRPSRTFSFPLLMRTLIRRISSLASYYCDDEILVDFRWLASLCETVTVSGSSIQWVEWGGGKQGRKLAGLTGEAVLSSVPEEFIPFLLLGEFLNVGKGAAFGLGRFSIGANCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T25</accession>
    <name>Q39T25_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nicotinamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2374</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513246.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2374"/>
    <dbReference type="EnsemblBacteria" id="ABB32599">
        <property type="protein sequence ID" value="ABB32599"/>
        <property type="gene ID" value="Gmet_2374"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2374"/>
    <dbReference type="eggNOG" id="COG1335">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068979_13_1_7"/>
    <dbReference type="OMA" id="DFVDSWP"/>
    <dbReference type="OrthoDB" id="1442962at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="SSF52499"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="199" mass="21626" checksum="C7A7B34E3D7BFF1F" modified="2005-11-22" version="1">MKSTSALLIVDVQNDFCPGGLLPVPEGDRVVPLLNRYMELFREKKLPIIASRDWHPAITSHFRDFGGIWPVHCVQGSEGARFHRDLALPDDAIVISKGQDPAQDAYSAFQATTESGVSFPELLKELGITRLFVGGLATDYCVKESVLDGLRHGLAVTLLEDAVRGVNLTPGDSARAIENMVVAGAVRMNFSRLQADPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T34</accession>
    <name>Q39T34_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidoglycan-binding lipoprotein, SPOR and NLPC_P60 domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2365</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C40 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513255.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2365"/>
    <dbReference type="MEROPS" id="C40.006"/>
    <dbReference type="EnsemblBacteria" id="ABB32590">
        <property type="protein sequence ID" value="ABB32590"/>
        <property type="gene ID" value="Gmet_2365"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2365"/>
    <dbReference type="eggNOG" id="COG0791">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016043_1_5_7"/>
    <dbReference type="OMA" id="YKVRFGN"/>
    <dbReference type="OrthoDB" id="682655at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000064">
        <property type="entry name" value="NLP_P60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00877">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51935">
        <property type="entry name" value="NLPC_P60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223254" evidence="3">
        <location>
            <begin position="24"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="4">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="NlpC/P60" evidence="5">
        <location>
            <begin position="143"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="266" mass="29257" checksum="AAA9F439444CEDB1" modified="2005-11-22" version="1">MKRFVVHLIAFIVVSLLAAAGCAAPRAGISRIGHAIQVGAFSEVKNAERLAAQLQVRGIEAFYFKRDNGLYAVRFGDFPSKQAAQKEARKLVSDGLIGAYFIAPPQDLSGKRETVVKREPAATIGRLPAEPRKKQPEAPKGEKDMGQIAARTAERFVGIPYRWGGNTVVDGMDCSGFARAVYNLCGVNIPRTSREQFKVGDPVARDDLKDGDLVFFGSSEDSINHVGIYVGDKRFVHAPRRGDDIKISSLDENYFAKKFMGGRRYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T79</accession>
    <name>Q39T79_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PSP1 superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513300.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2320"/>
    <dbReference type="EnsemblBacteria" id="ABB32545">
        <property type="protein sequence ID" value="ABB32545"/>
        <property type="gene ID" value="Gmet_2320"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2320"/>
    <dbReference type="eggNOG" id="COG1774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033149_2_0_7"/>
    <dbReference type="OMA" id="SFEQENY"/>
    <dbReference type="OrthoDB" id="1523756at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007557">
        <property type="entry name" value="PSP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04468">
        <property type="entry name" value="PSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51411">
        <property type="entry name" value="PSP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP1 C-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="348" mass="39539" checksum="FA1E4EE28B9DF7CA" modified="2005-11-22" version="1">MVKIVKAQFHTAGKLYDFGAGDLDLKPGDKIIVETERGRSIATVVTPPREYEEAHVPEGLKTAIRIAEPSDLASAARNDAREQEAHAFCLRKIKERGMEMKLVKVEYLFDGSKAIFYFTADGRVDFRELVKDLAHQFHTRIEMRQIGVRDESKMIGGIGICGRELCCSSFLREFEPVSVKMAKEQNLALNPTKISGQCGRLLCCLGYEYETYCSLKKCLPKCGKVVKCGSTEGEVIKQNIIEGTVFVKTDDDRIVELKGESIKPEDISERPKSPRREGGTREREKEPQSSSDNQRREKPRDREQKPGDDGEQRRERDTKKNQDQQRGERGNRDRRGGKGRDKDKKEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TI4</accession>
    <name>Q39TI4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2213</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365969.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2213"/>
    <dbReference type="EnsemblBacteria" id="ABB32440">
        <property type="protein sequence ID" value="ABB32440"/>
        <property type="gene ID" value="Gmet_2213"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2213"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_7"/>
    <dbReference type="OMA" id="CPIETPA"/>
    <dbReference type="OrthoDB" id="1058688at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="4">
        <location>
            <begin position="5"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="5">
        <location>
            <begin position="270"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="2">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="348"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="392" mass="41174" checksum="3A98398E9CB95563" modified="2005-11-22" version="1">MEEAVIVGAARTAIGDFMGALKDVSAVDLGIAAVQGALKKAGIGPELVEEVVGGMIYKAGAKGNPARQVQLKTGIPLEGAATTVEQLCGSAMRALEIASQQILLGKTSVGVAVGMESMSQAPYLLLNARQGLRLGSDSIEDHLLHDALIDAFSGTHMGITAENLAEKYGISREEQDDLALLSHQRAVAAAESGKFRAEIVPVEVKSRKGTIVIDTDEHPRADMSREKLAALRPAFKKDGTVTAGNASSINDGAAALVLMTARRARELGVSPIARIRATASFGVAPEIMGIGPAYAIPKALKYADLQMKDIDYFEINEAFAAQFLAVNRELNIDLSRVNANGSGIALGHPVGCTGIRIIVTMLEEMKRRQGRYGVASLCVGGGPAMATVIEMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TI6</accession>
    <name>Q39TI6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_2211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365967.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2211"/>
    <dbReference type="EnsemblBacteria" id="ABB32438">
        <property type="protein sequence ID" value="ABB32438"/>
        <property type="gene ID" value="Gmet_2211"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2211"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_12_2_7"/>
    <dbReference type="OMA" id="GNEQQRH"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025878">
        <property type="entry name" value="Acyl-CoA_dh-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12806">
        <property type="entry name" value="Acyl-CoA_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="42"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="162"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="285"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_C" evidence="9">
        <location>
            <begin position="466"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="615" mass="67958" checksum="8651E5D739ADDE41" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TJ0</accession>
    <name>Q39TJ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365963.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2207"/>
    <dbReference type="EnsemblBacteria" id="ABB32434">
        <property type="protein sequence ID" value="ABB32434"/>
        <property type="gene ID" value="Gmet_2207"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2207"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_7"/>
    <dbReference type="OMA" id="MSMTGDY"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="265" mass="28516" checksum="F8836951C66027E8" modified="2005-11-22" version="1">MSFETIILDKKDGIATITFNRPKVFNAYSEQMSQELKAAVADVGSDTSLRVLVLKGSGENFLAGADINMLNSWSKISAEQGWEKVKEILDHHFSPTSLEKIPLPVIAAVDGMAWGMGSEIALGCDFRICTTRASFAQPEINLGIITGGGASQRLPRIVGKAKAMEMILTGKPINAADACKWGLVNEVVEPEGLDAAVARLAKAIMGKSPLMVKWAKDCVNLVLDHDLLSGIDKELTQFAKTFATQDSKEGTAAFLEKRKANFTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TR7</accession>
    <name>Q39TR7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Probable butyrate kinase</fullName>
            <shortName evidence="8">BK</shortName>
            <ecNumber evidence="8">2.7.2.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Branched-chain carboxylic acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">buk</name>
        <name evidence="10" type="synonym">buk-2</name>
        <name evidence="10" type="synonym">pcmL</name>
        <name evidence="10" type="ordered locus">Gmet_2128</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>ATP + butanoate = ADP + butanoyl phosphate</text>
            <dbReference type="Rhea" id="RHEA:13585"/>
            <dbReference type="ChEBI" id="CHEBI:17968"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58079"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8 9">Belongs to the acetokinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.7" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513077.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2128"/>
    <dbReference type="EnsemblBacteria" id="ABB32357">
        <property type="protein sequence ID" value="ABB32357"/>
        <property type="gene ID" value="Gmet_2128"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2128"/>
    <dbReference type="eggNOG" id="COG3426">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048716_0_0_7"/>
    <dbReference type="OMA" id="ANDEGPF"/>
    <dbReference type="OrthoDB" id="537106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047761">
        <property type="term" value="F:butyrate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00542">
        <property type="entry name" value="Butyrate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011245">
        <property type="entry name" value="Butyrate_kin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="PTHR21060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF3">
        <property type="entry name" value="PTHR21060:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036458">
        <property type="entry name" value="Butyrate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02707">
        <property type="entry name" value="butyr_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="362" mass="39080" checksum="7630D1098138C787" modified="2005-11-22" version="1">MDDKKILIINPGSTSTKIGVFTEGKMIVNQSVKHDDEELRKFPTIWDQYDFRRDAIFKVLADNNLSMGEIDAIACRGGNVRPLPGGIYRVCPKMIEDMKSGIYGGHPINVGGLVAFDLGNQFNIPVLTADPPMTDELCASARYSGIPQITRQSSFHALNQKATARKIAAELGKKYDEINLIVAHLGGGISVGAHRRGKIIDVNNALDGDGPFSPERAGSLPAGDLVKLCFSGEYTKKEVLKLLTGKGGLFAYMGTTDAVEIEKRIAHGGQKAAEVYEAMIYQVAKEIGASAAVLEGDVDAIALTGSLAYSKKLVESLSRKISFIAPVLLNPGENEMEALADAAMRYFNNEEALSVYHQDKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TU0</accession>
    <name>Q39TU0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavin prenyltransferase UbiX</fullName>
            <ecNumber evidence="5">2.5.1.129</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">ubiX</name>
        <name evidence="7" type="ordered locus">Gmet_2105</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2</text>
            <dbReference type="Rhea" id="RHEA:37743"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:87467"/>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
            <dbReference type="EC" id="2.5.1.129"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UbiX/PAD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.129" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513099.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2105"/>
    <dbReference type="EnsemblBacteria" id="ABB32334">
        <property type="protein sequence ID" value="ABB32334"/>
        <property type="gene ID" value="Gmet_2105"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2105"/>
    <dbReference type="eggNOG" id="COG0163">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074522_0_1_7"/>
    <dbReference type="OMA" id="GATHIQD"/>
    <dbReference type="OrthoDB" id="1384786at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106141">
        <property type="term" value="F:flavin prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01984">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="PTHR43374"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="SSF52507"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00421">
        <property type="entry name" value="ubiX_pad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0288">FMN</keyword>
    <keyword evidence="1 5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavoprotein" evidence="6">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>dimethylallyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:88052"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="201" mass="22133" checksum="F090DA5E375437D5" modified="2005-11-22" version="1">MSLPLVVAITGATGVIYGVEMLNVLKELGQETHLIVSEAAGKNLEIETSYSLDEVRALADVVYDNKDIGASVASGSFRTRGMIVAPCTVKTLSAIANSFTYNLVIRAADVTLKERRPLVLMVRETPLHKGHLELMSRATDCGAQILPPMPAFYHKPESIMDIVHQSIGKALDQVGIEHNLFKRWHGDNRKEQVRESLRIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TX8</accession>
    <name>Q39TX8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">etfB-2</name>
        <name evidence="4" type="ordered locus">Gmet_2067</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514036.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39TX8"/>
    <dbReference type="STRING" id="269799.Gmet_2067"/>
    <dbReference type="EnsemblBacteria" id="ABB32296">
        <property type="protein sequence ID" value="ABB32296"/>
        <property type="gene ID" value="Gmet_2067"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2067"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_2_1_7"/>
    <dbReference type="OMA" id="REALCMG"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="22"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="270" mass="29317" checksum="511CD1E005B4F80E" modified="2005-11-22" version="1">MLVISCIKQVPDTTQVKIDPVTNTLVREGIPFIVNPYDTHALEEGLNLKDRYGLRSVAISMGPPNTEATLRKACALGVDEAILLSDRAFGGADTLSTSNVLSAAIEKLGAEEAVGIVFCGKQTIDGDTAQVGPGIATRLGYTQLTLVDRIEFLDLKRNVIRVRRKLEGRHEIVEAPLPVVITVVRELNRPRYPTVPMRLAAQETEVKVWDNSVLKLDVETVGLKGSPTWVSKIFSPERDKGEIIGDGVGDPEGTANLLIDKLLSKDLLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U03</accession>
    <name>Q39U03_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PEP motif-containing protein, putative exosortase substrate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512909.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2042"/>
    <dbReference type="EnsemblBacteria" id="ABB32271">
        <property type="protein sequence ID" value="ABB32271"/>
        <property type="gene ID" value="Gmet_2042"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2042"/>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_862664_0_0_7"/>
    <dbReference type="OMA" id="DWNAGSA"/>
    <dbReference type="OrthoDB" id="1798844at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223511" evidence="2">
        <location>
            <begin position="25"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-CTERM" evidence="3">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="322" mass="33677" checksum="40D0B87581D57EC4" modified="2005-11-22" version="1">MKTVKNVAITAALFATCAASNAFAATTTIDFAGVSQPVAQLDWSVGNALGVNAVPLAVTDGTGNPATDPAVNPALQTHFNLYYQAILGNYNNATNKPILGSGLNSTYEITAMIAFGERGYTSAIAGPVPANASFFFDPTLPNYVKFYKSAINASDLAGTGFNDGNEFLSGRVVGVTRSNFSTEANTGLLDQNLGDDWAGQQTIYGTGSTAVTIAVDQINKDEVVITNPLNLDFIIMSLNFNTSNNLPFLQADPSRLFWDVSAGANVVPALGAVNGINGPDIIFQADGNNSFQIAAVPEPSTFALTGLGLLLAGGFMRRRAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U32</accession>
    <name>Q39U32_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polysaccharide deacetylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32242.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2013"/>
    <dbReference type="EnsemblBacteria" id="ABB32242">
        <property type="protein sequence ID" value="ABB32242"/>
        <property type="gene ID" value="Gmet_2013"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2013"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030024_1_1_7"/>
    <dbReference type="OMA" id="FQAHTRF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="1">
        <location>
            <begin position="73"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32242.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="323" mass="36606" checksum="013F327F96CBEC07" modified="2012-10-31" version="2">MVVSWLRKEHPCIILLYHRIVDDQTVYLDKGPVVHHHIRDFEREIAWLKKRFRVLSMDEVVDTIRGGKYFAKPSVAITFDDGYLDNYTLAYPVLKSHGVPAMIYLATGLIGTNARTWPDQIEAALLASTKQTLSLPGLLPDCGAPIKSIEEKRSCCIQLSRVLKGMPDAERKIRLVNIFRELDVTLASLENSNKRTMLNWDEVKEMSANKISFGSHSHTHPILSRVPLHEAQDDIRYSKQVLEVQLGGKVRHFAYPNGRKEDFSEDLRSYCKKIGFDTVATVVFGTVDAGADPFSLKRIGVVSPVWNMAGELTRKFIRRAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U70</accession>
    <name>Q39U70_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphoesterase, PHP family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1975</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511869.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1975"/>
    <dbReference type="DNASU" id="3739197"/>
    <dbReference type="EnsemblBacteria" id="ABB32204">
        <property type="protein sequence ID" value="ABB32204"/>
        <property type="gene ID" value="Gmet_1975"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1975"/>
    <dbReference type="eggNOG" id="COG0613">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067347_1_0_7"/>
    <dbReference type="OMA" id="CTWGGAT"/>
    <dbReference type="OrthoDB" id="1309717at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004013">
        <property type="entry name" value="PHP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003141">
        <property type="entry name" value="Pol/His_phosphatase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02811">
        <property type="entry name" value="PHP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00481">
        <property type="entry name" value="POLIIIAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="SSF89550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLIIIAc" evidence="1">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="293" mass="32304" checksum="55107F90106DC5DC" modified="2005-11-22" version="1">MMSTIDLHVHSNYSDGIHPPADLVKMAAERGLVAIAIADHDTVDGIDEALIAGARLGVEVVPAVELSAEHGRYRDMHILGYHLDHRDPRLVDMLAEFRINREIRGRAIVDKINQRLADGRKPLLSYDEVLNLAEGAVGRPHIGRMLIERGYARNMEDAFRRYLIPCNVPKRYIPAGDAITEIRRAGGVAVLAHPITVSDDRQVLRGIVSELVALGLDGIEVFNNMCYKDDMLFLEFLCRESGLLMTGGSDFHGFEDDVEIGSGRGGLAVSHRLAEAVKNLAESRRITPPGSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UK0</accession>
    <name>Q39UK0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="2">2.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">5'-phosphoribosylglycinamide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="2">GAR transformylase</fullName>
            <shortName evidence="2">GART</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">purN</name>
        <name evidence="4" type="ordered locus">Gmet_1845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>(6S)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide</text>
            <dbReference type="Rhea" id="RHEA:15053"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="EC" id="2.1.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GART family.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512001.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1845"/>
    <dbReference type="EnsemblBacteria" id="ABB32074">
        <property type="protein sequence ID" value="ABB32074"/>
        <property type="gene ID" value="Gmet_1845"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1845"/>
    <dbReference type="eggNOG" id="COG0299">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038395_1_0_7"/>
    <dbReference type="OMA" id="TGITIHY"/>
    <dbReference type="OrthoDB" id="1815747at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00126"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08645">
        <property type="entry name" value="FMT_core_GART"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01930">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004607">
        <property type="entry name" value="GART"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00639">
        <property type="entry name" value="PurN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="3">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="5'-phosphoribosylglycinamide binding" evidence="2">
        <location>
            <begin position="15"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="region of interest" description="10-formyltetrahydrofolate binding" evidence="2">
        <location>
            <begin position="93"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>(6S)-10-formyltetrahydrofolate</name>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
        </ligand>
    </feature>
    <feature type="site" description="Raises pKa of active site His" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="206" mass="22225" checksum="6A1BCB22C2717E34" modified="2005-11-22" version="1">MTDLLTIGVLVSGNGSNLQAIIDRIEDGSLPARIACVISNKADAYALDRAKCHGITVHVLDHRIHAGRESYDAALVELLRSHGVRLVVLAGFMRIVTPVLIGAFPHAIMNIHPALLPAFPGLHAQRQALQYGVKVSGCTVHFVDEGTDTGPIIIQAVVPVLDDDTEDTLSARIQKEEHHIYPEAVNLFAQGRLTVDDRKVIIAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UP2</accession>
    <name>Q39UP2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster-binding oxidoreductase, putative benzoyl-CoA reductase electron transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bamC-2</name>
        <name evidence="2" type="ordered locus">Gmet_1803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512043.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1803"/>
    <dbReference type="EnsemblBacteria" id="ABB32032">
        <property type="protein sequence ID" value="ABB32032"/>
        <property type="gene ID" value="Gmet_1803"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1803"/>
    <dbReference type="eggNOG" id="COG1142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1486797_0_0_7"/>
    <dbReference type="OMA" id="VKWCLVD"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="178" mass="20295" checksum="CBF2B64EF360BA33" modified="2005-11-22" version="1">MAKIKRKVRTITVDADKCNGCRTCEIMCSAFHAVPPYSSNNPARSRIQVITNRLEDIWMPVFAGEYTESECMGRNKYIIDGKEYNECDSCRAACPSRDLFKEPDSGLPLKCDMCDGEDEPVCVKWCLVDALVYEEREEEVEEKDIQTTVTEMEVGLESLVRKHGFDKVMDTVARMSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UX4</accession>
    <name>Q39UX4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thiolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513384.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1719"/>
    <dbReference type="EnsemblBacteria" id="ABB31950">
        <property type="protein sequence ID" value="ABB31950"/>
        <property type="gene ID" value="Gmet_1719"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1719"/>
    <dbReference type="eggNOG" id="COG0183">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031026_0_0_7"/>
    <dbReference type="OMA" id="YEAGRSM"/>
    <dbReference type="OrthoDB" id="1058688at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase_N" evidence="6">
        <location>
            <begin position="4"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase_C" evidence="7">
        <location>
            <begin position="269"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="3">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="391" mass="40723" checksum="75258E9A69946309" modified="2005-11-22" version="1">MQDVFVVDALRTPFGSFSGMLADVEAPKLAATVMKELLAKAGLAPDTVNEVIVGQVLSGGCGQAPARQAMRGAGIPDSAHALTINKVCGSGLKAIMLGADSIRLGESQIVIAGGMENMSLAPFFLKKARAGYRMGHSELLDLLIYDGLQDPYTGRHMGEIGEVSAERGGLTRKEQDAFARRSYELAQAAVTGGIFADEIVPVVKKGKKGDETIGTDEEPFKGDPSKLPSLRAAFKKDGTITAGNASTINDGAALALLTDADGLKKHNLTPKARIVASATESRHPDNFPEAPIGAIEKACAKAGLTVSDIDLFEINEAFASVALLAIKGLGLPLDKVNVNGGACAIGHPIGASGGRLAATVIRELHRRQKRYGLATLCIGGGEAVAVIFERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V10</accession>
    <name>Q39V10_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transposase of ISGme2, IS4 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1315</name>
        <name evidence="4" type="ordered locus">Gmet_1683</name>
        <name evidence="5" type="ordered locus">Gmet_2386</name>
        <name evidence="6" type="ordered locus">Gmet_2507</name>
        <name evidence="7" type="ordered locus">Gmet_3039</name>
        <name evidence="8" type="ordered locus">Gmet_3141</name>
        <name evidence="9" type="ordered locus">Gmet_3183</name>
        <name evidence="10" type="ordered locus">Gmet_3447</name>
    </gene>
    <organism evidence="4 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="4">GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="4">GS-15</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514806.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1315"/>
    <dbReference type="EnsemblBacteria" id="ABB31551">
        <property type="protein sequence ID" value="ABB31551"/>
        <property type="gene ID" value="Gmet_1315"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31914">
        <property type="protein sequence ID" value="ABB31914"/>
        <property type="gene ID" value="Gmet_1683"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32611">
        <property type="protein sequence ID" value="ABB32611"/>
        <property type="gene ID" value="Gmet_2386"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32729">
        <property type="protein sequence ID" value="ABB32729"/>
        <property type="gene ID" value="Gmet_2507"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33254">
        <property type="protein sequence ID" value="ABB33254"/>
        <property type="gene ID" value="Gmet_3039"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33354">
        <property type="protein sequence ID" value="ABB33354"/>
        <property type="gene ID" value="Gmet_3141"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33396">
        <property type="protein sequence ID" value="ABB33396"/>
        <property type="gene ID" value="Gmet_3183"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33656">
        <property type="protein sequence ID" value="ABB33656"/>
        <property type="gene ID" value="Gmet_3447"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1315"/>
    <dbReference type="KEGG" id="gme:Gmet_1683"/>
    <dbReference type="KEGG" id="gme:Gmet_2386"/>
    <dbReference type="KEGG" id="gme:Gmet_2507"/>
    <dbReference type="KEGG" id="gme:Gmet_3039"/>
    <dbReference type="KEGG" id="gme:Gmet_3141"/>
    <dbReference type="KEGG" id="gme:Gmet_3183"/>
    <dbReference type="KEGG" id="gme:Gmet_3447"/>
    <dbReference type="eggNOG" id="COG3385">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043140_0_0_7"/>
    <dbReference type="OMA" id="WITLIAN"/>
    <dbReference type="OrthoDB" id="1254910at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025399">
        <property type="entry name" value="DUF4372"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002559">
        <property type="entry name" value="Transposase_11"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01609">
        <property type="entry name" value="DDE_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14294">
        <property type="entry name" value="DUF4372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4372" evidence="2">
        <location>
            <begin position="4"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_1" evidence="1">
        <location>
            <begin position="124"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="389" mass="45334" checksum="1EB713954C52AEB3" modified="2005-11-22" version="1">MHTGPTVFKQLLQFLPRYEFNLCVRRHRGEYREKKFSTYDQFLCLAYAQMAGRESLRDIETCLNSHQEKLYHIGFRGDVSRTTLADANERRDWRIFQDFGHVLIGIAQQLYQADAIAVELTQPLYAFDSTTIDLCLTLFPWAEFRKTKAAVKMHTLIDLRGPIPTWVTITTGKVHDVRMLDHLPVAKDAIYTMDRGYVDFARLHSIHKQGAFFVVRAKDNLKCQRLYSHPKDKESGVRADQIITLVTQKSKKGYPEKLRRVSYVDKERNKRLVFLTNNFEIPAATVAAIYKQRWQVELFFKWIKQHLRIKSFIGTSVNAVKSQIWVALCIYLLVAITKKKLGVPCSLYTFLQILEVNLFEKKPISSLVAEALKRNADYPERNQLNLFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V21</accession>
    <name>Q39V21_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511391.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1672"/>
    <dbReference type="EnsemblBacteria" id="ABB31903">
        <property type="protein sequence ID" value="ABB31903"/>
        <property type="gene ID" value="Gmet_1672"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1672"/>
    <dbReference type="eggNOG" id="COG2050">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089876_6_2_7"/>
    <dbReference type="OMA" id="ICAQACM"/>
    <dbReference type="OrthoDB" id="1814691at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="1">
        <location>
            <begin position="47"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="132" mass="14494" checksum="F622A2390177DED5" modified="2005-11-22" version="1">MQVIDDNHCFICGSNNPIGLHAVFTTDPEKGRAETRVSIPEHFQGWQGIVHGGILSALMDEICVQACMARGLQVVTSEMRLRYRKPVPTGSEVTVIGEIVGDRRRLIDVRGVIELDGQTMAEAEVIMFKTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V96</accession>
    <name>Q39V96_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511469.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1596"/>
    <dbReference type="DNASU" id="3741612"/>
    <dbReference type="EnsemblBacteria" id="ABB31828">
        <property type="protein sequence ID" value="ABB31828"/>
        <property type="gene ID" value="Gmet_1596"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1596"/>
    <dbReference type="eggNOG" id="COG1399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_100236_1_1_7"/>
    <dbReference type="OMA" id="RLDHRNP"/>
    <dbReference type="OrthoDB" id="1665714at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003772">
        <property type="entry name" value="YceD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02620">
        <property type="entry name" value="YceD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="179" mass="19814" checksum="67F2045934FDA831" modified="2005-11-22" version="1">MKIRVDDITDQPKILSFQEPSEAFPSLAELQATGESEFLSPLMVELAVSKEYGHIRVKGSVAVKIRFVCSRCLVPFDADISSAFTMFYSEGSRIDSDEDEIELAEEDLVSVFYEGDEIDFAPEIAEQVIMELPLKPLCGEGCKGLCVTCGADLNEGECGCERTTFNVKFSALKNFKVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VB9</accession>
    <name>Q39VB9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">Corrinoid adenosyltransferase</fullName>
            <ecNumber evidence="5 8">2.5.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cob(II)alamin adenosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Cob(II)yrinic acid a,c-diamide adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cobA</name>
        <name evidence="9" type="ordered locus">Gmet_1573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>2 ATP + 2 cob(II)alamin + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)alamin + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:28671"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16304"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>2 ATP + 2 cob(II)yrinate a,c diamide + reduced [electron-transfer flavoprotein] = 2 adenosylcob(III)yrinate a,c-diamide + 3 H(+) + oxidized [electron-transfer flavoprotein] + 2 triphosphate</text>
            <dbReference type="Rhea" id="RHEA:11528"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18036"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="ChEBI" id="CHEBI:58503"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="EC" id="2.5.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 2/7.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 8">Belongs to the Cob(I)alamin adenosyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.17" evidence="5 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511492.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1573"/>
    <dbReference type="EnsemblBacteria" id="ABB31805">
        <property type="protein sequence ID" value="ABB31805"/>
        <property type="gene ID" value="Gmet_1573"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1573"/>
    <dbReference type="eggNOG" id="COG2109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088595_2_0_7"/>
    <dbReference type="OMA" id="HAMGEGF"/>
    <dbReference type="OrthoDB" id="1690483at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00233"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008817">
        <property type="term" value="F:cob(I)yrinic acid a,c-diamide adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00561">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003724">
        <property type="entry name" value="CblAdoTrfase_CobA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02572">
        <property type="entry name" value="CobA_CobO_BtuR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015617">
        <property type="entry name" value="Adensltrnsf_CobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00708">
        <property type="entry name" value="cobA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR015617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="176" mass="19265" checksum="0F1A0AB20103749D" modified="2005-11-22" version="1">MKLEQGCIQIYTGNGKGKTTAALGLAFRALGRGMKVFMLQFMKGGGPYGEHAAAERFAPDFTIIQTGRPGWVDRDNPDPEDARLAREALETARTALTSGEYDLVILDEVNGAVSFGLLPVEDLLILMEQRPLCVELVLTGRNADERVIAAADLVTEMREIKHYYRAGVPARVGIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VE6</accession>
    <name>Q39VE6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1544</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511522.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1544"/>
    <dbReference type="EnsemblBacteria" id="ABB31778">
        <property type="protein sequence ID" value="ABB31778"/>
        <property type="gene ID" value="Gmet_1544"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1544"/>
    <dbReference type="eggNOG" id="ENOG50348U9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1785051_0_0_7"/>
    <dbReference type="OMA" id="CNECHAT"/>
    <dbReference type="OrthoDB" id="2041761at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010980">
        <property type="entry name" value="Cyt_c/b562"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002321">
        <property type="entry name" value="Cyt_c_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01322">
        <property type="entry name" value="Cytochrom_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47175">
        <property type="entry name" value="SSF47175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51009">
        <property type="entry name" value="CYTCII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223536" evidence="1">
        <location>
            <begin position="23"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="141" mass="15254" checksum="C8EA7C60C5C942F5" modified="2005-11-22" version="1">MMKKATMLAACILLLTQGGALAHGGEMHGKKHRDTRMDKLHRIMPMYAEAQTKINGALEKGDATTVEAEAGEMAGTIPDLKKAKPHKNLKKIDTFKKIADDFGSKVTATVALAKKGDIAGAKTAFKKAEEKCNECHATFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VL6</accession>
    <name>Q39VL6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511594.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31708">
        <property type="protein sequence ID" value="ABB31708"/>
        <property type="gene ID" value="Gmet_1474"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1474"/>
    <dbReference type="eggNOG" id="ENOG5033XKQ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1136777_0_0_7"/>
    <dbReference type="OMA" id="DYTTMEC"/>
    <dbReference type="OrthoDB" id="1722025at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="253" mass="28958" checksum="3BA27139F5C4C7F8" modified="2005-11-22" version="1">MNDVDRVTVSTPKHARIFLFIAASLLSTLSLMISGAIDCSASPDARESRYEIFSRGLRVGSLTTSFSHARYNDRRALRFESNTRVKANLLVYSVSYESHETALVTEEGTVTYTRSDRRKGQQLEATGRLERDRFILDVTENGNRRTLLFDKSRYDHTTMECPETLMGRVGEEMSLRLLDFESLSIVTRRYRWVKTEDVIVEGKPVRCRVIDFEDSHKKGRRWIKADDLGVIIARQDGKGKDGSYSLRMTKLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VM2</accession>
    <name>Q39VM2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrolase or acyltransferase, alpha/beta fold family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31702.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511601.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1468"/>
    <dbReference type="ESTHER" id="geomg-q39vm2">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31702">
        <property type="protein sequence ID" value="ABB31702"/>
        <property type="gene ID" value="Gmet_1468"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1468"/>
    <dbReference type="eggNOG" id="COG0596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020336_9_0_7"/>
    <dbReference type="OMA" id="WIQPEVA"/>
    <dbReference type="OrthoDB" id="1119700at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="88"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31702.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="346" mass="37651" checksum="E1FB3A51AB598B99" modified="2012-10-31" version="2">MARPSAPPMRVHGDELLYAARKILNIAPGIRGYGRMVSALLPCLTGVGCLYQAVATALDRRRYPPPGRLLKIGGTDVHFHATDRRGAPTVVLETGLGGMSSAWGWIQPEVAKFARVVSYDRAGLGWSAPDDLPRTALTVTRRLRALLHDGEVEGPYVLVGHSMGGMFMRFFADQYPGDVAGMVLIDAAHPDQHRRSPAIRRHMSSGFRMLRGVPLLAGLGYVRMTGFFSSWAVGLPERHAAEAEAFLSSYTHLKTTRDESLAWDAVCAEVRSTGRLGDRPLAVVSAGKDVLPGSHELQSELAALSSRSIHLTVEGADHVTLVTHRQHAMAVVDAIRQVVQMADRER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VP2</accession>
    <name>Q39VP2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Exopolysaccharide synthesis membrane protein H (Exosortase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_1448</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511621.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1448"/>
    <dbReference type="EnsemblBacteria" id="ABB31682">
        <property type="protein sequence ID" value="ABB31682"/>
        <property type="gene ID" value="Gmet_1448"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1448"/>
    <dbReference type="eggNOG" id="COG4083">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_836158_0_0_7"/>
    <dbReference type="OMA" id="VRVITEC"/>
    <dbReference type="OrthoDB" id="1902646at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026392">
        <property type="entry name" value="Exo/Archaeosortase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026441">
        <property type="entry name" value="Exosort_XrtH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019127">
        <property type="entry name" value="Exosortase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09721">
        <property type="entry name" value="Exosortase_EpsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04178">
        <property type="entry name" value="exo_archaeo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04177">
        <property type="entry name" value="exosort_XrtH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="327" mass="35188" checksum="0343EC6785B7D7BC" modified="2005-11-22" version="1">MELAAGHDGGTIRAIRFAVVALVLFLAEFLAPEAVFEPLNRTTAIMTAELLGLMGRHAQAAGTLVRLDGFSARVVTECSVINPAILFASFVLGSGASPRAKAAGILAGIPILNSINVLRIAAVIATGAAVPALFEAVHVYVGQILMVGVVLFGAILWSRWASADGVATFPFVPGVLAWSVVLFVPWLFMNRWYVAVGDIPLRFLFEMAGRPVELPVERPLYYQTFNSVLFASLVLATGSIPIRRKAVFLAGGLALLAVGHQLFRVCNILLSAFGIREAYLASVAIHEILGYLLPFLLWFILCHGVSRPSAHRQGSAEKDRREADTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VT9</accession>
    <name>Q39VT9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1401</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365821.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1401"/>
    <dbReference type="EnsemblBacteria" id="ABB31635">
        <property type="protein sequence ID" value="ABB31635"/>
        <property type="gene ID" value="Gmet_1401"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1401"/>
    <dbReference type="eggNOG" id="COG1277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070325_0_1_7"/>
    <dbReference type="OMA" id="NGFREAR"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="271" mass="29471" checksum="FA8D1A0309CF283F" modified="2005-11-22" version="1">MLVPSHFFVSFLGVAWVGFFRDKILYALFGVALFLLLLAPTLSFFSMRQVQELSITLSLSAISISLLLLAVFLGATSIWRDIERRYTSSVLGLPVARSTYVLGKFAGIAMFLLVGTLVLGAVALLVIPIASLQYPSSVPIPWFNIVAAILADGFKAVLIAAVALLFSSLSTSFFLPIFGTLSVCLAGSASQEVIEFVRGDYGKQLAPVSRLAIEAIYYLLPNLSAFDLKVQAIYGLPIDLSSLLLTFAYFLVYVAVVLFLAVCSFNRRELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VV9</accession>
    <name>Q39VV9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Disulfide bond formation oxidoreductase DsbB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">dsbB</name>
        <name evidence="6" type="ordered locus">Gmet_1381</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31615.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513127.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1381"/>
    <dbReference type="EnsemblBacteria" id="ABB31615">
        <property type="protein sequence ID" value="ABB31615"/>
        <property type="gene ID" value="Gmet_1381"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1381"/>
    <dbReference type="eggNOG" id="COG1495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090583_1_0_7"/>
    <dbReference type="OMA" id="CGYDNPI"/>
    <dbReference type="OrthoDB" id="1859420at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003752">
        <property type="entry name" value="DiS_bond_form_DsbB/BdbC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023380">
        <property type="entry name" value="DsbB-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02600">
        <property type="entry name" value="DsbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158442">
        <property type="entry name" value="SSF158442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31615.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="236" mass="26677" checksum="991778DC51AF7227" modified="2012-10-31" version="2">MKLSEMFGNFRSDPAGTISQWQDKRFLWIFMAVLSLFMVILAHSVFQIWLYMRPCEQCVYIRLAFFAMAFGGVVAAIKPSNPGLKIVGYLFAIWGSFKGVLYSIKLNKIHHAAHSDDIFGVQGCSPEPTFPFHLPLDKWSPEWFKPTGDCGYDNPIIPDGVQLSAMQKAITDFYSEGWYLWPPSHFMNMAQCTLITFGVILLFLVVAAACWIVTLVRRKRQSATHEETSSCSGKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VX3</accession>
    <name>Q39VX3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513141.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1367"/>
    <dbReference type="EnsemblBacteria" id="ABB31601">
        <property type="protein sequence ID" value="ABB31601"/>
        <property type="gene ID" value="Gmet_1367"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1367"/>
    <dbReference type="eggNOG" id="ENOG5033UHW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1141294_0_0_7"/>
    <dbReference type="OMA" id="VGGTFIY"/>
    <dbReference type="OrthoDB" id="1161666at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="245" mass="27703" checksum="AB0F24A5D592F8DD" modified="2005-11-22" version="1">MADITTVDLVQITFWFLAGCISFYFSIGNARVWTSISLGFFLIFLSQLYVVEKALDMPWTAYTQLEAIHYIIGTISIMVMTHGFQEYYIFSRTLEIGGTKTAVYLTVLGVVAASVVFVFINPEPQYTVLRNISVIENATWVFLSLVNLDMVRKIYAQIRDSVIAKGFIGFGIVFIAIFLWKGAELYLQVYNWDADWKLIMQNLGGVVPDLYSGRRDFSLLVHDYAGLLSGVSVGGTFIYLLKLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W18</accession>
    <name>Q39W18_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin, HicB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1321</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365806.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1321"/>
    <dbReference type="EnsemblBacteria" id="ABB31556">
        <property type="protein sequence ID" value="ABB31556"/>
        <property type="gene ID" value="Gmet_1321"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1321"/>
    <dbReference type="eggNOG" id="COG1598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_181344_0_0_7"/>
    <dbReference type="OrthoDB" id="1978030at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035069">
        <property type="entry name" value="TTHA1013/TTHA0281-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143100">
        <property type="entry name" value="SSF143100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="76" mass="8674" checksum="43AA323633AD5ED4" modified="2005-11-22" version="1">MERMIQIHIEKLPEGVYLATSDDIQGLVVQGRTVSETLEIARDVARRLIEAQTERKKTIKLKPIRKSFDLDLVVGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W41</accession>
    <name>Q39W41_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vitamin B12-dependent ribonucleotide reductase</fullName>
            <ecNumber evidence="11">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">nrdJ</name>
        <name evidence="15" type="ordered locus">Gmet_1297</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>adenosylcob(III)alamin</name>
            <dbReference type="ChEBI" id="CHEBI:18408"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Genetic information processing; DNA replication.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the ribonucleoside diphosphate reductase class-2 family.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="11"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512069.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1297"/>
    <dbReference type="EnsemblBacteria" id="ABB31533">
        <property type="protein sequence ID" value="ABB31533"/>
        <property type="gene ID" value="Gmet_1297"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1297"/>
    <dbReference type="eggNOG" id="COG0209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000404_2_0_7"/>
    <dbReference type="OMA" id="LEIWHID"/>
    <dbReference type="OrthoDB" id="357568at2"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031419">
        <property type="term" value="F:cobalamin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02888">
        <property type="entry name" value="RNR_II_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013344">
        <property type="entry name" value="RNR_NrdJ/NrdZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024434">
        <property type="entry name" value="TSCPD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12637">
        <property type="entry name" value="TSCPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="SSF48168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02504">
        <property type="entry name" value="NrdJ_Z"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0846">Cobalamin</keyword>
    <keyword evidence="10 11" id="KW-0170">Cobalt</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 11" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonuc_red_lgN" evidence="12">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RIBORED_LARGE" evidence="13">
        <location>
            <begin position="96"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="TSCPD" evidence="14">
        <location>
            <begin position="605"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB31533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="742" mass="81521" checksum="682D87511F901B1C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W45</accession>
    <name>Q39W45_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oxidoreductase, 2-nitropropane dioxygenase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1293"/>
    <dbReference type="EnsemblBacteria" id="ABB31529">
        <property type="protein sequence ID" value="ABB31529"/>
        <property type="gene ID" value="Gmet_1293"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1293"/>
    <dbReference type="eggNOG" id="COG2070">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038732_0_1_7"/>
    <dbReference type="OMA" id="ATYECDA"/>
    <dbReference type="OrthoDB" id="275153at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NMO" evidence="1">
        <location>
            <begin position="4"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="361" mass="38532" checksum="7A2ECCB8A5E35FEE" modified="2005-11-22" version="1">MGPLKIGKHEARYPLIQGGMGVRISGWRLAGHVARCGGVGLVATAGITLNSGLYTGSNYLQSNPEALRQELRKAYEVAPDGVIGVNIMVALADYEELVQASIEGGAKVIVCGAGLPMTLPGLTAHAPDVAIVPIVSSLRAAQLIAKKWDKGYGRLPDAVVVEDPDTAGGHLGEKLENIGTGDYDQYGTIRSIKEFFRSEYGKEIPIIAAGGIWDRADVLHAIAEGADGVQMASRFVPTVECDAEDAYKQMYLDCRKEDIGLIMSPAGLPGRAILSNQENITLYDETNATSCSNACLKKCSYKESGERFCIVSALDRAQQGDVESGLVFCGTNAWKADRITTVQEIFDELFAEEAGQAEKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WF3</accession>
    <name>Q39WF3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase of ISGme7, IS3 family, OrfA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1184"/>
    <dbReference type="DNASU" id="3738455"/>
    <dbReference type="EnsemblBacteria" id="ABB31421">
        <property type="protein sequence ID" value="ABB31421"/>
        <property type="gene ID" value="Gmet_1184"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1184"/>
    <dbReference type="eggNOG" id="COG2963">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_34_1_7"/>
    <dbReference type="OMA" id="AEATFYV"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004803">
        <property type="term" value="F:transposase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002514">
        <property type="entry name" value="Transposase_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01527">
        <property type="entry name" value="HTH_Tnp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0814">Transposable element</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="85" mass="9791" checksum="2948F7E004D9EE9D" modified="2005-11-22" version="1">MKKSRFTEEQVAAAIRQAESGVPVAEICRRLGVTEVTFYRWKKQFAGMGVTELRKLRQLEDENRKLKSLVADLTLDKHMLQEVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WI0</accession>
    <name>Q39WI0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protease HtpX homolog</fullName>
            <ecNumber evidence="12">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12 14" type="primary">htpX</name>
        <name evidence="14" type="ordered locus">Gmet_1156</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase M48B family.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513421.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1156"/>
    <dbReference type="DNASU" id="3740383"/>
    <dbReference type="EnsemblBacteria" id="ABB31394">
        <property type="protein sequence ID" value="ABB31394"/>
        <property type="gene ID" value="Gmet_1156"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1156"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042266_3_0_7"/>
    <dbReference type="OMA" id="AVCCTEG"/>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00188">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022919">
        <property type="entry name" value="Pept_M48_protease_HtpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 12 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 12" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="13">
        <location>
            <begin position="67"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB31394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="287" mass="30827" checksum="FE31DBD3053F0BE8" modified="2005-11-22" version="1">MMNRLKTTLLLTLLTLLMVAMGSAIGGKSGMVFAFFMACAMNFFSYWFSDKIVLKMYGAREITEAENPAFYGMVRRLATSGGLPMPRVYVIPSDSPNAFATGRNPNHAAVAATEGILRILSLEELEGVMAHELSHVKNRDILVSTIAATFAGAISMLGNMLQWAAIFGGGRSDDDEGAGGMIGGLAMAIIAPIAAMLIQMAVSRSREYLADESGARICGNPLALANALKKLQMASQMVPMQQATPASAHLFIVNPLTGGALLNLFSTHPPMEERIARLEQMAYNRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WL7</accession>
    <name>Q39WL7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Transposase of ISGme4, IS21 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0321</name>
        <name evidence="9" type="ordered locus">Gmet_1118</name>
        <name evidence="10" type="ordered locus">Gmet_1789</name>
        <name evidence="11" type="ordered locus">Gmet_2272</name>
        <name evidence="12" type="ordered locus">Gmet_2539</name>
        <name evidence="13" type="ordered locus">Gmet_2586</name>
        <name evidence="14" type="ordered locus">Gmet_2797</name>
        <name evidence="15" type="ordered locus">Gmet_3282</name>
    </gene>
    <organism evidence="9 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="9">GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="9">GS-15</strain>
        </source>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transposase IS21/IS408/IS1162 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514801.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0321"/>
    <dbReference type="DNASU" id="3741575"/>
    <dbReference type="EnsemblBacteria" id="ABB30564">
        <property type="protein sequence ID" value="ABB30564"/>
        <property type="gene ID" value="Gmet_0321"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31357">
        <property type="protein sequence ID" value="ABB31357"/>
        <property type="gene ID" value="Gmet_1118"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32020">
        <property type="protein sequence ID" value="ABB32020"/>
        <property type="gene ID" value="Gmet_1789"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32498">
        <property type="protein sequence ID" value="ABB32498"/>
        <property type="gene ID" value="Gmet_2272"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32758">
        <property type="protein sequence ID" value="ABB32758"/>
        <property type="gene ID" value="Gmet_2539"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32805">
        <property type="protein sequence ID" value="ABB32805"/>
        <property type="gene ID" value="Gmet_2586"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33015">
        <property type="protein sequence ID" value="ABB33015"/>
        <property type="gene ID" value="Gmet_2797"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33495">
        <property type="protein sequence ID" value="ABB33495"/>
        <property type="gene ID" value="Gmet_3282"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0321"/>
    <dbReference type="KEGG" id="gme:Gmet_1118"/>
    <dbReference type="KEGG" id="gme:Gmet_1789"/>
    <dbReference type="KEGG" id="gme:Gmet_2272"/>
    <dbReference type="KEGG" id="gme:Gmet_2539"/>
    <dbReference type="KEGG" id="gme:Gmet_2586"/>
    <dbReference type="KEGG" id="gme:Gmet_2797"/>
    <dbReference type="KEGG" id="gme:Gmet_3282"/>
    <dbReference type="eggNOG" id="COG4584">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020626_4_0_7"/>
    <dbReference type="OMA" id="HIHAFAF"/>
    <dbReference type="OrthoDB" id="362657at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032196">
        <property type="term" value="P:transposition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017894">
        <property type="entry name" value="HTH_IS21_transposase_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00665">
        <property type="entry name" value="rve"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50531">
        <property type="entry name" value="HTH_IS21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0814">Transposable element</keyword>
    <keyword evidence="3" id="KW-0815">Transposition</keyword>
    <feature type="domain" description="HTH IS21-type" evidence="6">
        <location>
            <begin position="5"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Integrase catalytic" evidence="7">
        <location>
            <begin position="115"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB33015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB33495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="341" mass="39404" checksum="D0F60DED0AA91534" modified="2005-11-22" version="1">MIGKEECMEVRILKKQGKSIREISRITGLCRNTVRKFLRSTADPRYKERAKRPGKLDPFKAFLEERVKAALPHRIPAPVLAREIASFGYDGCERTVRTFLATLYSRVTPEPVVRFETEPGKQMQADWCELRRGKHPLYAFVGTLGFSRDSFVVFTTSQAFDVLRECHEMAFSFFGGVPREVLYDNMKTVVLERNAFGEGKHRFHSGLWDTAKHFGFIPRLCKPYRAKTKGKVERFNRYLRYSFYYPLVSRLKQAGLTLDVATANIEVRNWLNDVANCRIHGETSERPCDRLKIERAAMSPLPPRVKVEQGKPEVITPMPWPVIPLQRPASFYDQILQEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WP8</accession>
    <name>Q39WP8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase-like cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513742.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1086"/>
    <dbReference type="EnsemblBacteria" id="ABB31326">
        <property type="protein sequence ID" value="ABB31326"/>
        <property type="gene ID" value="Gmet_1086"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1086"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057059_0_0_7"/>
    <dbReference type="OMA" id="IVNNMER"/>
    <dbReference type="OrthoDB" id="670657at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223568" evidence="1">
        <location>
            <begin position="23"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="188"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="338" mass="37403" checksum="6540BD3D5C7E3CF3" modified="2005-11-22" version="1">MLKRYVMSVAILMSVAVSTAFGAASRAGVVTVDVDLSAQEKGKEVKLWLPYPVSDANQSITGISVTGDYAESGVYTDRANGTPILYTRWKDDATSRKLSFTFAAERQEVVRRAFPKKETAWDPADYRQYLAPTSLGPTSGEVKKLADSITKGKQTVLEKARAIYDWTCENTYRDPNTKGCGKGDVCALLQKPGGKCTDISSVFVALSRAAGVPAREIFGIRLGKKAQEDITGWQHCWVEFYLPGYGWVPVDPADVRKAILVENLKLDDATTKECREYFWGGIDPYRIALAVGRDLVLNPPQDGPPLNTFGYPYAEVGGKAVDFYDPQGFRYSIRYREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WR8</accession>
    <name>Q39WR8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">CRISPR-associated protein Csd1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">csd1</name>
        <name evidence="1" type="ordered locus">Gmet_1066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513242.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1066"/>
    <dbReference type="EnsemblBacteria" id="ABB31306">
        <property type="protein sequence ID" value="ABB31306"/>
        <property type="gene ID" value="Gmet_1066"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1066"/>
    <dbReference type="eggNOG" id="ENOG502Z7WH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031037_0_0_7"/>
    <dbReference type="OMA" id="TIRDRFY"/>
    <dbReference type="OrthoDB" id="924061at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010144">
        <property type="entry name" value="CRISPR-assoc_prot_Csd1-typ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09709">
        <property type="entry name" value="Cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01863">
        <property type="entry name" value="cas_Csd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="586" mass="65343" checksum="D57237134DFC338C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WV3</accession>
    <name>Q39WV3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513204.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1031"/>
    <dbReference type="EnsemblBacteria" id="ABB31271">
        <property type="protein sequence ID" value="ABB31271"/>
        <property type="gene ID" value="Gmet_1031"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1031"/>
    <dbReference type="eggNOG" id="ENOG5032WID">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097110_0_0_7"/>
    <dbReference type="OMA" id="TFNMEGT"/>
    <dbReference type="OrthoDB" id="1046637at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011467">
        <property type="entry name" value="DUF1573"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07610">
        <property type="entry name" value="DUF1573"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223571" evidence="1">
        <location>
            <begin position="26"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="231" mass="24675" checksum="5B4DB4C5DB5187BE" modified="2005-11-22" version="1">MIRHPLHTLAVVAFLILTLSLPAFAAPVLEVDRPVFDFGSISQGKKLEHVFKLMNKGDSPLTINRTKTSCGCTVANVSTKTIAPGKSADLKISFDSANFGGKVTKTITVESNDPASPTTTLTIKGNINEELVVTPHQINLGQTKAGSSKEASVALENHGERTVKILSVTTPMPQVKATIKKHALKPGERTQLSVTVSPRPEDRFLSGFIIIATDIPGKPEITLPLYGSVAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WX5</accession>
    <name>Q39WX5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger transcriptional regulator, TraR/DksA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365760.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1007"/>
    <dbReference type="EnsemblBacteria" id="ABB31249">
        <property type="protein sequence ID" value="ABB31249"/>
        <property type="gene ID" value="Gmet_1007"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1007"/>
    <dbReference type="eggNOG" id="COG1734">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043144_4_0_7"/>
    <dbReference type="OMA" id="MEDAMGR"/>
    <dbReference type="OrthoDB" id="1932026at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037187">
        <property type="entry name" value="DnaK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000962">
        <property type="entry name" value="Znf_DskA_TraR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020458">
        <property type="entry name" value="Znf_DskA_TraR_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01258">
        <property type="entry name" value="zf-dskA_traR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109635">
        <property type="entry name" value="SSF109635"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01102">
        <property type="entry name" value="ZF_DKSA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51128">
        <property type="entry name" value="ZF_DKSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DksA C4-type" evidence="5">
        <location>
            <begin position="48"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="dksA C4-type" evidence="4">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="14750" checksum="E6426DB923D26788" modified="2005-11-22" version="1">MTRMSRERQERLMELLLAEKRRLWGEVRRELFGQVGGELQSQNDLPQDVGDRGLIDTLEDTGMAVADIRRQELTRMDEALGRLKEGRYGFCDECGAEIDEGRLRVAPYAPCCISCQTRREGPSYGPGVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WZ4</accession>
    <name>Q39WZ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NUDIX hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514383.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0988"/>
    <dbReference type="EnsemblBacteria" id="ABB31230">
        <property type="protein sequence ID" value="ABB31230"/>
        <property type="gene ID" value="Gmet_0988"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0988"/>
    <dbReference type="eggNOG" id="COG1051">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_20_3_7"/>
    <dbReference type="OMA" id="NRDPRGH"/>
    <dbReference type="OrthoDB" id="1846332at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="20"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="16616" checksum="C10A7629CA34908B" modified="2005-11-22" version="1">MSFDHLTCPRCGAEVKRYRNPVPTVDIIIETAGGIVLIERKNEPRGWALPGGFVDYGETLEAAAMREALEETSLHVTNLRLLGCYSDPARDPRQHTISTVYVAEASGVPAAADDAANLAVFPLNDLPSELCFDHRRILDDYLRFRERSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WZ8</accession>
    <name>Q39WZ8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Biotin carboxylase</fullName>
            <ecNumber evidence="9">6.3.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Acetyl-coenzyme A carboxylase biotin carboxylase subunit A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">accC</name>
        <name evidence="12" type="ordered locus">Gmet_0984</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 9">Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.14" evidence="9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514379.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0984"/>
    <dbReference type="EnsemblBacteria" id="ABB31226">
        <property type="protein sequence ID" value="ABB31226"/>
        <property type="gene ID" value="Gmet_0984"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0984"/>
    <dbReference type="eggNOG" id="COG0439">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_3_2_7"/>
    <dbReference type="OMA" id="FVEICSH"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004549">
        <property type="entry name" value="Acetyl_CoA_COase_biotin_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00514">
        <property type="entry name" value="accC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="11">
        <location>
            <begin position="1"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="10">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB31226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="446" mass="48892" checksum="B86370BC897F3160" modified="2005-11-22" version="1">MFHKVLIANRGEIALRVIRACKELGIKTVAVYSVADKDSLHVKLADESVCIGPAPSLQSYLNINAIISAAEVTDAEAIHPGYGFLSENAAFAEICENCGITFIGPSSESMRIMGDKISARQAVIKEDVPILPGTKEGVNDVNEAIKIAKGIGFPVIIKATAGGGGRGMKIVHSPATLPNAFATARAEAQAGFGNPEVYIEKYCEEPRHVEIQIMADKHGNVIHLGERDCSIQRRHQKIIEEAPCPVMTPNLRKAMGDAAVRAAKAVGYDSVGTVEFLVDKNLNFYFMEMNTRVQVEHPVTEMITGVDIVREQIRSAAGHKLRYKQGDVKIQGHAIECRINAEDPVKFTPCPGKITGYHTPGGLGVRVDSFVYDQYSVVPHYDSLISKLIVHAETREDAIRRMARALDEYIIEGIKTTIPFHKRIMANKDFMEGNVDTAFLEKIVLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X06</accession>
    <name>AROC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Chorismate synthase</fullName>
            <shortName evidence="1">CS</shortName>
            <ecNumber evidence="1">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroC</name>
        <name type="ordered locus">Gmet_0976</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21020"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="EC" id="4.2.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMNH2</name>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
        </cofactor>
        <text evidence="1">Reduced FMN (FMNH(2)).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the chorismate synthase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514371.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X06"/>
    <dbReference type="SMR" id="Q39X06"/>
    <dbReference type="STRING" id="269799.Gmet_0976"/>
    <dbReference type="EnsemblBacteria" id="ABB31218">
        <property type="protein sequence ID" value="ABB31218"/>
        <property type="gene ID" value="Gmet_0976"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0976"/>
    <dbReference type="eggNOG" id="COG0082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034547_2_0_7"/>
    <dbReference type="OMA" id="MLSINAV"/>
    <dbReference type="OrthoDB" id="981870at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="PTHR21085"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="SSF103263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00787">
        <property type="entry name" value="CHORISMATE_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000256295" description="Chorismate synthase">
        <location>
            <begin position="1"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="316"/>
            <end position="320"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00300"/>
        </source>
    </evidence>
    <sequence length="393" mass="42697" checksum="47AE093CBDF5DB55" modified="2005-11-22" version="1">MLRYLTAGESHGPQLTAIIEGIPAGLKISEETINVDLARRQGGYGRGGRMLIEKDQVQILSGVRWGETIGSPVTLCVVNRDWVNWQEKMSPHERHRDDKIRVTRSRPGHADLPGAMKYNHRDVRNILERSSARETAMRVAVGSVARAFLASFGVTVSGFVVELGGIKAERRGLSSDRLRELAAKSELATYDPEAEARMKAFIDSVKDAGDTAGGVVEVVVTGAPVGLGSHVQWDRKLDARLAMAVMSIQAIKGVEIGLGFETARRPGSQVHDEIYFDSSRIAHGEATGFFRKTNNAGGIEGGITNGEEIVIRAAMKPIPTLYKPLSSVDMLTKEPFEATVERSDVCAVPAAAVVAESVVAIEIASAFLEKFGGDSLAEIRRNYDGYLDYLRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X75</accession>
    <name>Q39X75_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0907</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513937.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31149">
        <property type="protein sequence ID" value="ABB31149"/>
        <property type="gene ID" value="Gmet_0907"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0907"/>
    <dbReference type="HOGENOM" id="CLU_149937_0_0_7"/>
    <dbReference type="OMA" id="MIQVRTR"/>
    <dbReference type="OrthoDB" id="1914006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223582" evidence="1">
        <location>
            <begin position="30"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="16797" checksum="657419533ED9F10A" modified="2005-11-22" version="1">MKRSWGIWALTAALTIMAPSAVPVSPAYAADDQWVLLDEDPSTSRYYYDTTSIVQDDEDSVTVRTKAVYTAEGKADALDTIGHPKGFEDLADTNFYYTINCSDDMSRLEKVVHRDSTGRTIKEYLLAGKTPWEQIEADTRMSLLRDAVCD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X89</accession>
    <name>TRMFO_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO</fullName>
            <ecNumber evidence="1">2.1.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Folate-dependent tRNA (uracil-5-)-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Folate-dependent tRNA(M-5-U54)-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">trmFO</name>
        <name type="synonym">gid</name>
        <name type="ordered locus">Gmet_0893</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:16873"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH + uridine(54) in tRNA = (6S)-5,6,7,8-tetrahydrofolate + 5-methyluridine(54) in tRNA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:62372"/>
            <dbReference type="Rhea" id="RHEA-COMP:10167"/>
            <dbReference type="Rhea" id="RHEA-COMP:10193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74447"/>
            <dbReference type="EC" id="2.1.1.74"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MnmG family. TrmFO subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.74" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513040.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X89"/>
    <dbReference type="SMR" id="Q39X89"/>
    <dbReference type="STRING" id="269799.Gmet_0893"/>
    <dbReference type="EnsemblBacteria" id="ABB31135">
        <property type="protein sequence ID" value="ABB31135"/>
        <property type="gene ID" value="Gmet_0893"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0893"/>
    <dbReference type="eggNOG" id="COG1206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033057_1_0_7"/>
    <dbReference type="OMA" id="MHRNTFL"/>
    <dbReference type="OrthoDB" id="516534at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030698">
        <property type="term" value="F:5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047151">
        <property type="term" value="F:methylenetetrahydrofolate-tRNA-(uracil-5-)-methyltransferase (FADH2-oxidizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01037">
        <property type="entry name" value="TrmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002218">
        <property type="entry name" value="MnmG-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020595">
        <property type="entry name" value="MnmG-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040131">
        <property type="entry name" value="MnmG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004417">
        <property type="entry name" value="TrmFO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806">
        <property type="entry name" value="PTHR11806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11806:SF2">
        <property type="entry name" value="PTHR11806:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01134">
        <property type="entry name" value="GIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00137">
        <property type="entry name" value="gid_trmFO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01281">
        <property type="entry name" value="GIDA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0274">FAD</keyword>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_1000063914" description="Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO">
        <location>
            <begin position="1"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01037"/>
        </source>
    </evidence>
    <sequence length="434" mass="47144" checksum="2CD000F8FF69D2C1" modified="2005-11-22" version="1">MTDAITIIGGGLAGCEAVWQAAERGVRVTLHEMKPHAFSPAHHLAGLAELVCSNSLRGESLENAVGLLKEELRRAGSLIMAAADATRVPAGGALAVDRELFSAFVTERIENHPLVDLMRGEVADIPSEDIVIVATGPLTSDGLAERIRAITGPNLYFYDAIAPIVTAESLDMTKVFRASRYGKGDGDDYLNCPLNQEEYEGFVDAILAAEKVPARDFEKVVHFEGCMPVEEMAERGRETLRFGPLKPVGLADPRTGEEPHAVVQLRAENREGTMFNLVGFQTKLTYPEQRRIFRMIPGLENAEFVRLGSMHRNTFINAPALLAPTFQLKGDARILFAGQITGVEGYVESAGSGFLAGVNAARLVRGEEPVVPPLATALGALVTHITNADVKHFQPMNVNYGLFPPLEGKVKKKERRGKLAERALAELDRWIGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XC3</accession>
    <name>Q39XC3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365733.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0859"/>
    <dbReference type="EnsemblBacteria" id="ABB31101">
        <property type="protein sequence ID" value="ABB31101"/>
        <property type="gene ID" value="Gmet_0859"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0859"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_672256_0_0_7"/>
    <dbReference type="OMA" id="TEMHAPV"/>
    <dbReference type="OrthoDB" id="1802961at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="494" mass="52704" checksum="82ACB1CF04959C77" modified="2005-11-22" version="1">MITILFISDDTRVPDLIARVQSQLKARMRLATDFDQGLKEVFDNRPSAVFIQGDISGISGETVARHIKTLLRGDAPRIVLIHTAPLPTQGVKKWFDDAIDFSLPQAELADQFKLRLMEIAPDLRIETNDVPTRHAGNVAAAAPNVSDHPAPSHGEAEPFDWEAPGDAVPHAVQPPCHQAHSEVEERDESDSLPDVSQVLVGRGAATTGPGMPSPGSELRNVMPSIIEESATTQSTFSEQIPSTPATPSPPLTPLREAEPKPAPLRQPSPLQAVESSRERTAASMADFSAEMTKEAKAEWVTIPPPDRELGGATGQRLTVWAAAIVVLLLGAMVGGALLLKGEGNKKKPSPKPEAMQTAPTRTSPAPAPPAKAIPLKTTPAALPSFIPASGKDEGFGKVHPGWERYLGRGTEYRLFRENGRLKAVQVIALRGTAVPDTLVVAVVRELTGSERLGAVSSQTKKGGYLRQVGKVDGKGEVVIYRKGGGVRGVVVTLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XF0</accession>
    <name>Q39XF0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH:quinone oxidoreductase family protein PIG3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512976.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0832"/>
    <dbReference type="EnsemblBacteria" id="ABB31074">
        <property type="protein sequence ID" value="ABB31074"/>
        <property type="gene ID" value="Gmet_0832"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0832"/>
    <dbReference type="eggNOG" id="COG0604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_3_4_7"/>
    <dbReference type="OMA" id="VWSNVFM"/>
    <dbReference type="OrthoDB" id="1027479at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05276">
        <property type="entry name" value="p53_inducible_oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="PKS_ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014189">
        <property type="entry name" value="Quinone_OxRdtase_PIG3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02824">
        <property type="entry name" value="quinone_pig3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKS_ER" evidence="1">
        <location>
            <begin position="10"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="328" mass="35210" checksum="3D2EB6497C3E180A" modified="2005-11-22" version="1">MKAVLLNGFGGLDVLTVGEVERPKPGEGQVLVKVVATSINRPDLVQREGKYPPPPGDSEILGLEVSGTVEELGPGVTGWQVGDRVMTLVGGGAYAEYAVAYASHLMRIPESMSFEEAACVCESCITAFLNVFMIGGLKDNNTVILHGGGGGVNTAGLQLCKALVPNTKIIVTSHPSKMARVKELGADLVIDFTQTPDFSEAVKEFTNKKGADVILDHVGAKYLAPNMNSLAYAGRLVIIGVISGIKAELNLALMMVKRQQIIGSVLRSRPVKDKGEIVAEFTRTALPKFADRTIVPIIEKVFTIDQVVEAHRMMEEDKHFGKIVLKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XT3</accession>
    <name>Q39XT3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-synthase/beta-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">metC-2</name>
        <name evidence="4" type="ordered locus">Gmet_0699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514090.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0699"/>
    <dbReference type="EnsemblBacteria" id="ABB30941">
        <property type="protein sequence ID" value="ABB30941"/>
        <property type="gene ID" value="Gmet_0699"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0699"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_7"/>
    <dbReference type="OMA" id="EVTWTDP"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="378" mass="41039" checksum="535A30A13DECD72E" modified="2005-11-22" version="1">MKFGTRIIHTGHDIDPTTGAVSIPIYQTSTFRQESVDHFGKYDYARSDNPTREALEETIAQLEGGTRGFAYASGMAAISSVLLLFSPGDHLVVCEDVYGGTFRVLTQLFSRLGITSTFVDATDLDAIAAAFRPETKGLFLESPSNPLLKITDLEGAARIARERGAITLVDNTFMTPYLQRPLEVGCDIVLHSGTKFLNGHSDVICGFAVVKDPELGKRIRFIQNAFGAILGPQDSWLVLRGLKTLRVRMEESQRSATRIASWLAGEKRVTRVLYPGLPSHPGHAIHARQSSGPGAVLSFALDSLEVTRRLLEGMKLAAFAVSLGGVESIISYPARMSHAAMPPEERAARGIGDTLVRLSVGLEEADDLIAEMDRLING</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XX8</accession>
    <name>RL17_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplQ</name>
        <name type="ordered locus">Gmet_0654</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L32.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514262.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XX8"/>
    <dbReference type="SMR" id="Q39XX8"/>
    <dbReference type="STRING" id="269799.Gmet_0654"/>
    <dbReference type="EnsemblBacteria" id="ABB30896">
        <property type="protein sequence ID" value="ABB30896"/>
        <property type="gene ID" value="Gmet_0654"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0654"/>
    <dbReference type="eggNOG" id="COG0203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074407_0_1_7"/>
    <dbReference type="OMA" id="YAVTELF"/>
    <dbReference type="OrthoDB" id="1838961at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01368">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000456">
        <property type="entry name" value="Ribosomal_L17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036373">
        <property type="entry name" value="Ribosomal_L17_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14413">
        <property type="entry name" value="PTHR14413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01196">
        <property type="entry name" value="Ribosomal_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64263">
        <property type="entry name" value="SSF64263"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00059">
        <property type="entry name" value="L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01167">
        <property type="entry name" value="RIBOSOMAL_L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000267874" description="50S ribosomal protein L17">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="178" mass="19602" checksum="FFE149DF18F9D672" modified="2005-11-22" version="1">MRHNKAGRRLGRTTSHRIAMFRNMVTSFLEHERITTTDAKAKELRSIAEKMITLGKRGDLHAQRQAASYIRDKKVVTKLFSTIAPRYKERDGGYTRIIKLGIRPGDNAPLSVIELVEEQVNKKEKKAKPAKAAIVATAPAVEQAAVLTSPADEPVVAEENAPQSAVKDAVDECEGKAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XY7</accession>
    <name>RL15_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplO</name>
        <name type="ordered locus">Gmet_0645</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds to the 23S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365701.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XY7"/>
    <dbReference type="SMR" id="Q39XY7"/>
    <dbReference type="STRING" id="269799.Gmet_0645"/>
    <dbReference type="EnsemblBacteria" id="ABB30887">
        <property type="protein sequence ID" value="ABB30887"/>
        <property type="gene ID" value="Gmet_0645"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0645"/>
    <dbReference type="eggNOG" id="COG0200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055188_4_2_7"/>
    <dbReference type="OMA" id="FKNINRV"/>
    <dbReference type="OrthoDB" id="1874945at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="L18e/L15P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_L15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_L15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_L18e/L15P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="PTHR12934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="SSF52080"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000251516" description="50S ribosomal protein L15">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="148" mass="15655" checksum="89070ED8E2875F86" modified="2005-11-22" version="1">MELNNLKPAIGATKDRKRIGRGTGSGHGKTATKGHKGQKARSGGSIKAGFEGGQMPMQRRLPKRGFTPLMRKDYAIVNIGQLDVFESGSTVDAEALLNAGLISGVKDGIKVLADGDVTKSLVVKVHKYSAKAKEKIEAVGGKIEEITL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y13</accession>
    <name>RPOB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta</fullName>
            <shortName evidence="1">RNAP subunit beta</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoB</name>
        <name type="ordered locus">Gmet_0619</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514635.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y13"/>
    <dbReference type="SMR" id="Q39Y13"/>
    <dbReference type="STRING" id="269799.Gmet_0619"/>
    <dbReference type="EnsemblBacteria" id="ABB30861">
        <property type="protein sequence ID" value="ABB30861"/>
        <property type="gene ID" value="Gmet_0619"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0619"/>
    <dbReference type="eggNOG" id="COG0085">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_4_0_7"/>
    <dbReference type="OMA" id="FMTWEGY"/>
    <dbReference type="OrthoDB" id="9601at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01321">
        <property type="entry name" value="RNApol_bact_RpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042107">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_ext_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019462">
        <property type="entry name" value="DNA-dir_RNA_pol_bsu_external_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010243">
        <property type="entry name" value="RNA_pol_bsu_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="PTHR20856"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10385">
        <property type="entry name" value="RNA_pol_Rpb2_45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02013">
        <property type="entry name" value="rpoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000237301" description="DNA-directed RNA polymerase subunit beta">
        <location>
            <begin position="1"/>
            <end position="1370"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01321"/>
        </source>
    </evidence>
    <sequence length="1370" mass="152879" checksum="1CB760929BA37A23" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y18</accession>
    <name>Q39Y18_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Transcription termination/antitermination protein NusG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">nusG</name>
        <name evidence="9" type="ordered locus">Gmet_0614</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Participates in transcription elongation, termination and antitermination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the NusG family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514630.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0614"/>
    <dbReference type="EnsemblBacteria" id="ABB30856">
        <property type="protein sequence ID" value="ABB30856"/>
        <property type="gene ID" value="Gmet_0614"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0614"/>
    <dbReference type="eggNOG" id="COG0250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_067287_1_0_7"/>
    <dbReference type="OMA" id="DGPFNGF"/>
    <dbReference type="OrthoDB" id="2027986at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006354">
        <property type="term" value="P:DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00948">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006645">
        <property type="entry name" value="NGN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043425">
        <property type="entry name" value="NusG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001062">
        <property type="entry name" value="Transcrpt_antiterm_NusG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015869">
        <property type="entry name" value="Transcrpt_antiterm_NusG_bac_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265">
        <property type="entry name" value="PTHR30265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30265:SF2">
        <property type="entry name" value="PTHR30265:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02357">
        <property type="entry name" value="NusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00338">
        <property type="entry name" value="NUSGTNSCPFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00738">
        <property type="entry name" value="NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82679">
        <property type="entry name" value="SSF82679"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00922">
        <property type="entry name" value="nusG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01014">
        <property type="entry name" value="NUSG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5 6" id="KW-0889">Transcription antitermination</keyword>
    <keyword evidence="3 5 6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1 5 6" id="KW-0806">Transcription termination</keyword>
    <feature type="domain" description="NGN" evidence="7">
        <location>
            <begin position="2"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="8">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="175" mass="19812" checksum="8DBFEEBEF9933402" modified="2005-11-22" version="1">MAKKWYGVHTYSGFENKVRLSLSERIKNLGLEESFGEILIPSETVVELKKGEKKTSSRKFFPGYILVNMELSDETWHVVKETSKVTGFVGGNNPFAIPDEEVAKITRRMEEGAEKPRPKVQFEVGETVRVVDGPFLNFTGVVEDVKPDKGKLRVMVSIFGRATPVELEFMQVEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y43</accession>
    <name>Q39Y43_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512286.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0588"/>
    <dbReference type="EnsemblBacteria" id="ABB30831">
        <property type="protein sequence ID" value="ABB30831"/>
        <property type="gene ID" value="Gmet_0588"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0588"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011615_5_0_7"/>
    <dbReference type="OMA" id="AWISQRK"/>
    <dbReference type="OrthoDB" id="1075011at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="449"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="613" mass="68174" checksum="25664DF029B0EFCD" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y80</accession>
    <name>Q39Y80_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, A protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tklA</name>
        <name evidence="2" type="ordered locus">Gmet_0551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30794.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365680.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0551"/>
    <dbReference type="EnsemblBacteria" id="ABB30794">
        <property type="protein sequence ID" value="ABB30794"/>
        <property type="gene ID" value="Gmet_0551"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0551"/>
    <dbReference type="eggNOG" id="COG3959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_4_1_7"/>
    <dbReference type="OMA" id="MVHAVNS"/>
    <dbReference type="OrthoDB" id="1543182at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02012">
        <property type="entry name" value="TPP_TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRANSKETOLASE_1" evidence="1">
        <location>
            <begin position="12"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30794.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="277" mass="29731" checksum="9FC5F20C71CF9768" modified="2012-10-31" version="2">MDSEKIAQLQEKARQLRVDIVKTLHKSQSGHTGGSLSAIDMVTALYFQVMKHNPADPAWPGRDRFVLCKGHAAPALYVALAEAGYFPKEDLMTLRRLGSHLQGHPDSKQTPGVEVCTGSLGQGLSMANGMALGLRLDGSSSRVYALLGDGELQEGQVWEAAMAAGHYKLDNLCALVDVNRLQIDGEVAKVMAVEPVTDKFRAFGWNVIDIDGHDMGAIVTALGQAAEAKGKPTVIVARTVKGKGVSFFENKASYHGVAPSDEELPKALECLGEQCYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y98</accession>
    <name>Q39Y98_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512229.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0533"/>
    <dbReference type="EnsemblBacteria" id="ABB30776">
        <property type="protein sequence ID" value="ABB30776"/>
        <property type="gene ID" value="Gmet_0533"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0533"/>
    <dbReference type="HOGENOM" id="CLU_2219367_0_0_7"/>
    <dbReference type="OMA" id="KKIMMSI"/>
    <dbReference type="OrthoDB" id="2015932at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223439" evidence="1">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="104" mass="10547" checksum="813E045F328905B3" modified="2005-11-22" version="1">MKKIMMSIAAALVAVSMAAVAFASGSFSGKVTKIDGAKVTVKADKIPAWVKKGGSVSAMGGSPKVLDVKGNEVTLRFGKAKADKVKVDSSLTVSEASGDELQGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YC5</accession>
    <name>Q39YC5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512202.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0506"/>
    <dbReference type="EnsemblBacteria" id="ABB30749">
        <property type="protein sequence ID" value="ABB30749"/>
        <property type="gene ID" value="Gmet_0506"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0506"/>
    <dbReference type="eggNOG" id="COG4980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105320_5_3_7"/>
    <dbReference type="OMA" id="YDGGDCW"/>
    <dbReference type="OrthoDB" id="2050379at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="80" mass="8348" checksum="1D93D0E0DB08F72A" modified="2005-11-22" version="1">MSDKNTETAAILAFFAGAALAAGAALLLTPKTGREVREKLGDVTEDAVGKIRSAVREAKYKVAPKAKDEPGDIEGGSCWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YD5</accession>
    <name>Q39YD5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0496</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512192.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0496"/>
    <dbReference type="EnsemblBacteria" id="ABB30739">
        <property type="protein sequence ID" value="ABB30739"/>
        <property type="gene ID" value="Gmet_0496"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0496"/>
    <dbReference type="eggNOG" id="COG3350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_168222_0_1_7"/>
    <dbReference type="OMA" id="TFQDPVC"/>
    <dbReference type="OrthoDB" id="1964436at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="95" mass="10922" checksum="B1CD82132A46B4A7" modified="2005-11-22" version="1">MRLIIMLILFYVGFRIVQGFLKKKQEEKPTIPAPEKEETFQDPVCGVYVTEDDAVIGRHEGKRIHFCSMACLEKYQAGLEHAGTTHNQSNPEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YD6</accession>
    <name>Q39YD6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase</fullName>
            <ecNumber evidence="3">2.7.6.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">folK</name>
        <name evidence="14" type="ordered locus">Gmet_0495</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of pyrophosphate from adenosine triphosphate (ATP) to 6-hydroxymethyl-7,8-dihydropterin, an enzymatic step in folate biosynthesis pathway.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HPPK family.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.3" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30738.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512191.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0495"/>
    <dbReference type="EnsemblBacteria" id="ABB30738">
        <property type="protein sequence ID" value="ABB30738"/>
        <property type="gene ID" value="Gmet_0495"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0495"/>
    <dbReference type="eggNOG" id="COG0801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097916_1_2_7"/>
    <dbReference type="OMA" id="QVILRQN"/>
    <dbReference type="OrthoDB" id="1953248at2"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00155"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003848">
        <property type="term" value="F:2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00483">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000550">
        <property type="entry name" value="Hppk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035907">
        <property type="entry name" value="Hppk_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01288">
        <property type="entry name" value="HPPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55083">
        <property type="entry name" value="SSF55083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01498">
        <property type="entry name" value="folK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPPK" evidence="13">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30738.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="162" mass="18322" checksum="052865B65B50CD5C" modified="2012-10-31" version="2">MKSNVFIALGSNQGDRELNLLRAVAEIGRLEQTRITALSGFYDTDPVGPVDQPNFLNAALRLETALSPRQLLAELQRIETDVFRRVRDVPWGPRSMDLDILLYGDLILDEEGLVIPHPRLHERRFVLVPLAEIAPDVHHPLLGKRVDELLRSLPPGERVTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YE7</accession>
    <name>Q39YE7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cobalt-precorrin-5A hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbiG</name>
        <name evidence="4" type="ordered locus">Gmet_0484</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513853.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0484"/>
    <dbReference type="DNASU" id="3738317"/>
    <dbReference type="EnsemblBacteria" id="ABB30727">
        <property type="protein sequence ID" value="ABB30727"/>
        <property type="gene ID" value="Gmet_0484"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0484"/>
    <dbReference type="eggNOG" id="COG2073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028397_0_0_7"/>
    <dbReference type="OMA" id="GIGCNRG"/>
    <dbReference type="OrthoDB" id="1617773at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021745">
        <property type="entry name" value="CbiG_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021744">
        <property type="entry name" value="CbiG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002750">
        <property type="entry name" value="CobE/GbiG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036518">
        <property type="entry name" value="CobE/GbiG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038029">
        <property type="entry name" value="GbiG_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01890">
        <property type="entry name" value="CbiG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11761">
        <property type="entry name" value="CbiG_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11760">
        <property type="entry name" value="CbiG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159664">
        <property type="entry name" value="SSF159664"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159672">
        <property type="entry name" value="SSF159672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiG_N" evidence="2">
        <location>
            <begin position="53"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_mid" evidence="3">
        <location>
            <begin position="137"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="CbiG_C" evidence="1">
        <location>
            <begin position="230"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="351" mass="36703" checksum="5B3C61EC841EE7E6" modified="2005-11-22" version="1">MRIAIIAITRNGARLGTQLRDGLGSAELYVLQKFAGQAGTGAVPFAGELKGLVAELWPAFDGFVFIMATGIVVRMVAPHLVAKDLDPAVVVMDDAGKFAVSLLSGHLGGANELACRCAFVTGAREVITTATDANNLPSFDMLAKEEGWAIDDLCRVKTLNALILEGEEIAVVDPTDRVRTAFHGTARLTFHDTFVEALQSGAKGFVFVTNRRLPPQAQADSLLILRPRNLALGIGCNSGTGAEEIAAVVGAQMKRLFLSLKSVACIGSAVAKQDEAGLLAFAREHGLPLRFFESGELNSVTVPSPPSAHALEAIGATGVAEPAAVLASNGGRLLLKKIKSGNVTLAIAEIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YI5</accession>
    <name>Q39YI5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0446"/>
    <dbReference type="EnsemblBacteria" id="ABB30689">
        <property type="protein sequence ID" value="ABB30689"/>
        <property type="gene ID" value="Gmet_0446"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0446"/>
    <dbReference type="HOGENOM" id="CLU_1852315_0_0_7"/>
    <dbReference type="OMA" id="GMETIRD"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008622">
        <property type="entry name" value="FliT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05400">
        <property type="entry name" value="FliT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="138" mass="15286" checksum="AD5C259F6901A457" modified="2005-11-22" version="1">MSMTLGDLLVDAERQSSLLLQEAEKLLRDLDIIADDELAQLLARRQEIVDWFQNFDVRLYDCMDGSPDAQAAVAKFRICQKETMERILEIDAMTVALAKGRLASIGDALAACAKEAKVLSAYGETVGGTRRHRLDSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YJ2</accession>
    <name>Q39YJ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flagellar hook-filament junction protein FlgL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">flgL</name>
        <name evidence="7" type="ordered locus">Gmet_0439</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Bacterial flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial flagellin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512411.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0439"/>
    <dbReference type="EnsemblBacteria" id="ABB30682">
        <property type="protein sequence ID" value="ABB30682"/>
        <property type="gene ID" value="Gmet_0439"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0439"/>
    <dbReference type="eggNOG" id="COG1344">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024437_2_1_7"/>
    <dbReference type="OMA" id="MRVTQGM"/>
    <dbReference type="OrthoDB" id="1788350at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009424">
        <property type="term" value="C:bacterial-type flagellum hook"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013384">
        <property type="entry name" value="Flagell_FlgL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001492">
        <property type="entry name" value="Flagellin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046358">
        <property type="entry name" value="Flagellin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001029">
        <property type="entry name" value="Flagellin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42792">
        <property type="entry name" value="PTHR42792"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00700">
        <property type="entry name" value="Flagellin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00669">
        <property type="entry name" value="Flagellin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02550">
        <property type="entry name" value="flagell_flgL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flagellin_N" evidence="5">
        <location>
            <begin position="5"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Flagellin_C" evidence="6">
        <location>
            <begin position="211"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="294" mass="31453" checksum="F9EDA868F8EBA23D" modified="2005-11-22" version="1">MRVTQNTTANLVTNNLQTIRKRTEDLQQQASTGYKVSTASDDPVTAQQILHMKSLMTAGDQYARNISNGIAWLTMSEGAMSELGNVITRAKELAVAMSSETNNANSRAAAVNEFKELKAQIITLGNTQLNGRYIFGGFKNDTPPFDASGNFNGTDDAIMVEVDRGSSVQMNYSGGQLIRGTGGGTDIISSLDNIINALGADNTSGVQAELSTLDNALGQVLATRTDLGARMSHFNAANNIVNDMKLSLTKITSDKQDIDLMQVISDLSKQQTAYQAAVAASAKVSQVSLLDYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YK3</accession>
    <name>Q39YK3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flagellar biogenesis ATPase FlhG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">flhG</name>
        <name evidence="4" type="ordered locus">Gmet_0428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512400.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0428"/>
    <dbReference type="EnsemblBacteria" id="ABB30671">
        <property type="protein sequence ID" value="ABB30671"/>
        <property type="gene ID" value="Gmet_0428"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0428"/>
    <dbReference type="eggNOG" id="COG0455">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_0_0_7"/>
    <dbReference type="OMA" id="FKVAKNN"/>
    <dbReference type="OrthoDB" id="1370117at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02038">
        <property type="entry name" value="FlhG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033875">
        <property type="entry name" value="FlhG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025501">
        <property type="entry name" value="MinD_FleN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003092">
        <property type="entry name" value="MinD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="4" id="KW-0282">Flagellum</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="3">
        <location>
            <begin position="42"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="311" mass="33489" checksum="F932B396E2B85F62" modified="2005-11-22" version="1">MNVTATTGDQADSLRQLATSVNKKRKASAARALEGQSLKGIRVISVTSGKGGVGKSNVVVNLALALAGKGKKVLVIDADLGLGNIDVLLGLTPDYTLNDVFAGRKRLEEIIIEGPGGIRIIPAGSGLPDFTSLGLQERVKIMDELDALEEDFDILIVDTGAGISENVAYFNTASQEIVVVVTPEPTSITDVYALIKLLATRHSERYFKVLVNMARDTDDALQVFAKLSNVTSRFLDISLDYLGCVLRDDAILEAVKSQKPVIELLPDSPAAGCFATLARRILENGGEHRLKGNVQFFFRRFLSADAEMENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YR4</accession>
    <name>Q39YR4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">FtsK/SpoIIIE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ordered locus">Gmet_0367</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homohexamer. Forms a ring that surrounds DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FtsK/SpoIIIE/SftA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512339.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0367"/>
    <dbReference type="EnsemblBacteria" id="ABB30610">
        <property type="protein sequence ID" value="ABB30610"/>
        <property type="gene ID" value="Gmet_0367"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0367"/>
    <dbReference type="eggNOG" id="COG1674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001981_9_7_7"/>
    <dbReference type="OMA" id="WEVMAFE"/>
    <dbReference type="OrthoDB" id="349533at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025199">
        <property type="entry name" value="FtsK_4TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041027">
        <property type="entry name" value="FtsK_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002543">
        <property type="entry name" value="FtsK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018541">
        <property type="entry name" value="Ftsk_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13491">
        <property type="entry name" value="FtsK_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17854">
        <property type="entry name" value="FtsK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09397">
        <property type="entry name" value="FtsK_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01580">
        <property type="entry name" value="FtsK_SpoIIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00843">
        <property type="entry name" value="Ftsk_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50901">
        <property type="entry name" value="FTSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="151"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="FtsK" evidence="14">
        <location>
            <begin position="391"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="200"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="200"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="408"/>
            <end position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB30610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="760" mass="83949" checksum="1BB70C3784DE74DF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="126" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YT0</accession>
    <name>Q39YT0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="10">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
            <shortName evidence="10">IleRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 15" type="primary">ileS</name>
        <name evidence="15" type="ordered locus">Gmet_0351</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512322.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0351"/>
    <dbReference type="EnsemblBacteria" id="ABB30594">
        <property type="protein sequence ID" value="ABB30594"/>
        <property type="gene ID" value="Gmet_0351"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0351"/>
    <dbReference type="eggNOG" id="COG0060">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001493_7_0_7"/>
    <dbReference type="OMA" id="HLGTAWN"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02002">
        <property type="entry name" value="Ile_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023585">
        <property type="entry name" value="Ile-tRNA-ligase_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1" evidence="12">
        <location>
            <begin position="27"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="Anticodon_1" evidence="14">
        <location>
            <begin position="684"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="zf-FPG_IleRS" evidence="13">
        <location>
            <begin position="892"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="10">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="10">
        <location>
            <begin position="601"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="560"/>
        </location>
        <ligand>
            <name>L-isoleucyl-5'-AMP</name>
            <dbReference type="ChEBI" id="CHEBI:178002"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="604"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="895"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="898"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="915"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="918"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB30594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="923" mass="103598" checksum="7BCF7E69BF1B2E7F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z19</accession>
    <name>Q39Z19_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Twitching motility pilus retraction ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilT-2</name>
        <name evidence="3" type="ordered locus">Gmet_0260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513577.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0260"/>
    <dbReference type="EnsemblBacteria" id="ABB30505">
        <property type="protein sequence ID" value="ABB30505"/>
        <property type="gene ID" value="Gmet_0260"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0260"/>
    <dbReference type="eggNOG" id="COG2805">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_4_0_7"/>
    <dbReference type="OMA" id="RGQVHEI"/>
    <dbReference type="OrthoDB" id="473670at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006321">
        <property type="entry name" value="PilT/PilU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01420">
        <property type="entry name" value="pilT_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="356" mass="40084" checksum="2621836292AFFBB6" modified="2005-11-22" version="1">MDMNLLNQILGIAFEKRVSDLHFEVDNPPFFRAKGQLLRSKLPRLTPQDTEFIAKTVLEQNRRTFPDNLRELDASYSLPNGGRFRVSIFRQRGAIGIVMRVIPPHVGSFEELNLPPVLGEIAKAPNGLVLVTGPTGNGKSTTLASMLRHLNETCSFNIITIEDPIEFLFTSDRSCIIQREVGIDTENFSAALRSALRMDPDVIMVGEMRDLETIDSCIKAAETGHLVFSTLHTQSAVSTINRLIGHFPPDAQEVLRQRLADILVATVSLRLIKDKSGENILPVVEIMRATTTIQACIREGRLDEIEKHIENGRSLYHMQTLDQHLLELCEKEIITFDQAKQITRSMDLERKLAFTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z35</accession>
    <name>Q39Z35_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513560.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0244"/>
    <dbReference type="EnsemblBacteria" id="ABB30489">
        <property type="protein sequence ID" value="ABB30489"/>
        <property type="gene ID" value="Gmet_0244"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0244"/>
    <dbReference type="eggNOG" id="COG1874">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1110172_0_0_7"/>
    <dbReference type="OMA" id="IFQNRYL"/>
    <dbReference type="OrthoDB" id="1280079at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="254" mass="27300" checksum="6B3FF3C0015C7F8D" modified="2005-11-22" version="1">MFASVKRAVLSVGAAVCMIFSSAIVSWGAGPLVVVDQGHGQRFLVEQKGELHLSGLAATLGEEGLQVTTGRERLTDESLAKAAALVISGPFEPLASEEVDAVIRFLERGGRVALMLHIGHPLAGLIHRVGGDFSNSVLHERQNVIDDNDITFRVRDLATHPLFSGLEQFSLYGGWALNGLTSLARTSAEAWVDLDGNRKLSAGDAADRFTVVAEGSIGSGRILIFGDDAIFQNRYLDENNTRLARNLAHWLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z57</accession>
    <name>Q39Z57_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Toxin, RelE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512810.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0221"/>
    <dbReference type="EnsemblBacteria" id="ABB30467">
        <property type="protein sequence ID" value="ABB30467"/>
        <property type="gene ID" value="Gmet_0221"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0221"/>
    <dbReference type="eggNOG" id="COG2026">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161929_0_0_7"/>
    <dbReference type="OMA" id="ITMSYRI"/>
    <dbReference type="OrthoDB" id="2028198at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007712">
        <property type="entry name" value="RelE/ParE_toxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035093">
        <property type="entry name" value="RelE/ParE_toxin_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143011">
        <property type="entry name" value="SSF143011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02385">
        <property type="entry name" value="RelE_StbE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="91" mass="10476" checksum="0DFC1096194E3015" modified="2005-11-22" version="1">MYSVTTSEQFLRQARKFFNKHPDLRPRFAAIFEALKLDPFQPGLGLHQLSGKLAGCHAVRLTYSYRITLTLLIAEKEIILLDIGSHDEVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z61</accession>
    <name>Q39Z61_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotide-binding HEPN domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512806.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0217"/>
    <dbReference type="EnsemblBacteria" id="ABB30463">
        <property type="protein sequence ID" value="ABB30463"/>
        <property type="gene ID" value="Gmet_0217"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0217"/>
    <dbReference type="eggNOG" id="COG2250">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123170_0_0_7"/>
    <dbReference type="OrthoDB" id="2025059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007842">
        <property type="entry name" value="HEPN_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05168">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00748">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50910">
        <property type="entry name" value="HEPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HEPN" evidence="1">
        <location>
            <begin position="12"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="133" mass="14514" checksum="26A90DB7F3AF7096" modified="2005-11-22" version="1">MKPETAELTSKADADLATAQREASVDDAPNFDEVCFHAQQCAEKYLKAIMVETGVRVPRIHDLEALVNLLFGEYPGLERILRFARILSAMAVEVRYPGMTADEDDATESLKAATLIREAVQEILCGSGDAGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZC0</accession>
    <name>Q39ZC0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">NADH dehydrogenase I, F subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nuoF-2</name>
        <name evidence="13" type="ordered locus">Gmet_0157</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512744.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0157"/>
    <dbReference type="EnsemblBacteria" id="ABB30404">
        <property type="protein sequence ID" value="ABB30404"/>
        <property type="gene ID" value="Gmet_0157"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0157"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_0_1_7"/>
    <dbReference type="OMA" id="CREGTDW"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH_4Fe-4S" evidence="12">
        <location>
            <begin position="327"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB30404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="422" mass="45651" checksum="5B3D1FE864DB0D51" modified="2005-11-22" version="1">MEQLLFRHNRPGRCVTFAEYRAEGGFAALEKALAGMSPNDVQQVVIDSGLRGRGGAGFPTGKKWSFVPRDIPGPRYLICNCDEMEPGTYKDRVLLEANPYSLVEGMTLAAYAIGVAHAFIFIRRGYEEAAENCRRAIAEAKAAGLLGENILGTGFSLELDVHQSAGRYICGEETALMNALEGKRANPRSKPPFPAVKGLWGRPTVVNNVETLANIPAIVANGAAWFKGLARIPEAAGMKLFCVSGHVNNTACFELPLGMTLGEIIDGPCGGMLPGREFKACIPGGASTPFFTKEHWHVPMDFDTVAKAGSRLGTGGIVVFDRDTCMVAATLNLIVFYARESCGWCTPCREGLPFVQDVLARIEAGEGREEHIGILREHIQYLNYSFCPLAPGAMGPVEGLLRLFEGEIREHIVLGRCPFGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZD4</accession>
    <name>Q39ZD4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ResC/HemX-like cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0141</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512726.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0141"/>
    <dbReference type="EnsemblBacteria" id="ABB30390">
        <property type="protein sequence ID" value="ABB30390"/>
        <property type="gene ID" value="Gmet_0141"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0141"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049710_2_2_7"/>
    <dbReference type="OMA" id="CWFGVNY"/>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="184"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="56"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="239" mass="26359" checksum="76A6ACCFFDE08AC6" modified="2005-11-22" version="1">MKWLLILSAGLYLFGAFRRPFFAAGLAAGAAYLAVRGIELGRLPLVGPHDTLAFFSVSIGLMALPFLLSPALRQQSFFSWGMGCAAALFGLMALLFPAFAMPLPPVLRTLWFELHVALAFFSYALFAIGAVLGGIFLAGGERRILDLQYRAALVGYTFFSASMVSGGIWGYFAWGTYWLWTPKEFWTSILWIFYTFWLHLRLRGTGGDKALAWSGIVGFAVALFTYLGVSILMKSSHSF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZH2</accession>
    <name>GLMU_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein GlmU</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">UDP-N-acetylglucosamine pyrophosphorylase</fullName>
                <ecNumber evidence="1">2.7.7.23</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">N-acetylglucosamine-1-phosphate uridyltransferase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Glucosamine-1-phosphate N-acetyltransferase</fullName>
                <ecNumber evidence="1">2.3.1.157</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">glmU</name>
        <name type="ordered locus">Gmet_0103</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + alpha-D-glucosamine 1-phosphate = CoA + H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13725"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="ChEBI" id="CHEBI:58516"/>
            <dbReference type="EC" id="2.3.1.157"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route II): step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; LPS lipid A biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="1"/>
    <dbReference type="EC" id="2.3.1.157" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514108.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZH2"/>
    <dbReference type="SMR" id="Q39ZH2"/>
    <dbReference type="STRING" id="269799.Gmet_0103"/>
    <dbReference type="EnsemblBacteria" id="ABB30352">
        <property type="protein sequence ID" value="ABB30352"/>
        <property type="gene ID" value="Gmet_0103"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0103"/>
    <dbReference type="eggNOG" id="COG1207">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_15_2_7"/>
    <dbReference type="OMA" id="TAIVEHK"/>
    <dbReference type="OrthoDB" id="1381953at2"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00532"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00533"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00973"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019134">
        <property type="term" value="F:glucosamine-1-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03353">
        <property type="entry name" value="LbH_GlmU_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01631">
        <property type="entry name" value="GlmU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005882">
        <property type="entry name" value="Bifunctional_GlmU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038009">
        <property type="entry name" value="GlmU_C_LbH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025877">
        <property type="entry name" value="MobA-like_NTP_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12804">
        <property type="entry name" value="NTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000244294" description="Bifunctional protein GlmU">
        <location>
            <begin position="1"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyrophosphorylase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="254"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="12"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="80"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="386"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>UDP-N-acetyl-alpha-D-glucosamine</name>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="406"/>
            <end position="407"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="443"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01631"/>
        </source>
    </evidence>
    <sequence length="476" mass="50517" checksum="A9878B60A0F84673" modified="2005-11-22" version="1">MGDLAAIILAAGKGTRMKSDLVKVMHPLAGAPMVAWPVEAARQAGTSRMVLVVGHQADTIREHFAGTEQVAFALQEEQLGTGHAVASAAAALDGFTGRVLILCGDVPLIRPETLRGMIDAHGATGAALTVLTTRLENPFGYGRIIRGFDGRVIRIVEEKDATPEERGRREVNAGIYCAEAAFLFDAVTRIGNDNAQGEYYLTDIVTMANEQGLRCTAHPVADPVEVMGVNDRAQLAEAGRFARQRINRELMLDGVTIVDPAATYIDRGAVVGRDTTVHPGVHLSGETRIGEGCTIEQGAVIKGSTLGNGCVVEPGAVIRSCRLGSHVMVKAGSVMEDAIIHDHTAIGPMAHLRPGTELMAHVKIGNFVETKKITMGEGSKASHLTYLGDASIGNNVNVGCGTITCNYDGVRKHRTVIEDDVFVGSDVQFVAPVTVGRNSLIAAGTTVTRDVPPDSLAIARAPQVNKDGWKLKQRDQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZL5</accession>
    <name>ISPD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-diphosphocytidyl-2C-methyl-D-erythritol synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">MEP cytidylyltransferase</fullName>
            <shortName evidence="1">MCT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispD</name>
        <name type="ordered locus">Gmet_0060</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-C-methyl-D-erythritol 4-phosphate + CTP + H(+) = 4-CDP-2-C-methyl-D-erythritol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="EC" id="2.7.7.60"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.60" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514184.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZL5"/>
    <dbReference type="SMR" id="Q39ZL5"/>
    <dbReference type="STRING" id="269799.Gmet_0060"/>
    <dbReference type="EnsemblBacteria" id="ABB30309">
        <property type="protein sequence ID" value="ABB30309"/>
        <property type="gene ID" value="Gmet_0060"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0060"/>
    <dbReference type="eggNOG" id="COG1211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061281_2_2_7"/>
    <dbReference type="OMA" id="ERQHSVY"/>
    <dbReference type="OrthoDB" id="1836139at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00093"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050518">
        <property type="term" value="F:2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02516">
        <property type="entry name" value="CDP-ME_synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00108">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001228">
        <property type="entry name" value="IspD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034683">
        <property type="entry name" value="IspD/TarI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018294">
        <property type="entry name" value="ISPD_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01128">
        <property type="entry name" value="IspD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00453">
        <property type="entry name" value="ispD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01295">
        <property type="entry name" value="ISPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000237792" description="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase">
        <location>
            <begin position="1"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="15"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="1">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="site" description="Positions MEP for the nucleophilic attack" evidence="1">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00108"/>
        </source>
    </evidence>
    <sequence length="232" mass="25298" checksum="18A43C400DFD1036" modified="2005-11-22" version="1">MAVFALIPAAGMGKRMGASINKQYLLLGGMPILARTLEVFERSPLVDGIFVVIPADEIPFCREQVVERHGFSKVRSIVAGGAERQQSVLNGLRAMEGTAGEYDVILIHDGVRPFVTEDILGRATATARENDGALVAVPAKDTVKVVEDGIITATPSRETLWLAQTPQAFRYGVIRAAHEVADAERFLGTDDAMLVERLGRQVRIVLGDYRNVKITTPEDMVLAEAFIKEKLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZL7</accession>
    <name>Q39ZL7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glutamine--tRNA ligase</fullName>
            <ecNumber evidence="9">6.1.1.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutaminyl-tRNA synthetase</fullName>
            <shortName evidence="9">GlnRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 13" type="primary">glnS</name>
        <name evidence="13" type="ordered locus">Gmet_0058</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514182.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0058"/>
    <dbReference type="EnsemblBacteria" id="ABB30307">
        <property type="protein sequence ID" value="ABB30307"/>
        <property type="gene ID" value="Gmet_0058"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0058"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001882_2_3_7"/>
    <dbReference type="OMA" id="INNFCAQ"/>
    <dbReference type="OrthoDB" id="142899at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00126">
        <property type="entry name" value="Gln_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022861">
        <property type="entry name" value="Gln_tRNA_ligase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_L25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_L25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="SSF50715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="11">
        <location>
            <begin position="28"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA-synt_1c_C" evidence="12">
        <location>
            <begin position="340"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="9">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="9">
        <location>
            <begin position="268"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="41"/>
            <end position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="261"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="269"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB30307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="553" mass="63567" checksum="3DFE28610753E689" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZP0</accession>
    <name>Q39ZP0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallophosphoesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0034</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513800.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0034"/>
    <dbReference type="EnsemblBacteria" id="ABB30284">
        <property type="protein sequence ID" value="ABB30284"/>
        <property type="gene ID" value="Gmet_0034"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0034"/>
    <dbReference type="eggNOG" id="COG1408">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025443_0_1_7"/>
    <dbReference type="OMA" id="DTHYGPI"/>
    <dbReference type="OrthoDB" id="1690667at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Metallophos" evidence="2">
        <location>
            <begin position="156"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="375" mass="40855" checksum="D26C7F9B2B6C141D" modified="2005-11-22" version="1">MNLFLLVFFLVYGGTHAYFFVKARGAFGFGPSIGTLLAFFLALMAIAPVLVRITERQGWEFTACFLAWTGYLWMGLLFFFFSASLAMDLFHLVLKGGGTLLQRDPSLLIIGRRAAFGIAAAYAVLACLSSYMEARHIRSRRIVIPTTKLPATIPKLTIAQISDVHLGLIVRKERLENILARVREARPDIVVSTGDLVDGQINDLSALEKPLAELSPRYGKFAVTGNHEVYVGLDQAIGFTRRGGFTVLRGEGVTAGGVVNIAGVDDPATPSPPHAERNALAGLPADRFTILLKHRPRIDGETVGRFDLQLSGHVHGGQLFPFGLLVRLSYPYMDGFYRLANGSALSVSRGSGTWGPPLRFLAPPEVTIIELIPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZQ4</accession>
    <name>Q39ZQ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365618.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0020"/>
    <dbReference type="EnsemblBacteria" id="ABB30270">
        <property type="protein sequence ID" value="ABB30270"/>
        <property type="gene ID" value="Gmet_0020"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0020"/>
    <dbReference type="HOGENOM" id="CLU_2897780_0_0_7"/>
    <dbReference type="OMA" id="SCRENRA"/>
    <dbReference type="OrthoDB" id="2066092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="61" mass="6888" checksum="445532239BF88B2E" modified="2005-11-22" version="1">MEKETKACAICGNEFTPGEERTPYEEAGEWLATELWSDAGTLCPQCLDNRAKLAMMYVIDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-03-18" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZQ8</accession>
    <name>DCUP_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uroporphyrinogen decarboxylase</fullName>
            <shortName evidence="1">UPD</shortName>
            <shortName evidence="1">URO-D</shortName>
            <ecNumber evidence="1">4.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemE</name>
        <name type="ordered locus">Gmet_0016</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 H(+) + uroporphyrinogen III = 4 CO2 + coproporphyrinogen III</text>
            <dbReference type="Rhea" id="RHEA:19865"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57308"/>
            <dbReference type="ChEBI" id="CHEBI:57309"/>
            <dbReference type="EC" id="4.1.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the uroporphyrinogen decarboxylase family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.37" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513781.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZQ8"/>
    <dbReference type="SMR" id="Q39ZQ8"/>
    <dbReference type="STRING" id="269799.Gmet_0016"/>
    <dbReference type="EnsemblBacteria" id="ABB30266">
        <property type="protein sequence ID" value="ABB30266"/>
        <property type="gene ID" value="Gmet_0016"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0016"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_0_0_7"/>
    <dbReference type="OMA" id="LWLMRQA"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00321"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00717">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00218">
        <property type="entry name" value="URO_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006361">
        <property type="entry name" value="Uroporphyrinogen_deCO2ase_HemE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01464">
        <property type="entry name" value="hemE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00906">
        <property type="entry name" value="UROD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00907">
        <property type="entry name" value="UROD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0210">Decarboxylase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000325648" description="Uroporphyrinogen decarboxylase">
        <location>
            <begin position="1"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="23"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00218"/>
        </source>
    </evidence>
    <sequence length="340" mass="37773" checksum="3DFD6E143418AAFB" modified="2005-11-22" version="1">MNNRFLDACWGKPVDRTPVWLMRQAGRYLPEYMAVRSKCTFLELCKTPELAAEVTLQPVDILGVDAAILFSDILTPVEPMGLKLDFVPGPVFETPVRTMADVERLRIPNPEEDVPYVLDTIKILRKELAGRVPLIGFGGAPFTLACYMVEGKGSKDWATIKRMMYAAPEVYAALMDKVTMMDMEYLNAQIRAGAQAIQIFDTWGGVLSPTDYEKFVLPYTRKLINGLNRQNTPVIHFVKGAGTMLETVQKAGGDVMGLDWHVNLGKARDVLGPNMAVQGNLDPTVLYAPKEVIEVEVKRVLDENAGRPGHIFNLGHGILPTVPPENAIHMVECVHRLSQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZR4</accession>
    <name>Q39ZR4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0010</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513775.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0010"/>
    <dbReference type="EnsemblBacteria" id="ABB30260">
        <property type="protein sequence ID" value="ABB30260"/>
        <property type="gene ID" value="Gmet_0010"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0010"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="HALVWVI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="8">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="266"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="508" mass="55959" checksum="38BF023F242D4E41" modified="2005-11-22" version="1">MNNLKILIVDDEADIALILKLQLEDAGYRTTRARDGLEALEMLAREHYDLILLDIRMPRLDGIEVLERIRQEWPELVVVMMTAHGSEDIAVEAMKKGAVDYISKPFSSDDMKKRVERAIEYNRTRLENERLQREVEEERRKMEAILQGMAEALVAVDRQGLVMSINRTAAELFGVDAAAVHARPVEELLSAAIPADRLPCRVVLATGEPCLDVAYDLRLPGRIVPVLSSAAPLANAAGEMIGSVEIIRDISALKALEQEREDFVSMLSHDLKTPITAIIGSIDLVKEGRLGPVNPEQSMYLDAAVESCAEMVDMIDTLLDVHRFEAGRMVTTLVEEELGPLLQRTVGRFEPVARHSGLELTLSLPGAPVTFLVDRKQFGRLLGNLLSNALKFTTEGGIEVRAELPENAAAAAQGITPGAYPTERLPREGRYLLVSVSDTGAGIPADSLVTIFDRFVQARNRKMGKSSGTGLGLAFCRKVMDAHHGFIWAESEPDRGSTFRMLFPLGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYE6</accession>
    <name>J7LYE6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3597"/>
    <dbReference type="EnsemblBacteria" id="AFR42813">
        <property type="protein sequence ID" value="AFR42813"/>
        <property type="gene ID" value="Gmet_3597"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3597"/>
    <dbReference type="HOGENOM" id="CLU_3043830_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="54" mass="6095" checksum="F419CB05970A77C2" modified="2012-10-31" version="1">MFVNCYDGYGICLFSVTLKEGVEAKRLGNHIYSQHDLVDHWSVTTCPEGAVVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PR3</accession>
    <name>Q39PR3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 4-hydroxybenzoyl-CoA thioesterase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33761.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513712.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3556"/>
    <dbReference type="EnsemblBacteria" id="ABB33761">
        <property type="protein sequence ID" value="ABB33761"/>
        <property type="gene ID" value="Gmet_3556"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3556"/>
    <dbReference type="eggNOG" id="COG0824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101141_7_2_7"/>
    <dbReference type="OMA" id="YHASYLR"/>
    <dbReference type="OrthoDB" id="1786865at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008272">
        <property type="entry name" value="HB-CoA_thioesterase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006684">
        <property type="entry name" value="YbgC/YbaW"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003230">
        <property type="entry name" value="YbgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00051">
        <property type="entry name" value="TIGR00051"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01328">
        <property type="entry name" value="4HBCOA_THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4HBT" evidence="3">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33761.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="132" mass="14936" checksum="C84DA0936647D582" modified="2012-10-31" version="2">MEFRVYYEDTDAGGIVYHARYLGFFERGRCEFLRRRGLSVRELADEGAVFPVVRMEVDFRASAVLDDLLRVETEVLEVGKATFSLRQRVVRAEDGKTLVEGRVTLVCVRPGMKPRRLPEQLIGALRSTNGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PW0</accession>
    <name>Q39PW0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux pump, RND family, inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513665.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3509"/>
    <dbReference type="EnsemblBacteria" id="ABB33714">
        <property type="protein sequence ID" value="ABB33714"/>
        <property type="gene ID" value="Gmet_3509"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3509"/>
    <dbReference type="eggNOG" id="COG3696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_7"/>
    <dbReference type="OMA" id="INVFYDR"/>
    <dbReference type="OrthoDB" id="91817at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004763">
        <property type="entry name" value="CzcA/CusA/SilA/NccA/HelA/CnrA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00914">
        <property type="entry name" value="2A0601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="870"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="894"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="971"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1025"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1034" mass="113260" checksum="4F26C9C9C1F3D7D0" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PZ6</accession>
    <name>Q39PZ6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Maltokinase</fullName>
            <ecNumber evidence="5">2.7.1.175</ecNumber>
            <ecNumber evidence="6">5.4.99.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Maltose alpha-D-glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Maltose-1-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">treS</name>
        <name evidence="13" type="ordered locus">Gmet_3469</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-maltose = ADP + alpha-maltose 1-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31915"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63576"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.175"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-maltose = alpha,alpha-trehalose</text>
            <dbReference type="Rhea" id="RHEA:15145"/>
            <dbReference type="ChEBI" id="CHEBI:16551"/>
            <dbReference type="ChEBI" id="CHEBI:17306"/>
            <dbReference type="EC" id="5.4.99.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the aminoglycoside phosphotransferase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. TreS subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.175" evidence="5"/>
    <dbReference type="EC" id="5.4.99.16" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513920.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3469"/>
    <dbReference type="CAZy" id="GH13">
        <property type="family name" value="Glycoside Hydrolase Family 13"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33678">
        <property type="protein sequence ID" value="ABB33678"/>
        <property type="gene ID" value="Gmet_3469"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3469"/>
    <dbReference type="eggNOG" id="COG0366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007635_1_0_7"/>
    <dbReference type="OMA" id="QEDRFPI"/>
    <dbReference type="OrthoDB" id="1573900at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047471">
        <property type="term" value="F:maltose alpha-D-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="Glyco_hydro_13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040999">
        <property type="entry name" value="Mak_N_cap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032091">
        <property type="entry name" value="Malt_amylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012810">
        <property type="entry name" value="TreS/a-amylase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012811">
        <property type="entry name" value="TreS_maltokin_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18085">
        <property type="entry name" value="Mak_N_cap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16657">
        <property type="entry name" value="Malt_amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="SSF56112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02457">
        <property type="entry name" value="TreS_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02456">
        <property type="entry name" value="treS_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aamy" evidence="12">
        <location>
            <begin position="22"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB33678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1112" mass="127237" checksum="7212D4627A726549" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q07</accession>
    <name>Q39Q07_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513909.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3458"/>
    <dbReference type="EnsemblBacteria" id="ABB33667">
        <property type="protein sequence ID" value="ABB33667"/>
        <property type="gene ID" value="Gmet_3458"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3458"/>
    <dbReference type="eggNOG" id="ENOG5031KIR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102544_0_0_7"/>
    <dbReference type="OMA" id="CDTLDGP"/>
    <dbReference type="OrthoDB" id="1650162at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045613">
        <property type="entry name" value="DUF6448"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20046">
        <property type="entry name" value="DUF6448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223139" evidence="2">
        <location>
            <begin position="31"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="220" mass="23031" checksum="B66A717BF02FF1DC" modified="2005-11-22" version="1">MNTKNILSIKTAGIAAAIALSLALPQFASAHCDTLDGPVVQDARKAIEAKDITPVLKWVRPTDEHTVKSAFNAVLAAKGKNAEAAETRFFTTLVKVHRAGEGAPFTGLKPAGAVEPAVAEADKALVGGSADALVKLVSDDVAAGIRKRYEHAAETYRHKDESVAQGREFVKAYVEFTHYVERLHTDATGAGAHGEHGGDPHAEQHGGAGHSPVGHGAAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q14</accession>
    <name>Q39Q14_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3451"/>
    <dbReference type="EnsemblBacteria" id="ABB33660">
        <property type="protein sequence ID" value="ABB33660"/>
        <property type="gene ID" value="Gmet_3451"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3451"/>
    <dbReference type="HOGENOM" id="CLU_2522817_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="84" mass="9362" checksum="E6A0ADA4305950B6" modified="2005-11-22" version="1">MIPANLSNIFFILANRMNLSAIQESGTVQCRLKSPEKSDFFIIRQAAPQNHWTQKAAVGEPAENSFGVVAREWHSKFAPFSPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q29</accession>
    <name>Q39Q29_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminotransferase</fullName>
            <ecNumber evidence="1">2.6.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514661.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3433"/>
    <dbReference type="EnsemblBacteria" id="ABB33645">
        <property type="protein sequence ID" value="ABB33645"/>
        <property type="gene ID" value="Gmet_3433"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3433"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_1_7"/>
    <dbReference type="OMA" id="YFNHEMA"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901605">
        <property type="term" value="P:alpha-amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="2">
        <location>
            <begin position="34"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="391" mass="42988" checksum="447F77FD21C09AC2" modified="2005-11-22" version="1">MKFAISDQIRSVHAPPITEVKGWLASREPDPGRHLIDLCQAVPDYAPARQLTDYLATCLDDPAMAKYSPDEGLLEVREGVCARYGRVYGAAPAPEGVCLTIGASQAFWLAMVTLCRAGDEVIVPLPAYFDHPMALEMLGLRPVWLPFDEKRGGVVDPAAVERLITPRTRAILLVTPSNPTGVVTPPDVIHELYSLARRRGTALVIDETYADFIPGGAAPHDLFADPHWGDHLVQIMSFGKTYALTGYRAGCLVASDAFISHALKAQDTMAVCQPRITQHAVLYGVRHLDDWVAENRLMMERRHDLFRSVFTRPGNPFELAASGTFFAWVRHPFPGKTGREAARRLAVEAGVICLPGEVFGPGLEPYLRLAFGNIREEAIPEAVERFRGLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QE9</accession>
    <name>Q39QE9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type VI secretion system needle hub protein TssE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tssE</name>
        <name evidence="2" type="ordered locus">Gmet_3312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512536.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3312"/>
    <dbReference type="EnsemblBacteria" id="ABB33525">
        <property type="protein sequence ID" value="ABB33525"/>
        <property type="gene ID" value="Gmet_3312"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3312"/>
    <dbReference type="eggNOG" id="COG3518">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132637_2_0_7"/>
    <dbReference type="OMA" id="PMEMSFQ"/>
    <dbReference type="OrthoDB" id="1918415at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007048">
        <property type="entry name" value="IraD/Gp25-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017737">
        <property type="entry name" value="TssE1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04965">
        <property type="entry name" value="GPW_gp25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03357">
        <property type="entry name" value="VI_zyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GPW_gp25" evidence="1">
        <location>
            <begin position="28"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="136" mass="15631" checksum="92CEF089AC9E2D4D" modified="2005-11-22" version="1">MRDERLLERIRSFERDPARRGRPDHGRLVESVLAHLRQILNTRQGSAPIAPDYGVPDFLDFLQTYPDSVREIERSIRVAIQTYEPRLDGVRVAFIPQEDDVLALRFQITARITDDDGGTVRFETVVDTDGKIAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QF3</accession>
    <name>Q39QF3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma-54-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_3308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512532.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3308"/>
    <dbReference type="EnsemblBacteria" id="ABB33521">
        <property type="protein sequence ID" value="ABB33521"/>
        <property type="gene ID" value="Gmet_3308"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3308"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_8_1_7"/>
    <dbReference type="OMA" id="SPVHEKF"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="PAS" evidence="6">
        <location>
            <begin position="103"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="5">
        <location>
            <begin position="243"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="548" mass="61013" checksum="485A6425BA4FD48E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QG2</accession>
    <name>Q39QG2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512523.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3299"/>
    <dbReference type="EnsemblBacteria" id="ABB33512">
        <property type="protein sequence ID" value="ABB33512"/>
        <property type="gene ID" value="Gmet_3299"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3299"/>
    <dbReference type="eggNOG" id="ENOG50338CY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_651747_0_0_7"/>
    <dbReference type="OMA" id="NESANMR"/>
    <dbReference type="OrthoDB" id="837523at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004222984" evidence="1">
        <location>
            <begin position="22"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="448" mass="47143" checksum="3364BBC1CA44E510" modified="2005-11-22" version="1">MIKKTSVSVAAVMMLAAPALAQEVPQATTPAYNCDFEPSCEVAPGIYGKMASPVTSKFNLSIGGFVKLDYAYNSVNLGSNGALGTLQNGIPKSSSAAGRQDQSIFTARQSRFWLKVAGPNFLGAKTNAIIEADFYGGGGSSNESPNMRLRLANTTLDWVNTQVLVGQAYDIFGPAISSTVDFGSGNKTGAPNNPRVPQVRVTQKVNLNSDNALRLVLGVQNPVQDANAQTGTNSDSWGGKLNVAGQAMLISKALGVAPGYYGLSMNSLTAGVFGLYGNQSVGDNSKTVDTWGYGFYTFVPLLSSKDGRNRAMTASFEGQLYMAANQSVNGATAGTVIGPAGSKTAAKGYGFYGQLIFYPTQDLGITAGYGRRNAYNYASYSGINNFEKSNSNIYANIAYDLNAAVRVAVEYQNLNTQYGNVTNGTGNLAGLATSGTANIARFAAFYFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QH3</accession>
    <name>Q39QH3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sodium/solute symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">aplB</name>
        <name evidence="9" type="ordered locus">Gmet_3288</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512511.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3288"/>
    <dbReference type="EnsemblBacteria" id="ABB33501">
        <property type="protein sequence ID" value="ABB33501"/>
        <property type="gene ID" value="Gmet_3288"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3288"/>
    <dbReference type="eggNOG" id="COG4147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_8_3_7"/>
    <dbReference type="OMA" id="FACANML"/>
    <dbReference type="OrthoDB" id="278483at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00813">
        <property type="entry name" value="sss"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223148" evidence="8">
        <location>
            <begin position="21"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="609"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="655" mass="68274" checksum="7F15C163CFFAFF91" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QK8</accession>
    <name>Q39QK8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Methylmalonyl-CoA epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">mceE</name>
        <name evidence="3" type="ordered locus">Gmet_3253</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methylmalonyl-CoA epimerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512691.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3253"/>
    <dbReference type="EnsemblBacteria" id="ABB33466">
        <property type="protein sequence ID" value="ABB33466"/>
        <property type="gene ID" value="Gmet_3253"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3253"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_5_2_7"/>
    <dbReference type="OMA" id="IHHICYE"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03081">
        <property type="entry name" value="metmalonyl_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="134" mass="14555" checksum="CB7F14B61002F033" modified="2005-11-22" version="1">MLTKINHIGIAVQSLADAVPFYRDNLGMAFMGTEEVPEQKVTVAFFQIGESKIELLEPTSDDSPVAKFIEKNGAGIHHIAYEVEDIEAAIARLVADGARMIDSVPRNGAHGARIAFIHPKTSRGVLTELCQMGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QN9</accession>
    <name>Q39QN9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfite reductase, assimilatory</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_3222</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512661.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3222"/>
    <dbReference type="EnsemblBacteria" id="ABB33435">
        <property type="protein sequence ID" value="ABB33435"/>
        <property type="gene ID" value="Gmet_3222"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3222"/>
    <dbReference type="eggNOG" id="COG1251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072599_0_0_7"/>
    <dbReference type="OMA" id="TTFCKRG"/>
    <dbReference type="OrthoDB" id="1128731at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045169">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017220">
        <property type="entry name" value="Sulphite_reductase_assimil"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11493">
        <property type="entry name" value="PTHR11493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037487">
        <property type="entry name" value="Sulfite_red_assimil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="SSF55124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NIR_SIR_ferr" evidence="7">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="NIR_SIR" evidence="6">
        <location>
            <begin position="86"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="221" mass="24039" checksum="CE9EB92B96841371" modified="2005-11-22" version="1">MKKDILEKGAIVQRDRETYAIAPHIPGGITDTATLRKICDVADRYGVKELKLTSAQRIALMGVKEEDLDTIWSDLDQQPGAAIGLCVRSVKICPGTTWCKRGVQDSVALGLKIDTIYHAMKLPNKMKMGISGCMVNCAETLLKDIGVVGTPKGWRIYVGGNAGARPRIGEVFTDTAPDDDEVLAVVARIVDYYKGSGSEQRLGRIVEQMGIETFRQAVLGT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QR1</accession>
    <name>NADD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable nicotinate-nucleotide adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Deamido-NAD(+) diphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Deamido-NAD(+) pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Nicotinate mononucleotide adenylyltransferase</fullName>
            <shortName evidence="1">NaMN adenylyltransferase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nadD</name>
        <name type="ordered locus">Gmet_3200</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H(+) + nicotinate beta-D-ribonucleotide = deamido-NAD(+) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22860"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58437"/>
            <dbReference type="EC" id="2.7.7.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; deamido-NAD(+) from nicotinate D-ribonucleotide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NadD family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.18" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512638.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QR1"/>
    <dbReference type="SMR" id="Q39QR1"/>
    <dbReference type="STRING" id="269799.Gmet_3200"/>
    <dbReference type="EnsemblBacteria" id="ABB33413">
        <property type="protein sequence ID" value="ABB33413"/>
        <property type="gene ID" value="Gmet_3200"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3200"/>
    <dbReference type="eggNOG" id="COG1057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069765_0_1_7"/>
    <dbReference type="OMA" id="IHIGHLI"/>
    <dbReference type="OrthoDB" id="1433958at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00332"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004515">
        <property type="term" value="F:nicotinate-nucleotide adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02165">
        <property type="entry name" value="NMNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00244">
        <property type="entry name" value="NaMN_adenylyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005248">
        <property type="entry name" value="NadD/NMNAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00482">
        <property type="entry name" value="TIGR00482"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000078382" description="Probable nicotinate-nucleotide adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00244"/>
        </source>
    </evidence>
    <sequence length="216" mass="24300" checksum="7938269E24F84327" modified="2005-11-22" version="1">MRTGILGGTFNPIHHAHLRIAEEVRDAFALDQVIFIPAASPPHKPMEGEIPFEVRCEMVRLATADNPSFAVSDLEGRRTGKSYSIDTLRELRRERPGDEFFFIIGSDSFLDFGSWHEYEAIFSSCNIVAVERPGAVIRDLAAAIPVAVAPQFCYHAAEKRLAHRSGYSVYYLAGIPLDISSSAIRRLARLGRSIRYLVPEPVAHYITEQRIYTHDR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QR3</accession>
    <name>PROB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate 5-kinase</fullName>
            <ecNumber evidence="1">2.7.2.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Gamma-glutamyl kinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">proB</name>
        <name type="ordered locus">Gmet_3198</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-glutamate = ADP + L-glutamyl 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14877"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutamate 5-kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512636.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QR3"/>
    <dbReference type="SMR" id="Q39QR3"/>
    <dbReference type="STRING" id="269799.Gmet_3198"/>
    <dbReference type="PRIDE" id="Q39QR3"/>
    <dbReference type="EnsemblBacteria" id="ABB33411">
        <property type="protein sequence ID" value="ABB33411"/>
        <property type="gene ID" value="Gmet_3198"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3198"/>
    <dbReference type="eggNOG" id="COG0263">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025400_2_0_7"/>
    <dbReference type="OMA" id="TVIHRDN"/>
    <dbReference type="OrthoDB" id="1480250at2"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00359"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0641">Proline biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000230046" description="Glutamate 5-kinase">
        <location>
            <begin position="1"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="1">
        <location>
            <begin position="281"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="174"/>
            <end position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="216"/>
            <end position="222"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00456"/>
        </source>
    </evidence>
    <sequence length="373" mass="40358" checksum="F9B4E9117C0761B3" modified="2005-11-22" version="1">MRTAILKKVKRIVIKIGSRVLTGDENGLNHAFIARLAAETASLRQQGRQVIVVSSGAVAAGRRELGIEGRPKSIPQKQAAAAIGQSRLMRAYEEDFGRFGHKVAQILLTRDDLANRRRFLNARATLDTLLDFGVIPVINENDTVVVDEIKFGDNDNLSALVTNLAEAHLLVILTDIDGFYDSDPRANPDARLIHLVKSITRETERAAGDSGSSVGTGGMVTKLAAAKKAGQFGVPTLMLNGTVPGILTKAFAGREVGTLFLPARESLNRRKHWIAHTLRPSGRVIVDDGARTVLSRQGKSLLPSGVIRVEGEFDRGACVRVCGADGAEIARGVVDYSHAEIERILGHRSGEIEAILGYKYGDEIIHRDNLVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QS7</accession>
    <name>Q39QS7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3184</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33397.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366158.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3184"/>
    <dbReference type="EnsemblBacteria" id="ABB33397">
        <property type="protein sequence ID" value="ABB33397"/>
        <property type="gene ID" value="Gmet_3184"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3184"/>
    <dbReference type="eggNOG" id="ENOG5033MMY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138593_0_1_7"/>
    <dbReference type="OMA" id="DLLWHYF"/>
    <dbReference type="OrthoDB" id="1870180at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020483">
        <property type="entry name" value="Uncharacterised_YgbA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11756">
        <property type="entry name" value="YgbA_NO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33397.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="118" mass="13904" checksum="8511FC9BD28B0521" modified="2012-10-31" version="2">METFSNKQLKDVKVLVDFVRVYCHACHDRSLRAPFDLPPELQRRYSRGVELCPECAALLAHGIQKRRKCPLDPKPSCKSCRIHCYSKEYRAKIREVMGFSGKRMIMRGRLDYLLHFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QU8</accession>
    <name>Q39QU8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Radical SAM domain iron-sulfur cluster-binding oxidoreductase, TIGR01212 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">yhcC-1</name>
        <name evidence="8" type="ordered locus">Gmet_3163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513879.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3163"/>
    <dbReference type="DNASU" id="3741132"/>
    <dbReference type="EnsemblBacteria" id="ABB33376">
        <property type="protein sequence ID" value="ABB33376"/>
        <property type="gene ID" value="Gmet_3163"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3163"/>
    <dbReference type="eggNOG" id="COG1242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060920_0_0_7"/>
    <dbReference type="OMA" id="NAGFTCP"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005911">
        <property type="entry name" value="YhcC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="PTHR11135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF1">
        <property type="entry name" value="PTHR11135:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01091">
        <property type="entry name" value="uncharacterized_CHP01210-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01212">
        <property type="entry name" value="TIGR01212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="14"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="310" mass="34612" checksum="E87E689BAFF473A8" modified="2005-11-22" version="1">MTERRYTAFSDELRHIFGCRVQRISVDAGFTCPNRDGAVGTGGCIFCGGKGSGSFGIRPELSVTRQLLHGKEFLARRYGAAKFLAYFQAYSNTYAPVERLRLLYEEALAVSDVAGLIVGTRPDCLPSEVLDLLAGYARRTYFWLELGLQSPLDRTLALINRGHDFAAFADAVVWSRERGIRVCAHVILGLPGESREEMLATAEILNGLGVEGVKLHQLHVMKGTVLEEMYRRGEVRCLERDAYVDIVCDFLERLDPRIVIHRLVGDAPADHLVAPDWSLRKGEVLDAVDAELTRRVTRQGSVMRDRGRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QW4</accession>
    <name>Q39QW4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin and coenzyme A sequestration protein dodecin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3147</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513863.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3147"/>
    <dbReference type="EnsemblBacteria" id="ABB33360">
        <property type="protein sequence ID" value="ABB33360"/>
        <property type="gene ID" value="Gmet_3147"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3147"/>
    <dbReference type="eggNOG" id="COG3360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161196_1_1_7"/>
    <dbReference type="OMA" id="HYQVGLK"/>
    <dbReference type="OrthoDB" id="2025589at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009923">
        <property type="entry name" value="Dodecin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025543">
        <property type="entry name" value="Dodecin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036694">
        <property type="entry name" value="Dodecin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39324">
        <property type="entry name" value="PTHR39324"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07311">
        <property type="entry name" value="Dodecin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89807">
        <property type="entry name" value="SSF89807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="73" mass="8165" checksum="E66F7CCE82C9373D" modified="2005-11-22" version="1">MSYGDDRIYKKVEIIGVSKRGLEAAIQAAVAKAHKSLDKLSWFEVQDIRGHVGDDGMIAEYQVVLKVAFEIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R56</accession>
    <name>Q39R56_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3053"/>
    <dbReference type="EnsemblBacteria" id="ABB33268">
        <property type="protein sequence ID" value="ABB33268"/>
        <property type="gene ID" value="Gmet_3053"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3053"/>
    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046484_7_0_7"/>
    <dbReference type="OMA" id="WAFREYL"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002071">
        <property type="entry name" value="Thermonucl_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01123">
        <property type="entry name" value="TNASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TNase-like" evidence="2">
        <location>
            <begin position="27"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="180" mass="20774" checksum="5D86538FAE10D7B4" modified="2005-11-22" version="1">MMKRICGVVLLWIILISLPVWAKEPLRIIEGEVVKVVDGDTITIDSEGTRVKVRLYGIDAPETEKINRKTGVVTKPGQPFGEEAFHALADKVSNKSVRLEVMGIDKYRRSVSFVWLGDRNINREMVREGWSWAFRKYLDRFSAYFLDDEDIARSEKRGIWQDADPEPPWEFRKRTKTSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R97</accession>
    <name>Q39R97_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zinc metalloendopeptidase, M23 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3012</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514325.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3012"/>
    <dbReference type="EnsemblBacteria" id="ABB33227">
        <property type="protein sequence ID" value="ABB33227"/>
        <property type="gene ID" value="Gmet_3012"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3012"/>
    <dbReference type="eggNOG" id="COG0739">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120941_0_0_7"/>
    <dbReference type="OMA" id="VTSGIGW"/>
    <dbReference type="OrthoDB" id="1891666at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011055">
        <property type="entry name" value="Dup_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016047">
        <property type="entry name" value="Peptidase_M23"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01551">
        <property type="entry name" value="Peptidase_M23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51261">
        <property type="entry name" value="SSF51261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223182" evidence="2">
        <location>
            <begin position="19"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M23" evidence="3">
        <location>
            <begin position="49"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="199" mass="21215" checksum="DB2888EA6DC8A19D" modified="2005-11-22" version="1">MKLIISAILFLLLLPAFAAASRQLPVDGGTVTSGIGWRLDPFGSGRMTYHQGVDIAVPEGTPVYPTQRGTVTFAGPYKGYGNLVAVDHGNGYVTLYGHNSTIRVTPGQAVDTKTVLALAGSTGRSTGPHVHYEVRQIPGYDKKARERLEEQLKALVAEKVNGWVEEYVAKGEGDEGGNPEEPRQHPLAGLALPGGEELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RA4</accession>
    <name>Q39RA4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514317.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3005"/>
    <dbReference type="EnsemblBacteria" id="ABB33220">
        <property type="protein sequence ID" value="ABB33220"/>
        <property type="gene ID" value="Gmet_3005"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3005"/>
    <dbReference type="HOGENOM" id="CLU_1765412_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="16552" checksum="5773F22C1571DC0A" modified="2005-11-22" version="1">MGLLKKIAIFLPLWLVLAGVFAVFIAFTWSNWPQYYQLSQAPVATKATIVGIDNTTPKKLEIYSYTVGNQLYRRTWRVCGGAVGDVITIYYDARNPALSFPTHPDELLKKEYKGLLISGFWFSTFISIILTGLIGEWLSKGKTSTFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RH3</accession>
    <name>Q39RH3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamin biosynthesis sulfur carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiS-1</name>
        <name evidence="1" type="ordered locus">Gmet_2933</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33151.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512869.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2933"/>
    <dbReference type="DNASU" id="3740827"/>
    <dbReference type="EnsemblBacteria" id="ABB33151">
        <property type="protein sequence ID" value="ABB33151"/>
        <property type="gene ID" value="Gmet_2933"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2933"/>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174611_3_0_7"/>
    <dbReference type="OMA" id="HFLPMNI"/>
    <dbReference type="OrthoDB" id="2084255at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34472">
        <property type="entry name" value="PTHR34472"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33151.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="65" mass="7188" checksum="C0D0DFB746DA5185" modified="2012-10-31" version="2">MEIIVNGEARAATPMSMLELLRSLDIDPRRVAVELNHDILPKGEYESTILNDGDRIEIVHFVGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RK6</accession>
    <name>Q39RK6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heme exporter protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_2900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CcmC/CycZ/HelC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512836.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2900"/>
    <dbReference type="EnsemblBacteria" id="ABB33118">
        <property type="protein sequence ID" value="ABB33118"/>
        <property type="gene ID" value="Gmet_2900"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2900"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049710_2_2_7"/>
    <dbReference type="OMA" id="WLVMHVS"/>
    <dbReference type="OrthoDB" id="955123at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015232">
        <property type="term" value="F:heme transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003557">
        <property type="entry name" value="Cyt_c_biogenesis_CcmC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017562">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01386">
        <property type="entry name" value="CCMCBIOGNSIS"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03144">
        <property type="entry name" value="cytochr_II_ccsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="252"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="10">
        <location>
            <begin position="68"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="284" mass="31016" checksum="7CA6F14A60C7C420" modified="2005-11-22" version="1">MTSSMLFNIATFSYLISMLAFFTFLAVKGKSVGLVGSLAAYFGFIVHSAAILLRWKESYDIGMGHAPLSNLYESVVFFAWTIILIFGIIDLKYKYRVVGAFVVPFALLGMAWAQLGMDSGIQPLVPALQSNWLLYHVITCFLGYAAFAVACGISIMYLIKAGKDESAGSAQSGGIIAMFPSIKILDDLNYKAIIIGFPLLTLGIITGAAWANYAWGTYWSWDPKETWSLIVWFIYAAFLHARFTRGWVGKKAAILSIVGFAATIFCYLGVNLFLSGLHSYGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RL7</accession>
    <name>Q39RL7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix transcriptional regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2889</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512825.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2889"/>
    <dbReference type="EnsemblBacteria" id="ABB33107">
        <property type="protein sequence ID" value="ABB33107"/>
        <property type="gene ID" value="Gmet_2889"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2889"/>
    <dbReference type="eggNOG" id="COG1497">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_098264_0_0_7"/>
    <dbReference type="OMA" id="YTVARQD"/>
    <dbReference type="OrthoDB" id="1291710at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="202" mass="22564" checksum="1EE9C467E3492804" modified="2005-11-22" version="1">MNDKTDKALDSYRSFLLLSEIAGEEPLSQRELSRRAGIAVGLVNSYLKNLVAKGYVRVKNFPRNRYAYLLTPTGIAEKSRLAYQHLSYFTNLYTVARQDYLALFQSLKAEGVTEVVFCGVDEVAEIAYLSLREAGLELVAVLDDQGHGNSFFGVRVMPLIVWEQRGNEPIVVTSLKRGDELIEGLKKAGVNGWRFIVAPRGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RP6</accession>
    <name>Q39RP6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfate adenylyltransferase subunit 1</fullName>
            <ecNumber evidence="6">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-sulfurylase large subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Sulfate adenylate transferase</fullName>
            <shortName evidence="6">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 8" type="primary">cysN</name>
        <name evidence="8" type="ordered locus">Gmet_2860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">With CysD forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer composed of CysD, the smaller subunit, and CysN.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514556.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2860"/>
    <dbReference type="EnsemblBacteria" id="ABB33078">
        <property type="protein sequence ID" value="ABB33078"/>
        <property type="gene ID" value="Gmet_2860"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2860"/>
    <dbReference type="eggNOG" id="COG2895">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007265_5_2_7"/>
    <dbReference type="OMA" id="PGHVEYT"/>
    <dbReference type="OrthoDB" id="244339at2"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04166">
        <property type="entry name" value="CysN_ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03695">
        <property type="entry name" value="CysN_NodQ_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04095">
        <property type="entry name" value="CysN_NoDQ_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00062">
        <property type="entry name" value="Sulf_adenylyltr_sub1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041757">
        <property type="entry name" value="CysN_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044138">
        <property type="entry name" value="CysN_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044139">
        <property type="entry name" value="CysN_NoDQ_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011779">
        <property type="entry name" value="SO4_adenylTrfase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="SSF50465"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02034">
        <property type="entry name" value="CysN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 6 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="22"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="31"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="110"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="165"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="555" mass="61136" checksum="B594837D268F372E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RT6</accession>
    <name>Q39RT6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Squalene cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">shc-1</name>
        <name evidence="6" type="ordered locus">Gmet_2820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis; hopanoid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513984.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2820"/>
    <dbReference type="EnsemblBacteria" id="ABB33038">
        <property type="protein sequence ID" value="ABB33038"/>
        <property type="gene ID" value="Gmet_2820"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2820"/>
    <dbReference type="eggNOG" id="COG1657">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019345_0_0_7"/>
    <dbReference type="OMA" id="LIGEWPW"/>
    <dbReference type="OrthoDB" id="260889at2"/>
    <dbReference type="UniPathway" id="UPA00337"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016866">
        <property type="term" value="F:intramolecular transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016104">
        <property type="term" value="P:triterpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02892">
        <property type="entry name" value="SQCY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006400">
        <property type="entry name" value="Hopene-cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032696">
        <property type="entry name" value="SQ_cyclase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032697">
        <property type="entry name" value="SQ_cyclase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018333">
        <property type="entry name" value="Squalene_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11764">
        <property type="entry name" value="PTHR11764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13243">
        <property type="entry name" value="SQHop_cyclase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13249">
        <property type="entry name" value="SQHop_cyclase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01016">
        <property type="entry name" value="Prenyltransferase_Like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="SSF48239"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01507">
        <property type="entry name" value="hopene_cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01787">
        <property type="entry name" value="squalene_cyclas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="SQHop_cyclase_N" evidence="5">
        <location>
            <begin position="57"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="SQHop_cyclase_C" evidence="4">
        <location>
            <begin position="355"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="679" mass="76370" checksum="E6C6AB3EE64A6116" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RU2</accession>
    <name>Q39RU2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2814</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2814"/>
    <dbReference type="EnsemblBacteria" id="ABB33032">
        <property type="protein sequence ID" value="ABB33032"/>
        <property type="gene ID" value="Gmet_2814"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2814"/>
    <dbReference type="eggNOG" id="COG0546">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045011_11_3_7"/>
    <dbReference type="OMA" id="CALYCPE"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="202" mass="21980" checksum="7AD6A237AE1FE4B7" modified="2005-11-22" version="1">MASIAEIMARPHWVFDLDGTLTVPVHDFAAIRADLGIPDGTDILGHIESLPEEEARRLHQRLDEIEECLAARAEPAAGAVRLVETLHRRGKSLGIVTRNTREIALRVLETIGVGGRFAPDDVLGRHDAQPKPDPHGLAILSTRWGATGRSMVMVGDYLFDLQSGRASGAATVHVDRSGNFRWPELTDIAVESLDELAELLGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="43" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RW1</accession>
    <name>Q39RW1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2795</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366101.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2795"/>
    <dbReference type="EnsemblBacteria" id="ABB33013">
        <property type="protein sequence ID" value="ABB33013"/>
        <property type="gene ID" value="Gmet_2795"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2795"/>
    <dbReference type="HOGENOM" id="CLU_2507994_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="85" mass="9247" checksum="23C870CC3D2EEF63" modified="2005-11-22" version="1">MINAGQGTKNFIIGPLRRIDSKGAVKEFNPPREDVTTLTCNIAKEILTWVRKLLADKGANIPEPEEADLTLAVDAALAIMADSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RW5</accession>
    <name>Q39RW5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2791</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511671.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2791"/>
    <dbReference type="EnsemblBacteria" id="ABB33009">
        <property type="protein sequence ID" value="ABB33009"/>
        <property type="gene ID" value="Gmet_2791"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2791"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052868_1_1_7"/>
    <dbReference type="OMA" id="RGSYVGC"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026669">
        <property type="entry name" value="Arsenite_MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43675">
        <property type="entry name" value="PTHR43675"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="84"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="266" mass="27818" checksum="C7A4E8F790E0801C" modified="2005-11-22" version="1">MDKQRNEEIRGAVRENYGKVAVSGGAGCGCSSSSCCGTPNGATTEDISLGLGYSGEDVAAVPEGANLGLGCGNPQAIASLQLGETVLDLGSGGGFDCFLAARAVGHTGHVIGVDMTPEMITKSRRNADKANFGNVDFRLGELENLPVADGIVDVIISNCVINLSPEKAKVFSESFRVLKSGGRLAISDVVATAEMPGDIKNNMAFHTGCIAGASSIEEIESMLERTGFVNIRINPKTESRAFIRDWMPGSKIEDYVVSATIEAIKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S10</accession>
    <name>Q39S10_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endopeptidase La</fullName>
            <ecNumber evidence="1">3.4.21.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins in presence of ATP.</text>
            <dbReference type="EC" id="3.4.21.53"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S16 family.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.53" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511713.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2746"/>
    <dbReference type="EnsemblBacteria" id="ABB32964">
        <property type="protein sequence ID" value="ABB32964"/>
        <property type="gene ID" value="Gmet_2746"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2746"/>
    <dbReference type="eggNOG" id="COG1067">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014785_0_1_7"/>
    <dbReference type="OMA" id="DWVYVNN"/>
    <dbReference type="OrthoDB" id="128102at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041699">
        <property type="entry name" value="AAA_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008269">
        <property type="entry name" value="Lon_proteolytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027065">
        <property type="entry name" value="Lon_Prtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10046">
        <property type="entry name" value="PTHR10046"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13654">
        <property type="entry name" value="AAA_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05362">
        <property type="entry name" value="Lon_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51786">
        <property type="entry name" value="LON_PROTEOLYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Lon proteolytic" evidence="3">
        <location>
            <begin position="568"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="137"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="211"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="658"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="811" mass="90739" checksum="0E627134156EBA4A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S55</accession>
    <name>Q39S55_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">Phosphate-binding protein PstS</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pstS</name>
        <name evidence="9" type="ordered locus">Gmet_2701</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Part of the ABC transporter complex PstSACB involved in phosphate import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the PstS family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511760.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2701"/>
    <dbReference type="EnsemblBacteria" id="ABB32919">
        <property type="protein sequence ID" value="ABB32919"/>
        <property type="gene ID" value="Gmet_2701"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2701"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034528_1_1_7"/>
    <dbReference type="OMA" id="FPYPVYA"/>
    <dbReference type="OrthoDB" id="1222928at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042301">
        <property type="term" value="F:phosphate ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005673">
        <property type="entry name" value="ABC_phos-bd_PstS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002756">
        <property type="entry name" value="PstS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00975">
        <property type="entry name" value="3a0107s03"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223215" description="Phosphate-binding protein PstS" evidence="7">
        <location>
            <begin position="27"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="8">
        <location>
            <begin position="21"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="342" mass="36496" checksum="A5B04EDBCC30CE64" modified="2005-11-22" version="1">MLKALRKSLAILATLAVTAAAGQAGAETLINGAGATFPYPLYSKWFSEYAKIDPSVKFNYQSIGSGGGIKQITAQTVDFGASDKFLSDAELKAAPGKLLHIPTVMGAVVVTYNLPGAPKGLKLKAEDVADIFLGKISKWNDPRIADDNPGVKLPNSPIIVVHRSDGSGTTSIFTDFLSGVNQEWAKKVGKGASVKWPIGLGGKGNEGVAGQIKTTANSIGYVELAYAFENKLPYATLKNKSGSWVVPSIQTTSAAAAAAVKHMPADYRISLVNQPGKDAYPIVGFTWLLVYEKQKDAVKGKKLVEFLNWSLRNGQKMAAPLLYAPLPENVKKMVEKTIKTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S95</accession>
    <name>Q39S95_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2661</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511800.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2661"/>
    <dbReference type="DNASU" id="3740181"/>
    <dbReference type="EnsemblBacteria" id="ABB32879">
        <property type="protein sequence ID" value="ABB32879"/>
        <property type="gene ID" value="Gmet_2661"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2661"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000134_18_0_7"/>
    <dbReference type="OMA" id="EFADSSH"/>
    <dbReference type="OrthoDB" id="1360387at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223327" evidence="2">
        <location>
            <begin position="29"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="94"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="127"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="160"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="226"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="287" mass="30770" checksum="DF3A57B686808A2D" modified="2005-11-22" version="1">MTIAATMLRAITVLMALLLLVAAGPAAAADEGGDLLEQFLGRKYEPVLKPLEIPEGTPPSEALFLYLNQGYGDAGVIGDFLAKGADANYADKEYRITLLHNVAHYGHAEATRILLAAGARVNAVNGEGNTPLFAAVHEGHDDVARILLDAGADVTIANSYWYTPLREACRRGNTGMVRLLLEKGADVNITDNKGFTPLHAAVSAEALEAATLILDSGADINIAGRYGDTPLHYAVGLGYEEFVRLFLARGADPTIRNDRGLTPRQLAEERGFASIVELFRNWGKNTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SD2</accession>
    <name>Q39SD2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhnB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511837.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2623"/>
    <dbReference type="EnsemblBacteria" id="ABB32842">
        <property type="protein sequence ID" value="ABB32842"/>
        <property type="gene ID" value="Gmet_2623"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2623"/>
    <dbReference type="eggNOG" id="COG2764">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_11_2_7"/>
    <dbReference type="OMA" id="YKQAFGA"/>
    <dbReference type="OrthoDB" id="1467120at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="8"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="164" mass="18136" checksum="1BAE95EF0C963FAA" modified="2005-11-22" version="1">MTKAIPEGYQTVTPMFMFKDARKAMEFYKRAFGAEERYVMPGPDGKGVMHAELRIGNSIVMMGEEHPQEACKSAETMGGSPVSFYIYLENVDEAFGRALAAGAKTTMPVDDMFWGDRAGTVQDPFGYSWTLATHTKDLTPQEIQQGAQAFFARMNRPGGTAERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SE9</accession>
    <name>Q39SE9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNA polymerase-binding protein Rnk</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rnk</name>
        <name evidence="3" type="ordered locus">Gmet_2606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511855.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2606"/>
    <dbReference type="EnsemblBacteria" id="ABB32825">
        <property type="protein sequence ID" value="ABB32825"/>
        <property type="gene ID" value="Gmet_2606"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2606"/>
    <dbReference type="eggNOG" id="COG0782">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120358_1_0_7"/>
    <dbReference type="OMA" id="VHCREES"/>
    <dbReference type="OrthoDB" id="1536415at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036953">
        <property type="entry name" value="GreA/GreB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029462">
        <property type="entry name" value="Rnk_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001437">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023459">
        <property type="entry name" value="Tscrpt_elong_fac_GreA/B_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30437">
        <property type="entry name" value="PTHR30437"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01272">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14760">
        <property type="entry name" value="Rnk_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006092">
        <property type="entry name" value="GreA_GreB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnk_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="GreA_GreB" evidence="1">
        <location>
            <begin position="57"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="142" mass="16165" checksum="66477CD5D2476088" modified="2005-11-22" version="1">MKRSAEERAIYITEFDQSRLEELLDQVNTEDSRDSKHLRELEDELLRAEVVEPQDIPADVITMNSRVCLKDLDSGEELHYTLVFPGDARLEDNRISILAPVGTALLGYRVGDTITWKVPGGTRRLKVKKILYQPEAAGDFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SF2</accession>
    <name>Q39SF2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">mRNA interferase</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Toxic component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PemK/MazF family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511858.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2603"/>
    <dbReference type="EnsemblBacteria" id="ABB32822">
        <property type="protein sequence ID" value="ABB32822"/>
        <property type="gene ID" value="Gmet_2603"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2603"/>
    <dbReference type="eggNOG" id="COG2337">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121823_1_1_7"/>
    <dbReference type="OMA" id="RREPEAC"/>
    <dbReference type="OrthoDB" id="1754531at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003477">
        <property type="entry name" value="PemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011067">
        <property type="entry name" value="Plasmid_toxin/cell-grow_inhib"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33988">
        <property type="entry name" value="PTHR33988"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02452">
        <property type="entry name" value="PemK_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033490">
        <property type="entry name" value="MazF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR033490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="121" mass="13233" checksum="71409C9442C56289" modified="2005-11-22" version="1">MFKRGGIYAVNLPHGDRREPEACPCLVVSNNISNEYSPVVTIIPLSFTHLEKIYDFETFLPAAGSGLEKDAKISSHILITIDKANVVGERLGFINKALMCQVNKALCLQLGIEEPPGHLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SI1</accession>
    <name>Q39SI1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513460.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32793">
        <property type="protein sequence ID" value="ABB32793"/>
        <property type="gene ID" value="Gmet_2574"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2574"/>
    <dbReference type="HOGENOM" id="CLU_1150565_0_0_7"/>
    <dbReference type="OMA" id="VECTQCT"/>
    <dbReference type="OrthoDB" id="1673999at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="246" mass="27122" checksum="2C7F741D1C9A50B4" modified="2005-11-22" version="1">MNGRTYKLVTGIISLFIALFLAWRIGLWLEPEPKQKNPAPVVPSPAAKEPPFVTGTVRKDLNFEVRNVRFGNRGKTVEGIGIVTFDSDRSDLKAAAVAMLKKLKEKVPAAERIVLTLKPSVDCPVCAMAEVTWDRGKVDMRYGIPSLEQMEEANTLIGTKDKKGETVDRPRLYLPDRETFAAGLAITQAIDAARKKNPSLGDDQLLEQAAAATGLNYAVARRSRDFMAAYYTATEYGEETFTLSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SM7</accession>
    <name>Q39SM7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514525.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2526"/>
    <dbReference type="EnsemblBacteria" id="ABB32747">
        <property type="protein sequence ID" value="ABB32747"/>
        <property type="gene ID" value="Gmet_2526"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2526"/>
    <dbReference type="eggNOG" id="COG1525">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046484_7_0_7"/>
    <dbReference type="OMA" id="SACSREK"/>
    <dbReference type="OrthoDB" id="1719840at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002071">
        <property type="entry name" value="Thermonucl_AS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="SSF50199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01123">
        <property type="entry name" value="TNASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223234" evidence="1">
        <location>
            <begin position="23"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="2">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="171" mass="19261" checksum="4C489B9E172333DF" modified="2005-11-22" version="1">MRIVTIILALAVFTAASSLSYASPSKTLEGTVAKVLDGDTLLLLSGARTVKVRLFGIDAPEVRRKLRPGQPFGSEAKQALEKKVAGKKVVVDVVDVDKNLLVIGVLTTEGRDIDREMIEEGWAWAYRQRLREPFTSRYVSAENKARKTRLGLWRQENPQPPWSFRFEQKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SM9</accession>
    <name>Q39SM9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2524</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514527.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2524"/>
    <dbReference type="EnsemblBacteria" id="ABB32745">
        <property type="protein sequence ID" value="ABB32745"/>
        <property type="gene ID" value="Gmet_2524"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2524"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_7"/>
    <dbReference type="OMA" id="DKMFLDN"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="326"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="363"/>
            <end position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="544" mass="60724" checksum="37DE4CA602DE6B03" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SQ2</accession>
    <name>Q39SQ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514647.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2499"/>
    <dbReference type="DNASU" id="3738985"/>
    <dbReference type="EnsemblBacteria" id="ABB32722">
        <property type="protein sequence ID" value="ABB32722"/>
        <property type="gene ID" value="Gmet_2499"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2499"/>
    <dbReference type="eggNOG" id="ENOG5032YDN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_162083_0_0_7"/>
    <dbReference type="OMA" id="PHIHVRY"/>
    <dbReference type="OrthoDB" id="1948244at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025427">
        <property type="entry name" value="DUF4160"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13711">
        <property type="entry name" value="DUF4160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="89" mass="10093" checksum="B53F01C04149FC57" modified="2005-11-22" version="1">MPAISMFYGIVIYLYFYDDERHKIPHIHAKYQGEDASVSIANGEILAGDIPLSKLRLVQAWIEIHRDALMADWALAVNGQPPFAIEPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SQ4</accession>
    <name>Q39SQ4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Anthranilate synthase component 1</fullName>
            <ecNumber evidence="5 11">4.1.3.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 14" type="primary">trpE</name>
        <name evidence="14" type="ordered locus">Gmet_2497</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>chorismate + L-glutamine = anthranilate + H(+) + L-glutamate + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterotetramer consisting of two non-identical subunits: a beta subunit (TrpG) and a large alpha subunit (TrpE).</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the anthranilate synthase component I family.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="5 11"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514649.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2497"/>
    <dbReference type="EnsemblBacteria" id="ABB32720">
        <property type="protein sequence ID" value="ABB32720"/>
        <property type="gene ID" value="Gmet_2497"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2497"/>
    <dbReference type="eggNOG" id="COG0147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006493_9_3_7"/>
    <dbReference type="OMA" id="GCVGYLD"/>
    <dbReference type="OrthoDB" id="1786019at2"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019999">
        <property type="entry name" value="Anth_synth_I-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005256">
        <property type="entry name" value="Anth_synth_I_PabB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11236">
        <property type="entry name" value="PTHR11236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00095">
        <property type="entry name" value="ANTSNTHASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="SSF56322"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00564">
        <property type="entry name" value="trpE_most"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Anth_synt_I_N" evidence="13">
        <location>
            <begin position="28"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate_bind" evidence="12">
        <location>
            <begin position="222"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="491" mass="53960" checksum="809771642EA328DA" modified="2005-11-22" version="1">MYFPDFETFRSLASQGNLIPVCREIMADMDTPVSAFRKIDDGSYSFLLESIEGGEKWGRYSFLGSNPATVIRTRGTTVEIVTNGETRAVTSDDPLGFVREYLSRFHPVEIPGLPRFFGGAVGYLGYDMVRHFERLPTEKPAVIGAWDSCFVITDTILIFDTMRQKITVVSNAHLEDGQAPEAAYAEAIARVDALIAKLRAPLPAMPATPAVRTVSFSSNVPRENFEAAVEKCKEYVRAGDIIQVVLSQRFSGALTVEPLAIYRVLRTLNPSPYMFFLRMDDTLVVGASPEVMVRKEGDRVELRPIAGTRPRGATPEEDQQLAEELLADPKERAEHVMLVDLGRNDLGRVCRTGTVKVSELMVIERYSHVMHIVSNVEGELVEGKDAFDVVRATFPAGTLSGAPKVRAMEIIDELEPVRREVYGGAVGYFSFSGNMDLAIAIRTLVIRDGMVHLQAGAGIVADSDPAAEYQETVNKAMAAVKAIETAEKGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SS6</accession>
    <name>Q39SS6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">dTDP-glucose 4,6-dehydratase</fullName>
            <ecNumber evidence="4 5">4.2.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rmlB</name>
        <name evidence="7" type="ordered locus">Gmet_2473</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>dTDP-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O</text>
            <dbReference type="Rhea" id="RHEA:17221"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="EC" id="4.2.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 5">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.46" evidence="4 5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512426.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2473"/>
    <dbReference type="EnsemblBacteria" id="ABB32698">
        <property type="protein sequence ID" value="ABB32698"/>
        <property type="gene ID" value="Gmet_2473"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2473"/>
    <dbReference type="eggNOG" id="COG1088">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_14_7"/>
    <dbReference type="OMA" id="KLIPLMC"/>
    <dbReference type="OrthoDB" id="707977at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01181">
        <property type="entry name" value="dTDP_gluc_dehyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="6">
        <location>
            <begin position="11"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="358" mass="40237" checksum="0CA0AAD4DA59BC53" modified="2005-11-22" version="1">MPEMFVPRAILVTGGAGFIGSNFITHFMAANPGCRVVNLDILTYAGNLKNLVGVEKNPDYRFVRGDICNGELVRELLAEERIEAVVHFAAESHVDRSITGPEIFVRTNVLGTQVLLEESRRHWEAKGVERFRFLHVSTDEVYGTLGETGYFTEETPLAPNSPYSASKAGSDLIVRAYYETYGFPALITRCSNNYGPYQFPEKLIPLMIHNIVANKPLPVYGDGRNVRDWLHVKDHSSAIETVLKGGKPGEVFNVGGNNEWFNIDIVQLLCDLLDERLGRPKGESRGLITFVKDRLGHDRRYAISAAKIKRELGWEPSYTFERGIAETVDWYLANGAWVEEVTSGAYRDYYEKQYGGES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SV2</accession>
    <name>Q39SV2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2447</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2447"/>
    <dbReference type="EnsemblBacteria" id="ABB32672">
        <property type="protein sequence ID" value="ABB32672"/>
        <property type="gene ID" value="Gmet_2447"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2447"/>
    <dbReference type="HOGENOM" id="CLU_164829_1_0_7"/>
    <dbReference type="OMA" id="ISSWADK"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="111" mass="12372" checksum="3DFF683783832BB7" modified="2005-11-22" version="1">MMSLQEPSKEAVEIDITVHIFTVSATLVGVCLTVISLLIISRKLSHVKSLGEDLLAFDALLFLSSCILSYSALRVRKKGRRHTLERTSEEVFFVALALMGIICVFIVYELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T93</accession>
    <name>Q39T93_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HEAT-like repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513314.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2306"/>
    <dbReference type="EnsemblBacteria" id="ABB32531">
        <property type="protein sequence ID" value="ABB32531"/>
        <property type="gene ID" value="Gmet_2306"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2306"/>
    <dbReference type="eggNOG" id="COG1413">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014447_0_0_7"/>
    <dbReference type="OMA" id="HDESWRV"/>
    <dbReference type="OrthoDB" id="772324at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03130">
        <property type="entry name" value="HEAT_PBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="SSF48371"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="666" mass="71614" checksum="939C3218AB4EC378" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TB3</accession>
    <name>Q39TB3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Negative regulator of flagellin synthesis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Anti-sigma-28 factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_2286</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514512.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2286"/>
    <dbReference type="EnsemblBacteria" id="ABB32511">
        <property type="protein sequence ID" value="ABB32511"/>
        <property type="gene ID" value="Gmet_2286"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2286"/>
    <dbReference type="eggNOG" id="COG2747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_169011_3_1_7"/>
    <dbReference type="OrthoDB" id="2074215at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035890">
        <property type="entry name" value="Anti-sigma-28_factor_FlgM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007412">
        <property type="entry name" value="FlgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031316">
        <property type="entry name" value="FlgM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04316">
        <property type="entry name" value="FlgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101498">
        <property type="entry name" value="SSF101498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03824">
        <property type="entry name" value="FlgM_jcvi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FlgM" evidence="9">
        <location>
            <begin position="39"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="101" mass="10831" checksum="7DB9419AC89F3E92" modified="2005-11-22" version="1">MKIDDKPILPATVATRSEAAAALADGDIHRSAAQGQGEDTVQLSGNAERVARMSEALQKIPDIRVERVQELKRQVAAGEYAVSARDVAEKMLMTMKKGVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TD1</accession>
    <name>Q39TD1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein-associated cytochrome b and CCG domain pair iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2267</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366023.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2267"/>
    <dbReference type="EnsemblBacteria" id="ABB32493">
        <property type="protein sequence ID" value="ABB32493"/>
        <property type="gene ID" value="Gmet_2267"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2267"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_7"/>
    <dbReference type="OMA" id="EMHRHKE"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="298"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="358"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="692" mass="76675" checksum="48F4A4D5A7F74ED4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TF4</accession>
    <name>Q39TF4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32470.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365997.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2243"/>
    <dbReference type="EnsemblBacteria" id="ABB32470">
        <property type="protein sequence ID" value="ABB32470"/>
        <property type="gene ID" value="Gmet_2243"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2243"/>
    <dbReference type="HOGENOM" id="CLU_1989448_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223259" evidence="1">
        <location>
            <begin position="25"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32470.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="125" mass="13535" checksum="5D1B890DE41FE587" modified="2012-10-31" version="2">MNRAKRLVTGLAIIVMAGLMTACASIQPEARAVVRDGGIAEQGDTVNLYYAHSKTAKEEFCPGAIVPVYRMGEGFYLIKTEVGKIRVVKELGDHYVQAVVTEGQIMSGDIATQPNSECLIQIPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TM6</accession>
    <name>Q39TM6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365927.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2169"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32398">
        <property type="protein sequence ID" value="ABB32398"/>
        <property type="gene ID" value="Gmet_2169"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2169"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_3_0_7"/>
    <dbReference type="OMA" id="YWKISEQ"/>
    <dbReference type="OrthoDB" id="694191at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015393">
        <property type="entry name" value="DUF1972"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09314">
        <property type="entry name" value="DUF1972"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DUF1972" evidence="1">
        <location>
            <begin position="4"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="395" mass="43691" checksum="F06A74C7859E3569" modified="2005-11-22" version="1">MRLAILGTRGIPARYGGFETFAEELALRLVARGTEVTVYCEANGTDQPREYRGIRLVHIPATACGPLTTVLFDLRCLWHARNSYDVVYMLGYGAAPFCLIPQVWGTDVWLNVDGIEWARGKWNSAAKLYFKMMEWLSTWVPDRIIADADGIRAHLESRHRLSSPCSVIPYGAPVAVVPPDASLLRKWNLEPGGYYLVVARIEPENHVREIIEGYRAHETQIPLVVVGNHMVTTDYARKLRPLAGSRVRLVGGVYDREELRALRYHARACFHGHSVGGTNPSLLEALGCGSLIIAHDNIFNREVVGDIGFYFSSSSTIPALLKGVESLTAPEKAALAGKARARIREKYDWGAIAEQYLDLIEMHCGERRGDVLLSGAIPAEKKAGISAGLGRRNLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TU4</accession>
    <name>Q39TU4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphoenolpyruvate synthase</fullName>
            <ecNumber evidence="5">2.7.9.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyruvate, water dikinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2101</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + pyruvate = AMP + 2 H(+) + phosphate + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:11364"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.9.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <dbReference type="EC" id="2.7.9.2" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513103.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2101"/>
    <dbReference type="EnsemblBacteria" id="ABB32330">
        <property type="protein sequence ID" value="ABB32330"/>
        <property type="gene ID" value="Gmet_2101"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2101"/>
    <dbReference type="eggNOG" id="COG0574">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_6_0_7"/>
    <dbReference type="OMA" id="QDTYLWV"/>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008986">
        <property type="term" value="F:pyruvate, water dikinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006319">
        <property type="entry name" value="PEP_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43030">
        <property type="entry name" value="PTHR43030"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPDK_N" evidence="8">
        <location>
            <begin position="41"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="382" mass="42022" checksum="F07F3EED950C08D1" modified="2005-11-22" version="1">MSTAVNMHDKRWGNKYGTVRSAGKVTPLVCWFEECRKDSVPLVGGKCSSLGELISAGVRVPPGFALTTEGYRRFMTDAGIDREIQSMVSGLDAGDMEALENTSGAIREMIEAHPFSAEIEDLVAERYRKLAVRSCLPAVPVAVRSSATAEDLPGASFAGQQDTYLWVRGADEVLHNMRRCISSLYTGRAIAYRINQGYADEQVAISVGVQKMANSFTAGVMFTLHPGNGDRSVIVIDSNYGFGESVVSGEVTPDNFVVNKITMDILERTISQKDIYYTVDQKTQVSRPIEVPFERQKVQSLMDDEITELAKMGKLIEKHYGRPMDIEWAVDKDLPFGGNIFILQARPETVWSQKQQPPGAAKGGASAMDYILASMLEGKRLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U55</accession>
    <name>Q39U55_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365897.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1990"/>
    <dbReference type="EnsemblBacteria" id="ABB32219">
        <property type="protein sequence ID" value="ABB32219"/>
        <property type="gene ID" value="Gmet_1990"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1990"/>
    <dbReference type="eggNOG" id="COG4105">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1592205_0_0_7"/>
    <dbReference type="OMA" id="HERKFAG"/>
    <dbReference type="OrthoDB" id="1967292at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="175" mass="19941" checksum="56BA1F47B96A05C9" modified="2005-11-22" version="1">MTSRTIIILMVTACLSGCTTVQKSLENQRLRTTQQDKLEQAVKLIERGNTEKAETLLEEVVAAQGVRGITDEALFRLALLSMPSDLNREDLANAVKYLERLQKEYPVSPWATQSSSLTDLLAVLPRHLQSTTELRRQIKSLRDLNLSLTRENKEMRLNIEKIKNLDLQLEKKVKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U80</accession>
    <name>Q39U80_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1965</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511879.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1965"/>
    <dbReference type="EnsemblBacteria" id="ABB32194">
        <property type="protein sequence ID" value="ABB32194"/>
        <property type="gene ID" value="Gmet_1965"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1965"/>
    <dbReference type="eggNOG" id="COG3868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_451831_0_0_7"/>
    <dbReference type="OrthoDB" id="1722608at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="SMART" id="SM00060">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fibronectin type-III" evidence="2">
        <location>
            <begin position="476"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="604" mass="65730" checksum="ADCEA4B55C00ADB5" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UA8</accession>
    <name>Q39UA8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1937</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511906.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1937"/>
    <dbReference type="DNASU" id="3738121"/>
    <dbReference type="EnsemblBacteria" id="ABB32166">
        <property type="protein sequence ID" value="ABB32166"/>
        <property type="gene ID" value="Gmet_1937"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1937"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082366_1_0_7"/>
    <dbReference type="OMA" id="DEDETPC"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005358">
        <property type="entry name" value="Puta_zinc/iron-chelating_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03692">
        <property type="entry name" value="CxxCxxCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="225" mass="26194" checksum="BCE28B960E9CCA92" modified="2005-11-22" version="1">MNEVLDEYRRLLSEVDHWFSRCIARSGEHIRCAEGCSECCRGLFDITLLDAALLKEGFDRLDAFTREQVLVKCRKRLAGLLRLWPEFAHPYMLNYRPEEEWELLMPDDDETPCPLLGADGRCLVYGFRPMTCRLHGLPLVDLTGEVLHDEWCTLNYVGGDPLADAGLRGEFTKIFREEVRLFRHFSERLLGQEFRELDTFIPTALLIDFTRFDWHRFAAGFSVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UB0</accession>
    <name>Q39UB0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Trans-isoprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511908.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1935"/>
    <dbReference type="EnsemblBacteria" id="ABB32164">
        <property type="protein sequence ID" value="ABB32164"/>
        <property type="gene ID" value="Gmet_1935"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1935"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_0_0_7"/>
    <dbReference type="OMA" id="CEGQALD"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="297" mass="31675" checksum="39CFD3FE8C57DFB4" modified="2005-11-22" version="1">MDLKNYLKERCAIVDEALERSLPGEGDLPVSVHRAMRYSVFAGGKRIRPVLMLAACEAVGGTPDLALPAACAMEMIHTYSLIHDDLPAMDDDDFRRGRPTNHKVFGEAIAILAGDALLTEAFILMSSPEYAAKAGHARILPVIHEIGICAGSRGMVGGQVVDMESEGKKDIDLATVQYIHTHKTGALMKASVKAGAILGGAEGDALAAMTRYGEAIGLAFQIADDILDIEGTTEQIGKDAGSDEARGKATYPAVMGLADSKRRAQELVDLALEALSPFGEKAEPLREIARYIVSRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UC5</accession>
    <name>Q39UC5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511923.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1920"/>
    <dbReference type="EnsemblBacteria" id="ABB32149">
        <property type="protein sequence ID" value="ABB32149"/>
        <property type="gene ID" value="Gmet_1920"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1920"/>
    <dbReference type="eggNOG" id="ENOG502ZJ6E">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_176910_0_0_7"/>
    <dbReference type="OMA" id="DTCTCKD"/>
    <dbReference type="OrthoDB" id="1986542at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="89" mass="10091" checksum="80EEF21EE701BF27" modified="2005-11-22" version="1">MEENAKQQRLCTEIQLFDLCDKGPVDVCGHRDGRYCTKGDILARFEAIADDDRSPEQYFADELDDVEGADDLGYDEAFGVDEYGEEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UI4</accession>
    <name>Q39UI4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein PulO, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pulO</name>
        <name evidence="2" type="ordered locus">Gmet_1861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511985.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1861"/>
    <dbReference type="EnsemblBacteria" id="ABB32090">
        <property type="protein sequence ID" value="ABB32090"/>
        <property type="gene ID" value="Gmet_1861"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1861"/>
    <dbReference type="eggNOG" id="ENOG50345N1">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125907_0_0_7"/>
    <dbReference type="OMA" id="QVEWFSK"/>
    <dbReference type="OrthoDB" id="1890627at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043683">
        <property type="term" value="P:type IV pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043107">
        <property type="term" value="P:type IV pilus-dependent motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007445">
        <property type="entry name" value="PilO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribosomal_S6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04350">
        <property type="entry name" value="PilO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="181" mass="20218" checksum="A346597D9FCC16E8" modified="2005-11-22" version="1">MTRNQFLEVLKAKRMSIAVILVLILVNMGIVMYSQLVQEPKLVKLQNEWTEKRRLVTGGGDLGTIYRQGTADLAAFQERIPLKRDFTRQMMEVFEIAANNGLKVKGITYKPEAQKEANLVVYGVTMSLDGQYAGIKSFISDLQCHGGLLTIDSISLSNTSMIEEAVSLKMQLSAYLRPEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UI5</accession>
    <name>Q39UI5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein PulP, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pulP</name>
        <name evidence="2" type="ordered locus">Gmet_1860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511986.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1860"/>
    <dbReference type="EnsemblBacteria" id="ABB32089">
        <property type="protein sequence ID" value="ABB32089"/>
        <property type="gene ID" value="Gmet_1860"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1860"/>
    <dbReference type="eggNOG" id="ENOG5033702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1270797_0_0_7"/>
    <dbReference type="OMA" id="KNRPGMA"/>
    <dbReference type="OrthoDB" id="1846272at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="204" mass="22562" checksum="E8A1F65EB934F956" modified="2005-11-22" version="1">MNRQRLILSILLVVLVVAAIVSYIRMPCQQTVSKVTSPPTKVSRSPKPNGAAATDDRKLRLDLLECTSNRFAGFRRNIFRPIFRGETQQSRPLPLTLPKAVPLPPPPAAPVALPPPMPVAPQPPQVVRDMAKFTFLGFLKKDNHKTIFLARDKEIILVRQGDKIAGNYEATTITDEALSIRSLTDGSEMVIPLVENRPLAGQIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UJ8</accession>
    <name>Q39UJ8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">zf-TFIIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32076.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511999.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1847"/>
    <dbReference type="EnsemblBacteria" id="ABB32076">
        <property type="protein sequence ID" value="ABB32076"/>
        <property type="gene ID" value="Gmet_1847"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1847"/>
    <dbReference type="eggNOG" id="COG3809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2232701_0_0_7"/>
    <dbReference type="OMA" id="KDHRSWF"/>
    <dbReference type="OrthoDB" id="1802696at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027392">
        <property type="entry name" value="TF_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13453">
        <property type="entry name" value="zf-TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-TFIIB" evidence="1">
        <location>
            <begin position="45"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32076.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="105" mass="12680" checksum="9A05E30637FC10FD" modified="2012-10-31" version="2">MKNIWKEREKALENQYIYKQEQDKIERMQKEERERLVREMCRNRCPKCGDEIKAMTFRGVPLDRCPGCGGVWLGPNDLRILASKDHRSWFEKWFKEENETSEKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UM6</accession>
    <name>Q39UM6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Branched-chain amino acid ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">livF</name>
        <name evidence="5" type="ordered locus">Gmet_1819</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512026.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1819"/>
    <dbReference type="EnsemblBacteria" id="ABB32048">
        <property type="protein sequence ID" value="ABB32048"/>
        <property type="gene ID" value="Gmet_1819"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1819"/>
    <dbReference type="eggNOG" id="COG0410">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="RIFPDMT"/>
    <dbReference type="OrthoDB" id="1475841at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015658">
        <property type="term" value="F:branched-chain amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030660">
        <property type="entry name" value="ABC_branched_ATPase_LivF/BraG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039137">
        <property type="entry name" value="ABC_branched_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="247" mass="27368" checksum="0D7ED9A4F1F36B7B" modified="2005-11-22" version="1">MLKIKNINTFYGKVHALKNISIHLKQGEIVTLIGANGAGKTTILNSISAVTPPATGQIHFDDQDIAGLGPDRIVKLGICQVPEGRQVFKPLSVEDNLDLGAYLRYRGREGRSAIRKDLDDMYALFPRLHERRKQAAGTLSGGEQQMLAMGRALMARPKLLLLDEPSMGLAPLVVQEIFRVIEQLRSERGTTVLLVEQNAKAALKMADRGYVLETGKVVLEGIASELLENKEVQRAYLGKDKKEIWER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UW5</accession>
    <name>Q39UW5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glu/Leu/Phe/Val dehydrogenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513375.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1728"/>
    <dbReference type="EnsemblBacteria" id="ABB31959">
        <property type="protein sequence ID" value="ABB31959"/>
        <property type="gene ID" value="Gmet_1728"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1728"/>
    <dbReference type="eggNOG" id="COG2902">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010860_0_0_7"/>
    <dbReference type="OMA" id="YIYLGPD"/>
    <dbReference type="OrthoDB" id="113771at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:cellular amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006096">
        <property type="entry name" value="Glu/Leu/Phe/Val_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00208">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00839">
        <property type="entry name" value="ELFV_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELFV_dehydrog" evidence="1">
        <location>
            <begin position="614"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="992" mass="112535" checksum="F225966C0E441E18" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UY0</accession>
    <name>Q39UY0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">etfB-7</name>
        <name evidence="4" type="ordered locus">Gmet_1713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF beta-subunit/FixA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514141.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1713"/>
    <dbReference type="EnsemblBacteria" id="ABB31944">
        <property type="protein sequence ID" value="ABB31944"/>
        <property type="gene ID" value="Gmet_1713"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1713"/>
    <dbReference type="eggNOG" id="COG2086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060196_1_0_7"/>
    <dbReference type="OMA" id="YNGGMVP"/>
    <dbReference type="OrthoDB" id="1027643at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01714">
        <property type="entry name" value="ETF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012255">
        <property type="entry name" value="ETF_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033948">
        <property type="entry name" value="ETF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21294">
        <property type="entry name" value="PTHR21294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000090">
        <property type="entry name" value="Beta-ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="23"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="258" mass="27961" checksum="61CFD8522B69D70E" modified="2005-11-22" version="1">MKILVCVKQVPDMESRFKPDGSGTWFEETDLAFRMNEYDEYAVEQAVQLKEQLGNEPEVTVLSIGPDRVNEAIKKALAMGCDKGAHIQDPAPQGKDPWQIASIIAQYARTEGFDLVFTGMQSQDRGSAQVGVLVAELLGFACATTLVGFAFADGVVTAKRELEGGIKGVAKLRLPAVVTCQLGLNIPRYPTLPNIMKAKKKEILAIPVADLLKEEAVAATARFYPPARKGGGIVLEGDVGNLVEQLYGILKEKTTVLR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V65</accession>
    <name>NUSB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Transcription antitermination protein NusB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Antitermination factor NusB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nusB</name>
        <name type="ordered locus">Gmet_1628</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NusB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511436.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V65"/>
    <dbReference type="SMR" id="Q39V65"/>
    <dbReference type="STRING" id="269799.Gmet_1628"/>
    <dbReference type="EnsemblBacteria" id="ABB31859">
        <property type="protein sequence ID" value="ABB31859"/>
        <property type="gene ID" value="Gmet_1628"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1628"/>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087843_3_3_7"/>
    <dbReference type="OMA" id="DRMPVVD"/>
    <dbReference type="OrthoDB" id="1574817at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00073">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011605">
        <property type="entry name" value="NusB_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11078">
        <property type="entry name" value="PTHR11078"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01951">
        <property type="entry name" value="nusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0889">Transcription antitermination</keyword>
    <keyword id="KW-0805">Transcription regulation</keyword>
    <feature type="chain" id="PRO_0000265524" description="Transcription antitermination protein NusB">
        <location>
            <begin position="1"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00073"/>
        </source>
    </evidence>
    <sequence length="138" mass="15243" checksum="EC6D83B044622BFF" modified="2005-11-22" version="1">MGARRLGREIALQLLYSRDYTVGEASSLLEMVFDEAEPGTAAGRAFSDELVRGVLEHRETIDATITEKSKNWAISRMAKVDLNILRLAIYELLYRGDIPKNVTINEAIEVAKKFGTEDSPAFINGILDEVASTLPDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V83</accession>
    <name>Q39V83_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TSCPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511454.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1610"/>
    <dbReference type="EnsemblBacteria" id="ABB31841">
        <property type="protein sequence ID" value="ABB31841"/>
        <property type="gene ID" value="Gmet_1610"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1610"/>
    <dbReference type="eggNOG" id="COG0209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_154569_0_0_7"/>
    <dbReference type="OMA" id="RDISCHR"/>
    <dbReference type="OrthoDB" id="1986828at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024434">
        <property type="entry name" value="TSCPD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12637">
        <property type="entry name" value="TSCPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TSCPD" evidence="1">
        <location>
            <begin position="18"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="109" mass="11309" checksum="4C506475B889F66A" modified="2005-11-22" version="1">MNAQRPQALPGQTLALDTNCGKLYVTVNCDPSSCLPVEIFCRFGKAGGCGSAVMDGMTRMISCGLSAGMAPEEVVSHLRDISCHRGPGTCMDAVAQAVEAVVAQEGDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VD3</accession>
    <name>Q39VD3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1557"/>
    <dbReference type="EnsemblBacteria" id="ABB31791">
        <property type="protein sequence ID" value="ABB31791"/>
        <property type="gene ID" value="Gmet_1557"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1557"/>
    <dbReference type="HOGENOM" id="CLU_2287492_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="101" mass="11717" checksum="DD0BD662988F0B7C" modified="2005-11-22" version="1">MVGHCLTLRDRKVFLNNIIYAINLLGNIPQRLLNFLQQLISTSAGKFTYSFIASRCLRMLTIAKIDLRSQFMTNIRQCAVDYSSHLITATITFRHFLCNFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VQ8</accession>
    <name>Q39VQ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Septum formation initiator family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">divIC</name>
        <name evidence="5" type="ordered locus">Gmet_1432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511636.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1432"/>
    <dbReference type="EnsemblBacteria" id="ABB31666">
        <property type="protein sequence ID" value="ABB31666"/>
        <property type="gene ID" value="Gmet_1432"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1432"/>
    <dbReference type="eggNOG" id="COG2919">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134863_1_0_7"/>
    <dbReference type="OMA" id="LRINHLH"/>
    <dbReference type="OrthoDB" id="2014691at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023081">
        <property type="entry name" value="Cell_div_FtsB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007060">
        <property type="entry name" value="FtsL/DivIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37485">
        <property type="entry name" value="PTHR37485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04977">
        <property type="entry name" value="DivIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="110" mass="12905" checksum="FA8A90A5ECD8204F" modified="2005-11-22" version="1">MRKRMYLVPAGCILFILFFTVFGERGLLRIYHLSREKQEIAEKVTEVRGENEKLKREIEALKTDRRYLESIARKDFGLVRPNEVVYQFPSSDKAQAKTQQPVSSAVEKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VR3</accession>
    <name>Q39VR3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Tyrosine recombinase XerD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11 15" type="primary">xerD</name>
        <name evidence="15" type="ordered locus">Gmet_1427</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 'phage' integrase family. XerD subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511641.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1427"/>
    <dbReference type="EnsemblBacteria" id="ABB31661">
        <property type="protein sequence ID" value="ABB31661"/>
        <property type="gene ID" value="Gmet_1427"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1427"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_6_7"/>
    <dbReference type="OMA" id="HRFLYAE"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01807">
        <property type="entry name" value="Recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011932">
        <property type="entry name" value="Recomb_XerD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02225">
        <property type="entry name" value="recomb_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="6 11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0229">DNA integration</keyword>
    <keyword evidence="9 11" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="8 11 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="14">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="13">
        <location>
            <begin position="106"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="170"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="11">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB31661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="295" mass="32981" checksum="E2F3ADA0CCF90253" modified="2005-11-22" version="1">MNQYLDLFLNYLLVEKGLAKNSLDSYGRDMIRYLDFLEKRNCGEPSAVRPVDVADFLAHLKDCGLAPRSRARALSAVRMFHRFLLVEGYAEANPTAIIEAPKTLAKLPQILAGREVEALLAAPGSDSAQDMRDRAMLELLYATGLRVSELVGLGLRDVNVTAGYLMAFGKGGKERLVPMGESACAAVSRYLAEARPEMDRNGDNAYLFLTRLGDRMTRQAFWNIIKKRAIEAGIRKTISPHTLRHSFATHLLENGADLRSVQAMLGHADLATTQIYTHVTRERLKRIHEEYHPRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VS5</accession>
    <name>SYFA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="1">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
            <shortName evidence="1">PheRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pheS</name>
        <name type="ordered locus">Gmet_1415</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per tetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511652.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39VS5"/>
    <dbReference type="SMR" id="Q39VS5"/>
    <dbReference type="STRING" id="269799.Gmet_1415"/>
    <dbReference type="EnsemblBacteria" id="ABB31649">
        <property type="protein sequence ID" value="ABB31649"/>
        <property type="gene ID" value="Gmet_1415"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1415"/>
    <dbReference type="eggNOG" id="COG0016">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025086_0_1_7"/>
    <dbReference type="OMA" id="DWHNFTA"/>
    <dbReference type="OrthoDB" id="469058at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00281">
        <property type="entry name" value="Phe_tRNA_synth_alpha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004530">
        <property type="entry name" value="Phe-tRNA-synth_IIc_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004188">
        <property type="entry name" value="Phe-tRNA_ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022911">
        <property type="entry name" value="Phe_tRNA_ligase_alpha1_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF41">
        <property type="entry name" value="PTHR11538:SF41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02912">
        <property type="entry name" value="Phe_tRNA-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000231984" description="Phenylalanine--tRNA ligase alpha subunit">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>shared with beta subunit</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00281"/>
        </source>
    </evidence>
    <sequence length="338" mass="37646" checksum="819138E5B63A6F8E" modified="2005-11-22" version="1">MKEQLDGLLQSALKEIDGAGSEEALQELRIKYLGKKGALTAVMKGLGALSAEERPVVGQLANTVKDQLEAHLDETLAQVRDASKRERLQRERLDVTLPGRRLPHGTKHPITLVIEEISEIFAGLGFRVAEGPEVELDFYNFEALNFPKDHPARDMQDTFFVDDSILLRTHTSPVQVRTMLKHAPPVRIISPGTVYRCDSDATHSPMFHQIEGLMVDTGVTFGDLKGILTNFVNQYFGKGIGVRLRPSFFPFTEPSAEVDIACVMCKGKGCRVCKESGWLEILGAGMIDPEVYRHVGYDPETISGFAFGMGVERVAMLKYGIGDLRLFFDNDVRFLQQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W19</accession>
    <name>Q39W19_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1320"/>
    <dbReference type="EnsemblBacteria" id="ABB31555">
        <property type="protein sequence ID" value="ABB31555"/>
        <property type="gene ID" value="Gmet_1320"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1320"/>
    <dbReference type="eggNOG" id="COG1669">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130257_10_3_7"/>
    <dbReference type="OMA" id="TMNPFLK"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002934">
        <property type="entry name" value="Polymerase_NTP_transf_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01909">
        <property type="entry name" value="NTP_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transf_2" evidence="1">
        <location>
            <begin position="24"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="106" mass="12065" checksum="533528AC3F36A75D" modified="2005-11-22" version="1">MIKGCGDVMRPTKEELLAFLQSKKTDFRQEFTIQKLGVFGSFARGTATDESDIDLVVELEKPDLYNLIGIKQAVEEEFGGKVDVVRLRPHMNSMLKKRIEQDAIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W44</accession>
    <name>Q39W44_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="4">3.3.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">S-adenosyl-L-homocysteine hydrolase</fullName>
            <shortName evidence="4">AdoHcyase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 9" type="primary">ahcY</name>
        <name evidence="9" type="ordered locus">Gmet_1294</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4 6">
            <text>H2O + S-adenosyl-L-homocysteine = adenosine + L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.3.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4 6">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="4 6">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 6">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4 7">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <dbReference type="EC" id="3.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512072.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1294"/>
    <dbReference type="EnsemblBacteria" id="ABB31530">
        <property type="protein sequence ID" value="ABB31530"/>
        <property type="gene ID" value="Gmet_1294"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1294"/>
    <dbReference type="eggNOG" id="COG0499">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025194_2_1_7"/>
    <dbReference type="OMA" id="NKYGCRE"/>
    <dbReference type="OrthoDB" id="522981at2"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00563">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="PTHR23420"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4 6" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AdoHcyase_NAD" evidence="8">
        <location>
            <begin position="237"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="203"/>
            <end position="205"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="266"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="345"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="390"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="476" mass="52290" checksum="DFDCDA717D7E0457" modified="2005-11-22" version="1">MSTTSTPTATTAAFTDCHVRDLSLAAWGRKEMVIAETEMPGLMAIREEYAASQPLKGARIAGSLHMTIQTAMLIETLTALGAEVRWASCNIFSTQDHAAAAIAAAGIPVFAYKGESLEEYWEFTHRIFEWHDGGTPNMILDDGGDATLLLHLGSDAEKDPSVVANPTCEEEQFLFAAIKKRLAEKPEWYSKTAAAIKGVTEETTTGVHRLYQMHEKGRLKFPAINVNDSVTKSKFDNIYGCRESLVDGIKRATDVMVAGKVAVICGYGEVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYKVVTMEWAADKADIFVTTTGNINVITHDHMKAMKHNAIVCNIGHFDNEIEVAALKQYQWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSYVMSSSFANQTLAQMELFCNPGKYPVGVYMLPKELDEKVARLQLKTLGAMLTELTEEQAAYIGVPKAGPYKTDHYRY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W86</accession>
    <name>PYRH_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Uridylate kinase</fullName>
            <shortName evidence="1">UK</shortName>
            <ecNumber evidence="1">2.7.4.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Uridine monophosphate kinase</fullName>
            <shortName evidence="1">UMP kinase</shortName>
            <shortName evidence="1">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrH</name>
        <name type="ordered locus">Gmet_1252</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible phosphorylation of UMP to UDP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + UMP = ADP + UDP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.22"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP. Inhibited by UTP.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; UDP from UMP (UMPK route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UMP kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.22" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512115.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W86"/>
    <dbReference type="SMR" id="Q39W86"/>
    <dbReference type="STRING" id="269799.Gmet_1252"/>
    <dbReference type="EnsemblBacteria" id="ABB31488">
        <property type="protein sequence ID" value="ABB31488"/>
        <property type="gene ID" value="Gmet_1252"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1252"/>
    <dbReference type="eggNOG" id="COG0528">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033861_0_0_7"/>
    <dbReference type="OMA" id="PIIVFDM"/>
    <dbReference type="OrthoDB" id="1043239at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00275"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04254">
        <property type="entry name" value="AAK_UMPK-PyrH-Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01220_B">
        <property type="entry name" value="PyrH_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011817">
        <property type="entry name" value="Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015963">
        <property type="entry name" value="Uridylate_kinase_bac"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005650">
        <property type="entry name" value="Uridylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="SSF53633"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02075">
        <property type="entry name" value="pyrH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0021">Allosteric enzyme</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000073141" description="Uridylate kinase">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Involved in allosteric activation by GTP" evidence="1">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="12"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="135"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>UMP</name>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01220"/>
        </source>
    </evidence>
    <sequence length="239" mass="25533" checksum="4022DCA997D62108" modified="2005-11-22" version="1">MGTPYYKRVLLKLSGEALAGDQGYGIDPLTITTIAAEIKEVVASGAQLALVIGGGNIFRGLAASSKGMDRASADYMGMLATMINSLAMQDALEKIGVDTRVQSAIAMQEVAEPYIRRRAMRHLEKGRVVIFGAGTGNPYFTTDTAASLRAMEIGADVILKGTKVDGVYSADPKKDPTAQKYPRLTYLEVLKKGLQVMDATATSLCMDNNLPIIVFDITTYGNIKKVVCGEEIGTVVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WB4</accession>
    <name>Q39WB4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA repair exonuclease SbcCD, D subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">sbcD</name>
        <name evidence="2" type="ordered locus">Gmet_1223</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512146.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1223"/>
    <dbReference type="EnsemblBacteria" id="ABB31460">
        <property type="protein sequence ID" value="ABB31460"/>
        <property type="gene ID" value="Gmet_1223"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1223"/>
    <dbReference type="eggNOG" id="COG0420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026621_0_1_7"/>
    <dbReference type="OMA" id="FVYAMKW"/>
    <dbReference type="OrthoDB" id="1831911at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="3"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="376" mass="41623" checksum="8268CFF14E29C0B2" modified="2005-11-22" version="1">MTIRILHTADLHLGSSLKNFGELARERRRDFLKTFDRIVNLAIKREVDCLLVAGDLFDATQVDAETVGRVQDGFERLSGRGISVVLIPGTHDNVVSAESVYNRTTFAGAHILKDPVVTDPFALEIRGATVHFYGFAYRSDRSREALESMRRREGGGIHVGLLHGSLKGSPEWEMRKKDIPFTTAELAALGLDYIALGHYHNVGCLEDQGRVVACYPGSPEGKKFGENGERHVLIVEVGEGSAVVEKVPVQSRIMDELTVDASLFPEAGALEGELARLASPDLIARIRLAGTVEDPLDIANLAGRLQGTYAWLELLDETEIYNSDHVKRMEREDSIRGLFIRKVHARFEKAESEAEQELCRDALKLVMGRFMRGGGD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WD1</accession>
    <name>FPG_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Formamidopyrimidine-DNA glycosylase</fullName>
            <shortName evidence="2">Fapy-DNA glycosylase</shortName>
            <ecNumber evidence="2">3.2.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase MutM</fullName>
            <shortName evidence="2">AP lyase MutM</shortName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mutM</name>
        <name evidence="2" type="synonym">fpg</name>
        <name type="ordered locus">Gmet_1206</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-monophospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.23" evidence="2"/>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512164.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39WD1"/>
    <dbReference type="SMR" id="Q39WD1"/>
    <dbReference type="STRING" id="269799.Gmet_1206"/>
    <dbReference type="EnsemblBacteria" id="ABB31443">
        <property type="protein sequence ID" value="ABB31443"/>
        <property type="gene ID" value="Gmet_1206"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1206"/>
    <dbReference type="eggNOG" id="COG0266">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038423_1_1_7"/>
    <dbReference type="OMA" id="GVHLRMT"/>
    <dbReference type="OrthoDB" id="1162346at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00103">
        <property type="entry name" value="Fapy_DNA_glycosyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="DNA_glyclase/AP_lyase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015887">
        <property type="entry name" value="DNA_glyclase_Znf_dom_DNA_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020629">
        <property type="entry name" value="Formamido-pyr_DNA_Glyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="MutM-like_N-ter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000214">
        <property type="entry name" value="Znf_DNA_glyclase/AP_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010663">
        <property type="entry name" value="Znf_FPG/IleRS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06827">
        <property type="entry name" value="zf-FPG_IleRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="SSF81624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00577">
        <property type="entry name" value="fpg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01242">
        <property type="entry name" value="ZF_FPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51066">
        <property type="entry name" value="ZF_FPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0238">DNA-binding</keyword>
    <keyword id="KW-0326">Glycosidase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="initiator methionine" description="Removed" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000228435" description="Formamidopyrimidine-DNA glycosylase">
        <location>
            <begin position="2"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="FPG-type" evidence="2">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with DNA" evidence="2">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="3"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for beta-elimination activity" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for delta-elimination activity" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00103"/>
        </source>
    </evidence>
    <sequence length="267" mass="29698" checksum="6B9DD92E19982328" modified="2007-01-23" version="3">MPELPEVELTRRRLERELTGKRIDRVVVRTPKLRFPIPQELHVSLPGRTVRSVGRRGKYLLFDCETGWLIVHLGMTGFLRLVAGTAPPGKHDHLDIVFADGTVLRFHDPRKFGTVAWTTDAPATHPLLAAIGPEPLTATFDGAYLFAVTRTRRVAVKQLLMNAAIVAGVGNIYANEALFRAGIRPDRPASSLGRPECERLARTVREVLQESIDQGSTYRVEEETVAYHPLNFDVYGRGTDACTRCGGALEEIRLGNRSTVFCPRCQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WI2</accession>
    <name>Q39WI2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, UPF0118 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1154</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513419.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1154"/>
    <dbReference type="EnsemblBacteria" id="ABB31392">
        <property type="protein sequence ID" value="ABB31392"/>
        <property type="gene ID" value="Gmet_1154"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1154"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041771_2_2_7"/>
    <dbReference type="OMA" id="EIAYVYQ"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="358" mass="38485" checksum="FA751F312C4555F0" modified="2005-11-22" version="1">MDRGHFYALVAFSFCAILGYVVYAIVSPFLNSLGWAAVIGILTFPIYRRLRAGLGARDTLAAGLMTPATVLTLVVPFVGLTFFLVQEAAVAYGFLEKIAADGGESLVMSIQNHPVVKPWIARIEAYTGPLGFEIDTRFLPEMKEVAARVLNYSKEIVKNVFIFSIKLLLMVITLFFIYRDGERVQRHALAVIPLTEANKQILTDTVRRVLKAVMYGVFLTCLVQGALGGIGFWAAGLPSPLLFGAIMAVCALIPVVGTGLIWLPAAIYLLANGEVVKGIGLIIWGFVAVSSIDNVIRPFFISGRAKLPVLVIAIGGLGGLASFGLLGAVAGPIVLALFLALFEMYRDEVETGEGRGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WI5</accession>
    <name>Q39WI5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513416.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1151"/>
    <dbReference type="MEROPS" id="S54.027"/>
    <dbReference type="EnsemblBacteria" id="ABB31389">
        <property type="protein sequence ID" value="ABB31389"/>
        <property type="gene ID" value="Gmet_1151"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1151"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055068_5_1_7"/>
    <dbReference type="OMA" id="IAYWAHA"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="78"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="240" mass="26260" checksum="45E08463CF555EE6" modified="2005-11-22" version="1">MIPIKDYNPTRRFPLVSVAFIVLNVIVFILDRISGHYEPLIIETSRGLIRTRQFVGGLSADFALVPAALTSHPLLAWPTVFSSMFLHGNWLHIGSNMLYLWIFGNNVEDVLGRGRFILFYFTCGAVAALAQVMSAPGSDIPMVGASGAVAGVMGAYLLLFPKARILTLVPILFFFTFLEVPAFIIIGYWVLIQFLNATWLGGGELLRGGVAYFAHIGGFVAGVTFVLLARMGRRGGYGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WS5</accession>
    <name>Q39WS5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Periplasmically oriented, membrane-bound formate dehydrogenase, major subunit, selenocysteine-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">fdnG</name>
        <name evidence="11" type="ordered locus">Gmet_1059</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Periplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1059"/>
    <dbReference type="KEGG" id="gme:Gmet_1059"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3383">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_1_2_7"/>
    <dbReference type="OMA" id="SELWFFY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047111">
        <property type="term" value="F:formate dehydrogenase (cytochrome-c-553) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006443">
        <property type="entry name" value="Formate-DH-alph_fdnG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027467">
        <property type="entry name" value="MopterinOxRdtase_cofactor_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01553">
        <property type="entry name" value="formate-DH-alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00551">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 9" id="KW-0408">Iron</keyword>
    <keyword evidence="8 9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0711">Selenium</keyword>
    <keyword evidence="11" id="KW-0712">Selenocysteine</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="10">
        <location>
            <begin position="40"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="11">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1010" mass="112299" checksum="BE6BCE4DA18CD535" modified="2008-02-26" version="2"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-05-20" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WU7</accession>
    <name>MOAC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cyclic pyranopterin monophosphate synthase</fullName>
            <ecNumber evidence="1">4.6.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Molybdenum cofactor biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">moaC</name>
        <name type="ordered locus">Gmet_1037</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:49580"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59648"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.6.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer; trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MoaC family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513210.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39WU7"/>
    <dbReference type="SMR" id="Q39WU7"/>
    <dbReference type="STRING" id="269799.Gmet_1037"/>
    <dbReference type="EnsemblBacteria" id="ABB31277">
        <property type="protein sequence ID" value="ABB31277"/>
        <property type="gene ID" value="Gmet_1037"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1037"/>
    <dbReference type="eggNOG" id="COG0315">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074693_1_0_7"/>
    <dbReference type="OMA" id="IWDMVKS"/>
    <dbReference type="OrthoDB" id="1595361at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061799">
        <property type="term" value="F:cyclic pyranopterin monophosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01420">
        <property type="entry name" value="MoaC_PE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01224_B">
        <property type="entry name" value="MoaC_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023045">
        <property type="entry name" value="Mo_CF_biosynth-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036522">
        <property type="entry name" value="MoaC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002820">
        <property type="entry name" value="Mopterin_CF_biosynth-C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01967">
        <property type="entry name" value="MoaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55040">
        <property type="entry name" value="SSF55040"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00581">
        <property type="entry name" value="moaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000085673" description="Cyclic pyranopterin monophosphate synthase">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="112"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01224"/>
        </source>
    </evidence>
    <sequence length="160" mass="16853" checksum="6D53676CD5C2A4AF" modified="2005-11-22" version="1">MSFNHFDDQGRAIMVDVSGKQPTLRTATAAATVAMKPETLADLLAGRTTKGDVLGVARLAGIAAAKKTPELIPLSHPLAIHHAAVDFETEPETGTITVKATVRAFERTGVEMEAMTSAAVAALTIYDMCKGADKGITIGDICLLFKEGGKSGTWQREEPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WY3</accession>
    <name>Q39WY3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514692.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0999"/>
    <dbReference type="EnsemblBacteria" id="ABB31241">
        <property type="protein sequence ID" value="ABB31241"/>
        <property type="gene ID" value="Gmet_0999"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0999"/>
    <dbReference type="eggNOG" id="COG1600">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030790_1_0_7"/>
    <dbReference type="OMA" id="RQEEYGW"/>
    <dbReference type="OrthoDB" id="1478472at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004453">
        <property type="entry name" value="QueG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30002">
        <property type="entry name" value="PTHR30002"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="174"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="344" mass="38894" checksum="FB4FA64ED378E17B" modified="2005-11-22" version="1">MSTDNLALNIREKAMEAGFDHCGIVKIDALADYVSRLEERAAAFPRSKPFYDFLSKLGTPQAAHEWGKSVIVCAMRYGKYRIPNRADRHIGKLYLYGGYRQPAYSQEYAGMAGFEAFLAAEGIRFAKDVFGIAPARLCAAQANLGVIRNNNFLYTEHGSWVWLETWLIDRELEYRESPNTLPSCPPGCSKCIDACPTGALKAPFLTDMGTCIARLTYSPSGEAPEPLRESMGTWLYGCDECQNACPMNKGRWEEKEEYPRLEELSRHISLEKIAEMDEHAVSDILSPMFWIIGKEKLWMWKCNVIRAMVNGKDPGHHSTIRKLCDDGNENVRRTAEWACRQLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WY5</accession>
    <name>Q39WY5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATPase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514690.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0997"/>
    <dbReference type="EnsemblBacteria" id="ABB31239">
        <property type="protein sequence ID" value="ABB31239"/>
        <property type="gene ID" value="Gmet_0997"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0997"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="LMPWRSA"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="27"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="63"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="278" mass="31323" checksum="E9DE9100B00E98EC" modified="2005-11-22" version="1">MEFGNRTKTQAPPPQNVSAKPLRAKLLQLTNVSKTFQSVTQAVEALAPSNLEIEEGEFVVFFGPSGCGKSTLLDIIAGFETPTTGEVLFEGSPVTMPGSDRLMMFQEHTLFPWLNVVRNVMYGLKHKREFRFRLRKQRETARSWLKMIGLEEFETSLVHELSGGMKQRVALARALAPDPKVLLVDEPFPALDALVRTKLYADLQDILVRTGKTIISVTHDPREAACLADRVLVFTPRPGRVQKEIRVNLPRPRDINDQEVGEYASRIMEELENPPDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WZ9</accession>
    <name>Q39WZ9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Biotin carboxyl carrier protein of acetyl-CoA carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">accB</name>
        <name evidence="7" type="ordered locus">Gmet_0983</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 5">This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 5">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514378.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0983"/>
    <dbReference type="EnsemblBacteria" id="ABB31225">
        <property type="protein sequence ID" value="ABB31225"/>
        <property type="gene ID" value="Gmet_0983"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0983"/>
    <dbReference type="eggNOG" id="COG0511">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_3_1_7"/>
    <dbReference type="OMA" id="IKSPIIG"/>
    <dbReference type="OrthoDB" id="1938042at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001249">
        <property type="entry name" value="AcCoA_biotinCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01071">
        <property type="entry name" value="ACOABIOTINCC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00531">
        <property type="entry name" value="BCCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0092">Biotin</keyword>
    <keyword evidence="5" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="6">
        <location>
            <begin position="81"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="159" mass="17151" checksum="3280DB0A53EF70CC" modified="2005-11-22" version="1">MDIKDLKSLIKMVTETDITEFELEGAEEKIRIKRGCTAPMVQYQAPQPMVAMQPAMVQAAAPAASAAPVEAAAPAAAKAKGNEITSPIVGTFYRAPAPDAAPYVEVGQIIEKGQVLCIVEAMKLMNEIEAEYRCKIVEICKENAQPVEFGEALFIVEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X32</accession>
    <name>Q39X32_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylacetate--coenzyme A ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">paaK-3</name>
        <name evidence="3" type="ordered locus">Gmet_0950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514433.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0950"/>
    <dbReference type="EnsemblBacteria" id="ABB31192">
        <property type="protein sequence ID" value="ABB31192"/>
        <property type="gene ID" value="Gmet_0950"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0950"/>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035301_1_1_7"/>
    <dbReference type="OMA" id="FGSERWG"/>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047475">
        <property type="term" value="F:phenylacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05913">
        <property type="entry name" value="PaaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028154">
        <property type="entry name" value="AMP-dep_Lig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011880">
        <property type="entry name" value="PA_CoA_ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14535">
        <property type="entry name" value="AMP-binding_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="80"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C_2" evidence="2">
        <location>
            <begin position="337"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="433" mass="47889" checksum="29E87A90FEEC15E7" modified="2005-11-22" version="1">MLTRFPAPFSSPADLERLQLAGVQWTVAHAWNNSPFYRERFQQAGVSPEDIRTLDDLRRLPFTTADDLRAGYPFPLRSASFEEIVRIHSSSGTTGKRKILCYTQKDLDDWARMFCRCYELAGVTREDRVQICVGYGLWTAGIGFQAACERYGALAVPVGPGNLELQTTFLTDVQSTVVCCTASMGLLLAEEVQRRGLRDRIKVRKVILGAERSSEAMLAKIREGLGAESVHDITGLTEVYGPGTGLSCAAPGANGAVHYWADYYLLEILDPETLQPVAPGEVGEMVFTTLRKEAAPLIRYRSRDLTRLIPGDCPCGCTFPRHDRILGRSDDVVIFRGVNIYPGQIDEILDTVAGVGSEFQVVLDHGADGRDYMTIRVERGEDGAPADDPALARKVASAVKHSLMVSCEVVVLPYGELPRSEGKTRRMYDNRKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XB1</accession>
    <name>Q39XB1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Helix-turn-helix iron-sulfur cluster-binding transcriptional regulator IscR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">iscR-2</name>
        <name evidence="1" type="ordered locus">Gmet_0871</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513017.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0871"/>
    <dbReference type="EnsemblBacteria" id="ABB31113">
        <property type="protein sequence ID" value="ABB31113"/>
        <property type="gene ID" value="Gmet_0871"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0871"/>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_107144_0_0_7"/>
    <dbReference type="OMA" id="YGLTIMM"/>
    <dbReference type="OrthoDB" id="1794390at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33221">
        <property type="entry name" value="PTHR33221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00738">
        <property type="entry name" value="rrf2_super"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="142" mass="15742" checksum="476D2BFAB5364227" modified="2005-11-22" version="1">MRLSTRAQYAVRAMVDLSLHSEGRPVSLKDIALREDIPLNYLEQLFNRLRRGAIVESVRGPGGGYLLARESSAIRVGEIVATVEEPLTPVSCMDKGKGRCTRTAACTTHNVWEMLGERIRTFLDSITLEDLVIEARGRGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XI1</accession>
    <name>Q39XI1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphonoacetate hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">phnA</name>
        <name evidence="4" type="ordered locus">Gmet_0801</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the YjdM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514388.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0801"/>
    <dbReference type="EnsemblBacteria" id="ABB31043">
        <property type="protein sequence ID" value="ABB31043"/>
        <property type="gene ID" value="Gmet_0801"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0801"/>
    <dbReference type="eggNOG" id="COG2824">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_134486_0_1_7"/>
    <dbReference type="OMA" id="SCLYEWN"/>
    <dbReference type="OrthoDB" id="1507972at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004624">
        <property type="entry name" value="YjdM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013988">
        <property type="entry name" value="YjdM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013987">
        <property type="entry name" value="YjdM_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30305:SF3">
        <property type="entry name" value="PTHR30305:SF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03831">
        <property type="entry name" value="YjdM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08274">
        <property type="entry name" value="YjdM_Zn_Ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00686">
        <property type="entry name" value="phnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjdM_Zn_Ribbon" evidence="3">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="YjdM" evidence="2">
        <location>
            <begin position="46"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="113" mass="12241" checksum="E890054236E4E21A" modified="2005-11-22" version="1">MSDMPKCPQCSSEYTYEDGTMYVCPECAHEWGKETAAESGDGSRVVRDAHGNVLSDGDTVTVIKDLKIKGSSSVIKVGTKARNIRLVEGDHDIDCKIDGIGAMQLKSEFVKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XP2</accession>
    <name>Q39XP2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514457.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0740"/>
    <dbReference type="EnsemblBacteria" id="ABB30982">
        <property type="protein sequence ID" value="ABB30982"/>
        <property type="gene ID" value="Gmet_0740"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0740"/>
    <dbReference type="eggNOG" id="COG3162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123372_3_1_7"/>
    <dbReference type="OMA" id="AQFVMTW"/>
    <dbReference type="OrthoDB" id="1906817at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007436">
        <property type="entry name" value="DUF485"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04341">
        <property type="entry name" value="DUF485"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="102" mass="11936" checksum="B82A73D43DDAD949" modified="2005-11-22" version="1">MAEKQYDWGAIAKNPKFVELHRKKTTFLVGWWVFSTVFYFLLPIGAAYAPGLFKIKILGRINFGYLFALSQFFVSWGIAMYYAHVANKDFDRLTRELVDELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XR8</accession>
    <name>Q39XR8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(+) diphosphatase</fullName>
            <ecNumber evidence="2">3.6.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">nudC</name>
        <name evidence="8" type="ordered locus">Gmet_0714</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.22" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514619.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0714"/>
    <dbReference type="EnsemblBacteria" id="ABB30956">
        <property type="protein sequence ID" value="ABB30956"/>
        <property type="gene ID" value="Gmet_0714"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0714"/>
    <dbReference type="eggNOG" id="COG2816">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037162_0_1_7"/>
    <dbReference type="OMA" id="LPFNAEI"/>
    <dbReference type="OrthoDB" id="1435118at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000210">
        <property type="term" value="F:NAD+ diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015375">
        <property type="entry name" value="NADH_PPase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015376">
        <property type="entry name" value="Znr_NADH_PPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09296">
        <property type="entry name" value="NUDIX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09297">
        <property type="entry name" value="zf-NADH-PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="7">
        <location>
            <begin position="159"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="298" mass="32819" checksum="994198BDE72EB413" modified="2005-11-22" version="1">MPYPDTANLPFNATVIADGFTPEPPDSGGGAGPGVWAVLRGNSLVVEERRGTLALPEGERPQWLSAGRETITIGRWHGRPLRVARMSAQDPLPSPFVAEPFNATGERLDDATLTIGGMAQQILHWERDSRFCARCGAPQERLPGTWGKRCPPCGVEHFPHIHPCAIVLVKRGDEFLLTRKPDWAPGRYGLVAGFLDFGESLEECARREVREETGLEIGAIRYVGSQCWPFPSQLMAGFVAEYAGGEICVDHAELEDARWFSPDAMPESIPPRRSIARWIIDRFAIGDRGPGTRGRENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XT5</accession>
    <name>Q39XT5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Inositol-1-monophosphatase</fullName>
            <ecNumber evidence="6">3.1.3.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">hisN</name>
        <name evidence="7" type="ordered locus">Gmet_0697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>a myo-inositol phosphate + H2O = myo-inositol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24056"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:84139"/>
            <dbReference type="EC" id="3.1.3.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.25" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0697"/>
    <dbReference type="EnsemblBacteria" id="ABB30939">
        <property type="protein sequence ID" value="ABB30939"/>
        <property type="gene ID" value="Gmet_0697"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0697"/>
    <dbReference type="eggNOG" id="COG0483">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044118_0_2_7"/>
    <dbReference type="OMA" id="RVDGYWE"/>
    <dbReference type="OrthoDB" id="1741160at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008934">
        <property type="term" value="F:inositol monophosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052832">
        <property type="term" value="F:inositol monophosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052833">
        <property type="term" value="F:inositol monophosphate 4-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046855">
        <property type="term" value="P:inositol phosphate dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01639">
        <property type="entry name" value="IMPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033942">
        <property type="entry name" value="IMPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020550">
        <property type="entry name" value="Inositol_monophosphatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022337">
        <property type="entry name" value="Inositol_monophosphatase_SuhB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01959">
        <property type="entry name" value="SBIMPHPHTASE"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00630">
        <property type="entry name" value="IMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="28744" checksum="259CEE82896264A3" modified="2005-11-22" version="1">MMKEFLETAIRAARSAGAIQRQRLWEEHDIRFKGEIDLVTEVDRACEDLIVATIRGAHPGHGILAEEGTRDAGMSPHRWIVDPLDGTTNYAHGFPWFCVSIALEIDGEVRLGVIYHPVMDELFTAVKGEGAFVNGRPIRVSSRQPLKQCLLATGFPYDRTRDNENNFANFFSFQFAARAVRRAGAAALDLAYVAAGRLDGYWEVKLKPWDVAAGQLLVTEAGGWVTNHAGEPFAIDDHRILASNGLIHDEMLAVLSGKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XU4</accession>
    <name>Q39XU4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Winged helix transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0688</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514079.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0688"/>
    <dbReference type="EnsemblBacteria" id="ABB30930">
        <property type="protein sequence ID" value="ABB30930"/>
        <property type="gene ID" value="Gmet_0688"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0688"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_30_1_7"/>
    <dbReference type="OMA" id="EFNILHF"/>
    <dbReference type="OrthoDB" id="1020672at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00383">
        <property type="entry name" value="trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001867">
        <property type="entry name" value="OmpR/PhoB-type_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016032">
        <property type="entry name" value="Sig_transdc_resp-reg_C-effctor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00486">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00862">
        <property type="entry name" value="Trans_reg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46894">
        <property type="entry name" value="SSF46894"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51755">
        <property type="entry name" value="OMPR_PHOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="OmpR/PhoB-type" evidence="5">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="OmpR/PhoB-type" evidence="3">
        <location>
            <begin position="124"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="220" mass="24216" checksum="C7250C95AC71ABD0" modified="2005-11-22" version="1">MRILLVEDDRMIGEAVEQALKDAAYAVDWVRDGISASDAVETGEYQLVILDLGLPGRDGLGVLERMRGDGNNAAVLIVTARDALDDRIRGLDLGADDYLVKPFAVGELLARIRAVSRRQTGSAAPLLTNGVVTLDPVSKEAVCGERRCRLTAREFSLLQALLVRPGAILSRDELETRIYGWNEEVESNAVEFLIHSVRKKLGSESIRNVRGMGWMVDRNQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XY0</accession>
    <name>RS4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsD</name>
        <name type="ordered locus">Gmet_0652</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="1">With S5 and S12 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365706.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XY0"/>
    <dbReference type="SMR" id="Q39XY0"/>
    <dbReference type="STRING" id="269799.Gmet_0652"/>
    <dbReference type="EnsemblBacteria" id="ABB30894">
        <property type="protein sequence ID" value="ABB30894"/>
        <property type="gene ID" value="Gmet_0652"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0652"/>
    <dbReference type="eggNOG" id="COG0522">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092403_0_2_7"/>
    <dbReference type="OMA" id="NVVFRMG"/>
    <dbReference type="OrthoDB" id="1211060at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01306_B">
        <property type="entry name" value="Ribosomal_S4_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_S4/S9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_S4/S9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005709">
        <property type="entry name" value="Ribosomal_S4_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_S4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="PTHR11831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="PTHR11831:SF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01017">
        <property type="entry name" value="rpsD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000228895" description="30S ribosomal protein S4">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="98"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01306"/>
        </source>
    </evidence>
    <sequence length="208" mass="24110" checksum="0A63F1D7E70E2425" modified="2005-11-22" version="1">MARYTGPSCRLCRRENMELFLKGERCYTDKCAIKRRNYPPGQHGQGRPKVSNYGIQLREKQKVRRIYGVLEKQFRSYFEEADRMRGVTGENLLSLLERRLDNVVYRLGFASSRTEARILVRHNHFTLNGRKANIPSIQLKAGDVVVLKEKSRKIACINESLDAVVRRGTPQWLELDKEGYKGVVKLLPAREDIAMPIQEQLIVELYSK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XY2</accession>
    <name>RS13_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsM</name>
        <name type="ordered locus">Gmet_0650</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514259.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XY2"/>
    <dbReference type="SMR" id="Q39XY2"/>
    <dbReference type="STRING" id="269799.Gmet_0650"/>
    <dbReference type="EnsemblBacteria" id="ABB30892">
        <property type="protein sequence ID" value="ABB30892"/>
        <property type="gene ID" value="Gmet_0650"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0650"/>
    <dbReference type="eggNOG" id="COG0099">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_103849_1_2_7"/>
    <dbReference type="OMA" id="YRGLRHK"/>
    <dbReference type="OrthoDB" id="1772647at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_S13_S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="30s_Rbsml_prot_S13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_S13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_S13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019980">
        <property type="entry name" value="Ribosomal_S13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_S13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF1">
        <property type="entry name" value="PTHR10871:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="SSF46946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03631">
        <property type="entry name" value="uS13_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000230509" description="30S ribosomal protein S13">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="122" mass="13721" checksum="BA80DB345B13F1E9" modified="2005-11-22" version="1">MARIAGIDLPRNKRIEIALTYIYGIGRTTAQKILAESGVSVDTRTDSLTEAEVAKIREFIDKNIKVEGDLRRDVSMNIKRLMDLGCYRGLRHRKGLPVRGQRTKTNARTRKGPARTVAGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y64</accession>
    <name>Q39Y64_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512264.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0567"/>
    <dbReference type="EnsemblBacteria" id="ABB30810">
        <property type="protein sequence ID" value="ABB30810"/>
        <property type="gene ID" value="Gmet_0567"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0567"/>
    <dbReference type="eggNOG" id="COG0535">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_962276_0_0_7"/>
    <dbReference type="OMA" id="SPITIYW"/>
    <dbReference type="OrthoDB" id="1172757at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023885">
        <property type="entry name" value="4Fe4S-binding_SPASM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027571">
        <property type="entry name" value="GeoRSP_SPASM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13186">
        <property type="entry name" value="SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04304">
        <property type="entry name" value="GeoRSP_SPASM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04085">
        <property type="entry name" value="rSAM_more_4Fe4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPASM" evidence="1">
        <location>
            <begin position="201"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="289" mass="31131" checksum="E18CC117B2B47359" modified="2005-11-22" version="1">MELASPITIYWDLPPDAHEPSRLMGIAADIVPCRPLMVWITCTAPTLPDGLGAVLERFRESSISVIITIALSTRDESVRALAGQGLVREFLLAVDHAGQLDTGEWKGIAPVGISFAVTSRNWRELPDLMHQCPGYGITRLVLPMQRLYGDEPPFFLTSREQQELADALASAGGTSGLTLTIHDPFLWRAFNPGVPFPQGGCQAANTMIAIAPDGGVYPCPSLPVRLGTVGEASLKEIIASMAKKDVRQRLLEHPGACMACGDVAECRGGCRGRAYVVHQSLEGEDPACW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y83</accession>
    <name>Q39Y83_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Germane superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0548</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512244.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0548"/>
    <dbReference type="EnsemblBacteria" id="ABB30791">
        <property type="protein sequence ID" value="ABB30791"/>
        <property type="gene ID" value="Gmet_0548"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0548"/>
    <dbReference type="eggNOG" id="COG5401">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080926_4_1_7"/>
    <dbReference type="OMA" id="MFKEFAN"/>
    <dbReference type="OrthoDB" id="1101485at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019606">
        <property type="entry name" value="GerMN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10646">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00909">
        <property type="entry name" value="Germane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Germane" evidence="2">
        <location>
            <begin position="82"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="195" mass="20918" checksum="61F0559502EF6ED7" modified="2005-11-22" version="1">MKRTKPHSREQLVLAAFLIAAIVFGLLFFGKYQASRELPTTKPEPKPVGTVQVTLFFATPDAEGLGREGRQMAACESLPECVESLVDEVANGPVGDLHPTLPPNAVVHDVRIEGDTAVVDFGDDLLKGLPGGSSAEMAAVYSVVNTICLNYPQIKGVKFLVDGAEVETLTGHLDLRLPIPPDFSLEKNNKKVATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y88</accession>
    <name>Q39Y88_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">dhc2</name>
        <name evidence="2" type="ordered locus">Gmet_0543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512239.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0543"/>
    <dbReference type="EnsemblBacteria" id="ABB30786">
        <property type="protein sequence ID" value="ABB30786"/>
        <property type="gene ID" value="Gmet_0543"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0543"/>
    <dbReference type="eggNOG" id="ENOG5033D3K">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_189784_0_0_7"/>
    <dbReference type="OMA" id="DKGCPAC"/>
    <dbReference type="OrthoDB" id="1924485at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="96" mass="10794" checksum="8575B4A4968C1AAC" modified="2005-11-22" version="1">MKLAKKDWFFIILIIAVFGGFWAISGEVKTKKVPHDDAHKRFYDAFNSGATKIDLDAQCPSCHFEGPGGIPFPKEHPVKPADGPMRCLFCHKFKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YB0</accession>
    <name>Q39YB0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">arsC</name>
        <name evidence="5" type="ordered locus">Gmet_0521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:10137"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:82620"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512217.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0521"/>
    <dbReference type="EnsemblBacteria" id="ABB30764">
        <property type="protein sequence ID" value="ABB30764"/>
        <property type="gene ID" value="Gmet_0521"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0521"/>
    <dbReference type="eggNOG" id="COG0394">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_071415_3_2_7"/>
    <dbReference type="OMA" id="DNAKERC"/>
    <dbReference type="OrthoDB" id="1800563at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="SSF52788"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LMWPc" evidence="4">
        <location>
            <begin position="3"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="140" mass="15553" checksum="718BCA116E2DF196" modified="2005-11-22" version="1">MKHRVLFLCTHNANRSQMAEGLANHFLGGQWEAFSAGTEATAVNPRAIRVMAELGIDISNQRSKNLAEFDGQTFDRVITLCGDATEKCPYFVGGVRREHVGFDDPSRATGTEGEIMAEFRRVRDEMRQELTAHLSGGTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YB2</accession>
    <name>Q39YB2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane protein DUF318</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0519</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPF0718 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512215.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0519"/>
    <dbReference type="EnsemblBacteria" id="ABB30762">
        <property type="protein sequence ID" value="ABB30762"/>
        <property type="gene ID" value="Gmet_0519"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0519"/>
    <dbReference type="eggNOG" id="COG0701">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059148_0_0_7"/>
    <dbReference type="OMA" id="MGKDAWW"/>
    <dbReference type="OrthoDB" id="1559099at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005524">
        <property type="entry name" value="DUF318"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03773">
        <property type="entry name" value="ArsP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="315" mass="34641" checksum="A8AC8E138A59A629" modified="2005-11-22" version="1">MFKPFADYLVFDLFGLSPVSHLGEALDFFIYDTLKIFFLLAVIIFVVAIIRSWFPPERTKRILSHEREYVGNVMAALLGIVTPFCSCSAVPLFIGFVESGVPLGVTFSFLVSSPMVNEVALIMLWGMFGWKIALLYIGMGLLVAIVAGIVIGRLKMEKHVQDYVWEMQVGNAEITEQSWSERFDYAREYTIGLLKKIWPYVVVGIGIGGFIHGYVPQDFLARWAGRDNPFAVPVAVALGVPLYSNAAGVIPIVQALTAKGMAMGTVLAFMMAVTALSLPEAIILKNVLKNRLLAVFFGTVAVAIVIVGYLFNAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YK5</accession>
    <name>Q39YK5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Flagellar biosynthesis protein FlhA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">flhA</name>
        <name evidence="8" type="ordered locus">Gmet_0426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512398.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0426"/>
    <dbReference type="EnsemblBacteria" id="ABB30669">
        <property type="protein sequence ID" value="ABB30669"/>
        <property type="gene ID" value="Gmet_0426"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0426"/>
    <dbReference type="eggNOG" id="COG1298">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015346_3_0_7"/>
    <dbReference type="OMA" id="MAINPGQ"/>
    <dbReference type="OrthoDB" id="436367at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042194">
        <property type="entry name" value="FHIPEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042193">
        <property type="entry name" value="FHIPEP_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042196">
        <property type="entry name" value="FHIPEP_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025505">
        <property type="entry name" value="FHIPEP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006301">
        <property type="entry name" value="FlhA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001712">
        <property type="entry name" value="T3SS_FHIPEP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30161">
        <property type="entry name" value="PTHR30161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00771">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005419">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00949">
        <property type="entry name" value="TYPE3IMAPROT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01398">
        <property type="entry name" value="FlhA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00994">
        <property type="entry name" value="FHIPEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="7" id="KW-1006">Bacterial flagellum protein export</keyword>
    <keyword evidence="3 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="8" id="KW-0969">Cilium</keyword>
    <keyword evidence="8" id="KW-0282">Flagellum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="694" mass="75075" checksum="D80C1E69BE42B1C3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YT6</accession>
    <name>Q39YT6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein YqaA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yqaA</name>
        <name evidence="2" type="ordered locus">Gmet_0345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512316.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0345"/>
    <dbReference type="EnsemblBacteria" id="ABB30588">
        <property type="protein sequence ID" value="ABB30588"/>
        <property type="gene ID" value="Gmet_0345"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0345"/>
    <dbReference type="eggNOG" id="COG1238">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125997_1_0_7"/>
    <dbReference type="OMA" id="WSLLFAW"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="16258" checksum="F27DE5498B06FF7F" modified="2005-11-22" version="1">MEQLLTTHSLPALFGLSFLASTLVPIGSEWLLVTLLLKHHDPALAVGVATVGNWLGACTTYAIGMWGGPFLVRRVLRIDEATERRADRLYGRYGSWSLLFSWLPVIGDPLCLVGGILRVRFIRFSLLVGSGKLARYAFIAWITVRGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YV0</accession>
    <name>Q39YV0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Respiratory nitrate reductase chaperone protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">narJ</name>
        <name evidence="3" type="ordered locus">Gmet_0331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512303.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0331"/>
    <dbReference type="EnsemblBacteria" id="ABB30574">
        <property type="protein sequence ID" value="ABB30574"/>
        <property type="gene ID" value="Gmet_0331"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0331"/>
    <dbReference type="eggNOG" id="COG2180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084469_2_0_7"/>
    <dbReference type="OMA" id="RPACAPY"/>
    <dbReference type="OrthoDB" id="1975985at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020945">
        <property type="entry name" value="DMSO/NO3_reduct_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003765">
        <property type="entry name" value="NO3_reductase_chaperone_NarJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036411">
        <property type="entry name" value="TorD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43680">
        <property type="entry name" value="PTHR43680"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02613">
        <property type="entry name" value="Nitrate_red_del"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89155">
        <property type="entry name" value="SSF89155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00684">
        <property type="entry name" value="narJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="206" mass="22822" checksum="48A024E4FC5655EA" modified="2005-11-22" version="1">MTADIYSSLARMLDYPQEKKSLLWAIGTVQRYLSEEGLECPLDTFGEFMAASTLAELQEEYVATFDFNPAVAPYLGHHLFGDNQKKGAYLIALKGEYGRHGYTPLGNELPDHLPVILWFLAHLVRGGEDDARRSFIDRHVLPGVEKLSDSFAASRRDSPWRPAVEAVRLICGEDSARGEHPAEGIGDGVLEKNRPKTAAHPEVSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z22</accession>
    <name>Q39Z22_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0257</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513574.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0257"/>
    <dbReference type="EnsemblBacteria" id="ABB30502">
        <property type="protein sequence ID" value="ABB30502"/>
        <property type="gene ID" value="Gmet_0257"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0257"/>
    <dbReference type="eggNOG" id="COG2271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_62_0_7"/>
    <dbReference type="OMA" id="VYAGMQI"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="263"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="14"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="417" mass="44802" checksum="1691C54202EC98AA" modified="2005-11-22" version="1">MSNTSRIRRQRWVIFSVLALMYILVYFYRVSLAVVAGDISRELRLTPQQLGSLSGILFYVYAVAQLPLGPMIDRLGSRLVISGCGVLTTIGGLLFSQADTLAMAMAARVFIGIGTASVLMATFTIFSHWFSKQEFGRVSGFMVAIGNLGNLSATAPLALAVAAIGWRSSFLVIGILQAVVTVLVFSMVKDRPPVADPGDAADAARPAGMLDAWGEIFSNPHFWLLGGVSFFWYGNYLALQGLWGGPYLMEVMRLSRAATGQMLMFTSLGFISGSMVVDTVARRLFRSYKKTLLAGQIVLLILMSGFLGTAETLPRPLLALLFFAIGLAVSSGVMIYPIIRSMFSVRIVGTALTSLNFFVLMGAAMTQQIMGVIVGSYGRGAAGASPSAYHAAFLFPVAGLAVAIVAYFFARDYSEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZF4</accession>
    <name>Q39ZF4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0121</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514126.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0121"/>
    <dbReference type="EnsemblBacteria" id="ABB30370">
        <property type="protein sequence ID" value="ABB30370"/>
        <property type="gene ID" value="Gmet_0121"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0121"/>
    <dbReference type="eggNOG" id="ENOG5033IH9">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2220648_0_0_7"/>
    <dbReference type="OMA" id="LRCFECH"/>
    <dbReference type="OrthoDB" id="1839830at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="111" mass="12236" checksum="63F7334F96E0D901" modified="2005-11-22" version="1">MRTAPPLLVALTAILTTGCAMLTSWKSIPPPGGCDQCHTIPISANWQVAYQPAILSDERDRPYFQTEGYTMPQPAKPASPLDIRKVDELPCFECHKSPTPAHKGRVGKFHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZG8</accession>
    <name>Q39ZG8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VWFA superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514112.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0107"/>
    <dbReference type="EnsemblBacteria" id="ABB30356">
        <property type="protein sequence ID" value="ABB30356"/>
        <property type="gene ID" value="Gmet_0107"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0107"/>
    <dbReference type="eggNOG" id="COG3825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059555_0_0_7"/>
    <dbReference type="OMA" id="VWDKREF"/>
    <dbReference type="OrthoDB" id="1121563at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008912">
        <property type="entry name" value="Uncharacterised_CoxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05762">
        <property type="entry name" value="VWA_CoxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="390" mass="44239" checksum="9FEEED900AD3EDF5" modified="2005-11-22" version="1">MFLALYHSLRALKVPVSLTEWLTLLEGLANGLHNQSLEDFYYLSRSLLVKDVAHYDAFDQAFAYCFKDAPIPEDLATRKKVLEWLRDAQAPRRLSEEELARLEALSLDELLRQLEERLRTQDGAHHGGKKWIGTGGTSPFGAGGNHPSGISFAAEGGGGRAVLQAFGRRYRNLRNDLTLDVRQIGVALKRLRDLRECGAEEHLDLEGTIDRTCRNAGEIDLVFARERENQVRVLLIMDSGGSMEPFRALSERLFSAAHGLNHFRDFRAFYFHNCVYEDLYVDLDSDESIPTAEVIREYGKEYRLIFVGDGAMAPYELMSPSGILERYRAGTMSGLDWLRQLADAFGRRAWMNPLPENSWMHYETVPVVGGLFPMFPLTLEGLTRAVRHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZM0</accession>
    <name>Q39ZM0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Iron-sulfur cluster-binding sigma-54-dependent transcriptional regulator, FehydlgC and FeS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_0055</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514179.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0055"/>
    <dbReference type="EnsemblBacteria" id="ABB30304">
        <property type="protein sequence ID" value="ABB30304"/>
        <property type="gene ID" value="Gmet_0055"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0055"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4624">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_71_1_7"/>
    <dbReference type="OMA" id="LNCRACG"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007202">
        <property type="entry name" value="4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04060">
        <property type="entry name" value="FeS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="SSF53920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51656">
        <property type="entry name" value="4FE4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="31"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S" evidence="11">
        <location>
            <begin position="357"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="9">
        <location>
            <begin position="436"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB30304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="756" mass="84161" checksum="BCC298645D146473" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZP3</accession>
    <name>Q39ZP3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VWFA superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30281.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0031"/>
    <dbReference type="EnsemblBacteria" id="ABB30281">
        <property type="protein sequence ID" value="ABB30281"/>
        <property type="gene ID" value="Gmet_0031"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0031"/>
    <dbReference type="eggNOG" id="COG2718">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_603770_0_0_7"/>
    <dbReference type="OMA" id="ARDYNIY"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006698">
        <property type="entry name" value="UPF0229"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30510">
        <property type="entry name" value="PTHR30510"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04285">
        <property type="entry name" value="DUF444"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30281.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="412" mass="46759" checksum="E3B838C5801F8416" modified="2012-10-31" version="2">MKNEDSKIFKIWDISSLAPGPEGSYTTRIRSLDELLERDRLREEDGFPRKIRIGKLIKPGKGKQEKFVVVPTTVEEKFMHDRAPTPPEEEEPMGGTGDEAEGDILGEQPVRPEQGAGSGTAGHGGGEGHELESSAYDLGRILTERFNLPNLKEKGKKSSLSHYTYDLTDRNRGFGQILEKKQTLKRVIETNIALGNIDDVTNIDTTRLLIDPRDRIFRILSRELEYESQALVFFVRDYSGSMEGKASEVICSQHVLIYSWLLYQFARQVETRFVLHDNDAREVPDFYTYYNLRVAGGTRVAAAYKMVNDIVEQESLAKDYNIYVFHGTDGDDWDTNGEETIPELRRMLTYTNRVGITIAEHNAYGSRGATEVERYLKGSGLLDEKPEFLRMDVMGEDADETRIIDGIKRLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>J7LW74</accession>
    <name>J7LW74_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin, RelE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0314"/>
    <dbReference type="EnsemblBacteria" id="AFR42795">
        <property type="protein sequence ID" value="AFR42795"/>
        <property type="gene ID" value="Gmet_0314"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0314"/>
    <dbReference type="eggNOG" id="COG4679">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3136106_0_0_7"/>
    <dbReference type="OMA" id="PHSKAMG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009241">
        <property type="entry name" value="HigB-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05973">
        <property type="entry name" value="Gp49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="113" mass="13142" checksum="51AB97C795A6D9E7" modified="2012-10-31" version="1">MIWTITYYSESLQEEILTMPAGFLGRYLRYTDRMEAYGPDLGMPHTRAMGEGLLELRLKASEGIARVFYCTMVGKKIVMLHQFTKKTDKTPPRELELARRRMKEVKNAHAQKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>J7LWB5</accession>
    <name>J7LWB5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ferredoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3652</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512045.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3652"/>
    <dbReference type="EnsemblBacteria" id="AFR42825">
        <property type="protein sequence ID" value="AFR42825"/>
        <property type="gene ID" value="Gmet_3652"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3652"/>
    <dbReference type="HOGENOM" id="CLU_2934937_0_0_7"/>
    <dbReference type="OMA" id="YTEAGCY"/>
    <dbReference type="OrthoDB" id="2188351at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="60" mass="6713" checksum="3658237376C4759A" modified="2012-10-31" version="1">MKYEEVGCYLEINLATGTIERVALEPEVMREHLGRPGACIGEACEGFCQHSLQTCLRIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="31" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEM3</accession>
    <name>J9JEM3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Menaquinol oxidoreductase complex Cbc6, membrane protein subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cbcQ</name>
        <name evidence="2" type="ordered locus">Gmet_3585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512236.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3585"/>
    <dbReference type="EnsemblBacteria" id="AFR42799">
        <property type="protein sequence ID" value="AFR42799"/>
        <property type="gene ID" value="Gmet_3585"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3585"/>
    <dbReference type="eggNOG" id="COG1290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_132021_0_0_7"/>
    <dbReference type="OMA" id="PVKSAWF"/>
    <dbReference type="OrthoDB" id="1836684at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="153" mass="17019" checksum="3060EA5D628D3A96" modified="2012-10-31" version="1">MAERMEVKNDLRRGPRGSGEYVRSSPHFFRLVKRAFWGGLVALALLAMVIPAPLLDPANPGAPPNPAKSAWFLLWTQEVVSHGNGFAWIIVGLSLWFLALPWLGMHRPERAVWFGEGNRAAAWTTIAVFAAIVSMTVLAMFFRGENWSLVSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PR4</accession>
    <name>Q39PR4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513711.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3555"/>
    <dbReference type="EnsemblBacteria" id="ABB33760">
        <property type="protein sequence ID" value="ABB33760"/>
        <property type="gene ID" value="Gmet_3555"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3555"/>
    <dbReference type="eggNOG" id="COG1950">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120441_2_4_7"/>
    <dbReference type="OMA" id="NALMFWA"/>
    <dbReference type="OrthoDB" id="1925503at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007165">
        <property type="entry name" value="Phage_holin_4_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37309">
        <property type="entry name" value="PTHR37309"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04020">
        <property type="entry name" value="Phage_holin_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="115" mass="11872" checksum="C7D6EB9BD120CB47" modified="2005-11-22" version="1">MLGIILKLIVNAVALFAVVRLVPGISIAGSGTLFLAALVLGFLNAVLRPIISFFTLPITVLTLGLFTLVVNGAVFALAAWIVPGFNIAGIGSAILGALVFSVVSFVLNIIVRPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PS3</accession>
    <name>Q39PS3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3546</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513702.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3546"/>
    <dbReference type="EnsemblBacteria" id="ABB33751">
        <property type="protein sequence ID" value="ABB33751"/>
        <property type="gene ID" value="Gmet_3546"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3546"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949163_0_0_7"/>
    <dbReference type="OMA" id="THEKEAY"/>
    <dbReference type="OrthoDB" id="1677662at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="293" mass="30183" checksum="C75C0A2232886869" modified="2005-11-22" version="1">MKHLLFRCLGIPIVITTFFVSVGSETPAAASPAGKKKTESTEVAASSPAKPALAYAEYVRLVSRRGVAGRGHAKKKPAKAAKVTRTAKKADQKVVSAKAEPTPVVPVRTVAPVVAVEPKRGGGWRPGPAEVREVLGTTRDLSGANLRGMNLAGLDLRNASLANADLYLANLAGACLDGANLRGTSLEMANLRGASLKGAKLSGAGLFMTNLEGADLERADLTGVYAVGANLRGAALASANLRGGLFTNAVMARSVAVLTEDGEGRGGGTVTKATARDDAARPDPAERLTFLKF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PU1</accession>
    <name>SYS_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA synthetase</fullName>
            <shortName evidence="1">SerRS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Seryl-tRNA(Ser/Sec) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">serS</name>
        <name type="ordered locus">Gmet_3528</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Ser) = AMP + diphosphate + H(+) + L-seryl-tRNA(Ser)</text>
            <dbReference type="Rhea" id="RHEA:12292"/>
            <dbReference type="Rhea" id="RHEA-COMP:9669"/>
            <dbReference type="Rhea" id="RHEA-COMP:9703"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-serine + tRNA(Sec) = AMP + diphosphate + H(+) + L-seryl-tRNA(Sec)</text>
            <dbReference type="Rhea" id="RHEA:42580"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:10128"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; L-seryl-tRNA(Sec) from L-serine and tRNA(Sec): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer. The tRNA molecule binds across the dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513684.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39PU1"/>
    <dbReference type="SMR" id="Q39PU1"/>
    <dbReference type="STRING" id="269799.Gmet_3528"/>
    <dbReference type="EnsemblBacteria" id="ABB33733">
        <property type="protein sequence ID" value="ABB33733"/>
        <property type="gene ID" value="Gmet_3528"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3528"/>
    <dbReference type="eggNOG" id="COG0172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023797_1_1_7"/>
    <dbReference type="OMA" id="SPCFRRE"/>
    <dbReference type="OrthoDB" id="353391at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016260">
        <property type="term" value="P:selenocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00176">
        <property type="entry name" value="Ser_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43697">
        <property type="entry name" value="PTHR43697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="SSF46589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000019687" description="Serine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="229"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="260"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="347"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00176"/>
        </source>
    </evidence>
    <sequence length="423" mass="47866" checksum="0E3A1BC5273CA196" modified="2005-11-22" version="1">MLDPKHLRENFESVEQRLATRGGAVTLDRFRELDSRRRELLREAESLKAVRNAASEEISRIKDKSQAQPRIAEMREVSAKIKVLDDDLRGVDDDLQAVLLTIPNIPHQSVPVGASEADNREVRKWGEPPRFGFTPRPHWEIGEGLGILDFERGAKLTGARFTLYRGAGARLERALINFMLDLHTEKHGYEETLPPFMVNRESMTGTGQLPKFEEDLFHLDGTDYYLIPTAEVPVTNIHRGEILKGSDLPLSYTAYTPCFRKEAGSYGKDVRGLIRQHQFNKVELVKFTHPSTSYAELERLLANAEEVLRQLGLHYRVVELCTGDMGFSAAKTYDIEVWLPAQDTYREISSCSNFEDFQARRASIRFREDDKAKPEFAHTLNGSGLAVGRTLVAILENYQQEDGTVVIPEVLRPYMGGCSSIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PU5</accession>
    <name>Q39PU5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-specific adenosine deaminase</fullName>
            <ecNumber evidence="3">3.5.4.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3 6" type="primary">tadA</name>
        <name evidence="6" type="ordered locus">Gmet_3524</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosine(34) in tRNA + H(+) + H2O = inosine(34) in tRNA + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:43168"/>
            <dbReference type="Rhea" id="RHEA-COMP:10373"/>
            <dbReference type="Rhea" id="RHEA-COMP:10374"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:82852"/>
            <dbReference type="EC" id="3.5.4.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="3">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.33" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513681.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3524"/>
    <dbReference type="EnsemblBacteria" id="ABB33729">
        <property type="protein sequence ID" value="ABB33729"/>
        <property type="gene ID" value="Gmet_3524"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3524"/>
    <dbReference type="eggNOG" id="COG0590">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025810_3_2_7"/>
    <dbReference type="OMA" id="PCQMCAG"/>
    <dbReference type="OrthoDB" id="1890883at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00972">
        <property type="entry name" value="tRNA_aden_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028883">
        <property type="entry name" value="tRNA_aden_deaminase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14437">
        <property type="entry name" value="MafB19-deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="SSF53927"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="5">
        <location>
            <begin position="10"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="171" mass="18978" checksum="71AD3D18C6FEC7CC" modified="2005-11-22" version="1">MVRRKAEGVRDDSYWMGKALREAEKAAARDEVPIGAVVVRNGAVIGRGHNLRENKQDPSAHAEMIAIRQAARRLGCWRLTGCVLYVTLEPCLMCMGAIILARFDRVVFGCHDPKGGAAGSLYDLSDDRRLNHRVELTSRVREEECSAILSGFFADLRTRKKKARRAPSAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q34</accession>
    <name>Q39Q34_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heterodisulfide oxidoreductase, iron-sulfur cluster-binding subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hdrD</name>
        <name evidence="5" type="ordered locus">Gmet_3428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514235.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3428"/>
    <dbReference type="EnsemblBacteria" id="ABB33640">
        <property type="protein sequence ID" value="ABB33640"/>
        <property type="gene ID" value="Gmet_3428"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3428"/>
    <dbReference type="eggNOG" id="COG0479">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1035">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063409_0_0_7"/>
    <dbReference type="OMA" id="CAPTMFG"/>
    <dbReference type="OrthoDB" id="1072875at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="238"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="305" mass="33475" checksum="C5D7953A674585AC" modified="2005-11-22" version="1">MNTTAQQLDTTAIAPAVYATITDAICREAEKALESGAVAAVVGWQAGRRQGTAMPAIVTTPADTDKLIFSPACVNNLALYLSKAKKEIRARGKIAIVVKGCDLKALVGLMGENQLKRADIHVIGVVCPGVRGTSEPLAKKCRECTVHTPEGADVTVGTLPELPHFTPAESEELARLEAMTPAERWSFWKEHFARCIRCYACRQVCPFCYCEQCLCDRNRPQAVETTPRPAGNMAWHIVRAMHLAGRCAGCAECERACPMDIPLNLLNRKMAKELKELYGHEAGFEVKEKGPLAEYRENDDQSFIK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-04-14" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q52</accession>
    <name>ATPF_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(0) sector subunit b</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ATPase subunit I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit b</fullName>
            <shortName evidence="1">F-ATPase subunit b</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpF</name>
        <name type="ordered locus">Gmet_3410</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase B chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514217.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Q52"/>
    <dbReference type="SMR" id="Q39Q52"/>
    <dbReference type="STRING" id="269799.Gmet_3410"/>
    <dbReference type="EnsemblBacteria" id="ABB33622">
        <property type="protein sequence ID" value="ABB33622"/>
        <property type="gene ID" value="Gmet_3410"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3410"/>
    <dbReference type="eggNOG" id="COG0711">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079215_3_2_7"/>
    <dbReference type="OMA" id="NILNWAV"/>
    <dbReference type="OrthoDB" id="1530385at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045263">
        <property type="term" value="C:proton-transporting ATP synthase complex, coupling factor F(o)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01398">
        <property type="entry name" value="ATP_synth_b_bprime"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002146">
        <property type="entry name" value="ATP_synth_b/b'su_bac/chlpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00430">
        <property type="entry name" value="ATP-synt_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0138">CF(0)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000368502" description="ATP synthase subunit b">
        <location>
            <begin position="1"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01398"/>
        </source>
    </evidence>
    <sequence length="206" mass="22576" checksum="D3E368F94DA35B69" modified="2005-11-22" version="1">MANACKKKRLLKSVMMPAAVCAAVIGLSALGFAAEGGEGAHHVDTGKQMKDFMWRVIDFAALLGVIIWALKKANAKGALADRTANIEKALREAEEARAAAEKKFAEYSGKLEKANLEIDDIYAAIRKEAELEKERIIAEAKLTADKIREQAAATASQEVLKAKAELRGEAARLAVQMAEQSLRENIKKDDQDRLVNDYLTKVENLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q82</accession>
    <name>Q39Q82_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-dihydroxy-6-naphtoate synthase</fullName>
            <ecNumber evidence="3">4.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Menaquinone biosynthetic enzyme MqnD</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3 4" type="primary">mqnD</name>
        <name evidence="4" type="ordered locus">Gmet_3380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 3">Quinol/quinone metabolism; menaquinone biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MqnA/MqnD family. MqnD subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.-.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512606.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3380"/>
    <dbReference type="EnsemblBacteria" id="ABB33592">
        <property type="protein sequence ID" value="ABB33592"/>
        <property type="gene ID" value="Gmet_3380"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3380"/>
    <dbReference type="eggNOG" id="COG2107">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070326_0_0_7"/>
    <dbReference type="OMA" id="RGCGPLV"/>
    <dbReference type="OrthoDB" id="1107067at2"/>
    <dbReference type="UniPathway" id="UPA00079"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00996">
        <property type="entry name" value="MqnD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003773">
        <property type="entry name" value="Menaquinone_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030869">
        <property type="entry name" value="MqnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37167">
        <property type="entry name" value="PTHR37167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02621">
        <property type="entry name" value="VitK2_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="60"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="3">
        <location>
            <begin position="114"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="281" mass="30063" checksum="7BA225EFEE32EBB9" modified="2005-11-22" version="1">MTTDTVPLTLGFSPCPNDTYIFHALVHGLVDTGGLTFRERLEDVETLNRLALEGALDVSKVSYHALGFLRDEYVLLRSGGALGRGCGPLVVTRGAASMAELRGKPVAVPGRYTTAVLLLRLFDPSLDNLVYLPFHEIMGAVARGEVAAGVIIHESRFTFPEYGLSKLLDLGEWWEGETGCPIPLGGIVARRSLGREAVAAIDRALRASVVHARTNPGAAAGYIRAHSQEMSDEVCAAHIDLYVNDFSLQLGPEGEGAVATLLQRAEASGVIPRSTAPLFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QJ4</accession>
    <name>Q39QJ4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chemotaxis protein methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cheR64H</name>
        <name evidence="8" type="ordered locus">Gmet_3267</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512704.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3267"/>
    <dbReference type="EnsemblBacteria" id="ABB33480">
        <property type="protein sequence ID" value="ABB33480"/>
        <property type="gene ID" value="Gmet_3267"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3267"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_0_1_7"/>
    <dbReference type="OMA" id="CELGIYD"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026024">
        <property type="entry name" value="Chemotaxis_MeTrfase_CheR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000410">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="7">
        <location>
            <begin position="1"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="202"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000410-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="277" mass="32018" checksum="E0882D717D937D4A" modified="2005-11-22" version="1">MTLSDKDFEVLRDFIYNHCGIYFHTSKKYFLESRITRRIEATSSPNLMTYMGLLKSGPGKSDELLKLLTEITTNETCFFRNPPQLKALENVFLPEIVAAKGKIGFRKLRIWSAGSSSGEEAYTMAMLLLEKRATILKDWIIEIVGTDISETVLAQAREGVYNAYSVRNTPDYYKKKYFRQEPGERYVLSPDVKKLVSFNHLNLYEDAKMVFMKSFDFIFCANVLIYFDLASKTKVVQHYYNNLQPYGYFFVGQSESLHGVNDKFKTVHFPGGFAYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QQ3</accession>
    <name>Q39QQ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane lipoprotein carrier/sorting protein LolA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512646.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3208"/>
    <dbReference type="EnsemblBacteria" id="ABB33421">
        <property type="protein sequence ID" value="ABB33421"/>
        <property type="gene ID" value="Gmet_3208"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3208"/>
    <dbReference type="eggNOG" id="COG2834">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087560_2_2_7"/>
    <dbReference type="OMA" id="FFQRSTI"/>
    <dbReference type="OrthoDB" id="1933827at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd16325">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029046">
        <property type="entry name" value="LolA/LolB/LppX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004564">
        <property type="entry name" value="OM_lipoprot_carrier_LolA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35869">
        <property type="entry name" value="PTHR35869"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03548">
        <property type="entry name" value="LolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89392">
        <property type="entry name" value="SSF89392"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223155" evidence="2">
        <location>
            <begin position="24"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="272" mass="30579" checksum="E212A589056BF028" modified="2005-11-22" version="1">MKIYRLVIVVFLALFVGAVPATAAPVARVNAGLQDVIDTVEKSFRPDRNTGLPPLATVTADFFQRSTIAGKEREMRADGQMYFKTASSREPLMFRFDYFRPLKQEIVSDGRTLWMYLPENRQVIVSDVTPVFNPFTFNPDRDRASNFLQGLPRISKDFLIVFSPQGQDIAGNYVLELTPRRATAAIAKLFIVVPREAVLSYVQSGRTSVNTISNIGRQEWPFPILSTTMEDHQGSTTLMEFSNVRTNIMLSDSLFSFAVPPGVQVVKPPRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QV1</accession>
    <name>Q39QV1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FliK domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513876.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3160"/>
    <dbReference type="EnsemblBacteria" id="ABB33373">
        <property type="protein sequence ID" value="ABB33373"/>
        <property type="gene ID" value="Gmet_3160"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3160"/>
    <dbReference type="eggNOG" id="COG3144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033226_0_0_7"/>
    <dbReference type="OMA" id="HGEVMAN"/>
    <dbReference type="OrthoDB" id="1681930at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021136">
        <property type="entry name" value="Flagellar_hook_control-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02120">
        <property type="entry name" value="Flg_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_hook" evidence="2">
        <location>
            <begin position="499"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="572" mass="58942" checksum="DF8E4D590C855176" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R72</accession>
    <name>Q39R72_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3037</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514351.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3037"/>
    <dbReference type="EnsemblBacteria" id="ABB33252">
        <property type="protein sequence ID" value="ABB33252"/>
        <property type="gene ID" value="Gmet_3037"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3037"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="QVHKYYG"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="41"/>
            <end position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="241" mass="25681" checksum="43CA7A4524120248" modified="2005-11-22" version="1">MGEVVKITDVTKVYTMGDQRVEALKGISFTVSQGEFVAIMGASGSGKSTCMNMLGCLDVPTSGEYLLEGVNVGGLSRNELAEIRNTKIGFVFQGFNLLARTTARENVELPLVYAHVSAAARRERALAALERVGLAGRADHYSNQLSGGQQQRVAIARALVNEPAIIMADEPTGNLDSRTTVEIMAIFQELNRHGITILMVTHEPDVAAFTGRHLVFRDGTIIADSPNASPAVASPAQGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R78</accession>
    <name>Q39R78_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sodium/solute symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">aplD</name>
        <name evidence="8" type="ordered locus">Gmet_3031</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514345.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3031"/>
    <dbReference type="EnsemblBacteria" id="ABB33246">
        <property type="protein sequence ID" value="ABB33246"/>
        <property type="gene ID" value="Gmet_3031"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3031"/>
    <dbReference type="eggNOG" id="COG4147">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018808_8_2_7"/>
    <dbReference type="OMA" id="GTTWVQM"/>
    <dbReference type="OrthoDB" id="278483at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019899">
        <property type="entry name" value="Na/solute_symporter_VC_2705"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03648">
        <property type="entry name" value="Na_symport_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="509" mass="54261" checksum="0237EFD436FED92E" modified="2005-11-22" version="1">MTDAGPNLIPLIIVTLALASFIVAGLRARARSASDYGIGGRYIGRIGGGAAIASNWMSAASLLGMGGLLYLHGYYALAYVIGWTGGYVLLLVLMAGQIRRFGKYTAPDFVGDRYASPMAGLISAGISITISIIYCTAQFKGIGMLFGWLFGTGYRNGVILGAVVVVGYVIISGVLGVARNQQLQYTLLIVSFILPLMVLAYKLGYFWVLPQFGYGVAIQDLKREFGINFAAPFASGSLFQWISLCFTLMVGTAGLPHVLSRFYVVPNIRDARWSLVWGLFFIALIYWSAPAYAVFARLLEARAGMTLPPAAAEKMADLIVIRTAVMGGLPPWMIGILAAGAVSAAFFTVAGLLITGASSFSHDIYYRFINPRASETTKMALSKAAVVALAVVVLVIAMDPPGLIAEITAVAFALAGNTIFPAFLLGIWWGRANRHGVIAGMLTGVVITFSTPLFGRFLPVVADIFPLTSSAFFGAPAVIAVMVAVSLLTPPPPEEVRRFLAEQVHGHMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R90</accession>
    <name>Q39R90_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methylamine utilization protein MauE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_3019</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be specifically involved in the processing, transport, and/or maturation of the MADH beta-subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">One-carbon metabolism; methylamine degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514333.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3019"/>
    <dbReference type="EnsemblBacteria" id="ABB33234">
        <property type="protein sequence ID" value="ABB33234"/>
        <property type="gene ID" value="Gmet_3019"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3019"/>
    <dbReference type="eggNOG" id="COG2259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_101331_3_1_7"/>
    <dbReference type="OMA" id="DCGCFAP"/>
    <dbReference type="OrthoDB" id="1721242at2"/>
    <dbReference type="UniPathway" id="UPA00895"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030416">
        <property type="term" value="P:methylamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009908">
        <property type="entry name" value="Methylamine_util_MauE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07291">
        <property type="entry name" value="MauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="MauE" evidence="11">
        <location>
            <begin position="10"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="138" mass="14859" checksum="43ADBB35D33F0E63" modified="2005-11-22" version="1">MEPVKKHLTAVLRVGLGALFLYAGVIKIITPAAFAGSIANYQVLPYAGNYLVAAILPWVEVICGALLVTGWRARSAAALVACMNAFFIVLLFSTVVRGLDIDCGCFKQGGEKTTAWTAIFRDTMLLVAAVFVYRRGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RF1</accession>
    <name>Q39RF1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512891.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2956"/>
    <dbReference type="EnsemblBacteria" id="ABB33173">
        <property type="protein sequence ID" value="ABB33173"/>
        <property type="gene ID" value="Gmet_2956"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2956"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_358941_0_0_7"/>
    <dbReference type="OMA" id="ENHHGFI"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="569"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="780" mass="87037" checksum="7500ACEA060AFD96" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RI2</accession>
    <name>Q39RI2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_2924</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512860.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2924"/>
    <dbReference type="EnsemblBacteria" id="ABB33142">
        <property type="protein sequence ID" value="ABB33142"/>
        <property type="gene ID" value="Gmet_2924"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2924"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="QLLSHDW"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="5"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="144"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="470" mass="52689" checksum="3A32757D574EECF5" modified="2005-11-22" version="1">MENIDVLVVDDEAVIREGLRRILEKEGFHVETSASGQIALERMQEENFSLVITDLKMPGMSGMEVLKAIKVLQPEVPVIIITGFSTVDTAVEAMKNGAFDYIAKPFTPEQITEKVRKALDQRAVLIENIFLKKELGEHHGFDLFVGESKEIQKVYRRIIQVAPTDSTVLITGESGTGKELVARAIHNHSNRRENPFVAVDCTSLAENLLESELFGHVKGSFTGAIQTKTGLFKVADGGTLFLDEISNISLTTQAKLLRVLQEREITPIGGTQPVPIDIRLVAATNKNLRTLVPQGTFREDLFFRLNIIPIDLPPLRERKGDLPLLIAFFLKKFSEEMGREIRGLAPDAMALLEDYTFPGNVRELENIIERAVVLAEEDLIQKEDLELRLSGSEGTGVAAYVPQNVEELKETKRQIRERAVEPIEKAFVLQALKRNNWNITRAAEETGMLRPNFQALLKKLRISVRSQMNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RQ6</accession>
    <name>Q39RQ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Polysaccharide deacetylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514566.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2850"/>
    <dbReference type="EnsemblBacteria" id="ABB33068">
        <property type="protein sequence ID" value="ABB33068"/>
        <property type="gene ID" value="Gmet_2850"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2850"/>
    <dbReference type="eggNOG" id="COG0726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021264_4_0_7"/>
    <dbReference type="OMA" id="HINQPTH"/>
    <dbReference type="OrthoDB" id="1701876at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="SSF88713"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223305" evidence="1">
        <location>
            <begin position="22"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="70"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="271" mass="28987" checksum="DABBA1A81AC5F988" modified="2005-11-22" version="1">MKLLFFWVAAALMLGAGAGSAEVSAPLHESAGNGYASLREGLVTRFDGRTPKEWGETVTGVKTRLAGGDKSIALTFDACGSPRGKGFDAPLIDFLERERIPATLFVSGLWIDANPVLFRRLVANPLFEIANHGYRHRPASVAGQKAYGIAGTRTVGDVVDEIELNARRIEETTGKRPAFYRSGTAYYDEVAVEIAAALGERVAGYSLLGDAGATFSSQQVRAALLKARPGDIALLHMNHPESGTAAGVMAAIPELRKRGFRFVKLSDVPVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RQ7</accession>
    <name>ISPE_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">4-diphosphocytidyl-2-C-methyl-D-erythritol kinase</fullName>
            <shortName evidence="1">CMK</shortName>
            <ecNumber evidence="1">2.7.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispE</name>
        <name type="ordered locus">Gmet_2849</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57823"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.148"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GHMP kinase family. IspE subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.148" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514567.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RQ7"/>
    <dbReference type="SMR" id="Q39RQ7"/>
    <dbReference type="STRING" id="269799.Gmet_2849"/>
    <dbReference type="EnsemblBacteria" id="ABB33067">
        <property type="protein sequence ID" value="ABB33067"/>
        <property type="gene ID" value="Gmet_2849"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2849"/>
    <dbReference type="eggNOG" id="COG1947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053057_1_1_7"/>
    <dbReference type="OMA" id="RWPSPAK"/>
    <dbReference type="OrthoDB" id="1938933at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00094"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050515">
        <property type="term" value="F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00061">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004424">
        <property type="entry name" value="IspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43527:SF2">
        <property type="entry name" value="PTHR43527:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010376">
        <property type="entry name" value="IspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="SSF55060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00154">
        <property type="entry name" value="ispE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000235095" description="4-diphosphocytidyl-2-C-methyl-D-erythritol kinase">
        <location>
            <begin position="1"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00061"/>
        </source>
    </evidence>
    <sequence length="281" mass="29758" checksum="7302923A753BE517" modified="2005-11-22" version="1">MKSLTLKAPAKVNYRLDVLRRRPDGYHDLRMIMQRIDLCDEITITLSDTSGVRVTCGREGVPDGPENIAWRAANALLALSGLETGIDIAITKNIPVAAGLGGGSSDAATVLLGVNELLGLGLSIERLMEVGVTLGADVPFFVFGKTALAEGIGEVLTAIDAVPPLWLVIVNPNIPVSTAWVYQSLRLTGEWNGDTIPRFFKDVADVCAVLANDLELVTIERYPVIGEIKERLVAAGAAGALMSGSGPTVFGLFASEEEARGAAQSITNSSDWFVVAVRALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RS7</accession>
    <name>Q39RS7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DUF748 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366109.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2829"/>
    <dbReference type="EnsemblBacteria" id="ABB33047">
        <property type="protein sequence ID" value="ABB33047"/>
        <property type="gene ID" value="Gmet_2829"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2829"/>
    <dbReference type="eggNOG" id="COG2982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005680_1_0_7"/>
    <dbReference type="OMA" id="QQPPAEW"/>
    <dbReference type="OrthoDB" id="167445at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008023">
        <property type="entry name" value="DUF748"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05359">
        <property type="entry name" value="DUF748"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="758"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1200" mass="128905" checksum="AA7FC30478554E5C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RX6</accession>
    <name>Q39RX6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511681.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2780"/>
    <dbReference type="EnsemblBacteria" id="ABB32998">
        <property type="protein sequence ID" value="ABB32998"/>
        <property type="gene ID" value="Gmet_2780"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2780"/>
    <dbReference type="eggNOG" id="COG4980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105320_5_1_7"/>
    <dbReference type="OMA" id="DIGTGTM"/>
    <dbReference type="OrthoDB" id="1935138at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036629">
        <property type="entry name" value="YjbJ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024623">
        <property type="entry name" value="YtxH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12732">
        <property type="entry name" value="YtxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69047">
        <property type="entry name" value="SSF69047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="104" mass="11274" checksum="37772D65E3CFC55E" modified="2005-11-22" version="1">MADEEKGISVGTVFLSFLAGTAVGAGLGLLLAPKTGKEMRENIMDLTDDAIDKIKGFTKEAQGKIKDTYEETKDLIAEKKSIITSAIEAGKEAMDREKEKYGQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S08</accession>
    <name>Q39S08_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2748</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511711.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2748"/>
    <dbReference type="EnsemblBacteria" id="ABB32966">
        <property type="protein sequence ID" value="ABB32966"/>
        <property type="gene ID" value="Gmet_2748"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2748"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_443289_0_0_7"/>
    <dbReference type="OMA" id="CREINDE"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="391"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="616" mass="67998" checksum="1B84E21C7EE93EAB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S53</accession>
    <name>Q39S53_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Phosphate transport system permease protein PstA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pstA</name>
        <name evidence="9" type="ordered locus">Gmet_2703</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2703"/>
    <dbReference type="EnsemblBacteria" id="ABB32921">
        <property type="protein sequence ID" value="ABB32921"/>
        <property type="gene ID" value="Gmet_2703"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2703"/>
    <dbReference type="eggNOG" id="COG0581">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033621_2_0_7"/>
    <dbReference type="OMA" id="GIARWKA"/>
    <dbReference type="OrthoDB" id="1763210at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:inorganic phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005672">
        <property type="entry name" value="Phosphate_PstA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00974">
        <property type="entry name" value="3a0107s02c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="8">
        <location>
            <begin position="67"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="279" mass="29631" checksum="5776E57843B716A2" modified="2005-11-22" version="1">MNIVTRRNLKNSIITISMVCATVAVLVPLGLIFFHIMKMGASSINLDFFIHIPKPTGETGGGMANGMVGSALLIALASTIGIPVGVFGALYLVEFGGSRISNTVRFAADVLSGVPSIITGMVAYTLLVVPMKGFSALAGAVALSLIMVPIVLRTTEEQLKMVPGSLREASLALGVPLWRTSLKVTLRSATKGVMTGILLAIARIAGETAPLLFTALGNQFWSKKLTEPIAAMPLQIFNFAIAPYEDWHKLAWAGALVLVTIMFGLSLTARYLGRSRQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SA8</accession>
    <name>Q39SA8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2648</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511814.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2648"/>
    <dbReference type="EnsemblBacteria" id="ABB32866">
        <property type="protein sequence ID" value="ABB32866"/>
        <property type="gene ID" value="Gmet_2648"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2648"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2506802_0_0_7"/>
    <dbReference type="OMA" id="TNIYHIP"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="86" mass="9503" checksum="7EB1FB60638D6315" modified="2005-11-22" version="1">MELEQIKQGLVSNVYHLTADKKGALHKHPDHDEIFYCIKGEGVGVLERGEIELSVGKVFIVPAGVMHTVRSSDEIYVASFLVPVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SB2</accession>
    <name>Q39SB2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 8">2-dehydropantoate 2-reductase</fullName>
            <ecNumber evidence="4 8">1.1.1.169</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Ketopantoate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">panE</name>
        <name evidence="11" type="ordered locus">Gmet_2643</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2009-05" db="PDB data bank">
            <title>Crystal structure of 2-dehydropantoate 2-reductase FROM Geobacter metallireducens.</title>
            <authorList>
                <person name="Patskovsky Y."/>
                <person name="Toro R."/>
                <person name="Morano C."/>
                <person name="Rutter M."/>
                <person name="Chang S."/>
                <person name="Sauder J.M."/>
                <person name="Burley S.K."/>
                <person name="Almo S.C."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2-302</scope>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:16233"/>
            <dbReference type="ChEBI" id="CHEBI:11561"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.169"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.169" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511818.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="3HN2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B/C/D=2-302"/>
    </dbReference>
    <dbReference type="PDBsum" id="3HN2"/>
    <dbReference type="SMR" id="Q39SB2"/>
    <dbReference type="STRING" id="269799.Gmet_2643"/>
    <dbReference type="EnsemblBacteria" id="ABB32862">
        <property type="protein sequence ID" value="ABB32862"/>
        <property type="gene ID" value="Gmet_2643"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2643"/>
    <dbReference type="eggNOG" id="COG1893">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031468_6_1_7"/>
    <dbReference type="OMA" id="NLGYHSG"/>
    <dbReference type="OrthoDB" id="427052at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00004"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q39SB2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003710">
        <property type="entry name" value="ApbA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00745">
        <property type="entry name" value="apbA_panE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="8" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 8" id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ApbA" evidence="9">
        <location>
            <begin position="3"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="ApbA_C" evidence="10">
        <location>
            <begin position="176"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="3HN2"/>
        </source>
    </evidence>
    <sequence length="302" mass="33101" checksum="E2E91015CFFA1B29" modified="2005-11-22" version="1">MRIAIVGAGALGLYYGALLQRSGEDVHFLLRRDYEAIAGNGLKVFSINGDFTLPHVKGYRAPEEIGPMDLVLVGLKTFANSRYEELIRPLVEEGTQILTLQNGLGNEEALATLFGAERIIGGVAFLCSNRGEPGEVHHLGAGRIILGEFLPRDTGRIEELAAMFRQAGVDCRTTDDLKRARWEKLVWNIPFNGLCALLQQPVNLILARDVSRKLVRGIMLEVIAGANAQGLATFIADGYVDDMLEFTDAMGEYKPSMEIDREEGRPLEIAAIFRTPLAYGAREGIAMPRVEMLATLLEQATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SC5</accession>
    <name>Q39SC5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366077.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2630"/>
    <dbReference type="EnsemblBacteria" id="ABB32849">
        <property type="protein sequence ID" value="ABB32849"/>
        <property type="gene ID" value="Gmet_2630"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2630"/>
    <dbReference type="eggNOG" id="COG0488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_36_0_7"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="OrthoDB" id="1112046at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="320"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="545" mass="61023" checksum="BDDEFF1613E951A3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SI0</accession>
    <name>Q39SI0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513459.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32794">
        <property type="protein sequence ID" value="ABB32794"/>
        <property type="gene ID" value="Gmet_2575"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2575"/>
    <dbReference type="eggNOG" id="ENOG5033DN4">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2934945_0_0_7"/>
    <dbReference type="OMA" id="MLITKTW"/>
    <dbReference type="OrthoDB" id="2062702at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="60" mass="6654" checksum="EFF763DC7C4D8D9E" modified="2005-11-22" version="1">MSMDKIWYTLDEAAAKFGVPSARILSWVEDGLVRSEDEGGKIVRVNGDDLELKVEELTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SJ3</accession>
    <name>Q39SJ3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gnfL</name>
        <name evidence="7" type="ordered locus">Gmet_2562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513472.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2562"/>
    <dbReference type="EnsemblBacteria" id="ABB32781">
        <property type="protein sequence ID" value="ABB32781"/>
        <property type="gene ID" value="Gmet_2562"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2562"/>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_7"/>
    <dbReference type="OMA" id="EIMLTTA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="7"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="79"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="144"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="363" mass="39582" checksum="18858F47D6BB8C49" modified="2005-11-22" version="1">MSPESPNEAFLATIIDSVGDGVIVIDLGGRITLMNPAAEEIIAISRRQAMGHPFAALLGSQEILVDMVAKTAATGMTISDNENIVIRKAKQLTPVAVTTFPLLRQDGEPIGTILMLRDLTNIRELEDAVRHADRLSTLGTLAAGLAHEIKNPLGGIKGAAQLLEMELPPESELRDNVRVVVREVDRVNRIVEELLALSSPRKLQLTKVNLHKILGDIVTLRKRATEGKSVTFQQQFDPSIPPILADEGLLTQLFLNLIKNAVEAVDERGTIRVASRVLSDYSMTPKGERRSRMVAVDVRDDGPGIPREQLEQLFTPFFTTKAKGTGLGLAICQKIVTEHRGMLKVESDPGTGTTFTVMLPLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ST2</accession>
    <name>Q39ST2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512433.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2467"/>
    <dbReference type="EnsemblBacteria" id="ABB32692">
        <property type="protein sequence ID" value="ABB32692"/>
        <property type="gene ID" value="Gmet_2467"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2467"/>
    <dbReference type="eggNOG" id="ENOG5033B0D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1265439_0_0_7"/>
    <dbReference type="OMA" id="GIAWQND"/>
    <dbReference type="OrthoDB" id="2077410at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="218" mass="22697" checksum="F20D9424D6CA62E2" modified="2005-11-22" version="1">MSLILDALRKMEQERKARQGGGIDIRPDVLGHTRIESAGRSWGSKPFILVAAGIVLLAAGVGTGIVLKKGTEGEKPEQSRSVDRNRPLPVEEVTSVTVPSPPPLTPTPTEAPPAAIPAKPAAPPAPVAAPAPAPKPVQRSVAAEQPAPSEYPGANLTVSGIAWQEERSLRRAVVNGNLVGEGAEVAGARVVEIGERRVKFSQGGRTISVSLSSPFQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ST3</accession>
    <name>Q39ST3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidoglycan-binding ATPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">exeA</name>
        <name evidence="3" type="ordered locus">Gmet_2466</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512434.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2466"/>
    <dbReference type="EnsemblBacteria" id="ABB32691">
        <property type="protein sequence ID" value="ABB32691"/>
        <property type="gene ID" value="Gmet_2466"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2466"/>
    <dbReference type="eggNOG" id="COG3267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3271">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3409">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024125_2_1_7"/>
    <dbReference type="OMA" id="LINGVCD"/>
    <dbReference type="OrthoDB" id="947558at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.101.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005074">
        <property type="entry name" value="Peptidase_C39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002477">
        <property type="entry name" value="Peptidoglycan-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036365">
        <property type="entry name" value="PGBD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036366">
        <property type="entry name" value="PGBDSf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01471">
        <property type="entry name" value="PG_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47090">
        <property type="entry name" value="SSF47090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50990">
        <property type="entry name" value="PEPTIDASE_C39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C39" evidence="2">
        <location>
            <begin position="323"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="562" mass="60337" checksum="EC6A95AE68DD6052" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SU3</accession>
    <name>Q39SU3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366056.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2456"/>
    <dbReference type="EnsemblBacteria" id="ABB32681">
        <property type="protein sequence ID" value="ABB32681"/>
        <property type="gene ID" value="Gmet_2456"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2456"/>
    <dbReference type="eggNOG" id="COG0398">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038944_7_0_7"/>
    <dbReference type="OMA" id="CIKIPRD"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="SNARE_assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="SNARE_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="224" mass="23966" checksum="50AE7428D96D764D" modified="2005-11-22" version="1">MTRPKLVAIAVIGLAVALFFMSGLDRHLTLQSLKANRELLVSYSEQHRLAAVSLFIGIYVVQTALSLPGAAILSLAAGAIFGAVQGTVYAVIGATLGATLAFLVTRYLFHDAVQEKFGHRLTTINRELETAGLNYLLFLRLVPLFPFFLINLAAGLTHLPLRTFIIGTLVGIIPGGFVYVNAGASLATISNPADAASPRVLGSFALLGLFALIPVIYRKFTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SV1</accession>
    <name>Q39SV1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Major royal jelly-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2448</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512451.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2448"/>
    <dbReference type="EnsemblBacteria" id="ABB32673">
        <property type="protein sequence ID" value="ABB32673"/>
        <property type="gene ID" value="Gmet_2448"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2448"/>
    <dbReference type="eggNOG" id="COG3386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031076_0_3_7"/>
    <dbReference type="OMA" id="KGRMWVL"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017996">
        <property type="entry name" value="Royal_jelly/protein_yellow"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10009">
        <property type="entry name" value="PTHR10009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03022">
        <property type="entry name" value="MRJP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="390" mass="43270" checksum="0DDFA00EBF3173A1" modified="2005-11-22" version="1">MPKQTGNARNPFVLLALFILVCSGGCATYPISHDKAVPVARGALFEYPYFHDQVTGIAVSGQGRIFVNFPRWDKDPLYSVAEVLPDGSLRPYPDHGWNRWGADETAHPEAHFICVQSVFVDHSDFLWILDPASPAFNGVVPGGAKLVKVNLKTDQVERVIPFAPSAAPHESYLNDVRIDPEGNFAFITDSGKGAIVVVDLESGKARRLLSGHPSTKAEPGYVPVIEGKELRNEDGTVPKIHADGIALDSRGEYLYYHALVGRTLYRIRTSFLKDPSLPEKDLENHVERIAETGAADGMLMDAQDNLYLTALEENAVKRYRPSEPTLNTIIQGGLHWPDSLAISPDNYLYVTDSQINLAPRFNHGKDLRIIPYKFFKTWLMPFSHDGLLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SX5</accession>
    <name>Q39SX5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Methyl-accepting chemotaxis sensory transducer, class 34H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">mcp34H-6</name>
        <name evidence="8" type="ordered locus">Gmet_2424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512476.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2424"/>
    <dbReference type="EnsemblBacteria" id="ABB32649">
        <property type="protein sequence ID" value="ABB32649"/>
        <property type="gene ID" value="Gmet_2424"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2424"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3850">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_16_7"/>
    <dbReference type="OMA" id="QLTESIN"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="7">
        <location>
            <begin position="230"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="6">
        <location>
            <begin position="287"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="293"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="549"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="473"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="581" mass="62160" checksum="B64B9B63646E86DE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T47</accession>
    <name>Q39T47_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-N-acetylglucosamine 3-dehydrogenase, NAD-dependent</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">gnnA</name>
        <name evidence="3" type="ordered locus">Gmet_2352</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513268.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2352"/>
    <dbReference type="EnsemblBacteria" id="ABB32577">
        <property type="protein sequence ID" value="ABB32577"/>
        <property type="gene ID" value="Gmet_2352"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2352"/>
    <dbReference type="eggNOG" id="COG0673">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023194_10_0_7"/>
    <dbReference type="OMA" id="GWHHARV"/>
    <dbReference type="OrthoDB" id="1465613at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GFO_IDH_MocA" evidence="1">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="GFO_IDH_MocA_C" evidence="2">
        <location>
            <begin position="159"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="310" mass="34049" checksum="064FC36FB5749FAB" modified="2005-11-22" version="1">MTEKIRTAVIGVGYLGLFHAEKFAQLPESDLIGVVDTSRPRAEEVAAKVGTAPYTDYRELLDKVDAVSIVVPTQFHFEVARAFLERGVHVLLEKPVTTTVEEADELIRLAEDNGVVFQVGHLERFNPVIVGLKGLLTGPRFIESIRIAPFKPRGTDVNVVLDLMIHDIDIIQTIVGSPVKQISSIGAPVFTDEEDIANARIQFENGCVANVTASRISLKSERKMRIFQADSYISVDFQNKKLAVFRKGSGEMLPGVPKVDMEEKSFDQGDALKSEIASFLECVRTGAKPVVSGQDGKRALETAIKISKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T98</accession>
    <name>Q39T98_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514497.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2301"/>
    <dbReference type="EnsemblBacteria" id="ABB32526">
        <property type="protein sequence ID" value="ABB32526"/>
        <property type="gene ID" value="Gmet_2301"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2301"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_389209_0_0_7"/>
    <dbReference type="OMA" id="YEVMKPG"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026352">
        <property type="entry name" value="Nanowire_3heme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039118">
        <property type="entry name" value="QrcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39425">
        <property type="entry name" value="PTHR39425"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04257">
        <property type="entry name" value="nanowire_3heme"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome_C7" evidence="1">
        <location>
            <begin position="37"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="1">
        <location>
            <begin position="113"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="1">
        <location>
            <begin position="188"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="1">
        <location>
            <begin position="264"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="1">
        <location>
            <begin position="339"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="1">
        <location>
            <begin position="414"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="1">
        <location>
            <begin position="491"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="1">
        <location>
            <begin position="564"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="1">
        <location>
            <begin position="642"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="709" mass="75961" checksum="A563D94BEFE7E694" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TQ3</accession>
    <name>Q39TQ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA--carboxylate coenzyme A transferase and acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513063.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2142"/>
    <dbReference type="EnsemblBacteria" id="ABB32371">
        <property type="protein sequence ID" value="ABB32371"/>
        <property type="gene ID" value="Gmet_2142"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2142"/>
    <dbReference type="eggNOG" id="COG0427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030703_1_0_7"/>
    <dbReference type="OMA" id="CGEPQYL"/>
    <dbReference type="OrthoDB" id="319106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="462"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="617" mass="69150" checksum="4B612461E4DDC9C2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TU1</accession>
    <name>Q39TU1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phenylphosphate synthase, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2104</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513100.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2104"/>
    <dbReference type="EnsemblBacteria" id="ABB32333">
        <property type="protein sequence ID" value="ABB32333"/>
        <property type="gene ID" value="Gmet_2104"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2104"/>
    <dbReference type="eggNOG" id="COG0517">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_9_1_7"/>
    <dbReference type="OMA" id="QFPVMEN"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="7"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="81"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="146" mass="16549" checksum="0C0FAE1EE543250E" modified="2005-11-22" version="1">MIVRNWMQNNPLTISSDTLASEAKRLLLDNNLNALLVVDNGRLRGLVTRHNVMRMGHYVTRTQNPDEVSFFVNRLKVRDFMVRNPATVDANDTMEHCLEYGKELMVAQFPVMENGSVVGIISANEIFQLAAHLCGTMEAEKMRKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TU5</accession>
    <name>Q39TU5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phenylphosphate synthase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365917.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2100"/>
    <dbReference type="EnsemblBacteria" id="ABB32329">
        <property type="protein sequence ID" value="ABB32329"/>
        <property type="gene ID" value="Gmet_2100"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2100"/>
    <dbReference type="eggNOG" id="COG3848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031538_0_0_7"/>
    <dbReference type="OMA" id="AIVCREY"/>
    <dbReference type="OrthoDB" id="997616at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016772">
        <property type="term" value="F:transferase activity, transferring phosphorus-containing groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-utilizers" evidence="1">
        <location>
            <begin position="533"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="609" mass="69976" checksum="C34128B481EFC52D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-06-16" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TZ3</accession>
    <name>MIAA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Dimethylallyl diphosphate:tRNA dimethylallyltransferase</fullName>
            <shortName evidence="1">DMAPP:tRNA dimethylallyltransferase</shortName>
            <shortName evidence="1">DMATase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Isopentenyl-diphosphate:tRNA isopentenyltransferase</fullName>
            <shortName evidence="1">IPP transferase</shortName>
            <shortName evidence="1">IPPT</shortName>
            <shortName evidence="1">IPTase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">miaA</name>
        <name type="ordered locus">Gmet_2052</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = diphosphate + N(6)-dimethylallyladenosine(37) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IPP transferase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514052.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39TZ3"/>
    <dbReference type="SMR" id="Q39TZ3"/>
    <dbReference type="STRING" id="269799.Gmet_2052"/>
    <dbReference type="EnsemblBacteria" id="ABB32281">
        <property type="protein sequence ID" value="ABB32281"/>
        <property type="gene ID" value="Gmet_2052"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2052"/>
    <dbReference type="eggNOG" id="COG0324">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032616_0_1_7"/>
    <dbReference type="OMA" id="YAKRQYT"/>
    <dbReference type="OrthoDB" id="1069591at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="PTHR11088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <feature type="chain" id="PRO_0000377171" description="tRNA dimethylallyltransferase">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <begin position="39"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with substrate tRNA" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00185"/>
        </source>
    </evidence>
    <sequence length="309" mass="34822" checksum="237F71A5DB3DEBF5" modified="2005-11-22" version="1">MKEEEKTRLVIVQGPTASGKSALALELAERIGGEIVNADSMQVYRGMDIGTAKPSQEERRRVPHHLYDIVDPKVNFTAADFREHASRAIADIERRGKRVILVGGTGLYIRILTQGLVASPGGDDNIRRELEDQAHGEGLESLHRRLAAVDPVAAARLHPNDGVRIVRALEVFLLTGRPLSAFQEAHRFADEPYRCLKLGITVERELLYRRVEERVDRMIAEGLVEEVRGLLSAGYPATLKAMGSIGYREICAHLAGEFSLDEAMRLIKQNTRQYAKRQMTWFRRDSEIIWVEYPGKFDSILSTVMGFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U36</accession>
    <name>Q39U36_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lipid A core--O antigen ligase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2009</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512941.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2009"/>
    <dbReference type="EnsemblBacteria" id="ABB32238">
        <property type="protein sequence ID" value="ABB32238"/>
        <property type="gene ID" value="Gmet_2009"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2009"/>
    <dbReference type="eggNOG" id="COG3307">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_583848_0_0_7"/>
    <dbReference type="OMA" id="DTHNFYL"/>
    <dbReference type="OrthoDB" id="1077328at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007016">
        <property type="entry name" value="O-antigen_ligase-related"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04932">
        <property type="entry name" value="Wzy_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="198"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="356"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="385"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="459" mass="51505" checksum="1359E33CC5716F7A" modified="2005-11-22" version="1">MLGLGLSEIVPYVVYGLAGPVIIASAVNRSAIGLLFLVPLIPLYVILDKVLKSELPLANNVIDFTIIAMLLGICIQKRDDEVPALGPSPLLKPLAIFAGYSFISLLIGSASFDGLTGEINLLRLAHWKNYMIMPLLYLITYYALRERAWQNKLFTFLFGAFLVADIRFQQSFKWVKHTRYQGSKSRVSGLANLGPNEMGAFHAIHMLFVLGLFIIDKNVKRRIAYVFFMIGSTYCALYSYSRGAYVAILLTAIFIAFVKERRLLIVIVAFLITWKAILPSSVVDRIENTIVEDGARTDVVEVGGMQLETAKRTEIWEKALGYFYENPITGKGYNTYQYLTGWDTHNVYIKFMAEEGVIGLSLYIWLYVLALRSGWKLYKNGDEEIIKAFGFGFVCAVIASIVSNFFGDRWTYLQLGGIYWVLWALVDQHNARIAASVTDVVAVPAAPEMDHFPNSRIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U51</accession>
    <name>Q39U51_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">UDP-N-acetyl-D-galactosamine 6-dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">capL</name>
        <name evidence="5" type="ordered locus">Gmet_1994</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512956.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1994"/>
    <dbReference type="EnsemblBacteria" id="ABB32223">
        <property type="protein sequence ID" value="ABB32223"/>
        <property type="gene ID" value="Gmet_1994"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1994"/>
    <dbReference type="eggNOG" id="COG0677">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023810_3_1_7"/>
    <dbReference type="OMA" id="GHCLPID"/>
    <dbReference type="OrthoDB" id="295459at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016628">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028359">
        <property type="entry name" value="UDP_ManNAc/GlcNAc_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500136">
        <property type="entry name" value="UDP_ManNAc_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="SSF52413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDPG_MGDP_dh_C" evidence="4">
        <location>
            <begin position="316"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="429" mass="46403" checksum="1D1B6DF6B3E24602" modified="2005-11-22" version="1">MNSLNRTVSVVGLGYVGLPVAVAFGKVRKTVGFDINPVRIRELKEGHDRTGEVETEDLKAADILFTDSIDELKQADFHIVAVPTPVDEANQPDLTLMLKASETVGKALEKGDIVVYESTVYPGVTEDECVPVLERVSGLKSGSDFTVGYSPERINPGDKEHTFTKIKKVVAGQDAATLETVAQVYESVVTAGVHRAASIKVAEAAKVIENTQRDLNIALMNELAIIFGRLGIDTNDVLEAAGTKWNFLKFRPGLVGGHCIGVDPYYLTHKAEKIGYIPQVILAGRRINDGMGKYIAQQAVKGMIHAGHCVRGCTVTVLGLTFKEDCPDLRNSKVIDIIRELEDYGVEVQVHDPLADAGEASHEYGVRLVPFGELRPAAAVVAAVAHRDYRELSVEGVKGLMGDGPVLVDVKGIYDPAAVRAAGIRLWRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U92</accession>
    <name>Q39U92_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1953</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglycosylase Slt family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511891.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1953"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32182">
        <property type="protein sequence ID" value="ABB32182"/>
        <property type="gene ID" value="Gmet_1953"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1953"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065765_1_1_7"/>
    <dbReference type="OMA" id="MQVIPDT"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008933">
        <property type="term" value="F:lytic transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000270">
        <property type="term" value="P:peptidoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025392">
        <property type="entry name" value="DUF4124"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000189">
        <property type="entry name" value="Transglyc_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13511">
        <property type="entry name" value="DUF4124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00922">
        <property type="entry name" value="TRANSGLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4124" evidence="3">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="SLT" evidence="2">
        <location>
            <begin position="82"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="203" mass="22951" checksum="E8AC9514DC3EEADC" modified="2005-11-22" version="1">MPKVASILALALLLLGGVGYFDANADIYRYEDEEGVVHFTDAPTDKRFKIFMRDIKRDRKLRTTFKLARFTRDPAEFEPIITQCAQEFGVDRSLVKAVIHAESGYNPNAVSPKGASGLMQLMPKTARDLKVANSLDPRENIRGGVRYLRFLLDTFRGDESLALAAYNAGLSRVAQYNGIPPYQETRTYVDRVLTYRKSYQTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U93</accession>
    <name>Q39U93_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">pgsA-1</name>
        <name evidence="13" type="ordered locus">Gmet_1952</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="10">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511892.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1952"/>
    <dbReference type="EnsemblBacteria" id="ABB32181">
        <property type="protein sequence ID" value="ABB32181"/>
        <property type="gene ID" value="Gmet_1952"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1952"/>
    <dbReference type="eggNOG" id="COG0558">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051314_2_2_7"/>
    <dbReference type="OMA" id="WSMVYYL"/>
    <dbReference type="OrthoDB" id="1702107at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004570">
        <property type="entry name" value="Phosphatidylglycerol_P_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000847">
        <property type="entry name" value="Phos_ph_gly_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00560">
        <property type="entry name" value="pgsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="197" mass="22009" checksum="B8FE415E04157392" modified="2005-11-22" version="1">MPDTNAKTIWNIPNILTLLRIALIPVLAVLLLSPSREAGFWAAAVFAVASTTDWLDGYLARRMGIVTVFGKFLDPIADKLMVMAALIMILPYNRVPAWMVLVILGREIIITGLRGIASSEGIVISASDLGKFKTIFQMVAIIGLLLHYDYHWFFGVDNPYLIVNMHNAGMFYLWIATIMTVWSGADYLAKFMRVIAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UA7</accession>
    <name>Q39UA7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Orotate phosphoribosyltransferase</fullName>
            <shortName evidence="4">OPRT</shortName>
            <shortName evidence="4">OPRTase</shortName>
            <ecNumber evidence="2 4">2.4.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">pyrE</name>
        <name evidence="6" type="ordered locus">Gmet_1938</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>diphosphate + orotidine 5'-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + orotate</text>
            <dbReference type="Rhea" id="RHEA:10380"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57538"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="EC" id="2.4.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.10" evidence="2 4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511905.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1938"/>
    <dbReference type="EnsemblBacteria" id="ABB32167">
        <property type="protein sequence ID" value="ABB32167"/>
        <property type="gene ID" value="Gmet_1938"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1938"/>
    <dbReference type="eggNOG" id="COG0461">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074878_2_1_7"/>
    <dbReference type="OMA" id="YVNCKPV"/>
    <dbReference type="OrthoDB" id="1280396at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00119"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004588">
        <property type="term" value="F:orotate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01208">
        <property type="entry name" value="PyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023031">
        <property type="entry name" value="OPRT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004467">
        <property type="entry name" value="Or_phspho_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00336">
        <property type="entry name" value="pyrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 4" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran" evidence="5">
        <location>
            <begin position="47"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="5-phosphoribose 1-diphosphate binding" evidence="4">
        <location>
            <begin position="124"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>5-phospho-alpha-D-ribose 1-diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>orotate</name>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="182" mass="19819" checksum="2AB9DA3053604FCF" modified="2005-11-22" version="1">MTDRERLKQIIIELSYEKRKVTLASGRESDFYFDGKQTTLHAEGGLLVGKLFYEAIKDVENVQGVGGITLGADPIATATSIAAFLDGRPMHAFIIRKEPKGHGTGQWLEGRKNLPPGARVVIVEDVVTTGGSSMKAVRRAEEEGLVVLGIVALVDREEGGRENIEAEGVWLRSIFTKSQLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UE1</accession>
    <name>Q39UE1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sulfate ABC transporter, membrane protein CysW</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cysW</name>
        <name evidence="11" type="ordered locus">Gmet_1904</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511940.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1904"/>
    <dbReference type="EnsemblBacteria" id="ABB32133">
        <property type="protein sequence ID" value="ABB32133"/>
        <property type="gene ID" value="Gmet_1904"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1904"/>
    <dbReference type="eggNOG" id="COG4208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016047_14_0_7"/>
    <dbReference type="OMA" id="NEYNFVA"/>
    <dbReference type="OrthoDB" id="1110665at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011866">
        <property type="entry name" value="CysW_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005667">
        <property type="entry name" value="Sulph_transpt2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406">
        <property type="entry name" value="PTHR30406"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30406:SF1">
        <property type="entry name" value="PTHR30406:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00969">
        <property type="entry name" value="3a0106s02"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02140">
        <property type="entry name" value="permease_CysW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="64"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="278" mass="30149" checksum="88C5A68E192ACAED" modified="2005-11-22" version="1">MSSISAKSARTEPALVRWLLIVTAFLFLGLFLFVPLAAVFVQALEKGWGAYLSAIREPDALAAVKLTLVTAAVSVPVNLVFGVVAAWAIAKFEFRGKQLLITLIDLPFSVSPVISGLIYVLLFGLQGWLGPWLQAHDLKIIFAVPGIVLATVFVTFPFVARELIPLMEAQGKDEEEAAITLGASGFQAFWRVTIPNIKWGLLYGVILCNARAMGEFGAVSVVSGHIRGATNTIPLHVEILYNEYNYVAAFAVASLLALLALVTLVAKSFVEWRMRESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UI1</accession>
    <name>Q39UI1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type II secretion system ATPase PulE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pulE</name>
        <name evidence="3" type="ordered locus">Gmet_1864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511982.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1864"/>
    <dbReference type="EnsemblBacteria" id="ABB32093">
        <property type="protein sequence ID" value="ABB32093"/>
        <property type="gene ID" value="Gmet_1864"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1864"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_10_6_7"/>
    <dbReference type="OMA" id="EINHGVD"/>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T2SP_E" evidence="2">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="573" mass="64046" checksum="F221F7ED28C66A3D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UL5</accession>
    <name>Q39UL5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512015.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1830"/>
    <dbReference type="EnsemblBacteria" id="ABB32059">
        <property type="protein sequence ID" value="ABB32059"/>
        <property type="gene ID" value="Gmet_1830"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1830"/>
    <dbReference type="HOGENOM" id="CLU_1298304_0_0_7"/>
    <dbReference type="OMA" id="YEKSSFY"/>
    <dbReference type="OrthoDB" id="1411404at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223525" evidence="1">
        <location>
            <begin position="22"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="212" mass="23629" checksum="D2EF26262F34430D" modified="2005-11-22" version="1">MRTLVLSFLCGALFLAGCSLKVVPQQVPQGVINTADNSQTITNDGIAITAANSDREMVSYNLDGTVTAFDVSIHNRTDREVGFGVDSFVLLDDQNRQHLPLTPERVKEIVSRDSYYLIPYPYVGFYYLEDYERTSSYTETGSQLPYYYEVYPQDIFTRALNAATVIPGATAEGLVYFRIDLAAIKGMKLLVFRKGASKSAPPDFTFPFVISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UU5</accession>
    <name>Q39UU5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1748</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513356.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1748"/>
    <dbReference type="EnsemblBacteria" id="ABB31979">
        <property type="protein sequence ID" value="ABB31979"/>
        <property type="gene ID" value="Gmet_1748"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1748"/>
    <dbReference type="HOGENOM" id="CLU_1935037_0_0_7"/>
    <dbReference type="OMA" id="VNRIAFA"/>
    <dbReference type="OrthoDB" id="1645596at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="14482" checksum="11D37E9B0A0CE233" modified="2005-11-22" version="1">MGAKEITVVFYRQNHMRDNWKVDLDGVEAERFFGKLEGDLSRAGVVLKRSRNEAFTIDINSYADLLNAVRISSPADGFGSVCIGHIIGQSQNLDIMDDIRRAVMRIAFAPETVPPEDHNRKVCHNCGCGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UY1</accession>
    <name>Q39UY1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">etfA-7</name>
        <name evidence="7" type="ordered locus">Gmet_1712</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514142.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1712"/>
    <dbReference type="EnsemblBacteria" id="ABB31943">
        <property type="protein sequence ID" value="ABB31943"/>
        <property type="gene ID" value="Gmet_1712"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1712"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_7"/>
    <dbReference type="OMA" id="VAGEGCQ"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="6">
        <location>
            <begin position="3"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="304" mass="31984" checksum="EC97B07233AAB063" modified="2005-11-22" version="1">MKALLVCEYREGKLLDTTYELLAFADRIGAEKAMVLIGSDSALPACNSTVYLAEAAKYGEYNPDVHKKIVLDAVQRENADCIVFVHSSYGWDLAPRVAAALRAGQVSEIVGVVDGGYEVGCCNAKMRRAVTPTSGKAVLTVQAGAFSFTGTPQGTPKVERIDIPDGATPVEFVGYEPAEKKDVDLTRAEVIVSAGRGVGKKDNIPVIQALAKALGGELGASRPVVDAGWVDHSHQVGTTGQSVSPKLYVACGISGAIQHLAGMKKSDFVVAINKDKDAPIGEVADVLVVADVMQFVPALTAKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UY2</accession>
    <name>Q39UY2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA--carboxylate coenzyme A transferase, family III</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514143.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1711"/>
    <dbReference type="EnsemblBacteria" id="ABB31942">
        <property type="protein sequence ID" value="ABB31942"/>
        <property type="gene ID" value="Gmet_1711"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1711"/>
    <dbReference type="eggNOG" id="COG1804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033975_5_1_7"/>
    <dbReference type="OMA" id="GYRVYPC"/>
    <dbReference type="OrthoDB" id="969868at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="SSF89796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="281" mass="30554" checksum="53C011BB40797FC3" modified="2005-11-22" version="1">MKPLKGMVVVNLAVNLPGPAAARRLRHLGASVVKVEPPSGDLMELYNADWYRDMAVGQTVVRIDLKSAEGLAHLNGLLATADLLITASRPAGLCRLGLGWEELHRKFPRLCQVAIVGYPAPRENEAGHDLTYQASLGLLNPPHMPRTLLADMAGAEQTVSAAMALLLIRERGQEAGYAEVALSRAAEAMAEPLRYGSTAPGALLGGGIPEYNLYEARDGWVALAALEPHFKSRLEESLGVSTREEYRAAFADRSAREWQEWGREQDIPIIVAEEKKPCISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V02</accession>
    <name>Q39V02_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Malonyl-CoA--acyl carrier protein transacylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fabD-1</name>
        <name evidence="3" type="ordered locus">Gmet_1691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31922.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514163.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1691"/>
    <dbReference type="EnsemblBacteria" id="ABB31922">
        <property type="protein sequence ID" value="ABB31922"/>
        <property type="gene ID" value="Gmet_1691"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1691"/>
    <dbReference type="eggNOG" id="COG0331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030558_4_1_7"/>
    <dbReference type="OMA" id="QHPGMFD"/>
    <dbReference type="OrthoDB" id="1123553at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="SSF52151"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="SSF55048"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS_AT" evidence="2">
        <location>
            <begin position="5"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31922.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="280" mass="30631" checksum="E9745BB0C5DCA04C" modified="2012-10-31" version="2">MICFMFPGQPLTFETTVPDDPDFRQATALTLDRTGLDLADSALLGEGLTEHVRLQVYGVAMSLYRCRRLRREGTVPAIIAEHSMGIYPAMAACGALDDGDALELTCRIGACIAAMGTRRSYALGCVTGLTAAPLMAVAENNGVFLANYNTSRHFLLSGERRNVEDAVAEALNNGAFTARSFPCDAPLHSPLMEEVAGELREVIGDYRFREPVLPLMSHIDQDYLSAADLPEFLVRELSLPVYWERTFQALSDAGVSRFVEVGVGDSLKKYNRWIASEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V48</accession>
    <name>Q39V48_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent hydrolase, subgroup D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511419.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1645"/>
    <dbReference type="DNASU" id="3740414"/>
    <dbReference type="EnsemblBacteria" id="ABB31876">
        <property type="protein sequence ID" value="ABB31876"/>
        <property type="gene ID" value="Gmet_1645"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1645"/>
    <dbReference type="eggNOG" id="COG0402">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012358_2_5_7"/>
    <dbReference type="OMA" id="CNEKCEV"/>
    <dbReference type="OrthoDB" id="1592010at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="SSF51338"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="1">
        <location>
            <begin position="54"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="421" mass="45734" checksum="C391050518E99E30" modified="2005-11-22" version="1">MELYAASYILPIASPPIPGGAVAVHDGCIVETGTLAELRSRHSGPVHDFPGCAILPGLVNAHTHLELTHFPSWKIRKGIDYSPRTYVDWIIQVIKIRRALSPQELELSVREGLRICLEAGTTAIGEILTDRSLIPLYADSGLRGRLLFEAIGHDPVRNAQLVEELDAAIASFSGGSFLPGISPHAPHTVAEHLHQDVYRLAYERNVPRVIHLAESREESDFFFDSSGKIAEFLYPHVRWESYLPAPRRTTATAWLDGLGVLNGTISAVHCVHLTPSDAEILAKRGVGVVLCPRSNDKLAVGRAPVVLLKRLGVPLALGTDSLASNDSLSLWDEMRYLLDTFPGIFTPTEALSMTTIGSARQLALADRTGSLDKGKHADFLVMKLPGRNGSGEALHEALIHSGEILQVFLAGNLVVSREAFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V53</accession>
    <name>Q39V53_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="12">ATP-PFK</shortName>
            <shortName evidence="12">Phosphofructokinase</shortName>
            <ecNumber evidence="12">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pfk-1</name>
        <name evidence="12" type="synonym">pfkA</name>
        <name evidence="14" type="ordered locus">Gmet_1640</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer or homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511424.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1640"/>
    <dbReference type="EnsemblBacteria" id="ABB31871">
        <property type="protein sequence ID" value="ABB31871"/>
        <property type="gene ID" value="Gmet_1640"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1640"/>
    <dbReference type="eggNOG" id="COG0205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020655_0_0_7"/>
    <dbReference type="OMA" id="CAYPVDP"/>
    <dbReference type="OrthoDB" id="1421302at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01976">
        <property type="entry name" value="Phosphofructokinase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012003">
        <property type="entry name" value="ATP_PFK_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012829">
        <property type="entry name" value="Phosphofructokinase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000532">
        <property type="entry name" value="ATP_PFK_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="SSF53784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02483">
        <property type="entry name" value="PFK_mixed"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="9 12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PFK" evidence="13">
        <location>
            <begin position="4"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="139"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="183"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="12">
        <location>
            <begin position="286"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="76"/>
            <end position="77"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="116"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="280"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="12">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB31871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="363" mass="38953" checksum="9D74199410784CA8" modified="2005-11-22" version="1">MKRKIGILTGGGDCPGLNAVIRGVVKSAIIGRGWEVVGIEDGFDGLLYDRTPRPLGLEDVRGILPRGGTILGTSNRGNPFSYPIEVNGKTVLTDVSDRVVERVKDLGIDAIVAVGGDGSLKIALELMKRGVPVVGVPKTIDNDLMETDVTFGYNTALETATDALDKLHSTAESHHRIMIMEVMGRYAGWIALESGISGGADVILIPEIPFELKAVCNAIEGRRRRGSKFSIVVAAEGAFPRGGTRVVQKKADETMAIERLGGIGNFVAHELTSCLDMDIRVTVLGHLQRGGSPSTFDRCLGSRFGIGAVELIEREQYGEMICLKGRAIRSVPIEKAVRKLKLVDPRGQMVTAAKELGINVGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V59</accession>
    <name>Q39V59_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transglutaminase/protease-like domain membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1634</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511430.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1634"/>
    <dbReference type="EnsemblBacteria" id="ABB31865">
        <property type="protein sequence ID" value="ABB31865"/>
        <property type="gene ID" value="Gmet_1634"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1634"/>
    <dbReference type="eggNOG" id="COG1305">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012397_2_1_7"/>
    <dbReference type="OMA" id="VTEDMAH"/>
    <dbReference type="OrthoDB" id="670657at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021878">
        <property type="entry name" value="TgpA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11992">
        <property type="entry name" value="TgpA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="SSF54001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="TGc" evidence="2">
        <location>
            <begin position="400"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="644" mass="71564" checksum="0521CDD3E6FE79AE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V76</accession>
    <name>Q39V76_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365852.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1617"/>
    <dbReference type="EnsemblBacteria" id="ABB31848">
        <property type="protein sequence ID" value="ABB31848"/>
        <property type="gene ID" value="Gmet_1617"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1617"/>
    <dbReference type="HOGENOM" id="CLU_2105459_0_0_7"/>
    <dbReference type="OMA" id="VITSFAW"/>
    <dbReference type="OrthoDB" id="2001798at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="115" mass="12643" checksum="B28217BC996DE71E" modified="2005-11-22" version="1">MKSLLLLLPAVLAVVGCSPVRGQLSDWQGARLDELMGQAGPPSSVSADMAGNKYYHWLEDRGGVYTYNGPVNLKCERIFGVDEREVITSFAWDGNCLALPDSPWQRISQSRQGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VL2</accession>
    <name>Q39VL2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GH3 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1478"/>
    <dbReference type="EnsemblBacteria" id="ABB31712">
        <property type="protein sequence ID" value="ABB31712"/>
        <property type="gene ID" value="Gmet_1478"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1478"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016249_4_0_7"/>
    <dbReference type="OMA" id="TNCIEDW"/>
    <dbReference type="OrthoDB" id="566369at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004993">
        <property type="entry name" value="GH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31901">
        <property type="entry name" value="PTHR31901"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03321">
        <property type="entry name" value="GH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="527" mass="59867" checksum="D5BCE8F96125EE5B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W31</accession>
    <name>Q39W31_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoacid:ferredoxin oxidoreductase, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">vorA</name>
        <name evidence="3" type="ordered locus">Gmet_1307</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512059.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1307"/>
    <dbReference type="EnsemblBacteria" id="ABB31543">
        <property type="protein sequence ID" value="ABB31543"/>
        <property type="gene ID" value="Gmet_1307"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1307"/>
    <dbReference type="eggNOG" id="COG0674">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017038_0_0_7"/>
    <dbReference type="OMA" id="EAAINMV"/>
    <dbReference type="OrthoDB" id="360732at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR_N" evidence="1">
        <location>
            <begin position="16"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="PFOR_II" evidence="2">
        <location>
            <begin position="247"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="352" mass="38353" checksum="774580ED492CB2AA" modified="2005-11-22" version="1">MTKRLFMKGNEALAMAAIEAGCRYYFGYPITPQSDIPEYMSRELPKLGGEFIQAESEVASINMLLGASATGVRAMTSSSSPGISLKQEGISYMAGAELPGVIVNICRSGPGLGGIDASQADYFQAVKGGGHGGYHIIVLAPASVQEMYDLTMLAFDLADLYRMPSMILGDSVVGQMKESVIPNKRPERNLPPKDWVVRGKGDGEQRVVKSLYLGDGELEAHNWKLHARYGELKAKEARWEEFMLDDAELVVTAFGSAARIAKSAVMAARDKGLKVGLLRPITLYPFPEKAFLAATERCKKVLDIELNAGQMVEDVRLSVARDAEVFFYGRPPGAGSLPTPEELLEQITNYYV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W61</accession>
    <name>KDSA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-dehydro-3-deoxyphosphooctonate aldolase</fullName>
            <ecNumber evidence="1">2.5.1.55</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">3-deoxy-D-manno-octulosonic acid 8-phosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">KDO-8-phosphate synthase</fullName>
            <shortName evidence="1">KDO 8-P synthase</shortName>
            <shortName evidence="1">KDOPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phospho-2-dehydro-3-deoxyoctonate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kdsA</name>
        <name type="ordered locus">Gmet_1277</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-arabinose 5-phosphate + H2O + phosphoenolpyruvate = 3-deoxy-alpha-D-manno-2-octulosonate-8-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14053"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57693"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:85985"/>
            <dbReference type="EC" id="2.5.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate biosynthesis; 3-deoxy-D-manno-octulosonate biosynthesis; 3-deoxy-D-manno-octulosonate from D-ribulose 5-phosphate: step 2/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the KdsA family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.55" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512090.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W61"/>
    <dbReference type="SMR" id="Q39W61"/>
    <dbReference type="STRING" id="269799.Gmet_1277"/>
    <dbReference type="EnsemblBacteria" id="ABB31513">
        <property type="protein sequence ID" value="ABB31513"/>
        <property type="gene ID" value="Gmet_1277"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1277"/>
    <dbReference type="eggNOG" id="COG2877">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036666_0_0_7"/>
    <dbReference type="OMA" id="FRGIPTM"/>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="UniPathway" id="UPA00030"/>
    <dbReference type="UniPathway" id="UPA00357">
        <property type="reaction ID" value="UER00474"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008676">
        <property type="term" value="F:3-deoxy-8-phosphooctulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019294">
        <property type="term" value="P:keto-3-deoxy-D-manno-octulosonic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00056">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006269">
        <property type="entry name" value="KDO8P_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21057">
        <property type="entry name" value="PTHR21057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01362">
        <property type="entry name" value="KDO8P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0448">Lipopolysaccharide biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000304451" description="2-dehydro-3-deoxyphosphooctonate aldolase">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00056"/>
        </source>
    </evidence>
    <sequence length="272" mass="29275" checksum="17B4DCDF1EF05387" modified="2005-11-22" version="1">MTREIAIGNVKMGGSRPLVLIAGPCVIENETATLRCAERLMTIVNGLSIPLIFKASYDKANRTSVTAFRGPGLKEGLRILAKVKESLGLPVISDIHSIEQVQPAAEVLDILQIPAFLCRQTDLLVEAARTGCVVNVKKGQFLAPWDMENVVGKIVASGNERIILTERGASFGYNNLVSDMRSLPIMRRFGFPVVFDATHSVQLPGGQGGSSGGQREFVEYLSRAAVATGIDGVFLEVHEEPDKALCDGPNSVPLDDLPVLLKKLKAIDAIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W84</accession>
    <name>Q39W84_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isoprenyl transferase</fullName>
            <ecNumber evidence="2">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">uppS</name>
        <name evidence="3" type="ordered locus">Gmet_1254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="2">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512113.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1254"/>
    <dbReference type="EnsemblBacteria" id="ABB31490">
        <property type="protein sequence ID" value="ABB31490"/>
        <property type="gene ID" value="Gmet_1254"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1254"/>
    <dbReference type="eggNOG" id="COG0020">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038505_1_1_7"/>
    <dbReference type="OMA" id="PRTEGHK"/>
    <dbReference type="OrthoDB" id="1630604at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="PTHR10291"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="SSF64005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="19"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="2">
        <location>
            <begin position="192"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="active site" evidence="2">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="246" mass="28253" checksum="AE91E47ADF15813A" modified="2005-11-22" version="1">MYGLSHDKLPRHLAVIMDGNGRWAQERMLKRIIGHQKGVETVRVIVEECSRLGIKYLTLFAFSAENWLRPKTEVKALMSLLKKYIRVETARMLDSNIRFNVIGAREELPPDVNQAVQEAIDRTARNTGMVLTLALSYGARQEILLAAERIAADLSSGHLSLGDIDEKTFSSYLFTSGMPDPDFLIRTSGEMRISNFLLWQLAYTELYFTEVNWPEFTAKELHRALHDYQSRERRFGRTSAQLQNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WG3</accession>
    <name>Q39WG3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1173</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513439.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1173"/>
    <dbReference type="EnsemblBacteria" id="ABB31411">
        <property type="protein sequence ID" value="ABB31411"/>
        <property type="gene ID" value="Gmet_1173"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1173"/>
    <dbReference type="eggNOG" id="COG2982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287263_0_0_7"/>
    <dbReference type="OMA" id="DMVSGGM"/>
    <dbReference type="OrthoDB" id="696993at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007844">
        <property type="entry name" value="AsmA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032712">
        <property type="entry name" value="AsmA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05170">
        <property type="entry name" value="AsmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13502">
        <property type="entry name" value="AsmA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA" evidence="2">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="AsmA_2" evidence="3">
        <location>
            <begin position="813"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1079" mass="117605" checksum="2F0B11211B9229CF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WQ2</accession>
    <name>Q39WQ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1082</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513738.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1082"/>
    <dbReference type="EnsemblBacteria" id="ABB31322">
        <property type="protein sequence ID" value="ABB31322"/>
        <property type="gene ID" value="Gmet_1082"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1082"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="LQEQEYY"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="8"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="153"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="472" mass="51669" checksum="0A9A36439C032F64" modified="2005-11-22" version="1">MPDQQTFPILVVDDEEEILFTTSITLRSAGFPPVLTESDSRNVMGILARQEVALVLLDLYMPHLPGYELLKEITANHPEIPVIVVTAANEVGMAVECMKAGAFDYFVKPMEPPRLLATVRRALEMHSLRSQVNSLSSHILTGGLDNEEAFAPIITRSRKMHSIFQYLEAIAPSNQPLLITGETGVGKELIARTVHNISGCRGPFVAVNIAGLDDMVFSDTLFGHLKGAFTGADRQREGLIAKAAGGTLFLDEIGDLQPSSQVKLLRLLQEQEYYPLGADTPVHAAARVVVATNRDLKAIMADGSFRKDLYYRLSAHQVLIPPLRDRREDIPLLVDHFFDEAAASLSRQKPTIPPELACYLGTYAFPGNIRELRAMVFDAMARHEKGVLSLAGFREVIGNPRSPAETSPLPFIEGLREESGNAGRMPTLKEAEDALIAHALSIANGNQGIASAHLGITRQALNKRLNRKTADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WQ7</accession>
    <name>Q39WQ7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chemotaxis protein methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cheR36H</name>
        <name evidence="8" type="ordered locus">Gmet_1077</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513733.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1077"/>
    <dbReference type="EnsemblBacteria" id="ABB31317">
        <property type="protein sequence ID" value="ABB31317"/>
        <property type="gene ID" value="Gmet_1077"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1077"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_0_0_7"/>
    <dbReference type="OMA" id="EWQEFVN"/>
    <dbReference type="OrthoDB" id="1378151at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008983">
        <property type="term" value="F:protein-glutamate O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026024">
        <property type="entry name" value="Chemotaxis_MeTrfase_CheR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000410">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="217"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="6">
        <location>
            <begin position="235"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000410-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="300" mass="34374" checksum="7D8BC88A3ED4FB4A" modified="2005-11-22" version="1">MPNHDIAPLTGTDADFPPRDLREFRFTDGDFARVRELIYRTAGIALSPVKRDLVYGRLARRLRVRGLTSFDDYLRIVESGDRQEREAFVNALTTNLTSFFREPHHFPILADHLKGLGGRRQLSIWCCAASTGEEPYSIAMTVVEQFGTFTPPVRILATDIDTSVLDRARQGIYRLDRIERLPREQVRRFFLRGDGKNAGLARVRPEAQKIITFRQLNLLDPQWPMRERFDAIFCRNVMIYFDKETQYGILKKFVPLLHPGGLLFAGHSESFHHAADLFQVRGKTVYAVRDGAPLPTGLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WR4</accession>
    <name>Q39WR4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CRISPR-associated exonuclease Cas4</fullName>
            <ecNumber evidence="6">3.1.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">cas4</name>
        <name evidence="8" type="ordered locus">Gmet_1070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="6">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="6">Mg(2+) or Mn(2+) required for ssDNA cleavage activity.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>iron-sulfur cluster</name>
            <dbReference type="ChEBI" id="CHEBI:30408"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the CRISPR-associated exonuclease Cas4 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.12.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513726.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1070"/>
    <dbReference type="EnsemblBacteria" id="ABB31310">
        <property type="protein sequence ID" value="ABB31310"/>
        <property type="gene ID" value="Gmet_1070"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1070"/>
    <dbReference type="eggNOG" id="COG1468">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102055_1_1_7"/>
    <dbReference type="OMA" id="QQWVWSD"/>
    <dbReference type="OrthoDB" id="1594787at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013343">
        <property type="entry name" value="CRISPR-assoc_prot_Cas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022765">
        <property type="entry name" value="Dna2/Cas4_DUF83"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01930">
        <property type="entry name" value="Cas_Cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00372">
        <property type="entry name" value="cas4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="6 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cas_Cas4" evidence="7">
        <location>
            <begin position="11"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="204" mass="23326" checksum="8E4A624084204062" modified="2005-11-22" version="1">MNEPTDPIMISALEHYSYCPRQCALIHVEQVWGENLYTMRGRDVHENVDMESSHDVAGIRYERALPLWSKRLNLIGKADLVEFHGETPYPVEYKSGRHRDGRHEALQLCAQAICLEEMFGVAVEKGALFWHGSRERREVVFTDVIREHVEKAAEGVFALIAQSTVPPPVNDKRCTHCSLKESCLPAVVAEKDRSRRVARELFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WU8</accession>
    <name>Q39WU8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Molybdenum cofactor biosynthesis protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">moaB</name>
        <name evidence="7" type="ordered locus">Gmet_1036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May be involved in the biosynthesis of molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MoaB/Mog family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513209.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1036"/>
    <dbReference type="EnsemblBacteria" id="ABB31276">
        <property type="protein sequence ID" value="ABB31276"/>
        <property type="gene ID" value="Gmet_1036"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1036"/>
    <dbReference type="eggNOG" id="COG0521">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077358_1_1_7"/>
    <dbReference type="OMA" id="CGVAGQT"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00886">
        <property type="entry name" value="MogA_MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012245">
        <property type="entry name" value="MoaB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008284">
        <property type="entry name" value="MoCF_biosynth_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006443">
        <property type="entry name" value="MoaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01078">
        <property type="entry name" value="MOCF_BIOSYNTHESIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="6">
        <location>
            <begin position="4"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="163" mass="17308" checksum="AB9931C227E80F0A" modified="2005-11-22" version="1">MRAAILTLSDKGSRGERADASGPALSAWLAERGVETAHTEIIPDEADLITATLSQWADSGLYDLILTTGGTGVSPRDVTPDATMKVLDRVIPGFGEVMRMRSLEKTPHAMISRAVAGIRKQALIINLPGSPRGAIENLEAVWPAVPHAVEKIQGDTRDCAPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="53" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WV9</accession>
    <name>Q39WV9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513195.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1024"/>
    <dbReference type="EnsemblBacteria" id="ABB31265">
        <property type="protein sequence ID" value="ABB31265"/>
        <property type="gene ID" value="Gmet_1024"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1024"/>
    <dbReference type="HOGENOM" id="CLU_1882785_0_0_7"/>
    <dbReference type="OrthoDB" id="2058970at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="135" mass="14657" checksum="65E163744A24C8DB" modified="2005-11-22" version="1">MKNFITTMAKELIAAFEREYAEAEQYKSTVSGTVRSLPEGMTGIWDVDGREVNVPKGTFIKADHGKAEVGASVEVEGTLSGKTLNAYRIAVTRGATEAQKIRGAVDKLPVGKYEKWSAHNAGMLVATRCRHQAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X03</accession>
    <name>Q39X03_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31221.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0979"/>
    <dbReference type="EnsemblBacteria" id="ABB31221">
        <property type="protein sequence ID" value="ABB31221"/>
        <property type="gene ID" value="Gmet_0979"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0979"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_801142_0_0_7"/>
    <dbReference type="OMA" id="TEIQRYE"/>
    <dbReference type="OrthoDB" id="1484850at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="27"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="225"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31221.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="332" mass="36493" checksum="BF51E0A30FFA8C6A" modified="2012-10-31" version="2">MTMAPENESFRTEIKRYEDILNGDPASYCFAPLAELYRKAGLLDEAIDTARKGIELHPDYVGGYLALGRACFDKGEQTESRGALERVVRVTPDNLTAQKLLSRIYRDTGENALARKALETILVLNPGDQESQAALDGLALRERSFETDTDLFSAAGEVPVDASAGFADEFLLEDAEIIEELTDEVIDEDVDEVSFAGEFTAEAGFGGEPLMVEEHGAMDEPGSDPLATATIAELYIKQGFLKKALKIYRDLLDANPGNDDLRQRIVDLKHCIDEDDARARENAFTAAMPFGEELAEAVHDKADSVGRNDAVAVLEGWLDTIGRMRQCRSVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X07</accession>
    <name>Q39X07_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Type IV pilus secretin lipoprotein PilQ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">pilQ</name>
        <name evidence="10" type="ordered locus">Gmet_0975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the bacterial secretin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514370.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0975"/>
    <dbReference type="EnsemblBacteria" id="ABB31217">
        <property type="protein sequence ID" value="ABB31217"/>
        <property type="gene ID" value="Gmet_0975"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0975"/>
    <dbReference type="eggNOG" id="COG4796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006756_0_0_7"/>
    <dbReference type="OMA" id="PRILNRQ"/>
    <dbReference type="OrthoDB" id="870677at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021731">
        <property type="entry name" value="AMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001775">
        <property type="entry name" value="GspD/PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005644">
        <property type="entry name" value="NolW-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038591">
        <property type="entry name" value="NolW-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013355">
        <property type="entry name" value="Pilus_4_PilQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011662">
        <property type="entry name" value="Secretin/TonB_short_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004846">
        <property type="entry name" value="T2SS/T3SS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11741">
        <property type="entry name" value="AMIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00263">
        <property type="entry name" value="Secretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03958">
        <property type="entry name" value="Secretin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07660">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00811">
        <property type="entry name" value="BCTERIALGSPD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00965">
        <property type="entry name" value="STN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02515">
        <property type="entry name" value="IV_pilus_PilQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0732">Signal</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223395" evidence="8">
        <location>
            <begin position="25"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="STN" evidence="9">
        <location>
            <begin position="501"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="152"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="870" mass="92121" checksum="39E6750476836FCC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X28</accession>
    <name>Q39X28_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase, beta-lactamase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31196.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365749.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0954"/>
    <dbReference type="MEROPS" id="S12.950"/>
    <dbReference type="EnsemblBacteria" id="ABB31196">
        <property type="protein sequence ID" value="ABB31196"/>
        <property type="gene ID" value="Gmet_0954"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0954"/>
    <dbReference type="eggNOG" id="COG1680">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020027_1_1_7"/>
    <dbReference type="OMA" id="WRYGHST"/>
    <dbReference type="OrthoDB" id="1439085at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="SSF56601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223401" evidence="1">
        <location>
            <begin position="21"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase" evidence="2">
        <location>
            <begin position="35"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31196.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="394" mass="42021" checksum="3B213B36881A1558" modified="2012-10-31" version="2">MCRKLFILLLILFTSLPVFAGDTPLAPFPWQNTVSRLMDKAMADGLVAGGVVVVGNRHGIVYESAFGRVSGESGALPVSTETIFDVASLTKVVATAPVVMGLVEQGRLSLADPVTRWFPEFAGKGKDGVLVEHLLTHTSGLDDFPLSASSPLLSALEGVARQKLKGEPGHRFRYADINFILLGELVRRVTGTPLDRVVSETVYGPLAMTATCFNPGPAAAGRCAATLDVGGGPQFGKVQDTTARLLDGVAGHAGIFTTAGDLARFCRMILGDGELDGQRVLAAPTLRQMAAPHFSRGGTVRRGLGWDIASPYSSPKGRGFSEASFGHTGYSGSSLWIDPENDVFVVLLSSRLDYRSTRAFSKLRNDLSTVAFAMLHPDLRELSEIAMFKAPQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X39</accession>
    <name>Q39X39_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514426.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0943"/>
    <dbReference type="EnsemblBacteria" id="ABB31185">
        <property type="protein sequence ID" value="ABB31185"/>
        <property type="gene ID" value="Gmet_0943"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0943"/>
    <dbReference type="eggNOG" id="ENOG5033FWH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_173920_0_0_7"/>
    <dbReference type="OMA" id="MDIATIY"/>
    <dbReference type="OrthoDB" id="1886092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="109" mass="12001" checksum="65957B063815AE10" modified="2005-11-22" version="1">MQTIPIALAEPEMALARDVRRTDNPQAPPICGRGTTLTESLIERLKNLGIKSITVEGHPVVIEGEKTLEDLLADLDHRFSKVANVPLMGRLQEIYRKNIIRSMGGEGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XC5</accession>
    <name>Q39XC5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Single-stranded-DNA-specific exonuclease RecJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">recJ</name>
        <name evidence="9" type="ordered locus">Gmet_0857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513002.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0857"/>
    <dbReference type="EnsemblBacteria" id="ABB31099">
        <property type="protein sequence ID" value="ABB31099"/>
        <property type="gene ID" value="Gmet_0857"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0857"/>
    <dbReference type="eggNOG" id="COG0608">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009736_5_2_7"/>
    <dbReference type="OMA" id="FIICDHH"/>
    <dbReference type="OrthoDB" id="491634at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004610">
        <property type="entry name" value="RecJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041122">
        <property type="entry name" value="RecJ_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17768">
        <property type="entry name" value="RecJ_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00644">
        <property type="entry name" value="recJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHH" evidence="6">
        <location>
            <begin position="84"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DHHA1" evidence="7">
        <location>
            <begin position="326"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="RecJ_OB" evidence="8">
        <location>
            <begin position="465"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="578" mass="61506" checksum="DBF08FCAD6952683" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XD1</accession>
    <name>QUEA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-adenosylmethionine:tRNA ribosyltransferase-isomerase</fullName>
            <ecNumber evidence="1">2.4.99.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queA</name>
        <name type="ordered locus">Gmet_0851</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-aminomethyl-7-carbaguanosine(34) in tRNA + S-adenosyl-L-methionine = adenine + epoxyqueuosine(34) in tRNA + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:32155"/>
            <dbReference type="Rhea" id="RHEA-COMP:10342"/>
            <dbReference type="Rhea" id="RHEA-COMP:10346"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82833"/>
            <dbReference type="ChEBI" id="CHEBI:82834"/>
            <dbReference type="EC" id="2.4.99.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; tRNA-queuosine biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueA family.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.17" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512996.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XD1"/>
    <dbReference type="SMR" id="Q39XD1"/>
    <dbReference type="STRING" id="269799.Gmet_0851"/>
    <dbReference type="EnsemblBacteria" id="ABB31093">
        <property type="protein sequence ID" value="ABB31093"/>
        <property type="gene ID" value="Gmet_0851"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0851"/>
    <dbReference type="eggNOG" id="COG0809">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039110_1_1_7"/>
    <dbReference type="OMA" id="YSYGDGM"/>
    <dbReference type="OrthoDB" id="368001at2"/>
    <dbReference type="UniPathway" id="UPA00392"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051075">
        <property type="term" value="F:S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1780.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00113">
        <property type="entry name" value="QueA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003699">
        <property type="entry name" value="QueA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042118">
        <property type="entry name" value="QueA_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042119">
        <property type="entry name" value="QueA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036100">
        <property type="entry name" value="QueA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30307">
        <property type="entry name" value="PTHR30307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02547">
        <property type="entry name" value="Queuosine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111337">
        <property type="entry name" value="SSF111337"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00113">
        <property type="entry name" value="queA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000231339" description="S-adenosylmethionine:tRNA ribosyltransferase-isomerase">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00113"/>
        </source>
    </evidence>
    <sequence length="343" mass="38551" checksum="FB154D6B447CB41C" modified="2005-11-22" version="1">MRVDDFDYELPPELIAQEPLDRRDATRLMTVDRLKGEVGEVSFREITRLFRPGDLLVVNDTRVIPARFFGVKESGGRVEVFLERRLAAVGERWQCLLRSSKPSRPGTRIVLAEGVSAEVIGRSDGDTWCVSFTPVTGFDEWLERNGAMPLPPYIRRSAADADRERYQTVFSRQRGAVAAPTAGLHFTPELLDELRERGVEIATLTLHVGLGTFMPIRVERVEEHRMHRERYIIPSATADAVNARKGGKGRVIALGTTTCRTLEHAARDDGRVAAGAGETGIFIYPGYHFKTVDALITNFHLPKSTLLMLVSAFAGKELLFRAYHEAVTRRFRFFSYGDAMFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XE1</accession>
    <name>Q39XE1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metallophosphoesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512985.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0841"/>
    <dbReference type="EnsemblBacteria" id="ABB31083">
        <property type="protein sequence ID" value="ABB31083"/>
        <property type="gene ID" value="Gmet_0841"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0841"/>
    <dbReference type="eggNOG" id="COG0639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023125_4_2_7"/>
    <dbReference type="OMA" id="MNGGDWY"/>
    <dbReference type="OrthoDB" id="900869at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP_ApaH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos" evidence="1">
        <location>
            <begin position="11"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="226" mass="25976" checksum="C4A9D086BE9C93A3" modified="2005-11-22" version="1">MKRTQLSRRFVIPDIHGCALTLDRLLREVIHLRRSDELYLLGDYIDRGPRSREVLDILMGLTLKGYRVFPVRGNHEEMLLESCGDRNMFRMWFENGGRATLDSFGVEDACEIPLPYRRFMAEMPYYRILPDFVLLHASLNFAIPSPFADTEAMLWSRSLEVRKEVIGGRRVIGGHTPMSRSEILRGLSTDRIVLDNGCVYRERAGMGCLAALELDSMTLSFQENID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XI3</accession>
    <name>Q39XI3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis sensory transducer, class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mcp40H-18</name>
        <name evidence="6" type="ordered locus">Gmet_0799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365725.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0799"/>
    <dbReference type="EnsemblBacteria" id="ABB31041">
        <property type="protein sequence ID" value="ABB31041"/>
        <property type="gene ID" value="Gmet_0799"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0799"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_7"/>
    <dbReference type="OMA" id="KHASAQI"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="116"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="388" mass="41233" checksum="1ECC24668F727346" modified="2005-11-22" version="1">MNLYLHLNIRTRIVLLCICYSTCIILAVIAGRSLSTAEAIASTTVFVLLGALFSSLLFRTVNDALKRIQGYLATLTGGDLMQTIAPKRNNEISSIIRSIASLQATIREIVSQISQTSEEVAMASRQLQSNADQIAAGTDNAASQTNTVAVASEEMAATSGDIANNCMRAAENSTRAVNTARSGAEVVRQATDCMERIASRVRDAAKTVEELGSRSDQIGQIIGTIQDIADQTNLLALNAAIEAARAGEQGRGFAVVADEVRALAERTTRATREIGEMIKTIQNETKGAVSAIDEGVAEVERGAEYSDKSGQSLEQILQQINDVTMQINQIATAAEQQTATTGEISSNIQQITAVVQQTARGATETATAAATLSRQADELQGLVGHFRL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-16" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XN6</accession>
    <name>RUVB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Holliday junction ATP-dependent DNA helicase RuvB</fullName>
            <ecNumber evidence="1">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ruvB</name>
        <name type="ordered locus">Gmet_0746</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a complex with RuvA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RuvB family.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514463.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XN6"/>
    <dbReference type="SMR" id="Q39XN6"/>
    <dbReference type="STRING" id="269799.Gmet_0746"/>
    <dbReference type="EnsemblBacteria" id="ABB30988">
        <property type="protein sequence ID" value="ABB30988"/>
        <property type="gene ID" value="Gmet_0746"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0746"/>
    <dbReference type="eggNOG" id="COG2255">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055599_1_0_7"/>
    <dbReference type="OMA" id="IHRMSRP"/>
    <dbReference type="OrthoDB" id="874197at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00016">
        <property type="entry name" value="DNA_helic_RuvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041445">
        <property type="entry name" value="AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004605">
        <property type="entry name" value="DNA_helicase_Holl-junc_RuvB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008824">
        <property type="entry name" value="RuvB-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008823">
        <property type="entry name" value="RuvB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42848">
        <property type="entry name" value="PTHR42848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17864">
        <property type="entry name" value="AAA_lid_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05491">
        <property type="entry name" value="RuvB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05496">
        <property type="entry name" value="RuvB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00635">
        <property type="entry name" value="ruvB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0347">Helicase</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0742">SOS response</keyword>
    <feature type="chain" id="PRO_0000235371" description="Holliday junction ATP-dependent DNA helicase RuvB">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="58"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00016"/>
        </source>
    </evidence>
    <sequence length="338" mass="37369" checksum="391E32963EF5013E" modified="2005-11-22" version="1">MTRLVTPDITEDDLIESSLRPRALDDYIGQEKAKGNLRVFIDAARKRGEALDHVLLYGPPGLGKTTLANIIACEMGVNIKSTSGPVIERPGDLAAILTNLEPHDVLFIDEIHRLSHVVEEILYPAMEDYQLDIIIGQGPSARTIKLDLPKFTLVGATTRAGLLSSPLRDRFGVISRLEFYTDDELTTIVTRSARILNIGIEPEGGRELARRSRGTPRIANRLLRRVRDFAQVRADGVITAPVVDESLKLLEIDEKGFDHMDRTIMLTIIDKFGGGPVGLDTIAAAIGEERDTIEDVYEPFLIQHGFINRTPRGRVATRAAYEHFGRIAPPSSSQGNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="40" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XR4</accession>
    <name>Q39XR4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0718"/>
    <dbReference type="EnsemblBacteria" id="ABB30960">
        <property type="protein sequence ID" value="ABB30960"/>
        <property type="gene ID" value="Gmet_0718"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0718"/>
    <dbReference type="HOGENOM" id="CLU_2436604_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="90" mass="9868" checksum="CE89B6BB49FECEA9" modified="2005-11-22" version="1">MDSTADTLGLPVSRPLALANKRPKDHLMRREFSMIRRMQPVGHRWRGGVGYSTAAISIRSVYFTAHPASAGGPFVLNAQGQCSLALFIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XV6</accession>
    <name>Q39XV6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0676</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the N(4)/N(6)-methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514067.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0676"/>
    <dbReference type="REBASE" id="11547">
        <property type="entry name" value="M.GmeII"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30918">
        <property type="protein sequence ID" value="ABB30918"/>
        <property type="gene ID" value="Gmet_0676"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0676"/>
    <dbReference type="eggNOG" id="COG2189">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_020164_1_1_7"/>
    <dbReference type="OMA" id="SLWITID"/>
    <dbReference type="OrthoDB" id="1487464at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008170">
        <property type="term" value="F:N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009007">
        <property type="term" value="F:site-specific DNA-methyltransferase (adenine-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002941">
        <property type="entry name" value="DNA_methylase_N4/N6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002295">
        <property type="entry name" value="N4/N6-MTase_EcoPI_Mod-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01555">
        <property type="entry name" value="N6_N4_Mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00506">
        <property type="entry name" value="D21N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N6_N4_Mtase" evidence="4">
        <location>
            <begin position="59"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="520" mass="58268" checksum="68715E45CED5411B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XW4</accession>
    <name>Q39XW4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rubrerythrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514276.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0668"/>
    <dbReference type="EnsemblBacteria" id="ABB30910">
        <property type="protein sequence ID" value="ABB30910"/>
        <property type="gene ID" value="Gmet_0668"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0668"/>
    <dbReference type="eggNOG" id="COG1592">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095256_1_0_7"/>
    <dbReference type="OMA" id="AYAEFVH"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01041">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024934">
        <property type="entry name" value="Rubredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50903">
        <property type="entry name" value="RUBREDOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="2">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Rubredoxin-like" evidence="1">
        <location>
            <begin position="132"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="166" mass="18449" checksum="326DC4575988B59B" modified="2005-11-22" version="1">MSTKENLANAFAGESQANRKYLAFAKQAEVDGFPQVAKLFRAAAHAETVHAHAHLRAMGGIRETVENLKEAIEGEGFEFQTMYPPYLEEAKTEGNRVAEISFRNALAVEEVHHDLYQKALAAVMNDGDLPARKVYVCEICGNTVYDFAPDKCPVCQVPKDRFTLID</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y04</accession>
    <name>RL23_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplW</name>
        <name type="ordered locus">Gmet_0628</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514239.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y04"/>
    <dbReference type="SMR" id="Q39Y04"/>
    <dbReference type="STRING" id="269799.Gmet_0628"/>
    <dbReference type="EnsemblBacteria" id="ABB30870">
        <property type="protein sequence ID" value="ABB30870"/>
        <property type="gene ID" value="Gmet_0628"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0628"/>
    <dbReference type="eggNOG" id="COG0089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037562_3_1_7"/>
    <dbReference type="OMA" id="FEVDHRA"/>
    <dbReference type="OrthoDB" id="1978865at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_L23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_L23/L15e_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_L23/L25_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_L25/23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="PTHR11620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="SSF54189"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000272751" description="50S ribosomal protein L23">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01369"/>
        </source>
    </evidence>
    <sequence length="94" mass="10830" checksum="CD288CE80B57B258" modified="2005-11-22" version="1">MNIYDILKKPLVTEKTTLEKDAKNVISFEVDRSANKIEIKNAVEKLFKVEVSEVNTVNVAGKLKRVGRHYGKRSNWKKAYVTLKEGNNVDFFEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y84</accession>
    <name>MURI_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamate racemase</fullName>
            <ecNumber evidence="1">5.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murI</name>
        <name type="ordered locus">Gmet_0547</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Provides the (R)-glutamate required for cell wall biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamate = D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:12813"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="EC" id="5.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aspartate/glutamate racemases family.</text>
    </comment>
    <dbReference type="EC" id="5.1.1.3" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30790.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365679.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y84"/>
    <dbReference type="SMR" id="Q39Y84"/>
    <dbReference type="STRING" id="269799.Gmet_0547"/>
    <dbReference type="EnsemblBacteria" id="ABB30790">
        <property type="protein sequence ID" value="ABB30790"/>
        <property type="gene ID" value="Gmet_0547"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0547"/>
    <dbReference type="eggNOG" id="COG0796">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052344_0_2_7"/>
    <dbReference type="OMA" id="MPWGPRT"/>
    <dbReference type="OrthoDB" id="1718671at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008881">
        <property type="term" value="F:glutamate racemase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00258">
        <property type="entry name" value="Glu_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015942">
        <property type="entry name" value="Asp/Glu/hydantoin_racemase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001920">
        <property type="entry name" value="Asp/Glu_race"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018187">
        <property type="entry name" value="Asp/Glu_racemase_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033134">
        <property type="entry name" value="Asp/Glu_racemase_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004391">
        <property type="entry name" value="Glu_race"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21198:SF2">
        <property type="entry name" value="PTHR21198:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01177">
        <property type="entry name" value="Asp_Glu_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53681">
        <property type="entry name" value="SSF53681"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00067">
        <property type="entry name" value="glut_race"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00923">
        <property type="entry name" value="ASP_GLU_RACEMASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00924">
        <property type="entry name" value="ASP_GLU_RACEMASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000047567" description="Glutamate racemase">
        <location>
            <begin position="1"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="1">
        <location>
            <position position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="10"/>
            <end position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="74"/>
            <end position="75"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="185"/>
            <end position="186"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00258"/>
        </source>
    </evidence>
    <sequence length="270" mass="29114" checksum="F34186A9349A471B" modified="2013-07-24" version="2">MPWKAIGIFDSGVGGLTVLKEIIKALPQEDTIYFGDTARVPYGTKSPETVTRYSLEIASFLVHRDIKLLVVACNTASACALEALQQTLSIPVVGVIEPGARRAAAVTRSGRVGVIGTEGTIRSSAYAKAIKRINPEVEVVTRACPLFVPLAEEGWTDNEVAHLTARTYLSGLREAGVDTLVLGCTHYPLLKRVIGETIGEEVKLVDSAEETARIVAEILRGGELLRPTSEQGNHHYFVSDVPAGFIRVGNRFLGGKLGDVYQVSLEAEKE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YG0</accession>
    <name>BZAF_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">5-hydroxybenzimidazole synthase</fullName>
            <shortName evidence="1">5-OHBza synthase</shortName>
            <shortName evidence="1">HBI synthase</shortName>
            <ecNumber evidence="1">4.1.99.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bzaF</name>
        <name evidence="6" type="synonym">thiC-2</name>
        <name type="ordered locus">Gmet_0471</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2015" name="Proc. Natl. Acad. Sci. U.S.A." volume="112" first="10792" last="10797">
            <title>Anaerobic biosynthesis of the lower ligand of vitamin B12.</title>
            <authorList>
                <person name="Hazra A.B."/>
                <person name="Han A.W."/>
                <person name="Mehta A.P."/>
                <person name="Mok K.C."/>
                <person name="Osadchiy V."/>
                <person name="Begley T.P."/>
                <person name="Taga M.E."/>
            </authorList>
            <dbReference type="PubMed" id="26246619"/>
        </citation>
        <scope>PREDICTED FUNCTION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 5">Catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by G.metallireducens.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + AH2 + S-adenosyl-L-methionine = 5'-deoxyadenosine + 5-hydroxybenzimidazole + A + formate + 2 H(+) + L-methionine + NH4(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:53504"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:137404"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="EC" id="4.1.99.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="2">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.23" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513840.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YG0"/>
    <dbReference type="SMR" id="Q39YG0"/>
    <dbReference type="STRING" id="269799.Gmet_0471"/>
    <dbReference type="EnsemblBacteria" id="ABB30714">
        <property type="protein sequence ID" value="ABB30714"/>
        <property type="gene ID" value="Gmet_0471"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0471"/>
    <dbReference type="eggNOG" id="COG0422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013181_2_2_7"/>
    <dbReference type="OMA" id="PYFVFGP"/>
    <dbReference type="OrthoDB" id="505395at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038521">
        <property type="entry name" value="ThiC/Bza_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002817">
        <property type="entry name" value="ThiC/BzaA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30557">
        <property type="entry name" value="PTHR30557"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01964">
        <property type="entry name" value="ThiC_Rad_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00407">
        <property type="entry name" value="phosphomethylpyrimidine_syntha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00190">
        <property type="entry name" value="thiC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000242265" description="5-hydroxybenzimidazole synthase">
        <location>
            <begin position="1"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="186"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="227"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="417"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P61425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="Q9A6Q5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="26246619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="4"/>
    <evidence type="ECO:0000305" key="5">
        <source>
            <dbReference type="PubMed" id="26246619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30714.1"/>
        </source>
    </evidence>
    <sequence length="435" mass="47670" checksum="447CF9C2A79BDCB5" modified="2005-11-22" version="1">MKTQIEIAREGTISSQMMAVAAEEHVSPDYVRQMVAEGKIVIPGNHSRKPRAVGIGKGLRTKVNASIGTSSDIIDYGAEVRKALAAQEAGADTLMELSVGGDLDRVRREVIAAVDLPVGNVPLYQAFCEAARKYGDPNKLDPEMLFDLIEKQCEDGMAFMAVHCGINLYTIERLKRQGYRYGGLVSKGGVSMVAWMMANRRENPLYEQFDRVTSILRKYDTVLSLGNGLRAGAIHDSSDRAQIQELLINCELAELGREMGCQMLVEGPGHVPLDEVEGNIQLQKRMSGGAPYYMLGPISTDVAPGFDHITAAIGAAQSSRYGADLICYITPAEHLALPNEEDVRQGVKAAKIAAYIGDMNKYPERGRERDKEMSKARRDLDWKKQFELALFPEDAKAIRASRTPEDEATCTMCGDFCASRGAGKLFAADLRGDKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YH1</accession>
    <name>Q39YH1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Flagellar basal body stator protein MotB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">motB</name>
        <name evidence="7" type="ordered locus">Gmet_0460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MotB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513829.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0460"/>
    <dbReference type="EnsemblBacteria" id="ABB30703">
        <property type="protein sequence ID" value="ABB30703"/>
        <property type="gene ID" value="Gmet_0460"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0460"/>
    <dbReference type="eggNOG" id="COG1360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_0_0_7"/>
    <dbReference type="OMA" id="NWHLSSA"/>
    <dbReference type="OrthoDB" id="1619550at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025713">
        <property type="entry name" value="MotB_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13677">
        <property type="entry name" value="MotB_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0969">Cilium</keyword>
    <keyword evidence="7" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="6">
        <location>
            <begin position="134"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="267" mass="29164" checksum="E1BD9EDD4D682BAF" modified="2005-11-22" version="1">MAKPKKEEKHVNHERWLVSYGDFLTLLFAVFVALYAMGQSDKKKVEQVMMSLRESFGFTTIQGSAAKPVVIDSTDMRIIPTITPDLINKGRSQGQKMGGRARAEEKDFRAIKAAMEAYLVKQGAQAKVSVGITQRGLVVSLKEAGFFDSGSAIVRESAYPLLAKVAESLAGYSNAVRVEGHTDTMPISSPLFPSNWELSTARATNIVHFLTKSYDFQPSAISAAGFGEYRPIADNATAEGRSKNRRVDIVLLSGEGEKAEPETTQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YH6</accession>
    <name>Q39YH6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-acetylneuraminate synthase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513823.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0455"/>
    <dbReference type="EnsemblBacteria" id="ABB30698">
        <property type="protein sequence ID" value="ABB30698"/>
        <property type="gene ID" value="Gmet_0455"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0455"/>
    <dbReference type="eggNOG" id="COG2089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040465_0_2_7"/>
    <dbReference type="OMA" id="FFASAWD"/>
    <dbReference type="OrthoDB" id="674753at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016051">
        <property type="term" value="P:carbohydrate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013132">
        <property type="entry name" value="Neu5Ac_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03102">
        <property type="entry name" value="NeuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NeuB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="286" mass="31618" checksum="1DEA34C31DA85995" modified="2005-11-22" version="1">MSSPLFVAEVSSNHHRDLERCFRFIDTAAAVGCGAVKFQLFRVEELFAPEVLAKSPVLRARKAWELPVEFLSPLAERCRKQGIQFSCTPFYLQAVEELLPYVDFYKIASYELLWNDLLRACAATGKPVILSTGMATLDEIGGAVEMLRTAGCRDLTLLHCVSGYPAPPEECNLAAIETIRSRFGCPVGWSDHSVSPAVIQRAVHQWEASAVEFHLDLEGEGEEFATGHCWLPDGIKAVIADVSTALSADGTGEKVPTPVEFPDREWRADPSDGLRPFLHVRNEWNG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-01-23" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YJ0</accession>
    <name>FLIW_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flagellar assembly factor FliW</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fliW</name>
        <name type="ordered locus">Gmet_0441</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as an anti-CsrA protein, binds CsrA and prevents it from repressing translation of its target genes, one of which is flagellin. Binds to flagellin and participates in the assembly of the flagellum.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with translational regulator CsrA and flagellin(s).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FliW family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512413.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YJ0"/>
    <dbReference type="SMR" id="Q39YJ0"/>
    <dbReference type="STRING" id="269799.Gmet_0441"/>
    <dbReference type="EnsemblBacteria" id="ABB30684">
        <property type="protein sequence ID" value="ABB30684"/>
        <property type="gene ID" value="Gmet_0441"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0441"/>
    <dbReference type="eggNOG" id="COG1699">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112356_0_2_7"/>
    <dbReference type="OMA" id="DVAVFCI"/>
    <dbReference type="OrthoDB" id="1767625at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044780">
        <property type="term" value="P:bacterial-type flagellum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01185">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003775">
        <property type="entry name" value="Flagellar_assembly_factor_FliW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024046">
        <property type="entry name" value="Flagellar_assmbl_FliW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39190">
        <property type="entry name" value="PTHR39190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02623">
        <property type="entry name" value="FliW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141457">
        <property type="entry name" value="SSF141457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <feature type="chain" id="PRO_0000272989" description="Flagellar assembly factor FliW">
        <location>
            <begin position="1"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01185"/>
        </source>
    </evidence>
    <sequence length="153" mass="16980" checksum="E94E58EB82184428" modified="2005-11-22" version="1">MKIETSRFGLLDIDDDKIITLPDAMPGFAETRFTLLNPEKHAPFCWLQSVDNPDLAFVMVDARQTLPDYAVSLTSDEYERLSLDEKSNTVVFLVVTLATDPADITVNLQGPIVLNPERMIAKQIVLEGSRFPSRHPLFGIAKGRETVETSCAG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YP5</accession>
    <name>HIS7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Imidazoleglycerol-phosphate dehydratase</fullName>
            <shortName evidence="1">IGPD</shortName>
            <ecNumber evidence="1">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisB</name>
        <name type="ordered locus">Gmet_0386</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512358.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YP5"/>
    <dbReference type="SMR" id="Q39YP5"/>
    <dbReference type="STRING" id="269799.Gmet_0386"/>
    <dbReference type="EnsemblBacteria" id="ABB30629">
        <property type="protein sequence ID" value="ABB30629"/>
        <property type="gene ID" value="Gmet_0386"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0386"/>
    <dbReference type="eggNOG" id="COG0131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044308_2_0_7"/>
    <dbReference type="OMA" id="ARHGLFD"/>
    <dbReference type="OrthoDB" id="1278103at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="PTHR23133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000010280" description="Imidazoleglycerol-phosphate dehydratase">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00076"/>
        </source>
    </evidence>
    <sequence length="195" mass="21577" checksum="F96918567717130D" modified="2005-11-22" version="1">MSRKATIERVTKETQIKLSLEIDGAGEAKICTSVPFLDHMLDLFARHGLFNLQVDARGDIDIDFHHTVEDIGIVLGQALKEALGDKKGIRRYGQASVPMDETLASVAVDISGRPYLVYHVALPKVKIGEFDVELVREFFQAVVNNLGANIHVNVMYGDNVHHMVEACFKAFARAMDQATQVDPRIEGVMSTKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YQ7</accession>
    <name>Q39YQ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ech-hydrogenase-related complex, NuoH-like integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ehrB-2</name>
        <name evidence="6" type="ordered locus">Gmet_0374</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512346.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0374"/>
    <dbReference type="EnsemblBacteria" id="ABB30617">
        <property type="protein sequence ID" value="ABB30617"/>
        <property type="gene ID" value="Gmet_0374"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0374"/>
    <dbReference type="eggNOG" id="COG0650">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_2_0_7"/>
    <dbReference type="OMA" id="ESHWIKW"/>
    <dbReference type="OrthoDB" id="1559067at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="302" mass="32014" checksum="CB0AF451F58AECED" modified="2005-11-22" version="1">MVDAVIHILITLLMPPLLLGVINRTKAIFAGRTGPPLFQAYYDLAKLVRKGSVFSETTSWVFRAGPVAGLAATLVASLLIPLGEHRPPLSFSGDMILFAYLFGLARFCTTAAALDTGSSFEGMGAAREATFACLAEPALFFSLAVLARLSGSLSLTPMLTGTAATSWLSAGASLLLLVGSLFIVLLAENCRVPFDDPTTHLELTMIHEVMVLDHSGPLFGAILYGAALKLFVLGALFTDIALPYATGIPVVDWVLFVIAMMMLAVGIGMVESVMARLRLPKVPQMLAAACILAAFSLLLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YQ9</accession>
    <name>Q39YQ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ech-hydrogenase-related complex, HyfF-like integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ehrD-2</name>
        <name evidence="4" type="ordered locus">Gmet_0372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512344.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0372"/>
    <dbReference type="EnsemblBacteria" id="ABB30615">
        <property type="protein sequence ID" value="ABB30615"/>
        <property type="gene ID" value="Gmet_0372"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0372"/>
    <dbReference type="eggNOG" id="COG0651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_10_1_7"/>
    <dbReference type="OMA" id="VEAAWKY"/>
    <dbReference type="OrthoDB" id="1887859at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="3">
        <location>
            <begin position="112"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="477" mass="51165" checksum="7C4F1703E160D246" modified="2005-11-22" version="1">MITGILLIPLLGAITAWLIPSDRSRPWVLPVVGTLHLALTIEAALTPTSPSVGMWLHLDAIGKLVLLSVSLLFFASGLYAVEYLAYRRERPNRLLCAMLPVCLSAMTLVAFAHHLGLLWVAIETTTLTMTPLLYFNRNARSIEATWKYMLICSVGIALALLGLLFLAYSTVVARIEPTLLLEPLVANARLLSPAWLKAAFVFLLVGYGTKMGLAPLHTWKPDAYGEAPGLVGGLLAGGLVTCSFVGLLRAYQVCVAANGTTFHRDALVLMGLLSMATAAVFMARQADFKRMLAYSSVEHVGILAVALGLGKGALAGALLHLVNNSLTKGVLFLAAANIHRSYNSKRCEQVRGALRRLPWSGGLFLAGFFAVTGSPPFGLFVSEFSIISSAMTQGGEWIGGLILFFLAAIFLGMARTVLPVVMGESSRIEHTGYRDRFLTVVPPLILMGVVLMLGIWIPEPLSRLITEGAALLGGNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z13</accession>
    <name>Q39Z13_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513583.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0266"/>
    <dbReference type="EnsemblBacteria" id="ABB30511">
        <property type="protein sequence ID" value="ABB30511"/>
        <property type="gene ID" value="Gmet_0266"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0266"/>
    <dbReference type="HOGENOM" id="CLU_1935027_0_0_7"/>
    <dbReference type="OMA" id="LEHLFIY"/>
    <dbReference type="OrthoDB" id="2003700at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="5"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="14388" checksum="3F0252E7415887EE" modified="2005-11-22" version="1">MGQFERRRHPRVPFSAPAFLEKDSRITYGEVRDISHHGLFLSMRGDCEPGKEALVSIYFLSGTSTLTITMPGRIVRTASNGIGFASPHLDPLQILSYESVFSFGYDPPQLMEEFLAHADTLAPGKEGITT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-07-01" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z65</accession>
    <name>DAPAT_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LL-diaminopimelate aminotransferase</fullName>
            <shortName evidence="1">DAP-AT</shortName>
            <shortName evidence="1">DAP-aminotransferase</shortName>
            <shortName evidence="1">LL-DAP-aminotransferase</shortName>
            <ecNumber evidence="1">2.6.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dapL</name>
        <name type="ordered locus">Gmet_0213</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H(+) + H2O + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23988"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16845"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57609"/>
            <dbReference type="EC" id="2.6.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (aminotransferase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.83" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512802.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z65"/>
    <dbReference type="SMR" id="Q39Z65"/>
    <dbReference type="STRING" id="269799.Gmet_0213"/>
    <dbReference type="EnsemblBacteria" id="ABB30459">
        <property type="protein sequence ID" value="ABB30459"/>
        <property type="gene ID" value="Gmet_0213"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0213"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051433_0_0_7"/>
    <dbReference type="OMA" id="DFQARGC"/>
    <dbReference type="OrthoDB" id="417859at2"/>
    <dbReference type="UniPathway" id="UPA00034">
        <property type="reaction ID" value="UER00466"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010285">
        <property type="term" value="F:L,L-diaminopimelate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033362">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate, diaminopimelate-aminotransferase pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01642">
        <property type="entry name" value="DapL_aminotrans_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019942">
        <property type="entry name" value="DapL/ALD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43144">
        <property type="entry name" value="PTHR43144"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03542">
        <property type="entry name" value="DAPAT_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0032">Aminotransferase</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000342238" description="LL-diaminopimelate aminotransferase">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="108"/>
            <end position="109"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="246"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01642"/>
        </source>
    </evidence>
    <sequence length="410" mass="45135" checksum="15A33F2EE96CDC11" modified="2005-11-22" version="1">MAKINDNYLKLKAGYLFPEIGRRVREFSAANPEAKVIRLGIGDVTRPLAPAIIKAFHDAVDDLATIDNFAGYGPEQGYDWLINAIIEKSYKPLGVSLKTEEMFISDGSKCDCANILDIFALDNVVAIGDPVYPVYNDTNVMIGRTGDADEKGYYKGIVYMPCTEANGFIPSLPTEKVDIIYLCFPNNPTGTVATKAELKKWVDYANANDAVIFFDAAYEAFITDPAIPHSIYEIEGAKKCAIEFRSFSKTAGFTGVRCGLVVVPEEVMGTTPTGEKYSFNKLWLRRTTTKFNGASYPVQKAAAAVYSDEGWKQNKEIIDYYMENARIIREGLAAAGLTVYGGVNAPYIWLKTPGGMSSWDFFDKLLTECNVVGTPGSGFGPSGEGFFRLSAFGHRENVIEAVERIKKNLK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z86</accession>
    <name>RF3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptide chain release factor 3</fullName>
            <shortName evidence="1">RF-3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">prfC</name>
        <name type="ordered locus">Gmet_0192</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365632.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z86"/>
    <dbReference type="SMR" id="Q39Z86"/>
    <dbReference type="STRING" id="269799.Gmet_0192"/>
    <dbReference type="PRIDE" id="Q39Z86"/>
    <dbReference type="EnsemblBacteria" id="ABB30438">
        <property type="protein sequence ID" value="ABB30438"/>
        <property type="gene ID" value="Gmet_0192"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0192"/>
    <dbReference type="eggNOG" id="COG4108">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_2_1_7"/>
    <dbReference type="OMA" id="TPASWPI"/>
    <dbReference type="OrthoDB" id="164090at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04169">
        <property type="entry name" value="RF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00072">
        <property type="entry name" value="Rel_fac_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004548">
        <property type="entry name" value="PrfC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032090">
        <property type="entry name" value="RF3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038467">
        <property type="entry name" value="RF3_dom_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041732">
        <property type="entry name" value="RF3_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43556">
        <property type="entry name" value="PTHR43556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16658">
        <property type="entry name" value="RF3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00503">
        <property type="entry name" value="prfC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000242179" description="Peptide chain release factor 3">
        <location>
            <begin position="1"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="10"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00072"/>
        </source>
    </evidence>
    <sequence length="527" mass="59517" checksum="5088BE47E56B37CD" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZB7</accession>
    <name>Q39ZB7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pyridoxamine-5'-phosphate oxidase-related FMN-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512747.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0160"/>
    <dbReference type="EnsemblBacteria" id="ABB30407">
        <property type="protein sequence ID" value="ABB30407"/>
        <property type="gene ID" value="Gmet_0160"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0160"/>
    <dbReference type="eggNOG" id="COG3576">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_163878_0_0_7"/>
    <dbReference type="OMA" id="MVNTWNS"/>
    <dbReference type="OrthoDB" id="1650305at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="Putative_PNPOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Putative_PNPOx" evidence="1">
        <location>
            <begin position="3"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="123" mass="13371" checksum="99DE0D5A02B3525A" modified="2005-11-22" version="1">MIPEKLLEIMKQDGVVAIATLGEDGPHMVNTWNSYIKVSQDGRLFIPAGYMHKTEANIAHNPDVLITLGSSKVAGLHGPGAGFLIKGKANFITSGPDFDFMKAKFNWLRATLAVTIESATQTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZD6</accession>
    <name>Q39ZD6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512724.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0139"/>
    <dbReference type="EnsemblBacteria" id="ABB30388">
        <property type="protein sequence ID" value="ABB30388"/>
        <property type="gene ID" value="Gmet_0139"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0139"/>
    <dbReference type="eggNOG" id="COG5295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_749562_0_0_7"/>
    <dbReference type="OMA" id="HATIISD"/>
    <dbReference type="OrthoDB" id="938227at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223484" evidence="1">
        <location>
            <begin position="27"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="376" mass="37685" checksum="0C752E0BF164D954" modified="2005-11-22" version="1">MGQGIRTAVVTVAALAAWGAGSGVFAAGIDDGAVTAPKLADGAVTYRAIVPGAVTNSKIVDGAVTDEKLGFGAVTTPKLADGAVTDAKIAGPIAGHKIGRHGHDAADIVQGTIDAARLPVGTAPGTVAAGDHTHEGLLRRPAELITVALSGGDFTNPIDALNSITDASADKPYLVKIMPGTYDLGIDTLVMKSYVDIEGSGELTTRLRGNAADAGVVAGASMAELRNLTVQASGTEGTIVGIFNGSAAPRIAHVTVSAEGGKGAYGIYNLMAAPVIADVTVLAGGSDTAFGVFNLHSSPIVRNSAIKAGNGIYSYYSGTVTVEGTSVNASLTTLFTDVGATTLVANSRLTGGRPASNGIMKCVGVYDGNYEPVSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZD8</accession>
    <name>Q39ZD8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="2">PPIase</shortName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">ppiA</name>
        <name evidence="4" type="ordered locus">Gmet_0137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512722.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0137"/>
    <dbReference type="EnsemblBacteria" id="ABB30386">
        <property type="protein sequence ID" value="ABB30386"/>
        <property type="gene ID" value="Gmet_0137"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0137"/>
    <dbReference type="eggNOG" id="COG0652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012062_16_9_7"/>
    <dbReference type="OMA" id="VPFHRVM"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000413">
        <property type="term" value="P:protein peptidyl-prolyl isomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044665">
        <property type="entry name" value="E_coli_cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43246">
        <property type="entry name" value="PTHR43246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="SSF50891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006528777" description="Peptidyl-prolyl cis-trans isomerase" evidence="2">
        <location>
            <begin position="27"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="3">
        <location>
            <begin position="34"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="199" mass="21377" checksum="648E1048BF6D6413" modified="2005-11-22" version="1">MFKRIILALTICGLFSVLLIAGNADAAAKAEKAKNPVVLMETTLGPVKIELYPDKAPVSVKNFLDYVNSGFYNGTIFHRVIPGFMAQGGGFTADRKQKETKAPIKNEAANGLKNDRGTIAMARTANPDSATAQFFINVVNNDGLNRPNPDGFGYAVFGKVVEGMDVVDKIVATPTQRLNMVFANLPVTPVVITSMKAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZF1</accession>
    <name>Q39ZF1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Radical SAM domain iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514129.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0124"/>
    <dbReference type="EnsemblBacteria" id="ABB30373">
        <property type="protein sequence ID" value="ABB30373"/>
        <property type="gene ID" value="Gmet_0124"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0124"/>
    <dbReference type="eggNOG" id="COG4277">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033784_0_0_7"/>
    <dbReference type="OMA" id="GYIHLKA"/>
    <dbReference type="OrthoDB" id="940969at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023874">
        <property type="entry name" value="DNA_rSAM_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21180:SF9">
        <property type="entry name" value="PTHR21180:SF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01102">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03916">
        <property type="entry name" value="rSAM_link_UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="6">
        <location>
            <begin position="62"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="431" mass="47434" checksum="BE91A0F94539BE0E" modified="2005-11-22" version="1">MPELSLAEKLEILADGAKYDVSCASSGSSRRNKGGIGNAAQCGICHSWTADGRCVSLLKILLTNACIYDCAYCVNRRSNDTRRVLLTPAEVAELTIGFYRRNAIEGLFLSTGVVKDPDHTMELLIEATSILREEHRFNGYIHVKVVPGADLLLVDRLGRLADRVSVNMELPSRESLQLLAPDKSREAIVAPMKRVGELIVQTKEERKVSRKIPPFAPAGQSTQLIIGASGESDLQIVSLAAGLYGRLSMKRVYYSAFIPVNTDTRLPSVVGTPPLVREHRLYQADWLMRYYGFAAGELLDEEHPNLDLSLDPKAGWALRNLHLFPVEVNRAPLELLLRVPGIGVRSAQRIVGARRGGHLSLDDLALLGVVMKRARYFVTARGRFGADMTPDAAGLQARLTERTTPRPRWSQPSLFDGANAIDIRSTITGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZG1</accession>
    <name>Q39ZG1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514119.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0114"/>
    <dbReference type="EnsemblBacteria" id="ABB30363">
        <property type="protein sequence ID" value="ABB30363"/>
        <property type="gene ID" value="Gmet_0114"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0114"/>
    <dbReference type="HOGENOM" id="CLU_146776_1_0_7"/>
    <dbReference type="OMA" id="IGLNFRK"/>
    <dbReference type="OrthoDB" id="1935411at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="2"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="133" mass="15063" checksum="FF58BD0191665836" modified="2005-11-22" version="1">MEKRKFERVDLRTEAVVRHRDLTFRGEVENLSLKGLFVRTDQKIPLHEKVDVAMFFQGSSSELSFSLEANVVRATDQGIGLNFRKIDIDSLVRSDVLSSAGGDRRQVIEEFYGFAENNEATEEEKSKVPPVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZG6</accession>
    <name>Q39ZG6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Peptidase, M48 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_0109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7 8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M48 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365626.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0109"/>
    <dbReference type="EnsemblBacteria" id="ABB30358">
        <property type="protein sequence ID" value="ABB30358"/>
        <property type="gene ID" value="Gmet_0109"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0109"/>
    <dbReference type="eggNOG" id="COG0501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025947_1_0_7"/>
    <dbReference type="OMA" id="LPFKIYK"/>
    <dbReference type="OrthoDB" id="1918093at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 8" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 7 8" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="147"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48_N" evidence="11">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M48" evidence="10">
        <location>
            <begin position="206"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB30358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="421" mass="47029" checksum="E32C5311061CEC87" modified="2005-11-22" version="1">MTAVIILFYLITLGAGFFLRTLNLRHLKRYGSTVPSGFEGAVEPETLRKTVAYTLDQSRLGLAESLFDAALLLIFLFGLLPAYDRWLASLGGSFVLSGVLFFLGLTLIQTFLGIPFDLYGTFRLEVRYGFNTTTPGLWLSDLAKSTLIAVVLTGLLVAGAFALVAWSPRFWWLWVWGFFAMVSLFLMYLSPYVIEPLFNRFEPVAEEGLEEEIRALCERAGLRVSRVMQVDASRRSRHSNAYFTGIGRVKRIVLYDTLIRQMSHREILAVLAHEIGHWKKGHIRRRLILTEAGALAGSWFAWKLTGWEGFPGLIGLTDASFAARLVILGFLGSIVSFPFTPLSSWLSRRHEREADRFATDITGDAEALASALVKLSTENLSNLHPHPLYAAFYYSHPPVVERVGRLRAAMPPAGKAGETTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZK5</accession>
    <name>Q39ZK5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Endonuclease III-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nth</name>
        <name evidence="7" type="ordered locus">Gmet_0070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514194.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0070"/>
    <dbReference type="EnsemblBacteria" id="ABB30319">
        <property type="protein sequence ID" value="ABB30319"/>
        <property type="gene ID" value="Gmet_0070"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0070"/>
    <dbReference type="eggNOG" id="COG2231">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012862_6_0_7"/>
    <dbReference type="OMA" id="GPQGWWP"/>
    <dbReference type="OrthoDB" id="1381897at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="SSF48150"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENDO3c" evidence="6">
        <location>
            <begin position="37"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="HhH1" evidence="5">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="223" mass="24866" checksum="6CE30692C91C56F2" modified="2005-11-22" version="1">MLDAVLQEIFDILHAAYGPRHWWPADTPFEVCVGAILTQNTNWGNVEKAISNLKRESLLSPEALRDVPAASLAEAIRPAGYFNVKSLRLKDFAGYLWERHGGSLERMFAGDWHALREELLGVRGIGPETADSILLYAGGKPTFVVDAYTKRLFAALGILNGSAGYDEVRDLFMANLPPDVRLFNEYHALIVEHGKRHCRKRPLCPGCGLHLFCRSHVTERPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZP1</accession>
    <name>Q39ZP1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, AAA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30283.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513799.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0033"/>
    <dbReference type="EnsemblBacteria" id="ABB30283">
        <property type="protein sequence ID" value="ABB30283"/>
        <property type="gene ID" value="Gmet_0033"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0033"/>
    <dbReference type="eggNOG" id="COG2766">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_360470_0_0_7"/>
    <dbReference type="OMA" id="PRVLHNF"/>
    <dbReference type="OrthoDB" id="49410at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013153">
        <property type="entry name" value="Prk_AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010650">
        <property type="entry name" value="PrkA_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08298">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06798">
        <property type="entry name" value="PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00763">
        <property type="entry name" value="AAA_PrkA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_PrkA" evidence="1">
        <location>
            <begin position="24"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30283.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="764" mass="89385" checksum="237E97009C563F6E" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYH3</accession>
    <name>J7LYH3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3656"/>
    <dbReference type="EnsemblBacteria" id="AFR42838">
        <property type="protein sequence ID" value="AFR42838"/>
        <property type="gene ID" value="Gmet_3656"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3656"/>
    <dbReference type="HOGENOM" id="CLU_3043848_0_0_7"/>
    <dbReference type="OMA" id="PEAHTFG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="57" mass="6051" checksum="2AAD6C8B7D7B7CD1" modified="2012-10-31" version="1">MRHGIAHDKLCTIEDTRTISSLSANATVSCSKCGVKAHDPADVCDPVQLPEAHTFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2022-08-03" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>J7M092</accession>
    <name>J7M092_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3617"/>
    <dbReference type="EnsemblBacteria" id="AFR42817">
        <property type="protein sequence ID" value="AFR42817"/>
        <property type="gene ID" value="Gmet_3617"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3617"/>
    <dbReference type="HOGENOM" id="CLU_216338_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="48" mass="5573" checksum="2AEAE27C19019F35" modified="2012-10-31" version="1">MKLLNWKLTIGGLSELDCQIEKLRKLRDSYREANVAYYGKEIADLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-09-29" version="35" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEM9</accession>
    <name>J9JEM9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anti-sigma factor antagonist</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rsbV</name>
        <name evidence="4" type="ordered locus">Gmet_1229</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the anti-sigma-factor antagonist family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1229"/>
    <dbReference type="EnsemblBacteria" id="AFR42814">
        <property type="protein sequence ID" value="AFR42814"/>
        <property type="gene ID" value="Gmet_1229"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1229"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_3440779_0_0_7"/>
    <dbReference type="OMA" id="HNSTELK"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043856">
        <property type="term" value="F:anti-sigma factor antagonist activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003658">
        <property type="entry name" value="Anti-sigma_ant"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00377">
        <property type="entry name" value="ant_ant_sig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="3">
        <location>
            <begin position="21"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="AFR42814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="111" mass="12621" checksum="F9F984F0CE105496" modified="2012-10-31" version="1">MNLKRKKKNEILIIFVKEERLDAHNSNDLKGKMQELFEQGKKNILVDLTDIRFIDSSGLGALVSGFKNAISHQGSLKLSSLQPQVKSMFELTRLHRVFEIFGSTAEALENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PU7</accession>
    <name>Q39PU7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Outer membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3522</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513679.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3522"/>
    <dbReference type="EnsemblBacteria" id="ABB33727">
        <property type="protein sequence ID" value="ABB33727"/>
        <property type="gene ID" value="Gmet_3522"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3522"/>
    <dbReference type="HOGENOM" id="CLU_1370481_0_0_7"/>
    <dbReference type="OMA" id="YFVEKHV"/>
    <dbReference type="OrthoDB" id="1525461at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223124" evidence="1">
        <location>
            <begin position="24"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="OMP_b-brl" evidence="2">
        <location>
            <begin position="10"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="201" mass="21110" checksum="71D03D3EF8F203C6" modified="2005-11-22" version="1">MKRLVTVAWIVVAVAGLSGTALADSIKGKLGVTGRLGVYLPAESDFDDRKLETDVGFIGGGGVIYGITDNIAAEIDVTHTEFGSNRVSGLDEGDFEVVNVSLGGQYRFLLPQSKFVPYAGGGLDILLIDYTRPSGTKAHVDTGVGVHVNGGVDYFVTRQLVLNAEVKGVIAPEVDMTAEGRPGNFDPSGVAGTVGVRFFFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PY2</accession>
    <name>Q39PY2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptidoglycan L,D-transpeptidase lipoprotein, YkuD family, TPR domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_3487</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YkuD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33692.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3487"/>
    <dbReference type="EnsemblBacteria" id="ABB33692">
        <property type="protein sequence ID" value="ABB33692"/>
        <property type="gene ID" value="Gmet_3487"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3487"/>
    <dbReference type="eggNOG" id="COG3034">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899437_0_0_7"/>
    <dbReference type="OMA" id="SYPNERD"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071972">
        <property type="term" value="F:peptidoglycan L,D-transpeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16913">
        <property type="entry name" value="YkuD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005490">
        <property type="entry name" value="LD_TPept_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038063">
        <property type="entry name" value="Transpep_catalytic_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03734">
        <property type="entry name" value="YkuD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141523">
        <property type="entry name" value="SSF141523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="YkuD" evidence="6">
        <location>
            <begin position="198"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33692.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="333" mass="37291" checksum="8A20C9FD11896068" modified="2012-10-31" version="2">MRGPEIFRRGPSAESGRSLADTATKQSRPGKRLSFFRIGILVTPMLMAGCGHLQSKPTFEEANDLFNQGSYQASLSKYEQIVDQQPAAGDRALFEMGIVYSYPKNERKDYQKSLECFQRVIKDYPGSHYRQNSQTMASYINTVPVKDATIATQQTRIEALQRELTGKEDEIAALRGKIEALEKNVFAYAIRKPSLDKILIEKQARRMMLISKGAVLKTYRIALGGDPIGPKERQGDNKTPEGAYTIDARNRDSRYHRALHISYPNERDRKRARELGVSPGGNIMIHGIKNGFSWVGDAHAGVDWTKGCIAVTDEEIEEIDTLAPNGTIVEIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q60</accession>
    <name>Q39Q60_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thiamin biosynthesis protein ThiI-related adenine nucleotide alpha hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3402</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514209.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3402"/>
    <dbReference type="EnsemblBacteria" id="ABB33614">
        <property type="protein sequence ID" value="ABB33614"/>
        <property type="gene ID" value="Gmet_3402"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3402"/>
    <dbReference type="eggNOG" id="COG0301">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053822_0_0_7"/>
    <dbReference type="OMA" id="CIDCHAN"/>
    <dbReference type="OrthoDB" id="1230735at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004810">
        <property type="term" value="F:tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020536">
        <property type="entry name" value="ThiI_AANH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02568">
        <property type="entry name" value="ThiI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ThiI" evidence="3">
        <location>
            <begin position="3"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="334" mass="37322" checksum="ED6115BE6C72B282" modified="2005-11-22" version="1">MKRKALALLSGGLDSTLAVKVMLEQGIEVEALNFTSPFCTCTGKNAGCKSEAIRVAEEFGIPIKVMHKGVDYLEVVRKPKHGYGKGMNPCIDCRIFLLRKAKEYLEESGADFVITGEVLGQRPMSQRRHTLDIIERESGLAGRLLRPLSAKHFEPTLPEQEGWVDREKLLAIQGRSRKEQMQLAEELDVKNYPCPAGGCLLTEVSFVSKVRDVFDHSDQLNLRDFRLLKVARHFRVGPRTKVLIGRNEAENELLSHNIQPGEATLRWLDGSSPLGVLMGVVDDALLETSAKILLRYTRAEAGAECRVKVVIDDNERIIVVPNEFSDPAIESYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QD6</accession>
    <name>Q39QD6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512549.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3325"/>
    <dbReference type="EnsemblBacteria" id="ABB33538">
        <property type="protein sequence ID" value="ABB33538"/>
        <property type="gene ID" value="Gmet_3325"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3325"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_4_2_7"/>
    <dbReference type="OMA" id="FGFECPP"/>
    <dbReference type="OrthoDB" id="554560at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="48"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="434" mass="49029" checksum="78B725242AF3A5E7" modified="2005-11-22" version="1">MRNELVTPGAGELTYEIRNIVNVAEKLQKHGVKINWENIGDPIVKGEEIPRWMKEIVANEVMENDTWGYCHTRGVLETREFICGLTNNRGGARITPDDIIFFNGLGDAISTVYGNLRHESRILMPSPTYTTHSIGEAAHAQASPVCYRLDPANNWFPDLEDMENHVRYNPQISGILLINPDNPTGMVFSRETLEKIVAIARKYELFIIADEVYNNITYNGQTTVPISDVIGDVPAIAMKGISKEIPWPGSRCGWIEVYNGAKDDQFRKYINSILSAKMNEVCSTTLPQKCIPAIMKHPEYQTYLQERIRRYEKMSTITFDCLREVPELMVNRTNGAFYMSVAFRDGLLTNGQSLPIENAEVRELVEGLVNAPGVSPDKRFVYYLLASTGICIVPLSSFNTPLQGFRVTLLEKDEAECLRIYQTLAKKIAEYLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QF4</accession>
    <name>Q39QF4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Short-chain acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_3307</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512531.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3307"/>
    <dbReference type="EnsemblBacteria" id="ABB33520">
        <property type="protein sequence ID" value="ABB33520"/>
        <property type="gene ID" value="Gmet_3307"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3307"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_7"/>
    <dbReference type="OMA" id="YAIPQQW"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="BRENDA" id="1.3.8.11">
        <property type="organism ID" value="2414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="5"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="121"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="227"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="380" mass="41325" checksum="ADA5F22485D7D6B6" modified="2005-11-22" version="1">MFNTSEEVRIVTETIRQAARERIAPAAASVDATGELDGEVLSLLWDLGLMTLVFPPEFGGAEQSQGTLLCTAVEEIARHCASSSLMLIIQAVGSFPLLHGGSRELLERVLPRIVERRELAAYLVSEPGAGSDVGSIRTTAVRDGNEYVISGTKCFSTNGPVASYYTVLARTSENGRNGLSFFLVDGDAPGLKVGKIEKKLGQRGSKTSEMYLDEVRVPAGNLLGEENKGFLLAMKDFDMSRPAIGAQALGIAEGAFDQMLKHSRERKTFGQPLCEHQMIQQIIADSATKIEAARGLIYRAAALYDQGKRNTKLASMGKLFASDAAMQITTDAIQVFGGYGYMQDYPVERMFRDAKLTQIFEGANQIQRLVIAREILKEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QI9</accession>
    <name>Q39QI9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase 3</fullName>
            <ecNumber evidence="8">2.3.1.180</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">3-oxoacyl-[acyl-carrier-protein] synthase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Beta-ketoacyl-ACP synthase III</fullName>
            <shortName evidence="8">KAS III</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fabH</name>
        <name evidence="11" type="synonym">fabH-1</name>
        <name evidence="11" type="ordered locus">Gmet_3272</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>acetyl-CoA + H(+) + malonyl-[ACP] = 3-oxobutanoyl-[ACP] + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9625"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78450"/>
            <dbReference type="EC" id="2.3.1.180"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the thiolase-like superfamily. FabH family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.180" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512709.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3272"/>
    <dbReference type="EnsemblBacteria" id="ABB33485">
        <property type="protein sequence ID" value="ABB33485"/>
        <property type="gene ID" value="Gmet_3272"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3272"/>
    <dbReference type="eggNOG" id="COG0332">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039592_3_1_7"/>
    <dbReference type="OMA" id="AIENLCT"/>
    <dbReference type="OrthoDB" id="872193at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033818">
        <property type="term" value="F:beta-ketoacyl-acyl-carrier-protein synthase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01815">
        <property type="entry name" value="FabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013751">
        <property type="entry name" value="ACP_syn_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013747">
        <property type="entry name" value="ACP_syn_III_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004655">
        <property type="entry name" value="FabH_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08545">
        <property type="entry name" value="ACP_syn_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08541">
        <property type="entry name" value="ACP_syn_III_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="SSF53901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00747">
        <property type="entry name" value="fabH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4 8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACP_syn_III" evidence="10">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="ACP_syn_III_C" evidence="9">
        <location>
            <begin position="239"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="ACP-binding" evidence="8">
        <location>
            <begin position="254"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="326" mass="34925" checksum="B93E12F7C9543D17" modified="2005-11-22" version="1">MIYAEIVATGGCVPERVVPNDFFNYLVDDADTWIASRTGIRERRFASPKESTSDLATAAARSALARANMEPGELDCIIVGTSTPDMYLPATACMVQKNIGAKNAVAFDMNAVCSGFIFGVETADNFIRSGKYRRVMVIGADTYSKILDFDDKGTCPLFGDGASAVILGATEEKRGILQSMIFSDGGGWELIQVPSSGSRCPVTAETIAAHDNTFKMSGKQVFVFATDVIPRIIEQVTTRAGVSVGDLDYIIPHQANVRIIDFISKKTGLGKERFLLNLDRYGNTAAASVGLALDENLRNGTLKPGQLVLIMGFGGGLSWGGALIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QJ1</accession>
    <name>Q39QJ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33483.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512707.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33483">
        <property type="protein sequence ID" value="ABB33483"/>
        <property type="gene ID" value="Gmet_3270"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3270"/>
    <dbReference type="HOGENOM" id="CLU_2167340_0_0_7"/>
    <dbReference type="OMA" id="PHCPALA"/>
    <dbReference type="OrthoDB" id="2100006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33483.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="110" mass="11746" checksum="0A81FB7A31C2EB85" modified="2012-10-31" version="2">MALFSGMKLFVIIAFNALWPRTKRGGAPLRNAASHLPSVPPGFTPVAPAGIPPILADPGRAVNAEGDLSLFFPGCPALAAPFLLFRLKRLGFSRCRVRLLPEGLALTARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QL5</accession>
    <name>Q39QL5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycolate oxidase iron-sulfur subunit</fullName>
            <ecNumber evidence="4">1.1.99.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">larF</name>
        <name evidence="6" type="ordered locus">Gmet_3246</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of a complex that catalyzes the oxidation of glycolate to glyoxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-lactate + A = AH2 + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:15089"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>A + glycolate = AH2 + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:21264"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29805"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="1.1.99.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="4">Binds 2 [4Fe-4S] clusters.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.14" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512684.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3246"/>
    <dbReference type="EnsemblBacteria" id="ABB33459">
        <property type="protein sequence ID" value="ABB33459"/>
        <property type="gene ID" value="Gmet_3246"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3246"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023081_0_1_7"/>
    <dbReference type="OMA" id="VYQDACH"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012257">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13183">
        <property type="entry name" value="Fer4_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000139">
        <property type="entry name" value="Glc_ox_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="5"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="421" mass="45686" checksum="429BA3D6505BAF01" modified="2005-11-22" version="1">MDPLKRVENELKKCVKCGACRAHCPAFATFGKEPAVARGKVALAQHLLKGDIELDDATYAAMSKCLLCGSCVEKCPNDVPTDEIVVVAREALSGQRGLTTFHAAVGRVIRNRSLMKFGAAAARILGPLFFRKVPETSGLRLRFPLPFLGGKRHIPSIAKKPFLDRHPEVIPGEPGKPRIVYFVGCMTNFCYPQVGEAALALFRHLGCTVIIPKNQQCCGLPGMSGGDLDTVRGLAEKNLAELERYEADYIMTACATCGGALHKFYPNLVGKRHPELAARLKAIAEKTVDAAQLLQKLGLNPEETGAGSDIRVTYHDPCHLRTRAITRQPRELLQGTPGVELAEMEGADKCCGLGGTFNVYHYESSLAINKMKSAAIINTGADAVVTGCPGCMMQLSDGLKQQRNRTRVLHTLEILARSIRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QM6</accession>
    <name>Q39QM6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Uroporphyrinogen-III C-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">hemD</name>
        <name evidence="11" type="ordered locus">Gmet_3235</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="7">Porphyrin-containing compound metabolism; siroheme biosynthesis; precorrin-2 from uroporphyrinogen III: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.107" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366164.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3235"/>
    <dbReference type="DNASU" id="3740951"/>
    <dbReference type="EnsemblBacteria" id="ABB33448">
        <property type="protein sequence ID" value="ABB33448"/>
        <property type="gene ID" value="Gmet_3235"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3235"/>
    <dbReference type="eggNOG" id="COG0007">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1587">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011276_6_0_7"/>
    <dbReference type="OMA" id="VTGRYEW"/>
    <dbReference type="OrthoDB" id="1185397at2"/>
    <dbReference type="UniPathway" id="UPA00262">
        <property type="reaction ID" value="UER00211"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004851">
        <property type="term" value="F:uroporphyrin-III C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019354">
        <property type="term" value="P:siroheme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11642">
        <property type="entry name" value="SUMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006366">
        <property type="entry name" value="CobA/CysG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003043">
        <property type="entry name" value="Uropor_MeTrfase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="SSF69618"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01469">
        <property type="entry name" value="cobA_cysG_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00839">
        <property type="entry name" value="SUMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00840">
        <property type="entry name" value="SUMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="9">
        <location>
            <begin position="11"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="HEM4" evidence="10">
        <location>
            <begin position="275"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="513" mass="55000" checksum="705AEE2A42BF1A82" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QN4</accession>
    <name>Q39QN4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366163.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3227"/>
    <dbReference type="EnsemblBacteria" id="ABB33440">
        <property type="protein sequence ID" value="ABB33440"/>
        <property type="gene ID" value="Gmet_3227"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3227"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1729">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_327002_0_0_7"/>
    <dbReference type="OMA" id="INHVGPL"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001434">
        <property type="entry name" value="DUF11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01345">
        <property type="entry name" value="DUF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004222990" evidence="3">
        <location>
            <begin position="32"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="domain" description="DUF11" evidence="4">
        <location>
            <begin position="898"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="159"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="996" mass="107380" checksum="4897F355AB8C88B6" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QR5</accession>
    <name>RL27_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmA</name>
        <name type="ordered locus">Gmet_3196</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512634.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QR5"/>
    <dbReference type="SMR" id="Q39QR5"/>
    <dbReference type="STRING" id="269799.Gmet_3196"/>
    <dbReference type="EnsemblBacteria" id="ABB33409">
        <property type="protein sequence ID" value="ABB33409"/>
        <property type="gene ID" value="Gmet_3196"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3196"/>
    <dbReference type="eggNOG" id="COG0211">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095424_4_0_7"/>
    <dbReference type="OMA" id="GKDHTLH"/>
    <dbReference type="OrthoDB" id="1904463at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00539">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_L27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_L27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="PTHR15893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00062">
        <property type="entry name" value="L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_1000017487" description="50S ribosomal protein L27">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="85" mass="9328" checksum="23F84A58AC6DB6AF" modified="2005-11-22" version="1">MAHKKGVGSTRNGRDSESKRLGCKKYGGENVKAGNIIYRQRGTQIHPGTNVGCGKDYTLFALIDGVVKFERLGRDRKKVSVYPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QS5</accession>
    <name>Q39QS5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alkyl hydroperoxide reductase C</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Peroxiredoxin</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">prx-2</name>
        <name evidence="9" type="ordered locus">Gmet_3186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512624.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3186"/>
    <dbReference type="EnsemblBacteria" id="ABB33399">
        <property type="protein sequence ID" value="ABB33399"/>
        <property type="gene ID" value="Gmet_3186"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3186"/>
    <dbReference type="eggNOG" id="COG0450">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_21_1_7"/>
    <dbReference type="OMA" id="WWPKDFT"/>
    <dbReference type="OrthoDB" id="892697at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB33399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="201" mass="22050" checksum="49D3388B826A9190" modified="2005-11-22" version="1">MCMCTLVTKEAPDFAADAVLPDNTFATIKLSSFRGKYVILFFYPLDFTFVCPSEILAFNKKLDQFKAKNCEVIGVSVDSKFTHLAWKNTKVEDGGIGNIQYPLVSDLKKEIATQFGVLFENGGVALRGLFLIDTKGIVRHAVINDLPLGRSVDEALRMLDALQFVETHGDQVCPANWREGDEAMKPTAAGVADYLAKHAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QV0</accession>
    <name>Q39QV0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FlhB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3161</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the type III secretion exporter family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513877.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3161"/>
    <dbReference type="EnsemblBacteria" id="ABB33374">
        <property type="protein sequence ID" value="ABB33374"/>
        <property type="gene ID" value="Gmet_3161"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3161"/>
    <dbReference type="eggNOG" id="COG2257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041013_4_1_7"/>
    <dbReference type="OMA" id="HEVPIYE"/>
    <dbReference type="OrthoDB" id="1823885at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006135">
        <property type="entry name" value="T3SS_substrate_exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029025">
        <property type="entry name" value="T3SS_substrate_exporter_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30531">
        <property type="entry name" value="PTHR30531"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01312">
        <property type="entry name" value="Bac_export_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160544">
        <property type="entry name" value="SSF160544"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="94" mass="10534" checksum="89C070AAF6F2A740" modified="2005-11-22" version="1">MDHSEREKKAVALSYREGQYAPQVVAKGHGVTAEAIIACAREAGVFVHESPALVSQLMQVDIDHYIPPELYRAVAELLAWLYWLEQEEGRDGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QW7</accession>
    <name>Q39QW7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513860.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3144"/>
    <dbReference type="DNASU" id="3740918"/>
    <dbReference type="EnsemblBacteria" id="ABB33357">
        <property type="protein sequence ID" value="ABB33357"/>
        <property type="gene ID" value="Gmet_3144"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3144"/>
    <dbReference type="eggNOG" id="COG0702">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_6_5_7"/>
    <dbReference type="OMA" id="FFNRFAA"/>
    <dbReference type="OrthoDB" id="1928091at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="1">
        <location>
            <begin position="7"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="294" mass="32626" checksum="4A421B0898FFCBCF" modified="2005-11-22" version="1">MKIFLTGGTGFIGGHVRKALLEAGHRIRLLVHRRHEGVEAGVEQAEGDVTRLDTFATAVEGCDATINLVGIIREFPGRGMTFDKLHVEATQNVVEAARRAGIRRHLQMSALGSRPNATSRYHQTKWRAEEEVRASGLEWTIFRPSIVFGPKDDFINKLAGYIRSYPAVPVIGDGKYRLQPVAADDVARCFVLALEKPETVGQAYELCGPDRISYNDLLDTIGRIVGKGHVPKVPNPLGIMKLVVPVMQGFSFFPITMDQITMLVEENICASPWPQVFGFDPECFELGIAKYLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R80</accession>
    <name>Q39R80_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TIM alpha/beta-barrel protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514343.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3029"/>
    <dbReference type="DNASU" id="3741225"/>
    <dbReference type="EnsemblBacteria" id="ABB33244">
        <property type="protein sequence ID" value="ABB33244"/>
        <property type="gene ID" value="Gmet_3029"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3029"/>
    <dbReference type="eggNOG" id="COG1082">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085089_0_0_7"/>
    <dbReference type="OMA" id="HPPSWLG"/>
    <dbReference type="OrthoDB" id="1007505at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="3">
        <location>
            <begin position="20"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="265" mass="30504" checksum="0472EE369829F83B" modified="2005-11-22" version="1">MRISLSTGTLFTFPLGKVMAIARDAGFDGVELIVNQDFQKVNCRTLIRELAEILPIHSMHAPFMPLDGWGSSIDSLKRCVELSADCGVQLVNFHPPSWMGFELGFWRWLYRVMDFQKEVGQGGVIVTLENMPWVGKRVRMNPHILSSTTKFIDFIQERNLFMTFDTTHMGSGKANFINDFYLCYNSGRIRNIHFSDYGHGREHLLPGHGILPLTRFLNHLRSTGYNDTLTLELSPEEFPRDERIIVESLREILSYLRKETEHPIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RE0</accession>
    <name>Q39RE0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2969"/>
    <dbReference type="EnsemblBacteria" id="ABB33184">
        <property type="protein sequence ID" value="ABB33184"/>
        <property type="gene ID" value="Gmet_2969"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2969"/>
    <dbReference type="eggNOG" id="ENOG5032Y3P">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166635_0_0_7"/>
    <dbReference type="OMA" id="AGKGDHR"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045397">
        <property type="entry name" value="DUF6516"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20126">
        <property type="entry name" value="DUF6516"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="106" mass="12219" checksum="314EEAC7D423D7AA" modified="2005-11-22" version="1">MLTTLIAVVTLSNMNAKLLLNERHIISENAFVEMVVWRVPSPLPGSAHGFKYRLALVVDEQCVLRYDNEAGKGDHKHLGEEEMPYSFTSPQDLLDDFWRDVDNRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RH5</accession>
    <name>Q39RH5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Menaquinol oxidoreductase complex Cbc5, cytochrome c subunit putative, HAMP domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbcD</name>
        <name evidence="4" type="ordered locus">Gmet_2931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512867.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2931"/>
    <dbReference type="EnsemblBacteria" id="ABB33149">
        <property type="protein sequence ID" value="ABB33149"/>
        <property type="gene ID" value="Gmet_2931"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2931"/>
    <dbReference type="eggNOG" id="COG2770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_982665_0_0_7"/>
    <dbReference type="OMA" id="KSTRYAM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="3">
        <location>
            <begin position="214"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="282" mass="30834" checksum="1F9FA213C674B8EA" modified="2005-11-22" version="1">MLKSFAAKATVPPAIAVTGFVVVCCILLYSVIKTDMLNDAIEHETNLAGTIVKSARYAMLKDDRETLRNIIDNIGQQKGVEHTRIFNKKGVIMFSAHTEDVNKLVDKKAAGCIACHTGPVPLTSMGRMEQARRYINEQGHSVIAITVPIYNEPDCFNAACHVHSPNLKLLGTLDIGLSEEPLQKTLGTLRGRMIVFCVMVLILTVGGVSALLLRNVLLPIKELANYVVAIKRGDANRKAPAYRDEIGELARSFEEMATRLTATQNESKQQRSAEGDGADSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RV1</accession>
    <name>Q39RV1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">D-fructose 6-kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mak</name>
        <name evidence="1" type="ordered locus">Gmet_2805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514679.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2805"/>
    <dbReference type="EnsemblBacteria" id="ABB33023">
        <property type="protein sequence ID" value="ABB33023"/>
        <property type="gene ID" value="Gmet_2805"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2805"/>
    <dbReference type="eggNOG" id="COG1940">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036604_0_3_7"/>
    <dbReference type="OMA" id="DHLVMIT"/>
    <dbReference type="OrthoDB" id="1130699at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000600">
        <property type="entry name" value="ROK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18964">
        <property type="entry name" value="PTHR18964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00480">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01125">
        <property type="entry name" value="ROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="297" mass="31106" checksum="7F9995D39CA74EA1" modified="2005-11-22" version="1">MNPYRIGIDLGGTKIEALLLGPEGEEQSRRRIPSPAVMGYEAVVAAVAGLVDEAAGRIPEGARRTIGIGIPGSVDPVTGLVRNANSTCLIGKPLQGDLESRLGCSVALRNDADCFTMAECRMGAGRGYGLVFGVIMGTGCGGGICIDGVVREGPHRIAGEWGHISVDPAGAPCYCGNRGCVETKISGSGVERAFCADHGEGIVMEEIVRLAREGEPRCTAAFDRFLDDFGRCLGGLISILDPDAVVLGGGLSNIDELYTIGVERVHRYAFHDALRTPILRNRLGDSAGVIGAAWIGR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RY8</accession>
    <name>GLGC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glucose-1-phosphate adenylyltransferase</fullName>
            <ecNumber evidence="1">2.7.7.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ADP-glucose pyrophosphorylase</fullName>
            <shortName evidence="1">ADPGlc PPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">ADP-glucose synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glgC</name>
        <name type="ordered locus">Gmet_2768</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate + ATP + H(+) = ADP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57498"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.27" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511693.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RY8"/>
    <dbReference type="SMR" id="Q39RY8"/>
    <dbReference type="STRING" id="269799.Gmet_2768"/>
    <dbReference type="PRIDE" id="Q39RY8"/>
    <dbReference type="EnsemblBacteria" id="ABB32986">
        <property type="protein sequence ID" value="ABB32986"/>
        <property type="gene ID" value="Gmet_2768"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2768"/>
    <dbReference type="eggNOG" id="COG0448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_14_1_7"/>
    <dbReference type="OMA" id="QEWDVDE"/>
    <dbReference type="OrthoDB" id="1557977at2"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008878">
        <property type="term" value="F:glucose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00624">
        <property type="entry name" value="GlgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011831">
        <property type="entry name" value="ADP-Glc_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005836">
        <property type="entry name" value="ADP_Glu_pyroP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023049">
        <property type="entry name" value="GlgC_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43523">
        <property type="entry name" value="PTHR43523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02091">
        <property type="entry name" value="glgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00809">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00810">
        <property type="entry name" value="ADP_GLC_PYROPHOSPH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword id="KW-0321">Glycogen metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000261872" description="Glucose-1-phosphate adenylyltransferase">
        <location>
            <begin position="1"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>alpha-D-glucose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00624"/>
        </source>
    </evidence>
    <sequence length="412" mass="46342" checksum="AAB1FF31BC53CE2C" modified="2005-11-22" version="1">MYVTGNLAGNTIAMVLAGGKGERLAPLTLRRPKPGVAFGGKYKIIDFVLSNMFNSGIKKVYILTQYRAYSLMKHIRESWGKWAGLGEFFVAISPETSSESEEWFKGTADAINHYLRFIESSDADYVAIFGGDHIYRMDVSQMIGYHRRNRADITIAALEVPVEEARRFGVFCVDDDNRVTAFEEKPANPVTIPGRETCFASMGNYIFSTRRLIEVLQEGKKLHADLDFGKHVIPMMLAKKDRVFAYNFNDNLIPGMKPEERGYWKDVGTIDSYYEANMELIHVSPQLNLYNYKWPILTNQGNYPPAKTVFDEDGRRGMNIDSYVCAGCITSGSVVRRSIVGPLTKVNSYSLVEDSILFENVNVGRNVKIRRAIIDKNITIPDGTTIGYDHGEDRRRGYTVTESGIVVVSPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RZ8</accession>
    <name>Q39RZ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511703.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2758"/>
    <dbReference type="EnsemblBacteria" id="ABB32976">
        <property type="protein sequence ID" value="ABB32976"/>
        <property type="gene ID" value="Gmet_2758"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2758"/>
    <dbReference type="eggNOG" id="ENOG502ZBPW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1599488_0_0_7"/>
    <dbReference type="OMA" id="RYYMGRR"/>
    <dbReference type="OrthoDB" id="1454720at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="168" mass="20308" checksum="D2E02C7FBC376F67" modified="2005-11-22" version="1">MDQIYVVVDDLMQRNYIYTLSEPVGMNFHPEFKPELTPREMLELGVFGGKYMTDCIDEFPEEWFTNAKLCHERHVPELNHFGVNASKPLSYWRARGWIYHEDPRGWFQWYCRYFMGRRCADDARQIGRWKAMRRHSAQLRLNCVPGDLDCRRKQRQALLHWAYDSRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S59</accession>
    <name>Q39S59_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcriptional response regulator LytT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">lytT</name>
        <name evidence="4" type="ordered locus">Gmet_2697</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2697"/>
    <dbReference type="EnsemblBacteria" id="ABB32915">
        <property type="protein sequence ID" value="ABB32915"/>
        <property type="gene ID" value="Gmet_2697"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2697"/>
    <dbReference type="eggNOG" id="COG3279">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_14_1_7"/>
    <dbReference type="OMA" id="THISART"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007492">
        <property type="entry name" value="LytTR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039420">
        <property type="entry name" value="WalR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48111">
        <property type="entry name" value="PTHR48111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04397">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00850">
        <property type="entry name" value="LytTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50930">
        <property type="entry name" value="HTH_LYTTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="HTH LytTR-type" evidence="3">
        <location>
            <begin position="134"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="240" mass="27345" checksum="2A9B0AE21A89AD55" modified="2005-11-22" version="1">MRVFIVDDEAPARRELRYLLERVEGVEVAGEAANGTEALKGIRQTRPQLVFLDIQMPGLSGLELAQFLAELPTRPLLVFATAFQEYALQAFEVEAFDYLLKPFDKERLEKTVMKAARALAPPAGREPGEPGRKIALYRGETIIPTAPERILFARSEGGEVVVHAGDGRYRTRFTLNELEQKLSPSGFVRVHRSFLVNTNHVREVVPWFHGSYKLIMDDREKSEIPVSRYNVKDLKRYFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S81</accession>
    <name>Q39S81_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3'-to-5' exonuclease YhaM</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yhaM</name>
        <name evidence="3" type="ordered locus">Gmet_2675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511786.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2675"/>
    <dbReference type="EnsemblBacteria" id="ABB32893">
        <property type="protein sequence ID" value="ABB32893"/>
        <property type="gene ID" value="Gmet_2675"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2675"/>
    <dbReference type="eggNOG" id="COG3481">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056349_2_0_7"/>
    <dbReference type="OMA" id="NLVGHLV"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDc" evidence="2">
        <location>
            <begin position="158"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="384" mass="43270" checksum="2C6F9C6A55FC6251" modified="2005-11-22" version="1">MNKVYVSSIKDRDQLESVFLVKDKIMAMAKNGKPYMTLKLMDKTGEIEGRVWDNVDELSAIFDRDDFVAIRCKASVYLGKMQLIISELVRVPDDRVQLADFLPESDRPVGEMEQELAVLLASFTDPHLKSLMDAFFGDAELMALYRIAPAAKGMHHVYLGGLLEHSLAVARLVDTIIPLYGGLNRDLLVAGALLHDVGKVREMTYQRSFDYTDEGKLLGHITIGVEMVQERIAAIPGFPTELAMLLKHMLLSHHGQYEYGSPKRPKTVEATILNYLDDLDSKINGIRTHIRKEAESQSRWSSYHRLYDRYFYKENYSCGEEYDEAAEAEAEGAAPEPPAQQPATAPESPAAPAPHPRGEEQKKKGFHNNPFEQLQGKNLDLFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SB0</accession>
    <name>Q39SB0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxymuconolactone decarboxylase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511816.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2646"/>
    <dbReference type="EnsemblBacteria" id="ABB32864">
        <property type="protein sequence ID" value="ABB32864"/>
        <property type="gene ID" value="Gmet_2646"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2646"/>
    <dbReference type="eggNOG" id="COG2128">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082760_4_2_7"/>
    <dbReference type="OMA" id="MRPNDEF"/>
    <dbReference type="OrthoDB" id="1925754at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004675">
        <property type="entry name" value="AhpD_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010195">
        <property type="entry name" value="Uncharacterised_peroxidase-rel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="SSF69118"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00778">
        <property type="entry name" value="ahpD_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01926">
        <property type="entry name" value="peroxid_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMD" evidence="1">
        <location>
            <begin position="44"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="176" mass="19085" checksum="014DD8A46D99869D" modified="2005-11-22" version="1">MARLTTVEVSAVSGETAAIFKEIEGAFGMVPNLFKSYAHHPPLLKANWNKVKAVMMEGTLSQKVKQTIAVLVSRDNGCTYCVAAHTGALKAIGISDEEIGIIMQSIEQADFSAKEKALIGFARKANTNPTRIEDAEFDALRQAGVSDAEIVEALGVMELFTAFNKFLDSLQVEIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SC0</accession>
    <name>Q39SC0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ATP-independent chaperone, alpha-crystallin/Hsp20 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2635</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the small heat shock protein (HSP20) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366078.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2635"/>
    <dbReference type="EnsemblBacteria" id="ABB32854">
        <property type="protein sequence ID" value="ABB32854"/>
        <property type="gene ID" value="Gmet_2635"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2635"/>
    <dbReference type="eggNOG" id="COG0071">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046737_12_4_7"/>
    <dbReference type="OMA" id="WEEMERW"/>
    <dbReference type="OrthoDB" id="1523369at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002068">
        <property type="entry name" value="A-crystallin/Hsp20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00011">
        <property type="entry name" value="HSP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="SSF49764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01031">
        <property type="entry name" value="SHSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SHSP" evidence="4">
        <location>
            <begin position="85"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="195" mass="22262" checksum="F576950360CC2BAE" modified="2005-11-22" version="1">MRRHTELRTMSHKDTGESVEPRRTTGSGTSHETKGITKSETEGSSREVSVLSPIREMERWFEESLSRPFFGMHWMPFRQMFSEVGERTELMPAVDMFEEGGHLVVKAELPGITKENLNLRIVDNNLILSGERSSEEKIERGNYLRLERSHGSFSRTLSLPDGLDTEHIKAGFKDGVLEVRIPRTESSTVREITVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SF1</accession>
    <name>Q39SF1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix transcriptional regulator, MerR family, PTSIIA domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511857.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2604"/>
    <dbReference type="EnsemblBacteria" id="ABB32823">
        <property type="protein sequence ID" value="ABB32823"/>
        <property type="gene ID" value="Gmet_2604"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2604"/>
    <dbReference type="eggNOG" id="COG1762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072531_1_1_7"/>
    <dbReference type="OMA" id="PHVRNPI"/>
    <dbReference type="OrthoDB" id="1770263at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00211">
        <property type="entry name" value="PTS_IIA_fru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041657">
        <property type="entry name" value="HTH_17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016152">
        <property type="entry name" value="PTrfase/Anion_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002178">
        <property type="entry name" value="PTS_EIIA_type-2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12728">
        <property type="entry name" value="HTH_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00359">
        <property type="entry name" value="PTS_EIIA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55804">
        <property type="entry name" value="SSF55804"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51094">
        <property type="entry name" value="PTS_EIIA_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PTS EIIA type-2" evidence="1">
        <location>
            <begin position="75"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="228" mass="25208" checksum="53D95EBBD94EE9AF" modified="2005-11-22" version="1">MLLEPSEAAQALNVDEKTIVRWIRKDNLPAESMHGDYRINPVDLLEWATERGIKVNPALYKMHDADTRPLPTLCQALQAGGIHCGFPGNDKETVLRNVVAALELPPQIDPEFILQVLLAREAMGTTAVGDGIAIPHVRNPILVQLPVPKISLSFLAQPVDFGALDGKPVQILFTIISPTIRMHLHLLSRLAYCLRDQRLRDILGKQCNARAIMDVILEIEKDIGSAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SK5</accession>
    <name>Q39SK5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AspT family membrane protein, TrkA-C domain pair-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAE transporter (TC 2.A.81) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513484.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2550"/>
    <dbReference type="EnsemblBacteria" id="ABB32769">
        <property type="protein sequence ID" value="ABB32769"/>
        <property type="gene ID" value="Gmet_2550"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2550"/>
    <dbReference type="eggNOG" id="COG0569">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2985">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035023_3_0_7"/>
    <dbReference type="OMA" id="AMWLIRL"/>
    <dbReference type="OrthoDB" id="1458740at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006512">
        <property type="entry name" value="YidE_YbjL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06826">
        <property type="entry name" value="Asp-Al_Ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01625">
        <property type="entry name" value="YidE_YbjL_dupl"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="189"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="7">
        <location>
            <begin position="275"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="546" mass="58149" checksum="C485DF3BC895E1D3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SL3</accession>
    <name>Q39SL3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2542</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2542"/>
    <dbReference type="EnsemblBacteria" id="ABB32761">
        <property type="protein sequence ID" value="ABB32761"/>
        <property type="gene ID" value="Gmet_2542"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2542"/>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="ADHFPDE"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="7"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="39"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="262" mass="29444" checksum="C1CA53350517DEE3" modified="2005-11-22" version="1">MTVERGIRMDQVSYAVGGRTILDRFDLFLEPGVNRTILGMSGAGKTTILRLMLGLLKPDGGTISIDGVSICGMRERQLIQVRKKIAIVFQGGALFDSMTVGENVGYRLFEEGRLSEKEIERIVLEKLSFVGLEQTIDLYPAELSGGMKKRVAIARGLAAEPEYIFFDEPTTGLDPVGVYNIRHLMLRLQGEGKTTLMVTHDLETAFAVSRRFSFLHHARLAFEGTEEEMRRCDTPEIREFLTPTDRSLFRYTTNNHTETTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SM8</accession>
    <name>Q39SM8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514526.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32746">
        <property type="protein sequence ID" value="ABB32746"/>
        <property type="gene ID" value="Gmet_2525"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2525"/>
    <dbReference type="HOGENOM" id="CLU_208449_0_0_7"/>
    <dbReference type="OMA" id="AGHMAII"/>
    <dbReference type="OrthoDB" id="2084350at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="62" mass="6802" checksum="9DD57D9777EA8690" modified="2005-11-22" version="1">MTHIETTRVNEVIGLHIGTIQETAQMLNVNCELQELEAHIATLEQAIADLKESLTAIPHGNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SP6</accession>
    <name>Q39SP6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rhomboid-related membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2506</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514641.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2506"/>
    <dbReference type="EnsemblBacteria" id="ABB32728">
        <property type="protein sequence ID" value="ABB32728"/>
        <property type="gene ID" value="Gmet_2506"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2506"/>
    <dbReference type="eggNOG" id="COG0705">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_061963_0_0_7"/>
    <dbReference type="OMA" id="ENRNWPP"/>
    <dbReference type="OrthoDB" id="2053476at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="SSF144091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Rhomboid" evidence="6">
        <location>
            <begin position="141"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="316" mass="33800" checksum="E5F6FDFFE5AB0657" modified="2005-11-22" version="1">MIRLSFMELETVHTALRQELWLPVAPGALEEGKAQLWGLVLESRAVPCRSVRSDNGWHVVVPASFYDRAVEEVRLFEEENRNWPPPAPPVRTMNGNVLATLSVLFLLATFHNITRLDVTLPGHPPLDWLALGSADAAKIMDGQWWRAVTALTLHANLPHLVSNLAIGGVLVILLCREIGSGLAWSLILGSGILGNLVNALLHSSGHISVGASTAVFGAVGILASSSVVRHRHHLQRRWPLPVAAGLALLAVLGTEGEHTDLGAHLFGFLWGIALGAVAEYLIGRFGQPGPVLNAVLAIASAVGVVFSWWVALAVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SU4</accession>
    <name>Q39SU4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Octaprenyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ispB</name>
        <name evidence="3" type="ordered locus">Gmet_2455</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512445.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2455"/>
    <dbReference type="EnsemblBacteria" id="ABB32680">
        <property type="protein sequence ID" value="ABB32680"/>
        <property type="gene ID" value="Gmet_2455"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2455"/>
    <dbReference type="eggNOG" id="COG0142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014015_2_0_7"/>
    <dbReference type="OMA" id="GKQMRPM"/>
    <dbReference type="OrthoDB" id="1861068at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="SSF48576"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="322" mass="35282" checksum="1E2F945CCFD9AF2F" modified="2005-11-22" version="1">MHSALALVGDDLKNVEAQFKKDLESDVYLIRKVGEYVLASGGKRIRPTLLLLAAKLCGYTGDRHVPLASVIEFIHTATLLHDDVVDNATLRRGNASANEVWGNEASVLVGDFLFSKSFSLMVQAGDLRVLKVISDATTIIAEGEVLQLLCTSDLDMTLERYIEVVKSKTAVLLSAACEAGAILGKATPEQELALRDFGMDLGIAFQLMDDTLDYTASEEQFGKEIGHDLEEGKITLPLIHTLRKCTDEERETIAAVVEKEVMEPGDFEAVFALVHKYGGIQYTTEVAGEYIARCKEHLQAFPASTEKQAALDLADYVVSRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SV5</accession>
    <name>Q39SV5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrous iron transport protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">feoB</name>
        <name evidence="14" type="ordered locus">Gmet_2444</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Probable transporter of a GTP-driven Fe(2+) uptake system.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512456.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2444"/>
    <dbReference type="EnsemblBacteria" id="ABB32669">
        <property type="protein sequence ID" value="ABB32669"/>
        <property type="gene ID" value="Gmet_2444"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2444"/>
    <dbReference type="eggNOG" id="COG0370">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013350_6_0_7"/>
    <dbReference type="OMA" id="YFPRLAL"/>
    <dbReference type="OrthoDB" id="304844at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055072">
        <property type="term" value="P:iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01879">
        <property type="entry name" value="FeoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003373">
        <property type="entry name" value="Fe2_transport_prot-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011640">
        <property type="entry name" value="Fe2_transport_prot_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030389">
        <property type="entry name" value="G_FEOB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07664">
        <property type="entry name" value="FeoB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02421">
        <property type="entry name" value="FeoB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00437">
        <property type="entry name" value="feoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51711">
        <property type="entry name" value="G_FEOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 12" id="KW-0410">Iron transport</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="603"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="FeoB-type G" evidence="13">
        <location>
            <begin position="21"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="663" mass="73014" checksum="8F0C307D7A9E5F88" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SZ2</accession>
    <name>Q39SZ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512493.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2407"/>
    <dbReference type="EnsemblBacteria" id="ABB32632">
        <property type="protein sequence ID" value="ABB32632"/>
        <property type="gene ID" value="Gmet_2407"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2407"/>
    <dbReference type="eggNOG" id="COG1136">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="PTRGHID"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03255">
        <property type="entry name" value="ABC_MJ0796_LolCDE_FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017911">
        <property type="entry name" value="MacB_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="9"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="231" mass="24873" checksum="08643980400679F5" modified="2005-11-22" version="1">MAETTPPIVAVRNLSKSYRRGQQIVPVLQDISFDIAPGEFLALMGPSGSGKSTLLNLIAGIDKADSGTITIGGVEISTLPEAELAAWRAGNVGFIFQFYNLIPVLTAFENVELPLLLTGLTRRERREHVETVLSLVGLADRIDHYPSQLSGGQQQRVAIARAMVTDPEILVADEPTGDLDRVSAGEILALMERLVSGFGKTIIMVTHDPRAAEQAHRLLHLEKGELTDGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T26</accession>
    <name>Q39T26_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="4 8">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_2373</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate = ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="8">Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NAPRTase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="4 8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513247.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2373"/>
    <dbReference type="EnsemblBacteria" id="ABB32598">
        <property type="protein sequence ID" value="ABB32598"/>
        <property type="gene ID" value="Gmet_2373"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2373"/>
    <dbReference type="eggNOG" id="COG1488">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025154_2_1_7"/>
    <dbReference type="OMA" id="VYFPGSP"/>
    <dbReference type="OrthoDB" id="241792at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041619">
        <property type="entry name" value="NAPRTase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006405">
        <property type="entry name" value="Nic_PRibTrfase_pncB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="PTHR11098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17956">
        <property type="entry name" value="NAPRTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01513">
        <property type="entry name" value="NAPRTase_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 8" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NAPRTase_N" evidence="10">
        <location>
            <begin position="6"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase" evidence="9">
        <location>
            <begin position="152"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="NAPRTase_C" evidence="11">
        <location>
            <begin position="355"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="476" mass="52078" checksum="9618C63CC63F7428" modified="2005-11-22" version="1">MSYSPLLTDLYQLTMLAGYLEEGMADKPAVFDIFFRHNPFQGGYAVFAGLDTALGYLENLQFTEDDLEYLQGLEIFRPRFIDFLRSFRFRGKVTAPPEGTVVFANEPLVTIEAPLAQAQLVETALLNIINFQTLVATKGARIVHAAVDGTVLEFGLRRAQGPDGGVSEARAAYIGGVRSTSNVLAGKLFGIPVKGTHAHSWIMAFPDELTAFRAYAEVFPDTCILLVDTYDTLKSGIPNAITVAQELRSQGHELVGVRIDSGDLAYLSREGRRMFDEAGFPGVKIVASNELDEYVIESMRSEGGRVDIYGVGTRLATCAGEGGGALGGVYKLVRIGDRPKLKVTSDVAKATLPDRKRLLRAVAPDGSFIQDVLCLADEDIAPGATVYDPSNPLQFVAIPQQARFVEIRGVVMEDGVRTAKSPPSLDEMADRSRDQLTRLPQGCMRFINPHKYKVSISAGLNELRLQLMDEVQRGYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T31</accession>
    <name>Q39T31_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">CBS and CorC_HlyC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2368</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513252.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2368"/>
    <dbReference type="EnsemblBacteria" id="ABB32593">
        <property type="protein sequence ID" value="ABB32593"/>
        <property type="gene ID" value="Gmet_2368"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2368"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_3_0_7"/>
    <dbReference type="OMA" id="QMISIKA"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="67"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="4">
        <location>
            <begin position="132"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="284" mass="32180" checksum="48BFB498527C154E" modified="2005-11-22" version="1">MDEGSGRKSAGLMDMFGRFLTGKKRITEEEIQDIIDASEEEGLINPEENEMIRSIFELRDTVVREIMVPRTDMACVSADTSVGEVLRTIITCGHSRIPVYDGTVDNIIGLIYAKDLLKYWGMGDSSINIRRIMRTPYFIPESKNLEELLQEFKRKRVHIAIVIDEYGGTSGLVTIEDLLEQIVGDIQDEYDLEEDWIVEEPDGSVLVDARLPIEDLEERFGIEIEREKFDTVAGLIFHLTGRIPKVGEEIENDALRMTVLEGGERNIRKVRVARRAGASEETEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T35</accession>
    <name>Q39T35_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2364</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513256.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2364"/>
    <dbReference type="EnsemblBacteria" id="ABB32589">
        <property type="protein sequence ID" value="ABB32589"/>
        <property type="gene ID" value="Gmet_2364"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2364"/>
    <dbReference type="eggNOG" id="COG4198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031277_0_0_7"/>
    <dbReference type="OMA" id="IYIADGH"/>
    <dbReference type="OrthoDB" id="591335at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008323">
        <property type="entry name" value="UCP033563"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36454">
        <property type="entry name" value="PTHR36454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06245">
        <property type="entry name" value="DUF1015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033563">
        <property type="entry name" value="UCP033563"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="413" mass="46299" checksum="F45276F61D692C47" modified="2005-11-22" version="1">MALIKPFRALRPPKSLAEKVAALPYDVMNVEEAKAMAAGNPYSFLHVSRPEIDLPAEVDPYAEEVYVKGRENMQRFIAEGTLILDRDECYYVYRQRMGAIEQTGLVVCAGVDDYESGVIKKHELTRADKEEDRVRHIDYLDANDEPVFYTYRNDPAITAIVAGVAAGEPTYHFTTDDGVIHTLWIISDRAVIDDLTTRFAAIETLYVADGHHRSAAAGRVRELRRAANPGHTGNEEYNWFLTVIFPDSEMNIMPYNRAVKDLNGHSVAELMARIGERFAITPATGGFAPSQRHEFGMYLEGRWYQLVAKEGTFDEGDAVSHLDVSILQNNLLSPILAIRNPRTDQRISFVGGIRGTDELERLVDGGGYRIAFSLNPTSMEELMQLADAGQIMPPKSTWFEPKLRSGLFVHQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T61</accession>
    <name>Q39T61_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane-bound O-acyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_2338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the membrane-bound acyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513282.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2338"/>
    <dbReference type="EnsemblBacteria" id="ABB32563">
        <property type="protein sequence ID" value="ABB32563"/>
        <property type="gene ID" value="Gmet_2338"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2338"/>
    <dbReference type="eggNOG" id="COG1696">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025255_1_1_7"/>
    <dbReference type="OMA" id="IIWGAWH"/>
    <dbReference type="OrthoDB" id="1297594at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042121">
        <property type="term" value="P:alginic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024194">
        <property type="entry name" value="Ac/AlaTfrase_AlgI/DltB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028362">
        <property type="entry name" value="AlgI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500217">
        <property type="entry name" value="AlgI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016636">
        <property type="entry name" value="AlgI_DltB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="358"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR016636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="491" mass="55925" checksum="4A3B55CFCE15FA82" modified="2005-11-22" version="1">MLFNSYEFILAFLPVTLLLYYLLNGKRLAVAANSWLLFASLFFYGWWDIKYVPLILGSILFNYTIGSLLSDGAGARKGVSRRAIFVFGIVANLLLLGFFKYVDFFITNVNSALDAGLPLLRIVLPLGISFFTITQIAFLVDAYEGLVEERNLLNYALFVTFFPHLLAGPILHHSDMMPQFASLRTKVLRYRNVYLGILLFSMGLFKKVVLADRFSEWATAGFDKAGTLTFVEAWLASLSYTFQLYFDFSGYSDMAIGIGLLFNIRLPVNFNSPYKARSIIDFWKRWHITLTEFITTYVYTPILRSFGSITFANSLAAIFVAMLISGFWHGAGWTFILWGCLHGTALVLNHYWKKRKWWMHPALGWFLTFNFANLSFVFFRAKEWHDATKVLAGMFGVNGLMLNHSLAKIPLLAKLGEWGVQFGPWLQGIDGKDETWISVALAFPFILLAKNSNEIAEMLKPSWKSCTLAIVTFAWALMSMSTVSEFLYFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T67</accession>
    <name>Q39T67_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">dTDP-4-dehydro-6-deoxyglucose aminotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2332</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DegT/DnrJ/EryC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513288.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2332"/>
    <dbReference type="EnsemblBacteria" id="ABB32557">
        <property type="protein sequence ID" value="ABB32557"/>
        <property type="gene ID" value="Gmet_2332"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2332"/>
    <dbReference type="eggNOG" id="COG0399">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033332_1_1_7"/>
    <dbReference type="OMA" id="IHTQIHY"/>
    <dbReference type="OrthoDB" id="1722208at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00616">
        <property type="entry name" value="AHBA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000653">
        <property type="entry name" value="DegT/StrS_aminotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30244">
        <property type="entry name" value="PTHR30244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01041">
        <property type="entry name" value="DegT_DnrJ_EryC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000390">
        <property type="entry name" value="PLP_StrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000390-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="404" mass="44747" checksum="294CC512A86FF674" modified="2005-11-22" version="1">MKLKTSCDELAVMGGSPAFSDTLHVGRPNIGDRSEFLERVNGILDRRWLTNNGICVQEFERRLEALLGVKHCIAMCNATVALEITIRALGMTGEVIVPSFTFVATPHSLQWQQITPVFCDIDPETHSIDPRRVESLITPRTTGIIGVHLWGKPCKIEALAEIAGRRNLRLLFDAAHAFGCSHNGRMIGSFGDAEVFSFHATKFFNTFEGGAVATNDDDLAARIRLMKNFGFAGYDNVVYIGTNGKMSEISAAMGLTSLDHLEEIITINRRNYAAYASGLANVQGIRLVPYEGADRYNYQYVVLEVDEQAAGIHRDMLLQALHAENIMARRYFYPGCHRMEPYRSYFPNAGMLLPETERLAERVLSLPTGTAVSEEDIVDICSIIRLVLKNGVEVTNALANGKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TG8</accession>
    <name>Q39TG8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase, AMP-forming</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2229"/>
    <dbReference type="EnsemblBacteria" id="ABB32456">
        <property type="protein sequence ID" value="ABB32456"/>
        <property type="gene ID" value="Gmet_2229"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2229"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_7"/>
    <dbReference type="OMA" id="ECTAPCA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="417"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="513" mass="56775" checksum="C1C31392C00F0F85" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TP4</accession>
    <name>Q39TP4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">bamQ</name>
        <name evidence="5" type="ordered locus">Gmet_2151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513054.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2151"/>
    <dbReference type="EnsemblBacteria" id="ABB32380">
        <property type="protein sequence ID" value="ABB32380"/>
        <property type="gene ID" value="Gmet_2151"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2151"/>
    <dbReference type="eggNOG" id="COG1064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026673_20_1_7"/>
    <dbReference type="OMA" id="YCDGGYS"/>
    <dbReference type="OrthoDB" id="1859760at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017614">
        <property type="entry name" value="Dearomat_deydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="SSF50129"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03201">
        <property type="entry name" value="dearomat_had"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ADH_N" evidence="4">
        <location>
            <begin position="30"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="ADH_zinc_N" evidence="3">
        <location>
            <begin position="183"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="357" mass="37768" checksum="3F6199C7EE88E58E" modified="2005-11-22" version="1">MSTAPHRWTMTAVGEPMVKADFDAAPPSDNEVVVEVAGCGVCHTDLGFYYDGVRVNHGLPLTLGHEISGRVVATGKGAEAWQGKAVLIPAVIPCGVCDLCLSGHGTICRTQQMPGNDIQGGFATHIKVPARGLCPVDEKKLAAAGFELADISVVADAVTTPYQAVVQAEVQKGDLAIVIGIGGVGSYAVQIANAMGATVVAIDVDQAKLDNMAKYGAGLTINSRQVQGKDLKKAIQTFVKEKGLPQTCWKIFECSGTVPGQDTAFGLLTFGATLSVVGFTMDKIELRLSNLMAFHARALGNWGCLTELYPAALDLVLEKKIALAPFIEKHPLEKINEIFEAAHAHKLTRRAILVPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TP5</accession>
    <name>Q39TP5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclohexa-1,5-dienecarbonyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bamR</name>
        <name evidence="2" type="ordered locus">Gmet_2150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513055.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2150"/>
    <dbReference type="EnsemblBacteria" id="ABB32379">
        <property type="protein sequence ID" value="ABB32379"/>
        <property type="gene ID" value="Gmet_2150"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2150"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_3_7"/>
    <dbReference type="OMA" id="LEFARPH"/>
    <dbReference type="OrthoDB" id="1114675at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017602">
        <property type="entry name" value="Dienoyl_CoA_hydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03189">
        <property type="entry name" value="dienoyl_CoA_hyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="256" mass="27138" checksum="CB95CA919E5078A8" modified="2005-11-22" version="1">MSESPLKVWLEKDGALLRLRLARPKANIVDAAMIAALQAALTEHLPSAKLRAVLLDAEGPHFSFGASVEEHMPESCAAMLQSLHALVIQMLESPVPVLVAVRGQCLGGGLEVVAAGNLIFAAPGAMLGQPEIKIGVFAPAASCLLPERIGKTASEDLLFSGRSITAEEGFRIGLVTAVAEDPEQAAVAYFDEHLAGLSASSLRFAVRAARIGVLERTKTKIAAVEKLYLEELMATHDAVEGLNAFLGKRPAAWQDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TP8</accession>
    <name>Q39TP8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metal-dependent hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bamU</name>
        <name evidence="3" type="ordered locus">Gmet_2147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513058.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2147"/>
    <dbReference type="EnsemblBacteria" id="ABB32376">
        <property type="protein sequence ID" value="ABB32376"/>
        <property type="gene ID" value="Gmet_2147"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2147"/>
    <dbReference type="eggNOG" id="COG2159">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044590_4_0_7"/>
    <dbReference type="OMA" id="ICQQKGN"/>
    <dbReference type="OrthoDB" id="1832218at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="PTHR21240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydro-rel" evidence="2">
        <location>
            <begin position="15"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="286" mass="32148" checksum="32EE733388F9F7BF" modified="2005-11-22" version="1">MAHEMRDGSSRGLRIDFHVHLGVYADHKPWVTEWIKQSQPDPGEYDAYIERYSDPGAFEELLAAEGVDYACVLAELCPITTGICSNEQVEAFCKGRKRLIPFCSINPHLTTDLGGELRRLVETEGFRGLKLYPSYQHYYLNDPRVYPLYQAAQELGIPVLIHTGSSVFKGTRIKYCDPIHLDDVANDFPSLNLVMAHSGRGFWYDRAFFLSKLHSNLYMEVSGLPPSKLMTYFPELARNTDKVIFGSDWPGASQIKRNMDAIGALPLPAEGVEKILGGNAARLLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TV0</accession>
    <name>Q39TV0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">moaA-3</name>
        <name evidence="12" type="synonym">moaA</name>
        <name evidence="14" type="ordered locus">Gmet_2095</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513109.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2095"/>
    <dbReference type="EnsemblBacteria" id="ABB32324">
        <property type="protein sequence ID" value="ABB32324"/>
        <property type="gene ID" value="Gmet_2095"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2095"/>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_7"/>
    <dbReference type="OMA" id="FRHMSVT"/>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="6"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="326" mass="36110" checksum="967F19142ACD8B47" modified="2005-11-22" version="1">MSPSDIYGRKINYLRLSVTDRCNLRCTYCMPASGIKKRAHSDILSYEQLHRIAEAAVAIGVEKIRITGGEPLVRKGMPGFLAGLKRIPGLKKLVLTTNGVFLGSMAGELRDAGVESVNISLDSLRPEVFSRITRRGDLSKVLEGIAAAEHAGFEHIKLNMVVMRGVNDAEVLDFAALTLDRPLKVRFIEYMPTLKERNWQSFMVPGDELLSRLSKRYPLRKVTNDALDGPAVYYRIDGAAGTLGFITPMSSHFCQNCNRIRVTSSGTVKSCLFDDGKTSLKPYLENGDDAGLRETLRQVAGTKPHRHMFMSREADNHSFTMSQIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TY4</accession>
    <name>Q39TY4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Sodium/solute symporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_2061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514042.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2061"/>
    <dbReference type="EnsemblBacteria" id="ABB32290">
        <property type="protein sequence ID" value="ABB32290"/>
        <property type="gene ID" value="Gmet_2061"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2061"/>
    <dbReference type="eggNOG" id="COG0591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_22_1_7"/>
    <dbReference type="OMA" id="HIKDAMW"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006814">
        <property type="term" value="P:sodium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018212">
        <property type="entry name" value="Na/solute_symporter_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00457">
        <property type="entry name" value="NA_SOLUT_SYMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="7" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4" id="KW-0769">Symport</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="198"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="509"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="671" mass="73918" checksum="2E0C1EA9BAA9178D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TZ4</accession>
    <name>Q39TZ4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA-binding protein Hfq</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">hfq</name>
        <name evidence="2" type="ordered locus">Gmet_2051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Hfq family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514053.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2051"/>
    <dbReference type="EnsemblBacteria" id="ABB32280">
        <property type="protein sequence ID" value="ABB32280"/>
        <property type="gene ID" value="Gmet_2051"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2051"/>
    <dbReference type="eggNOG" id="COG1923">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113688_3_0_7"/>
    <dbReference type="OMA" id="QQMVYKH"/>
    <dbReference type="OrthoDB" id="1989988at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01716">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00436">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005001">
        <property type="entry name" value="Hfq"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34772">
        <property type="entry name" value="PTHR34772"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17209">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="SSF50182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02383">
        <property type="entry name" value="Hfq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0346">Stress response</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="74" mass="8510" checksum="80797678E58639AC" modified="2005-11-22" version="1">MAKAPFNIQDQYLNQSRKERIKVAVRLMSGEKLEGYIKSFDNFSVLMEIQGDMLIYKHAISSITSVDGTFKLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U17</accession>
    <name>Q39U17_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein tyrosine kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2028</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512922.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2028"/>
    <dbReference type="EnsemblBacteria" id="ABB32257">
        <property type="protein sequence ID" value="ABB32257"/>
        <property type="gene ID" value="Gmet_2028"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2028"/>
    <dbReference type="eggNOG" id="COG0489">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052027_1_1_7"/>
    <dbReference type="OMA" id="NPVSEQF"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005702">
        <property type="entry name" value="EPS_synthesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01007">
        <property type="entry name" value="eps_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0829">Tyrosine-protein kinase</keyword>
    <feature type="domain" description="AAA_31" evidence="7">
        <location>
            <begin position="88"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="283" mass="31491" checksum="9711B0A5CFE7404E" modified="2005-11-22" version="1">MSRIESILEKAAKMRQDKTPGESRVLVEQREVPRAVIEPEVFQPDTRIAVDNPYLVTISEPRSPVTEEYRKLKSIILKLTNSGQFKNTIMVTSAVSGEGKTITSINLAVALAQEFDHTVLLVDADLRRPGTSSYLGIRAEVGLSDCLYGKVDVKDALVKTGIGKLVVLPAGSRVENPVELLSSGRMQSFIAEIKNRYPDRYIIIDTPPLLSFAETYSLANMVDGVVFVVKEGGATMSNVKDALGHLKKEKVYGVVYNNVGINRFDENYRYRNYYAYYKDNGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UB8</accession>
    <name>Q39UB8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transport protein, Tim44-like domain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511916.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1927"/>
    <dbReference type="DNASU" id="3738111"/>
    <dbReference type="EnsemblBacteria" id="ABB32156">
        <property type="protein sequence ID" value="ABB32156"/>
        <property type="gene ID" value="Gmet_1927"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1927"/>
    <dbReference type="eggNOG" id="COG4395">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066429_0_0_7"/>
    <dbReference type="OMA" id="WKLAAIQ"/>
    <dbReference type="OrthoDB" id="1536134at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223405" evidence="3">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="Tim44" evidence="4">
        <location>
            <begin position="177"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="322" mass="35340" checksum="B606BF456ACEC67C" modified="2005-11-22" version="1">MKKQWITTIFTLTFAVSLVAAAYHEAEARAGGGRSFGSRGSRTYSAPSRTVNPYQSRPQASPTSPQQPFPQAQPQRQGGSFLRGLAGGVLGGLLGGMLFRSLGFAGPGAGGIGIFDILLIGGVLYLIYRFVASRRRETAQTSGYGAQQTWRQAESVEPPPRQYGFGQTAQAAPVDETSFGLAHVRQMDGSFDENRFKETAQDIFFRVQGAWTRRDLSPVADLLTPEMQVTFRQQIDELKAAGTINRLENISVREVNITEAWQEEGRDYLTVRLLASILDYTTDESGKVVSGSDSAPVKFEEYWTFSRPVGPNPWKLSAIQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UJ4</accession>
    <name>Q39UJ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1851</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1851"/>
    <dbReference type="EnsemblBacteria" id="ABB32080">
        <property type="protein sequence ID" value="ABB32080"/>
        <property type="gene ID" value="Gmet_1851"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1851"/>
    <dbReference type="eggNOG" id="COG5164">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036481_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008965">
        <property type="entry name" value="CBM2/CBM3_carb-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002989">
        <property type="entry name" value="Mycobac_pentapep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01469">
        <property type="entry name" value="Pentapeptide_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49384">
        <property type="entry name" value="SSF49384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="551" mass="56667" checksum="1F22654F9DA5568B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UM9</accession>
    <name>Q39UM9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SseB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512029.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1816"/>
    <dbReference type="EnsemblBacteria" id="ABB32045">
        <property type="protein sequence ID" value="ABB32045"/>
        <property type="gene ID" value="Gmet_1816"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1816"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1832308_0_0_7"/>
    <dbReference type="OMA" id="SKQFHPE"/>
    <dbReference type="OrthoDB" id="1673675at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009839">
        <property type="entry name" value="SseB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07179">
        <property type="entry name" value="SseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SseB" evidence="1">
        <location>
            <begin position="4"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="148" mass="16640" checksum="FD9ABAFF02A594CE" modified="2005-11-22" version="1">MTQLDEALVTLRQDMRDAKNQSKFYDLFLNSTFFVPILDEQSLAEVVEAPQDGQVLPLVIEAEGNDYLMLFDTRERLQAWTQTDAKSVEVPGHVLAATTMPPLHWALNTGTEYSKQFHPEEIAWLRDAVERCNAEAAGRGDSSKGEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UN9</accession>
    <name>Q39UN9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512040.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1806"/>
    <dbReference type="EnsemblBacteria" id="ABB32035">
        <property type="protein sequence ID" value="ABB32035"/>
        <property type="gene ID" value="Gmet_1806"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1806"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039068_9_1_7"/>
    <dbReference type="OMA" id="DVYARNP"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="44"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="228" mass="24176" checksum="770960DAB5E92661" modified="2005-11-22" version="1">MNGTALNWLELCRTVGPCLRPGGTALTDRALEVCNLSADSLIADVGCGAGGTLYHLEQIGFRRLVGLDPSETLLGDAAPRLETARLIRGEAATIPLRSATVDLLLCECVLSVLPGRSAPLREFARVVKDGGYLVVSDVFSTAGDEATGQAGGLLTRKELLAAVAGNGFTLLRWETHDRLLKEFAVRMILAGECLPDAWKGGTERKGEAARGGLGYFLMVARKAEDPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UT2</accession>
    <name>Q39UT2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ketose-1,6-bisphosphate aldolase, class II, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1761</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513343.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1761"/>
    <dbReference type="EnsemblBacteria" id="ABB31992">
        <property type="protein sequence ID" value="ABB31992"/>
        <property type="gene ID" value="Gmet_1761"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1761"/>
    <dbReference type="eggNOG" id="COG0191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_653212_0_0_7"/>
    <dbReference type="OMA" id="WKVPVDF"/>
    <dbReference type="OrthoDB" id="724051at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000771">
        <property type="entry name" value="FBA_II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01116">
        <property type="entry name" value="F_bP_aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="361" mass="39942" checksum="A91C7059526A7854" modified="2005-11-22" version="1">MINDLLELVPPRIRNKIGSQSRICLLNGRDLFSALKNENLILMACNPRIKHVIPGIMKAAEELDAVIAFELTRTEGGLNGGYTGQTPQVFFDTVIECAERYKFTKPFIIHGDHTTVQNTSPEEQERARLLIEGQVKAGYTSFAIDASFNPLPDNIRITAELAATVENEGYGLEVELGEVKRAGVESNLTTVEETQEFLSCLVKKGIHPQLLAIDNGSKRGNYLDGEMIRIDLDRTKEIYDAAVRLGLAGLVQHGITGTPLRLVGKLANYGIRKGNIGTLWQNVAHAGLPLDLMDAMRHWARENGKDIKFATKIFKSEIDAIPEENAKQIFDMAYREAKEFLQAFHAKGSASRLAASIGKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UW2</accession>
    <name>Q39UW2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1731</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513372.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1731"/>
    <dbReference type="EnsemblBacteria" id="ABB31962">
        <property type="protein sequence ID" value="ABB31962"/>
        <property type="gene ID" value="Gmet_1731"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1731"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_1_4_7"/>
    <dbReference type="OMA" id="EFTFDHH"/>
    <dbReference type="OrthoDB" id="2089619at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041474">
        <property type="entry name" value="NicS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17938">
        <property type="entry name" value="TetR_C_29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="2">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="199" mass="22347" checksum="25B740E700AEEC52" modified="2005-11-22" version="1">MTRPDCRSKLMEVGTQLFAERGLNGVSIRELSHGAGASISMVSYYFGGKEGLYSAVLQEQFACFDQIGEIMEQHAGPVDKIEAYIRWTIQRHRNNPHLLRFYTSELTNPTSYFPRIVAPAIGKVIRILVKVVEEGIREGVFRQDAHAVNAALALAGMVNYYFLSTLATEDLISHSPEQDEQLIHQYREIFTRGILAPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UX3</accession>
    <name>Q39UX3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aminopeptidase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513383.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1720"/>
    <dbReference type="EnsemblBacteria" id="ABB31951">
        <property type="protein sequence ID" value="ABB31951"/>
        <property type="gene ID" value="Gmet_1720"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1720"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_10_0_7"/>
    <dbReference type="OMA" id="ANMARTF"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="10"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="139"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="389" mass="42822" checksum="F3321B8C59610531" modified="2005-11-22" version="1">MMTKMESEQRIIRLQTELRAKGIDGALIIFPIDVYYFTGTRQNATLWVPADGNPLLLVRKSYSRAVKESLIEDTRPFPSSKEFPTLFSEDVKKVGLTFDIIPVQQYNYYAKMLPGRELVDISGINRELRSVKSAWELDRLRECGARLCEVFTQVPTFLKVGMREIDLAAEFECRLRKAGSEGYIRMRAFNQELFQGLAVSGATAAEPGFFDGAVTGRGLSNASPYGASTETITPGTPILLDFAGIFKGYLVDMTRIFVIGSLSSELEHAFATSLRIHQYLVENLKPGTICEELFARSLEMAEAAGLGRNYMGAPGENAKFVGHGVGLELDEFPVLAQGFKVPLQAGQTIAIEPKFVIPGQGVIGIENTFAVTSRGGEKLTSMADDIVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V20</accession>
    <name>Q39V20_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1673</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365858.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1673"/>
    <dbReference type="EnsemblBacteria" id="ABB31904">
        <property type="protein sequence ID" value="ABB31904"/>
        <property type="gene ID" value="Gmet_1673"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1673"/>
    <dbReference type="eggNOG" id="ENOG502ZD47">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2879469_0_0_7"/>
    <dbReference type="OMA" id="TELTKCH"/>
    <dbReference type="OrthoDB" id="2076019at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="63" mass="7463" checksum="D1926BD974A36386" modified="2005-11-22" version="1">MNRNETAFELWRQDDNGNRFLVGTFPNRAAAERQLTALTRVQHKQIYWIAECQIMKPQEAPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V31</accession>
    <name>Q39V31_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antibiotic biosynthesis monooxygenase domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511401.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1662"/>
    <dbReference type="EnsemblBacteria" id="ABB31893">
        <property type="protein sequence ID" value="ABB31893"/>
        <property type="gene ID" value="Gmet_1662"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1662"/>
    <dbReference type="eggNOG" id="COG1359">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_131496_11_1_7"/>
    <dbReference type="OMA" id="YMREAFD"/>
    <dbReference type="OrthoDB" id="1909149at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007138">
        <property type="entry name" value="ABM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03992">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="SSF54909"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51725">
        <property type="entry name" value="ABM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABM" evidence="1">
        <location>
            <begin position="3"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="94" mass="10927" checksum="D36BA88FB920D2A5" modified="2005-11-22" version="1">MAVTVVAKVVVKKEFIEPVKAELLKLVDPTRRERGCMEYRLHQDNEDPGVFIFYENWESMASLEQHMNSDHFRNYVSAVEGRLVKKVVNKMTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="52" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V81</accession>
    <name>Q39V81_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1612"/>
    <dbReference type="EnsemblBacteria" id="ABB31843">
        <property type="protein sequence ID" value="ABB31843"/>
        <property type="gene ID" value="Gmet_1612"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1612"/>
    <dbReference type="HOGENOM" id="CLU_3168533_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="47" mass="5433" checksum="CE3AE64412932B79" modified="2005-11-22" version="1">MGRYIRETRTPKEKLQDTVNTAIAFVLMIVAAALIVLLVFLFYENMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VF0</accession>
    <name>Q39VF0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">(R)-benzylsuccinate synthase, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">bssC</name>
        <name evidence="1" type="ordered locus">Gmet_1540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511526.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1540"/>
    <dbReference type="EnsemblBacteria" id="ABB31774">
        <property type="protein sequence ID" value="ABB31774"/>
        <property type="gene ID" value="Gmet_1540"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1540"/>
    <dbReference type="eggNOG" id="ENOG5033HQX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2896712_0_0_7"/>
    <dbReference type="OMA" id="CKNCSFY"/>
    <dbReference type="OrthoDB" id="2060072at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.90.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013161">
        <property type="entry name" value="BssC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038640">
        <property type="entry name" value="BssC_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08201">
        <property type="entry name" value="BssC_TutF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="57" mass="6287" checksum="BEE0D79C3883BB80" modified="2005-11-22" version="1">MTTCKNCSFYFAVPENAGDFEAGKGDCVIEKEDAKGKYWLSKPTRNDSPSCKAFKTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VF4</accession>
    <name>Q39VF4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">VWFA superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511530.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1536"/>
    <dbReference type="EnsemblBacteria" id="ABB31770">
        <property type="protein sequence ID" value="ABB31770"/>
        <property type="gene ID" value="Gmet_1536"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1536"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_478796_0_0_7"/>
    <dbReference type="OMA" id="TERCEYR"/>
    <dbReference type="OrthoDB" id="388498at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="569" mass="64253" checksum="E746265A34ABDBA1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VF8</accession>
    <name>Q39VF8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic nucleotide-binding domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1532</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="submission" date="2010-03" db="PDB data bank">
            <title>Crystal structure of a Putative Cyclic nucleotide-binding protein (Gmet_1532) from Geobacter metallireducens GS-15 at 1.90 A resolution.</title>
            <authorList>
                <consortium name="Joint Center for Structural Genomics (JCSG)"/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) IN COMPLEX WITH SUCCINATE</scope>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511534.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="3MDP">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=1-141"/>
    </dbReference>
    <dbReference type="PDBsum" id="3MDP"/>
    <dbReference type="SMR" id="Q39VF8"/>
    <dbReference type="STRING" id="269799.Gmet_1532"/>
    <dbReference type="DNASU" id="3740132"/>
    <dbReference type="EnsemblBacteria" id="ABB31766">
        <property type="protein sequence ID" value="ABB31766"/>
        <property type="gene ID" value="Gmet_1532"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1532"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075053_15_1_7"/>
    <dbReference type="OMA" id="CLRGKCE"/>
    <dbReference type="OrthoDB" id="1596937at2"/>
    <dbReference type="EvolutionaryTrace" id="Q39VF8"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Succinate</name>
            <dbReference type="ChEBI" id="CHEBI:15741"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Succinate</name>
            <dbReference type="ChEBI" id="CHEBI:15741"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>Succinate</name>
            <dbReference type="ChEBI" id="CHEBI:15741"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Succinate</name>
            <dbReference type="ChEBI" id="CHEBI:15741"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Succinate</name>
            <dbReference type="ChEBI" id="CHEBI:15741"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3MDP"/>
        </source>
    </evidence>
    <sequence length="141" mass="15220" checksum="7D42DCB440EB99A2" modified="2005-11-22" version="1">MISPERLRVYRFFASLTDEQLKDIALISEEKSFPTGSVIFKENSKADNLMLLLEGGVELFYSNGGAGSAANSTVCSVVPGAIFGVSSLIKPYHYTSSARATKPVRVVDINGARLREMSENNQALGQVLMNNVAAAVLARLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VJ2</accession>
    <name>Q39VJ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, WbnK-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365835.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1498"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="DNASU" id="3741629"/>
    <dbReference type="EnsemblBacteria" id="ABB31732">
        <property type="protein sequence ID" value="ABB31732"/>
        <property type="gene ID" value="Gmet_1498"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1498"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_7"/>
    <dbReference type="OMA" id="ISIMEAM"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="14"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="180"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="373" mass="41413" checksum="ED90BE19370BDC3F" modified="2005-11-22" version="1">MPMNIVQVIPSFNVGGGELLAVRLCAEIKNQRPDYKVTLISLYDPIPSIVYDEALASDAQIVTLGKKKGFDPFTPLRMLKTLRAIKPDVIHTHLAGLRYTLLAGVLGNYSLKVHTVHNLATHETFGFLKNVHRVAFKFFSWIPVSLSKEVQDSVRDMYCLESVIVNNGIKTNSEIINKSKEDIRKHYGLPLNSKIIITIGRLCTQKNQLLLIESFNKVCKNAENYTLLIVGEDNLNGSYKNKIDKIISELPDITRENLHLLGPRKDIPELLIASDVFVLSSDWEGVPLTLLEAMGYGTPVVCTSVGGIPDVIEHGFDGLLVSKGDSKSLGNAIIEVLSNNSFASSLAHNARKKFSQLYSIEMTAEKYLQLYNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VK8</accession>
    <name>Q39VK8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1482</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511586.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1482"/>
    <dbReference type="EnsemblBacteria" id="ABB31716">
        <property type="protein sequence ID" value="ABB31716"/>
        <property type="gene ID" value="Gmet_1482"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1482"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_775499_0_0_7"/>
    <dbReference type="OMA" id="CCYGKPL"/>
    <dbReference type="OrthoDB" id="1432078at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="347" mass="37106" checksum="37CF09318E5236DA" modified="2005-11-22" version="1">MTLFIVVTAVLSAIYLWWGIRFLPAERWQMAAAVPVSREADGSWQGVNITWYGILSANAYGAAALLFLALAASLGAPLVLTLSTLGVTLALCVPASRLVARIVEGKRHTFTVGGAVFVGTITAPFVVSLMNRLLAPADGRLPVMALLAAVASAYALGEGFGRLACISFGCCYGKPLSAAHPLIGRLLTRRAFIFRSETKKASYAGNLAGIPLVPIQGITAVLYTATALASAALFLSGQFALAFLIAMGITQLWRTVSEFLRDDYRGDNRISAYQIMGILAVAYGAATAFYFRGETPIIPDPGRIAAALWTPAAILPLQCIWLAILFYTGRSTVTGSRIFFHVHRERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VN3</accession>
    <name>Q39VN3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1457</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511613.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1457"/>
    <dbReference type="EnsemblBacteria" id="ABB31691">
        <property type="protein sequence ID" value="ABB31691"/>
        <property type="gene ID" value="Gmet_1457"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1457"/>
    <dbReference type="eggNOG" id="COG2831">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037019_0_0_7"/>
    <dbReference type="OMA" id="TYFTAPQ"/>
    <dbReference type="OrthoDB" id="956274at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005565">
        <property type="entry name" value="Hemolysn_activator_HlyB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013686">
        <property type="entry name" value="Polypept-transport_assoc_ShlB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08479">
        <property type="entry name" value="POTRA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03865">
        <property type="entry name" value="ShlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POTRA_2" evidence="3">
        <location>
            <begin position="70"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="ShlB" evidence="2">
        <location>
            <begin position="361"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="555" mass="61118" checksum="136653325CFCAD39" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VU3</accession>
    <name>Q39VU3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sigma-54-dependent transcriptional response regulator PilR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">pilR</name>
        <name evidence="8" type="ordered locus">Gmet_1397</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513111.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1397"/>
    <dbReference type="EnsemblBacteria" id="ABB31631">
        <property type="protein sequence ID" value="ABB31631"/>
        <property type="gene ID" value="Gmet_1397"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1397"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="AYDYICK"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="143"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="5">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="458" mass="51272" checksum="2816CCB17D715E66" modified="2005-11-22" version="1">MEIRILVVDDELSMREFLAILLKREGYAVDQADCAEKALEFLDSITYDLVISDVKMPGLDGIALLGRIKENSPDTAVLMMTAFSTAEQAVEAMKLGAYDYIAKPFKVEEVKVLVRNALEKRDLKRENQRLRQEVQERYGFSGLIGKSKKMRELYSLIERVAPSIANVLILGESGTGKELVARAIHYNSPRKDKAFVAVNCGAIPETLMESELFGHKKGSFTGAINDRAGLFEQAGGGTLFLDEIGEVPLQLQAKLLRVLQEKEFRRVGGVADQKADVRIVAASNRNLEEQVREGSFREDLFYRLNVVQLQMPPLRERTEDIPLLVEHFYRKYVQSNRNGEIITPGALKILMSYPFPGNVRELENLVERCMVLGGGTISEESLPPQVRGSQKSATAPVGDFEIPSEGMDLEGYLDGIEKRILLQALERCGGVKKKAAELLGLTFRSFRYRLAKFGMDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VV0</accession>
    <name>Q39VV0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513118.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1390"/>
    <dbReference type="EnsemblBacteria" id="ABB31624">
        <property type="protein sequence ID" value="ABB31624"/>
        <property type="gene ID" value="Gmet_1390"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1390"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093791_0_0_7"/>
    <dbReference type="OMA" id="WVPAPRY"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="252" mass="28280" checksum="39AF9193B7558D33" modified="2005-11-22" version="1">MEHRLAWYPTPSYLVKRKAIVEFLEKVPVRRVLEVGCGAGDLLRFLAGRGYAGVGIDLSAEAVAAARAIADLSRFRVEQAEVDDVSGIFEVVIASEVLEHCLDDVAFLRKLRRKTAEGGRLILTVPARMAKWGANDELCGHLRRYEREELRARLVEAGFEPLTVVSYGVPIYNLMKPFYDRAVVGKVTEVELLERRTEKSGGMRLLPRLGGLFALLFNDVTMYPFYLIQRLFYRTDLGNGYVAVALNPRGEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VV6</accession>
    <name>Q39VV6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ccdA-2</name>
        <name evidence="3" type="ordered locus">Gmet_1384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513124.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1384"/>
    <dbReference type="EnsemblBacteria" id="ABB31618">
        <property type="protein sequence ID" value="ABB31618"/>
        <property type="gene ID" value="Gmet_1384"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1384"/>
    <dbReference type="eggNOG" id="COG0785">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053225_2_0_7"/>
    <dbReference type="OMA" id="PMVPFYL"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003834">
        <property type="entry name" value="Cyt_c_assmbl_TM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02683">
        <property type="entry name" value="DsbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="DsbD" evidence="2">
        <location>
            <begin position="12"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="249" mass="26521" checksum="2C2DA0954BE1E915" modified="2005-11-22" version="1">MDFGSDITVWIAFSAGFLSFFSPCVLPLIPSYMTYITGLSFGQLQEAHPGAKVRLVVLAHSVVFVLGFSVVFVAMGALAGAASSTFQTVMKDGLVWLQRAGGLLIFMFGVHMSGLFHFGLLLGDKRVQIQNKPGGLAGTFLVGIAFAAGWTPCIGPILGAILAMAAGTSGSTATSMLLLGSYAAGLGIPFVISGLLFHGFLDIFKRFKSHIRKMEFFTGLLLMSVGILLFFGLFNNLTTLLYQWLPMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VV7</accession>
    <name>Q39VV7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TlpA family-related protein disulfide reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1383</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7" key="3">
        <citation type="submission" date="2009-05" db="PDB data bank">
            <title>The crystal structure of thioredoxin protein from Geobacter metallireducens.</title>
            <authorList>
                <person name="Zhang Z."/>
                <person name="Burley S.K."/>
                <person name="Swaminathan S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.77 ANGSTROMS) OF 22-168</scope>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513125.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="3HDC">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.77 A"/>
        <property type="chains" value="A=22-168"/>
    </dbReference>
    <dbReference type="PDBsum" id="3HDC"/>
    <dbReference type="SMR" id="Q39VV7"/>
    <dbReference type="STRING" id="269799.Gmet_1383"/>
    <dbReference type="DNASU" id="3740647"/>
    <dbReference type="EnsemblBacteria" id="ABB31617">
        <property type="protein sequence ID" value="ABB31617"/>
        <property type="gene ID" value="Gmet_1383"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1383"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_2_7"/>
    <dbReference type="OMA" id="LVYQIMS"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="EvolutionaryTrace" id="Q39VV7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223440" evidence="3">
        <location>
            <begin position="22"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="3HDC"/>
        </source>
    </evidence>
    <sequence length="168" mass="18828" checksum="BB0AE9BDFD3FB0DF" modified="2005-11-22" version="1">MNQLLRYICACLFTLTVLAVAAPGKAESDAPLVRTGALAPNFKLPTLSGENKSLAQYRGKIVLVNFWASWCPYCRDEMPSMDRLVKSFPKGDLVVLAVNVEKRFPEKYRRAPVSFNFLSDATGQVQQRYGANRLPDTFIVDRKGIIRQRVTGGIEWDAPKVVSYLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VX7</accession>
    <name>Q39VX7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2-oxoglutarate:ferredoxin oxidoreductase, thiamin diphosphate-binding subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">korB</name>
        <name evidence="2" type="ordered locus">Gmet_1363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513145.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1363"/>
    <dbReference type="EnsemblBacteria" id="ABB31597">
        <property type="protein sequence ID" value="ABB31597"/>
        <property type="gene ID" value="Gmet_1363"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1363"/>
    <dbReference type="eggNOG" id="COG1013">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048564_2_0_7"/>
    <dbReference type="OMA" id="FNNNIYG"/>
    <dbReference type="OrthoDB" id="981516at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TPP_enzyme_C" evidence="1">
        <location>
            <begin position="51"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="272" mass="29447" checksum="8DBBD35406E85768" modified="2005-11-22" version="1">MAFDYDKYIRPGKLPHIWCPGCGHGIVMKGLIRAMDSLNLKKEETCIVSGIGCASRLPGYIDCCTLHTAHGRAAAFATGVKMAKPEMNVILCGGDGDGTAIGGNHFIHACRRNINMTYIIMNNYIYGMTGGQFSPCTPTGAKASTTPYGNPDPGFDIAKLAIGAGATFVARGTAYHAAQIDKLIAEAIQHKGFSVVEILDDCPTTYGRRNKYRSVIDMMNRLKEVAVPVKAAEKMTAEQLEGKILTGVLHKIEKPEYTEEYAKVIQRAQAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W58</accession>
    <name>Q39W58_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Lipopolysaccharide ABC transporter, periplasmic protein LptC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">lptC</name>
        <name evidence="6" type="ordered locus">Gmet_1280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512086.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1280"/>
    <dbReference type="EnsemblBacteria" id="ABB31516">
        <property type="protein sequence ID" value="ABB31516"/>
        <property type="gene ID" value="Gmet_1280"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1280"/>
    <dbReference type="eggNOG" id="COG3117">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_120412_0_0_7"/>
    <dbReference type="OMA" id="HYTETKQ"/>
    <dbReference type="OrthoDB" id="1635370at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015221">
        <property type="term" value="F:lipopolysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010664">
        <property type="entry name" value="LipoPS_assembly_LptC-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026265">
        <property type="entry name" value="LptC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06835">
        <property type="entry name" value="LptC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04409">
        <property type="entry name" value="LptC_YrbK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="191" mass="20721" checksum="59CA30BB3450B24E" modified="2005-11-22" version="1">MVKPNKIRHILASVIVLATLYIAVSLALKLGAGGKKDEGLPALPRNVEISLSKIHYTETKDGVRQWDLYAGKGEYDKARDVTRLTDVRLVLHERGKSGEITLVSDQADYFNAAKNVALTGNVVAKSESGMEFTTGRASYQSNRSLVVTDDRVRFTDGGMSVSGVGMELSVKTRQVRILRDVTATVAPGKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WB3</accession>
    <name>Q39WB3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA repair exonuclease SbcCD, C subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">sbcC</name>
        <name evidence="4" type="ordered locus">Gmet_1224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512145.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1224"/>
    <dbReference type="EnsemblBacteria" id="ABB31461">
        <property type="protein sequence ID" value="ABB31461"/>
        <property type="gene ID" value="Gmet_1224"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1224"/>
    <dbReference type="eggNOG" id="COG0419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_387738_0_0_7"/>
    <dbReference type="OMA" id="LFTCHEE"/>
    <dbReference type="OrthoDB" id="370464at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="AAA_23" evidence="3">
        <location>
            <begin position="7"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="467"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="723" mass="80570" checksum="F4F2730092CCB12A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WC1</accession>
    <name>ACCA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha</fullName>
            <shortName evidence="1">ACCase subunit alpha</shortName>
            <shortName evidence="1">Acetyl-CoA carboxylase carboxyltransferase subunit alpha</shortName>
            <ecNumber evidence="1">2.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">accA</name>
        <name type="ordered locus">Gmet_1216</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + N(6)-carboxybiotinyl-L-lysyl-[protein] = malonyl-CoA + N(6)-biotinyl-L-lysyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:54728"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="EC" id="2.1.3.15"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccA family.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.15" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512154.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39WC1"/>
    <dbReference type="SMR" id="Q39WC1"/>
    <dbReference type="STRING" id="269799.Gmet_1216"/>
    <dbReference type="EnsemblBacteria" id="ABB31453">
        <property type="protein sequence ID" value="ABB31453"/>
        <property type="gene ID" value="Gmet_1216"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1216"/>
    <dbReference type="eggNOG" id="COG0825">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015486_0_2_7"/>
    <dbReference type="OMA" id="TPWQRVQ"/>
    <dbReference type="OrthoDB" id="886663at2"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009317">
        <property type="term" value="C:acetyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016743">
        <property type="term" value="F:carboxyl- or carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00823">
        <property type="entry name" value="AcetylCoA_CT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001095">
        <property type="entry name" value="Acetyl_CoA_COase_a_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42853">
        <property type="entry name" value="PTHR42853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03255">
        <property type="entry name" value="ACCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01069">
        <property type="entry name" value="ACCCTRFRASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00513">
        <property type="entry name" value="accA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000062625" description="Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="39"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01137"/>
        </source>
    </evidence>
    <sequence length="318" mass="35559" checksum="BC254D9445483D97" modified="2005-11-22" version="1">MASQYQLEFEKPVFELEQKIQELADIAGDNVELKTEVVKLEKKVDKMREVIFANLSRWQMVQVARHIDRPFTLDYLTHIFTDFVELHGDRLFGDDHAIVGGMAKLDGEPVMVIGHQKGRDTKEKVYRNFGMPNPEGYRKALRLMEMAERFRMPIITFVDTPGAYPGIGAEERGQAEAIARNLREMAALTVPIIVVITGEGGSGGALAIAVGDRVLMLEYSIYAVISPEGCAAILWSDGTKGAQAAEALKLTAPDLKELDVIDEIVKEPLGGAHRDHETMAKNLHEALARHLKELKALSVEQLVEGRYQKFRKMSRFAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X21</accession>
    <name>Q39X21_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Sigma-54-dependent transcriptional response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0961</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514355.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0961"/>
    <dbReference type="EnsemblBacteria" id="ABB31203">
        <property type="protein sequence ID" value="ABB31203"/>
        <property type="gene ID" value="Gmet_0961"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0961"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_0_6_7"/>
    <dbReference type="OMA" id="APMISVN"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Response regulatory" evidence="8">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="7">
        <location>
            <begin position="143"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="454" mass="50479" checksum="AB7BBD39A7FBA846" modified="2005-11-22" version="1">MKQRVLVIDDEENLRHMLGAMLRKNGYHADEAADGEQALAMAGEHPYDFIICDIRMPVLDGLGFLRRAQEAGIGGTIIMMSAYGTIDTALQCMKEGAYDYVSKPFKNDEILLVLKKAEERERLKTENCRLRAEVAREYSFGAIVSRNPRMREIFELIRKVCDVKTSVLVLGESGTGKELVARAIHHNGSRRDAPFVAVNCGAIPEHLLESELFGHVRGAFTDAASDRTGLFEEAHGGTLFLDEIGEMPPSLQVKLLRVLQEGEVRRVGAERLSKVDVRVISATSRDLEREVAEGHFREDLFFRLNVVSITLPPLRERLEDVPLLAGHFLNKHGTSLGRPGARVSPEALRLLSAYAWPGNVRELENCIERALILGDGDVVGPGALPDGLRGGGAGWAMVGPDNDNLSIKKAEERLEREFIRRALEKTGGNRTHAARILEISHRALLYKLKEYDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X93</accession>
    <name>Q39X93_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513036.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0889"/>
    <dbReference type="CAZy" id="CBM50">
        <property type="family name" value="Carbohydrate-Binding Module Family 50"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31131">
        <property type="protein sequence ID" value="ABB31131"/>
        <property type="gene ID" value="Gmet_0889"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0889"/>
    <dbReference type="eggNOG" id="COG1652">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050533_1_0_7"/>
    <dbReference type="OMA" id="PELWGMN"/>
    <dbReference type="OrthoDB" id="1833920at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223409" evidence="1">
        <location>
            <begin position="25"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="2">
        <location>
            <begin position="30"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="333" mass="36711" checksum="7BE9196BF71ABA8E" modified="2005-11-22" version="1">MKRVFSIGCMLLAGALLTVGTVRAASEEPTIYVIQKGDTLWGLSDRFLKDPYYWPNLWARNPAIGNPHFIYPGQRVRVYPDRIEIEPRTVSPGTPAVQRPSEEPVAERSFLVSGSEGFLMEKGLNPAGRIITTSQNRQIVGEDDIVYTDIGSVHGAKEGDRFSIYKKLDAVSHPVSNVILGEKVIPLGTLQLTEVEEKVSKAIITKSYREIGPGSILLPYRDKRRQISLKAADHDLSGYIVETQSGNNAIGEGDIAFIDLGKKQGIEPGYFLYILRDVVPDQQYADISVEKLPPEVVGALVVVQSGENTSTGLVVKSIDTIYRGDRVEARTNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XE3</accession>
    <name>Q39XE3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512983.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0839"/>
    <dbReference type="EnsemblBacteria" id="ABB31081">
        <property type="protein sequence ID" value="ABB31081"/>
        <property type="gene ID" value="Gmet_0839"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0839"/>
    <dbReference type="eggNOG" id="ENOG5032WZF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1342206_0_0_7"/>
    <dbReference type="OMA" id="EATYAIM"/>
    <dbReference type="OrthoDB" id="1669945at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="205" mass="21029" checksum="50ECF87895372D32" modified="2005-11-22" version="1">MKIRLISLVTLAAFTLGGITGCVTIQKEHEGAAKGAGYGGAAGALAGALLAGEGSRTKGAVLGGLAGALIGGVIGNYTIDKKLTAEETAAKYNVQPSSGTMVRLENVTTTPITVNPGERVEVQTTYALLTPSTTEQVGLTESVEIYHGGELVGNPEAMVTHGGGTYTFTIPIVLPKDAKTGNYRVISTVKSATAKDSRETSFTVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XF4</accession>
    <name>Q39XF4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0828"/>
    <dbReference type="EnsemblBacteria" id="ABB31070">
        <property type="protein sequence ID" value="ABB31070"/>
        <property type="gene ID" value="Gmet_0828"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0828"/>
    <dbReference type="HOGENOM" id="CLU_1208365_0_0_7"/>
    <dbReference type="OMA" id="EANANIH"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223487" evidence="1">
        <location>
            <begin position="20"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="249" mass="26973" checksum="2A740A2C759D5D19" modified="2005-11-22" version="1">MQAKLKLTAGIFLCAMVLAGCGGGLNASNPDAPSSVNAHECTWVTTHPKKIIEMVTFRVISSATQATFNATYGEDELIQCRVCHGSSFLGAGGGAAGPACLDCHIADPVRYPAGCYSCHGGVIVDSRFPDQVSSGPYEKFYARYSTTPQFSQYSAARQAFIDRVKSGSIHNRLSPTLPRNHNALGYVFADANPQDTCVYCHNQEANANIHHSEAITNRFSCGFCHFRFIGGELQFVIIRDCKVCHVQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XI6</accession>
    <name>Q39XI6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCP-like extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513541.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0796"/>
    <dbReference type="EnsemblBacteria" id="ABB31038">
        <property type="protein sequence ID" value="ABB31038"/>
        <property type="gene ID" value="Gmet_0796"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0796"/>
    <dbReference type="eggNOG" id="COG2340">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085385_0_0_7"/>
    <dbReference type="OMA" id="YRTICVI"/>
    <dbReference type="OrthoDB" id="1705869at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="SSF55797"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223400" evidence="1">
        <location>
            <begin position="27"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="72"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="212" mass="23379" checksum="6BC6888C646FB6AC" modified="2005-11-22" version="1">MIFTTLRATLAMLAAMAIACALPVRASAGDNLARGVLAELNAARANPKAYAEHLRVYRSQFTGTYHIPPGSRIRYITREGTRAVDEAVRFLEAQRPLSPLTWSEGLSRVAAELNREQARTGALGHASGRMEMRARAERIGRWQSTIGENISYGPDDARRVVMQLIVDDGVPDRGHRKNIFAPDFRVAGIACGPHPVFETSCVIDFAGWFTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XS2</accession>
    <name>Q39XS2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">N-carbamylputrescine amidohydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">aguB</name>
        <name evidence="2" type="ordered locus">Gmet_0710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514615.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0710"/>
    <dbReference type="EnsemblBacteria" id="ABB30952">
        <property type="protein sequence ID" value="ABB30952"/>
        <property type="gene ID" value="Gmet_0710"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0710"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_4_0_7"/>
    <dbReference type="OMA" id="NAPYFCQ"/>
    <dbReference type="OrthoDB" id="1583074at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="294" mass="32743" checksum="DB332B1A06A9CAEE" modified="2005-11-22" version="1">MSKLTVGLVQQSCTSDKDLNLAKSIENIRKASALGAKLVVLQELHCGPYFCQNEDTGHFDLAEEIPGPTTELLGGVAREFGVVLVSSLFEKRASGIYHNTAVVFEKDGSIAGKYRKMHIPDDPGYYEKFYFTPGDLGFEPIRTSVGKLGVLVCWDQWYPEAARLMALAGADLLIYPTAIGWDPRDEDEEKVRQKEAWITIQRGHAVANGIPVVSVNRVGLEPDPSGVLPGSLFWGSSFVAGPQGEILTQASNDREELLSVELDLDRSEAVRRIWPFLRDRRIDAYQDLLKRYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XU1</accession>
    <name>Q39XU1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cupin superfamily barrel domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0691</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30933.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514082.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0691"/>
    <dbReference type="EnsemblBacteria" id="ABB30933">
        <property type="protein sequence ID" value="ABB30933"/>
        <property type="gene ID" value="Gmet_0691"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0691"/>
    <dbReference type="eggNOG" id="COG1917">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_141446_2_0_7"/>
    <dbReference type="OMA" id="MIIMPAN"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin_2" evidence="1">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30933.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="110" mass="11975" checksum="B6FD6A377B0CD55C" modified="2012-10-31" version="2">MSGTTESLVGRAIDLKELIAYQEGSVVSKTLNDKKVGTITLFAFDKGQGLSEHTAPYDAFVEIVDGEADITIVGTDHRVKEGQFIIMPANQPHALRAVTPFKMLLVMIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XV3</accession>
    <name>Q39XV3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514070.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0679"/>
    <dbReference type="EnsemblBacteria" id="ABB30921">
        <property type="protein sequence ID" value="ABB30921"/>
        <property type="gene ID" value="Gmet_0679"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0679"/>
    <dbReference type="eggNOG" id="COG4885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032391_0_0_7"/>
    <dbReference type="OMA" id="CQDCHMT"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023155">
        <property type="entry name" value="Cyt_c-552/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13435">
        <property type="entry name" value="Cytochrome_C554"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223507" evidence="1">
        <location>
            <begin position="27"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C554" evidence="2">
        <location>
            <begin position="59"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="490" mass="53847" checksum="BEF3BEA2162AFA63" modified="2005-11-22" version="1">MKRTSRLAATLFVCFAIICAAVAAQATSPVFPVDREFYPYYPSLIKWNKSSVPFNAPEVCGGCHEKQYKEWNGSVHSLAFKDPVYQGELNKAVKAVGHDIARQCEGCHTPIGVVTGEVKAPGLAGLSAIALAGVSCDVCHSISGVTHQQTPARVAENGSFIMTPGVETTSGQALIKRGPIPNHKECGGGFHQCEESPLHLQANLCASCHQVYHYDDHFPIEATYNEWIAGPYAQKGIMCQDCHMVDVQTFKRTADQFVKPERKEYKHYFSGANYLLTYLASGAAKKAGDEELAKSMMNQYEMAVERLKSAADLELFPIYHNGKLDELKVRVKNIRAGHNLPTSLTNVRQMWLEITAKDENGKVVMTSGTLNPDGSLSEVARNFASDGMTKDFHFTVDPWSLVSFSKHDTIPPKGYRETYYGLHFPAGLKKVTIEAKLRFRQADQKVAEALLAAVPKDINLEQTYGLKAVPPLPVVDMAVKQVTVDTSSAS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y25</accession>
    <name>RL13_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplM</name>
        <name type="ordered locus">Gmet_0606</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514736.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y25"/>
    <dbReference type="SMR" id="Q39Y25"/>
    <dbReference type="STRING" id="269799.Gmet_0606"/>
    <dbReference type="PRIDE" id="Q39Y25"/>
    <dbReference type="EnsemblBacteria" id="ABB30849">
        <property type="protein sequence ID" value="ABB30849"/>
        <property type="gene ID" value="Gmet_0606"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0606"/>
    <dbReference type="eggNOG" id="COG0102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082184_2_2_7"/>
    <dbReference type="OMA" id="DFVVIIN"/>
    <dbReference type="OrthoDB" id="1822215at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_L13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005823">
        <property type="entry name" value="Ribosomal_L13_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_L13_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="PTHR11545"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002181">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="SSF52161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01066">
        <property type="entry name" value="rplM_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000261729" description="50S ribosomal protein L13">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01366"/>
        </source>
    </evidence>
    <sequence length="143" mass="15921" checksum="63F75515DBADE3BF" modified="2005-11-22" version="1">MKTTKVAKKEEVTRDWFLVDADNKVLGRMATEIANILRGKKKPIYTPSVDTGDFVVVVNAEKIQLTGNKLADKMYYSHSGFPGGIKSIAAGKLIEKKPEDLIRKAVKGMLPKNKLARHMLKKLKVYAGPAHPHEAQQPKTLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y52</accession>
    <name>Q39Y52_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ResC/HemX-like cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512277.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0579"/>
    <dbReference type="EnsemblBacteria" id="ABB30822">
        <property type="protein sequence ID" value="ABB30822"/>
        <property type="gene ID" value="Gmet_0579"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0579"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049710_2_2_7"/>
    <dbReference type="OMA" id="IWAKDLW"/>
    <dbReference type="OrthoDB" id="213184at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="82"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="269" mass="29708" checksum="E7295E5D10EBCF52" modified="2005-11-22" version="1">MDVIFFWIATTLYALSAVLYLIHFIFDKKWGEKGAAALAAGGIVPHVAAVAMRWVQAGHGPYITRYEVFSSDALIAVAVFLAAGLLYRKIRVAGAIVMSGAFLMMGYGALSVDTKAAAPITFKSWWLVIHILFGKVITGAMLIAGALAVFYLLKSKRPERWPRLPDVASLDDLSYRFLSLGFCALGLMIVAGSIWANSAWGRYWGWDPIETWSLISWITVGAILHLRRLHGWRGRRMAWLTIAALLLAIFTAFLITIVSPGIHSSYMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y96</accession>
    <name>Q39Y96_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0535</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30778.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512231.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0535"/>
    <dbReference type="EnsemblBacteria" id="ABB30778">
        <property type="protein sequence ID" value="ABB30778"/>
        <property type="gene ID" value="Gmet_0535"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0535"/>
    <dbReference type="eggNOG" id="ENOG5033FNH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2219368_0_0_7"/>
    <dbReference type="OMA" id="DPFLWHE"/>
    <dbReference type="OrthoDB" id="1842825at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30778.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="98" mass="11094" checksum="D1CBA21A1502644A" modified="2012-10-31" version="2">MPVPQQLGRGDRMGRGPYEKSGIIEDTGLPPGKAVHERFDIFFPVDEVEENGKWVTKPTASELDLEVKLWYLPFGTMNADPFLWHEFTKKVSISTTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YA5</accession>
    <name>Q39YA5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0526</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512222.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0526"/>
    <dbReference type="EnsemblBacteria" id="ABB30769">
        <property type="protein sequence ID" value="ABB30769"/>
        <property type="gene ID" value="Gmet_0526"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0526"/>
    <dbReference type="eggNOG" id="COG1368">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014653_1_0_7"/>
    <dbReference type="OMA" id="VSNHRPF"/>
    <dbReference type="OrthoDB" id="1067869at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012160">
        <property type="entry name" value="LtaS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005091">
        <property type="entry name" value="Mmb_sulf_HI1246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="SSF53649"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase" evidence="7">
        <location>
            <begin position="274"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005091-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="633" mass="70785" checksum="A599C68A659E1513" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YC2</accession>
    <name>Q39YC2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidoglycan-binding inner membrane lipoprotein YiaD, OmpA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0509</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512205.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0509"/>
    <dbReference type="EnsemblBacteria" id="ABB30752">
        <property type="protein sequence ID" value="ABB30752"/>
        <property type="gene ID" value="Gmet_0509"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0509"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_6_4_7"/>
    <dbReference type="OMA" id="IGNYMDK"/>
    <dbReference type="OrthoDB" id="2018797at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039567">
        <property type="entry name" value="Gly-zipper"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13488">
        <property type="entry name" value="Gly-zipper_Omp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223442" evidence="4">
        <location>
            <begin position="21"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="5">
        <location>
            <begin position="100"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="218" mass="22220" checksum="02B8A41B4E48AA2E" modified="2005-11-22" version="1">MKRTALCALTIAMAALTGCAQPMTRTQTGAALGTGVGAAVGAGLGQAIGRNTESTLIGAAAGALAGGLTGGAIGNYMDKQEQAMRQAVANVEGASIQRDQNVLAVTFKSDILFPINSAVLQPGANDEITRVAQVLTQYPATTITIAGHTDSTGSDALNQTLSERRATAVKNALAARGVAPARMNAIGFGKSKPIADNSTEAGRSMNRRVEITIVPQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YH7</accession>
    <name>Q39YH7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase, SpsF domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513822.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0454"/>
    <dbReference type="EnsemblBacteria" id="ABB30697">
        <property type="protein sequence ID" value="ABB30697"/>
        <property type="gene ID" value="Gmet_0454"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0454"/>
    <dbReference type="eggNOG" id="COG1861">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3980">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_459879_0_0_7"/>
    <dbReference type="OMA" id="KASIYCH"/>
    <dbReference type="OrthoDB" id="881501at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003329">
        <property type="entry name" value="Cytidylyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007235">
        <property type="entry name" value="Glyco_trans_28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02348">
        <property type="entry name" value="CTP_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04101">
        <property type="entry name" value="Glyco_tran_28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_tran_28_C" evidence="1">
        <location>
            <begin position="418"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="593" mass="66039" checksum="D8DB8DE484225437" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YH8</accession>
    <name>Q39YH8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0453</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513821.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0453"/>
    <dbReference type="EnsemblBacteria" id="ABB30696">
        <property type="protein sequence ID" value="ABB30696"/>
        <property type="gene ID" value="Gmet_0453"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0453"/>
    <dbReference type="eggNOG" id="COG2227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_080372_0_0_7"/>
    <dbReference type="OMA" id="YRAFESS"/>
    <dbReference type="OrthoDB" id="1730305at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="305" mass="35131" checksum="8E9A3DBBAD746A61" modified="2005-11-22" version="1">MAEKKTWCDHEGEVCDSVKGFDVIDCSKCGFKHIVPIPSAEELEEVYRHEYYTSEKPLYLERYREDLDWWNLVYGDRYDTFEELLPQKRRRILDIGSGPGFFLKHGKDRGWETVGIEPSARAAAHSREMGLDIIEEFFSTDTAIQLGLFDVIHMSAVLEHIPDPEHFLGIVRKNLTPEGILCVVVPNDYNPFQLALRTACNFQPWWVAPPHHINFFDFESLEHLLTRSGFEVTCKESTFPIDLFLLMGDNYIGNDTRGRACHAKRMQFETNLAAAGLTSVKRSLYQSLANLNIGREVCLYSRRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="115" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YM3</accession>
    <name>Q39YM3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase</fullName>
            <ecNumber evidence="6 7">6.3.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">D-alanyl-D-alanine-adding enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 11" type="primary">murF</name>
        <name evidence="11" type="ordered locus">Gmet_0408</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine</text>
            <dbReference type="Rhea" id="RHEA:28374"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57822"/>
            <dbReference type="ChEBI" id="CHEBI:61386"/>
            <dbReference type="ChEBI" id="CHEBI:83905"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 7">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MurCDEF family. MurF subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.10" evidence="6 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512380.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0408"/>
    <dbReference type="EnsemblBacteria" id="ABB30651">
        <property type="protein sequence ID" value="ABB30651"/>
        <property type="gene ID" value="Gmet_0408"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0408"/>
    <dbReference type="eggNOG" id="COG0770">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031507_1_1_7"/>
    <dbReference type="OMA" id="VEMGANH"/>
    <dbReference type="OrthoDB" id="1861122at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047480">
        <property type="term" value="F:UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008766">
        <property type="term" value="F:UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02019">
        <property type="entry name" value="MurF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000713">
        <property type="entry name" value="Mur_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035911">
        <property type="entry name" value="MurE/MurF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005863">
        <property type="entry name" value="UDP-N-AcMur_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01225">
        <property type="entry name" value="Mur_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63418">
        <property type="entry name" value="SSF63418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01143">
        <property type="entry name" value="murF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 6 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 6 7" id="KW-0133">Cell shape</keyword>
    <keyword evidence="5 6 7" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 6 7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur_ligase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_M" evidence="10">
        <location>
            <begin position="112"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Mur_ligase_C" evidence="9">
        <location>
            <begin position="320"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="114"/>
            <end position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="470" mass="49372" checksum="DEFF105817F8B5D1" modified="2005-11-22" version="1">MLFSLADIREATGGTLGGEGKTAGVEGVSTDSRTVQPGELFVPLRGERFDGHDYLGAACDRGVQVVLAEHQWLEKNELPPGVSAVAVDDTLEALGDLACFHRQRFAIPVVAVTGSNGKTTTKEMLAAILGQTGPGLKTEGNLNNLIGLPQMLLRLDNSHRWAVLEMGMSAFGEIDRLAEIARPDVGIITNAYPAHLETLGSVEGVARAKGELFLRLPAEGCAVFNADDPLIARCPSPDGVRRVSFGLHNADVTAEAVENLGRNGQRFILRLSTESVPVTLRAFGRHNIANALAAAAAAHVLGVPTETIARGLGEFSPYARRFNLEEVGDVILIDDSYNANPASMAAALTTLREIRAGRRAVAVLGDMLELGEGAEEAHRQLGLLAATCVDRLYVMGGMAGIVAAGALEGGLADDAVTVATSHDAIVADLRRTTAAGDFILVKGSRGLAMDRVAEKMREVFVASLGKGASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YS5</accession>
    <name>Q39YS5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365659.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0356"/>
    <dbReference type="EnsemblBacteria" id="ABB30599">
        <property type="protein sequence ID" value="ABB30599"/>
        <property type="gene ID" value="Gmet_0356"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0356"/>
    <dbReference type="eggNOG" id="COG2911">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2982">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_272122_0_0_7"/>
    <dbReference type="OMA" id="DLWAREG"/>
    <dbReference type="OrthoDB" id="435238at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1182" mass="124575" checksum="4CF2CFA4FBC392CC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YT5</accession>
    <name>Q39YT5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-D-arabino-heptulosonate 7-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroG-2</name>
        <name evidence="3" type="ordered locus">Gmet_0346</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512317.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0346"/>
    <dbReference type="EnsemblBacteria" id="ABB30589">
        <property type="protein sequence ID" value="ABB30589"/>
        <property type="gene ID" value="Gmet_0346"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0346"/>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_0_0_7"/>
    <dbReference type="OMA" id="SMTIQEF"/>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="89"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="339" mass="36575" checksum="3700363CE7C76330" modified="2005-11-22" version="1">MIIVMKAGAAKKDRDEVIKRIKELGYKPHVIHGTTRDVIGAVGDERGKLVLQSIESMHGVESVVPILKPYKLASKEVKVEPSIIRISDAVSIGGKEIIVMAGPCSVEGEEQIIETAKAVKAAGAQVLRGGAFKPRTSPYSFQGLEEEGLKLLAKAREITGLPIVTEVVNPETADLVAEYSDILQIGARNAQNFALLKKVGQLRRPVLLKRGMSMTIQEFLMSAEYVLSEGNQSVILCERGIRTFETATRNTLDLSAIPVLKGMTHLPVIADPSHGTGNYHYVAPMALAAVAAGADGLMIEVHPDPERASSDGPQSLKPKKFDALMTKLRLVAESVDRIV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-11-13" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z17</accession>
    <name>Y262_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0502 protein Gmet_0262</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_0262</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0502 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513579.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z17"/>
    <dbReference type="SMR" id="Q39Z17"/>
    <dbReference type="STRING" id="269799.Gmet_0262"/>
    <dbReference type="EnsemblBacteria" id="ABB30507">
        <property type="protein sequence ID" value="ABB30507"/>
        <property type="gene ID" value="Gmet_0262"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0262"/>
    <dbReference type="eggNOG" id="COG3132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057831_1_0_7"/>
    <dbReference type="OMA" id="CNQKSSR"/>
    <dbReference type="OrthoDB" id="1721848at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01584">
        <property type="entry name" value="UPF0502"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007432">
        <property type="entry name" value="DUF480"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38768">
        <property type="entry name" value="PTHR38768"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04337">
        <property type="entry name" value="DUF480"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000309390" description="UPF0502 protein Gmet_0262">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01584"/>
        </source>
    </evidence>
    <sequence length="219" mass="24779" checksum="99BDDA501E2125B5" modified="2005-11-22" version="1">METVLNSCEIRVLGCLVEKELATPEYYPLTLNALTAACNQKSNRDPVMALEDADVVRALDSLRMKGFARQSAEGVRAMKYCHCLAEKFLLEPPDLAVLAELLVRGPQTVGELRTRAERMRPFADLAAVEEVLRMLMEREEPLVTRLPRQPGRKEQRYAHLLAGAPEAEGEESMAPPEGARLQVRAENERVARLEEEVTALRAEVAELRRMMEEFRSQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z50</accession>
    <name>Q39Z50_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transposase of ISGme6, ISL3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0081</name>
        <name evidence="3" type="ordered locus">Gmet_0229</name>
        <name evidence="4" type="ordered locus">Gmet_1002</name>
        <name evidence="5" type="ordered locus">Gmet_1333</name>
        <name evidence="6" type="ordered locus">Gmet_1398</name>
        <name evidence="7" type="ordered locus">Gmet_1978</name>
        <name evidence="8" type="ordered locus">Gmet_2160</name>
        <name evidence="9" type="ordered locus">Gmet_2484</name>
        <name evidence="10" type="ordered locus">Gmet_3003</name>
    </gene>
    <organism evidence="3 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514804.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30330">
        <property type="protein sequence ID" value="ABB30330"/>
        <property type="gene ID" value="Gmet_0081"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30474">
        <property type="protein sequence ID" value="ABB30474"/>
        <property type="gene ID" value="Gmet_0229"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31244">
        <property type="protein sequence ID" value="ABB31244"/>
        <property type="gene ID" value="Gmet_1002"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31568">
        <property type="protein sequence ID" value="ABB31568"/>
        <property type="gene ID" value="Gmet_1333"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31632">
        <property type="protein sequence ID" value="ABB31632"/>
        <property type="gene ID" value="Gmet_1398"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32207">
        <property type="protein sequence ID" value="ABB32207"/>
        <property type="gene ID" value="Gmet_1978"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32389">
        <property type="protein sequence ID" value="ABB32389"/>
        <property type="gene ID" value="Gmet_2160"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32709">
        <property type="protein sequence ID" value="ABB32709"/>
        <property type="gene ID" value="Gmet_2484"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33218">
        <property type="protein sequence ID" value="ABB33218"/>
        <property type="gene ID" value="Gmet_3003"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0081"/>
    <dbReference type="KEGG" id="gme:Gmet_0229"/>
    <dbReference type="KEGG" id="gme:Gmet_1002"/>
    <dbReference type="KEGG" id="gme:Gmet_1333"/>
    <dbReference type="KEGG" id="gme:Gmet_1398"/>
    <dbReference type="KEGG" id="gme:Gmet_1978"/>
    <dbReference type="KEGG" id="gme:Gmet_2160"/>
    <dbReference type="KEGG" id="gme:Gmet_2484"/>
    <dbReference type="KEGG" id="gme:Gmet_3003"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041900_0_2_7"/>
    <dbReference type="OMA" id="EAVACDM"/>
    <dbReference type="OrthoDB" id="1128314at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="158"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="417" mass="48962" checksum="298378A8D97B6962" modified="2005-11-22" version="1">MLIKTVLNKFERFKSFIYGDCRLAKVGGSEALVIDIKARRNSKPECPECGKRGKTYDTQPARLFEYVPIWAFKVFFRYAPRRVLCPIHGVKVESLPWGYGKEQMTISYQVYLARWARRLSWKEVAEIFKTSWDSIFRAVQYAVDYGLANRNLDGVTEIGVDEIAVFKGHQYLTMVYQLNAGVRRLLWCGPQRRIRTLLRFFREFGKERSAKLKYVCSDMWAPYLKVIAKRAPNAVNILDRFHIMRKFNEAIDEVRRTEAKEFKAAKQENVLEKGRWLLLKRPENLSEKQTSRLGDLLKLNLSSIKAYLLREDFQQFWDYQRSDFAGKFLDDWVIRTMQTDLEPMKKVARMLRNHKPMILNWFKAKGRLSSGAVEGLNLKAKLTIRKAYGFRTIKCLQVALYHTLGDLPEPLCHHRFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z87</accession>
    <name>Q39Z87_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PilZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512780.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0191"/>
    <dbReference type="EnsemblBacteria" id="ABB30437">
        <property type="protein sequence ID" value="ABB30437"/>
        <property type="gene ID" value="Gmet_0191"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0191"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_102163_0_0_7"/>
    <dbReference type="OMA" id="YNDDGCR"/>
    <dbReference type="OrthoDB" id="1340682at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="117"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="232" mass="25649" checksum="9264F29C9888718F" modified="2005-11-22" version="1">MDDYYQLVPDADAREDNRQILETLAAIRKGTVSNDLRLLNYYQSIPVNFGATVESIDGDTVELAVHQQQAVVMHLEKQTFLKSSHFPKDVLAAVSYVNIDKCVAMVTKFAYAVVRAERRQFVRVEVKDPIEATFSASGVKVTGTLNDISIGGIAIAVSVPNPPENALEGSVRVGLPGGPFEIPAKLLRVIPANEKHLAICEIRPDARAEKGISQYIFQRQVEIIRELKDSIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z91</accession>
    <name>Q39Z91_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Membrane protein UPF0324</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0187</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0324 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512776.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30433">
        <property type="protein sequence ID" value="ABB30433"/>
        <property type="gene ID" value="Gmet_0187"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0187"/>
    <dbReference type="eggNOG" id="COG2855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033541_2_0_7"/>
    <dbReference type="OMA" id="IIVKMIR"/>
    <dbReference type="OrthoDB" id="1856009at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018383">
        <property type="entry name" value="UPF0324_pro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30106">
        <property type="entry name" value="PTHR30106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03601">
        <property type="entry name" value="Cons_hypoth698"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="310" mass="32400" checksum="9D903EE48ADA2721" modified="2005-11-22" version="1">MNATRLHKVLFVILLALCATPWVGTALALVMGISFSLLLGNQWPRKTAHYSTKLLQVSVVGLGFGLGLGEVLQTGKNSIWYSAIGIAGTLLVGSVLGTLFRTDRNTSALISFGTAICGGSAIAAMAPVLKAKDDETAVALATVFTLNSVALLLFPLIGRWLQLDQTMFGVWSGLAIHDTSSVVGATSAYGPLALTIGTTVKLTRAIWIAPAVMAVSLIKGGKQRARILLFIVGFIGAATIRTVLPMFGQYWGVLAAVAKQCLVMTLFMVGAGLSREVVGAVGIRPLLHAVTLWGVVSTLTLVALKVVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZE8</accession>
    <name>Q39ZE8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514132.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0127"/>
    <dbReference type="DNASU" id="3738034"/>
    <dbReference type="EnsemblBacteria" id="ABB30376">
        <property type="protein sequence ID" value="ABB30376"/>
        <property type="gene ID" value="Gmet_0127"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0127"/>
    <dbReference type="eggNOG" id="COG4887">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091350_0_0_7"/>
    <dbReference type="OMA" id="GLCIGHD"/>
    <dbReference type="OrthoDB" id="1169851at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014997">
        <property type="entry name" value="DUF1847"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08901">
        <property type="entry name" value="DUF1847"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="243" mass="26321" checksum="5DD60C9FAA5D8E20" modified="2005-11-22" version="1">MADNETIPSCANCSAVWQKSGTTNCWSSPDNRPGQPANCPSKTSPDIIDESFAEYRGDGDDARLARVAARVEGLCYQKMQGSDAVVARWTRVEDTVALAKLMGWTKVGIATCIGLLEETKQLVTILEAQGLEPASVCCKSGSIDKLELGLEESDKVRPGTFEPACNPIAQAEILNRCGTQMNIIVGLCVGHDMLFTKHSKAPVTTLVCKDRVTGHNPAAVLYGQNFYYKRLKVQPVAVPTEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZF9</accession>
    <name>Q39ZF9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrogenase expression/formation protein HypE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hypE</name>
        <name evidence="4" type="ordered locus">Gmet_0116</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HypE family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30365.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514121.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0116"/>
    <dbReference type="EnsemblBacteria" id="ABB30365">
        <property type="protein sequence ID" value="ABB30365"/>
        <property type="gene ID" value="Gmet_0116"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0116"/>
    <dbReference type="eggNOG" id="COG0309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049733_0_0_7"/>
    <dbReference type="OMA" id="CGNGGKE"/>
    <dbReference type="OrthoDB" id="1016556at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd02197">
        <property type="entry name" value="HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011854">
        <property type="entry name" value="HypE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30303">
        <property type="entry name" value="PTHR30303"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005644">
        <property type="entry name" value="Hdrgns_mtr_HypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02124">
        <property type="entry name" value="hypE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRS" evidence="2">
        <location>
            <begin position="39"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="3">
        <location>
            <begin position="162"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30365.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="336" mass="34704" checksum="138B9B5EF15FF196" modified="2012-10-31" version="2">MNKDLILLGHGSGGKLSHQLLDDLIIPTLSGIPLAGQNDAAVVEHGGQRLAFTTDSYVVDPIFFPGGNIGSLAVNGTVNDLAMMGARPLFISAGLIVEEGFSRTELAGILASMRGAADAAGVRIVTGDTKVVPRGKADRIFINTSGIGAVEHDFAINGANARAGDVVIINGTIGDHGIAVMAEREGLDLRTAIRSDCAALNDLVAEIIAAGGDAVHVLRDPTRGGVATTLKEIALQSDKTITLREETLPLNGAVKGVCSILGLDPLYVANEGKLLAVVAPEAAERVLTRIKGHRLGRDAAIIGHVAEGGGRVQMETAVGGMRAVEMLAGEQLPRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZJ7</accession>
    <name>Q39ZJ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Phospholipase D superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514202.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0078"/>
    <dbReference type="EnsemblBacteria" id="ABB30327">
        <property type="protein sequence ID" value="ABB30327"/>
        <property type="gene ID" value="Gmet_0078"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0078"/>
    <dbReference type="eggNOG" id="COG1502">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026287_0_0_7"/>
    <dbReference type="OMA" id="LFNPFAN"/>
    <dbReference type="OrthoDB" id="1881748at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019637">
        <property type="term" value="P:organophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="2">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="502" mass="56159" checksum="920B24C96D27FE81" modified="2005-11-22" version="1">MIRPLLLITLSLLLILTAVPGARLSAAETTPVTLPLARSIQPLLSAHPGKTGLYVLEKGEESLLARAWLADHATKSIDVQYFIWSSDNIGILASEALLRAAERGIRVRVLVDDLLIDAPPESLLALARHPNIDIRIYNPKMTVGTSKVKRFANVVTGFRSVNQRMHDKTALFDGMVGITGGRNMADEYYDFDQEYTFRDRDMLMLGPTVAEAEASFARFWESPLAVPVEKLLKKPMKKMTPERTGQVYAGLHAYAGKPENFAPEVRQALQNLPRRFDGLLREMVWDEARFISDLPGKNSGREGLGGGGRSTAALVDAVSRAKRRVTIQSPYLVMPEGGVELFRKLIRRGVEVRIVTNSLAATDNLQAFSGYRKQRNRLLKAGITIREFRPDPAVRQELIDRYPKLKEKPPTFALHAKTMVIDGVTLFVGTFNLDPRSANLNTEVGVMVRNPALARQVEERIERDMRPENSWNPATDNPDRRASAAKRNRLRLWKSLPLTPIL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZL4</accession>
    <name>SELA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-seryl-tRNA(Sec) selenium transferase</fullName>
            <ecNumber evidence="1">2.9.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Selenocysteine synthase</fullName>
            <shortName evidence="1">Sec synthase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Selenocysteinyl-tRNA(Sec) synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">selA</name>
        <name type="ordered locus">Gmet_0061</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H(+) + L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22728"/>
            <dbReference type="Rhea" id="RHEA-COMP:9742"/>
            <dbReference type="Rhea" id="RHEA-COMP:9743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16144"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:78533"/>
            <dbReference type="ChEBI" id="CHEBI:78573"/>
            <dbReference type="EC" id="2.9.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (bacterial route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SelA family.</text>
    </comment>
    <dbReference type="EC" id="2.9.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514185.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZL4"/>
    <dbReference type="SMR" id="Q39ZL4"/>
    <dbReference type="STRING" id="269799.Gmet_0061"/>
    <dbReference type="DNASU" id="3739677"/>
    <dbReference type="EnsemblBacteria" id="ABB30310">
        <property type="protein sequence ID" value="ABB30310"/>
        <property type="gene ID" value="Gmet_0061"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0061"/>
    <dbReference type="eggNOG" id="COG1921">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038142_1_0_7"/>
    <dbReference type="OMA" id="GATNRTH"/>
    <dbReference type="OrthoDB" id="1124266at2"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00896"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004125">
        <property type="term" value="F:L-seryl-tRNASec selenium transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001514">
        <property type="term" value="P:selenocysteine incorporation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097056">
        <property type="term" value="P:selenocysteinyl-tRNA(Sec) biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00423">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018319">
        <property type="entry name" value="SelA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004534">
        <property type="entry name" value="SelA_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025862">
        <property type="entry name" value="SelA_trans_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12390">
        <property type="entry name" value="Se-cys_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03841">
        <property type="entry name" value="SelA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00474">
        <property type="entry name" value="selA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0711">Selenium</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000050366" description="L-seryl-tRNA(Sec) selenium transferase">
        <location>
            <begin position="1"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00423"/>
        </source>
    </evidence>
    <sequence length="462" mass="49874" checksum="2700C05E0B2D71A3" modified="2005-11-22" version="1">MTLFARIPKVDKILEWDGTKVLLGIHPRPTVLNAVRSVLDSLRTAARSGFLKEEELLEGAVASRIEREVARSTAFSLRRVVNGTGVVIHTNLGRSPLSKRVKPLLDEIAFGYSNLEFDLEKGERGSRYSHVERLLCDLTGAEAALVVNNNAAAVLLALSALAAGKEVVVSRGELVEIGGSFRIPDVMGQGGAILREVGTTNRTHPRDYHQAVSEQTALLLKVHSSNFAVVGFTAEVSATELVAIGKEHSVPVMADIGSGCLLDLSPFGIRGEPTVQEFVKAGVDVITFSGDKLLGGPQAGIIVGRREFIAPLTQHPLLRALRIDKLTLAALEGTLRLYRDERLALAEIPTLRMLTASAAELATRARSFARRIRRASPPDIRLTLTSGISQVGGGAYPLLELPTTLMAMEADGISPQEMEIRLRGMEVPVTGRIHRGRFLLDVRTLQDDDIPFIAAALSSLAD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZL6</accession>
    <name>ISPF_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase</fullName>
            <shortName evidence="1">MECDP-synthase</shortName>
            <shortName evidence="1">MECPP-synthase</shortName>
            <shortName evidence="1">MECPS</shortName>
            <ecNumber evidence="1">4.6.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ispF</name>
        <name type="ordered locus">Gmet_0059</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP</text>
            <dbReference type="Rhea" id="RHEA:23864"/>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="4.6.1.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="1">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IspF family.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.12" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514183.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZL6"/>
    <dbReference type="SMR" id="Q39ZL6"/>
    <dbReference type="STRING" id="269799.Gmet_0059"/>
    <dbReference type="EnsemblBacteria" id="ABB30308">
        <property type="protein sequence ID" value="ABB30308"/>
        <property type="gene ID" value="Gmet_0059"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0059"/>
    <dbReference type="eggNOG" id="COG0245">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_084630_2_0_7"/>
    <dbReference type="OMA" id="QHFGTGR"/>
    <dbReference type="OrthoDB" id="1716560at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00095"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008685">
        <property type="term" value="F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00554">
        <property type="entry name" value="MECDP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00107">
        <property type="entry name" value="IspF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003526">
        <property type="entry name" value="MECDP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020555">
        <property type="entry name" value="MECDP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036571">
        <property type="entry name" value="MECDP_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43181">
        <property type="entry name" value="PTHR43181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02542">
        <property type="entry name" value="YgbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69765">
        <property type="entry name" value="SSF69765"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00151">
        <property type="entry name" value="ispF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01350">
        <property type="entry name" value="ISPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000237729" description="2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="35"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="56"/>
            <end position="58"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>4-CDP-2-C-methyl-D-erythritol 2-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57919"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00107"/>
        </source>
    </evidence>
    <sequence length="157" mass="16890" checksum="B7C313E3018C1314" modified="2005-11-22" version="1">MRIGHGYDVHCLVEGRKLILGGVDVPYERGLLGHSDADVLLHAIADAILGALALGDIGKHFPDTDPQFKGADSRKLLRHVMALAGQKGYVLGNVDATIVAQRPKLAPFIPEMRANLAEDLIAEIDRINVKATTTEQLGFAGRGEGIAAYAVVLMERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZQ0</accession>
    <name>Q39ZQ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">3-deoxy-D-arabino-heptulosonate 7-phosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">aroG-1</name>
        <name evidence="3" type="ordered locus">Gmet_0024</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513790.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0024"/>
    <dbReference type="EnsemblBacteria" id="ABB30274">
        <property type="protein sequence ID" value="ABB30274"/>
        <property type="gene ID" value="Gmet_0024"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0024"/>
    <dbReference type="eggNOG" id="COG2876">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062599_0_0_7"/>
    <dbReference type="OMA" id="YRNIPEW"/>
    <dbReference type="OrthoDB" id="687380at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041071">
        <property type="entry name" value="DAHP_snth_FXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006268">
        <property type="entry name" value="DAHP_syn_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18152">
        <property type="entry name" value="DAHP_snth_FXD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01361">
        <property type="entry name" value="DAHP_synth_Bsub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAHP_snth_FXD" evidence="2">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="DAHP_synth_1" evidence="1">
        <location>
            <begin position="86"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="344" mass="36921" checksum="BCA387FC27BC1BB8" modified="2005-11-22" version="1">MLIVMIHKAGPKQIEAVVKAVETMGLTAAPIPGSERTAIGVLGNKGYVDDTTIRDLPGVQEVIHVSKPYKLVSRDFHPRNTIVKVCGISIGEGKRPVVVAGPCAVEGEEQILKTARAVKKAGADLLRGGAFKPRTGPHTFQGMREEGLKLLAKAREATGLPIVTEVMSPDTVGLVAEYADLLQVGARNMQNFELLKELGRIQKPVLLKRGMSATIEEFLAAAEYILAEGNPHVILCERGIRTFETATRNTLDLAVVPLIREMSHLPVMVDPSHATGKRSLVAPMAKAALVAGAHGVLIEVHPEPDKALSDGPQSLTFHGFDLLMEEIRRLNAFLGVDDGGEKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-09-29" version="32" xmlns="http://uniprot.org/uniprot">
    <accession>J7M089</accession>
    <name>J7M089_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transposase of ISGme7, IS3 family, OrfB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1183"/>
    <dbReference type="EnsemblBacteria" id="AFR42812">
        <property type="protein sequence ID" value="AFR42812"/>
        <property type="gene ID" value="Gmet_1183"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1183"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027402_6_1_7"/>
    <dbReference type="OMA" id="WAANQGI"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025948">
        <property type="entry name" value="HTH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13276">
        <property type="entry name" value="HTH_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13683">
        <property type="entry name" value="rve_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="111"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="289" mass="34189" checksum="5003FFB2114A7EB5" modified="2012-10-31" version="1">MKPARKRQLVEFLRVAFKVSERHACRLIRLQRSSQRYRHRRNEQIALRIRLKEHAAARPRFGYLRLHILLLREGWQINRKRVYRLYRLECLKLRHKKPKKRISALRVAHPAPQRPNECWSMDFVSDSLHDGRRFRALTIVDNVSRVSPAIEVGNSLSGRRVVDVLEGLAYTYGLPKVIQVDNGPEFTSKALDEWAHRRKIKLQVSRPGKPTDNPFIESFNGRLRQECLDQSWFISIEDAQMKTEEWRVDYNENRPHSSLENRAPSDFLDAWNQNQQTEKLTHLLDQKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-09-29" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEM8</accession>
    <name>J9JEM8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513230.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3596"/>
    <dbReference type="EnsemblBacteria" id="AFR42811">
        <property type="protein sequence ID" value="AFR42811"/>
        <property type="gene ID" value="Gmet_3596"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3596"/>
    <dbReference type="HOGENOM" id="CLU_2699437_0_0_7"/>
    <dbReference type="OMA" id="TEYNEFI"/>
    <dbReference type="OrthoDB" id="2099062at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="73" mass="8529" checksum="4C0B517959E3E6EC" modified="2012-10-31" version="1">MLSPKAREELKKAAASTELRDDMTAVAALKQPPWLRDGVVDADLWLDYLTEYNEFINHRRKPETPFIEIRMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PS1</accession>
    <name>Q39PS1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidylprolyl cis-trans isomerase lipoprotein, PpiC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3548</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33753.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513704.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3548"/>
    <dbReference type="EnsemblBacteria" id="ABB33753">
        <property type="protein sequence ID" value="ABB33753"/>
        <property type="gene ID" value="Gmet_3548"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3548"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_1_2_7"/>
    <dbReference type="OMA" id="WKDQIRY"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="3">
        <location>
            <begin position="150"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33753.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="315" mass="34363" checksum="852CE59636103B91" modified="2012-10-31" version="2">MKRTAVLTILSATLLAVPFTGCKGKTETGTATAPAKKAGEVIAEVNGDTITTGDFQKELENLPPYLKPMADTAEGKKELLDTMVVRELILQQARKDGLDKSPDVAAKLEELKKRVVVEAFLKKKVEEQAKVSDEEMKKFYEENKDKFKTGPQVHASHILMKSEDEAQKVLKELKEGGNFEELAKKHSIDSAAAKGGDLGWFSKGSMVPEFEKVVFGLKEGETSGIVKTKFGYHIIKLTGKRPAGIRTFDEVKEQLRAAILPSKQQEVFQKLKDDIKKGAKVTIKEDVLKGIGGAAAEKPAPAGPESTPAKKAETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PT1</accession>
    <name>Q39PT1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Biopolymer transport membrane protein, TolR-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_3538</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ExbD/TolR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513694.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3538"/>
    <dbReference type="EnsemblBacteria" id="ABB33743">
        <property type="protein sequence ID" value="ABB33743"/>
        <property type="gene ID" value="Gmet_3538"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3538"/>
    <dbReference type="eggNOG" id="COG0848">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085305_1_3_7"/>
    <dbReference type="OMA" id="MMTHGVK"/>
    <dbReference type="OrthoDB" id="1940365at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003400">
        <property type="entry name" value="ExbD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014168">
        <property type="entry name" value="Tol-Pal_TolR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30558">
        <property type="entry name" value="PTHR30558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02472">
        <property type="entry name" value="ExbD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02801">
        <property type="entry name" value="tolR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="139" mass="15039" checksum="372F2715E7DDF04E" modified="2005-11-22" version="1">MEIGSRNNGDRGTMSQINVTPMVDVMLVLLVIFMVTAPMMQQGVQVNLPKAETKAMATQEESVVVSIDRSGKVFINATEVAPGDLKGKLTSMVANRTKKEVFLKADRDVPYGDVVRTMAEIKGAGIERLGMVTEPAPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PW2</accession>
    <name>Q39PW2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Efflux pump, RND family, outer membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513663.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3507"/>
    <dbReference type="EnsemblBacteria" id="ABB33712">
        <property type="protein sequence ID" value="ABB33712"/>
        <property type="gene ID" value="Gmet_3507"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3507"/>
    <dbReference type="eggNOG" id="COG1538">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012817_14_3_7"/>
    <dbReference type="OMA" id="YGYLDYV"/>
    <dbReference type="OrthoDB" id="1533572at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015562">
        <property type="term" value="F:efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003423">
        <property type="entry name" value="OMP_efflux"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02321">
        <property type="entry name" value="OEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="110"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="435" mass="47114" checksum="EC16B1EDEEB08A38" modified="2005-11-22" version="1">MSRAYRFVPGAVHLLLASLVLSPQGASGEMHSLTLPQAVEYALVNNGELKALRAEKEVARAGLERAALFPNPTLELSGDTGALTGSSGENVVSIGLSQEFLTGGKRAKRRAVAEVEAEEVRQQIADRERTLALEVKSTFAEFMLAHKRRELAQRAVELNGKLLEITRERLAAGDIPELEVNLAQVELARSEGRKIETVRGLSPLLARLLTLLGLPTGDEVNLADSPERQPVTIPPDELTRLALENRPDLKALQAAHDRGDAAVELAEAERIPNVIVGVGYTHEQRVDATGVGEEKTRDNLLGMKLSIPLPVFDRNQAGILEARARAQSAGNRLEFARTGVAREIDGDYARLATADKALDLYTGGILPQLEENLKIIQEAYQLGEVGILSVIEEQKKYIEVHDGYLAALADRQTALARLEASVGVDFQNKTSGGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PX0</accession>
    <name>Q39PX0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidoglycan-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pal</name>
        <name evidence="12" type="ordered locus">Gmet_3499</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Pal lipoprotein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513656.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3499"/>
    <dbReference type="EnsemblBacteria" id="ABB33704">
        <property type="protein sequence ID" value="ABB33704"/>
        <property type="gene ID" value="Gmet_3499"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3499"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016890_9_0_7"/>
    <dbReference type="OMA" id="GCAKHEM"/>
    <dbReference type="OrthoDB" id="1544679at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02204">
        <property type="entry name" value="Pal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039001">
        <property type="entry name" value="Pal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014169">
        <property type="entry name" value="Pal_lipo_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02802">
        <property type="entry name" value="Pal_lipo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1 7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223412" description="Peptidoglycan-associated protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="11">
        <location>
            <begin position="79"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="194" mass="21024" checksum="D1903123C172363D" modified="2005-11-22" version="1">MRKMLCRVTMLSIGILAVAGCAKNETIKKDEMVPVASNKTAQAAVAKPAVKDGGIKTPPAKEVQSKDQSKEGAAKGTMTEAQLQAALTKIFFNFDSSVLSSEGRETLVKNAELLKSASFKVRIEGNCDERGSDEYNLALGERRAQAAMKYLLTMGVPADRLSIISYGEEKPADPGHDEAAWAKNRRDEFVVMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PX6</accession>
    <name>Q39PX6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nitric oxide reductase, cytochrome b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norZ</name>
        <name evidence="2" type="ordered locus">Gmet_3493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513650.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3493"/>
    <dbReference type="EnsemblBacteria" id="ABB33698">
        <property type="protein sequence ID" value="ABB33698"/>
        <property type="gene ID" value="Gmet_3493"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3493"/>
    <dbReference type="eggNOG" id="COG3256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021582_0_0_7"/>
    <dbReference type="OMA" id="VTRTWHT"/>
    <dbReference type="OrthoDB" id="133514at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004129">
        <property type="term" value="F:cytochrome-c oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.210.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036927">
        <property type="entry name" value="Cyt_c_oxase-like_su1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000883">
        <property type="entry name" value="Cyt_C_Oxase_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10422">
        <property type="entry name" value="PTHR10422"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00115">
        <property type="entry name" value="COX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81442">
        <property type="entry name" value="SSF81442"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="478"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="594"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="731"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="756" mass="83929" checksum="6DE09A543BD5B888" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PY1</accession>
    <name>Q39PY1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ion_trans_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513645.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3488"/>
    <dbReference type="EnsemblBacteria" id="ABB33693">
        <property type="protein sequence ID" value="ABB33693"/>
        <property type="gene ID" value="Gmet_3488"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3488"/>
    <dbReference type="eggNOG" id="ENOG502ZBBH">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063401_0_0_7"/>
    <dbReference type="OMA" id="GWRVNYE"/>
    <dbReference type="OrthoDB" id="994564at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Ion_trans_2" evidence="2">
        <location>
            <begin position="107"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="378" mass="42868" checksum="03DD454EEAD732B6" modified="2005-11-22" version="1">MTIVAVMCGIALIVVVLWEGFETIVLPRRVTRRFRMTRFFYRRTWLPWVTMVNACVPPRRRETWLSFFGPLSLILLLSIWAFGLIVGFALLHWGLGSAIVTHDGSSGLLVDLYLSGTTFFTLGLGDAIPRSTAARFLVVLESGMGFGFLALVIGYLPALNQSFASREVSISLLDARAGSPPTASEMLRRHGHERGMDALRQLLHEWENWSSEFLEGHLSYPVLAYFRSQHENQSWLGALTAILDTCALLMAGVDGACERQAELTFAMARHAVVDLSLVFRTRPQEPASPRLPPEKLEDLRALLAERGLKLRERDTVDRKLTELRWMYEPYVHALAAYFRVKVPPWIAAENQPDNWEVSVWDRRTVSRKVTEKAKGEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q13</accession>
    <name>Q39Q13_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513903.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3452"/>
    <dbReference type="EnsemblBacteria" id="ABB33661">
        <property type="protein sequence ID" value="ABB33661"/>
        <property type="gene ID" value="Gmet_3452"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3452"/>
    <dbReference type="eggNOG" id="COG1075">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_936149_0_0_7"/>
    <dbReference type="OMA" id="RYRGMMG"/>
    <dbReference type="OrthoDB" id="1598268at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223142" evidence="1">
        <location>
            <begin position="18"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="282" mass="29617" checksum="8422D0BC269CAA69" modified="2005-11-22" version="1">MKRVIVAVLIPMAVTIAGCGGGGGSSSPATTAISGTVADGYLIGAEVFLDKNGNYQWDSGEPKTTTDANGAYRMTVSAADASMYPVVVRAIAGTTIDKDTNTAVANGYVMSAPAGHPGFISPMTTLVREKMTANPAMTLTDAMTQLRNQMNLPEGIDVMADYMAQSQSGTNGASYQTMHSIAQQMAGLMGGQANLVMTGSSVQVNRYRGMMATINANMPGIAANVTNSPFMTTMMTTMQSQIGAIPTTGGFVNYSAMFRNMTSSRYFWSNTTPMTPMRGGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QI2</accession>
    <name>Q39QI2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_3279</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512717.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3279"/>
    <dbReference type="EnsemblBacteria" id="ABB33492">
        <property type="protein sequence ID" value="ABB33492"/>
        <property type="gene ID" value="Gmet_3279"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3279"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3605">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018526_0_0_7"/>
    <dbReference type="OMA" id="RINDVEC"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="397"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="361"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="608" mass="66803" checksum="394835A82FFAD108" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QM1</accession>
    <name>Q39QM1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ferric uptake regulation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fur</name>
        <name evidence="4" type="ordered locus">Gmet_3240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the Fur family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512679.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3240"/>
    <dbReference type="EnsemblBacteria" id="ABB33453">
        <property type="protein sequence ID" value="ABB33453"/>
        <property type="gene ID" value="Gmet_3240"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3240"/>
    <dbReference type="eggNOG" id="COG0735">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_096072_4_2_7"/>
    <dbReference type="OMA" id="DHPHADT"/>
    <dbReference type="OrthoDB" id="1630127at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07153">
        <property type="entry name" value="Fur_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002481">
        <property type="entry name" value="FUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043135">
        <property type="entry name" value="Fur_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33202">
        <property type="entry name" value="PTHR33202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01475">
        <property type="entry name" value="FUR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="148" mass="16693" checksum="47712A682BB1A0B4" modified="2005-11-22" version="1">MDCPLAFKKEKLRHLEDGCRQNGLAMTVQRRVVLDALAERTDHPSADQLYDAVRGRLRGISRTTVYRVLETLVGIGVVQKISNPESKARYDANTVRHHHIHCIRCEKIEDMHTPALHLAQQVPIATESGFTIVDYSINFSGICPDCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QS2</accession>
    <name>Q39QS2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512627.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3189"/>
    <dbReference type="EnsemblBacteria" id="ABB33402">
        <property type="protein sequence ID" value="ABB33402"/>
        <property type="gene ID" value="Gmet_3189"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3189"/>
    <dbReference type="eggNOG" id="ENOG50334XP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_147355_0_0_7"/>
    <dbReference type="OMA" id="YPGFYDP"/>
    <dbReference type="OrthoDB" id="1813963at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023824">
        <property type="entry name" value="CHP04073_exosortase-affil"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04073">
        <property type="entry name" value="exo_TIGR04073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="125" mass="13421" checksum="31030CA1BC8DEA52" modified="2005-11-22" version="1">MKPGRLITGAALACLLVCGQHQRVHAESITSVEDASAQEVVDGMANKFARGVANTATGWLEFPKQIYVTWQEEGPAKGLTVGPLKGVGMTVARTLAGAGEAVTFFISWPGFFDAYMDPAYVWEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QV2</accession>
    <name>Q39QV2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Alpha-glucan phosphorylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_3159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513875.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3159"/>
    <dbReference type="CAZy" id="GT35">
        <property type="family name" value="Glycosyltransferase Family 35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33372">
        <property type="protein sequence ID" value="ABB33372"/>
        <property type="gene ID" value="Gmet_3159"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3159"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015112_0_0_7"/>
    <dbReference type="OMA" id="LYRHGYF"/>
    <dbReference type="OrthoDB" id="137158at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011834">
        <property type="entry name" value="Agluc_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024517">
        <property type="entry name" value="Glycogen_phosphorylase_DUF3417"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11897">
        <property type="entry name" value="DUF3417"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02094">
        <property type="entry name" value="more_P_ylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3417" evidence="5">
        <location>
            <begin position="17"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="4">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="854" mass="96963" checksum="818D4BC1654B2C77" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R37</accession>
    <name>Q39R37_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33287.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3073"/>
    <dbReference type="EnsemblBacteria" id="ABB33287">
        <property type="protein sequence ID" value="ABB33287"/>
        <property type="gene ID" value="Gmet_3073"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3073"/>
    <dbReference type="eggNOG" id="COG3222">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075662_1_0_7"/>
    <dbReference type="OMA" id="IGTDCPG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018641">
        <property type="entry name" value="Trfase_1_rSAM/selenodom_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36529">
        <property type="entry name" value="PTHR36529"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09837">
        <property type="entry name" value="DUF2064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04282">
        <property type="entry name" value="glyco_like_cofC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33287.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="241" mass="26268" checksum="28CE65CA67CB5C7B" modified="2012-10-31" version="2">MQLRSLPPNPLCRMSKALIVFAKRPSPGRVKTRLTPPFSPEDAAKLYRCMLLDVLAKTGQMTGVDRLLFYEQGDGVPEFFAETVGEGESYPQEGDGLGARLAAAFDRTFGQGYDSAAVIGTDSPHLPPDYIEQAFDLLNDPRVDAVFGPTEDGGYYLLAMKRLHRELFEGIAWSTPEVLEQSLARAESAGIATALLPVWHDVDTAADLLRPELVDPGNGAPLTREFILRHPPHSPVAPGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RC7</accession>
    <name>Q39RC7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514473.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2982"/>
    <dbReference type="EnsemblBacteria" id="ABB33197">
        <property type="protein sequence ID" value="ABB33197"/>
        <property type="gene ID" value="Gmet_2982"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2982"/>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_796273_0_0_7"/>
    <dbReference type="OMA" id="ICGMATA"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="212"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="342" mass="37675" checksum="4B7D9DCCA4A70B35" modified="2005-11-22" version="1">MGCDILQEILDSCLSLEKKAAAIFRAFAAHAVRDDARSFWEAVAAETNHHSALYERLNTPISEGGAAPLVIYKPAETREELEMIGRNIDEQFELYQAAPTPEAACLLGFRLQLYLLHPAFASLCRMTKDVTGEDANDLGYGRYLRRFIDGIGICGMATAESELLGEALFRLWNEARQLAVQSHTDALTGVLTRAGFFQAVSPLAYAAQRNGNNAAIMLIDIDYFKLLGENYGHQTGDRVLQVVADTITSHLRRSDVVGRYDGDEFIVYLSPVEPASLKSVAENLRVQVEEATARIVPVTISIGVAQGTFGPDVDHSLEELVRKADECQMQAKYTGKNKVVMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RJ5</accession>
    <name>Q39RJ5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-aspartate oxidase</fullName>
            <ecNumber evidence="4">1.4.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ordered locus">Gmet_2911</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + O2 = H2O2 + iminosuccinate</text>
            <dbReference type="Rhea" id="RHEA:25876"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:77875"/>
            <dbReference type="EC" id="1.4.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:25877"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.16" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512847.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2911"/>
    <dbReference type="EnsemblBacteria" id="ABB33129">
        <property type="protein sequence ID" value="ABB33129"/>
        <property type="gene ID" value="Gmet_2911"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2911"/>
    <dbReference type="eggNOG" id="COG0029">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014312_8_4_7"/>
    <dbReference type="OMA" id="RLMGNAL"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00326"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008734">
        <property type="term" value="F:L-aspartate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044318">
        <property type="term" value="F:L-aspartate:fumarate oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005288">
        <property type="entry name" value="NadB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42716">
        <property type="entry name" value="PTHR42716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="10">
        <location>
            <begin position="90"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="531" mass="57956" checksum="CA97FB445A7CB9AF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RT8</accession>
    <name>Q39RT8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Response receiver sensor protein serine/threonine phosphatase, PP2C family, PAS and PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513986.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2818"/>
    <dbReference type="EnsemblBacteria" id="ABB33036">
        <property type="protein sequence ID" value="ABB33036"/>
        <property type="gene ID" value="Gmet_2818"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2818"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2208">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_426270_0_0_7"/>
    <dbReference type="OMA" id="ICMSVRS"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07228">
        <property type="entry name" value="SpoIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="SSF81606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="4">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="218"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="5">
        <location>
            <begin position="274"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="338"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="114"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="649" mass="70936" checksum="CA1A76B7AA2BFD86" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RY5</accession>
    <name>Q39RY5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter, periplasmic substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2771</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511690.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2771"/>
    <dbReference type="EnsemblBacteria" id="ABB32989">
        <property type="protein sequence ID" value="ABB32989"/>
        <property type="gene ID" value="Gmet_2771"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2771"/>
    <dbReference type="eggNOG" id="COG0226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_026228_7_1_7"/>
    <dbReference type="OMA" id="TIGACDW"/>
    <dbReference type="OrthoDB" id="1766296at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024370">
        <property type="entry name" value="PBP_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12849">
        <property type="entry name" value="PBP_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223032" evidence="1">
        <location>
            <begin position="26"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="PBP_domain" evidence="2">
        <location>
            <begin position="23"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="274" mass="30160" checksum="75E073170137E346" modified="2005-11-22" version="1">MERSLRIVLTFFVAVMMSAVTSSWAQDPPIVVAGSGTCIPIVRILAEEFQRFHPDMEVRVPPSVGSAGGVTAVADGAVEIGMVSRPLRTDEAEKRLAFKPFARTAIVFAVSPSVPDRDLSSADIVAIYRGQKNRWKNGRTIVVLTREPRDSGIAVLRGKIPGFGEAYDASRDKKFWATFYTDQEMNQALARSRDVLGITDRGAVVAEKLPVKVLSLNGVEPHDNNVRSGRYPLFKTLAFVHRPGTLSRTGTSFLRFVFSGRGRKILKTHGYLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RZ4</accession>
    <name>Q39RZ4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_2762</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511699.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2762"/>
    <dbReference type="EnsemblBacteria" id="ABB32980">
        <property type="protein sequence ID" value="ABB32980"/>
        <property type="gene ID" value="Gmet_2762"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2762"/>
    <dbReference type="eggNOG" id="COG3452">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_62_7"/>
    <dbReference type="OMA" id="KRIAIRH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009736">
        <property type="term" value="P:cytokinin-activated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0932">Cytokinin signaling pathway</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="11">
        <location>
            <begin position="99"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="345"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="293"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="558" mass="61049" checksum="AE9646EC072E6B9D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SG0</accession>
    <name>Q39SG0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2595</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366073.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32814">
        <property type="protein sequence ID" value="ABB32814"/>
        <property type="gene ID" value="Gmet_2595"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2595"/>
    <dbReference type="eggNOG" id="COG0727">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1728666_0_0_7"/>
    <dbReference type="OMA" id="GECTFLT"/>
    <dbReference type="OrthoDB" id="1517287at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="170" mass="18523" checksum="A884FE7F1198FC74" modified="2005-11-22" version="1">MRNSAMPNTPSITNNEDFSLCRACGGECCRTRPGIEAPARFLAAANPAEELARLLASGLWVLDRHYGVPYDPGKGETGDPDRIILYPRPATRRERAEGTLLVVPGAGECVLLGDEGCTLPFAERPRACQALEPASDFACTAAWTRFDAAREWRHHQDTVEGALALLDSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SI2</accession>
    <name>Q39SI2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase RhlE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">rhlE-2</name>
        <name evidence="10" type="ordered locus">Gmet_2573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513461.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2573"/>
    <dbReference type="EnsemblBacteria" id="ABB32792">
        <property type="protein sequence ID" value="ABB32792"/>
        <property type="gene ID" value="Gmet_2573"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2573"/>
    <dbReference type="eggNOG" id="COG0513">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003041_28_3_7"/>
    <dbReference type="OMA" id="EIKQESM"/>
    <dbReference type="OrthoDB" id="643629at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Q_MOTIF" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="229"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="369"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="451" mass="49395" checksum="29DE392A71CB8168" modified="2005-11-22" version="1">MEFKEFNLHPQVMAGVTAAGYTTPTPIQAQAIPTVMEGRDVMGLAQTGTGKTAAFALPILHRLAQGERGRVRALVIAPTRELAEQINDSFVTLGRQTRLRSVTVYGGVNVNPQIQKLKAGAEIVVACPGRLLDHMAQGTIDLSHLEVLVLDEADQMFDMGFLPDLRRILKQLPPKRQTLLFSATMPIDIRVLAQEILRDPVTVQVGTVAPAVTVTHALYPVEQHLKTPLLLELLRHTDTESVLIFTRTKHRAKRLGEQMEKAGYKAASLQGNLSQNRRQAALDGFRDGTFQILVATDIAARGIDVSQVSHVINYDIPDTAEAYIHRIGRTGRAARSGDAFTMVTSEDTAMVRTIERKLNTSLERRTMAGFDYSVPAPKKDTEFARPPRQPMPSRRPTEAKKGGARQGASHQPGSAKPAEGRRSQPQAAKANPARTAGTGGQRTGQQRRQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SJ9</accession>
    <name>Q39SJ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Lytic transglycosylase, SLT, LysM and LysM domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2556</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513478.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2556"/>
    <dbReference type="CAZy" id="GH23">
        <property type="family name" value="Glycoside Hydrolase Family 23"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32775">
        <property type="protein sequence ID" value="ABB32775"/>
        <property type="gene ID" value="Gmet_2556"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2556"/>
    <dbReference type="eggNOG" id="COG0741">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009520_1_3_7"/>
    <dbReference type="OMA" id="ARHMPTE"/>
    <dbReference type="OrthoDB" id="1444566at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008258">
        <property type="entry name" value="Transglycosylase_SLT_dom_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01464">
        <property type="entry name" value="SLT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="SSF54106"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223478" evidence="2">
        <location>
            <begin position="21"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="364"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="435"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="499" mass="55654" checksum="3F281D79794819BD" modified="2005-11-22" version="1">MKKALLLLVLCLFPVLPALASEPRNSPLKELAALGNSSSLPDLSGAVPSGFDSRPGRRSGSLEPSMGDLVVIEDQGAAENDFELKIPEGPLPDSDIPLTLNGQVEYFIRYFQSSGRKSFTRWLSRSERYIPMMKEVLKKNGLPEDLVYLAMIESGFTPHAVSVASAVGPWQFISGTGKRYDLRIDQWIDERRDPLKSTVAAALYLKELYAMFNNDWYLAAAGYNAGENKILRAIDRYNTRDFWEISKGSYLKRETKEYVPKLLAAAIIAKEPARYGFADVAYLPPIEFDTVTIPSRTDLEVAAKLCNVDYQVVKELNPELRRWCTPPDYPGYELKIPVGKKRAFEQAYAQLPEGQRYAERVVYTRYRAKKRDTLASIASRYGTTPQALAEVNKLKLSAKVRGRTLLVPVVADREPAVQTAKADVSRKESAKGFNKYYTVKKGDTIASLSKKFNISSRILTAWNSLKGKLALRPGKRIIVAKYVEKKGSMVPVSGGDDNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SN7</accession>
    <name>Q39SN7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514812.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2516"/>
    <dbReference type="EnsemblBacteria" id="ABB32737">
        <property type="protein sequence ID" value="ABB32737"/>
        <property type="gene ID" value="Gmet_2516"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2516"/>
    <dbReference type="eggNOG" id="COG3945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095978_2_0_7"/>
    <dbReference type="OMA" id="VRVKYVT"/>
    <dbReference type="OrthoDB" id="1701106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="5"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="188" mass="21076" checksum="8ACB9C61EA6CB951" modified="2005-11-22" version="1">MKRDITQALVEEHRLILRMLALLERNAPLTAAGRYTNFQFFRDAVDFIRSYADRFHHAKEEEILFEALITNGMPRENSPVAAMLMEHDQGRAYVKAMEEAALAAEGGDTSRTGALAENARAYLTLLREHIDKEDTILYPLAERVIPEGLREGIVGGYEAAEARTPAGFAEHYLHLVEQYEAEATAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SW8</accession>
    <name>Q39SW8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver CheY associated with MCPs of class 34H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheY34H-2</name>
        <name evidence="3" type="ordered locus">Gmet_2431</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512469.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2431"/>
    <dbReference type="EnsemblBacteria" id="ABB32656">
        <property type="protein sequence ID" value="ABB32656"/>
        <property type="gene ID" value="Gmet_2431"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2431"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_12_7"/>
    <dbReference type="OMA" id="IVEDEFT"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="131" mass="14815" checksum="53080C4E8FAB7ACA" modified="2005-11-22" version="1">MKTLIVEDDFVSRKIMKELITPLGECDIAIDGEEAVKAFRLAHEEKRPYDLVCMDIMMPNLDGHGALERMRELEREMGIACANEVRVIMTTALDDPKNVVDALYRGGATSYLVKPITRQKLLKEIRSHGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SZ1</accession>
    <name>Q39SZ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Efflux pump, RND family, membrane fusion protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512492.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2408"/>
    <dbReference type="EnsemblBacteria" id="ABB32633">
        <property type="protein sequence ID" value="ABB32633"/>
        <property type="gene ID" value="Gmet_2408"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2408"/>
    <dbReference type="eggNOG" id="COG0845">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018816_1_2_7"/>
    <dbReference type="OMA" id="ATANIIY"/>
    <dbReference type="OrthoDB" id="1432684at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032317">
        <property type="entry name" value="HlyD_D23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006143">
        <property type="entry name" value="RND_pump_MFP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16576">
        <property type="entry name" value="HlyD_D23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01730">
        <property type="entry name" value="RND_mfp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="HlyD_D23" evidence="3">
        <location>
            <begin position="79"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="404" mass="42759" checksum="87ECA899648CBAC9" modified="2005-11-22" version="1">MANEDLGKLKIDKGALARSGGRRRPRFWIVAAVAVVVLLILFVSGVLSPAVTVETGTVTQVYPSQAYTLLNASGYVVAQRKAAVAAKVTGRLDWLGVEEGSRVKQGEILARLENLDAAAARDQAAATVKTSRASLDQAKAELTDATLAFEREKQLLKEGIVAKAEYDSAEARYRRAKAAVTGASASIVASEAALRGAQVNLEYSFIRAPFDAVVLTKNADIGDIVTPIGAAANAKAAVVTIADLGSLQVEADVSESNLETVKVGQPCEIQLDALPEVRFKGRVHMVVPTADRSKATVLVKVRFEKLDPRILPEMSAKVAFLEHLVAPGEEKPKTAVNPAAVVERGGRKVLFLVKGGRVAETPVTVGAKIGEMLEITAGAKPGDKIALKPLDKLKDGTKIKTAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SZ4</accession>
    <name>Q39SZ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_2405</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512495.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2405"/>
    <dbReference type="EnsemblBacteria" id="ABB32630">
        <property type="protein sequence ID" value="ABB32630"/>
        <property type="gene ID" value="Gmet_2405"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2405"/>
    <dbReference type="eggNOG" id="COG0577">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_8_7"/>
    <dbReference type="OMA" id="IWGDADQ"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="344"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="9">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="8">
        <location>
            <begin position="286"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="387" mass="42105" checksum="EF409798C97ACD9B" modified="2005-11-22" version="1">MGIPYSYSFRNLWTRRLTTVLTASGMALVVFVFAATLMLAEGLRKTLVDTGSYDNVVVIRKSAQTEVQSGIDRSQAAVVETQPEIAVEGGERLVAKEIVVLISLPKRGSGKPSNVIIRGVSATSLLMRPQVKVIEGRMPRPGSAEIMAGASIAKRFKGGGIGETLRFGMRDWTVVGIFEAGNTGFSSEIWGDVDQLMQAFRRPVYSSIIFKLRDPSEFVRVKERIEGDPRLTLEAKREITFYADQSQAMAKFLRILGITLTIIFSLGAVIGAMITMYAAVANRVTEIGTLRALGFQRGSILAAFILESLFLGLLGGVVGLFFASFMQLVTISTMNWQTFSELAFTFSLTPGIIGKSLIFSLVMGFVGGLLPAFRAARMNIVDALRAT</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-07-28" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T32</accession>
    <name>LNT_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apolipoprotein N-acyltransferase</fullName>
            <shortName evidence="1">ALP N-acyltransferase</shortName>
            <ecNumber evidence="1">2.3.1.269</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">lnt</name>
        <name type="ordered locus">Gmet_2367</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a glycerophospholipid + N-terminal S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein] = a 2-acyl-sn-glycero-3-phospholipid + H(+) + N-acyl-S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[lipoprotein]</text>
            <dbReference type="Rhea" id="RHEA:48228"/>
            <dbReference type="Rhea" id="RHEA-COMP:14681"/>
            <dbReference type="Rhea" id="RHEA-COMP:14684"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136912"/>
            <dbReference type="ChEBI" id="CHEBI:140656"/>
            <dbReference type="ChEBI" id="CHEBI:140657"/>
            <dbReference type="ChEBI" id="CHEBI:140660"/>
            <dbReference type="EC" id="2.3.1.269"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; lipoprotein biosynthesis (N-acyl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.269" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513253.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T32"/>
    <dbReference type="SMR" id="Q39T32"/>
    <dbReference type="STRING" id="269799.Gmet_2367"/>
    <dbReference type="EnsemblBacteria" id="ABB32592">
        <property type="protein sequence ID" value="ABB32592"/>
        <property type="gene ID" value="Gmet_2367"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2367"/>
    <dbReference type="eggNOG" id="COG0815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019563_1_2_7"/>
    <dbReference type="OMA" id="IPQSMKW"/>
    <dbReference type="OrthoDB" id="1291198at2"/>
    <dbReference type="UniPathway" id="UPA00666"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016410">
        <property type="term" value="F:N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07571">
        <property type="entry name" value="ALP_N-acyl_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01148">
        <property type="entry name" value="Lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004563">
        <property type="entry name" value="Apolipo_AcylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045378">
        <property type="entry name" value="LNT_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20154">
        <property type="entry name" value="LNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00546">
        <property type="entry name" value="lnt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_1000164161" description="Apolipoprotein N-acyltransferase">
        <location>
            <begin position="1"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="CN hydrolase" evidence="1">
        <location>
            <begin position="239"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01148"/>
        </source>
    </evidence>
    <sequence length="521" mass="57386" checksum="D05A0A02F39CB574" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T33</accession>
    <name>Q39T33_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptide chain release factor 2</fullName>
            <shortName evidence="4">RF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 6" type="primary">prfB</name>
        <name evidence="6" type="ordered locus">Gmet_2366</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Methylated by PrmC. Methylation increases the termination efficiency of RF2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32591.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2366"/>
    <dbReference type="EnsemblBacteria" id="ABB32591">
        <property type="protein sequence ID" value="ABB32591"/>
        <property type="gene ID" value="Gmet_2366"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2366"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_221954_0_0_7"/>
    <dbReference type="OMA" id="YVFHPYQ"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016149">
        <property type="term" value="F:translation release factor activity, codon specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00094">
        <property type="entry name" value="Rel_fac_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004374">
        <property type="entry name" value="PrfB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00020">
        <property type="entry name" value="prfB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0488">Methylation</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="5">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="modified residue" description="N5-methylglutamine" evidence="4">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32591.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="372" mass="42035" checksum="A5F7B6D2E7D1E18C" modified="2012-10-31" version="2">MFREEVARVENLSERIAKLRGSLDIDSKREDIQEMEAHIAAPGFWDDNEKAQQLLRERTRIEKILELWDRLTRQADDIRVLIELGEEAGDEGTLDEVRALNDQLEKDVEGAEFQRMLSGTHDKNACYFSINAGAGGTEAQDWAEMLLRMYLRYCERKGWKTEITDYQGGDEAGVKSATFTVDGEYAYGYLKAEAGIHRLVRISPFDSNARRHTSFASVFAFPEIEDDIEVTINEADLRIDTYRSSGAGGQHVNTTDSAVRITHIPTGLVAASQCERSQHMNKATAMKMLRAKLYEKELQEREAKAAEIGGEKKEIGWGSQIRSYVLHPYKMVKDLRTGVETGNPDAVLDGDLEEFIVAFLMGVRRDVKDTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T40</accession>
    <name>Q39T40_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Lipoprotein release ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">lolE-1</name>
        <name evidence="11" type="ordered locus">Gmet_2359</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513261.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2359"/>
    <dbReference type="EnsemblBacteria" id="ABB32584">
        <property type="protein sequence ID" value="ABB32584"/>
        <property type="gene ID" value="Gmet_2359"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2359"/>
    <dbReference type="eggNOG" id="COG4591">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_8_1_7"/>
    <dbReference type="OMA" id="GWWQQNG"/>
    <dbReference type="OrthoDB" id="768211at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042953">
        <property type="term" value="P:lipoprotein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003838">
        <property type="entry name" value="ABC3_permease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011925">
        <property type="entry name" value="LolCE_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025857">
        <property type="entry name" value="MacB_PCD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02687">
        <property type="entry name" value="FtsX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12704">
        <property type="entry name" value="MacB_PCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02212">
        <property type="entry name" value="lolCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="MacB_PCD" evidence="10">
        <location>
            <begin position="25"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="FtsX" evidence="9">
        <location>
            <begin position="309"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="423" mass="46230" checksum="A81D2DB80E9C88A0" modified="2005-11-22" version="1">MSYELFIGLRYLKAKRKSTFISIITFISTAGVALGVMALIVVLAVMTGFEEDLKEKILGTNAHVVVLKSSGTMEDYPAIMERLKKMKGVVAATPFIYSQVMLSTGSNVSGVVLRGIDVKTDPLVTNLYRSLVEGKLGDLERSPLPLATPEPPKPGIIIGRELARSLNIYPGDTVNVISPLGNITPLGMVPKMKQFRVVGLFNTGMFEYDSTLAYVGLSEAQEFLSLGHAATGIQLRVQDVYRTGELVRKIDRELGFPFHARDWMQMNKNILFALKTEKMVMFVILTLIVLVAAFGIASTLFMVVLEKTKDIAILKSMGATGRSIMKIFVLEGLIIGISGTVIGVIGGLLVAYNLEPIVGVVQKVTGFELFSKDVYYLDHFPSRVVLSDVVLISVTAVLISLVATLYPSWQASKLPPAEALRYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TG5</accession>
    <name>Q39TG5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365987.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2232"/>
    <dbReference type="EnsemblBacteria" id="ABB32459">
        <property type="protein sequence ID" value="ABB32459"/>
        <property type="gene ID" value="Gmet_2232"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2232"/>
    <dbReference type="HOGENOM" id="CLU_2034726_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="SSF54427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="6"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="121" mass="13628" checksum="1AE98F1C3A56530A" modified="2005-11-22" version="1">METIIKKYFELVNSDSVDGLLELWNDNGTFDIPMLGVLKGKESFRKFYQSLPAMYAKHYDDPVKYVISGNEAVVKVVVTNTTPEGKTVVFNAFSWMTFSNGKLVSIEAKFDSAKLMKDLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TH6</accession>
    <name>Q39TH6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365976.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2221"/>
    <dbReference type="EnsemblBacteria" id="ABB32448">
        <property type="protein sequence ID" value="ABB32448"/>
        <property type="gene ID" value="Gmet_2221"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2221"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2522816_0_0_7"/>
    <dbReference type="OrthoDB" id="154149at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="84" mass="9489" checksum="5F22AC338C2E4DF2" modified="2005-11-22" version="1">MYLELITYTAEDGLELDAALYRQRGKGHAPDPLIILTHGASWMNFYTGPQRFLPRYLVLAGYDCLAINSRDRDIGYLHPPTGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TN9</accession>
    <name>Q39TN9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513049.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2156"/>
    <dbReference type="EnsemblBacteria" id="ABB32385">
        <property type="protein sequence ID" value="ABB32385"/>
        <property type="gene ID" value="Gmet_2156"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2156"/>
    <dbReference type="eggNOG" id="COG5492">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016488_0_0_7"/>
    <dbReference type="OMA" id="SCHANDA"/>
    <dbReference type="OrthoDB" id="39059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223506" evidence="1">
        <location>
            <begin position="25"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="543" mass="57099" checksum="3E1AE323B06345E9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TP0</accession>
    <name>Q39TP0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Multicopper oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513050.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2155"/>
    <dbReference type="EnsemblBacteria" id="ABB32384">
        <property type="protein sequence ID" value="ABB32384"/>
        <property type="gene ID" value="Gmet_2155"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2155"/>
    <dbReference type="eggNOG" id="COG2132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009100_4_0_7"/>
    <dbReference type="OMA" id="NGKSWPY"/>
    <dbReference type="OrthoDB" id="971126at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="PTHR11709"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="SSF49503"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plastocyanin-like" evidence="1">
        <location>
            <begin position="538"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="708" mass="75887" checksum="DC7335B7CDB6FD73" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TS2</accession>
    <name>Q39TS2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p-cresol methylhydroxylase, beta subunit cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pcmG</name>
        <name evidence="7" type="ordered locus">Gmet_2123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365921.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2123"/>
    <dbReference type="EnsemblBacteria" id="ABB32352">
        <property type="protein sequence ID" value="ABB32352"/>
        <property type="gene ID" value="Gmet_2123"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2123"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2000641_0_0_7"/>
    <dbReference type="OMA" id="MYCVMCH"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223386" evidence="5">
        <location>
            <begin position="32"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="32"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="132" mass="14665" checksum="9FE1A6EE942AB6A1" modified="2005-11-22" version="1">MRRERMNRKTSLIVAAALVFGMLLPGSGALAQEPPKMPYVFAMYCVMCHKEGVQIGPIGIYDMMSKSGNPLHEQLIRNNTRFGYNAMPAFRMSEVSPKEMNAIVAYLKDVAAYRKTHPGYKPVPAKEGGAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TV9</accession>
    <name>Q39TV9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Iron-sulfur cluster-binding oxidoreductase, putative benzoyl-CoA reductase electron transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bamC-1</name>
        <name evidence="2" type="ordered locus">Gmet_2086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5 6" key="3">
        <citation type="journal article" date="2015" name="Nat. Chem. Biol." volume="11" first="586" last="591">
            <title>Structural basis of enzymatic benzene ring reduction.</title>
            <authorList>
                <person name="Weinert T."/>
                <person name="Huwiler S.G."/>
                <person name="Kung J.W."/>
                <person name="Weidenweber S."/>
                <person name="Hellwig P."/>
                <person name="Stark H.J."/>
                <person name="Biskup T."/>
                <person name="Weber S."/>
                <person name="Cotelesage J.J."/>
                <person name="George G.N."/>
                <person name="Ermler U."/>
                <person name="Boll M."/>
            </authorList>
            <dbReference type="PubMed" id="26120796"/>
            <dbReference type="DOI" id="10.1038/nchembio.1849"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH IRON-SULFUR (4FE-4S)</scope>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514580.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="4Z3W">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.21 A"/>
        <property type="chains" value="E/F/G/H=1-179"/>
    </dbReference>
    <dbReference type="PDB" id="4Z3X">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="E/F/G/H=1-179"/>
    </dbReference>
    <dbReference type="PDB" id="4Z3Y">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.36 A"/>
        <property type="chains" value="E/F/G/H=1-179"/>
    </dbReference>
    <dbReference type="PDB" id="4Z3Z">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.67 A"/>
        <property type="chains" value="E/F/G/H=1-179"/>
    </dbReference>
    <dbReference type="PDB" id="4Z40">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="E/F/G/H=1-179"/>
    </dbReference>
    <dbReference type="PDBsum" id="4Z3W"/>
    <dbReference type="PDBsum" id="4Z3X"/>
    <dbReference type="PDBsum" id="4Z3Y"/>
    <dbReference type="PDBsum" id="4Z3Z"/>
    <dbReference type="PDBsum" id="4Z40"/>
    <dbReference type="SMR" id="Q39TV9"/>
    <dbReference type="DIP" id="DIP-61696N"/>
    <dbReference type="IntAct" id="Q39TV9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2086"/>
    <dbReference type="EnsemblBacteria" id="ABB32315">
        <property type="protein sequence ID" value="ABB32315"/>
        <property type="gene ID" value="Gmet_2086"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2086"/>
    <dbReference type="eggNOG" id="COG1142">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1486797_0_0_7"/>
    <dbReference type="OMA" id="EYDECGF"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12837">
        <property type="entry name" value="Fer4_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4 5 6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 5 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="1">
        <location>
            <begin position="77"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 7">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4 5 6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>Iron-sulfur (4Fe-4S)</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="4Z3W"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="4Z3X"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="4Z3Y"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="4Z3Z"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="4Z40"/>
        </source>
    </evidence>
    <sequence length="179" mass="20107" checksum="14CA45CBCAA48F2B" modified="2005-11-22" version="1">MNSETKKRIVKTINIDADKCNGCRACEVICSAFHAMPPYSSNNPARSRVRVVRDPLRDIYVPLYAGEYTESECIGRDKFIIDGKEYDECGFCRASCPSRDLFREPDSGLPLKCDLCDGEPEPLCVKWCLVGALSVTEREVEEPDESVKRTEMEIGLESLISRFGADVVADTVEQLTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TW5</accession>
    <name>Q39TW5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Benzoyl-CoA reductase electron transfer protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">bamH</name>
        <name evidence="13" type="ordered locus">Gmet_2080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514585.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2080"/>
    <dbReference type="EnsemblBacteria" id="ABB32309">
        <property type="protein sequence ID" value="ABB32309"/>
        <property type="gene ID" value="Gmet_2080"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2080"/>
    <dbReference type="eggNOG" id="COG1894">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014881_3_2_7"/>
    <dbReference type="OMA" id="AFMNRTL"/>
    <dbReference type="OrthoDB" id="688908at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="SSF140490"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="SSF142019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="559"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="12">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="635" mass="68599" checksum="E7895DDBF36F3DAE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TW7</accession>
    <name>Q39TW7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid aminotransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bamJ</name>
        <name evidence="2" type="ordered locus">Gmet_2078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514587.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2078"/>
    <dbReference type="DNASU" id="3739529"/>
    <dbReference type="EnsemblBacteria" id="ABB32307">
        <property type="protein sequence ID" value="ABB32307"/>
        <property type="gene ID" value="Gmet_2078"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2078"/>
    <dbReference type="eggNOG" id="COG0436">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052346_1_0_7"/>
    <dbReference type="OMA" id="VWGFRVG"/>
    <dbReference type="OrthoDB" id="417859at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotran_1_2" evidence="1">
        <location>
            <begin position="75"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="434" mass="48049" checksum="310C33D88FB4FE89" modified="2005-11-22" version="1">MNPLAVELNDLLAQHNPHVLEMLSDLGKNLFFPKGILTQSAEAKEKAHKFNATIGIATENGGPMYLQCIQDKLSAFDPKDIYPYAPPAGKPELRSLWREKMLRENPSQQGKHFSNPIVTNALTHGLSIAGDMFLDKGDHLILPDMLWGNYNLTFGTCCGAVIRKYPTFTATGGYDVDAFKAELKNSAEEKGKAVVLLNFPNNPSGYTPTVAEGDALVAAIKEVAEGGCNIVAITDDAYFGLFYEDSLKESLFGKLANLHPRILAVKLDGATKEEFVWGFRTGFITFADGNSYENTPVMTALEKKAMGIIRARISNCPHPSQTFAIEALRSPNFIKQKQEKFQVLKGRALKTKEVLNSGKYDKAWDYYPFNSGYFMCLKLKTVDAEKLRVHMLDKYGVGAISIGKTDLRIAFSCIDEKDIPELFATIHQAVQDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TZ5</accession>
    <name>Q39TZ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, UPF0118 superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514054.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2050"/>
    <dbReference type="EnsemblBacteria" id="ABB32279">
        <property type="protein sequence ID" value="ABB32279"/>
        <property type="gene ID" value="Gmet_2050"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2050"/>
    <dbReference type="eggNOG" id="COG0628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031275_8_0_7"/>
    <dbReference type="OMA" id="WRTLTAY"/>
    <dbReference type="OrthoDB" id="944044at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002549">
        <property type="entry name" value="AI-2E-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21716">
        <property type="entry name" value="PTHR21716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01594">
        <property type="entry name" value="AI-2E_transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="368" mass="40417" checksum="587A38F61C1DAFFF" modified="2005-11-22" version="1">MRLAGSYFSVTTYLKEYSPFIIVGVLVLAGLFFAWSLSSIFLPVLLALILAYVLNPVVSWLEGKRVPRVVVILLVMTGIVVGFAGAFAFFAGSIQNELAAVQINLPDYANRFYGLIPEKVKVYLQIETPDKLYRQVDRMLNELRGISFDIARGAYDFVKKAFSSTLGFILTVVGYFITPVYLYYFLADLPHFKEGALKLVPERSRETVTGLGDEIDGVLSAFVRGQLSVCVILAVLYSIGLSLIGIDLAIAIGTLSGILFIIPYVGTIFGIVVSMIMAFLKFHDLLHPLLCLGWFVIVQAIEGALITPAIVGNRVGLHPVVAIIALFIGGQWFGIFGMLLAVPVAAVLKVFLRHLTGWYLTTPFYRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U00</accession>
    <name>Q39U00_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin-dependent oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514059.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2045"/>
    <dbReference type="EnsemblBacteria" id="ABB32274">
        <property type="protein sequence ID" value="ABB32274"/>
        <property type="gene ID" value="Gmet_2045"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2045"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051479_0_0_7"/>
    <dbReference type="OMA" id="IEWRARF"/>
    <dbReference type="OrthoDB" id="1079953at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="351" mass="38510" checksum="3C02097A6E7E4DB5" modified="2005-11-22" version="1">MKYREILEAAVRAPSGENCQPWRFVMEGDVIRIFNIPDQDTSLFNLHQRASYVAHGALLENLSIAAPAFGYAPDISLFPDSHVPNLVAAVRMTEGPSFDDSLYPYIPKRCTNRKRYNGGALSAAESQTLLSVAERVPGGKVALTGSVQDKAEVAEVNALNDRLVFENEHLHAFLFEHVRWSDAEARERGDGLDIKTLELAPPDSLAFPLLKSWPLVDFLKNFGVPRIIAGSARKLALSAAAIGVVSVPGKGDKDCIAAGRLIERVWLEATKLGLSFQLMTGITLLMRRVLDGETENISSQHGELIKKAYGTLANRFGVEDGSLFIMFRVGRCGPPSVYSMRYPIDKVIDAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U16</accession>
    <name>Q39U16_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Polysaccharide chain length determinant protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512921.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2029"/>
    <dbReference type="EnsemblBacteria" id="ABB32258">
        <property type="protein sequence ID" value="ABB32258"/>
        <property type="gene ID" value="Gmet_2029"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2029"/>
    <dbReference type="eggNOG" id="COG3206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009912_5_2_7"/>
    <dbReference type="OMA" id="ERYEMAQ"/>
    <dbReference type="OrthoDB" id="1184929at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032807">
        <property type="entry name" value="GNVR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014345">
        <property type="entry name" value="PEP-CTERM_polysacc_chain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13807">
        <property type="entry name" value="GNVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03007">
        <property type="entry name" value="pepcterm_ChnLen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="GNVR" evidence="3">
        <location>
            <begin position="354"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="518" mass="59012" checksum="A199E2034AC5FFFA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U25</accession>
    <name>Q39U25_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase, AMP-forming</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512930.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2020"/>
    <dbReference type="EnsemblBacteria" id="ABB32249">
        <property type="protein sequence ID" value="ABB32249"/>
        <property type="gene ID" value="Gmet_2020"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2020"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_7"/>
    <dbReference type="OMA" id="AVWSGDT"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017529">
        <property type="entry name" value="AcylCoA_ligase_PEP_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03098">
        <property type="entry name" value="ligase_PEP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="12"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="433"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="523" mass="58963" checksum="F85F1C4E13F476BF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U28</accession>
    <name>Q39U28_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FemAB superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512933.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2017"/>
    <dbReference type="EnsemblBacteria" id="ABB32246">
        <property type="protein sequence ID" value="ABB32246"/>
        <property type="gene ID" value="Gmet_2017"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2017"/>
    <dbReference type="eggNOG" id="COG5653">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046277_0_0_7"/>
    <dbReference type="OMA" id="TRGFYTE"/>
    <dbReference type="OrthoDB" id="1856290at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038740">
        <property type="entry name" value="BioF2-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13480">
        <property type="entry name" value="Acetyltransf_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyltransf_6" evidence="1">
        <location>
            <begin position="182"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="369" mass="42426" checksum="F97C790B19DCE58A" modified="2005-11-22" version="1">MSAEYSVVIIDNLSGFSRIQQEWDALASQYHDEYFFLSHGWYGLWLNYFLKGSRLCIVTVYKGDRLVAIAPFLGKVERIKRIPVRKLESIGNAYSPLRSLIIDRSESKQRLGEFLFQALRKVPGWDIAQIGPLYDGELYSQAMDLLHYSGCNWLHKAVDCNWRLPCEGLAYEGYLKCRDKGVRQEIKRRNKKLGELGSIEIKIVKGHEAAAYMADYSDVYEKSWKQAEHLGPGFHVDLGEIAARGNNLLLALMYLDGQPIAAQYRILCGDKCFFLKTAYDSRYKRYSVGLVLLNHVLQYLMDSEQVKMVDFGPGNETYKSDWAEIKGNYTNFYLFNKTIKGVLAHFAYTKVNPIVKRFGKRLEEEGHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U60</accession>
    <name>Q39U60_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fusA-1</name>
        <name evidence="8" type="ordered locus">Gmet_1985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512966.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1985"/>
    <dbReference type="EnsemblBacteria" id="ABB32214">
        <property type="protein sequence ID" value="ABB32214"/>
        <property type="gene ID" value="Gmet_1985"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1985"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_7"/>
    <dbReference type="OMA" id="KPKIAYR"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="7"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="697" mass="77621" checksum="813659F430DE28F1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U85</accession>
    <name>Q39U85_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tryptophan--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">trpS</name>
        <name evidence="9" type="ordered locus">Gmet_1960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511884.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1960"/>
    <dbReference type="EnsemblBacteria" id="ABB32189">
        <property type="protein sequence ID" value="ABB32189"/>
        <property type="gene ID" value="Gmet_1960"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1960"/>
    <dbReference type="eggNOG" id="COG0180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029244_0_0_7"/>
    <dbReference type="OMA" id="GWGQFKP"/>
    <dbReference type="OrthoDB" id="951354at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="328" mass="37144" checksum="D11C61A231506025" modified="2005-11-22" version="1">MSNKRIVSGMRPTGKLHLGHFHGVLANWRELQEEYECFFFAADWHSLTTEYDNTAGIRQNTDEMILDWLAFGVDPAKCVIFRQSRVPQHAELNLILSMITPVSWLERNPTYKEMQENLSTKDLSTFGFLGYPVLMASDIIVYKASKVPVGHDQLPHLEITREIARRFNYLYNREVFPEPAALLTETPKVLGLDGRKMSKSYGNAIFLSESAEETRKKVMSMVTDTQRVRRSDPGEPDRCVAFSLNSLYLPEEKKADIYAGCRSAAIGCVECKKLQAEYLVQTLAPYRARRDELTEKPGLVAEILAEGEARAATEAARTMAEVRDALNL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UH3</accession>
    <name>CLPX_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP-dependent Clp protease ATP-binding subunit ClpX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">clpX</name>
        <name type="ordered locus">Gmet_1872</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ClpX chaperone family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511973.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UH3"/>
    <dbReference type="SMR" id="Q39UH3"/>
    <dbReference type="STRING" id="269799.Gmet_1872"/>
    <dbReference type="EnsemblBacteria" id="ABB32101">
        <property type="protein sequence ID" value="ABB32101"/>
        <property type="gene ID" value="Gmet_1872"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1872"/>
    <dbReference type="eggNOG" id="COG1219">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014218_8_2_7"/>
    <dbReference type="OMA" id="HYKRVQA"/>
    <dbReference type="OrthoDB" id="718259at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00175">
        <property type="entry name" value="ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004487">
        <property type="entry name" value="Clp_protease_ATP-bd_su_ClpX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046425">
        <property type="entry name" value="ClpX_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010603">
        <property type="entry name" value="Znf_CppX_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038366">
        <property type="entry name" value="Znf_CppX_C4_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06689">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00994">
        <property type="entry name" value="zf-C4_ClpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00382">
        <property type="entry name" value="clpX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51902">
        <property type="entry name" value="CLPX_ZB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_1000024561" description="ATP-dependent Clp protease ATP-binding subunit ClpX">
        <location>
            <begin position="1"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="ClpX-type ZB" evidence="2">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="119"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01250"/>
        </source>
    </evidence>
    <sequence length="417" mass="46055" checksum="7BA79E37F54B8792" modified="2005-11-22" version="1">MSRRNDSSENLTCSFCGKSQDEVKKLIAGPTVYICDECIELCNDIIAEESKLEEAMGPDVKKLPKPREIKDVLDEYVIGQDRAKKILAVAVYNHYKRIESMGKPSDVEMQKSNILLLGPTGSGKTLLAQTLARILRVPFAMADATNLTEAGYVGEDVENIILNLLQAADYDVERAQKGIIYIDEIDKIARKSDSPSITRDVSGEGVQQALLKIIEGTVASVPPKGGRKHPQQEFLKVDTSNILFICGGAFAGLDNIIQQRIGVKTLGFGADVKSKVEKKAGELLTDVTPEDLLKFGFIPEFIGRLPVLATLHELDEAAMVQILKEPKSALVKQYQKLFEMEHVKLKFTDGSLVAIAREALKRKTGARGLRSILENAMLDIMYEIPSQTMVKEVVISEDVIYNREKPIIVYESVAESA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UK8</accession>
    <name>IF1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Translation initiation factor IF-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">infA</name>
        <name type="ordered locus">Gmet_1837</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IF-1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512009.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UK8"/>
    <dbReference type="SMR" id="Q39UK8"/>
    <dbReference type="STRING" id="269799.Gmet_1837"/>
    <dbReference type="EnsemblBacteria" id="ABB32066">
        <property type="protein sequence ID" value="ABB32066"/>
        <property type="gene ID" value="Gmet_1837"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1837"/>
    <dbReference type="eggNOG" id="COG0361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_151267_1_0_7"/>
    <dbReference type="OMA" id="ECLRSAM"/>
    <dbReference type="OrthoDB" id="2066663at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04451">
        <property type="entry name" value="S1_IF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00075">
        <property type="entry name" value="IF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004368">
        <property type="entry name" value="TIF_IF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33370">
        <property type="entry name" value="PTHR33370"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00008">
        <property type="entry name" value="infA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0396">Initiation factor</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000263805" description="Translation initiation factor IF-1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="S1-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00075"/>
        </source>
    </evidence>
    <sequence length="72" mass="8173" checksum="51898101AF40E8A7" modified="2005-11-22" version="1">MSKEEAIEVEGTVIEPLPNAMFRVELENGHVVLAHISGKMRKYFIKILPGDKVTVELSPYDLSRGRITYRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UN1</accession>
    <name>Q39UN1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Menaquinol oxidoreductase complex ACIII, cytochrome c subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">actE</name>
        <name evidence="7" type="ordered locus">Gmet_1814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512032.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1814"/>
    <dbReference type="EnsemblBacteria" id="ABB32043">
        <property type="protein sequence ID" value="ABB32043"/>
        <property type="gene ID" value="Gmet_1814"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1814"/>
    <dbReference type="eggNOG" id="COG2010">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_088548_1_1_7"/>
    <dbReference type="OMA" id="GFGRMPP"/>
    <dbReference type="OrthoDB" id="1939800at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13442">
        <property type="entry name" value="Cytochrome_CBB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223151" evidence="5">
        <location>
            <begin position="19"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="6">
        <location>
            <begin position="66"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="151" mass="16579" checksum="0E29C189DECA0E7F" modified="2005-11-22" version="1">MRRAVKLAILTATPVLMAAIWMDEQPAYKPYQAPVLAPPKGAVPVTGKENVSQEFVEKNPVAPTVESLEQGETLFAINCSLCHGLSSAERGPVGKKLTPHPPGLDHDMVQGLSDSDIFRAITSGFGRMPPFQGKLTVQDRWNLINYLRTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UN5</accession>
    <name>Q39UN5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Menaquinol oxidoreductase complex ACIII, molybdopterin-binding-like subunit ActB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">actB1</name>
        <name evidence="6" type="ordered locus">Gmet_1810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512036.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1810"/>
    <dbReference type="EnsemblBacteria" id="ABB32039">
        <property type="protein sequence ID" value="ABB32039"/>
        <property type="gene ID" value="Gmet_1810"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1810"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_7"/>
    <dbReference type="OMA" id="EGNDEHP"/>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="2 4" id="KW-0408">Iron</keyword>
    <keyword evidence="3 4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="5">
        <location>
            <begin position="45"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="730" mass="78469" checksum="F561CD390E4F52C8" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UR4</accession>
    <name>Q39UR4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Redox-active membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513324.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1779"/>
    <dbReference type="EnsemblBacteria" id="ABB32010">
        <property type="protein sequence ID" value="ABB32010"/>
        <property type="gene ID" value="Gmet_1779"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1779"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046133_0_0_7"/>
    <dbReference type="OMA" id="VKDYFFT"/>
    <dbReference type="OrthoDB" id="1223448at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="425" mass="46165" checksum="9A059501591867CB" modified="2005-11-22" version="1">MGRGVVRLFILAGVLIVLLMTLTATGAAGSIGPKGEVTLYFFWGEGCPHCAKARPFLDDLRRKHPGLQVCDYEVLSNRKNVDILMAMAKKRGFEATGVPVFIIGNHVIAGFSEEKARDIEQKVSVELAGREATAPPATNSPPAGETITIPGICTVNPAAMSLPVFTVVIAALDSFNPCAFFVLFFLLSLMIHAHSRNRMALVGGTFVLFSGLVYFLFMAAWLNLFLLTGTLAAVTTAAGIIALMVAVINIKDFFFFEKGISLVIPEEKKPKLFERMRHLVHTGTLPSMLAGTVVLAVAANSYELLCTAGFPMVYTRLLTLRALPSSEYYLYLAFYNLIYVIPLAVIVAIFTATLGSRKLTEWQGRVLKLLSGIMMLMLGLVILLKPTLLNNALASLVLMAVALSVTAIIAVVAHRMSRQTEKPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UR6</accession>
    <name>Q39UR6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">ATP-dependent DNA helicase RecG</fullName>
            <ecNumber evidence="3 6">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6 9" type="primary">recG</name>
        <name evidence="9" type="ordered locus">Gmet_1777</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the helicase family. RecG subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3 6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513326.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1777"/>
    <dbReference type="EnsemblBacteria" id="ABB32008">
        <property type="protein sequence ID" value="ABB32008"/>
        <property type="gene ID" value="Gmet_1777"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1777"/>
    <dbReference type="eggNOG" id="COG1200">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005122_7_1_7"/>
    <dbReference type="OMA" id="DNGFQAC"/>
    <dbReference type="OrthoDB" id="234717at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004609">
        <property type="entry name" value="ATP-dep_DNA_helicase_RecG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045562">
        <property type="entry name" value="RecG_dom3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033454">
        <property type="entry name" value="RecG_wedge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19833">
        <property type="entry name" value="RecG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17191">
        <property type="entry name" value="RecG_wedge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00643">
        <property type="entry name" value="recG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 6" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="353"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="533"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="767" mass="84775" checksum="0671765FC378990A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39US8</accession>
    <name>Q39US8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1765</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1765"/>
    <dbReference type="EnsemblBacteria" id="ABB31996">
        <property type="protein sequence ID" value="ABB31996"/>
        <property type="gene ID" value="Gmet_1765"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1765"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_15_7"/>
    <dbReference type="OMA" id="GWRISAM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="95"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="7">
        <location>
            <begin position="341"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="462" mass="50994" checksum="84C080908F3F8E86" modified="2005-11-22" version="1">MSRLGVIIDLAICCHRHKEPAHPLQAKYSASRGTPTVTQTGTTAVTDADRIVELEHLLVELKAELAERKNIERDLKRAKVSAEAACHSKEDLLALVSHEIRSQIQMLTGAVELLRETPLDKKQTEYLNAFNHAGEFLLSLVNDLLDNSRLDAGRIHLDQIEFPFRELLERTAQLIAWQAGRKGLELEYHLSPDIPAQLVGDPKRLQQVILNLAGNAIKFTEQGKIIITVEPEASSLASQEMQLIFTIQDTGIGIPGDKLEEIFERYAQASPATFRTYGGTGLGLNIAKRLVGLMGGTIRVTSKEGKGTSFVFNARLGVTPPLLSSAVERRKSKSLPERSLRILLAEDAAEIRMLLGAFLGTTSHAVDMAHNGEEALKKFTSSNYDVIIMDIQMPVMDGLSATRKIREWERTHDRTPVPVVALTAGPERSDYLRAREAGCTTHLAKPIKKELLLNTISAVVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UV0</accession>
    <name>Q39UV0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31974.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1743"/>
    <dbReference type="EnsemblBacteria" id="ABB31974">
        <property type="protein sequence ID" value="ABB31974"/>
        <property type="gene ID" value="Gmet_1743"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1743"/>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="PKYLFCD"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="47"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="79"/>
            <end position="86"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31974.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="290" mass="31925" checksum="BAC19031D4194BC9" modified="2012-10-31" version="2">MFLKSLMEPKEEGGLFQKLMHGLAGSIFHGEQANSRIDLSDTRGVSIRIENLNKHFGDKHVLRDVNLEIRSGETFAIIGPSGTGKSVLLRHIVKLVRPDNGEIYIDGHPIFAANGEETTANYRYSMVFQSSALFNSLTVGENVGLWLREKRVCKEQRIGEIIREKLAMVGLEGTEELKTSELSGGMKKRVAIARSLAMNPDLILYDEPTAELDPVTTDELANTIIRLKETTKNTTVIVTHDLNFALYVADRIAMMHGGTIVGAGTPAEIKASENPIIKGFIYTTTKGIKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-03-24" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V17</accession>
    <name>GLPK_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol kinase</fullName>
            <ecNumber evidence="1">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Glycerokinase</fullName>
            <shortName evidence="1">GK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">glpK</name>
        <name type="ordered locus">Gmet_1676</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21644"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.30"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Inhibited by fructose 1,6-bisphosphate (FBP).</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FGGY kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511388.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V17"/>
    <dbReference type="SMR" id="Q39V17"/>
    <dbReference type="STRING" id="269799.Gmet_1676"/>
    <dbReference type="EnsemblBacteria" id="ABB31907">
        <property type="protein sequence ID" value="ABB31907"/>
        <property type="gene ID" value="Gmet_1676"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1676"/>
    <dbReference type="eggNOG" id="COG0554">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009281_2_3_7"/>
    <dbReference type="OMA" id="FMLMNIG"/>
    <dbReference type="OrthoDB" id="233605at2"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0000250"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00186">
        <property type="entry name" value="Glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="Carb_kinase_FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="Carb_kinase_FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0319">Glycerol metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000098734" description="Glycerol kinase">
        <location>
            <begin position="1"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="82"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="408"/>
            <end position="412"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00186"/>
        </source>
    </evidence>
    <sequence length="496" mass="53061" checksum="715F4D77D0119A85" modified="2005-11-22" version="1">MSYILALDQGTTSSRAIVFDTTATIRAIAQREFRQIFPRPGWVEHDGREIWATQVGVAAEALTRAGISPREVRAIGITNQRETTLLWDRRSGEPLHNAIVWQDRRTAELCDRLKADGLEPLFRQKTGLVLDAYFSGTKLAWLLEAIPGARSRAEAGELAFGTVDSWLAWNLSGGKLHVTDASNASRTLLFNITTLDWDDELLAILGIPRAVLPRVVDSGAVYGETAGDIFAAAIPLAGMAGDQQAALFGQACGTAGMAKNTYGTGCFLLMHCGTRPIESRHNLLTTVAWQLGGRAEYALEGSVFVAGAAVQWLRDGLGIIRSSGEVEALAASVPDSGGVCLVPAFTGLGAPHWDPYARGTIVGITRGTTAAHIARATLESIAFQSADLLTAMEADAGISLAELRVDGGATANGLLMQFQADLLGVPVVRPRISETTALGAAYLAGLAVGLWRDRQEIAGHWQVDRIFEPAMGREQAAELRGRWGRAVERARGWAAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-10-02" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V50</accession>
    <name>PANC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pantothenate synthetase</fullName>
            <shortName evidence="1">PS</shortName>
            <ecNumber evidence="1">6.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Pantoate--beta-alanine ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Pantoate-activating enzyme</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">panC</name>
        <name type="ordered locus">Gmet_1643</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
            <dbReference type="ChEBI" id="CHEBI:29032"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantothenate from (R)-pantoate and beta-alanine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">The reaction proceeds by a bi uni uni bi ping pong mechanism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the pantothenate synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511421.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V50"/>
    <dbReference type="SMR" id="Q39V50"/>
    <dbReference type="STRING" id="269799.Gmet_1643"/>
    <dbReference type="EnsemblBacteria" id="ABB31874">
        <property type="protein sequence ID" value="ABB31874"/>
        <property type="gene ID" value="Gmet_1643"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1643"/>
    <dbReference type="eggNOG" id="COG0414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047148_0_0_7"/>
    <dbReference type="OMA" id="CNHKLEP"/>
    <dbReference type="OrthoDB" id="1661843at2"/>
    <dbReference type="UniPathway" id="UPA00028">
        <property type="reaction ID" value="UER00005"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004592">
        <property type="term" value="F:pantoate-beta-alanine ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00560">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00158">
        <property type="entry name" value="PanC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003721">
        <property type="entry name" value="Pantoate_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042176">
        <property type="entry name" value="Pantoate_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21299:SF1">
        <property type="entry name" value="PTHR21299:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02569">
        <property type="entry name" value="Pantoate_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00018">
        <property type="entry name" value="panC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0566">Pantothenate biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000305458" description="Pantothenate synthetase">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>beta-alanine</name>
            <dbReference type="ChEBI" id="CHEBI:57966"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>(R)-pantoate</name>
            <dbReference type="ChEBI" id="CHEBI:15980"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="184"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00158"/>
        </source>
    </evidence>
    <sequence length="283" mass="31106" checksum="F1AE4C485F051289" modified="2005-11-22" version="1">MRIIETVAEMQAFSREARREGKSISLVPTMGFLHEGHASLMIEGKKRADILVTSIFVNPTQFGPTEDFDAYPRDLARDRNVAETAGVDVIFAPKASDMYPRGFQTYVNVEELTRPLCGASRPGHFQGVTTVVAKLLNIVLPHVALFGKKDFQQLAVIRRMAADLNMDVEIVGMPIVREADGLAMSSRNAYLGPEERKNALCLSRALATARDLFLDGERSVGTLRDKVLRVIGEVPGAVIDYADFRDGDTLETVETANGRTLIALAVKIGKTRLIDNCILGEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V97</accession>
    <name>Q39V97_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">tRNA (N6-threonylcarbamyl-A37) modification ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yrdC</name>
        <name evidence="2" type="ordered locus">Gmet_1595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511470.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1595"/>
    <dbReference type="EnsemblBacteria" id="ABB31827">
        <property type="protein sequence ID" value="ABB31827"/>
        <property type="gene ID" value="Gmet_1595"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1595"/>
    <dbReference type="eggNOG" id="COG0009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031397_3_0_7"/>
    <dbReference type="OMA" id="MLYPTDT"/>
    <dbReference type="OrthoDB" id="1913202at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="YrdC-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="SSF55821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00057">
        <property type="entry name" value="TIGR00057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YrdC-like" evidence="1">
        <location>
            <begin position="12"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="203" mass="22265" checksum="313789A6CA7EFE9E" modified="2005-11-22" version="1">MLLDINPQNPQPRLVAQVVKILKDGGIIAYPTDTTYGIGCSIFSKKGIERIYLLKQREKKKPFSFICSDLSEVARYAKVSNYAYKMLKRHLPGPYTFVLDATSIVPDLLVTKQKTVGIRIPDNRICLSLVKELGHPIITTSANLSGEEPIGDPYLVDLNMGKQLDVVVDGGILSADVSSVVSLIGDYPQVLRQGVGDVSWCEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VB1</accession>
    <name>Q39VB1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent dethiobiotin synthetase BioD</fullName>
            <ecNumber evidence="5">6.3.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DTB synthetase</fullName>
            <shortName evidence="5">DTBS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Dethiobiotin synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">bioD</name>
        <name evidence="6" type="ordered locus">Gmet_1581</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(7R,8S)-7,8-diammoniononanoate + ATP + CO2 = (4R,5S)-dethiobiotin + ADP + 3 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:149469"/>
            <dbReference type="ChEBI" id="CHEBI:149473"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the dethiobiotin synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="6.3.3.3" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511484.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1581"/>
    <dbReference type="EnsemblBacteria" id="ABB31813">
        <property type="protein sequence ID" value="ABB31813"/>
        <property type="gene ID" value="Gmet_1581"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1581"/>
    <dbReference type="eggNOG" id="COG0132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072551_3_1_7"/>
    <dbReference type="OMA" id="SPHWAAE"/>
    <dbReference type="OrthoDB" id="1739932at2"/>
    <dbReference type="UniPathway" id="UPA00078">
        <property type="reaction ID" value="UER00161"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004141">
        <property type="term" value="F:dethiobiotin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009102">
        <property type="term" value="P:biotin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00336">
        <property type="entry name" value="BioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004472">
        <property type="entry name" value="DTB_synth_BioD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43210">
        <property type="entry name" value="PTHR43210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006755">
        <property type="entry name" value="DTB_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00347">
        <property type="entry name" value="bioD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5" id="KW-0093">Biotin biosynthesis</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="5">
        <location>
            <position position="38"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="13"/>
            <end position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="115"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="205"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="241" mass="25575" checksum="4502A6595F02D30A" modified="2005-11-22" version="1">MSNAIFITGTDTGVGKTIVTATLACLLRKQGINVGVMKPVTSGCVEQNGSLVSEDAELLAWAAGVPLDEECAPYCLRTPIAPSVAASRENVRIDFSRIRNAYESLLARHDFVLVEGAGGLMVPLSGGLMVADLALALKLPLLVVARPNLGTINHTVLTCFAAKQLGIEVRGTIINSYPDRPDTAEEYAPHLIDSLSGAPLLGVFPKVEAADQRTIVETLTNHLSGQGTTKILLREIGIEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VD2</accession>
    <name>Q39VD2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Cysteine synthase</fullName>
            <ecNumber evidence="5 11">2.5.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">cysK-2</name>
        <name evidence="13" type="ordered locus">Gmet_1558</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>hydrogen sulfide + O-acetyl-L-serine = acetate + L-cysteine</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 9 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5 11"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511507.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1558"/>
    <dbReference type="EnsemblBacteria" id="ABB31792">
        <property type="protein sequence ID" value="ABB31792"/>
        <property type="gene ID" value="Gmet_1558"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1558"/>
    <dbReference type="eggNOG" id="COG0031">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021018_1_0_7"/>
    <dbReference type="OMA" id="RTPVFKF"/>
    <dbReference type="OrthoDB" id="1033353at2"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00200"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005856">
        <property type="entry name" value="Cys_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005859">
        <property type="entry name" value="CysK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="PLP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="Trypto_synt_PLP_dependent"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="SSF53686"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01139">
        <property type="entry name" value="cysK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01136">
        <property type="entry name" value="cysKM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 9 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PALP" evidence="12">
        <location>
            <begin position="9"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="9">
        <location>
            <begin position="179"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="10">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605856-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="309" mass="33142" checksum="1499D47E2F8A237B" modified="2005-11-22" version="1">MAQIYENLTDLIGKTPLLRLRKVAAGIEADIVAKLESFNPGGSVKDRIGVSMIRDAEGRGLINKDTVIIEPTSGNTGIALAFVCAARGYRLVLTMPDTMSVERRNLLKAYGAELVLTRGAEGMKGAINKAEELAADIPNSFIPQQFRNPANPHIHRFTTAEEIWTDTDGKVDVFVAGVGTGGTVTGVGEVLKKRNPGVKIIAVEPFDSPVLSGGHPAPHKIQGIGAGFVPEVLNREAIDEIFTVRNEEALETARRLAREEGLLVGISAGAAAFAALEVARRPENKGKRIVVVLPDTGERYLSTVLFQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VQ3</accession>
    <name>Q39VQ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1437</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511631.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1437"/>
    <dbReference type="EnsemblBacteria" id="ABB31671">
        <property type="protein sequence ID" value="ABB31671"/>
        <property type="gene ID" value="Gmet_1437"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1437"/>
    <dbReference type="eggNOG" id="ENOG5033PN6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1473176_0_0_7"/>
    <dbReference type="OMA" id="GDMLYFA"/>
    <dbReference type="OrthoDB" id="1741873at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="189" mass="19895" checksum="282F89D31F058C8F" modified="2005-11-22" version="1">MIPRVPSPATMLSVLKLFLIPVGGGIPAGVMLAQTKGVAWPFTTLLYLASDIILALAFEPVLRLLAFICGKVSFLSRIGAVMKAATARSVSHFSGTGAGPIALIMIAFGVDPMTGRASALAAGHGIIAGWAFAIAGDMIYFAVIAISTLRLNSYIHDPNITMLIILVAMFCVPALVRFIRSKLVILQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VT2</accession>
    <name>Q39VT2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1408</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511659.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1408"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31642">
        <property type="protein sequence ID" value="ABB31642"/>
        <property type="gene ID" value="Gmet_1408"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1408"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_791701_0_0_7"/>
    <dbReference type="OMA" id="MIIAHAN"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="354" mass="39761" checksum="EC69088F382ADEF2" modified="2005-11-22" version="1">MAKLCHKPLHILFFRHSLLGRGGDKMVVCQANALARRGHQVTIRTATLATPFSLDDRIEINLTGSSSVAATLMDLFKGRFSFDLLIVDIIPLAVLAGIRFGRTKVIYYVQDWDVSYYRSLAFRSLIRLLYFVERSFLRIPVIVVSEHLLGKIGRTGIGATYVVENGIDLTLFNSKGRLHPAFAPGHIPTFLLFIRNDWRKGSDLALKVVKKLADRYPHAFGVVAVGNRPAIRPSQIDWIDKGFMDERQIADLMKQCDLFLYPSRHEGFGLMALEAFACGCLVVTTTAVGFAHDIENSLVAEVDDEQGLYSRLCCLLEKQIEIAPLVKKAEEFASEHPLELCMDRFCSVIEELNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VX5</accession>
    <name>Q39VX5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513143.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1365"/>
    <dbReference type="EnsemblBacteria" id="ABB31599">
        <property type="protein sequence ID" value="ABB31599"/>
        <property type="gene ID" value="Gmet_1365"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1365"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_10_7"/>
    <dbReference type="OMA" id="ISHHENW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD-GYP" evidence="1">
        <location>
            <begin position="188"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="388" mass="42869" checksum="EB2720502DC76EF3" modified="2005-11-22" version="1">MTLELCNTSLQQTQELLRLVNATLRNLSNRKFTDKELHVEALGRVLGGSGRRGPLSIFILLNGKAGASRGRVFHLSAGEIVEGSEEILIDPASVYAPERLTDEVIISNWCDTCETVEEYQAYFHPTVKEYMGKLLTNFICCHIGGDAGGALLAFNYPGEATEYDAMVLQSLAVVIGSLTTLSNSVRETEKAFIYTIESLARACEAAEEGTGEHIVRVNRYAGALAANMGLPVDLVEVISYSAQMHDVGKIRVPNEILLKPAPLNEDELRIMRLHPAYGEKILGDSPRLQIAREIAISHHENWDGSGYPHGLRGEDIPLSGRIVKLADVYDALRSRRSYKEPLSHEEALSVFTVGDRRIDPGRHFDPAVMATFFAIEHIFARIYKSMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W20</accession>
    <name>Q39W20_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Heptapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1319</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514706.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1319"/>
    <dbReference type="EnsemblBacteria" id="ABB31554">
        <property type="protein sequence ID" value="ABB31554"/>
        <property type="gene ID" value="Gmet_1319"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1319"/>
    <dbReference type="eggNOG" id="ENOG50338NA">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158530_0_0_7"/>
    <dbReference type="OMA" id="NESFQHK"/>
    <dbReference type="OrthoDB" id="2077542at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="91" mass="10488" checksum="528C6EE627C5F7AD" modified="2005-11-22" version="1">MALDEIDLKKIEELFKHQIGILNESFQHKLDIVVEGHQMLNEKADRLEGRMDRLEGRMDRLEVKLDAVATDLAAHRADTEAHHGVYRVKEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W48</accession>
    <name>METK_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">S-adenosylmethionine synthase</fullName>
            <shortName evidence="1">AdoMet synthase</shortName>
            <ecNumber evidence="1">2.5.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">MAT</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Methionine adenosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">metK</name>
        <name type="ordered locus">Gmet_1290</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-methionine = diphosphate + phosphate + S-adenosyl-L-methionine</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 divalent ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="1">Binds 1 potassium ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer; dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AdoMet synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512076.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W48"/>
    <dbReference type="SMR" id="Q39W48"/>
    <dbReference type="STRING" id="269799.Gmet_1290"/>
    <dbReference type="EnsemblBacteria" id="ABB31526">
        <property type="protein sequence ID" value="ABB31526"/>
        <property type="gene ID" value="Gmet_1290"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1290"/>
    <dbReference type="eggNOG" id="COG0192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041802_1_1_7"/>
    <dbReference type="OMA" id="MPYLRPD"/>
    <dbReference type="OrthoDB" id="1024388at2"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="PTHR11964"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="SSF55973"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000240997" description="S-adenosylmethionine synthase">
        <location>
            <begin position="1"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Flexible loop" evidence="1">
        <location>
            <begin position="101"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="234"/>
            <end position="235"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="1">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <note>ligand shared between two neighboring subunits</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00086"/>
        </source>
    </evidence>
    <sequence length="389" mass="42541" checksum="13F68C6282843BAB" modified="2005-11-22" version="1">MEMKDYIFTSESVSEGHPDKVADQVSDSILDAILAQDPRARVACETLVTTGMAVIAGEITTSAVVDYPKVVRETIREIGYNDSAMGFDWETCAVLVSIDKQSPDISQGVTEGEGMFKEQGAGDQGLMFGYACTETPELMPMSITYAHKLTQKLAEVRKNGVLDFLRPDSKSQVSVEYVDDKPVRVDTVVISSQHTPEVSYEAIKEGIIEEVVKKIIPAHLMDERTRMLINPTGRFVVGGPMGDCGLTGRKIIVDSYGGHGAHGGGAFSGKDPSKVDRSAAYMGRYVAKNLVAAGLCEKCEVQVAYAIGVAEPVSVMVDTAGTGKISSKRIAEIVREVFDLRPRAIIEQLDLLRPIYRKTAAYGHFGRELPEFTWERTDKVYMIRQKAGI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W52</accession>
    <name>Y1286_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nucleotide-binding protein Gmet_1286</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_1286</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Displays ATPase and GTPase activities.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RapZ-like family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512080.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W52"/>
    <dbReference type="SMR" id="Q39W52"/>
    <dbReference type="STRING" id="269799.Gmet_1286"/>
    <dbReference type="EnsemblBacteria" id="ABB31522">
        <property type="protein sequence ID" value="ABB31522"/>
        <property type="gene ID" value="Gmet_1286"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1286"/>
    <dbReference type="eggNOG" id="COG1660">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059558_0_0_7"/>
    <dbReference type="OMA" id="TVMSFGF"/>
    <dbReference type="OrthoDB" id="1603998at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00636">
        <property type="entry name" value="RapZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005337">
        <property type="entry name" value="RapZ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30448">
        <property type="entry name" value="PTHR30448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03668">
        <property type="entry name" value="ATP_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005052">
        <property type="entry name" value="P-loopkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000258965" description="Nucleotide-binding protein Gmet_1286">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="8"/>
            <end position="15"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00636"/>
        </source>
    </evidence>
    <sequence length="285" mass="32175" checksum="E6DC8FCAF55499C4" modified="2005-11-22" version="1">MRVLVISGLSGSGKSTAVRVLEDEGFFCIDNLPVQLFPTIIDLVNKAQETVPGVALVMDIRGRDFLKGFEKIFQEIDDAGHTIEIIFFDATDEVLIRRFSETRRRHPALESGSVPEGIRYEREQLSGLRRLATLVIDTSELNVHQLKEMVLARVKGEAGARRMTIHLQSFGYRYGIPLESDLVMDVRFLSNPHFVPELKPLSGLDPGVRNFVLEKPETTQFLARFEGLLEYLLPAYQREGKSYLTISIGCTGGRHRSVALVEELRRFFDRAGIAVKVSHRDMEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WB7</accession>
    <name>Q39WB7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512149.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1220"/>
    <dbReference type="EnsemblBacteria" id="ABB31457">
        <property type="protein sequence ID" value="ABB31457"/>
        <property type="gene ID" value="Gmet_1220"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1220"/>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_8_7"/>
    <dbReference type="OMA" id="DHPQVMV"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="16"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="143" mass="16122" checksum="57D0BEE3296D70B5" modified="2005-11-22" version="1">MNPTQGHRTATIRPTRILVVDDDRDVLFFMKLALETEGIDVTCAERGEDALGLLAERSYGVLLTDQNMPGMDGFELAQHARRLQPELIIFMGTGHLYPGIEERATAVGIREVFGKPFNFQRLFEQLLEALSHNKGHQSTRRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WD8</accession>
    <name>Q39WD8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31436.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512171.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1199"/>
    <dbReference type="EnsemblBacteria" id="ABB31436">
        <property type="protein sequence ID" value="ABB31436"/>
        <property type="gene ID" value="Gmet_1199"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1199"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024625_0_2_7"/>
    <dbReference type="OMA" id="FERRAIN"/>
    <dbReference type="OrthoDB" id="1637190at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021728">
        <property type="entry name" value="DUF3300"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40269">
        <property type="entry name" value="PTHR40269"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11737">
        <property type="entry name" value="DUF3300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223210" evidence="2">
        <location>
            <begin position="28"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31436.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="451" mass="50792" checksum="617378473F60AB3E" modified="2012-10-31" version="2">MKATIMTILKVACIVIVMLAMPVGTMAQEGEADQAAKFSKQELTQMLAPIALYPDSLIAQVLMASTYPLELVEAERWRRDNMGLKGTELDNALQNKPWDPSVKSLCHFPDVLFALSDKLDQTRKLGDAFLSQEDDVMASIQELRQKAEQQGNLKTTSQQKVVEDQGEIQIEPVDPEVIYVPVYDPSYIYGPWWYPDYPPYYWYYPTSYPFGLSYIAFGPPFYFSFNIFSWAWCDWRSHRIHVDFDRTRRFNRFNTSRDLGGSVWRHNPVHRRGVAYRDIRTGERFGLRPTRVSPAGPETRGYPVRGQVRPGLRGTQAPAGRVPEQRERAVVPQREQGPAVRQAPVERREGTTVTPRIQAPREQVQRPAGRDTPFRGVGEGTFERRAINRGEMSIRSGTPPMGRSRGGFGGEIRQPSGGFRGGEIRQPAGGGFRGGEIRQPSGGGSRGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WI3</accession>
    <name>Q39WI3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transporter, DUF21, CBS domain pair and CorC_HlyC domain-containing, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ordered locus">Gmet_1153</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513418.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1153"/>
    <dbReference type="EnsemblBacteria" id="ABB31391">
        <property type="protein sequence ID" value="ABB31391"/>
        <property type="gene ID" value="Gmet_1153"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1153"/>
    <dbReference type="eggNOG" id="COG1253">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015237_4_1_7"/>
    <dbReference type="OMA" id="FMIMTYL"/>
    <dbReference type="OrthoDB" id="1155802at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005170">
        <property type="entry name" value="Transptr-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03471">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="DUF21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01091">
        <property type="entry name" value="CorC_HlyC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="SSF56176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="11">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="223"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="10">
        <location>
            <begin position="287"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB31391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="447" mass="48919" checksum="0DA7DBAF1E8CA1F5" modified="2005-11-22" version="1">MESVLGELAVIFLLILGNGFFAGSELAIISARKSRIAQLVAAGDPKAKIVEQLQDDPHRFLATVQIGVTLVGSLASAVGGATAVRYLKPLLEGSSIKFFHNAAEPLSIGIVVVLISYFSLIFGELVPKTVGLQYADRMALHVAKPINFMARVTGVVVSFLTLSNRAVLAVLGIKAEGDQAFVTPEEVQHIVAEGHEAGVFSSTEQEFIRNIFDFTHTCVREVMVPRTRVVALDLGLSRDELVNTVLENKYSRYPVYRESIENVTGFIHGKDLLGGIVTDPAFDIKSIIRPPFYVPEGKKVNELLKEMQRKRIHMALVVDEYGGISGLATTEDLLEELVGEIEDEHDIGEPGSIQRLPDGSLLVDALVSISDLAEHLEIKLGDDIPYDTLAGLILDRLGRFPEKGERVEWDRFTLICEEVKKTAVVKVRIVETVPSDSGHEEDGDVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WI6</accession>
    <name>Q39WI6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thiol:disulfide interchange protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the thioredoxin family. DsbC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513415.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1150"/>
    <dbReference type="EnsemblBacteria" id="ABB31388">
        <property type="protein sequence ID" value="ABB31388"/>
        <property type="gene ID" value="Gmet_1150"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1150"/>
    <dbReference type="eggNOG" id="COG1651">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083593_1_0_7"/>
    <dbReference type="OMA" id="KMEAIWC"/>
    <dbReference type="OrthoDB" id="1678187at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03020">
        <property type="entry name" value="DsbA_DsbC_DsbG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033954">
        <property type="entry name" value="DiS-bond_Isoase_DsbC/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018950">
        <property type="entry name" value="DiS-bond_isomerase_DsbC/G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009094">
        <property type="entry name" value="DiS-bond_isomerase_DsbC/G_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012336">
        <property type="entry name" value="Thioredoxin-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10411">
        <property type="entry name" value="DsbC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13098">
        <property type="entry name" value="Thioredoxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54423">
        <property type="entry name" value="SSF54423"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 5" id="KW-0574">Periplasm</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5010007999" description="Thiol:disulfide interchange protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="DsbC_N" evidence="6">
        <location>
            <begin position="37"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin-like_fold" evidence="7">
        <location>
            <begin position="120"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="267" mass="29604" checksum="EDADDCABBD25CD0F" modified="2005-11-22" version="1">MRLQLLRFVGALSLTACLAAPTAFAAPKEQAKGETPEAAVKRLFPKLPATAVKKTDIDGFYEVVADGNILYVNVKTGHVFVGDIFTREGKNLTAEARTRLTAERYKLITEADKEKAVKVGNGKHVVIEITDPDCPFCRKMHEYWGNRPDVTRYVFFLPLAMHKDAEKKARYILAADNKEQALWEVYSGELDNNREKLNKPYDDKGLLSAHKAVVAKLGIQSTPAFWVDGTFVNGANIPLIEKIIGKCNLRQGTAPGEPKVCDDEQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WW0</accession>
    <name>Q39WW0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Respiratory nitrate reductase, cytochrome b gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">narI-2</name>
        <name evidence="15" type="ordered locus">Gmet_1022</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31264.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365763.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1022"/>
    <dbReference type="EnsemblBacteria" id="ABB31264">
        <property type="protein sequence ID" value="ABB31264"/>
        <property type="gene ID" value="Gmet_1022"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1022"/>
    <dbReference type="eggNOG" id="COG2181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092378_0_0_7"/>
    <dbReference type="OMA" id="LFHWGIW"/>
    <dbReference type="OrthoDB" id="1873056at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009325">
        <property type="term" value="C:nitrate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008940">
        <property type="term" value="F:nitrate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023234">
        <property type="entry name" value="NarG-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003816">
        <property type="entry name" value="Nitrate_red_gam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02665">
        <property type="entry name" value="Nitrate_red_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00351">
        <property type="entry name" value="narI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Nitrate_red_gam" evidence="14">
        <location>
            <begin position="4"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB31264.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="229" mass="25865" checksum="C56B4B7C6BBF237D" modified="2012-10-31" version="2">MTDYLFFGVFPYVALVVAVGGGVYRYAKERFSFSSLSSQFLENRALFWGSVAWHYGIVLVLLAHLAALLLPASWGRLLGDPLRLAVLEVTGLALGLFTLAGIVVLLFRRIASPKAWAVVTVMDLFLLAVLVLQVGTGLYNAFVYRWGSLWYLSLAVPWLHSLACLNPDIKYIVPLPLPVKVHLFNAFVIFVLFPVTRLVHIVSIPVSYLWRPWQIAVWNKPPRWMIPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X12</accession>
    <name>Q39X12_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix transcriptional regulator, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514364.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0970"/>
    <dbReference type="EnsemblBacteria" id="ABB31212">
        <property type="protein sequence ID" value="ABB31212"/>
        <property type="gene ID" value="Gmet_0970"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0970"/>
    <dbReference type="eggNOG" id="COG1476">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_48_0_7"/>
    <dbReference type="OMA" id="GEDCRME"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="7"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="66" mass="7639" checksum="D1A01157AF45462F" modified="2005-11-22" version="1">MKFKNNVRKIREERLMSKAELARLAGVSPATIDRIEHGEECRMETKRKIILAFGFSLSEKEAVFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X27</accession>
    <name>Q39X27_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Response regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514438.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0955"/>
    <dbReference type="EnsemblBacteria" id="ABB31197">
        <property type="protein sequence ID" value="ABB31197"/>
        <property type="gene ID" value="Gmet_0955"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0955"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039039_0_0_7"/>
    <dbReference type="OMA" id="VWEVVPE"/>
    <dbReference type="OrthoDB" id="1729688at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="177"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="439" mass="45387" checksum="1ED3A31BB4021AAA" modified="2005-11-22" version="1">MGNRILLADDSITIQKVVGIIFANEDCDLTVVDNGDSAVEKAREVTPDVMLVDALMPGKSGYEVCTAIRKDPALGTVPILLMTGAFEPFDEEKARQCGADDFISKPFESQQLIDKVKTLLDLGKSRAGAPSVAAAAPTMTAVTPPAAPTVAEAAESIASVAPVAAGPVESFAIEFDEPASSEPQPAVTPPPTPEPTAAKVTVPEPQPFVFAVEEASPADDLWGAFELEDEVVGDEPVKSSQAAADGASAAVDEVSPFGLEQTPDVFGAGTGPAAESVDFGFASASDEFGFAVAAETPAPSASVEPAPFSAPPMDESFVFGEESAESVVEPYGSISETPVSGAFDPGIEPFEMPLKTEFTPAAGVSSFAPEEKPVPSSASFTAAPAVEGGGGTITLTEEQLAAAISRISREVIERIAWEVVPDLAETLIKEEIRRIKEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X51</accession>
    <name>Q39X51_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine protease, subtilase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0931</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513961.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0931"/>
    <dbReference type="EnsemblBacteria" id="ABB31173">
        <property type="protein sequence ID" value="ABB31173"/>
        <property type="gene ID" value="Gmet_0931"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0931"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_15_7_7"/>
    <dbReference type="OMA" id="IEWCIDY"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07477">
        <property type="entry name" value="Peptidases_S8_Subtilisin_subset"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034202">
        <property type="entry name" value="Subtilisin_Carlsberg-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223403" evidence="6">
        <location>
            <begin position="25"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="126"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="500" mass="52924" checksum="C6B1777C09EE6AE1" modified="2005-11-22" version="1">MNILRTLLVAVMGAMLCLPLDSFAATKKVIVGFTRAPKDHEKNLVYGARGRIHRTHQHIRAISAELPEEEIARLKQDPSVAYVVDNIKFTLIRPAEPLSVPSPEYVDSWGVLRIGSNVAASRGYKGAGIKVAIVDSGIDYNHPDLKDNYRGGYNFVNNTADPFDDDAQSHGTHVAGIIAARDNGTGVVGVAPEASLYAVKVFSATAGGDMDTVVAGIEWAIDNKMDVINLSIGYSGDIYSIYPDIFKPLKDVCDRAYQAGIVLVAATGNDNRETISVPAAFDSVIAVAATDQNDQRAVFNTVAASSYGAKVELAAPGTYIKSTVSGGGYALLSGTSQASPHVAGAAAVLLSSGIADANGNGSRADEVRARLDATAKDLGDPGRDKYFGWGLVDLSASTDQTYKLHIEKKKGMPKLSTQSITLDKGSYSLQVRNNGLERLAVKSVVGSCKEFERVFATGFTSPLEELNASVTLDGSQTTLVFTPSGDIGSSADITITKLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X58</accession>
    <name>Q39X58_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Glucose-1-phosphate thymidylyltransferase</fullName>
            <ecNumber evidence="4 5">2.7.7.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rmlA</name>
        <name evidence="7" type="ordered locus">Gmet_0924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:15225"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37568"/>
            <dbReference type="ChEBI" id="CHEBI:57477"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.7.7.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 5">Belongs to the glucose-1-phosphate thymidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.24" evidence="4 5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513954.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0924"/>
    <dbReference type="EnsemblBacteria" id="ABB31166">
        <property type="protein sequence ID" value="ABB31166"/>
        <property type="gene ID" value="Gmet_0924"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0924"/>
    <dbReference type="eggNOG" id="COG1209">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029499_9_0_7"/>
    <dbReference type="OMA" id="FTWLDTG"/>
    <dbReference type="OrthoDB" id="1004719at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008879">
        <property type="term" value="F:glucose-1-phosphate thymidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045226">
        <property type="term" value="P:extracellular polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02538">
        <property type="entry name" value="G1P_TT_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005907">
        <property type="entry name" value="G1P_thy_trans_s"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43532">
        <property type="entry name" value="PTHR43532"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01207">
        <property type="entry name" value="rmlA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTP_transferase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="302" mass="33034" checksum="1469C387E0C08425" modified="2005-11-22" version="1">MAIKKGIILAGGAGSRLYPLTLVASKQLQPVYDKPMIYYPLATLMMAGISDILIISTPHDTPRFQSLLGDGSRWGIRLTYKVQPEPKGIAQAFLVGEEFIAGDPVCLILGDNIFYGKMGLDRAIRDFAGGALVFGYYVNDPERYGVVQFDGSGKAIGIEEKPAAPKSNYAVPGLYLYDGKVSEIARNLAPSARGELEITDVNLEYLRRGELMVEKLGRGIAWLDTGTHQSLLEASHFIGTLEARQGLKIACLEEIALRMGYIDCRKMAEVIAATPNSSYREYLVRVHNETNLCGGHDDAKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X88</accession>
    <name>Q39X88_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0894</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513041.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0894"/>
    <dbReference type="EnsemblBacteria" id="ABB31136">
        <property type="protein sequence ID" value="ABB31136"/>
        <property type="gene ID" value="Gmet_0894"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0894"/>
    <dbReference type="HOGENOM" id="CLU_2450416_0_0_7"/>
    <dbReference type="OMA" id="KKHWEEQ"/>
    <dbReference type="OrthoDB" id="2008824at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="97" mass="11150" checksum="C41286365FFF7578" modified="2005-11-22" version="1">MDDKEKQEISLIGRILSMEALLILMGIASLGYGIARAQVMSIFWGVMILVGAVVLSFVRKKDWKKHWEEMEGAQRRYEARMKAQEEQPKEHDDAGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X91</accession>
    <name>Q39X91_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA topoisomerase 1</fullName>
            <ecNumber evidence="10">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10 12" type="primary">topA</name>
        <name evidence="12" type="ordered locus">Gmet_0891</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513038.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0891"/>
    <dbReference type="EnsemblBacteria" id="ABB31133">
        <property type="protein sequence ID" value="ABB31133"/>
        <property type="gene ID" value="Gmet_0891"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0891"/>
    <dbReference type="eggNOG" id="COG0550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002929_4_3_7"/>
    <dbReference type="OMA" id="PECKYTR"/>
    <dbReference type="OrthoDB" id="223233at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03363">
        <property type="entry name" value="TOPRIM_TopoIA_TopoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00952">
        <property type="entry name" value="Topoisom_1_prok"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013498">
        <property type="entry name" value="Topo_IA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005733">
        <property type="entry name" value="TopoI_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028612">
        <property type="entry name" value="Topoisom_1_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034149">
        <property type="entry name" value="TOPRIM_TopoI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42785">
        <property type="entry name" value="PTHR42785"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01396">
        <property type="entry name" value="zf-C4_Topoisom"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="SSF56712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01051">
        <property type="entry name" value="topA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPOISOMERASE_I_PROK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Toprim" evidence="11">
        <location>
            <begin position="3"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with DNA" evidence="10">
        <location>
            <begin position="167"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="10">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB31133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="758" mass="84932" checksum="B154BAC1A7A190CE" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XB4</accession>
    <name>Q39XB4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integration host factor, beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">ihfB-2</name>
        <name evidence="3" type="ordered locus">Gmet_0868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513014.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0868"/>
    <dbReference type="EnsemblBacteria" id="ABB31110">
        <property type="protein sequence ID" value="ABB31110"/>
        <property type="gene ID" value="Gmet_0868"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0868"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_2_3_7"/>
    <dbReference type="OMA" id="IAEANPH"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="95" mass="10884" checksum="30EFFE45FF50077B" modified="2005-11-22" version="1">MTKSELVEQLAEKNTWLTRKDSEMIVNLVFDSISDALKRGEKVEIRGFGSFTVRERGAREARNPKSGDVVKIPAKKTPFFKTGKELRERVNTKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XC6</accession>
    <name>Q39XC6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513001.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0856"/>
    <dbReference type="EnsemblBacteria" id="ABB31098">
        <property type="protein sequence ID" value="ABB31098"/>
        <property type="gene ID" value="Gmet_0856"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0856"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094894_0_0_7"/>
    <dbReference type="OMA" id="WIQLGND"/>
    <dbReference type="OrthoDB" id="1382732at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="67"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="101"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="198" mass="21847" checksum="BB7FA06588D3AE75" modified="2005-11-22" version="1">MNKETVLYVVIALLVGILGTVLVVGVVNKQKPAPATAGIPAGGGSPVDYQQRIAEAEKVVANDPKNLQAWIQLGNDYFDTDQAQKAINAYGKALELDPTNANVLTDQGIMFKRVGWFDKAIANFEKAQQLDPKHLQSLYNLGVVYMSDLKQPAKAVKYWERYLELDPMGPNSQQIRTMLEEAKGMAQTPSPQGQLFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XI9</accession>
    <name>Q39XI9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0793</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513538.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0793"/>
    <dbReference type="EnsemblBacteria" id="ABB31035">
        <property type="protein sequence ID" value="ABB31035"/>
        <property type="gene ID" value="Gmet_0793"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0793"/>
    <dbReference type="eggNOG" id="COG4422">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1105896_0_0_7"/>
    <dbReference type="OrthoDB" id="979208at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011101">
        <property type="entry name" value="DUF5131"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07505">
        <property type="entry name" value="DUF5131"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="251" mass="28396" checksum="CECE61F24173C23C" modified="2005-11-22" version="1">MFNRLRQGIFWDDAWEVLVRRDTVDREILWRPFGEKEGKVWSVGGDPFHPSLPVEQLDAMLSVVASSPQHLFITVTDYPEHSFQRLYATSPDSPYRLLEEDDTLNNLWFLVRIRDQEEADLRVPATIALKNCWVADGVRWPMVGILAEPLRGGLNLRQVNSLCLAGFGAIDWVVCGGAGDGDVPHHADWARDLRDQAEERGIPFLYTGSGGLLDGRTWDEIPPFRGEPNHLHVFDHCRANRQDGSIRSVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XK7</accession>
    <name>Q39XK7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidoglycan-binding outer membrane protein, OMP_b-brl, OmpA and OmpA domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Gmet_0775</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell outer membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513520.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0775"/>
    <dbReference type="EnsemblBacteria" id="ABB31017">
        <property type="protein sequence ID" value="ABB31017"/>
        <property type="gene ID" value="Gmet_0775"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0775"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031536_2_0_7"/>
    <dbReference type="OMA" id="DEGRQAN"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027385">
        <property type="entry name" value="OMP_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006690">
        <property type="entry name" value="OMPA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13505">
        <property type="entry name" value="OMP_b-brl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01068">
        <property type="entry name" value="OMPA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0626">Porin</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223404" evidence="11">
        <location>
            <begin position="23"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="12">
        <location>
            <begin position="210"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="12">
        <location>
            <begin position="336"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="457" mass="50138" checksum="E3C6F12383AD3C01" modified="2005-11-22" version="1">MKRLLAAGCALFALAFATTAMAEVKPGSFAITPYVGGYTFDGEQHIKTGPTFGIRGGYNFTKNCGLEGVFGYTPTEQTKRESDVDAITYRLEGLYHFMPEKDLVPFLAVGGGGITIDSEGAGVKSRTDGIVTAGGGLKYFINEALAVRTDGRYILDLSRTLSNWEYTVGLSFLFGGEKKAVAPVAPAAAPAEATPAPEAPPAVMAAEPRPGLMKYCTDLKIEFDIDKADIRPQYKDEVKRVADYMKQYPNTTAVIEGYTDDVGSDDYNMKLSQRRAEAVVNSLVDDFGIDRSRLSAKGYGKTQPLTSNATEAGKQKNRRIQAVIDCTLEDPKVIAKLPDRLCVSLNIQFDTDKYTIKPQYHDEIAKVGEFMKQNPTTTAVIEGHTDRVGSYDYNMKLSLRRAESVVTYLADKFGIERSRLSAKGYGYTRPIGYNSDPKGRAMNRRINAIIDCVLQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XR5</accession>
    <name>Q39XR5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0717</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514622.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0717"/>
    <dbReference type="EnsemblBacteria" id="ABB30959">
        <property type="protein sequence ID" value="ABB30959"/>
        <property type="gene ID" value="Gmet_0717"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0717"/>
    <dbReference type="HOGENOM" id="CLU_1097366_0_0_7"/>
    <dbReference type="OMA" id="SEDEQFR"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="253" mass="26931" checksum="DB29C33D4A33A8DA" modified="2005-11-22" version="1">MIRPRFFTMDTIQRFIIASLALHGVILAAVSSYDSMTARRHRVQTANWVVDVITDIRSEQAGPDNSAAVQDQEVLPSQDEPQSQPPPESAAPAELPPDAPPAPVPPASQADPSVGSTGTGGQASAPVNTVALTGAFLSQGFRNTMNAQAIVAQLGNYRRVSGLALKGMVSQALPAEERQRPDEVRGTVLVTFQDGAVASLSVESEDEQFRSLLRDRIDWSLLPAPRQFSLPISRVACTVSVSNGKIRVGVGPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XW1</accession>
    <name>Q39XW1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrogenase molybdenum-iron cofactor biosynthesis protein NifX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">nifX</name>
        <name evidence="4" type="ordered locus">Gmet_0671</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NifX/NifY family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514062.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0671"/>
    <dbReference type="EnsemblBacteria" id="ABB30913">
        <property type="protein sequence ID" value="ABB30913"/>
        <property type="gene ID" value="Gmet_0671"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0671"/>
    <dbReference type="eggNOG" id="COG1433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104194_3_0_7"/>
    <dbReference type="OMA" id="MQIGGPA"/>
    <dbReference type="OrthoDB" id="1995095at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051540">
        <property type="term" value="F:metal cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009399">
        <property type="term" value="P:nitrogen fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00853">
        <property type="entry name" value="NifX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003731">
        <property type="entry name" value="Di-Nase_FeMo-co_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036105">
        <property type="entry name" value="DiNase_FeMo-co_biosyn_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013480">
        <property type="entry name" value="NifX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034169">
        <property type="entry name" value="NifX-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02579">
        <property type="entry name" value="Nitro_FeMo-Co"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53146">
        <property type="entry name" value="SSF53146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02663">
        <property type="entry name" value="nifX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0535">Nitrogen fixation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitro_FeMo-Co" evidence="3">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="127" mass="13838" checksum="22331BA31457955C" modified="2005-11-22" version="1">MKVAFTSTTGEMIDEHFGMAKNFHIWEIGPEASSFLETVTIGAHGDDEEDKIAARAAALRECAIVYTMAIGGPAAAKLVALKIHPMKTNSPVSLPETVNRLQEVLKGNPPPWLRKAMNKGEETSFEE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-09-11" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XY3</accession>
    <name>RL36_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpmJ</name>
        <name type="ordered locus">Gmet_0649</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL36 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XY3"/>
    <dbReference type="SMR" id="Q39XY3"/>
    <dbReference type="STRING" id="269799.Gmet_0649"/>
    <dbReference type="EnsemblBacteria" id="ABB30891">
        <property type="protein sequence ID" value="ABB30891"/>
        <property type="gene ID" value="Gmet_0649"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0649"/>
    <dbReference type="eggNOG" id="COG0257">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_135723_6_2_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00251">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000473">
        <property type="entry name" value="Ribosomal_L36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035977">
        <property type="entry name" value="Ribosomal_L36_sp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42888">
        <property type="entry name" value="PTHR42888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00444">
        <property type="entry name" value="Ribosomal_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57840">
        <property type="entry name" value="SSF57840"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01022">
        <property type="entry name" value="rpmJ_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00828">
        <property type="entry name" value="RIBOSOMAL_L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <feature type="chain" id="PRO_0000302211" description="50S ribosomal protein L36">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00251"/>
        </source>
    </evidence>
    <sequence length="37" mass="4280" checksum="AE701F63CE902825" modified="2005-11-22" version="1">MKVRASVKKICDKCKIIKRKGIVRVICETPKHTQRQG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y16</accession>
    <name>RL1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplA</name>
        <name type="ordered locus">Gmet_0616</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514632.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y16"/>
    <dbReference type="SMR" id="Q39Y16"/>
    <dbReference type="STRING" id="269799.Gmet_0616"/>
    <dbReference type="EnsemblBacteria" id="ABB30858">
        <property type="protein sequence ID" value="ABB30858"/>
        <property type="gene ID" value="Gmet_0616"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0616"/>
    <dbReference type="eggNOG" id="COG0081">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062853_0_0_7"/>
    <dbReference type="OMA" id="GWTDVDV"/>
    <dbReference type="OrthoDB" id="1671455at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01318_B">
        <property type="entry name" value="Ribosomal_L1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005878">
        <property type="entry name" value="Ribosom_L1_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_L1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_L1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_L1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_L1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023673">
        <property type="entry name" value="Ribosomal_L1_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="SSF56808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01169">
        <property type="entry name" value="rplA_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01199">
        <property type="entry name" value="RIBOSOMAL_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0678">Repressor</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0810">Translation regulation</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000230608" description="50S ribosomal protein L1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01318"/>
        </source>
    </evidence>
    <sequence length="234" mass="24995" checksum="D00503577D7A26F6" modified="2005-11-22" version="1">MPKTAKKHREALAKIDRSRTYPLVEGIESVKSVAYAKFDETVEVAVRLGVDPRHADQMVRGAVVLPNGLGKDVRVLVFAKGEKEKEARDAGADHVGAEDLVAKIQEGWFDFDTAIATPDMMGVVGKIGKLLGPRGLMPNPKVGTVTFDVGRAVKESKAGKVEFRVEKAGIVHAPVGKASFDADKLKENLLALVEALVKAKPSAAKGTYIKKISLSSTMGPGLNLDIADVQSKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y20</accession>
    <name>Q39Y20_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">50S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5 6" type="primary">rpmG</name>
        <name evidence="6" type="ordered locus">Gmet_0612</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514628.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0612"/>
    <dbReference type="EnsemblBacteria" id="ABB30854">
        <property type="protein sequence ID" value="ABB30854"/>
        <property type="gene ID" value="Gmet_0612"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0612"/>
    <dbReference type="eggNOG" id="COG0267">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190949_0_2_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00294">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="L33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_L33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018264">
        <property type="entry name" value="Ribosomal_L33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43168">
        <property type="entry name" value="PTHR43168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="SSF57829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00582">
        <property type="entry name" value="RIBOSOMAL_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="49" mass="5923" checksum="2312055BB02E3308" modified="2005-11-22" version="1">MRDIITLACAECKQRNYTTTKNKKTTPQKLEFKKYCRFCRTHTVHKETK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y36</accession>
    <name>Q39Y36_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-protein synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0595</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512293.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0595"/>
    <dbReference type="EnsemblBacteria" id="ABB30838">
        <property type="protein sequence ID" value="ABB30838"/>
        <property type="gene ID" value="Gmet_0595"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0595"/>
    <dbReference type="eggNOG" id="COG1541">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043257_1_0_7"/>
    <dbReference type="OMA" id="METGGMK"/>
    <dbReference type="OrthoDB" id="839891at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047474">
        <property type="term" value="F:long-chain fatty acid luciferin component ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008218">
        <property type="term" value="P:bioluminescence"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007534">
        <property type="entry name" value="LuxE"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04443">
        <property type="entry name" value="LuxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LuxE" evidence="1">
        <location>
            <begin position="25"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="415" mass="46453" checksum="70CAE5360A2AC820" modified="2005-11-22" version="1">MSDDRRRELFETIRDYITDSRGEDRFESLALEVFRFQYGANEAYRAYCDGKGINPAGIGRWEDIPAYPSDAFKKNLVISFPYEKTVMANITGGTTDPDLRGIIFRDEYGRELVLAANRKVMGDYVFPEGERMPILVLAPSPETAPSMGMAIGMAETIRSFGTDQSGFFITRRGFLIREFMDRLRELVVADRPVALIGSTSAFIYFFNACRKNGLRFALPAGSRIVDGGGYRGRFGDCGRDEYYERCRDTFGVDPAYCLNVLGMAESATNSADSSLKDLRTGLDRERIKPDLPWCRVVAMDIETCSRVLPPGEVGLLRHYDLANLPTVLGVQTDNLGFRTEDGFEIIGRAQVVDGKVSPMPSEKPVGPMGEKKIFSFLDLYMKFSIGRYVAKIKKDDPLCPCGEAIEEMIVREGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y40</accession>
    <name>Q39Y40_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Beta_helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512289.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0591"/>
    <dbReference type="EnsemblBacteria" id="ABB30834">
        <property type="protein sequence ID" value="ABB30834"/>
        <property type="gene ID" value="Gmet_0591"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0591"/>
    <dbReference type="eggNOG" id="COG3420">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_410374_0_0_7"/>
    <dbReference type="OMA" id="TGLQAHF"/>
    <dbReference type="OrthoDB" id="1306112at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039448">
        <property type="entry name" value="Beta_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13229">
        <property type="entry name" value="Beta_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="SSF49452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="SSF51126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223447" description="Beta_helix domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Beta_helix" evidence="2">
        <location>
            <begin position="487"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="667" mass="72289" checksum="627E6E55F594E49F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y49</accession>
    <name>Q39Y49_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512280.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0582"/>
    <dbReference type="EnsemblBacteria" id="ABB30825">
        <property type="protein sequence ID" value="ABB30825"/>
        <property type="gene ID" value="Gmet_0582"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0582"/>
    <dbReference type="eggNOG" id="COG0666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_805989_0_0_7"/>
    <dbReference type="OMA" id="ACMQGHE"/>
    <dbReference type="OrthoDB" id="1190323at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="SSF48403"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223430" evidence="2">
        <location>
            <begin position="25"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="155"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="221"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="254"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="344" mass="36543" checksum="AA0B882219452A61" modified="2005-11-22" version="1">MLNKCLLLTGALIAVLTAPLAAPAYEYDQEQTRKLIENMVRDLGGHDGLRANSGKVMRCVHGGTKKVTIVQNGALTTYNGVYSNCRENDSIRDGIYDIALEGNEVTVSSSKRSINGELFDAAMGGDAKAVKRLVKAKADVNYTESIKKSGGGHIDEWTPLMSAVASGSLDSVKQLVTAGAWVNYMNSMAVNALWIAANKGDVAIVKYLLKSGAYVNNRNFEDVTPLMAASMNGHGEVVKALIAARAKLDYVHSGGDTALMFALAGRHTAVARLLLAAGADVNVRNRDGLTALHIAVSEGNLEMVRGLLKRKADVSATMDSGKNALDIARARGNAAIVELLEKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YA6</accession>
    <name>Q39YA6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAP2_like_6 family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512221.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0525"/>
    <dbReference type="EnsemblBacteria" id="ABB30768">
        <property type="protein sequence ID" value="ABB30768"/>
        <property type="gene ID" value="Gmet_0525"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0525"/>
    <dbReference type="eggNOG" id="COG3907">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070327_2_0_7"/>
    <dbReference type="OMA" id="WPGGHAA"/>
    <dbReference type="OrthoDB" id="1928533at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="100"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="256" mass="28097" checksum="D96272EA4D25353E" modified="2005-11-22" version="1">MKTRTTAPLDAPFWLSHGIVPLLLFVFAATACEITHVDLVLADRFYDFTAGTWPARYSWWAQWLIHERGRDLIAAVTSLSFIAWVLSFQVVRLRPFRWAALYLAMAIGIGICLVAVGRGLSGRHCPWSVERYGGPVPYTRLFEGNPPGANNGHCFPAVHAAGGFSLMAIYFALRDRRAKIARAGLATGFALGTIYGYAQMARGAHFFSHMVWSAAICWFSALGLYWIFRPHLAPSESGGAADGSRFAPATHTGETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YF0</accession>
    <name>Q39YF0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cobalt-precorrin-6B C5,C15-methyltransferase and C12-decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cbiET</name>
        <name evidence="7" type="ordered locus">Gmet_0481</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2008-07" db="PDB data bank">
            <title>CRYSTAL STRUCTURE OF Precorrin-6y C5,15-methyltransferase from Geobacter metallireducens.</title>
            <authorList>
                <person name="Patskovsky Y."/>
                <person name="Ramagopal U.A."/>
                <person name="Toro R."/>
                <person name="Dickey M."/>
                <person name="Hu S."/>
                <person name="Maletic M."/>
                <person name="Sauder J.M."/>
                <person name="Burley S.K."/>
                <person name="Almo S.C."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 211-405</scope>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513850.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="3E05">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=211-405"/>
    </dbReference>
    <dbReference type="PDBsum" id="3E05"/>
    <dbReference type="SMR" id="Q39YF0"/>
    <dbReference type="STRING" id="269799.Gmet_0481"/>
    <dbReference type="DNASU" id="3739848"/>
    <dbReference type="EnsemblBacteria" id="ABB30724">
        <property type="protein sequence ID" value="ABB30724"/>
        <property type="gene ID" value="Gmet_0481"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0481"/>
    <dbReference type="eggNOG" id="COG2241">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031955_1_2_7"/>
    <dbReference type="OMA" id="MPVTQWS"/>
    <dbReference type="OrthoDB" id="1706318at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="EvolutionaryTrace" id="Q39YF0"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11644">
        <property type="entry name" value="Precorrin-6Y-MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012818">
        <property type="entry name" value="CbiE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006365">
        <property type="entry name" value="Cbl_synth_CobL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014008">
        <property type="entry name" value="Cbl_synth_MTase_CbiT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036428">
        <property type="entry name" value="CobL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02467">
        <property type="entry name" value="CbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02469">
        <property type="entry name" value="CbiT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="3E05"/>
        </source>
    </evidence>
    <sequence length="405" mass="44718" checksum="C607FC2048154623" modified="2005-11-22" version="1">MPHQKIYLVGAGIEGWEGFGAKALEVIGKAEVLVGHKRHLDIFSDFTGKKQELGDLSILLEQLRSTDKRTVVLGSGDPNFFGIARFLLRNLPKERIEIFPNVTSVQYAFAQIKEPWDDAIFVSVHGRGLKGAVDRIVAAEKVAVLTDKTNSPAAIARELIARGAEGYEAWLCENLGLPGEKFTRTDVKGLLELPAAELNILILIKAWEPQLAQYPVIGIDDDEFATAKKLITKQEVRAVTLSKLRLQDDLVMWDIGAGSASVSIEASNLMPNGRIFALERNPQYLGFIRDNLKKFVARNVTLVEAFAPEGLDDLPDPDRVFIGGSGGMLEEIIDAVDRRLKSEGVIVLNAVTLDTLTKAVEFLEDHGYMVEVACVNVAKTKGLTEYKMFESHNPVYIITAWKSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YG2</accession>
    <name>Q39YG2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Adenosylcobalamin-5'-phosphate phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobC</name>
        <name evidence="1" type="ordered locus">Gmet_0469</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513838.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0469"/>
    <dbReference type="EnsemblBacteria" id="ABB30712">
        <property type="protein sequence ID" value="ABB30712"/>
        <property type="gene ID" value="Gmet_0469"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0469"/>
    <dbReference type="eggNOG" id="COG0406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033323_8_4_7"/>
    <dbReference type="OMA" id="FWADPYA"/>
    <dbReference type="OrthoDB" id="1122642at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043755">
        <property type="term" value="F:alpha-ribazole phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017578">
        <property type="entry name" value="Ribazole_CobC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="SSF53254"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03162">
        <property type="entry name" value="ribazole_cobC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="201" mass="22460" checksum="D4A20718B4EA3414" modified="2005-11-22" version="1">MTPKTRIHLIRHGEVEGAGPVRRYNGHTDVALSERGRSQYHAIKERFADAPITALYTSDLRRCAWGAEVLGSHLGLTPVRKPELREMGVGIWEGKSWPELMEQYPAEWQARLDDIVNYRVPQGESVLDVHGRVMPVINDIVERHRGEEVLVVAHGGVNRIILLNAIGAPLSSLFAIEQTYCCLNIIDYFADGNTVVKLVNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YN9</accession>
    <name>Q39YN9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein YqeY</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yqeY</name>
        <name evidence="1" type="ordered locus">Gmet_0392</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512364.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0392"/>
    <dbReference type="EnsemblBacteria" id="ABB30635">
        <property type="protein sequence ID" value="ABB30635"/>
        <property type="gene ID" value="Gmet_0392"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0392"/>
    <dbReference type="eggNOG" id="COG1610">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079430_2_1_7"/>
    <dbReference type="OMA" id="AMGAVMK"/>
    <dbReference type="OrthoDB" id="1498741at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="PTHR28055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="SSF89095"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="146" mass="16450" checksum="E35F104945AD6204" modified="2005-11-22" version="1">MLRDRLNDEMKQAMKARDEIRLSVIRLIRSSVKNREIELRHELTDGEITEVLSTLVKQRRESIRMFGEAGRTDLVEKEEKELAVLLTFLPQQLSREEVEALVVQAIADSGAQGPKDMGKVMKAIMPHVTGRADGSLVSVVVKEKLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YS3</accession>
    <name>Q39YS3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sodium-driven efflux pump, MatE and MatE domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">norM</name>
        <name evidence="2" type="ordered locus">Gmet_0358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365660.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0358"/>
    <dbReference type="EnsemblBacteria" id="ABB30601">
        <property type="protein sequence ID" value="ABB30601"/>
        <property type="gene ID" value="Gmet_0358"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0358"/>
    <dbReference type="eggNOG" id="COG0534">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012893_5_3_7"/>
    <dbReference type="OMA" id="FYWRMVS"/>
    <dbReference type="OrthoDB" id="1415498at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006603">
        <property type="entry name" value="DinF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="324"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="452" mass="49331" checksum="DBDEC54A3B29E8A9" modified="2005-11-22" version="1">MTGRGFTTRHFRERKKRISIRRNVMNLSLPVLLSSLFQRLVAIVDIFLVGGLGAAAIAATGLGQLLVFVTMTVFWGLATGTTVVIAHLWGAGQRREARRAAFAACLACAAMTAAASTLGWFFSGDLAAFLGAKDDVLHLAAGYTRLVFLYLAFTTGLNILSAIMHGTGNTRTPMTAILLVNVLHVLMAWPLIYGKLGLPAMGVTGAAIAINASEAIGFFYLLIQAMRLRYIRVGRPDTGLFQRIWRVGWPVALERVAQQGGQLFYSKFIISYGTAAYAAHQIGLSIESLSFMPGAGMGIAAATLMGQALGAKKYRRARISHREALRLAVMVMGTMAAVFLTLPGPLIGLFTHDPAVIEKGIVFLRLVAFAQVPLALSFVYAGSLRGTGDTFYVFLVTLGTMWGVRVFLSWVAADWLHLSLYAVWGVFVIDWYARAVAFWWRYRQRDLHAVVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YV5</accession>
    <name>Q39YV5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Menaquinol oxidoreductase complex Cbc4, iron-sulfur cluster-binding subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cbcT-2</name>
        <name evidence="5" type="ordered locus">Gmet_0326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512298.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0326"/>
    <dbReference type="EnsemblBacteria" id="ABB30569">
        <property type="protein sequence ID" value="ABB30569"/>
        <property type="gene ID" value="Gmet_0326"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0326"/>
    <dbReference type="eggNOG" id="COG0437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_043374_1_3_7"/>
    <dbReference type="OMA" id="RYCMAGC"/>
    <dbReference type="OrthoDB" id="1762646at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13247">
        <property type="entry name" value="Fer4_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="124"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="156"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="28914" checksum="59ADE03488274425" modified="2005-11-22" version="1">MNRRDFLKNSITVIAGLAVPLSALELISPRKLLAQKGDESPVRWAFLVDTQACVGCGFCVKACKTENEIPHETNITRTWVERYVVTRKGKTYVDSPRGARDGFTTDRIDQGEEGYREVKAKDVEKAFFVPKLCNQCDNPACVQVCPVGATYQTPDGVVLVDRKHCIGCAYCIMACPYGVRSFNPAYKTAEKCTFCYHRISKGMKTACVDACPFGARKIGNLRDPDDPVTKTIMSGRVGVLKEQYGTKPQVYYLALSREVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YZ9</accession>
    <name>Q39YZ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion system needle tube protein TssD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tssD</name>
        <name evidence="1" type="ordered locus">Gmet_0280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513597.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0280"/>
    <dbReference type="EnsemblBacteria" id="ABB30525">
        <property type="protein sequence ID" value="ABB30525"/>
        <property type="gene ID" value="Gmet_0280"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0280"/>
    <dbReference type="eggNOG" id="COG3157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116190_1_0_7"/>
    <dbReference type="OMA" id="WEHTTAG"/>
    <dbReference type="OrthoDB" id="1153621at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036624">
        <property type="entry name" value="Hcp1-lik_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008514">
        <property type="entry name" value="T6SS_Hcp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05638">
        <property type="entry name" value="T6SS_HCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141452">
        <property type="entry name" value="SSF141452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03344">
        <property type="entry name" value="VI_effect_Hcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="161" mass="18493" checksum="CBF5FD2B4CC08767" modified="2005-11-22" version="1">MAMPAHLTLTGEKQGKIDGSCELQGREKTILVYSMNHDIHMPKDPHSGLPTGKRVHGPLSIVKEFDASSPKMYQALCTGEHLKDVTLKFYRITKQGTEEHYYTIKLEDAIVVSMKPYMPVTLLEENNPYRHMEEVAFTYRKIKWTWEPNGIEAEDSWSVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZD9</accession>
    <name>Q39ZD9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0136</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512721.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0136"/>
    <dbReference type="EnsemblBacteria" id="ABB30385">
        <property type="protein sequence ID" value="ABB30385"/>
        <property type="gene ID" value="Gmet_0136"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0136"/>
    <dbReference type="eggNOG" id="COG2264">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049382_3_1_7"/>
    <dbReference type="OMA" id="EGENTHE"/>
    <dbReference type="OrthoDB" id="1712450at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="214" mass="22947" checksum="5D9EA16AAD7F55CC" modified="2005-11-22" version="1">MYGRIFTPFAIGGFTIVPEDHPEDPAAGLPLIMGKKGAFGSGEHETTASCLEEMERIPGIAGMRCLDLGSGTGILAVAAIRLGAASVVAVDIDPKAAESCAANVRLNGMEGRIFSVCGELASVGREPYDLLLANIYADIHLALAHEMVGLVRPGGWLILSGIPLQDKFDIQRRFRNLGCIEHDWQILEEYVTIVLRKPDAEGDEMIDEKAASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZG7</accession>
    <name>Q39ZG7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase, AAA_5 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0108</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514113.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0108"/>
    <dbReference type="DNASU" id="3738887"/>
    <dbReference type="EnsemblBacteria" id="ABB30357">
        <property type="protein sequence ID" value="ABB30357"/>
        <property type="gene ID" value="Gmet_0108"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0108"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051820_2_1_7"/>
    <dbReference type="OMA" id="YVYETRE"/>
    <dbReference type="OrthoDB" id="489714at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="1">
        <location>
            <begin position="31"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="292" mass="32955" checksum="2C9D5663DBA8B229" modified="2005-11-22" version="1">MSNLPFHQFCGTEGYVASRALQDVVNVAIALERPLLLKGEPGTGKTLLAYHIAKALGMEIILWNVKSTTKARDGLYTYDTVQRLNDARFGDGDVRDIRHYIKLGPLGRAFGSAERVVLLIDEVDKADIEFPNDLLFELDEMRFHVLETDEWVSAAHRPVVIVTSNSEKELPDAFLRRCVFHYIDFPDETQMRAIIDVHFPDLPAELMRSACKVFYGLREVPGLRKRPSTSELLDWIRVLLASGARLPEEETPALQSVPFLGALVKIQEDADILAHHASRSADVRTAGRRFFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZK7</accession>
    <name>Q39ZK7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coenzyme A pyrophosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514192.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0068"/>
    <dbReference type="EnsemblBacteria" id="ABB30317">
        <property type="protein sequence ID" value="ABB30317"/>
        <property type="gene ID" value="Gmet_0068"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0068"/>
    <dbReference type="eggNOG" id="COG0494">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040940_5_2_7"/>
    <dbReference type="OMA" id="IWGLTAK"/>
    <dbReference type="OrthoDB" id="1623169at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:CoA pyrophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="CoAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="PTHR12992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="SSF55811"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="194" mass="22250" checksum="D2A1BBC5543BF48A" modified="2005-11-22" version="1">MTELVVKQSELPERIRTALANRKRVPMAPGPVPAAILVPLFLEGGEYHILFTKRAEHLNHHRGEISFPGGVRHPDDGGPRETALRETWEEVGIRPGDVDVLGELDDYFSIHNYLVTPVVGIFPPRYPLEVNPDEIERIITVPLTHLLRPEIFRVEDWNWKGRTHPVCFFTYEGDEIWGLTAAILKQFLDLTFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZL3</accession>
    <name>Q39ZL3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional regulator, GntR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0062</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514186.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0062"/>
    <dbReference type="EnsemblBacteria" id="ABB30311">
        <property type="protein sequence ID" value="ABB30311"/>
        <property type="gene ID" value="Gmet_0062"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0062"/>
    <dbReference type="eggNOG" id="COG1802">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017584_5_1_7"/>
    <dbReference type="OMA" id="SAIMNFQ"/>
    <dbReference type="OrthoDB" id="1911275at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07377">
        <property type="entry name" value="WHTH_GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011711">
        <property type="entry name" value="GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008920">
        <property type="entry name" value="TF_FadR/GntR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000524">
        <property type="entry name" value="Tscrpt_reg_HTH_GntR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07729">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00392">
        <property type="entry name" value="GntR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00035">
        <property type="entry name" value="HTHGNTR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00895">
        <property type="entry name" value="FCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00345">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48008">
        <property type="entry name" value="SSF48008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50949">
        <property type="entry name" value="HTH_GNTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH gntR-type" evidence="4">
        <location>
            <begin position="9"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="234" mass="26891" checksum="9E262E48A430B05D" modified="2005-11-22" version="1">MKKTLEKHLTLREKILETIRDAIMTGALRPGEKVAEPDLAERFGISRTPIREAFRQLESEGYLTVIPRKGAVVTAFSPRDVEEFYAIKSILEGYAARRACEKLSSKDIERLRNINDRLRHMADDGDIKHFFRIHNDFHDLFLKAADNEKLYELITNLVRKFQRLRYASLSLPGRMKISVQEHDKIIEAFLKRDPDKAEVLVRKNAEYGGKVLMQNDGAPPLKPAERAAALHLDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZN4</accession>
    <name>Q39ZN4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase, U32 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513807.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0040"/>
    <dbReference type="EnsemblBacteria" id="ABB30290">
        <property type="protein sequence ID" value="ABB30290"/>
        <property type="gene ID" value="Gmet_0040"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0040"/>
    <dbReference type="eggNOG" id="COG0826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011540_4_1_7"/>
    <dbReference type="OMA" id="FSGQCYF"/>
    <dbReference type="OrthoDB" id="1264653at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071704">
        <property type="term" value="P:organic substance metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020988">
        <property type="entry name" value="Pept_U32_collagenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001539">
        <property type="entry name" value="Peptidase_U32"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12392">
        <property type="entry name" value="DUF3656"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01136">
        <property type="entry name" value="Peptidase_U32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3656" evidence="1">
        <location>
            <begin position="402"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="790" mass="86866" checksum="3B43EA482A0A27DA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZQ5</accession>
    <name>HEMH_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ferrochelatase</fullName>
            <ecNumber evidence="1">4.99.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heme synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Protoheme ferro-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hemH</name>
        <name type="ordered locus">Gmet_0019</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 H(+) + heme b = Fe(2+) + protoporphyrin IX</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.99.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ferrochelatase family.</text>
    </comment>
    <dbReference type="EC" id="4.99.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513785.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZQ5"/>
    <dbReference type="SMR" id="Q39ZQ5"/>
    <dbReference type="STRING" id="269799.Gmet_0019"/>
    <dbReference type="PRIDE" id="Q39ZQ5"/>
    <dbReference type="EnsemblBacteria" id="ABB30269">
        <property type="protein sequence ID" value="ABB30269"/>
        <property type="gene ID" value="Gmet_0019"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0019"/>
    <dbReference type="eggNOG" id="COG0276">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018884_4_1_7"/>
    <dbReference type="OMA" id="LGDPYHC"/>
    <dbReference type="OrthoDB" id="780534at2"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="PTHR11108"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0350">Heme biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000019305" description="Ferrochelatase">
        <location>
            <begin position="1"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00323"/>
        </source>
    </evidence>
    <sequence length="317" mass="35817" checksum="C8EE9C2A42F7061D" modified="2005-11-22" version="1">MSEKTAVLLLQMGGPDSLDAVEPFLVNLFSDRDIIRIGPAFLQPFIARLIAKKRATPVERKYEEIGGKSPIRELTEAQAKALEEVLGDGYCCFTAMRYWKPTTVEALAAIRREGITRIIALSLYPHYSRATTGSSVNELKRVLAQSGATFDVTYVDRFFDHPRYIEALAEKIKEGLDDFHPLAEVQILFSAHSLPQSFIDEGDPYLSHIEETVRLVMERFEGVTYHLAFQSRAGPVKWLEPSTEEILEYLAAHQVKNLLMVPLSFVSDHIETLHEIDIEYAMLAHRLGYAKFRRSPSLNTSPLFIDCLADLVRKAGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZR1</accession>
    <name>Q39ZR1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513778.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0013"/>
    <dbReference type="EnsemblBacteria" id="ABB30263">
        <property type="protein sequence ID" value="ABB30263"/>
        <property type="gene ID" value="Gmet_0013"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0013"/>
    <dbReference type="eggNOG" id="COG1131">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_2_7"/>
    <dbReference type="OMA" id="HDPKTDM"/>
    <dbReference type="OrthoDB" id="1926714at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043215">
        <property type="term" value="P:daunorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1900753">
        <property type="term" value="P:doxorubicin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005894">
        <property type="entry name" value="DrrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01188">
        <property type="entry name" value="drrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="5"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="37"/>
            <end position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="308" mass="34412" checksum="9B1A05AA59E99F26" modified="2005-11-22" version="1">MASALSLRGLTKRFGSLTAVDSFSLEVERGTIFALLGPNGAGKTTIIRILTTLLRPDAGTALVEGFDVRQQGKEVRRLIGVVPQENNLDRYLTARENLVMQARLHGMGAAETNGRVDELLELVGLTGRRNDFPDTFSGGMQRRLVVARALVHRPRVLFLDEPTTGLDPQSRRAVWDYVDSLKDSMTIFLTTHYMDEADALCDRIVIMDHGRVLVDGSAARLKERMAHAHCYELRFRANADHYETILAGFPFVRSLQRTGDLFRLSLAGEESLKPLMDAIGTDDIRTICLREPTLEDVFIELTGKEVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="16" xmlns="http://uniprot.org/uniprot">
    <accession>J7LW82</accession>
    <name>J7LW82_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3586</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3586"/>
    <dbReference type="EnsemblBacteria" id="AFR42800">
        <property type="protein sequence ID" value="AFR42800"/>
        <property type="gene ID" value="Gmet_3586"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3586"/>
    <dbReference type="HOGENOM" id="CLU_222182_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="20" mass="2228" checksum="EBF30B293B350583" modified="2012-10-31" version="1">MKKKSYVRPRIVGSAAVHPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="27" xmlns="http://uniprot.org/uniprot">
    <accession>J7LWD2</accession>
    <name>J7LWD2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3622"/>
    <dbReference type="EnsemblBacteria" id="AFR42840">
        <property type="protein sequence ID" value="AFR42840"/>
        <property type="gene ID" value="Gmet_3622"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3622"/>
    <dbReference type="HOGENOM" id="CLU_3099257_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="51" mass="6040" checksum="E39AB3B6CBB2F7C9" modified="2012-10-31" version="1">MLLRLIIPGFSEIDHQIAKLRELRDSFRASNENRSYSRKEPHAFFPPTKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>J7LWE5</accession>
    <name>J7LWE5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3634"/>
    <dbReference type="EnsemblBacteria" id="AFR42850">
        <property type="protein sequence ID" value="AFR42850"/>
        <property type="gene ID" value="Gmet_3634"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3634"/>
    <dbReference type="HOGENOM" id="CLU_2806337_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="67" mass="7925" checksum="DB52EB4C2547D181" modified="2012-10-31" version="1">MSKKEQLCQRAIKFNKLQLYNQSLPDSSISISENFVTPYNIYSSENIQQGPWNYFALWLNFRVDCTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="22" xmlns="http://uniprot.org/uniprot">
    <accession>J7M0B5</accession>
    <name>J7M0B5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3631"/>
    <dbReference type="EnsemblBacteria" id="AFR42847">
        <property type="protein sequence ID" value="AFR42847"/>
        <property type="gene ID" value="Gmet_3631"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3631"/>
    <dbReference type="HOGENOM" id="CLU_3025822_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="55" mass="6416" checksum="9FC5F1D4E9902F58" modified="2012-10-31" version="1">MPYANYINYIILFFVLYLLLLINCLNVIKFLSMDVSDNEMSLLLLVSAQLLHDFS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PQ8</accession>
    <name>YIDC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Membrane protein insertase YidC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Foldase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Membrane integrase YidC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Membrane protein YidC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yidC</name>
        <name type="ordered locus">Gmet_3561</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513717.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39PQ8"/>
    <dbReference type="SMR" id="Q39PQ8"/>
    <dbReference type="STRING" id="269799.Gmet_3561"/>
    <dbReference type="EnsemblBacteria" id="ABB33766">
        <property type="protein sequence ID" value="ABB33766"/>
        <property type="gene ID" value="Gmet_3561"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3561"/>
    <dbReference type="eggNOG" id="COG0706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016535_3_0_7"/>
    <dbReference type="OMA" id="INPVAGC"/>
    <dbReference type="OrthoDB" id="524437at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01810">
        <property type="entry name" value="YidC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019998">
        <property type="entry name" value="Membr_insert_YidC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028055">
        <property type="entry name" value="Membr_insert_YidC/Oxa1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028053">
        <property type="entry name" value="Membr_insert_YidC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038210">
        <property type="entry name" value="YidC_periplasmic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038221">
        <property type="entry name" value="YidC_periplasmic_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="PTHR12428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02096">
        <property type="entry name" value="60KD_IMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14849">
        <property type="entry name" value="YidC_periplas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00701">
        <property type="entry name" value="60KDINNERMP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01900">
        <property type="entry name" value="YIDCPROTEIN"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03593">
        <property type="entry name" value="yidC_nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03592">
        <property type="entry name" value="yidC_oxa1_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0653">Protein transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_1000070100" description="Membrane protein insertase YidC">
        <location>
            <begin position="1"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="5"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="536" mass="58996" checksum="289B6F3BB0ED8FEA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PR5</accession>
    <name>Q39PR5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Amino acid-binding ACT domain regulatory protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3554"/>
    <dbReference type="EnsemblBacteria" id="ABB33759">
        <property type="protein sequence ID" value="ABB33759"/>
        <property type="gene ID" value="Gmet_3554"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3554"/>
    <dbReference type="eggNOG" id="COG2716">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095322_1_1_7"/>
    <dbReference type="OMA" id="SCTMLGG"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="14"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="1">
        <location>
            <begin position="105"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="189" mass="20559" checksum="9F968F02901287B5" modified="2005-11-22" version="1">MMSTKKTDSLAHYAVTVVGKDRPGIVAATAGVLYRLGCNVEDSSSTMLGGEFSMILIVSHEKPFSKGRILEEFRGVAEEMGLTVAARTLSPDEVAYQAPEGELCMVSVYGSDRPGIIYRVTNELAERKVNITDLNTKLIGTKEEPVYVLMLEAALPEGIVVEDVAAMFDKIKKEMNVEISVRSITPVSL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PS9</accession>
    <name>TOLB_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tol-Pal system protein TolB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tolB</name>
        <name type="ordered locus">Gmet_3540</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The Tol-Pal system is composed of five core proteins: the inner membrane proteins TolA, TolQ and TolR, the periplasmic protein TolB and the outer membrane protein Pal. They form a network linking the inner and outer membranes and the peptidoglycan layer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TolB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513696.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39PS9"/>
    <dbReference type="SMR" id="Q39PS9"/>
    <dbReference type="STRING" id="269799.Gmet_3540"/>
    <dbReference type="DNASU" id="3739799"/>
    <dbReference type="EnsemblBacteria" id="ABB33745">
        <property type="protein sequence ID" value="ABB33745"/>
        <property type="gene ID" value="Gmet_3540"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3540"/>
    <dbReference type="eggNOG" id="COG0823">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047123_2_0_7"/>
    <dbReference type="OMA" id="VREPSWG"/>
    <dbReference type="OrthoDB" id="821953at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017038">
        <property type="term" value="P:protein import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00671">
        <property type="entry name" value="TolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="PD40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014167">
        <property type="entry name" value="Tol-Pal_TolB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007195">
        <property type="entry name" value="TolB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04052">
        <property type="entry name" value="TolB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02800">
        <property type="entry name" value="propeller_TolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0574">Periplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_0000259050" description="Tol-Pal system protein TolB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="429" mass="46908" checksum="611427406D727CE3" modified="2005-11-22" version="1" precursor="true">MTRRLFILITIMLCLIPALLHSQEGYREVTAAGTHKLTLTVDSPRRLGGSDAPQVARETAEALQFDMVLAGPFTVTAPSAAAASAGIRPGEFDFAPWRGAGVDLLVKSGYTVTGNAMTMEFRLYNVTQGKEILAKRYTGRPGDVRRIAHTFSDDIMAALTGERGPFTGKIAFVSTRAGAKAIFLMDYDGHNVQQLTKNRSINLNPDFSPSGKEIIFTSYRQGNPDLFRRELFTGAEARISSYRGINATGAWSPDGKTIALTLSKDGNSEIYTISRDGKNPHRLTNTSAIEVSPAWSPDVRKIVFVSDRLGKPQIFIMNADGTGVRRLTTSGNYNVSPRWSPKGDRIVYSRQEGGFQIYAINPDGTNDTRLTSEGSNEHPRWSPDGRFITFSSTRGGGEGIYVMRADGSGQTRVSGGKGRDSHPTWSPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q28</accession>
    <name>Q39Q28_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Purine nucleoside phosphorylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_3434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>adenosine + H(+) + H2O = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:24409"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>adenosine + phosphate = adenine + alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:27642"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:27643"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>inosine + phosphate = alpha-D-ribose 1-phosphate + hypoxanthine</text>
            <dbReference type="Rhea" id="RHEA:27646"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57720"/>
            <dbReference type="EC" id="2.4.2.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27647"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5-thio-alpha-D-ribose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11852"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="EC" id="2.4.2.28"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:11853"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="5 9">Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514662.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3434"/>
    <dbReference type="EnsemblBacteria" id="ABB33646">
        <property type="protein sequence ID" value="ABB33646"/>
        <property type="gene ID" value="Gmet_3434"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3434"/>
    <dbReference type="eggNOG" id="COG1496">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065784_0_0_7"/>
    <dbReference type="OMA" id="CFADCVP"/>
    <dbReference type="OrthoDB" id="1393323at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017061">
        <property type="term" value="F:S-methyl-5-thioadenosine phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd16833">
        <property type="entry name" value="YfiH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.140.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003730">
        <property type="entry name" value="Cu_polyphenol_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038371">
        <property type="entry name" value="Cu_polyphenol_OxRdtase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30616">
        <property type="entry name" value="PTHR30616"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02578">
        <property type="entry name" value="Cu-oxidase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00726">
        <property type="entry name" value="TIGR00726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="266" mass="28345" checksum="1285B914BE98640B" modified="2005-11-22" version="1">MEMKRADKVHYLEPELLTAAGASFHGFTSRHEGVSRPPYNSLNLGVGTNDSPHSVEGNRSLLSRAFGVEAGRLVTVTQVHGTDLLVIDSPNPDYAYFQKLEADGIITNQPGVMIGVCVADCVPVLLLDPVKGVAAALHAGWKGTAAGICRKGVDAFVSLFGSEPRDILAAVGPGIGPCCYEVDTPVAEAFRAGGHDWDAVATIKEMARWQLDLVRANALQLGAAGIPERNIETAPQCVSCAPEFFFSHRRDSGETGRQMGFIMLKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-05-05" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q53</accession>
    <name>ATPD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F(1) sector subunit delta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-type ATPase subunit delta</fullName>
            <shortName evidence="1">F-ATPase subunit delta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpH</name>
        <name type="ordered locus">Gmet_3409</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase delta chain family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514216.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Q53"/>
    <dbReference type="SMR" id="Q39Q53"/>
    <dbReference type="STRING" id="269799.Gmet_3409"/>
    <dbReference type="EnsemblBacteria" id="ABB33621">
        <property type="protein sequence ID" value="ABB33621"/>
        <property type="gene ID" value="Gmet_3409"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3409"/>
    <dbReference type="eggNOG" id="COG0712">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_085114_1_1_7"/>
    <dbReference type="OMA" id="MVDNIQD"/>
    <dbReference type="OrthoDB" id="1937493at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01416">
        <property type="entry name" value="ATP_synth_delta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026015">
        <property type="entry name" value="ATP_synth_OSCP/delta_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000711">
        <property type="entry name" value="ATPase_OSCP/dsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11910">
        <property type="entry name" value="PTHR11910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00213">
        <property type="entry name" value="OSCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00125">
        <property type="entry name" value="ATPASEDELTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47928">
        <property type="entry name" value="SSF47928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01145">
        <property type="entry name" value="ATP_synt_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000370986" description="ATP synthase subunit delta">
        <location>
            <begin position="1"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01416"/>
        </source>
    </evidence>
    <sequence length="180" mass="19380" checksum="28D5AC67E1B54AD0" modified="2005-11-22" version="1">MISNAIARRYAKALVQLGAEEDAVDRFGAELGQFAALLEGNADIDSVLKSPAYRIEAKREILKDVLAKLSLSGTVSNFLQVLLDRGRISFLPQIAHSYAAFADELSGVIRPVLTSAFPLEDAQVESMKGALVKATGKKVQLSVQVEPSLIGGVITKIGDKVFDGSVRTQLNRIQDILQKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q54</accession>
    <name>ATPA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP synthase subunit alpha</fullName>
            <ecNumber evidence="1">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">ATP synthase F1 sector subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">F-ATPase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">atpA</name>
        <name type="ordered locus">Gmet_3408</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + 4 H(+)(in) + H2O = ADP + 5 H(+)(out) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514215.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Q54"/>
    <dbReference type="SMR" id="Q39Q54"/>
    <dbReference type="STRING" id="269799.Gmet_3408"/>
    <dbReference type="PRIDE" id="Q39Q54"/>
    <dbReference type="EnsemblBacteria" id="ABB33620">
        <property type="protein sequence ID" value="ABB33620"/>
        <property type="gene ID" value="Gmet_3408"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3408"/>
    <dbReference type="eggNOG" id="COG0056">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010091_2_1_7"/>
    <dbReference type="OMA" id="LQAPGVM"/>
    <dbReference type="OrthoDB" id="837522at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045261">
        <property type="term" value="C:proton-transporting ATP synthase complex, catalytic core F(1)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1_ATPase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="SSF50615"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0066">ATP synthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0139">CF(1)</keyword>
    <keyword id="KW-0375">Hydrogen ion transport</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000238254" description="ATP synthase subunit alpha">
        <location>
            <begin position="1"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="170"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Required for activity" evidence="1">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01346"/>
        </source>
    </evidence>
    <sequence length="503" mass="54640" checksum="76A7799D188256CC" modified="2005-11-22" version="1">MEIRAEEISEIIRKQIKEYGKEVEVAETGTIISVGDGIARIHGLDKAMAGELLEFPGGVSGMVLNLEEDNVGAAILGEDNENIKEGTTVKRTGRIVEVPVGEALIGRVVNAIGQPIDGKGPINTSTFGKVEVKAPGIVKRKSVHQPMQTGLKAIDAMVPVGRGQRELIIGDRQTGKTAVAIDTIINQKGGDLICIYVAIGQKRSTVAQVVSKLQEHGAMDYTIIVSASASEPAPLQFIAPYTGVTMGEYFRDNGKHALIIYDDLSKQAVAYRQLSLLLRRPPGREAYPGDVFYLHSRLLERAAKLSDDCGAGSLTALPIIETQAGDVSAYIPTNVISITDGQIYLESDLFYSGVRPAINVGLSVSRVGGSAQVKAMKQVAGTLRLNLAQYREMAAFAQFGSDLDKATQMQLARGERLVEILKQPQYRPIPNEKQVLIIFAANNGYVDDYPVASLRRYESELYSFFDGRKADILAELRDKKAIDDDLKGKIVAALDEFKKEFTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-12-16" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QA9</accession>
    <name>NUOC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH-quinone oxidoreductase subunit C</fullName>
            <ecNumber evidence="1">7.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NADH dehydrogenase I subunit C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NDH-1 subunit C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">nuoC</name>
        <name type="ordered locus">Gmet_3353</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + 5 H(+)(in) + NADH = a quinol + 4 H(+)(out) + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:57888"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 30 kDa subunit family.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512579.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QA9"/>
    <dbReference type="SMR" id="Q39QA9"/>
    <dbReference type="STRING" id="269799.Gmet_3353"/>
    <dbReference type="EnsemblBacteria" id="ABB33565">
        <property type="protein sequence ID" value="ABB33565"/>
        <property type="gene ID" value="Gmet_3353"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3353"/>
    <dbReference type="eggNOG" id="COG0852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042628_6_0_7"/>
    <dbReference type="OMA" id="KDIFRGP"/>
    <dbReference type="OrthoDB" id="1735902at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01357">
        <property type="entry name" value="NDH1_NuoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010218">
        <property type="entry name" value="NADH_DH_suC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037232">
        <property type="entry name" value="NADH_quin_OxRdtase_su_C/D-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001268">
        <property type="entry name" value="NADH_UbQ_OxRdtase_30kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020396">
        <property type="entry name" value="NADH_UbQ_OxRdtase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00329">
        <property type="entry name" value="Complex1_30kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143243">
        <property type="entry name" value="SSF143243"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01961">
        <property type="entry name" value="NuoC_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00542">
        <property type="entry name" value="COMPLEX1_30K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0874">Quinone</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-1278">Translocase</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <keyword id="KW-0830">Ubiquinone</keyword>
    <feature type="chain" id="PRO_0000358106" description="NADH-quinone oxidoreductase subunit C">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01357"/>
        </source>
    </evidence>
    <sequence length="162" mass="18515" checksum="5D1FA8B3314043CA" modified="2005-11-22" version="1">MAETNRAVIKLREKFSASVLDVKEFRGEVTVTVKREDIVEICNFLKSSLAYNLCTDVTAVDYLGKQEPRFMVVYNLYSIPNKDRLRVKAGVPEAGCSIDTVSCVWSAANWLEREVYDLMGVVFNNHPDLRRILMTDDWVGHPLRKDYPLQGPGREPYKGRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QD9</accession>
    <name>Q39QD9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512546.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3322"/>
    <dbReference type="EnsemblBacteria" id="ABB33535">
        <property type="protein sequence ID" value="ABB33535"/>
        <property type="gene ID" value="Gmet_3322"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3322"/>
    <dbReference type="eggNOG" id="ENOG5033XMJ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1728769_0_0_7"/>
    <dbReference type="OMA" id="IDNIMGG"/>
    <dbReference type="OrthoDB" id="1477850at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="152" mass="16637" checksum="C8DA9747A3975EEF" modified="2005-11-22" version="1">MSTTTTEQVTLEDHVNAATEVAFLLDIFAATVDTIMGGATASVGRIAGREMARKLPIHLTNPTLDEIVALLNSRMKAGYQFRLEGEGTERVLLFDHCVLQEVCAKRGLTLGTALCRLFHAYLDGILNELICRPVKSEVVSCGDQCRLSLRTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QE7</accession>
    <name>Q39QE7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type VI secretion system protein TssG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tssG</name>
        <name evidence="1" type="ordered locus">Gmet_3314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512538.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3314"/>
    <dbReference type="EnsemblBacteria" id="ABB33527">
        <property type="protein sequence ID" value="ABB33527"/>
        <property type="gene ID" value="Gmet_3314"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3314"/>
    <dbReference type="eggNOG" id="COG3520">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048238_0_0_7"/>
    <dbReference type="OMA" id="RFQNDGE"/>
    <dbReference type="OrthoDB" id="1688251at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010732">
        <property type="entry name" value="T6SS_TssG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35564">
        <property type="entry name" value="PTHR35564"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06996">
        <property type="entry name" value="T6SS_TssG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03347">
        <property type="entry name" value="VI_chp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="329" mass="35956" checksum="064EE8C080B4B862" modified="2005-11-22" version="1">MAAASRIPAAPLEQELLHRGHEFSFLQVLRILELLGERDGTKRPVEVIPRLSLGFPAADVAGVERVGDGYRVIATFLGLYGQATPLPAFYTEELLDEEATDSSAGRDFLDIVNRHIYGIFANVARKYRLFLQVDEQRSDAVTERLHALGGYGEETLRAQLPDPRSLLRYTGLFAQHPRSALGLRTLLTDALDAPVEVISAVPRIVTVPPEERSRLGTIGTLGEDAFVGSEIPDRSGMFRIEVGPLRRDRFAELLPGTPERKRLDLLVALYITDPLAYEIELILAPGEAPPAMLGSGIRLGWDVWMTSGADVGRVSVSFPGGGEPLAAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QG0</accession>
    <name>Q39QG0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">etfA-9</name>
        <name evidence="7" type="ordered locus">Gmet_3301</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3301"/>
    <dbReference type="EnsemblBacteria" id="ABB33514">
        <property type="protein sequence ID" value="ABB33514"/>
        <property type="gene ID" value="Gmet_3301"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3301"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_7"/>
    <dbReference type="OMA" id="ENFHAVL"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="6">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="304" mass="32146" checksum="F412EF329E060A56" modified="2005-11-22" version="1">MLLVGEYREGKLREESYDLVAFADALGAQRSMVLVAPAGTVPTVDGTLYIADAAQCGEYNPEHHKRIILAAVEREDPDCIAFVHSSYGWDLAPRLAVALGAAQVSEVVAVAGDGAYEVNCCNAKLRRAVTPKTPRTILTIQAGAFSLEREPAGMPAIVPLDVPLEPDRIQFDGYEAAEKKGVDLGRAEIVVSAGRGVGKKENVGVIAELAKVLGGELGASRPVVDAKWVDHSHQVGTTGQVVSPKLYVACGISGAIQHVAGMKKADFVVAINKDRDAPIGEVADVLVVADVMQFVPALTARVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QK0</accession>
    <name>Q39QK0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sterol desaturase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512699.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3261"/>
    <dbReference type="EnsemblBacteria" id="ABB33474">
        <property type="protein sequence ID" value="ABB33474"/>
        <property type="gene ID" value="Gmet_3261"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3261"/>
    <dbReference type="eggNOG" id="COG3000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033631_0_1_7"/>
    <dbReference type="OMA" id="QPDYPRD"/>
    <dbReference type="OrthoDB" id="2048011at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="2">
        <location>
            <begin position="88"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="264" mass="29751" checksum="1D977B0076FA4D0E" modified="2005-11-22" version="1">MHDEALIRLAFFFGVLAAVAIWEVAAPRRRLTDSKARRWYTNLSLVAIDTAVVRLTLTVLPADMAVQAREHGWGLMNTVVLPPSAGILLAFIALDLIIYLQHVLFHFLPVLWRLHRMHHTDLDIDVTTGNRFHPVEIFLSAGIKLGAVALLGAPVVAVVAFEVALNATSMFNHGNIRLPLTFDRWLRLVVVTPDMHRVHHSIILRETNSNFGFNLPWWDRLAGTYRPQPEGGHGEMTIGLKEFRDPAQLTLSRLLVQPFVRKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QN6</accession>
    <name>Q39QN6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LysM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512664.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3225"/>
    <dbReference type="EnsemblBacteria" id="ABB33438">
        <property type="protein sequence ID" value="ABB33438"/>
        <property type="gene ID" value="Gmet_3225"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3225"/>
    <dbReference type="eggNOG" id="COG1388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038798_0_0_7"/>
    <dbReference type="OMA" id="GHKWVLP"/>
    <dbReference type="OrthoDB" id="1025063at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223153" evidence="2">
        <location>
            <begin position="30"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="3">
        <location>
            <begin position="82"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="566" mass="61814" checksum="2B0BB1A0F31E0822" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QT0</accession>
    <name>Q39QT0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3181"/>
    <dbReference type="EnsemblBacteria" id="ABB33394">
        <property type="protein sequence ID" value="ABB33394"/>
        <property type="gene ID" value="Gmet_3181"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3181"/>
    <dbReference type="HOGENOM" id="CLU_2395512_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="93" mass="10863" checksum="B03D099E083B297E" modified="2005-11-22" version="1">MLRHRVGEEPPPPYRRIPLRYTVTSLSPELPRSLRRQALAPILISNCFDMIMVVSASSRKNIHEFLWSADEYPMKKHAFKLSLVERIFGELIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QV8</accession>
    <name>Q39QV8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable glycine dehydrogenase (decarboxylating) subunit 1</fullName>
            <ecNumber evidence="4">1.4.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Glycine cleavage system P-protein subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine decarboxylase subunit 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Glycine dehydrogenase (aminomethyl-transferring) subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">gcvPA</name>
        <name evidence="5" type="synonym">gcvP1</name>
        <name evidence="5" type="ordered locus">Gmet_3153</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3 4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GcvP family. N-terminal subunit subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513869.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3153"/>
    <dbReference type="EnsemblBacteria" id="ABB33366">
        <property type="protein sequence ID" value="ABB33366"/>
        <property type="gene ID" value="Gmet_3153"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3153"/>
    <dbReference type="eggNOG" id="COG0403">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_0_2_7"/>
    <dbReference type="OMA" id="MYDGASA"/>
    <dbReference type="OrthoDB" id="870147at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019464">
        <property type="term" value="P:glycine decarboxylation via glycine cleavage system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00712">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023010">
        <property type="entry name" value="GcvPA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42806">
        <property type="entry name" value="PTHR42806"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006815">
        <property type="entry name" value="GcvPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="448" mass="48370" checksum="66B1EC5BFFF2E04D" modified="2005-11-22" version="1">MSTASYCPNTPEEVREMLAAMGAASIDDLFQPIPPGLRARSFDLPAGMSEFEMLRRFEHLAGKNAQHLAHFVGGGYYDHLIPAVVDHLSGRAEFYTAYTPYQPECSQGTLQALFEYQTAICRLTGMEVSNASLYDGGTALAEAAMMALRITGRNRLVIDGAVNPFHREVVRTYLANLDVELVEIGPKLGMEDDLRLRAAIDDATAAVLVQNPNFFGSVSDFRKLAADAHAAGALLVVSAYPVALGLIESPGAMGADVVVGDGQSLGNPLSFGGPSFGFIASRKEYIRNLPGRIIGETVDKKGQRGFVLTLQAREQHIKRHKATSNICSNQSLCALRGLIFLSSLGAQGFAELARLNYDKAEYAKKVLGSLSGVEVMNGGATFNEFTVCLPTIAEEVVTALLRKGVAAGVPLSPYYPEMERCMVVTVTEKRTREEIDTLARHLEGILCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R18</accession>
    <name>Q39R18_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366142.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3092"/>
    <dbReference type="EnsemblBacteria" id="ABB33306">
        <property type="protein sequence ID" value="ABB33306"/>
        <property type="gene ID" value="Gmet_3092"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3092"/>
    <dbReference type="HOGENOM" id="CLU_161787_0_0_7"/>
    <dbReference type="OrthoDB" id="1746225at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025354">
        <property type="entry name" value="DUF4258"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14076">
        <property type="entry name" value="DUF4258"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="114" mass="13504" checksum="CAB55F206026A582" modified="2005-11-22" version="1">MGPMSPQKEQNVIDIIRSCVSRKSIFWTYHVSMRMAERFVPRQIIFASLDTYEIIESYPDDKYLPSYLIRAEHEEVVFHILFALDRDNDAVRIITTYTPSSEKWEADGRTRRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R42</accession>
    <name>Q39R42_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3068</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513627.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33282">
        <property type="protein sequence ID" value="ABB33282"/>
        <property type="gene ID" value="Gmet_3068"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3068"/>
    <dbReference type="eggNOG" id="ENOG5034890">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_479636_0_0_7"/>
    <dbReference type="OMA" id="IANCNAR"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="568" mass="64619" checksum="02B299F1E253A8EA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R96</accession>
    <name>Q39R96_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">50S ribosomal subunit assembly factor BipA</fullName>
            <ecNumber evidence="2">3.6.5.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">GTP-binding protein BipA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">typA</name>
        <name evidence="2" type="synonym">bipA</name>
        <name evidence="4" type="ordered locus">Gmet_3013</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>GTP + H2O = GDP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="2">Binds to ribosomes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514327.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3013"/>
    <dbReference type="EnsemblBacteria" id="ABB33228">
        <property type="protein sequence ID" value="ABB33228"/>
        <property type="gene ID" value="Gmet_3013"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3013"/>
    <dbReference type="eggNOG" id="COG1217">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017016_4_0_7"/>
    <dbReference type="OMA" id="MSMLFTI"/>
    <dbReference type="OrthoDB" id="143460at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03710">
        <property type="entry name" value="BipA_TypA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00849">
        <property type="entry name" value="BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035651">
        <property type="entry name" value="BipA_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042116">
        <property type="entry name" value="TypA/BipA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006298">
        <property type="entry name" value="TypA_GTP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF8">
        <property type="entry name" value="PTHR42908:SF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01394">
        <property type="entry name" value="TypA_BipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="3"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="128"/>
            <end position="131"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="598" mass="65998" checksum="5A71487A0E2FDD00" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RA7</accession>
    <name>Q39RA7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3002</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366133.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3002"/>
    <dbReference type="EnsemblBacteria" id="ABB33217">
        <property type="protein sequence ID" value="ABB33217"/>
        <property type="gene ID" value="Gmet_3002"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3002"/>
    <dbReference type="HOGENOM" id="CLU_782470_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="354" mass="39515" checksum="5E34D36D3644DD93" modified="2005-11-22" version="1">MKMKKILNISNTFTWILISILVLIGLSACCPPFCINQNGDTKNPYVFAYVDTSWNLRFRWSDDGTTWSAAAGTPQNVDFAPGIDTDDVGIYLAIFKASGSYPVRVLRGLYNSWDNTPRTVGDGHPNEIHSGTSIVHIEGEKWLVAYNHYNQAKVVIYDNSYPQDFKAEVTPVSGVAANNNLIDKPALVNRNGKIIVSWLMNNQLQMVTGDIQGGNPVWQPGYLFSANVPEQGFGPPIGAHALARDRQRFYVAVVRQRDPLPGEQISHYFLFIYTSDNGLNWARLTYRETRNPQSMSIAARGTNDIIVILSSPIVTGPANSYRFDGSNWTVLDNSMVFGSYPINAGHDFTLYLRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RG2</accession>
    <name>Q39RG2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512880.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2944"/>
    <dbReference type="EnsemblBacteria" id="ABB33162">
        <property type="protein sequence ID" value="ABB33162"/>
        <property type="gene ID" value="Gmet_2944"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2944"/>
    <dbReference type="eggNOG" id="COG1730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041653_0_0_7"/>
    <dbReference type="OMA" id="YGELHYN"/>
    <dbReference type="OrthoDB" id="801081at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010870">
        <property type="entry name" value="Porin_O/P"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07396">
        <property type="entry name" value="Porin_O_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223292" evidence="1">
        <location>
            <begin position="24"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="420" mass="46461" checksum="59D87F6C711351B7" modified="2005-11-22" version="1">MKKRFIIPTTASFLLAAATLASAATVDELQHQLDDLSGQIKALQAEKAQKPAAAPAPQGEGYLKTVWDRTRIGGYGELDYIMKSDNGNGKGGNTFDPHRFVLYVNSDLADWITLNAELEWEHSGVNDEVKGDELSGEVVVEQAFLDFKLFRPLNVKAGIMLVPVGAINLYHEPTNFNSSERPDLDKYLIPSTWREMGIGIHGSLGDRADYQLLVMNGLDGKEFSAKNGLRDGRQDMNKDNNRGKALTGRLELRPVTNLYTNFSFYTANSAPKGSDNAYTTILAFDGKYRISDFEIAGEYVQVIQDKPGLLASDIGHRMSGYWVEGAYHLMPAALKTGKLAEADLVAFARYSEFDTQQGSIADPTKASGKYDRNYTNFGFSFKPVPTVAIKADYQIYDDHRSGGEKPLDNDKFQVTLGFVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RM5</accession>
    <name>Q39RM5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ADP-heptose--lipopolysaccharide heptosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2881</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514612.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2881"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33099">
        <property type="protein sequence ID" value="ABB33099"/>
        <property type="gene ID" value="Gmet_2881"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2881"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_0_0_7"/>
    <dbReference type="OMA" id="GSKWPTK"/>
    <dbReference type="OrthoDB" id="1326265at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="370" mass="41495" checksum="EB6B34A9565E5885" modified="2005-11-22" version="1">MTLRNVRTDCIHLDGYKPCPPHKRNGVVCGNCAEYRPARSRILILKVGAAGEVIRNTPILHRLRALYPGAEITWMTDYPDFIPRSFVQRVLKFDWKNALLVQEQEYDLLLSLDKDTQVCAVANRVRAAVKKGFLLGPQGKIVPADDDARRKWLTGIFDDLMKENTRHYVEETFEICGWEWAGERYILENVPRVPLSFPRTEGRPLIGLNTGAGSIWPTRIWPEDSWRDLAAALQTRGYDVLLLGGPDEHEKNLRLARESGARYEGLKNFLEFSGLVGCCDLVVTAVTMALHIAIALERRIVLLDNIFNASEFYLYGLGSIVQPELDCLACYKRAFDGGCPVEDCMELISVADVAAAVETNLSAQEPVSSP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RP2</accession>
    <name>Y2864_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0102 protein Gmet_2864</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_2864</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0102 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514595.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39RP2"/>
    <dbReference type="SMR" id="Q39RP2"/>
    <dbReference type="STRING" id="269799.Gmet_2864"/>
    <dbReference type="EnsemblBacteria" id="ABB33082">
        <property type="protein sequence ID" value="ABB33082"/>
        <property type="gene ID" value="Gmet_2864"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2864"/>
    <dbReference type="eggNOG" id="COG0792">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_115353_2_3_7"/>
    <dbReference type="OMA" id="RNWRCGR"/>
    <dbReference type="OrthoDB" id="2044249at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00048">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003509">
        <property type="entry name" value="UPF0102"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34039">
        <property type="entry name" value="PTHR34039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02021">
        <property type="entry name" value="UPF0102"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00252">
        <property type="entry name" value="TIGR00252"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000009220" description="UPF0102 protein Gmet_2864">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00048"/>
        </source>
    </evidence>
    <sequence length="122" mass="13839" checksum="A33151D4EE36301E" modified="2005-11-22" version="1">MSLHNKSLGSKGESLAVTYLERHRYKILERNFRCRGGEIDIVARDGKTIVFVEVKTRTSGHYGPPQLAVTSFKQRQISKAALTWLAKQRQLDACARFDVISITFSGQMPQIEHIPNAFELAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RQ8</accession>
    <name>Q39RQ8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose-phosphate pyrophosphokinase</fullName>
            <shortName evidence="6">RPPK</shortName>
            <ecNumber evidence="6">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">5-phospho-D-ribosyl alpha-1-diphosphate</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl diphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphoribosyl pyrophosphate synthase</fullName>
            <shortName evidence="6">P-Rib-PP synthase</shortName>
            <shortName evidence="6">PRPP synthase</shortName>
            <shortName evidence="6">PRPPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">prsA</name>
        <name evidence="6" type="synonym">prs</name>
        <name evidence="8" type="ordered locus">Gmet_2848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + D-ribose 5-phosphate = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 2 Mg(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514568.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2848"/>
    <dbReference type="EnsemblBacteria" id="ABB33066">
        <property type="protein sequence ID" value="ABB33066"/>
        <property type="gene ID" value="Gmet_2848"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2848"/>
    <dbReference type="eggNOG" id="COG0462">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033546_4_0_7"/>
    <dbReference type="OMA" id="FGWARQD"/>
    <dbReference type="OrthoDB" id="1011035at2"/>
    <dbReference type="UniPathway" id="UPA00087">
        <property type="reaction ID" value="UER00172"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00583_B">
        <property type="entry name" value="RibP_PPkinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRibTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037515">
        <property type="entry name" value="Rib-P_diPkinase_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="PTHR10210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="SSF53271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pribosyltran_N" evidence="7">
        <location>
            <begin position="5"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribose-5-phosphate binding" evidence="6">
        <location>
            <begin position="224"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="38"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="97"/>
            <end position="98"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>D-ribose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB33066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="314" mass="33777" checksum="772287E89C901947" modified="2005-11-22" version="1">MNDKIKVFSGNSNRQLAEKICENLGLPLGKANVKNFSDGEIMVEIAENVRGRDIYVVQSTCAPTNNNLMELLIMNDALKRASAATITAVIPYYGYARQDRKAAPRTPITSKLVADLVTTSGADRVVTVDLHAGQIQGFFNIPVDNLYAAPVILENLKQRFPENGIVMVSPDAGGTERARAFAKRLGCTLAVIDKRRTGPNVAEVMHLIGDVKDKTAIILDDMIDTAGTLTQAAKALKEHGAKAIYACATHGVLSGPAIDRINGSDIEAVVITDTVPLGDKAERTNKIKVLTVADLLAEAIRRIHSDESVSSLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RZ9</accession>
    <name>Q39RZ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2757</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2757"/>
    <dbReference type="EnsemblBacteria" id="ABB32975">
        <property type="protein sequence ID" value="ABB32975"/>
        <property type="gene ID" value="Gmet_2757"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2757"/>
    <dbReference type="eggNOG" id="COG3514">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1765411_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025528">
        <property type="entry name" value="BrnA_antitoxin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14384">
        <property type="entry name" value="BrnA_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="147" mass="16660" checksum="F724E6BF7FCE4427" modified="2005-11-22" version="1">MKVSSDKMYDKYKDLDFTDAEPVSETPVLAKFQAETGGKSRITMRVDNDVLATFKARAEIIGGNYQTLMNDALRQFAQGLRLTDVVREAIHETWETCLTTRSTGRGKKTSRRLALSCRTAKQRHTVDYRPTLALWIVEIDILSAGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S29</accession>
    <name>Q39S29_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Peptidoglycan-binding protein, DUF937 and OmpA domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511733.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2727"/>
    <dbReference type="EnsemblBacteria" id="ABB32945">
        <property type="protein sequence ID" value="ABB32945"/>
        <property type="gene ID" value="Gmet_2727"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2727"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047813_0_0_7"/>
    <dbReference type="OMA" id="NIPEFGI"/>
    <dbReference type="OrthoDB" id="2018797at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009282">
        <property type="entry name" value="DUF937"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06078">
        <property type="entry name" value="DUF937"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="5">
        <location>
            <begin position="282"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="366"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="398" mass="40918" checksum="71D85F03ED21F54D" modified="2005-11-22" version="1">MATNLLEQLSGMFTSDLVGQIGHFLGEGTPAVQKGVPAALSALVGGVAAKGVSTDGASQILGQVRSGGFGENTLSGMAASLAGGEATKGLLEQGNSLVGSLLGNRAGGVAEWLSSVSGLGKGSAQSLLALLAPFVMGKIGKEAQEKDLGAVGLSGLLEGQGPFLQQAAPAGLAGLLGLSSLSGLGGGACPSALFSGPLSKIVWILAGIVVAFLLYTLPQRCSMKTPAIQPAPPQVQAPAVKVDPKLGAFGDVTLPDGVTLNIPEFGIERKLLAFIQDGARPVDKTTWFTFDRLQFETGSAVLKPSSQEQLGNIAAILKAFPQVAIKIGGYTDNVGDPQANLKLSRDRASNTMQELVKLGIDPSRLESEGYGEEHPVADNATEEGRQQNRRIDVRVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S47</accession>
    <name>Q39S47_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis sensory transducer, class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mcp40H-21</name>
        <name evidence="6" type="ordered locus">Gmet_2709</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2709"/>
    <dbReference type="EnsemblBacteria" id="ABB32927">
        <property type="protein sequence ID" value="ABB32927"/>
        <property type="gene ID" value="Gmet_2709"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2709"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_7"/>
    <dbReference type="OMA" id="NLAITHM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="207"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="265"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="537" mass="57323" checksum="76790723BD018AAB" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SA0</accession>
    <name>Q39SA0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511805.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2656"/>
    <dbReference type="EnsemblBacteria" id="ABB32874">
        <property type="protein sequence ID" value="ABB32874"/>
        <property type="gene ID" value="Gmet_2656"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2656"/>
    <dbReference type="eggNOG" id="ENOG50339WY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2494444_0_0_7"/>
    <dbReference type="OrthoDB" id="2094139at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="88" mass="9758" checksum="9FE5C6F1B439D9F5" modified="2005-11-22" version="1">MKREKCPKCGSGKIMHDVRVIDRDGEYANGTLSVQIERKPGALIFKKAETMELHAHICGDCGYAELYAADPSRLWEAYATSRQPGSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SE3</accession>
    <name>Q39SE3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RNA polymerase sigma-24 factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpoE</name>
        <name evidence="2" type="ordered locus">Gmet_2612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511849.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2612"/>
    <dbReference type="DNASU" id="3739997"/>
    <dbReference type="EnsemblBacteria" id="ABB32831">
        <property type="protein sequence ID" value="ABB32831"/>
        <property type="gene ID" value="Gmet_2612"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2612"/>
    <dbReference type="eggNOG" id="COG1595">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_047691_15_2_7"/>
    <dbReference type="OMA" id="IVQDSMM"/>
    <dbReference type="OrthoDB" id="1914729at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039425">
        <property type="entry name" value="RNA_pol_sigma-70-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013249">
        <property type="entry name" value="RNA_pol_sigma70_r4_t2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43133">
        <property type="entry name" value="PTHR43133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08281">
        <property type="entry name" value="Sigma70_r4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma70_r4_2" evidence="1">
        <location>
            <begin position="125"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="186" mass="21410" checksum="01DC0B078E49CDEE" modified="2005-11-22" version="1">MRIKEERLDSTEILNRFLAGIERRAFRMARLATSDDDEALDLVHDAMLAFVNRYAGKPEGEWAPLFHRTLQNRIVDWHRRTGVRNRFRAWFLGGESEEESDPLENVADLSSPDPLASLQRHDLGEAIESAVRRLPLRQRQAFLLRAWEGLDTAQTAFAMGCSEGSVKTHYSRAVHTLRDYLEEYAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SN5</accession>
    <name>Q39SN5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux pump, RND family, inner membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2518</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514533.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2518"/>
    <dbReference type="EnsemblBacteria" id="ABB32739">
        <property type="protein sequence ID" value="ABB32739"/>
        <property type="gene ID" value="Gmet_2518"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2518"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_7"/>
    <dbReference type="OMA" id="GIDREVH"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="912"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1041" mass="113805" checksum="E929B1BC18E0CA73" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SP1</accession>
    <name>Q39SP1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex</fullName>
            <ecNumber evidence="4">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bkdF</name>
        <name evidence="7" type="ordered locus">Gmet_2511</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514775.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2511"/>
    <dbReference type="EnsemblBacteria" id="ABB32733">
        <property type="protein sequence ID" value="ABB32733"/>
        <property type="gene ID" value="Gmet_2511"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2511"/>
    <dbReference type="eggNOG" id="COG0508">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016733_10_0_7"/>
    <dbReference type="OMA" id="HPCIMAP"/>
    <dbReference type="OrthoDB" id="1626282at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="SSF47005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="106"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="387" mass="42581" checksum="DE1F647A7092AAE7" modified="2005-11-22" version="1">MPFDFKLPDLGEGITEAELRKWLVKEGDTVREHQPVAEVETDKAVVEVPSPRGGRVGRLARREGETVAVGATLFTIEEEGEAPPERPKSVGIVGELPEAEEAREVIATPLVRKLARERGIDLATVRGSGPRGSITPDDLEKVSAPVAQPAESFGPVELVPLRGVRRAVARNVMASQRNTAFVTGMEEADITELWELRRRELGAVETRGAHLTFLPFFIKAVQHALREHPYLNAAIDDTAETIILKRHYHFGIAVETPDGLMVPVIRDVDRKSIIELAAEIQGLGSKARKRTISLDELKGSTFTLTNYGHFGGVFATPIINWPDVAILGFGRIGERPWIHKGQIAIRRILPLSLTFDHRVTDGADAAQFLLKVVAYLEDPALLFIEST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SP2</accession>
    <name>Q39SP2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Branched-chain 2-oxoacid dehydrogenase complex, E1 protein, beta subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">bkdB</name>
        <name evidence="2" type="ordered locus">Gmet_2510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514776.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2510"/>
    <dbReference type="EnsemblBacteria" id="ABB32732">
        <property type="protein sequence ID" value="ABB32732"/>
        <property type="gene ID" value="Gmet_2510"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2510"/>
    <dbReference type="eggNOG" id="COG0022">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_012907_1_0_7"/>
    <dbReference type="OMA" id="SEAYYMA"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="4"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="320" mass="34893" checksum="F3DE619594458EE5" modified="2005-11-22" version="1">MPQLNMVQAINLALREEMARDDRVVLLGEDVGRDGGVFRITEGLFEEFGPKRVIDTPLSESAIVGAAVGMAAYGLRPVAEIQFMGFIYAAFDQLFAHAVRIRTRSRGRFTAPLVVRTPYGAGIKAPELHEESTEAFFCHMPGVKVVVPSGPYNAKGLLMAAIRDPDPVLFLEPTRLYRMVKEEVPEGEYTIPLGKARIARPGNAVTVVAWGSMLQRVMKAVEGYDAEVIDPMTLSPFDWEALLASVEKTGRLVVAHEAPLTCGLGAEIAATVAQEAILHLRGPVIRVAGPDTPVPLAKLIDHYLPSPERIRAALDDVLQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SU7</accession>
    <name>Q39SU7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Apocytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">resA</name>
        <name evidence="6" type="ordered locus">Gmet_2452</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2009-10" db="PDB data bank">
            <title>The crystal structure of thioredoxin protein from Geobacter metallireducens.</title>
            <authorList>
                <person name="Zhang Z."/>
                <person name="Burley S.K."/>
                <person name="Swaminathan S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 28-170</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512448.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="3KCM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.45 A"/>
        <property type="chains" value="A/B/C/D/E/F=28-170"/>
    </dbReference>
    <dbReference type="PDBsum" id="3KCM"/>
    <dbReference type="SMR" id="Q39SU7"/>
    <dbReference type="STRING" id="269799.Gmet_2452"/>
    <dbReference type="DNASU" id="3740336"/>
    <dbReference type="EnsemblBacteria" id="ABB32677">
        <property type="protein sequence ID" value="ABB32677"/>
        <property type="gene ID" value="Gmet_2452"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2452"/>
    <dbReference type="eggNOG" id="COG0526">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042529_11_0_7"/>
    <dbReference type="OMA" id="FQMLAIS"/>
    <dbReference type="OrthoDB" id="1617952at2"/>
    <dbReference type="EvolutionaryTrace" id="Q39SU7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016209">
        <property type="term" value="F:antioxidant activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012640">
        <property type="entry name" value="Membr_lipoprot_lipid_attach_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08139">
        <property type="entry name" value="LPAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223080" evidence="4">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="26"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="64"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="3KCM"/>
        </source>
    </evidence>
    <sequence length="170" mass="18930" checksum="B52A07E3D8E5D03B" modified="2005-11-22" version="1">MRKIFLILPILFLLALTGCSKESKPPVEENPAPDFTLNTLNGEVVKLSDLKGQVVIVNFWATWCPPCREEIPSMMRLNAAMAGKPFRMLCVSIDEGGKVAVEEFFRKTGFTLPVLLDADKRVGKLYGTTGVPETFVIDRHGVILKKVVGAMEWDHPEVIAFLNNELSKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SX0</accession>
    <name>Q39SX0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STAS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512471.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2429"/>
    <dbReference type="EnsemblBacteria" id="ABB32654">
        <property type="protein sequence ID" value="ABB32654"/>
        <property type="gene ID" value="Gmet_2429"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2429"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166047_0_0_7"/>
    <dbReference type="OMA" id="CAAHQSA"/>
    <dbReference type="OrthoDB" id="1935161at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="7"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="120" mass="12609" checksum="4C3B651F97CF39E6" modified="2005-11-22" version="1">MDGLTITREEVGGENATLVLKVNGELTIPFAGEFSTALLDAFDGAGRVLVNLEGVSAVDITGLQLLCSAHRSAYGREKELAVEGLTNPILEEAACLAGFRRHVGCAVDVGKSCIWIGGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SY2</accession>
    <name>Q39SY2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclic diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512483.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2417"/>
    <dbReference type="EnsemblBacteria" id="ABB32642">
        <property type="protein sequence ID" value="ABB32642"/>
        <property type="gene ID" value="Gmet_2417"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2417"/>
    <dbReference type="eggNOG" id="COG3434">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044951_1_1_7"/>
    <dbReference type="OMA" id="RQPIFNR"/>
    <dbReference type="OrthoDB" id="753726at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014408">
        <property type="entry name" value="dGMP_Pdiesterase_EAL/HD-GYP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001633">
        <property type="entry name" value="EAL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035919">
        <property type="entry name" value="EAL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00563">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003180">
        <property type="entry name" value="DiGMPpdiest_YuxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00052">
        <property type="entry name" value="EAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141868">
        <property type="entry name" value="SSF141868"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="201"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="411" mass="46776" checksum="ADAA9E5FEA753514" modified="2005-11-22" version="1">MAEEKFFLGRQPILDREQKLYGFELLFRSADTLHANVTDYLQASASVIFDALSSFGLREILGKHKGFINVNADVLMSEALELLPPEKVVIELLEHVPITETVINRCRELKEKGFSIALDDHVYAPVYEPLYEIVDVIKVDLMRTGMERLQSELETFRHWKPKLLAEKVETYEQYEQCEALGFTYFQGYYFARPVVLTRTRVDVGRLAIIKLFNQLVAEVDIDELESTFKQHPNLIINLLRLVNSVSVGLKSRITSMRHAIMVLGYHQLRRWAMMALFANTAQAVGDNPLLVMAATRARLMELIISEQPTVLYDREYPDRAFMTGILSLADALLKMPIEEVVSPLNLNEDVRQALLAREGELGILLQLVEKIERDDFSAISPLIERFSLSMANLAPVQLAACNWVNGMDDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T09</accession>
    <name>Q39T09_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-acetyl-L-homoserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">metY-1</name>
        <name evidence="5" type="ordered locus">Gmet_2390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514768.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2390"/>
    <dbReference type="EnsemblBacteria" id="ABB32615">
        <property type="protein sequence ID" value="ABB32615"/>
        <property type="gene ID" value="Gmet_2390"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2390"/>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_7"/>
    <dbReference type="OMA" id="TYTLFAH"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="428" mass="46485" checksum="A76F0E5FE6D3DB55" modified="2005-11-22" version="1">MTDTKISFDTLALHAGQEPDPTTLSRAVPIYQTASYAFKSSEHAANLFGLKEFGNIYTRLMNPTSDVLEKRLAELDGGVGALAVASGQAAITYAVLNIAQAGQNIVSTSYLYGGTYNLFHYTLPKLGITVKFVDTSDPENVRRAIDDKTRLVYTESVGNPKNNVDDFEAIARIAHEAGIPFVVDNTVTTSYLFKPLEHGADIVVYSLTKFIGGHGTSIGGAVVDGGKFPWNNGRFPEMTEPDPSYHGLCYWEALGNLSYILKMRITLLRDMGACISPFNSFLFLQGLETLPVRMARHVENARAVAQWLEKHPLVSWVNYPGLASHKDHGNARKYLPKGEGAIIGFGINGGLEAGRRFIDSAKLLSHLANIGDAKSLVIHPASTTHQQLSEEEQLASGVTQDYIRLSIGIEEVADIIADIDQALAASQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T69</accession>
    <name>Q39T69_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UDP-galacturonate 4-epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">uge</name>
        <name evidence="2" type="ordered locus">Gmet_2330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513290.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2330"/>
    <dbReference type="EnsemblBacteria" id="ABB32555">
        <property type="protein sequence ID" value="ABB32555"/>
        <property type="gene ID" value="Gmet_2330"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2330"/>
    <dbReference type="eggNOG" id="COG0451">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_1_7_7"/>
    <dbReference type="OMA" id="EPIKVFN"/>
    <dbReference type="OrthoDB" id="1180629at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epimerase" evidence="1">
        <location>
            <begin position="4"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="336" mass="37695" checksum="7782DAE9B350E5D7" modified="2005-11-22" version="1">MSTVLVTGAAGFIGFHLSQRLLARGDRVVGLDNLNDYYDVNLKLDRLRQLEGREGFRFIRASLADRPALEELFSGERFDAVVNLAAQAGVRYSLKNPHAYVESNLVGFMNILEGCRHHGVKHLVYASSSSVYGANTAMPFSVHHNVDHPVSLYAATKKANELMAHTYSSLYGLPTTGLRFFTVYGPWGRPDMALFLFTKAILEGRPIDVYNHGKMQRDFTYIDDIVEGVMRVMDRTAEPNPSWSGDHPDPGTSYAPYRIYNIGNNSPVELLTFIETIEKCIGKPAEKNFLPIQAGDVPATYADVDDLMNDVGFKPATPIGEGIRRFVEWYREYYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T71</accession>
    <name>Q39T71_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Stationary phase survival protein, YicC family, YicC_N and DUF1732 domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yicC</name>
        <name evidence="3" type="ordered locus">Gmet_2328</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513292.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2328"/>
    <dbReference type="EnsemblBacteria" id="ABB32553">
        <property type="protein sequence ID" value="ABB32553"/>
        <property type="gene ID" value="Gmet_2328"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2328"/>
    <dbReference type="eggNOG" id="COG1561">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076609_1_0_7"/>
    <dbReference type="OMA" id="EIKSVNH"/>
    <dbReference type="OrthoDB" id="1509828at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005229">
        <property type="entry name" value="CHP00255"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013551">
        <property type="entry name" value="DUF1732"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013527">
        <property type="entry name" value="YicC-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30636">
        <property type="entry name" value="PTHR30636"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08340">
        <property type="entry name" value="DUF1732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03755">
        <property type="entry name" value="YicC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00255">
        <property type="entry name" value="TIGR00255"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YicC_N" evidence="1">
        <location>
            <begin position="2"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1732" evidence="2">
        <location>
            <begin position="208"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="292" mass="32796" checksum="AF4586BE25E32CDD" modified="2005-11-22" version="1">MIKSMTGYGKAVVETETGRTTVEIRSVNHRYGEVFVKMPRSFLAFENDVRKAVGDRLKRGKIEVFVQREEGVGGQNQPLVNLPLARAYRDAFERMRSELGLADPVTLPLLLSQRDVLAAREEGADEDILRGELLQAVRGAVEAMEAMRMREGEALLADLRDRRQTLATLIDRVAERAPAVVADYAQKLRERLAQLLADTTLDEARLAQEVALLADRCDVTEELVRFRSHLIQFDETLALAEPVGRKLDFLMQELNREVNTIGSKANDAAMAAIVVELKAELEKIREQVQNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TC2</accession>
    <name>Q39TC2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Plasmid replication initiation factor-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366029.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2276"/>
    <dbReference type="EnsemblBacteria" id="ABB32502">
        <property type="protein sequence ID" value="ABB32502"/>
        <property type="gene ID" value="Gmet_2276"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2276"/>
    <dbReference type="eggNOG" id="ENOG502Z9BF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_639125_0_0_7"/>
    <dbReference type="OMA" id="WANGPEK"/>
    <dbReference type="OrthoDB" id="1140420at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="393" mass="45241" checksum="25062283C68CAF92" modified="2005-11-22" version="1">MAIFTSENNQVVSPSMAESVTRHAQNPPTGNFQFLACGIDTLDLGLFVSWDANWNRTKSYLSEKKEASQGTTGLLDKTDISREFLHHASGKAPNYRYQLQFPEYRVYLAISDKPGASPNVYVTILAEALWHVGLSTLLELLEFDLMSFGGTIERVQPSRCDLCADFRVNPPLAFSLLEILRVSRSRKIRMITNGGDLETYYCGSANSPVQVRIYDKGKEIQKSNKQWFLPIWGVDDPGGVWRVEFQLRRSFLHQYRIKTLDDLWEKVGAIWAYLTGEWFSLRLPDNEKAERRTIHPWWLAVQECRDRFGAFRDAKRTFSSDSMEPIQRTLAHIMGRMISIAAQSGIKDRKEAIRYLGQLLDERTDDDKFREEYRKRLIRLGYRGTLGGSDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TD9</accession>
    <name>Q39TD9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366015.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2259"/>
    <dbReference type="EnsemblBacteria" id="ABB32485">
        <property type="protein sequence ID" value="ABB32485"/>
        <property type="gene ID" value="Gmet_2259"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2259"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_7_1_7"/>
    <dbReference type="OMA" id="DTTETIH"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="8"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="71"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="29510" checksum="256ED0CD15E443A0" modified="2005-11-22" version="1">MKTRDYTIQSVRHALDILEQFRGNSSELCVMDLSRRLQLPKNKIYKLIATLEHHNYLEQNISTKNYRLGIKNMELGQVAMRRMRRLGDSRSVMEALVRECNETLCVSILKGSHAVNMDAVVGDNHLRAIPPIGISIPAHCTAAGKVLIAGLTEEQRLHYVSSCLFKRYTTATITNPKLFLRHLEEVDRQGYALELEEQEVGVKSVSAPIRDYTSRTIGAITVYGPSTRFPDDRMEKELIPLVLKGAMEISDMLGYRQSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TE4</accession>
    <name>Q39TE4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ferritin-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2254</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2254"/>
    <dbReference type="EnsemblBacteria" id="ABB32480">
        <property type="protein sequence ID" value="ABB32480"/>
        <property type="gene ID" value="Gmet_2254"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2254"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1223285_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Rubrerythrin" evidence="2">
        <location>
            <begin position="83"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="226" mass="25629" checksum="7A5139A3BDEC409E" modified="2005-11-22" version="1">MCESGLGLIIYGVAILHLTACGCMLIIYRTVDIDGLRGRRYCYKYMGHGLVSARLPITRLRGKAENGGETMYENKDEGVFETVLKKAVKFETDNIHNYLDAMNIVRNEWAKKTLRRVALAKLVHKNRLEKALIKGRLESSALTRPVPTMNLHYVLPKKMLHSDSDAREALAYAIHVEKGAIDFYNHMANESGGAQNDVLFGQLLAEESLHLQILEDLYEEYFLPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TF1</accession>
    <name>Q39TF1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase, AMP-forming</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366000.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2246"/>
    <dbReference type="EnsemblBacteria" id="ABB32473">
        <property type="protein sequence ID" value="ABB32473"/>
        <property type="gene ID" value="Gmet_2246"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2246"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_0_7"/>
    <dbReference type="OMA" id="WLMQRAF"/>
    <dbReference type="OrthoDB" id="377638at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="13"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="425"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="517" mass="56854" checksum="8A4EB150C5651138" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TF9</accession>
    <name>Q39TF9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA thioesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2238</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the C/M/P thioester hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2238"/>
    <dbReference type="EnsemblBacteria" id="ABB32465">
        <property type="protein sequence ID" value="ABB32465"/>
        <property type="gene ID" value="Gmet_2238"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2238"/>
    <dbReference type="eggNOG" id="COG1946">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032690_0_0_7"/>
    <dbReference type="OMA" id="SQVWFRT"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042171">
        <property type="entry name" value="Acyl-CoA_hotdog"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003703">
        <property type="entry name" value="Acyl_CoA_thio"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11066">
        <property type="entry name" value="PTHR11066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="SSF54637"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="284" mass="31837" checksum="30311ADA5FE40F40" modified="2005-11-22" version="1">MKQILPEILELEQIEENLYRGLSQNLGVNRIYGGQVLGQALAAAGKTVIGRKAHSFHAYFLLMGDNKLPVMYEVDRIHEGHSFATRRVVAIQRGRAIFAMTASFQIEEKGLEHQASMPEVPAPEELPTLVETLGKMAAPNRRLQNFFNNFPIEIRPVKPVNPYASGMYLPFSSVWLRSTDRLSDCVGFHQAALAYASDYGLITTAGLPHDVPSQKGKYLEASLDHALWYHRDFRMDEWVLYVAESPSASNARGFSQGQFFSRDGRLIASVAQEGLIRERRLSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TG0</accession>
    <name>Q39TG0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methylmalonyl-CoA epimerase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2237</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365992.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2237"/>
    <dbReference type="EnsemblBacteria" id="ABB32464">
        <property type="protein sequence ID" value="ABB32464"/>
        <property type="gene ID" value="Gmet_2237"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2237"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_3_1_7"/>
    <dbReference type="OMA" id="GRYAYMD"/>
    <dbReference type="OrthoDB" id="1335734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07249">
        <property type="entry name" value="MMCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017515">
        <property type="entry name" value="MeMalonyl-CoA_epimerase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="162" mass="18415" checksum="63A69F8AA0A6BC4F" modified="2005-11-22" version="1">MAKQPVFKKVLQVGIVVHDLEKAVRTYADDFGIGPWQFYNLDKSNMHDMKMRGEKAEFSMKVAFTDLGGVQLELIEPLDESIYSDFLREHGEGIHHIACGVRNFEETMASMQKKDIKVLLEGTTSAGMGYVYLDTTDALSCITEIYRIPENLQYIPPDKTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TH2</accession>
    <name>Q39TH2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase, flavin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365980.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2225"/>
    <dbReference type="EnsemblBacteria" id="ABB32452">
        <property type="protein sequence ID" value="ABB32452"/>
        <property type="gene ID" value="Gmet_2225"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2225"/>
    <dbReference type="eggNOG" id="COG1053">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011398_4_3_7"/>
    <dbReference type="OMA" id="TCECRPF"/>
    <dbReference type="OrthoDB" id="153138at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008152">
        <property type="term" value="P:metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="SSF56425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD_binding_2" evidence="4">
        <location>
            <begin position="11"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="536" mass="58973" checksum="7F5E2F1AB510DBA3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TJ2</accession>
    <name>Q39TJ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acyl-CoA--carboxylate coenzyme A transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365961.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2205"/>
    <dbReference type="EnsemblBacteria" id="ABB32432">
        <property type="protein sequence ID" value="ABB32432"/>
        <property type="gene ID" value="Gmet_2205"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2205"/>
    <dbReference type="eggNOG" id="COG1788">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_466868_0_0_7"/>
    <dbReference type="OMA" id="MSISHEI"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008410">
        <property type="term" value="F:CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="599" mass="65350" checksum="1783D1DDA34CF858" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TS7</accession>
    <name>Q39TS7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pcmB</name>
        <name evidence="5" type="ordered locus">Gmet_2118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513087.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2118"/>
    <dbReference type="DNASU" id="3739454"/>
    <dbReference type="EnsemblBacteria" id="ABB32347">
        <property type="protein sequence ID" value="ABB32347"/>
        <property type="gene ID" value="Gmet_2118"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2118"/>
    <dbReference type="eggNOG" id="COG0493">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_3_4_7"/>
    <dbReference type="OMA" id="HEATIFE"/>
    <dbReference type="OrthoDB" id="323168at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028261">
        <property type="entry name" value="DPD_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14691">
        <property type="entry name" value="Fer4_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="522"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="578"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="615" mass="66088" checksum="A88391754567126E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TS9</accession>
    <name>Q39TS9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Aromatic catabolism-like sigma-54-dependent transcriptional regulator, XylR and V4R domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513089.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2116"/>
    <dbReference type="EnsemblBacteria" id="ABB32345">
        <property type="protein sequence ID" value="ABB32345"/>
        <property type="gene ID" value="Gmet_2116"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2116"/>
    <dbReference type="eggNOG" id="COG1719">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_119_2_7"/>
    <dbReference type="OMA" id="NVYPIRI"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025943">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004096">
        <property type="entry name" value="V4R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010523">
        <property type="entry name" value="XylR_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02830">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06505">
        <property type="entry name" value="XylR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01590">
        <property type="entry name" value="HTHFIS"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00989">
        <property type="entry name" value="V4R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="SSF111126"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00676">
        <property type="entry name" value="SIGMA54_INTERACT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="238"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="579" mass="64706" checksum="68B701B5ED3ECCD7" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U31</accession>
    <name>Q39U31_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512936.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2014"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32243">
        <property type="protein sequence ID" value="ABB32243"/>
        <property type="gene ID" value="Gmet_2014"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2014"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_0_0_7"/>
    <dbReference type="OMA" id="RIPALCE"/>
    <dbReference type="OrthoDB" id="865276at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="303" mass="34752" checksum="F1A895B767FD21DF" modified="2005-11-22" version="1">MNKVSVVLPTYNCGTYVGVAVESVLQQTYSNYELIIVNDGSTDETDQALAPYLCNNGHIRYIKQGNKGHAGARNTGIRAATGDVIAFIDSDDKWLPEKLGEQVQAMEEDPEVGLVHCNVYGFGENQEVQVRGPLLTQEQLQGYSGYIFDNLYFRKIIITTTTVMIRKSCIDDVGMFDENMTRYGSEDRELFLRILWKYKARYVNKPLAMYRNRSDSEGQNYERMIKGQEYVYEKITSLYGLPQSSKRAVMSKMYQEWAREFYAKGRFADGLTNQVKAIRANPIDMNAYFALKRYARFLFSRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U50</accession>
    <name>Q39U50_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512955.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1995"/>
    <dbReference type="EnsemblBacteria" id="ABB32224">
        <property type="protein sequence ID" value="ABB32224"/>
        <property type="gene ID" value="Gmet_1995"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1995"/>
    <dbReference type="eggNOG" id="ENOG502Z9BS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023617_0_0_7"/>
    <dbReference type="OMA" id="HEWSAEY"/>
    <dbReference type="OrthoDB" id="672269at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223398" evidence="1">
        <location>
            <begin position="23"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="716" mass="78399" checksum="00DA221AD8526269" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UA5</accession>
    <name>Q39UA5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoribosylformylglycinamidine synthase, PurQ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purQ</name>
        <name evidence="1" type="ordered locus">Gmet_1940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511903.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1940"/>
    <dbReference type="EnsemblBacteria" id="ABB32169">
        <property type="protein sequence ID" value="ABB32169"/>
        <property type="gene ID" value="Gmet_1940"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1940"/>
    <dbReference type="eggNOG" id="COG0047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001031_3_0_7"/>
    <dbReference type="OMA" id="LHFVCRD"/>
    <dbReference type="OrthoDB" id="1527083at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010075">
        <property type="entry name" value="PRibForGlyAmidine_synth_PurQ"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001586">
        <property type="entry name" value="FGAM_synth_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="275" mass="30072" checksum="23AA7D18FC12C775" modified="2005-11-22" version="1">MAKARALVITGNGTNCETEAAHACRLGGFDEAVIAHISDLLSGDIRLDDFHFINLTGGFLDGDDLGSAKAQANRFRYAKVNDLAEHLIDQLTRFIEAGKLILGVCNGFQLMVKMGLLPALDGAYLKQTATLTFNDCGRFQDRWVYLKVDPTSPSVYTKGVAKGLYLPMRHGEGKFVVDGPATLAAIEEKHLAVFKYSDAAYDAPTMEFPLNPNGSVNAIAALCDGTGRLMGMMPHPEAFVHRTQHPRWTREELPEEGDGLVLFKNAAEYVKLNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UD7</accession>
    <name>Q39UD7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Bacterioferritin</fullName>
            <ecNumber evidence="3">1.16.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1908</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>4 Fe(2+) + 4 H(+) + O2 = 4 Fe(3+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11148"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.16.3.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3 5">Belongs to the bacterioferritin family.</text>
    </comment>
    <dbReference type="EC" id="1.16.3.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511936.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1908"/>
    <dbReference type="EnsemblBacteria" id="ABB32137">
        <property type="protein sequence ID" value="ABB32137"/>
        <property type="gene ID" value="Gmet_1908"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1908"/>
    <dbReference type="eggNOG" id="COG2193">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104506_2_0_7"/>
    <dbReference type="OMA" id="TPEMLKC"/>
    <dbReference type="OrthoDB" id="1890523at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:cellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00907">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002024">
        <property type="entry name" value="Bacterioferritin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009040">
        <property type="entry name" value="Ferritin-like_diiron"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008331">
        <property type="entry name" value="Ferritin_DPS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00210">
        <property type="entry name" value="Ferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002560">
        <property type="entry name" value="Bacterioferritin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00601">
        <property type="entry name" value="BACFERRITIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00754">
        <property type="entry name" value="bfr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00549">
        <property type="entry name" value="BACTERIOFERRITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50905">
        <property type="entry name" value="FERRITIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0409">Iron storage</keyword>
    <keyword evidence="3 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ferritin-like diiron" evidence="7">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR002560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR002560-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="155" mass="17994" checksum="54AE75A1D5156F38" modified="2005-11-22" version="1">MKGNEKIIEHLNARLAEELTAVNQYFVHAEMCENWGYERLHAMIRKRAIDEMKHAEKLIARILFLEGRPIVSDLNKMHIGEEVPKMHENDRLAEESAIKGYNESIRLAVEVGDNGTRELLESILKDEEEHIDNLEAQLDQLRQMGPQCYLSEQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UE4</accession>
    <name>Q39UE4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC transporter, periplasmic substrate-binding protein, aliphatic sulfonates</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CmpA/NrtA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511943.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1901"/>
    <dbReference type="EnsemblBacteria" id="ABB32130">
        <property type="protein sequence ID" value="ABB32130"/>
        <property type="gene ID" value="Gmet_1901"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1901"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_10_2_7"/>
    <dbReference type="OMA" id="YHEMAPA"/>
    <dbReference type="OrthoDB" id="1832232at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006311">
        <property type="entry name" value="TAT_signal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019546">
        <property type="entry name" value="TAT_signal_bac_arc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10518">
        <property type="entry name" value="TAT_signal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01409">
        <property type="entry name" value="TAT_signal_seq"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51318">
        <property type="entry name" value="TAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="321" mass="35113" checksum="C751B2482ED2FE6A" modified="2005-11-22" version="1">MNRRDFLKTSGLALAAAATPFGRFAWAGGATLSLKIGYLPLTDHLLMIAAEREQFKNIRIKPVRFSSWPEIAEALKNGKIDGGFLLTPMGLALRQKGAPIKVVLLGHRNGSAITVKNSPDINRITDLRGKTVAIPSPFSTHNLLLRKALSEKGLVPGRDVKVIDMAPPEMPVALATGRIHGFMVAEPFGAQAEAQKVGKILVLSKDIWKDHICCTLNLQEKIIQSYPAEVQELVTGLIRTASFIESKPAEAARGSVKILGQRPEIVEKVLTTPQDRLTFRNLAPSRADFVAIQDYMVKFGVAKAKVDLTGYLDDRFAKRKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UG9</accession>
    <name>RNPH_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonuclease PH</fullName>
            <shortName evidence="1">RNase PH</shortName>
            <ecNumber evidence="1">2.7.7.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">tRNA nucleotidyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rph</name>
        <name type="ordered locus">Gmet_1876</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>phosphate + tRNA(n+1) = a ribonucleoside 5'-diphosphate + tRNA(n)</text>
            <dbReference type="Rhea" id="RHEA:10628"/>
            <dbReference type="Rhea" id="RHEA-COMP:17343"/>
            <dbReference type="Rhea" id="RHEA-COMP:17344"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:173114"/>
            <dbReference type="EC" id="2.7.7.56"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homohexameric ring arranged as a trimer of dimers.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.56" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511969.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UG9"/>
    <dbReference type="SMR" id="Q39UG9"/>
    <dbReference type="STRING" id="269799.Gmet_1876"/>
    <dbReference type="EnsemblBacteria" id="ABB32105">
        <property type="protein sequence ID" value="ABB32105"/>
        <property type="gene ID" value="Gmet_1876"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1876"/>
    <dbReference type="eggNOG" id="COG0689">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_050858_0_0_7"/>
    <dbReference type="OMA" id="KGKGQGW"/>
    <dbReference type="OrthoDB" id="1824064at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-exoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009022">
        <property type="term" value="F:tRNA nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd11362">
        <property type="entry name" value="RNase_PH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00564">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002381">
        <property type="entry name" value="RNase_PH_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018336">
        <property type="entry name" value="RNase_PH_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="SSF55666"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01966">
        <property type="entry name" value="RNasePH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01277">
        <property type="entry name" value="RIBONUCLEASE_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0698">rRNA processing</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0819">tRNA processing</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_1000024812" description="Ribonuclease PH">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="124"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <note>substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00564"/>
        </source>
    </evidence>
    <sequence length="238" mass="25724" checksum="7F7BFCC60E2D919F" modified="2005-11-22" version="1">MRSDGREAGSLRGINITRHYIKHAEGAVLVEFGDTKVICTASVEESVPPFLRGKGTGWVTAEYSMLPRSTHTRSSREAARGKIGGRTHEIQRLIGRSLRAVTDLTLLGERSVLIDCDVIQADGGTRTASITGAYVALVDALHLLVERGVLPLLPIKEAVAAVSVGIVDGNILLDLNYVEDSAAEVDMNFVMTSSDRFVEVQGTAESEPFTVEQMDGMRVAAVEGIRKLFSIQNEALSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UT5</accession>
    <name>Q39UT5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1858 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513346.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1758"/>
    <dbReference type="EnsemblBacteria" id="ABB31989">
        <property type="protein sequence ID" value="ABB31989"/>
        <property type="gene ID" value="Gmet_1758"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1758"/>
    <dbReference type="eggNOG" id="ENOG5030IH3">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_180540_1_1_7"/>
    <dbReference type="OMA" id="DCQIADF"/>
    <dbReference type="OrthoDB" id="1961381at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3910.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023883">
        <property type="entry name" value="CHP03980_redox-disulphide"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015077">
        <property type="entry name" value="DUF1858"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038062">
        <property type="entry name" value="ScdA-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39341">
        <property type="entry name" value="PTHR39341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08984">
        <property type="entry name" value="DUF1858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140683">
        <property type="entry name" value="SSF140683"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03980">
        <property type="entry name" value="prismane_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1858" evidence="1">
        <location>
            <begin position="2"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="64" mass="7463" checksum="0D9B653E78131DF2" modified="2005-11-22" version="1">MITKTMRIGDIIRTYPQSLKIFEKYGLDCYECQVADYEELEHGAGVHKTDLEKLLKELNELIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UU6</accession>
    <name>Q39UU6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response receiver-related domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1747</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513357.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1747"/>
    <dbReference type="EnsemblBacteria" id="ABB31978">
        <property type="protein sequence ID" value="ABB31978"/>
        <property type="gene ID" value="Gmet_1747"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1747"/>
    <dbReference type="eggNOG" id="COG0745">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1924563_0_0_7"/>
    <dbReference type="OMA" id="AVLDMIF"/>
    <dbReference type="OrthoDB" id="1718355at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="128" mass="14460" checksum="C7A182C63C00FE23" modified="2005-11-22" version="1">MGKILIVDDDKAFSQFLKRYINQHYPVLKVQICTSPVRALPIISKGDVDLLLVDYEMPVLDGDKVVKYACEVGMDKSRIIVLSSRDADFLHEHFPLGTCLAVMNKYEARQKAVLDMVFSSLQRKAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UX8</accession>
    <name>Q39UX8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Short-chain acyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1715</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514139.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1715"/>
    <dbReference type="EnsemblBacteria" id="ABB31946">
        <property type="protein sequence ID" value="ABB31946"/>
        <property type="gene ID" value="Gmet_1715"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1715"/>
    <dbReference type="eggNOG" id="COG1960">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018204_0_2_7"/>
    <dbReference type="OMA" id="CWISNAP"/>
    <dbReference type="OrthoDB" id="760677at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="SSF47203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="SSF56645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00073">
        <property type="entry name" value="ACYL_COA_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA_dh_N" evidence="8">
        <location>
            <begin position="7"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_M" evidence="7">
        <location>
            <begin position="122"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA_dh_1" evidence="6">
        <location>
            <begin position="229"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="379" mass="41634" checksum="2C57F7FD0DBADD2F" modified="2005-11-22" version="1">MNFELSQDHKVLQDAVRDFVEKEVKPVAVQIDEEHMIPDSLVRKMGEMGFMGSYLPEQYGGAGLDMLSYSIVVEEVSKACGSSGVLISAHTSLACGPIYTFGTEEQKKKWLPALNSGETIGCFLLTEPDAGSDAGAIATTYRREGDEFVINGSKIFITNGGYRGTGVLFATSDKSLKHKGVSAFIIDLRSHGVEILKNEKKLGIRGSYTTAFALDNVRIPAENLLGQEGQGFKIAMDTLNGGRIGIASQALGIAEGAFERALAYSKERKQFGAPICDLQAIQFKLADMWAKIETSKLMTYKAAWLKDHKKNYTMESAMCKMLASEAATYVTKEAIQIHGGYGFICDYEVERMYRDAKITEIYEGTNEVQRVVISKLLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UZ4</accession>
    <name>Q39UZ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1699</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514155.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1699"/>
    <dbReference type="EnsemblBacteria" id="ABB31930">
        <property type="protein sequence ID" value="ABB31930"/>
        <property type="gene ID" value="Gmet_1699"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1699"/>
    <dbReference type="eggNOG" id="COG4258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009099_0_0_7"/>
    <dbReference type="OMA" id="HVMTLVL"/>
    <dbReference type="OrthoDB" id="1756450at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="689"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="811"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="304"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="847" mass="91788" checksum="C3AAAF5BD77C3D49" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V09</accession>
    <name>Q39V09_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Helix-turn-helix transcriptional regulator, LysR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1684</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LysR transcriptional regulatory family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31915.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365859.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1684"/>
    <dbReference type="DNASU" id="3741360"/>
    <dbReference type="EnsemblBacteria" id="ABB31915">
        <property type="protein sequence ID" value="ABB31915"/>
        <property type="gene ID" value="Gmet_1684"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1684"/>
    <dbReference type="eggNOG" id="COG0583">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039613_6_2_7"/>
    <dbReference type="OMA" id="KGIQQNM"/>
    <dbReference type="OrthoDB" id="990666at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005119">
        <property type="entry name" value="LysR_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000847">
        <property type="entry name" value="Tscrpt_reg_HTH_LysR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00126">
        <property type="entry name" value="HTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03466">
        <property type="entry name" value="LysR_substrate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00039">
        <property type="entry name" value="HTHLYSR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50931">
        <property type="entry name" value="HTH_LYSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH lysR-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31915.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="294" mass="33282" checksum="32525B5AE06DEC62" modified="2012-10-31" version="2">MDIRQLQFFAEIVRYGSFTKAAERLHVAQPAVSMAMKKLEEELDLILFNRQERRISLTAEGEIFLRHAEKILDEVKSAETEMEELRGLAKGEVRVGIPPMMSAYFFPEIIRDFSNSYPDLHLTVSGEGASKIQKMIIDGELDMGVVAGASFPETLEVRRFLREEVIVCVPRSHPLASRGSLTLHEFARHPLIFYREGYYLRELILDVLRGAGLSPTIRFETNLYTLVKSLVQKGMGISVFLRMVVAEDDDLTAISLDPPLFLDLLIAWKKHGYLSRANRAFADYLLEKGSSAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V38</accession>
    <name>Q39V38_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rossmann fold nucleotide-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511408.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1655"/>
    <dbReference type="EnsemblBacteria" id="ABB31886">
        <property type="protein sequence ID" value="ABB31886"/>
        <property type="gene ID" value="Gmet_1655"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1655"/>
    <dbReference type="eggNOG" id="COG1832">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112567_1_1_7"/>
    <dbReference type="OMA" id="YVWFQPG"/>
    <dbReference type="OrthoDB" id="1910664at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13380">
        <property type="entry name" value="CoA_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA_binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="134" mass="14653" checksum="E0212C450B4A38C1" modified="2005-11-22" version="1">MNTKEQLDLFFQSKAFGVVGASADRHKYGNKVLRVYQQKNLRVIPVNPKEQEIEGTACVPNVTGLPDDVESISVITPPPVTEQVVEMAARKGIKNIWMQPGAESDAAVEACRRHGISVIADGTCILVVLGYHDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V49</accession>
    <name>Q39V49_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pyridoxal-5'-phosphate-dependent decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the group II decarboxylase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511420.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1644"/>
    <dbReference type="DNASU" id="3740413"/>
    <dbReference type="EnsemblBacteria" id="ABB31875">
        <property type="protein sequence ID" value="ABB31875"/>
        <property type="gene ID" value="Gmet_1644"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1644"/>
    <dbReference type="eggNOG" id="COG0076">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011856_0_4_7"/>
    <dbReference type="OMA" id="RHATYHA"/>
    <dbReference type="OrthoDB" id="1478871at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016830">
        <property type="term" value="F:carbon-carbon lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022517">
        <property type="entry name" value="Asp_decarboxylase_pyridox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03799">
        <property type="entry name" value="NOD_PanD_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="550" mass="60722" checksum="3A6F81B10475A03F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VN4</accession>
    <name>Q39VN4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1456</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511614.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1456"/>
    <dbReference type="DNASU" id="3740477"/>
    <dbReference type="EnsemblBacteria" id="ABB31690">
        <property type="protein sequence ID" value="ABB31690"/>
        <property type="gene ID" value="Gmet_1456"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1456"/>
    <dbReference type="eggNOG" id="COG1047">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1331">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_677495_0_0_7"/>
    <dbReference type="OMA" id="VWIRVNS"/>
    <dbReference type="OrthoDB" id="1332766at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223432" description="Peptidylprolyl isomerase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="288"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="406" mass="43655" checksum="5CEEA1FAD3EB95C9" modified="2005-11-22" version="1">MNRTATSKIVAMMLVVAVAIPALAAEPRNGESAGADAVLTKAIEDALGNGTGSVTVDLPQAEGKAKAGDLVTLRYTMTTADGALVATTEESVAADKGRPRSVAFTARSRYRPEEIVAGGEGNLPGVAEAVIGMAPGEKKHLSLSADKAFGARDPQRVVTMATVKSLPRTVAIPAADYVKNFGALPVVGKELPVVPYFPARVIEVTEQQAKLQLLARDGERFTESFGAVETKVDGESVKIRLVPTIGAPFEFRGARGTITAAGEENFTVDFNHPLADRSVVLDLEVVSLTKGEKLAAISVPWLENHDQGLEKAKQEEKPAVLVLYADWCQWCKKLFGETAEDPRIKAVSDRFVWIRVNSDKEKAYKEQYGQDGYPLIVLLDRQGKVAKKLDGFRDAAGLREELNALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VU7</accession>
    <name>Q39VU7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Type IV pilus biogenesis ATPase PilB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">pilB</name>
        <name evidence="5" type="ordered locus">Gmet_1393</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="3">
        <citation type="journal article" date="2017" name="Nat. Commun." volume="8" first="15091" last="15091">
            <title>The molecular mechanism of the type IVa pilus motors.</title>
            <authorList>
                <person name="McCallum M."/>
                <person name="Tammam S."/>
                <person name="Khan A."/>
                <person name="Burrows L.L."/>
                <person name="Howell P.L."/>
            </authorList>
            <dbReference type="PubMed" id="28474682"/>
            <dbReference type="DOI" id="10.1038/ncomms15091"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) IN COMPLEX WITH ADP; ATP ANALOG AND ZINC</scope>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2019-04" db="PDB data bank">
            <title>Multiple conformations facilitate PilT function in the type IV pilus.</title>
            <authorList>
                <person name="McCallum M."/>
                <person name="Benlekbir S."/>
                <person name="Nguyen S."/>
                <person name="Tammam S."/>
                <person name="Rubinstein J.L."/>
                <person name="Burrows L.L."/>
                <person name="Howell PL."/>
            </authorList>
        </citation>
        <scope>STRUCTURE BY ELECTRON MICROSCOPY (7.80 ANGSTROMS)</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513115.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="5TSG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="3.40 A"/>
        <property type="chains" value="B/C/D=1-568"/>
    </dbReference>
    <dbReference type="PDB" id="5TSH">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-568"/>
    </dbReference>
    <dbReference type="PDB" id="6OLJ">
        <property type="method" value="EM"/>
        <property type="resolution" value="7.80 A"/>
        <property type="chains" value="A/B/C/D/E/F=1-568"/>
    </dbReference>
    <dbReference type="PDBsum" id="5TSG"/>
    <dbReference type="PDBsum" id="5TSH"/>
    <dbReference type="PDBsum" id="6OLJ"/>
    <dbReference type="SMR" id="Q39VU7"/>
    <dbReference type="STRING" id="269799.Gmet_1393"/>
    <dbReference type="EnsemblBacteria" id="ABB31627">
        <property type="protein sequence ID" value="ABB31627"/>
        <property type="gene ID" value="Gmet_1393"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1393"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_10_1_7"/>
    <dbReference type="OMA" id="NMGVPAF"/>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009297">
        <property type="term" value="P:pilus assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013374">
        <property type="entry name" value="ATPase_typ4_pilus-assembl_PilB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02538">
        <property type="entry name" value="type_IV_pilB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="T2SP_E" evidence="4">
        <location>
            <begin position="384"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="327"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="332"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="461"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 8">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>Zinc</name>
            <dbReference type="ChEBI" id="CHEBI:27363"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="5TSG"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="5TSH"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="6OLJ"/>
        </source>
    </evidence>
    <sequence length="568" mass="62658" checksum="62E51B6301B078F9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VU9</accession>
    <name>Q39VU9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Polyprenyl-phospho-glycoside--protein O-glycosyltransferase DUF2723 membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513117.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1391"/>
    <dbReference type="EnsemblBacteria" id="ABB31625">
        <property type="protein sequence ID" value="ABB31625"/>
        <property type="gene ID" value="Gmet_1391"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1391"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_440600_0_0_7"/>
    <dbReference type="OMA" id="KAPNDPQ"/>
    <dbReference type="OrthoDB" id="332676at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021280">
        <property type="entry name" value="DUF2723"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11028">
        <property type="entry name" value="DUF2723"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="619" mass="69289" checksum="AE0DFCF5853694AC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VZ6</accession>
    <name>Q39VZ6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic polysaccharide biosynthesis/export protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1344</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1344"/>
    <dbReference type="EnsemblBacteria" id="ABB31578">
        <property type="protein sequence ID" value="ABB31578"/>
        <property type="gene ID" value="Gmet_1344"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1344"/>
    <dbReference type="eggNOG" id="COG1596">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_645234_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015159">
        <property type="term" value="F:polysaccharide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003715">
        <property type="entry name" value="Poly_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019554">
        <property type="entry name" value="Soluble_ligand-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02563">
        <property type="entry name" value="Poly_export"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10531">
        <property type="entry name" value="SLBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="SSF49265"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223363" evidence="3">
        <location>
            <begin position="26"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="SLBB" evidence="4">
        <location>
            <begin position="367"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="397"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="425" mass="45498" checksum="EC2FCB726088F997" modified="2005-11-22" version="1">MKRSIQSAFLFFLGGVFAIAAVAWAVEPNGAGRGYTGSQWDVSGPGGGYGVQTAPQAGGYMMQGAPLSGSGYAVQGVQQPGGYAVPGSMQPGGYGVTAPGGYGAPQVPGAIQYQQDTEQEQGLRLMDEGKEVEQGPKLLLKAEPGDGMVSLSWTVTGVRRKAEDIPPRFVVLYGSEPEKYLKAVPVGDTTSFRVRELKNNQIYYFRIQGLPGPGQRQLKALVSEEMKAMPVPVEELGSPLERAFARKSPTLLDKIEPTPVDRTLKQFGYEFFKNSIANLPAVDNLPVGSDYVIGPGDKLRIDVWGSLQARYDAPVDRNGEVTIPRVGAVKVWGLSYGQAKDAINKAFSRYYKGYELNVTLGSLRTIQVYVVGEVEVPGTYNVSSLATVINALAAAGGPSKNGSLRSIRISRGGRRSRRSTSTTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W15</accession>
    <name>Q39W15_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">dTDP-3-amino-3,6-dideoxy-D-galactose N-acetyltransferase and dTDP-6-deoxy-D-hex-4-ulose isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">fdtA</name>
        <name evidence="2" type="synonym">fdtC</name>
        <name evidence="2" type="ordered locus">Gmet_1324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1324"/>
    <dbReference type="DNASU" id="3740296"/>
    <dbReference type="EnsemblBacteria" id="ABB31559">
        <property type="protein sequence ID" value="ABB31559"/>
        <property type="gene ID" value="Gmet_1324"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1324"/>
    <dbReference type="eggNOG" id="COG0110">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_949059_0_0_7"/>
    <dbReference type="OMA" id="VWAFAHI"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20292">
        <property type="entry name" value="cupin_QdtA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008894">
        <property type="entry name" value="QdtA_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05523">
        <property type="entry name" value="FdtA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FdtA" evidence="1">
        <location>
            <begin position="180"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="309" mass="33690" checksum="08C50C813A2B3047" modified="2005-11-22" version="1">MKIHPLSDVQAKQIGQGTSIWQYVVVLPGAVIGSDCNICSHCFIENAVVIGDRVTIKCGVQIWDGLRVEDDVFIGPNVTFTNDLFPRSKQHPKEFAKTVIQKGASIGANATILAGSTIGRNAMVGAGAVVTKSVPPNAIVVGNPARITGYVSTIPAQQKHSEIEVGENIGTVGQSAIPGVQFVRLPIIPDLRGSLSFAEFGQYLPFIPKRYFLVFDVQSREVRGEHAHKELHQFLVCVKGACSVMVDDGNCREEYILNTPGAALHIPPLVWGVQYKYSPDAVLMVLASDVYKPEDYIRDYDQFIALVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W71</accession>
    <name>Q39W71_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMP nucleosidase</fullName>
            <ecNumber evidence="2">3.2.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">AMP nucleosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>AMP + H2O = adenine + D-ribose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:20129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="3.2.2.4"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="3.2.2.4" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512100.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1267"/>
    <dbReference type="EnsemblBacteria" id="ABB31503">
        <property type="protein sequence ID" value="ABB31503"/>
        <property type="gene ID" value="Gmet_1267"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1267"/>
    <dbReference type="eggNOG" id="COG1611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058336_0_2_7"/>
    <dbReference type="OMA" id="FYRVYHS"/>
    <dbReference type="OrthoDB" id="902542at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008714">
        <property type="term" value="F:AMP nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00730">
        <property type="entry name" value="TIGR00730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00031983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="342" mass="39482" checksum="1A7EAC1BB165F33E" modified="2005-11-22" version="1">MELNFTRTNGEIDTLIDTLMEKVDAIHHPAMIREMIISALKSGQECDYLADLKLLNNTMKEMRYTTNVFAPYREKRKVTIFGSARTEPQESIYQTCVRFSRKLAEKGFMIITGGGPGIMQAGNEGAGSEHSFAVNIRLPFEQQPNPVMLKNPRLINYKYFFNRKVAFVKESNALAVFPGGFGTLDEAMEVFTLIQTGKTSPKPLVLIDDNTGYWDRWFDFVKNCILGKGFISAEDFSIFTITRDEDEAIRVIDDFYRNYHSLRFFERRLIIRLNKELTPEQIEELENEFPELRLPGTRILPCAPLPEEADEPNLLKLPRISLQFNHQHYGLLIAFIRKLNMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WB1</accession>
    <name>Q39WB1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4124 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1226</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512143.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1226"/>
    <dbReference type="EnsemblBacteria" id="ABB31463">
        <property type="protein sequence ID" value="ABB31463"/>
        <property type="gene ID" value="Gmet_1226"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1226"/>
    <dbReference type="eggNOG" id="ENOG502ZHC8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_123270_0_0_7"/>
    <dbReference type="OMA" id="NFTEEYS"/>
    <dbReference type="OrthoDB" id="1974675at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025392">
        <property type="entry name" value="DUF4124"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13511">
        <property type="entry name" value="DUF4124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223558" description="DUF4124 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4124" evidence="3">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="180" mass="20018" checksum="D6CD6F811FA0FB8C" modified="2005-11-22" version="1">MTRFACTVMILALAVAAQADIYKWVDQRGTVNYTEDLGKVPKKYRKKVTVIPEGGAPAAEVTETVVERGGKEKKPETGQKEVENALAPKQEKKKMVYGGKDEDAWKTEFRTLRSEIKANEAELAARRGRLANPGTMNRGDFLGVQREAKRIEETLTGLNTKLNTLEESAQRAGVPLELRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WE5</accession>
    <name>Q39WE5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512178.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1192"/>
    <dbReference type="EnsemblBacteria" id="ABB31429">
        <property type="protein sequence ID" value="ABB31429"/>
        <property type="gene ID" value="Gmet_1192"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1192"/>
    <dbReference type="eggNOG" id="ENOG502ZUZ5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_068446_0_0_7"/>
    <dbReference type="OMA" id="WITQLQL"/>
    <dbReference type="OrthoDB" id="1381369at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044384">
        <property type="term" value="C:host outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000758">
        <property type="entry name" value="Enterovir_OMP"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00695">
        <property type="entry name" value="ENT_VIR_OMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223213" evidence="1">
        <location>
            <begin position="20"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="320" mass="35868" checksum="DF0A07D3E591C8B4" modified="2005-11-22" version="1">MRRLALAMLLLIFASPVAAEEIHILGGYGVDSNPNRKAGAYQIEYLEGLGEHFAFSLSYLNQGHFPEHHRDGNSFNLWLRTNQLHPQLSLAAGIGVMYYYDTTHPPPGTPSEDVHGLASMYSLAATWYTESRVIFQLQTYWVKANASFDTVSALVGIGYQLDAPPKPGPLAKAPPQTKRTTENELTLLGGQTIVNVPGDGHSQALSLEYRRGIWRFVEMTAAALYEGRSTLCDRYGLTTQLWLARPFFDDHVALGIGFGPYFAVDRRRQNDNEVFIPTIFTASAGFRLTPHWLIRASWNRVITNYNRDSDIFMGGIGYRF</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WF4</accession>
    <name>SYY_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Tyrosyl-tRNA synthetase</fullName>
            <shortName evidence="1">TyrRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">tyrS</name>
        <name type="ordered locus">Gmet_1182</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + H(+) + L-tyrosyl-tRNA(Tyr)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513448.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39WF4"/>
    <dbReference type="SMR" id="Q39WF4"/>
    <dbReference type="STRING" id="269799.Gmet_1182"/>
    <dbReference type="EnsemblBacteria" id="ABB31420">
        <property type="protein sequence ID" value="ABB31420"/>
        <property type="gene ID" value="Gmet_1182"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1182"/>
    <dbReference type="eggNOG" id="COG0162">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024003_5_0_7"/>
    <dbReference type="OMA" id="YMMAKDS"/>
    <dbReference type="OrthoDB" id="402899at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00805">
        <property type="entry name" value="TyrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02007">
        <property type="entry name" value="Tyr_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024088">
        <property type="entry name" value="Tyr-tRNA-ligase_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024108">
        <property type="entry name" value="Tyr-tRNA-ligase_bac_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766">
        <property type="entry name" value="PTHR11766"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11766:SF1">
        <property type="entry name" value="PTHR11766:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00234">
        <property type="entry name" value="tyrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <feature type="chain" id="PRO_0000236720" description="Tyrosine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="S4 RNA-binding" evidence="1">
        <location>
            <begin position="341"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="229"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02007"/>
        </source>
    </evidence>
    <sequence length="403" mass="45025" checksum="BCF7B06080CB6B47" modified="2005-11-22" version="1">MSVAEQMAIIKRGATEILLEKELEEKIEKSLSTGVPLRIKAGFDPTAPDLHLGHTVLLHKMRQFQQLGHEVCFLIGDFTGMIGDPTGKSETRKALTREDVLKNAETYKEQVFKILDPKKTRVVFNSEWLGKMTASDMIGLAAQSTVARMLERDDFGKRFANQLPISIHEFLYPLIQGYDSVALKADVELGGTDQKFNLLVGRELQRVWKQSPQSVITMPLLEGLDGVNKMSKSLGNYIGINEPADEIFGKIMSISDELMLRYYELLSDLTLAEIEKLKAAMRDGDVHPMAAKKQLAREIVARYHGAVAADNAEESFVRRFRDNQTPEEMPECILSAEEGKVLLGRLLAEAGLVKSNSEGRRAINQGGVKVNGEKVTNDMLELPGVGEYVLQFGKRRFARIVFK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WH4</accession>
    <name>FOLD2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein FolD 2</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methylenetetrahydrofolate dehydrogenase</fullName>
                <ecNumber evidence="1">1.5.1.5</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">Methenyltetrahydrofolate cyclohydrolase</fullName>
                <ecNumber evidence="1">3.5.4.9</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">folD2</name>
        <name type="ordered locus">Gmet_1162</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:22812"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,10-methenyltetrahydrofolate + H2O = (6S)-10-formyltetrahydrofolate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57454"/>
            <dbReference type="ChEBI" id="CHEBI:57455"/>
            <dbReference type="EC" id="3.5.4.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.5" evidence="1"/>
    <dbReference type="EC" id="3.5.4.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513427.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39WH4"/>
    <dbReference type="SMR" id="Q39WH4"/>
    <dbReference type="STRING" id="269799.Gmet_1162"/>
    <dbReference type="EnsemblBacteria" id="ABB31400">
        <property type="protein sequence ID" value="ABB31400"/>
        <property type="gene ID" value="Gmet_1162"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1162"/>
    <dbReference type="eggNOG" id="COG0190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034045_2_1_7"/>
    <dbReference type="OMA" id="HIVGRPM"/>
    <dbReference type="OrthoDB" id="1449514at2"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminiacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="SSF53223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0486">Methionine biosynthesis</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0554">One-carbon metabolism</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000268359" description="Bifunctional protein FolD 2">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="164"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01576"/>
        </source>
    </evidence>
    <sequence length="285" mass="30179" checksum="5CE21B382B24171F" modified="2005-11-22" version="1">MSTIIDGKAIAAKLRAEIATEVKILKEKGIIPGLATVLVGEDPASEVYVRMKGNACQELGMHSVKHTLPATTTEAELLALVARLNSDPTIHGILVQLPLPKQINSDTILEAISPVKDVDGFHPYNVGRLMVGKPTFQPCTPYGVMVMLREAGVDLAGKEVVVVGRSNIVGKPVALMCLQQHATVTICHSKTRDLPSKVKEADVVIAAVGVPEMIKGEWIKEGAVVIDVGVNRVGEKKLVGDVEFAAASQRASAITPVPGGVGPMTITMLLYNTLEAAKKTGEGNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WJ1</accession>
    <name>Q39WJ1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513409.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1145"/>
    <dbReference type="EnsemblBacteria" id="ABB31383">
        <property type="protein sequence ID" value="ABB31383"/>
        <property type="gene ID" value="Gmet_1145"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1145"/>
    <dbReference type="HOGENOM" id="CLU_868082_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="320" mass="35819" checksum="0ABE149D1609EF91" modified="2005-11-22" version="1">MGMIRIHTTATSPLVGRNNAALSGIHLTPDAAVRRIVRAGAIQAGDYDQLNDGKEAGSPSTVETCRENSAGIRQCLRTPEKRLQRTPGRPSRLVPDLEEATVNDLESYMPMARSDQLRQQMVDAIVSDRQRKGTDFSIMVRGRPVYDSDLWQRAMQQLPAEQRSEPRNGITVHPRTQLNPDPLPLVLIGPTAFGPLIDPSNRDLVRELVVRLYTAITHEYRHATQWQRPAEATAMGRVRLEVDAFFADIENSRATGLAGQREPFRHTWDEAVGWWRQLRAPALWGALSDDERRAYAERCRRVFAVVQSVLGRGVSSPCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WS3</accession>
    <name>Q39WS3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Periplasmically oriented, membrane-bound formate dehydrogenase, cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">fdnI</name>
        <name evidence="8" type="ordered locus">Gmet_1061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NrfD family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513237.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1061"/>
    <dbReference type="EnsemblBacteria" id="ABB31301">
        <property type="protein sequence ID" value="ABB31301"/>
        <property type="gene ID" value="Gmet_1061"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1061"/>
    <dbReference type="eggNOG" id="COG5557">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049007_0_0_7"/>
    <dbReference type="OMA" id="SNDYPWG"/>
    <dbReference type="OrthoDB" id="1903395at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005614">
        <property type="entry name" value="NrfD_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03916">
        <property type="entry name" value="NrfD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="401" mass="44888" checksum="864EFE03110DAA5F" modified="2005-11-22" version="1">MTAARIVMNEIKGYHRFIKFLMVLVGGAALASAVRFIFGLGATTNLNDLYPWGLWISFDVVTAVPLAAGAFTIGIVAHVFHIKKLEPLVRPAIVTGFLGYSLVCVGLLLDLGQPQRGPYVLFNWNVHSPMFEVSMCVMAYTTVLFLEFLHPVSERFGWHIPLRLLRTLELPFAILAAMISTLHQSTLGTFFLIAVDKLHNLWYNPLLPLQFWLSAIFTGLSIVIFEASLVHKYMGQPDESDLLATLTKIIPWIMGVYMLVKVYALASLSHGPLFDRPVLTALFAVEVIVGLLIPFGMFLTKRIRTDKQMQLRAASFVIAGLVLNRFNVSMFAMHQPGQPAYFPNFIESVVTIGIIAAHILFFVLVAKYFPIFEHHPEATDYTIPDRFRKIEKHGHGVASEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WT0</accession>
    <name>Q39WT0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1054</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513228.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1054"/>
    <dbReference type="EnsemblBacteria" id="ABB31294">
        <property type="protein sequence ID" value="ABB31294"/>
        <property type="gene ID" value="Gmet_1054"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1054"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_7"/>
    <dbReference type="OMA" id="HELNSPM"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="332"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="552" mass="62220" checksum="F106B645A3D61A7F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WX0</accession>
    <name>Q39WX0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hemerythrin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1012</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513182.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1012"/>
    <dbReference type="EnsemblBacteria" id="ABB31254">
        <property type="protein sequence ID" value="ABB31254"/>
        <property type="gene ID" value="Gmet_1012"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1012"/>
    <dbReference type="eggNOG" id="COG3945">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095978_2_0_7"/>
    <dbReference type="OMA" id="DICHHGK"/>
    <dbReference type="OrthoDB" id="1701106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012312">
        <property type="entry name" value="Hemerythrin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01814">
        <property type="entry name" value="Hemerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hemerythrin" evidence="1">
        <location>
            <begin position="6"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="180" mass="20349" checksum="25D716CCC581EA70" modified="2005-11-22" version="1">MEKRATQILEEEHHLIQQVVGAMAALADRVFEGQVAEKETLVNLVDFMRVFVEKCHHEKEENHLFPLLVKKGVPVAGCPIGMLTREHQAAGKLTTDLGAAVEAYLKEPSGMGHFLVTTLRGVVALYPGHIWRENYLLFPMTDKILDDREQEGLVEQFETVERKIGLDVHQRFEHLAEKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WY6</accession>
    <name>Q39WY6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter, substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0996</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0996"/>
    <dbReference type="EnsemblBacteria" id="ABB31238">
        <property type="protein sequence ID" value="ABB31238"/>
        <property type="gene ID" value="Gmet_0996"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0996"/>
    <dbReference type="eggNOG" id="COG0715">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028871_10_0_7"/>
    <dbReference type="OMA" id="GPAINTF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13553">
        <property type="entry name" value="PBP2_NrtA_CpmA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010067">
        <property type="entry name" value="ABC_SsuA_sub-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044527">
        <property type="entry name" value="NrtA/CpmA_ABC-bd_dom"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01728">
        <property type="entry name" value="SsuA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="351" mass="38501" checksum="B53511BDA21E661D" modified="2005-11-22" version="1">MAGAIGWEKAIKSGRVWGAFLLCLLLVPWSQSHAGAKRLRLGYFPNITHGQALYARATGELEKMMGVPIEWIPFNAGPSVIEALFVDALDAAFIGPSPTINGYIKSKGEKFVIVAGASSGGAGLVVRKDSGIGGEKDFHGKVIATPQLGNTQDLAARAWFAAKGYRLKETGGTVSLVPLSNPDQLTMFKKKQIDGAWTIEPWLSRLELEGGGRLFLDEKSLWPEGRYVTTHLVVHRKFLAENEELVKKLLTAHVELTQRMNADKVATARLLNGQLKKDTGKELEGEVISRALSRVEFTWDPIAPSMAKLAEIAHRIKFLRTSPRLDGIYELNPLNAVLRQKNLPEVSDGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X42</accession>
    <name>Q39X42_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">glgP</name>
        <name evidence="11" type="ordered locus">Gmet_0940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="function">
        <text evidence="8">Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514423.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0940"/>
    <dbReference type="CAZy" id="GT35">
        <property type="family name" value="Glycosyltransferase Family 35"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31182">
        <property type="protein sequence ID" value="ABB31182"/>
        <property type="gene ID" value="Gmet_0940"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0940"/>
    <dbReference type="eggNOG" id="COG0058">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010198_1_1_7"/>
    <dbReference type="OMA" id="WLQIANP"/>
    <dbReference type="OrthoDB" id="137158at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102250">
        <property type="term" value="F:linear malto-oligosaccharide phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102499">
        <property type="term" value="F:SHG alpha-glucan phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="PTHR11468"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="838" mass="96988" checksum="83E377FE47AC3671" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X60</accession>
    <name>HLDE_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Bifunctional protein HldE</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="1">D-beta-D-heptose 7-phosphate kinase</fullName>
                <ecNumber evidence="1">2.7.1.167</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">D-beta-D-heptose 7-phosphotransferase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="1">D-glycero-beta-D-manno-heptose-7-phosphate kinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="1">D-beta-D-heptose 1-phosphate adenylyltransferase</fullName>
                <ecNumber evidence="1">2.7.7.70</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="1">D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="1" type="primary">hldE</name>
        <name type="ordered locus">Gmet_0922</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate at the C-1 position to selectively form D-glycero-beta-D-manno-heptose-1,7-bisphosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Catalyzes the ADP transfer from ATP to D-glycero-beta-D-manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 7-phosphate = ADP + D-glycero-beta-D-manno-heptose 1,7-bisphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60204"/>
            <dbReference type="ChEBI" id="CHEBI:60208"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.167"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-D-glycero-beta-D-manno-heptose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:27465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:59967"/>
            <dbReference type="ChEBI" id="CHEBI:61593"/>
            <dbReference type="EC" id="2.7.7.70"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; ADP-L-glycero-beta-D-manno-heptose biosynthesis; ADP-L-glycero-beta-D-manno-heptose from D-glycero-beta-D-manno-heptose 7-phosphate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the cytidylyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.167" evidence="1"/>
    <dbReference type="EC" id="2.7.7.70" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513952.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X60"/>
    <dbReference type="SMR" id="Q39X60"/>
    <dbReference type="STRING" id="269799.Gmet_0922"/>
    <dbReference type="EnsemblBacteria" id="ABB31164">
        <property type="protein sequence ID" value="ABB31164"/>
        <property type="gene ID" value="Gmet_0922"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0922"/>
    <dbReference type="eggNOG" id="COG0615">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2870">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021150_2_1_7"/>
    <dbReference type="OMA" id="CEFANAA"/>
    <dbReference type="OrthoDB" id="1030724at2"/>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00437"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00356">
        <property type="reaction ID" value="UER00439"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033785">
        <property type="term" value="F:heptose 7-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033786">
        <property type="term" value="F:heptose-1-phosphate adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097171">
        <property type="term" value="P:ADP-L-glycero-beta-D-manno-heptose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01172">
        <property type="entry name" value="RfaE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01603">
        <property type="entry name" value="HldE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023030">
        <property type="entry name" value="Bifunc_HldE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011913">
        <property type="entry name" value="RfaE_dom_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011914">
        <property type="entry name" value="RfaE_dom_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="SSF53613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02198">
        <property type="entry name" value="rfaE_dom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02199">
        <property type="entry name" value="rfaE_dom_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00583">
        <property type="entry name" value="PFKB_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword id="KW-0418">Kinase</keyword>
    <keyword id="KW-0511">Multifunctional enzyme</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000255759" description="Bifunctional protein HldE">
        <location>
            <begin position="1"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Ribokinase">
        <location>
            <begin position="1"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Cytidylyltransferase">
        <location>
            <begin position="356"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="205"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01603"/>
        </source>
    </evidence>
    <sequence length="490" mass="52331" checksum="B8CA2F4A915C6A4A" modified="2005-11-22" version="1">MERKNVESLFAHARDINALVIGDLMLDEYLWGRAERISPEAPVQVLDVTREEVRIGGAGNVANNLVALGCRVSVASVVGGDENGTILLHAFSGKGVDVSGVFEDPQRTTSRKTRVVAANQQIVRIDRESRDPIGAGYEEKIVGFLREQGSRFNVILISDYLKGVLTPTLLAAVIAVARERKIPVVVDPKGNDYTKYRGATLLTPNRKEAEAASGIAIRDEASLCRAGERLLATADLTALVITRSEEGMSLFLRDGGVVHIPTFAREVFDVTGAGDTVLAILGLALACGVGFADAAGLANVAAGIAVGKVGTSTVSPAEVIGSMGFQHSDSDAKIKNLDGLAGIIEAEKARGKKIVFTNGCFDLLHVGHVKYLQKAKSYGDVLVLGLNSDASVRRLKGEKRPLIDEAERAHILAALDCIDYVVIFDEDTPLRLIETLKPAVLVKGGDYTPEGVVGKDVVESYGGRVELVTFVDGRSTTNIIDKILRAYGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X79</accession>
    <name>Q39X79_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 10">Carboxynorspermidine/carboxyspermidine decarboxylase</fullName>
            <shortName evidence="10">CANS DC/CAS DC</shortName>
            <shortName evidence="10">CANSDC/CASDC</shortName>
            <ecNumber evidence="6 10">4.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nspC</name>
        <name evidence="13" type="ordered locus">Gmet_0903</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the decarboxylation of carboxynorspermidine and carboxyspermidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 10">
            <text>carboxynorspermidine + H(+) = CO2 + norspermidine</text>
            <dbReference type="Rhea" id="RHEA:34099"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57920"/>
            <dbReference type="ChEBI" id="CHEBI:65070"/>
            <dbReference type="EC" id="4.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>carboxyspermidine + H(+) = CO2 + spermidine</text>
            <dbReference type="Rhea" id="RHEA:34095"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:65072"/>
            <dbReference type="EC" id="4.1.1.96"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.96" evidence="6 10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513933.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0903"/>
    <dbReference type="EnsemblBacteria" id="ABB31145">
        <property type="protein sequence ID" value="ABB31145"/>
        <property type="gene ID" value="Gmet_0903"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0903"/>
    <dbReference type="eggNOG" id="COG0019">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038560_0_0_7"/>
    <dbReference type="OMA" id="YTMVKTT"/>
    <dbReference type="OrthoDB" id="861683at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045312">
        <property type="term" value="P:nor-spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06829">
        <property type="entry name" value="PLPDE_III_CANSDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005730">
        <property type="entry name" value="Nsp_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43727:SF1">
        <property type="entry name" value="PTHR43727:SF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038941">
        <property type="entry name" value="NspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="SSF50621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01047">
        <property type="entry name" value="nspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0745">Spermidine biosynthesis</keyword>
    <feature type="domain" description="Orn_DAP_Arg_deC" evidence="12">
        <location>
            <begin position="95"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR038941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038941-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="384" mass="42807" checksum="DE3D6F5747BD7055" modified="2005-11-22" version="1">MTGIDIEKILKLAPSPAYVVDLGRLRHNLAILDDVQKRSGAKILMALKAFAMWSVFPIIRETLQGVCASSPWEARLGREEFGREVHSFAAAFKESDVVELLAVSNHLVFNSFNQLERFRPLWEKERGRVSVGLRVNPEHSEGHTPIYDPCAPKSRLGIPRAAFEGKSLAGVEGLHFHTLCEQLFEPLERTAKVFEEKFGPLLHGMKWLNLGGGHHITRAGYDIDALVELVKYFKGKYGVEVYLEPGEAIAIGTGVLVGEVLDVVRNEMEIAILDVSATCHMPDVLEMPYRPGITGGFDPGEKAHTYRLAGPSCLAGDVIGDWSFDKPLKPGDRLVFEDMSHYTMVKTTTFNGIQHPAICTFEPETGELRVVRRFGYEDFKSRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X95</accession>
    <name>Q39X95_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Undecaprenyl-diphospho-4-amino-4-deoxy-L-arabinose--lipid A 4-amino-4-deoxy-L-arabinose transferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">arnT</name>
        <name evidence="11" type="ordered locus">Gmet_0887</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513034.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0887"/>
    <dbReference type="CAZy" id="GT83">
        <property type="family name" value="Glycosyltransferase Family 83"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31129">
        <property type="protein sequence ID" value="ABB31129"/>
        <property type="gene ID" value="Gmet_0887"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0887"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019200_0_0_7"/>
    <dbReference type="OMA" id="GHSAPWY"/>
    <dbReference type="OrthoDB" id="854536at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040845">
        <property type="entry name" value="Arnt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18583">
        <property type="entry name" value="Arnt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="73"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Arnt_C" evidence="10">
        <location>
            <begin position="450"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="554" mass="61867" checksum="E47A279E45AAD44C" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XE2</accession>
    <name>Q39XE2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Diguanylate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512984.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0840"/>
    <dbReference type="EnsemblBacteria" id="ABB31082">
        <property type="protein sequence ID" value="ABB31082"/>
        <property type="gene ID" value="Gmet_0840"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0840"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054734_1_0_7"/>
    <dbReference type="OMA" id="TIADYQM"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="3">
        <location>
            <begin position="261"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="411" mass="45039" checksum="AC6CC05A15EEB4AA" modified="2005-11-22" version="1">MHALSMKNLTIFLIPAAFLTATIWFFPQVATLPPGRLELLPFIPYLTMALGMMLSFHFHRGRAFFVFLVLIAVYWSFRGHLNGAPTGITATVLFQSVCVLVPLNIALFSLMRERGIMTVAGRLRFAFLALQALFVGWAMEPGHVAVQQLLSCRFTESHLLAGLQLPQPALPVIVLGTAVVIGRAARGQSPIDASLLGVMAAFVVACNGIGTEFVTPVFMAAAAAILTLGVLKDSYNMAFRDELTGLPSRRALNEQLTWLGRRYTVAMVDVDHFKRFNDTYGHDVGDQVLRMVASKLRGVGGGGKVYRYGGEEFTILFHRKEREEVLADLEGLRRTIADYQMRLRGTDRPSSSKEGKKLRYGTGRGNATVSVTVSIGVAESSADRRRPADVIKAADQALYRAKGGGRNRVCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XI4</accession>
    <name>Q39XI4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transporter, RhtB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513543.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0798"/>
    <dbReference type="EnsemblBacteria" id="ABB31040">
        <property type="protein sequence ID" value="ABB31040"/>
        <property type="gene ID" value="Gmet_0798"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0798"/>
    <dbReference type="eggNOG" id="COG1280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_079569_3_2_7"/>
    <dbReference type="OMA" id="KMGWDCM"/>
    <dbReference type="OrthoDB" id="1927576at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001123">
        <property type="entry name" value="LeuE-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30086">
        <property type="entry name" value="PTHR30086"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01810">
        <property type="entry name" value="LysE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006324">
        <property type="entry name" value="LeuE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="63"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="206" mass="21999" checksum="610183F473E7EADE" modified="2005-11-22" version="1">MTLYTLLCFLGASIALTVAPGPDNIFVMTQGVARGRKPAIVTALGMCSGVTVHTTAAAFGISAVFYSSAIAFTVVKSAGAAYLLYLAFKTLKERSAIRLSAADDLPAAALFRRGFIMNVLNPKVAMFFLAFLPQFVAPAAGRVPLQMLLLGLIFMVQSVVIFCLLGYFAGSIGSFILARPRIARYFDWLTAGVFLSLGVRLALAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XM7</accession>
    <name>Q39XM7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30997.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0755"/>
    <dbReference type="EnsemblBacteria" id="ABB30997">
        <property type="protein sequence ID" value="ABB30997"/>
        <property type="gene ID" value="Gmet_0755"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0755"/>
    <dbReference type="eggNOG" id="COG2888">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1924556_0_0_7"/>
    <dbReference type="OMA" id="LHRAIAF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30997.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="238" mass="25818" checksum="5067124D4A61B963" modified="2012-10-31" version="2">MTVSCPQCGASVEARTETRFHHCPFCTSSFVAEEGRGIVEYYLAHSRDDRLAWSTLASTLEGGGDDSPVERLGCEYLVAPFWLSRSGGGTRLVPALRHPWFGMASLVLPGGDLLYVPKGSDFTPPDIPVAEAWGDGAGREPGSLALVHLPLYLLTFRVGGSDCRAVVSAVDRRAYLLDPLPRSAVTLPLRHVALVVGYSLLLVIVGMAVKNHLHRAIAFAIIFGMAYFSFNAFLRREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XN5</accession>
    <name>Q39XN5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaA regulatory inactivator Hda</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hda</name>
        <name evidence="4" type="ordered locus">Gmet_0747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the DnaA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514464.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0747"/>
    <dbReference type="DNASU" id="3739885"/>
    <dbReference type="EnsemblBacteria" id="ABB30989">
        <property type="protein sequence ID" value="ABB30989"/>
        <property type="gene ID" value="Gmet_0747"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0747"/>
    <dbReference type="eggNOG" id="COG0593">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072265_1_0_7"/>
    <dbReference type="OMA" id="DWGQIYR"/>
    <dbReference type="OrthoDB" id="1110566at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001957">
        <property type="entry name" value="Chromosome_initiator_DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020591">
        <property type="entry name" value="Chromosome_initiator_DnaA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013317">
        <property type="entry name" value="DnaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30050:SF2">
        <property type="entry name" value="PTHR30050:SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00308">
        <property type="entry name" value="Bac_DnaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00051">
        <property type="entry name" value="DNAA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="3">
        <location>
            <begin position="40"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="243" mass="27242" checksum="DC7479795AA0A1FF" modified="2005-11-22" version="1">MQLVFDFPVNPKYSLDNFVICSGNETAYRFVRRLTDDEGAENLLYLHGPSGSGKTHLLMAIGAHFSARAGLSSVPCISFKDVDEVYGGEYPAEAVSKLAERFRNAPALLVDDLHLIPDQQAVRVELWQLFNDFYQAGRPIAITGLYPPKELPTIDDHLISRLLWGLVARVDISDDDSRRLIMKKLADDRQIVLPADVIDYLLLHVRRDVPSLIEALDAISRYALAAKRKVSVRLAREALAFHS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y03</accession>
    <name>RL2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplB</name>
        <name type="ordered locus">Gmet_0629</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y03"/>
    <dbReference type="SMR" id="Q39Y03"/>
    <dbReference type="STRING" id="269799.Gmet_0629"/>
    <dbReference type="EnsemblBacteria" id="ABB30871">
        <property type="protein sequence ID" value="ABB30871"/>
        <property type="gene ID" value="Gmet_0629"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0629"/>
    <dbReference type="eggNOG" id="COG0090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036235_2_1_7"/>
    <dbReference type="OMA" id="SCIELRP"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01320_B">
        <property type="entry name" value="Ribosomal_L2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Rbsml_prot_L2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_L2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005880">
        <property type="entry name" value="Ribosomal_L2_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_L2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_L2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_L2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="PTHR13691"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="SSF50104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01171">
        <property type="entry name" value="rplB_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000237190" description="50S ribosomal protein L2">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="274" mass="29902" checksum="6D01FE0F933A6BBA" modified="2005-11-22" version="1">MAIKTYKPTSAGRRHQTCSAFDEITTSSPEKSLLLTLKKTGGRNSFGRITSRHIGGGHKKKYRLVDFRRNKIDIPAKVASIEYDPNRSARIALLHYSDGEKRYILAPLNLKVGDVVLASTSADIKPGNSLPLRAIPLGTIIHNIELKIGKGGQLARSAGTFAQLMAKEGKYAQVKLPSGEVRMVLLDCMATVGQVGNIDHENVTIGKAGRSRWLGRRPKVRGVAMNPVDHPHGGGEGRTSGGRHPVTPWGIPTKGYKTRKNKTSSRFIVKPRTK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y23</accession>
    <name>ARGC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyl-gamma-glutamyl-phosphate reductase</fullName>
            <shortName evidence="1">AGPR</shortName>
            <ecNumber evidence="1">1.2.1.38</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N-acetyl-glutamate semialdehyde dehydrogenase</fullName>
            <shortName evidence="1">NAGSA dehydrogenase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argC</name>
        <name type="ordered locus">Gmet_0608</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N-acetyl-L-glutamate 5-semialdehyde + NADP(+) + phosphate = H(+) + N-acetyl-L-glutamyl 5-phosphate + NADPH</text>
            <dbReference type="Rhea" id="RHEA:21588"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.38"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.38" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514738.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y23"/>
    <dbReference type="SMR" id="Q39Y23"/>
    <dbReference type="STRING" id="269799.Gmet_0608"/>
    <dbReference type="EnsemblBacteria" id="ABB30851">
        <property type="protein sequence ID" value="ABB30851"/>
        <property type="gene ID" value="Gmet_0608"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0608"/>
    <dbReference type="eggNOG" id="COG0002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006384_0_1_7"/>
    <dbReference type="OMA" id="PHLTPMI"/>
    <dbReference type="OrthoDB" id="951261at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00108"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012280">
        <property type="entry name" value="Semialdhyde_DH_dimer_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02774">
        <property type="entry name" value="Semialdhyde_dhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000010996" description="N-acetyl-gamma-glutamyl-phosphate reductase">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00150"/>
        </source>
    </evidence>
    <sequence length="346" mass="37483" checksum="A9258107FAFD2C86" modified="2005-11-22" version="1">MLNVAVVGASGYTGVELLRLLYCHPEVAVTCITSEQSAGRPVAAVFPTLRSRYTQVLENLEPVKVAQKADLIFTALPHKAAMEVVPTFLELGKRVVDLSADYRFNDPAVYEKWYEPHMNPENLKEAVYGLPEIRREKIGDAWLVGNPGCYPTSVILGLMPLLKKRLIDPSTIIADSKSGVSGAGRGAKVENLYCEVNDGFKAYGVGGVHRHIPEIEQELSLLAGGPITITFTPHLVPMDRGILSTIYARLTGTDSVAELVKLYAEFYEGEPFVRVLPAGNVPSTAHVRGSNFCDIGLAVDSRTGRVIVVSAIDNLVKGAAGQAVQNMNIMYGFPETMGLEGLPLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y77</accession>
    <name>Q39Y77_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0554</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365683.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0554"/>
    <dbReference type="EnsemblBacteria" id="ABB30797">
        <property type="protein sequence ID" value="ABB30797"/>
        <property type="gene ID" value="Gmet_0554"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0554"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_29_7"/>
    <dbReference type="OMA" id="VRIFHPH"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="200"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="277"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="499" mass="54647" checksum="3D00D8B218C1684C" modified="2005-11-22" version="1">MIFKSLTTRVIVTLVGLLSVGIGTFTYFNLKREKDQLVKATRENAYLLLDTIERSIYKSMSVGDTQDVQVMLQMVGHSHSKLIGVRIFHPQGIVLKSSRPEEVGMPVPEGDYQLFINNRKEGVYSSDAFGEVLGVIKPIYNDVLCQRCHGTKKRLIGVLNVNYSQVETNRRILEATRLSLVSTGAVILFCAAAISLVIVRFVRQPLNNLIDSMARVEEGDLSVRITPVAEDEIGRLIVSFDSMVGKLDKAKRELEEYHFQQMERADRLASVGEMAAGIAHEIKNPLAGISAAMTIIRQDFSDEDPRKEIIGEVVEQVSRLDKTVNDLLFFGKPTPPEPTYADVNAILRKTLLFALQHKGGKNIAKSLDLADGLPEIFVDPKQVQQVFLNLILNAIQAMQADGGTLTVGSSLVDLDGKGWVRTTIADTGPGIPEPIIGKIFTPFFTTKAQGTGLGLAICHKLITQHGGTLSVTSEDGKGTVFTIDLPVAAYEEGAPEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YD2</accession>
    <name>Q39YD2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512195.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0499"/>
    <dbReference type="EnsemblBacteria" id="ABB30742">
        <property type="protein sequence ID" value="ABB30742"/>
        <property type="gene ID" value="Gmet_0499"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0499"/>
    <dbReference type="eggNOG" id="COG4771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5628">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1473178_0_0_7"/>
    <dbReference type="OrthoDB" id="2055010at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223309" evidence="1">
        <location>
            <begin position="30"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="183" mass="20590" checksum="3C9F593E49FF1946" modified="2005-11-22" version="1">MVFPHFFRIPCSCLLLCALSLAAGPSAHGEEVTEEKLKAIYNRAFRAPTIEQTSAVLKTGNKLKTATADVLELEANHRFDARSHATVSLFDIRMNHPINYYYDFVNSLDAHKNEGRIGTQRVEAEHQFRGTWEVNQIAGADNAKAFWRRAIGSYTGGAYRDDVYSDPYWGTVTRQQFRNGGEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YM1</accession>
    <name>MURD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UDP-N-acetylmuramoylalanine--D-glutamate ligase</fullName>
            <ecNumber evidence="1">6.3.2.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">D-glutamic acid-adding enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">murD</name>
        <name type="ordered locus">Gmet_0410</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + D-glutamate + UDP-N-acetyl-alpha-D-muramoyl-L-alanine = ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16429"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29986"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83898"/>
            <dbReference type="ChEBI" id="CHEBI:83900"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cell wall biogenesis; peptidoglycan biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MurCDEF family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512382.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YM1"/>
    <dbReference type="SMR" id="Q39YM1"/>
    <dbReference type="STRING" id="269799.Gmet_0410"/>
    <dbReference type="EnsemblBacteria" id="ABB30653">
        <property type="protein sequence ID" value="ABB30653"/>
        <property type="gene ID" value="Gmet_0410"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0410"/>
    <dbReference type="eggNOG" id="COG0771">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032540_0_0_7"/>
    <dbReference type="OMA" id="CNFENYL"/>
    <dbReference type="OrthoDB" id="1093223at2"/>
    <dbReference type="UniPathway" id="UPA00219"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008764">
        <property type="term" value="F:UDP-N-acetylmuramoylalanine-D-glutamate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00639">
        <property type="entry name" value="MurD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005762">
        <property type="entry name" value="MurD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="SSF53244"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="SSF53623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01087">
        <property type="entry name" value="murD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0131">Cell cycle</keyword>
    <keyword id="KW-0132">Cell division</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000257193" description="UDP-N-acetylmuramoylalanine--D-glutamate ligase">
        <location>
            <begin position="1"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="115"/>
            <end position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00639"/>
        </source>
    </evidence>
    <sequence length="452" mass="49050" checksum="9F78891DBCAA3EBE" modified="2005-11-22" version="1">MEISGKNILVVGLARTGVAVARFLARNGARVTVTDLRDESALAGPLRELAGLSVRYVLDRHDEADFAAADVVVVSPGVPQESPYLQAARRAGREVITEIELASRFVTVPMVAITGTNGKTTTTTLTGEIFSACGFRTFVGGNIGNPLIELVEGGETVERVVVEISSFQLEWISSFRPRVAVLLNITEDHLDRYATFQEYIDAKVRIFENQESTDYAVLNVDDPIVAGIAGRVAATVFPMSQQRELAEGVFHRDGVITFRHQGREERFPTARFRITGVHNIENIMASLAATLLLGCDAKQALAAVEGFGGLPHRMELVRELAGVRYYEDSKATNVGSVEKALASFNDITLIAGGKDKGGSYAPLAPLVTERVRHMVLIGEAKERMARELGSLTDTRMATTLEEAVELAASLTEPGGVVLFSPACSSFDMFRDYEERAQRFRAAVNALGTGERP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YQ3</accession>
    <name>Q39YQ3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flavin-dependent thymidylate synthase</fullName>
            <shortName evidence="1">FDTS</shortName>
            <ecNumber evidence="1">2.1.1.148</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">FAD-dependent thymidylate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Thymidylate synthase ThyX</fullName>
            <shortName evidence="1">TS</shortName>
            <shortName evidence="1">TSase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1 2" type="primary">thyX</name>
        <name evidence="2" type="ordered locus">Gmet_0378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + dUMP + H(+) + NADPH = (6S)-5,6,7,8-tetrahydrofolate + dTMP + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:29043"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.148"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="1">Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the thymidylate synthase ThyX family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.148" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512350.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0378"/>
    <dbReference type="EnsemblBacteria" id="ABB30621">
        <property type="protein sequence ID" value="ABB30621"/>
        <property type="gene ID" value="Gmet_0378"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0378"/>
    <dbReference type="eggNOG" id="COG1351">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_077585_0_0_7"/>
    <dbReference type="OMA" id="AKLGPRC"/>
    <dbReference type="OrthoDB" id="896350at2"/>
    <dbReference type="UniPathway" id="UPA00575"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050797">
        <property type="term" value="F:thymidylate synthase (FAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01408">
        <property type="entry name" value="ThyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003669">
        <property type="entry name" value="Thymidylate_synthase_ThyX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036098">
        <property type="entry name" value="Thymidylate_synthase_ThyX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34934">
        <property type="entry name" value="PTHR34934"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02511">
        <property type="entry name" value="Thy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69796">
        <property type="entry name" value="SSF69796"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02170">
        <property type="entry name" value="thyX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51331">
        <property type="entry name" value="THYX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Involved in ionization of N3 of dUMP, leading to its activation" evidence="1">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="79"/>
            <end position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="87"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="158"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <note>ligand shared between neighboring subunits</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>dUMP</name>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="231" mass="25807" checksum="BE17BF222780FBC9" modified="2005-11-22" version="1">MKVTLLQHTPDPEMAVALAARLCYSPIGIDELKERLSRSDISAFLDKIMSLGHQSVLEHASFTFGIEGISRATSHQLVRHRIASYSQQSQRYVTHTEQFSAVIPPSIAGRPDLAARFRSQLKALHDTYAELFEAGIPAEDARYILPNAAETKIIMTMNARELLHFFGLRCCERAQWEIRAMAVEMLRLVKGVAPTIFRDAGPGCVAGPCPEGTMTCGKIVEVRKRFKEMYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YT1</accession>
    <name>Q39YT1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0350</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512321.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0350"/>
    <dbReference type="EnsemblBacteria" id="ABB30593">
        <property type="protein sequence ID" value="ABB30593"/>
        <property type="gene ID" value="Gmet_0350"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0350"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_72_7"/>
    <dbReference type="OMA" id="MDIIMPV"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="140"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="267"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="482" mass="54881" checksum="F501BC68FB9CC2A7" modified="2005-11-22" version="1">MDHQLRMLILEDSEDDLLLLLRELRRGGIDPVYERTETDAGMRALLDEREWDVIIADYNMPRFGAMVGLEIVKERELDIPFIIVSGKIGEDLAVAAMKAGAHDYLMKGNLSRLVPAIEREVREAGERRRRRQAEAAMRNQFNQISTIFDSLNALVYVVDMDSYRLLYLNKYGAQLFGENWEGRPCHEVIQGGKTLPCDFCTNDKLLLDGKALPPYIWEYKNMTTGRWYQCIDKAIRWTDDRLVRMEIAIDITERKEMERMKDEMISAVSHEMHTPLTAMIGFTEFLLENEVDREQQKNCLQTIHKETERLSELINNFLQLQRLKASMVKFRIMPVSVGLLLADAAALYTAASRKHTIVVECPPDLPPVRGNEEQLYQVAGNLISNAIKYSPAGGTVTLGGRADDDMVVFWVKDNGVGISPEFQERVFERFFRVDNSDRRKVGGAGLGLTLVREIVAAHGGRVWVESTPDAGSTFFVSLPRMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YW5</accession>
    <name>Q39YW5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514026.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0315"/>
    <dbReference type="EnsemblBacteria" id="ABB30559">
        <property type="protein sequence ID" value="ABB30559"/>
        <property type="gene ID" value="Gmet_0315"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0315"/>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066192_18_0_7"/>
    <dbReference type="OMA" id="HALGCRL"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="36"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="117" mass="12844" checksum="BE964C261F4B15A7" modified="2005-11-22" version="1">MLTHKKLKARALERPDVKAEYDRLDEEFAFLDEFLKARAAAGVTQAEVAERIGTTQSAIARLESGGGKHSPSLATLQKYAHALGCRLELRLVQETKAREIEGRASRPSRAATKRVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z63</accession>
    <name>Q39Z63_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0215</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512804.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0215"/>
    <dbReference type="EnsemblBacteria" id="ABB30461">
        <property type="protein sequence ID" value="ABB30461"/>
        <property type="gene ID" value="Gmet_0215"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0215"/>
    <dbReference type="eggNOG" id="COG4190">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_130787_1_1_7"/>
    <dbReference type="OMA" id="RIDHGER"/>
    <dbReference type="OrthoDB" id="1887301at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="120" mass="14157" checksum="8AAF77113493CA1C" modified="2005-11-22" version="1">MKRDIKVGIKSDDEFFAEAREFARKLDTGWRPEQPVESLYFEDLPTLLKYLTPKRFELLNTLHSVGHVSINALAKKLHRQYRNVFDDVKTLERLGLVEKDEESRFFVPWDEIDATFRLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZE2</accession>
    <name>Q39ZE2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Polyphosphate kinase</fullName>
            <ecNumber evidence="6 7">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-polyphosphate phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Polyphosphoric acid kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 13" type="primary">ppk</name>
        <name evidence="13" type="ordered locus">Gmet_0133</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 7">Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="6 7">An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the polyphosphate kinase 1 (PPK1) family.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="6 7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512718.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0133"/>
    <dbReference type="EnsemblBacteria" id="ABB30382">
        <property type="protein sequence ID" value="ABB30382"/>
        <property type="gene ID" value="Gmet_0133"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0133"/>
    <dbReference type="eggNOG" id="COG0855">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009678_5_0_7"/>
    <dbReference type="OMA" id="NIKWARK"/>
    <dbReference type="OrthoDB" id="76567at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009358">
        <property type="term" value="C:polyphosphate kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1840.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00347">
        <property type="entry name" value="Polyphosphate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003414">
        <property type="entry name" value="PP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041108">
        <property type="entry name" value="PP_kinase_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024953">
        <property type="entry name" value="PP_kinase_middle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036830">
        <property type="entry name" value="PP_kinase_middle_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025200">
        <property type="entry name" value="PPK_C_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025198">
        <property type="entry name" value="PPK_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036832">
        <property type="entry name" value="PPK_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30218">
        <property type="entry name" value="PTHR30218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02503">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13090">
        <property type="entry name" value="PP_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17941">
        <property type="entry name" value="PP_kinase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13089">
        <property type="entry name" value="PP_kinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015589">
        <property type="entry name" value="PP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140356">
        <property type="entry name" value="SSF140356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03705">
        <property type="entry name" value="poly_P_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 6 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PP_kinase_N" evidence="10">
        <location>
            <begin position="32"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase" evidence="9">
        <location>
            <begin position="146"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C_1" evidence="12">
        <location>
            <begin position="350"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="PP_kinase_C" evidence="11">
        <location>
            <begin position="525"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="709"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphohistidine intermediate" evidence="6">
        <location>
            <position position="456"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="586"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB30382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="728" mass="82396" checksum="B5659DBB810FD7A1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZF5</accession>
    <name>Q39ZF5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hydrogenase accessory protein HypB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hypB</name>
        <name evidence="3" type="ordered locus">Gmet_0120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514125.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0120"/>
    <dbReference type="EnsemblBacteria" id="ABB30369">
        <property type="protein sequence ID" value="ABB30369"/>
        <property type="gene ID" value="Gmet_0120"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0120"/>
    <dbReference type="eggNOG" id="COG0378">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056148_0_0_7"/>
    <dbReference type="OMA" id="ECHLDAH"/>
    <dbReference type="OrthoDB" id="1134430at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05390">
        <property type="entry name" value="HypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004392">
        <property type="entry name" value="Hyd_mat_HypB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30134">
        <property type="entry name" value="PTHR30134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00073">
        <property type="entry name" value="hypB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="cobW" evidence="2">
        <location>
            <begin position="58"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="244" mass="26720" checksum="308F9BD4AE60E2FF" modified="2005-11-22" version="1">MCTTCGCETDTHHHHHHHHHGEGKEARKIAVELDILARNNRFAAENRALFAAKGIFALNFVSSPGSGKTTTLERTLKDLAGRYRCAVIEGDQQTDNDAVRIAATGVPVKQINTGAGCHLDAHMVGHAVEEFDLDALDLLLVENVGNLVCPASFDLGEHHKVVVLSVTEGEDKPLKYPNMFHAADVMLLNKVDLLPYVDFDVEKCKEMARRVSPDIAIFEISSRTGEGMDAWYGWLAGRIAAVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZH7</accession>
    <name>Q39ZH7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S4 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514103.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0098"/>
    <dbReference type="EnsemblBacteria" id="ABB30347">
        <property type="protein sequence ID" value="ABB30347"/>
        <property type="gene ID" value="Gmet_0098"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0098"/>
    <dbReference type="eggNOG" id="COG2501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127162_4_0_7"/>
    <dbReference type="OMA" id="DQFLKWA"/>
    <dbReference type="OrthoDB" id="2071059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014330">
        <property type="entry name" value="RNA-bd_S4-rel_YaaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02988">
        <property type="entry name" value="YaaA_near_RecF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="65" mass="7116" checksum="7C4FA3D0CE8F29D5" modified="2005-11-22" version="1">MKIETEYIKLDSFLKAENIVASGGEAKIIIADGEVRVNGEVETRRGRKLRVGDRVEAGGETLVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZN1</accession>
    <name>Q39ZN1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513810.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0043"/>
    <dbReference type="EnsemblBacteria" id="ABB30293">
        <property type="protein sequence ID" value="ABB30293"/>
        <property type="gene ID" value="Gmet_0043"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0043"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_467530_0_0_7"/>
    <dbReference type="OMA" id="TSDEHER"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="47"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="279"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="7">
        <location>
            <begin position="445"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="580" mass="63857" checksum="AF3E4E9681AB63A9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-08-03" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZR6</accession>
    <name>GPDA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycerol-3-phosphate dehydrogenase [NAD(P)+]</fullName>
            <ecNumber evidence="1">1.1.1.94</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">NAD(P)H-dependent glycerol-3-phosphate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gpsA</name>
        <name type="ordered locus">Gmet_0008</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADH</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NADP(+) + sn-glycerol 3-phosphate = dihydroxyacetone phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:11096"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.94"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Membrane lipid metabolism; glycerophospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.94" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513773.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZR6"/>
    <dbReference type="SMR" id="Q39ZR6"/>
    <dbReference type="STRING" id="269799.Gmet_0008"/>
    <dbReference type="PRIDE" id="Q39ZR6"/>
    <dbReference type="EnsemblBacteria" id="ABB30258">
        <property type="protein sequence ID" value="ABB30258"/>
        <property type="gene ID" value="Gmet_0008"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0008"/>
    <dbReference type="eggNOG" id="COG0240">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033449_0_2_7"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="1419877at2"/>
    <dbReference type="UniPathway" id="UPA00940"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009331">
        <property type="term" value="C:glycerol-3-phosphate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004367">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase [NAD+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006650">
        <property type="term" value="P:glycerophospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00394">
        <property type="entry name" value="NAD_Glyc3P_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="SSF48179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword id="KW-1208">Phospholipid metabolism</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000255316" description="Glycerol-3-phosphate dehydrogenase [NAD(P)+]">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00394"/>
        </source>
    </evidence>
    <sequence length="335" mass="35175" checksum="C2E212229F2D2347" modified="2005-11-22" version="1">MGEKIGVIGAGSWGTTLANLLAKKGLDVTLWAYEPELVAEMRATRVNTLFLPGTELAAGLAFTNSLEEAAAGKDVLVLVSPSQVMRSVLTQLAPLLKPGVTLVNASKGIELDTLMTMDQVCGAVLPPAVAGRFCVLSGPSFAREVAQEMPTAVVAASADLEAAAQVQRLFTAPYFRVYTNSDVVGVEIGGALKNVIALAAGISDGLGLGHNTRAALITRGLAEMNRLGRAMGADPATFAGLAGMGDLVLTCTGDLSRNRTVGMKLGQGMRLAEILGEMRMVAEGVKTAESAWRLASQMGVDMPITEKVYQVLYEDKPARQAVLELMTRDPKAERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-06-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEP0</accession>
    <name>J9JEP0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3623"/>
    <dbReference type="EnsemblBacteria" id="AFR42841">
        <property type="protein sequence ID" value="AFR42841"/>
        <property type="gene ID" value="Gmet_3623"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3623"/>
    <dbReference type="HOGENOM" id="CLU_2972995_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="58" mass="6666" checksum="27BA2953782E506F" modified="2012-10-31" version="1">MLVVLFYFVTTLCWHYEPAVTRSISEMLTHSREDGSKSQERRTVTTPIGSTNQFVKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PP6</accession>
    <name>Q39PP6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conjugal transfer protein TrbL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_A3573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="8">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="8">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="8">pGS-15</plasmid>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011363044.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3573"/>
    <dbReference type="EnsemblBacteria" id="ABB33778">
        <property type="protein sequence ID" value="ABB33778"/>
        <property type="gene ID" value="Gmet_A3573"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3573"/>
    <dbReference type="eggNOG" id="COG3846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_564702_0_0_7"/>
    <dbReference type="OMA" id="DHATEWG"/>
    <dbReference type="OrthoDB" id="1236090at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030255">
        <property type="term" value="P:protein secretion by the type IV secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014150">
        <property type="entry name" value="Conjugal_tfr_TrbL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007688">
        <property type="entry name" value="Conjugal_tfr_TrbL/VirB6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04610">
        <property type="entry name" value="TrbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02783">
        <property type="entry name" value="TrbL_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0614">Plasmid</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="351"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="388"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="483" mass="46939" checksum="C52EAC86973FAAE5" modified="2005-11-22" version="1">MATATPDVQILTQVLETFNSVFGTGKGALLSWAMYIAGALAVIEMVLLGAFHALKGGEDNIIPPLVKKILTIGFFIFLVQGVARSGLAEIILDGFIAVGLKAGGAGVSFSMKNPSSLISAGFLAADPIYDAIQHMAITAIGDRLMAYGCYLIVILAYVVMACQIMITFIEFGIVSTLGIILLPFGISKHTAFLSEKAIGAIIAFGIKLMVLSFVVAVIQPVLLALPALGPDPTFNQMMTLGVTVAVIAFVVAQAPGVASAVLSGSPSLSAGAAAGTALSAAAGAAAPAMAAAGMATGGAAVAGGLAGAKAAAAAGNGSFLGNVARAAAGAMPGASAFQAAKSGAISAAEAGSAGGIKPASGGSSLKPAADAAAKGAADTGKTEATPTPAPAADTTATTTDATPPATGSADTTATDAGKTEPAPTTGTGGGTSSLQGSNVGSGGGNGKGQPRRSSLQDAWQQSQRAVPQDASAGGGAGVRLHVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PR9</accession>
    <name>Q39PR9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ-related molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513706.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3550"/>
    <dbReference type="EnsemblBacteria" id="ABB33755">
        <property type="protein sequence ID" value="ABB33755"/>
        <property type="gene ID" value="Gmet_3550"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3550"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017633_0_0_7"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="1738789at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="SSF46565"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="SSF49493"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="5"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="298" mass="32595" checksum="020D7A4780F4BB77" modified="2005-11-22" version="1">MAQTDYYEVLGLKKGATEAEIKKAYRKLAVKYHPDKNPGDKGAEDKFKEINEAYAVLSDPQKRAQYDQFGSSGFHQRYSQEDIFRGFDVGDIFKDMGFGTDDIFSRIFGGAGGFRQGGFGFGGGRRRGEDFTMEVPVTFRESYDGGEKRVAFMRDGKREELAVKIPAGVEDGARLRVAGKGGFGHGGGPTGDLYLIIKVGTDPHFTREGDDIVVERKIRFTDALLGASLDVPTLEGTKRIKIPAGIQPGTKIRLKGLGFPRMGKAGKGDLFVRIGVSVPESLTPEQKTLVEELRGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PY5</accession>
    <name>Q39PY5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FAD-dependent pyridine nucleotide-disulfide oxidoreductase family protein, rhodanese homology domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3484</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513641.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3484"/>
    <dbReference type="EnsemblBacteria" id="ABB33689">
        <property type="protein sequence ID" value="ABB33689"/>
        <property type="gene ID" value="Gmet_3484"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3484"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0607">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_2_7"/>
    <dbReference type="OMA" id="ACGIPYW"/>
    <dbReference type="OrthoDB" id="1149616at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="SSF52821"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="2">
        <location>
            <begin position="472"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="561" mass="59143" checksum="072C43FC17BEA4E8" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q42</accession>
    <name>RECR_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Recombination protein RecR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">recR</name>
        <name type="ordered locus">Gmet_3420</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RecR family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514227.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Q42"/>
    <dbReference type="SMR" id="Q39Q42"/>
    <dbReference type="STRING" id="269799.Gmet_3420"/>
    <dbReference type="EnsemblBacteria" id="ABB33632">
        <property type="protein sequence ID" value="ABB33632"/>
        <property type="gene ID" value="Gmet_3420"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3420"/>
    <dbReference type="eggNOG" id="COG0353">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060739_1_0_7"/>
    <dbReference type="OMA" id="DVMAIEN"/>
    <dbReference type="OrthoDB" id="1661836at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01025">
        <property type="entry name" value="TOPRIM_recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00017">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000093">
        <property type="entry name" value="DNA_Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023627">
        <property type="entry name" value="Rcmb_RecR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023628">
        <property type="entry name" value="Rcmb_RecR_C4-type_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034137">
        <property type="entry name" value="TOPRIM_RecR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30446">
        <property type="entry name" value="PTHR30446"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02132">
        <property type="entry name" value="RecR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13662">
        <property type="entry name" value="Toprim_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111304">
        <property type="entry name" value="SSF111304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00615">
        <property type="entry name" value="recR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <keyword id="KW-0863">Zinc-finger</keyword>
    <feature type="chain" id="PRO_1000001546" description="Recombination protein RecR">
        <location>
            <begin position="1"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Toprim" evidence="1">
        <location>
            <begin position="79"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="1">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00017"/>
        </source>
    </evidence>
    <sequence length="197" mass="21768" checksum="FD44D37F7FF7DA60" modified="2005-11-22" version="1">MLQSSNSFARLLAELQKLPGVGEKTALRLAFHLLKYPENTAALAESLGEVLSRVKFCSVCFGITEEDPCRLCSSDRDETSLCVVEEPQDLLAVERTRAFRGRYHVLQGALSPLNGVTPDRLRIAELMRRLEEGTVREVVIATNFSVEGETTALYLARQIKPLGIRVTRLAHGIPLGSDLEYVDAATVQRALEGRSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q93</accession>
    <name>Q39Q93_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system protein I</fullName>
            <shortName evidence="4">T2SS minor pseudopilin I</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gspI</name>
        <name evidence="5" type="ordered locus">Gmet_3369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Type II secretion is composed of four main components: the outer membrane complex, the inner membrane complex, the cytoplasmic secretion ATPase and the periplasm-spanning pseudopilus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell inner membrane</location>
            <topology evidence="4">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="4">Cleaved by prepilin peptidase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GSP I family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512595.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3369"/>
    <dbReference type="EnsemblBacteria" id="ABB33581">
        <property type="protein sequence ID" value="ABB33581"/>
        <property type="gene ID" value="Gmet_3369"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3369"/>
    <dbReference type="eggNOG" id="COG2165">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121289_8_0_7"/>
    <dbReference type="OMA" id="NQIRLTV"/>
    <dbReference type="OrthoDB" id="1964705at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010052">
        <property type="entry name" value="T2SS_protein-GspI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38779">
        <property type="entry name" value="PTHR38779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01707">
        <property type="entry name" value="gspI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="123" mass="13851" checksum="015CCB24FE2AAD7B" modified="2005-11-22" version="1">MRRPTLLCGDAGGFTLLEVMVALAIMAGVVFTVIGAVNYHLSIVERDRRETVAVLLARQKLSDLEEEKDIPEKKEGTFAPTRPEYSWEMTATPTEVESLRRMTLVVSWDNKKRSVALVRYLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QE1</accession>
    <name>Q39QE1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Methyl viologen-reducing hydrogenase, large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">mvhL</name>
        <name evidence="4" type="ordered locus">Gmet_3320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512544.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3320"/>
    <dbReference type="DNASU" id="3740713"/>
    <dbReference type="EnsemblBacteria" id="ABB33533">
        <property type="protein sequence ID" value="ABB33533"/>
        <property type="gene ID" value="Gmet_3320"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3320"/>
    <dbReference type="eggNOG" id="COG3259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044556_0_0_7"/>
    <dbReference type="OMA" id="VQNNPAM"/>
    <dbReference type="OrthoDB" id="1967820at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008901">
        <property type="term" value="F:ferredoxin hydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001501">
        <property type="entry name" value="Ni-dep_hyd_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018194">
        <property type="entry name" value="Ni-dep_hyd_lsu_Ni_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00374">
        <property type="entry name" value="NiFeSe_Hases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="SSF56762"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00508">
        <property type="entry name" value="NI_HGENASE_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="473" mass="51459" checksum="B87B34CA9E58F594" modified="2005-11-22" version="1">MNKTITIDPVTRIEGHARVFIDLDDGGALKAAGLVVNELRGFEKILTGMDADRMPLVTARICGVCPTAHHLAATNALDNAAGVEPPTAAKLLRELMYMGHLIHSHCLSLFVLQGPDLVLGLDADPAIRNVVGVVQAVPDIARKALQCRSIGQKINELVGGRGTHPVTSVAGGIAFVLDADRERQLNAWIQEAHGLVLELAPVVKQLLMKMLDANPAMLEQWVIPAWSVGTVKGDGTIALVNGEIRAIDESGARKAQFPTAGYDTHLSEAAVDFSYMKQVSFVEGETRHDYRVGPLARLNISDRYGTPLADREREEFIRTVGRPCHANALQPWARLIELLYCTERAQEIMASPEIHGETRVPVKFSGGRGVGHVEAPRGTLIHDYEIDENGIVRAANLIVATQQNYALINTMIAQAATSHVINRPDDQALLNAVEFGIRCYDPCLSCATHALGAMPLEIVVNRADRPHLIRRNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QM5</accession>
    <name>Q39QM5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Magnesium-dependent deoxyribonuclease, TatD family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3236</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366165.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3236"/>
    <dbReference type="EnsemblBacteria" id="ABB33449">
        <property type="protein sequence ID" value="ABB33449"/>
        <property type="gene ID" value="Gmet_3236"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3236"/>
    <dbReference type="eggNOG" id="COG0084">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031506_4_0_7"/>
    <dbReference type="OMA" id="CHLDAGE"/>
    <dbReference type="OrthoDB" id="915852at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004536">
        <property type="term" value="F:deoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015991">
        <property type="entry name" value="Hydrolase_TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00010">
        <property type="entry name" value="TIGR00010"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01090">
        <property type="entry name" value="TATD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="252" mass="27056" checksum="01A441F36FAAAD8D" modified="2005-11-22" version="1">MLTDTHCHLDDPTLSSRLGEVMAAARQAGVGRIIVPGIAPGGWERIASLAREQEGIFPAFGIYPQTAGQADDGALARLATLSGTAVAVGEIGLDHLLSTVPHETQEAAFRKQLRIAVVAGLPVIIHCRRAFEPLLRILREESVSRVGGVMHAFSGSVEIARECIRLGLFISVAGTVTYRNAVRPVTVAREIPLEHLLIETDAPDMTPEPFRGAPNEPAFLAVTAHRLAELKGVTPEEVARATSENAVRLFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QP2</accession>
    <name>Q39QP2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14 15">UvrABC system protein B</fullName>
            <shortName evidence="14">Protein UvrB</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Excinuclease ABC subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14 19" type="primary">uvrB</name>
        <name evidence="19" type="ordered locus">Gmet_3219</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 14">The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12 14 15">Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="14">The beta-hairpin motif is involved in DNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the UvrB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512658.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3219"/>
    <dbReference type="EnsemblBacteria" id="ABB33432">
        <property type="protein sequence ID" value="ABB33432"/>
        <property type="gene ID" value="Gmet_3219"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3219"/>
    <dbReference type="eggNOG" id="COG0556">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009621_2_1_7"/>
    <dbReference type="OMA" id="EYVDRMV"/>
    <dbReference type="OrthoDB" id="95696at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009380">
        <property type="term" value="C:excinuclease repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009381">
        <property type="term" value="F:excinuclease ABC activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009432">
        <property type="term" value="P:SOS response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00204">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001943">
        <property type="entry name" value="UVR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036876">
        <property type="entry name" value="UVR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004807">
        <property type="entry name" value="UvrB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041471">
        <property type="entry name" value="UvrB_inter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024759">
        <property type="entry name" value="UvrB_YAD/RRR_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24029">
        <property type="entry name" value="PTHR24029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12344">
        <property type="entry name" value="UvrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17757">
        <property type="entry name" value="UvrB_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46600">
        <property type="entry name" value="SSF46600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00631">
        <property type="entry name" value="uvrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50151">
        <property type="entry name" value="UVR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 14 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 14 15" id="KW-0228">DNA excision</keyword>
    <keyword evidence="9 14 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 14 15" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14 15" id="KW-0742">SOS response</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="25"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="430"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="domain" description="UVR" evidence="16">
        <location>
            <begin position="624"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Beta-hairpin" evidence="14">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00026033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABB33432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="665" mass="76254" checksum="DC0A84F023A6DB91" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QR7</accession>
    <name>Q39QR7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ferredoxin, Rieske superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3194</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512632.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3194"/>
    <dbReference type="EnsemblBacteria" id="ABB33407">
        <property type="protein sequence ID" value="ABB33407"/>
        <property type="gene ID" value="Gmet_3194"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3194"/>
    <dbReference type="eggNOG" id="COG2146">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_055690_5_0_7"/>
    <dbReference type="OMA" id="QGGPLCS"/>
    <dbReference type="OrthoDB" id="1681886at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="SSF50022"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="4">
        <location>
            <begin position="2"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="100" mass="10940" checksum="FDA1416588CEB67D" modified="2005-11-22" version="1">MDFAAKVSDVPDWGKKIVTVKGQEILLVKTKGNIYACETECPHQGAPLSGALVKEEGHISCQRHGYRFSLKTGACKEFPEYTLKVYPVEVAGDDVLVGLE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-26" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QR8</accession>
    <name>PURT_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Formate-dependent phosphoribosylglycinamide formyltransferase</fullName>
            <ecNumber evidence="1">6.3.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">5'-phosphoribosylglycinamide transformylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Formate-dependent GAR transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">GAR transformylase 2</fullName>
            <shortName evidence="1">GART 2</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Non-folate glycinamide ribonucleotide transformylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylglycinamide formyltransferase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purT</name>
        <name type="ordered locus">Gmet_3193</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + formate + N(1)-(5-phospho-beta-D-ribosyl)glycinamide = ADP + H(+) + N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + phosphate</text>
            <dbReference type="Rhea" id="RHEA:24829"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.1.21"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:24830"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-ribosyl)glycinamide (formate route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PurK/PurT family.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512631.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QR8"/>
    <dbReference type="SMR" id="Q39QR8"/>
    <dbReference type="STRING" id="269799.Gmet_3193"/>
    <dbReference type="EnsemblBacteria" id="ABB33406">
        <property type="protein sequence ID" value="ABB33406"/>
        <property type="gene ID" value="Gmet_3193"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3193"/>
    <dbReference type="eggNOG" id="COG0027">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011534_1_3_7"/>
    <dbReference type="OMA" id="GMVTMIT"/>
    <dbReference type="OrthoDB" id="1677960at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00127"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043815">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase 2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004644">
        <property type="term" value="F:phosphoribosylglycinamide formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01643">
        <property type="entry name" value="PurT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003135">
        <property type="entry name" value="ATP-grasp_carboxylate-amine"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005862">
        <property type="entry name" value="PurT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02222">
        <property type="entry name" value="ATP-grasp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01142">
        <property type="entry name" value="purT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000319174" description="Formate-dependent phosphoribosylglycinamide formyltransferase">
        <location>
            <begin position="1"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="1">
        <location>
            <begin position="117"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="20"/>
            <end position="21"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="158"/>
            <end position="163"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="193"/>
            <end position="196"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="361"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>N(1)-(5-phospho-beta-D-ribosyl)glycinamide</name>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01643"/>
        </source>
    </evidence>
    <sequence length="392" mass="42283" checksum="202F78BF2881AFB0" modified="2005-11-22" version="1">MIGTPLKKSATRVMLLGSGELGKEVVLEAQRLGVEVIAVDRYADAPAMQVAHRAHVVNMLDRVELGRIVARERPHLIVPEIEAIDTPYLLELEQEGYTVIPTARAANLTMNREGIRRLAAEELGLPTAAYRFAASIESFRAAVKDIGLPCVVKPIMSSSGKGQSVVKSMEEIDGAWTYAMEGGRGASDTVIVEEFIPFDYEITLLTVRHAGGTTFCPPIGHVQIKGDYHESWQPMAMTPAALAESQRQAKAVTDALGGSGIFGVELFIKGDRVWFSEVSPRPHDTGMVTMISQNLSEFELHVRAILGLPVPEVANLAPAASHVVLASEAAEEVTFSGLDAALSVPETKLRLFGKPDTRPGRRMGVALSFGADTDEARNRAEQAAHAVKIVTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QX3</accession>
    <name>Q39QX3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Type IIs restriction endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366150.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3138"/>
    <dbReference type="REBASE" id="11549">
        <property type="entry name" value="GmeIP"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33351">
        <property type="protein sequence ID" value="ABB33351"/>
        <property type="gene ID" value="Gmet_3138"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3138"/>
    <dbReference type="eggNOG" id="COG1578">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_474000_0_0_7"/>
    <dbReference type="OMA" id="YEMEGEP"/>
    <dbReference type="OrthoDB" id="113610at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018573">
        <property type="entry name" value="Restrct_endonuc_II_AlwI"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09491">
        <property type="entry name" value="RE_AlwI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="572" mass="64903" checksum="BF30685ABAEA8189" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QZ5</accession>
    <name>Q39QZ5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 5">Flagellar basal body rod protein FlgB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">flgB</name>
        <name evidence="6" type="ordered locus">Gmet_3115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">The basal body constitutes a major portion of the flagellar organelle and consists of a number of rings mounted on a central rod.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Bacterial flagellum basal body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the flagella basal body rod proteins family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514290.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3115"/>
    <dbReference type="EnsemblBacteria" id="ABB33329">
        <property type="protein sequence ID" value="ABB33329"/>
        <property type="gene ID" value="Gmet_3115"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3115"/>
    <dbReference type="eggNOG" id="COG1815">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125463_3_0_7"/>
    <dbReference type="OMA" id="KSLYEPH"/>
    <dbReference type="OrthoDB" id="1914857at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030694">
        <property type="term" value="C:bacterial-type flagellum basal body, rod"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006300">
        <property type="entry name" value="FlgB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30435:SF12">
        <property type="entry name" value="PTHR30435:SF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002889">
        <property type="entry name" value="Rod_FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01396">
        <property type="entry name" value="FlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0975">Bacterial flagellum</keyword>
    <keyword evidence="6" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="6" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB33329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="140" mass="15359" checksum="2B9FCC6B95DA423F" modified="2005-11-22" version="1">MPIDKIFGTTVDLLAKSIDLRSRSHTMISANLANVETPNYTPTALSFENELKGALKGKKVGTPAITHPKHIPLKGQSNSIQQVQGTVIDTSSLSPGKDYNGVDLETEMSRMAENQIMYNASIQILSKQFNEIKSAIRENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R23</accession>
    <name>Q39R23_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Methyl-accepting chemotaxis sensory transducer, class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">mcp40H-3</name>
        <name evidence="7" type="ordered locus">Gmet_3087</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514541.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3087"/>
    <dbReference type="EnsemblBacteria" id="ABB33301">
        <property type="protein sequence ID" value="ABB33301"/>
        <property type="gene ID" value="Gmet_3087"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3087"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_11_7"/>
    <dbReference type="OMA" id="HQKMQLE"/>
    <dbReference type="OrthoDB" id="633705at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="453"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="6">
        <location>
            <begin position="478"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="5">
        <location>
            <begin position="535"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="80"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="807" mass="86943" checksum="E735DADB067828EA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-07-25" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R35</accession>
    <name>QUEC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">7-cyano-7-deazaguanine synthase</fullName>
            <ecNumber evidence="1">6.3.4.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">7-cyano-7-carbaguanine synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">PreQ(0) synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Queuosine biosynthesis protein QueC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">queC</name>
        <name type="ordered locus">Gmet_3075</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7-carboxy-7-deazaguanine + ATP + NH4(+) = 7-cyano-7-deazaguanine + ADP + H(+) + H2O + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27982"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:45075"/>
            <dbReference type="ChEBI" id="CHEBI:61036"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; 7-cyano-7-deazaguanine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the QueC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.20" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513634.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39R35"/>
    <dbReference type="SMR" id="Q39R35"/>
    <dbReference type="STRING" id="269799.Gmet_3075"/>
    <dbReference type="EnsemblBacteria" id="ABB33289">
        <property type="protein sequence ID" value="ABB33289"/>
        <property type="gene ID" value="Gmet_3075"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3075"/>
    <dbReference type="eggNOG" id="COG0603">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_081854_1_1_7"/>
    <dbReference type="OMA" id="CESCMRR"/>
    <dbReference type="OrthoDB" id="1681374at2"/>
    <dbReference type="UniPathway" id="UPA00391"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016879">
        <property type="term" value="F:ligase activity, forming carbon-nitrogen bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008616">
        <property type="term" value="P:queuosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01995">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01633">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018317">
        <property type="entry name" value="QueC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42914">
        <property type="entry name" value="PTHR42914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06508">
        <property type="entry name" value="QueC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006293">
        <property type="entry name" value="ExsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00364">
        <property type="entry name" value="TIGR00364"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0671">Queuosine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000246845" description="7-cyano-7-deazaguanine synthase">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01633"/>
        </source>
    </evidence>
    <sequence length="237" mass="25616" checksum="4E6EB43F3DAA4309" modified="2005-11-22" version="1">MHKKAVVLYSGGLDSTTCLAIARAEGYEPYAMSFSYGQRHSVELEQAKRNARPMGAVDHLVVEFDYRQVGGSALTSDIAVPKEGVGSDIPVTYVPARNTVFLSFALGWAEVLGAFDIFIGVNALDYSGYPDCRPEYIAAFEAMANLATKAGVEGKGRFRIHTPLIHLTKAEIIRKGLSLGVDYGRTHSCYDPTPEGLACGLCDSCRLRLKGFAEAGVADPVAYATIKNPEVRSQESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R55</accession>
    <name>Q39R55_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3054</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513614.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3054"/>
    <dbReference type="EnsemblBacteria" id="ABB33269">
        <property type="protein sequence ID" value="ABB33269"/>
        <property type="gene ID" value="Gmet_3054"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3054"/>
    <dbReference type="HOGENOM" id="CLU_1793723_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="144" mass="16157" checksum="1F21291B54EC9779" modified="2005-11-22" version="1">MSTEERDGGLSQRGSNKRLLLLATILVPLLTITFGMRSKAAKLPSPEIRLSDTTPRGQEVSSEQRQRFRLNFQEKFSKKFQGSKVDLEGDGGKTFCIEWPGVDRSFAATITETGEIIKDLRDMGFTHLIISDGHKSNWNVDLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RC4</accession>
    <name>Q39RC4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2985"/>
    <dbReference type="EnsemblBacteria" id="ABB33200">
        <property type="protein sequence ID" value="ABB33200"/>
        <property type="gene ID" value="Gmet_2985"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2985"/>
    <dbReference type="eggNOG" id="ENOG502ZRAW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2990247_0_0_7"/>
    <dbReference type="OMA" id="QQMEINL"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="57" mass="6621" checksum="86727978F338A74C" modified="2005-11-22" version="1">MMEKENETIEKLAEDAEINLSTDYDKRDLKERRGVQKGNLYDGSKKLKHSVPKGKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RJ3</accession>
    <name>Q39RJ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512849.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2913"/>
    <dbReference type="EnsemblBacteria" id="ABB33131">
        <property type="protein sequence ID" value="ABB33131"/>
        <property type="gene ID" value="Gmet_2913"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2913"/>
    <dbReference type="HOGENOM" id="CLU_189842_1_1_7"/>
    <dbReference type="OrthoDB" id="4960at213422"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223453" evidence="2">
        <location>
            <begin position="24"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="77" mass="8205" checksum="4EF91083277B62C9" modified="2005-11-22" version="1">MKSSAPIINALVLLFGSVSSVFAASGAREDNSGIFVWIFLGFCALIVVLQLVPAVLMMLGMAKGLKKELPQEQKATH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RR9</accession>
    <name>Q39RR9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylate kinase-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513966.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2837"/>
    <dbReference type="EnsemblBacteria" id="ABB33055">
        <property type="protein sequence ID" value="ABB33055"/>
        <property type="gene ID" value="Gmet_2837"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2837"/>
    <dbReference type="eggNOG" id="COG1102">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065155_2_1_7"/>
    <dbReference type="OMA" id="RWKSDKD"/>
    <dbReference type="OrthoDB" id="1962890at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="236" mass="27365" checksum="2C4150D281A6ECCC" modified="2005-11-22" version="1">MPEKLLVPSIEQRLAAMVEVSRRMRGKTEAEKRMGRKPTITISREFGCEGYPVAEQLRELLEHSTREPWVVMDKALLEEAAKHHDISETVLQSLGQRPRFLDDMISTLMPRWKTERDHYKLLCDQIVSLAEVGNVIIIGRGSSIITQQMNNCLHFRIYASHHFKVRSIARRAKISIQDAELLVEKMQKERVKFIRSFLDRDIADLNLYHMAFNNDKNSEAQIARAIFDYLCQKIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RS4</accession>
    <name>Q39RS4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0751 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513971.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2832"/>
    <dbReference type="EnsemblBacteria" id="ABB33050">
        <property type="protein sequence ID" value="ABB33050"/>
        <property type="gene ID" value="Gmet_2832"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2832"/>
    <dbReference type="eggNOG" id="ENOG5033090">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_157120_1_0_7"/>
    <dbReference type="OMA" id="TVSHKMV"/>
    <dbReference type="OrthoDB" id="1959295at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016772">
        <property type="entry name" value="UCP020408"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10087">
        <property type="entry name" value="DUF2325"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="100" mass="11116" checksum="6EC47BCF856ECA92" modified="2005-11-22" version="1">MCIAVIGGMDRLERHYRQEAARTGFELRVFSQSENNIATKLKRFDALVIFTNKVSHRVRNEAMSAAKLNGIPVFQYHSCGVCTLRDCLNCLVLPAGGGTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RW3</accession>
    <name>Q39RW3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511670.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2793"/>
    <dbReference type="EnsemblBacteria" id="ABB33011">
        <property type="protein sequence ID" value="ABB33011"/>
        <property type="gene ID" value="Gmet_2793"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2793"/>
    <dbReference type="eggNOG" id="COG2242">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037315_0_0_7"/>
    <dbReference type="OMA" id="IPRIFNI"/>
    <dbReference type="OrthoDB" id="1687413at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017031">
        <property type="entry name" value="Pre_MeTrfase_YjhP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF034653">
        <property type="entry name" value="Mtase_yjhp_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltranfer_dom" evidence="1">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="248" mass="27270" checksum="24ECAF4E888FF411" modified="2005-11-22" version="1">MDIPRIFNITESAHRIHNPFTPEKFATLGAALRLETGAHLLDLGSGSGEMLCTWARDHGVIGTGIDMSRLFTEQAKLRAVELGVADQVKFIHGDAVGYVSDEKVGVAACVGATWIGGGVAGTIELLARSLRTGGIILIGEPYWRQLPPTEDVAKGCLANSISDFLMLPELIASFGHLGYDVVEMVLADQDGWDRYEAAKWLTMRRWLEANPDDELAKEVRAQLTSEPERYTAYTREYLGWGVFALMSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S21</accession>
    <name>Q39S21_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ligand-gated TonB-dependent outer membrane channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366092.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2735"/>
    <dbReference type="EnsemblBacteria" id="ABB32953">
        <property type="protein sequence ID" value="ABB32953"/>
        <property type="gene ID" value="Gmet_2735"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2735"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_18_5_7"/>
    <dbReference type="OMA" id="FRNDTWD"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="81"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="295"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="650" mass="71808" checksum="44731884256C3E06" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S23</accession>
    <name>Q39S23_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BioD and DRTGG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32951.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366091.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2733"/>
    <dbReference type="EnsemblBacteria" id="ABB32951">
        <property type="protein sequence ID" value="ABB32951"/>
        <property type="gene ID" value="Gmet_2733"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2733"/>
    <dbReference type="eggNOG" id="COG0857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040984_1_0_7"/>
    <dbReference type="OMA" id="VDCNNAR"/>
    <dbReference type="OrthoDB" id="687829at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32951.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="364" mass="39707" checksum="8803C08C0B0497BF" modified="2012-10-31" version="2">MCKKVFIAATGMNSGKTTISVSLMHLARKKYGRVGFIKAIGPKCQLFNDITVDMDAALMARIFGLEGDINHMSPVVLERGSTKRFIDGEIPTLWPAERITEAVRELERKNDYLIIEGSGHGGVGSVIGMNNAKVAKLVDAPAIMVSGGGIGNVIDSVQLNLPLYRMEGADLRMLLVNKLIPEKRETSLSYLQRAFTPHGINVVGAFDWSPILANPTLNNIARLLAHPLRGDQSQGTRIIHHIQLGAASSQKVIDGLAESTMLLVTSSRDELLVTLSSLYNIPAYREKIAGLVVPGHAPVSAITQKILDDSSIPYIRIHETTADIFSAMKYHVSKISAEDAEKIDLVKAQAEKVLDFDELDRMLS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S28</accession>
    <name>DNLJ_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA ligase</fullName>
            <ecNumber evidence="1">6.5.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Polydeoxyribonucleotide synthase [NAD(+)]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ligA</name>
        <name type="ordered locus">Gmet_2728</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>NAD(+) + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + beta-nicotinamide D-nucleotide.</text>
            <dbReference type="EC" id="6.5.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD-dependent DNA ligase family. LigA subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511732.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39S28"/>
    <dbReference type="SMR" id="Q39S28"/>
    <dbReference type="STRING" id="269799.Gmet_2728"/>
    <dbReference type="EnsemblBacteria" id="ABB32946">
        <property type="protein sequence ID" value="ABB32946"/>
        <property type="gene ID" value="Gmet_2728"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2728"/>
    <dbReference type="eggNOG" id="COG0272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007764_2_1_7"/>
    <dbReference type="OMA" id="HDVEHEI"/>
    <dbReference type="OrthoDB" id="241401at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003911">
        <property type="term" value="F:DNA ligase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00114">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01588">
        <property type="entry name" value="DNA_ligase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041663">
        <property type="entry name" value="DisA/LigA_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018239">
        <property type="entry name" value="DNA_ligase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033136">
        <property type="entry name" value="DNA_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001679">
        <property type="entry name" value="DNAligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013839">
        <property type="entry name" value="DNAligase_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013840">
        <property type="entry name" value="DNAligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003583">
        <property type="entry name" value="Hlx-hairpin-Hlx_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004150">
        <property type="entry name" value="NAD_DNA_ligase_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004149">
        <property type="entry name" value="Znf_DNAligase_C4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01653">
        <property type="entry name" value="DNA_ligase_aden"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03120">
        <property type="entry name" value="DNA_ligase_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03119">
        <property type="entry name" value="DNA_ligase_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12826">
        <property type="entry name" value="HHH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001604">
        <property type="entry name" value="LigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00278">
        <property type="entry name" value="HhH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00532">
        <property type="entry name" value="LIGANc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="SSF47781"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="SSF52113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00575">
        <property type="entry name" value="dnlj"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01055">
        <property type="entry name" value="DNA_LIGASE_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01056">
        <property type="entry name" value="DNA_LIGASE_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0464">Manganese</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000313249" description="DNA ligase">
        <location>
            <begin position="1"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="591"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="active site" description="N6-AMP-lysine intermediate" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="34"/>
            <end position="38"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="83"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="434"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01588"/>
        </source>
    </evidence>
    <sequence length="671" mass="74225" checksum="B68E504C941EF1DA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S66</accession>
    <name>Q39S66_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Prolidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511771.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2690"/>
    <dbReference type="EnsemblBacteria" id="ABB32908">
        <property type="protein sequence ID" value="ABB32908"/>
        <property type="gene ID" value="Gmet_2690"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2690"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_10_0_7"/>
    <dbReference type="OMA" id="RMRAFNG"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="2">
        <location>
            <begin position="12"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="1">
        <location>
            <begin position="146"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="397" mass="44294" checksum="FAA5815F7EAB44E5" modified="2005-11-22" version="1">MRLTPRDELEYRIKKLQAYMAEAGLDAVIVVQNADLFYFTGTIQNGALYVPVAGDPIYMVRKEVSRARMESGLKEIVPFASMREIPEILTKYGYATPIRIGMEFDVVPVNFFARYRAVFPAGDFVDASTLIRRVRMIKSKYEIHLLQDAANQVDKVYRRAREVVREGMTDLELAAELEFAARKEAHQGYVRMRGFNAELFFAQVFSGTDTAVPAYMDTPLGGLGLNPSFGQGAGLKRIERGEPIIVDFAGCVDGYLVDQTRVIALGALSDRMKKAYDDMLRVQERMTEVAVPGTPWSHVYDVCVALAAELGYADNFMGAKGARVSFIGHGIGIEVDEYPFIAKGFTDMVLEPGMVFAFEPKVIFPGEGAIGIENTFYISHYEGLKQLTFSDQELLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SE8</accession>
    <name>Q39SE8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">UDP-3-O-acyl-N-acetylglucosamine deacetylase</fullName>
            <shortName evidence="12">UDP-3-O-acyl-GlcNAc deacetylase</shortName>
            <ecNumber evidence="4 12">3.5.1.108</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">lpxC</name>
        <name evidence="13" type="ordered locus">Gmet_2607</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 12">Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>a UDP-3-O-[(3R)-3-hydroxyacyl]-N-acetyl-alpha-D-glucosamine + H2O = a UDP-3-O-[(3R)-3-hydroxyacyl]-alpha-D-glucosamine + acetate</text>
            <dbReference type="Rhea" id="RHEA:67816"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:137740"/>
            <dbReference type="ChEBI" id="CHEBI:173225"/>
            <dbReference type="EC" id="3.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 2/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the LpxC family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.108" evidence="4 12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511854.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2607"/>
    <dbReference type="EnsemblBacteria" id="ABB32826">
        <property type="protein sequence ID" value="ABB32826"/>
        <property type="gene ID" value="Gmet_2607"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2607"/>
    <dbReference type="eggNOG" id="COG0774">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046528_1_0_7"/>
    <dbReference type="OMA" id="LPRREFG"/>
    <dbReference type="OrthoDB" id="428602at2"/>
    <dbReference type="UniPathway" id="UPA00359">
        <property type="reaction ID" value="UER00478"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008759">
        <property type="term" value="F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103117">
        <property type="term" value="F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009245">
        <property type="term" value="P:lipid A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1700.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00388">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004463">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011334">
        <property type="entry name" value="UDP-acyl_GlcNac_deAcase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015870">
        <property type="entry name" value="UDP-acyl_N-AcGlcN_deAcase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33694">
        <property type="entry name" value="PTHR33694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03331">
        <property type="entry name" value="LpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00325">
        <property type="entry name" value="lpxC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0441">Lipid A biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="275" mass="30912" checksum="85C82D7314C3E7B8" modified="2005-11-22" version="1">MIKRQTTINRIFKLSGIGLHTGRTVTLEFLPRREFGIAFVFGGSLIPARYDMVADTRLSTQIAAEGASVATIEHLMAAFYYSGITNCLVYIDGPEVPIMDGSAWEFYHEMWRAGVYEFPEAGVYLKVLRPVEATLKDAWVRVKPLNTLDITMTIEFRPPVGKQRKRVMDVENAVSIINSRTFVLHEEIEAIRKAGLAKGGSLDNAVVIGGESIVNPHGLRYKQELVNHKILDLIGDLYTCGYRMLGKVEAHKTGHHLNNLLLREIFSDPENYAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SF5</accession>
    <name>Q39SF5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ech-hydrogenase-related complex, NuoH-like integral membrane subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ehrB-1</name>
        <name evidence="6" type="ordered locus">Gmet_2600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511861.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2600"/>
    <dbReference type="EnsemblBacteria" id="ABB32819">
        <property type="protein sequence ID" value="ABB32819"/>
        <property type="gene ID" value="Gmet_2600"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2600"/>
    <dbReference type="eggNOG" id="COG0650">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015134_2_0_7"/>
    <dbReference type="OMA" id="MRIFRVP"/>
    <dbReference type="OrthoDB" id="1559067at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001694">
        <property type="entry name" value="NADH_UbQ_OxRdtase_su1/FPO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00146">
        <property type="entry name" value="NADHdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="302" mass="32264" checksum="0CFC8010A6C6AEDA" modified="2005-11-22" version="1">MTDIIIHCAVALLLPPLLLGVIGKTKAAFAGRVGAPYLQPYFDLIKLFRKGSVFSETTTWVFRAGPLITLSAALIAVLLIPLGRHVAPLSFSGDLILFAYLFGLSRFFTTIAALDTGSSFEGMGAAREVTFSCLAEPTLFFSLLTLARISKSLSLSTILTHPTPAIWLAAGASMLLLVGALFITLLAENSRIPFDDPNTHLELTMIHEVMVLDHSGPAFGIILYGAALKLFILGAVFVNIAFPVATGNALLDWGIFIVAMLVLAVAIGVVESVMARLRLVRVPQLLVGATILSAFAMLLVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SK9</accession>
    <name>Q39SK9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribonuclease E</fullName>
            <shortName evidence="5">RNase E</shortName>
            <ecNumber evidence="5">3.1.26.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rne</name>
        <name evidence="8" type="ordered locus">Gmet_2546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Endonucleolytic cleavage of single-stranded RNA in A- and U-rich regions.</text>
            <dbReference type="EC" id="3.1.26.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="5">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 2 Zn(2+) ions per homotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer formed by a dimer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RNase E/G family. RNase E subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.12" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513488.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2546"/>
    <dbReference type="EnsemblBacteria" id="ABB32765">
        <property type="protein sequence ID" value="ABB32765"/>
        <property type="gene ID" value="Gmet_2546"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2546"/>
    <dbReference type="eggNOG" id="COG1530">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003468_5_2_7"/>
    <dbReference type="OMA" id="TGEVHAQ"/>
    <dbReference type="OrthoDB" id="1209444at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008995">
        <property type="term" value="F:ribonuclease E activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00970">
        <property type="entry name" value="RNase_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019307">
        <property type="entry name" value="RNA-bd_AU-1/RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028878">
        <property type="entry name" value="RNase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004659">
        <property type="entry name" value="RNase_E/G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30001">
        <property type="entry name" value="PTHR30001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10150">
        <property type="entry name" value="RNase_E_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00757">
        <property type="entry name" value="RNaseEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="40"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Required for zinc-mediated homotetramerization and catalytic activity" evidence="5">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="495"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="495"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="566"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="690"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="806" mass="89522" checksum="6DC6BE88455197E7" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SN2</accession>
    <name>EFG2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor G 2</fullName>
            <shortName evidence="1">EF-G 2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fusA2</name>
        <name type="ordered locus">Gmet_2521</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514530.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SN2"/>
    <dbReference type="SMR" id="Q39SN2"/>
    <dbReference type="STRING" id="269799.Gmet_2521"/>
    <dbReference type="EnsemblBacteria" id="ABB32742">
        <property type="protein sequence ID" value="ABB32742"/>
        <property type="gene ID" value="Gmet_2521"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2521"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_7"/>
    <dbReference type="OMA" id="HKRGEVH"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000263455" description="Elongation factor G 2">
        <location>
            <begin position="1"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="7"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="16"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="80"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="134"/>
            <end position="137"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <sequence length="688" mass="74960" checksum="9D0A927AE6513814" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SR0</accession>
    <name>Q39SR0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mrr_cat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366063.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2490"/>
    <dbReference type="EnsemblBacteria" id="ABB32714">
        <property type="protein sequence ID" value="ABB32714"/>
        <property type="gene ID" value="Gmet_2490"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2490"/>
    <dbReference type="eggNOG" id="ENOG5032RV5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1014249_0_0_7"/>
    <dbReference type="OrthoDB" id="783096at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009307">
        <property type="term" value="P:DNA restriction-modification system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007560">
        <property type="entry name" value="Restrct_endonuc_IV_Mrr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04471">
        <property type="entry name" value="Mrr_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mrr_cat" evidence="1">
        <location>
            <begin position="14"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="265" mass="29821" checksum="A6AC32518A30C09E" modified="2005-11-22" version="1">MTKESEGYERLVKDVHDALLKNDGVENITVLQNVKLRGKSGASHQIDVYWEFRLAGVTYKTCIECKQFKESVKKSHVAAFASILEDIGNATGIFATTEGFQNGAKLLAKEKGIRLILVNYILKTIHLTGHFKIPQISVTNLTFDTDHAKQLLRERGLQVYSLQTHDISGRELIFDSQGTPKCKFRDLFTLLPTGSSQEIEPEDAYFPTEIGNLKIKSAEYTVAVHEHQTEDIITVDDVARAIMEDVFENNSLYLREDGSIEAVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="123" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SW5</accession>
    <name>Q39SW5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Potassium-transporting ATPase ATP-binding subunit</fullName>
            <ecNumber evidence="12">7.2.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP phosphohydrolase [potassium-transporting] B chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-binding and translocating subunit B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Potassium-translocating ATPase B chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12 13" type="primary">kdpB</name>
        <name evidence="13" type="ordered locus">Gmet_2434</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O + K(+)(out) = ADP + H(+) + K(+)(in) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">The system is composed of three essential subunits: KdpA, KdpB and KdpC.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cell inner membrane</location>
            <topology evidence="12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.6" evidence="12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512466.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2434"/>
    <dbReference type="EnsemblBacteria" id="ABB32659">
        <property type="protein sequence ID" value="ABB32659"/>
        <property type="gene ID" value="Gmet_2434"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2434"/>
    <dbReference type="eggNOG" id="COG2216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025728_2_0_7"/>
    <dbReference type="OMA" id="ILWLWFT"/>
    <dbReference type="OrthoDB" id="237367at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008556">
        <property type="term" value="F:P-type potassium transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02078">
        <property type="entry name" value="P-type_ATPase_K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00285">
        <property type="entry name" value="KdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006391">
        <property type="entry name" value="P-type_ATPase_bsu_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43743">
        <property type="entry name" value="PTHR43743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="SSF81653"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="SSF81660"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="SSF81665"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01497">
        <property type="entry name" value="kdpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 12" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="593"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="623"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="658"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="385"/>
            <end position="392"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="527"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="531"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="689" mass="72914" checksum="BACA5AF05236BFC9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T88</accession>
    <name>Q39T88_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cheA40H</name>
        <name evidence="7" type="ordered locus">Gmet_2311</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513309.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2311"/>
    <dbReference type="EnsemblBacteria" id="ABB32536">
        <property type="protein sequence ID" value="ABB32536"/>
        <property type="gene ID" value="Gmet_2311"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2311"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_6_7"/>
    <dbReference type="OMA" id="HILPVIW"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="6">
        <location>
            <begin position="4"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="319"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="5">
        <location>
            <begin position="553"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="690" mass="74037" checksum="FB33FC01A38D9E4D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TB2</accession>
    <name>Q39TB2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sensor histidine kinase, nonconserved putative heme-binding site</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514511.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2287"/>
    <dbReference type="EnsemblBacteria" id="ABB32512">
        <property type="protein sequence ID" value="ABB32512"/>
        <property type="gene ID" value="Gmet_2287"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2287"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049578_0_0_7"/>
    <dbReference type="OMA" id="ERVFFHD"/>
    <dbReference type="OrthoDB" id="1326167at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="1">
        <location>
            <begin position="174"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="387" mass="42398" checksum="0DCF0E2D8583FBED" modified="2005-11-22" version="1">MTKAAPKDIAATFFAAAERASRTEVEEVRKQVLLDTTLTSLIDAIPDYALVLNQERQVVAANRHLLDAFGLGIASIIGKRPGETFGCIFSSEGPAGCGTGNHCSVCGAVMSILESQETLIQNCHECHISLNRNDITSMDLEVCSTPATVNGIPVTVCVMRDISDQKRRSVLERVFFHDVINTVGGIHGIAAMLMEHPDLPPEKELEYKEWMVLLSNRLIDEINHQRKLLDAERGEFRPDLGMVRVPDLVREVHALYVTHDIAAGRHLVMGEIADCSIESDGQILHRILGNLVKNALEATPQEGTVTLSCSEDAERVTFAVTNPGVMPAEVQLQIFQRSFSTKAGSGRGIGTYSVKLFGERYLKGKVAFTSREPEGTSFTLSVPKHFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TM4</accession>
    <name>Q39TM4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase, Cap1E-like family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365929.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2171"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32400">
        <property type="protein sequence ID" value="ABB32400"/>
        <property type="gene ID" value="Gmet_2171"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2171"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_8_1_7"/>
    <dbReference type="OMA" id="SYYREGI"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13477">
        <property type="entry name" value="Glyco_trans_4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="2"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="207"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="390" mass="43188" checksum="17C205F343AB4EC1" modified="2005-11-22" version="1">MKVLMICNTDGALYVFRKPIINRLVACGHEVDSISAASRYFEPLNALGVHPLQLDFARHSVSPLSNVRLFRALYAMVRRLKPDVVHNFTHKPAILGSIAARLAGVKGIFITITGLGSLFVHDDPKTRLMRYLLLAQYKFALGFVDTVFFQNPDDMEYFVSKKLVGAGKAVLTYGSGLDLDEYRLPSTEEIARARAMLGAELGVDLRGRKVALFPARGVPEKGFFEFYRAAKTINALEPDAYAFLHLGLVDADAARRISKEGMEQYAADCGVKYLGFKDNIKDYMIASDIVVLPSSYREGTPRSLIEALALGKAIVTTDMPGCRETVIDGWNGYLCRKGDEQSLVAKLLAVDGEMLTAARSRSRRYCETKYDAAWLADLTLGRYQGSLNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TN1</accession>
    <name>Q39TN1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2164</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 4 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the FKBP-type PPIase family.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514751.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2164"/>
    <dbReference type="EnsemblBacteria" id="ABB32393">
        <property type="protein sequence ID" value="ABB32393"/>
        <property type="gene ID" value="Gmet_2164"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2164"/>
    <dbReference type="eggNOG" id="COG0545">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013615_0_1_7"/>
    <dbReference type="OMA" id="RHAKMAK"/>
    <dbReference type="OrthoDB" id="1861282at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000774">
        <property type="entry name" value="PPIase_FKBP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036944">
        <property type="entry name" value="PPIase_FKBP_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01346">
        <property type="entry name" value="FKBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="175"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="261" mass="28432" checksum="524C084550ADC4DE" modified="2005-11-22" version="1">MSRFSHLKWGDYSLKSPESVPAFPCLRGNSRGRRCIPIGIWGLILLFCAVSAALGQEIKGENAKLNYSVGYQVGSDFKAHGVELDPDALMQGVQDAVKQKEPSVSKEEMNKSLTGLKRKIDAAGQTSARQKTAEYRRASEAFLKENAQKEGVKILPSGVQYRVISEGSGKMPTLKDEVKVHYRISRIDGKELGNTYDAGIPRTVSVAKAMPALQEVLPLMAEGSKWQVVIPTGTASGNKEPLDDQGVLIYDLELVSVIPAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TQ2</accession>
    <name>Q39TQ2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Benzoate--coenzyme A ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bamY</name>
        <name evidence="3" type="ordered locus">Gmet_2143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513062.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2143"/>
    <dbReference type="EnsemblBacteria" id="ABB32372">
        <property type="protein sequence ID" value="ABB32372"/>
        <property type="gene ID" value="Gmet_2143"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2143"/>
    <dbReference type="eggNOG" id="COG0365">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_10_7"/>
    <dbReference type="OMA" id="AMMYWAN"/>
    <dbReference type="OrthoDB" id="326708at2"/>
    <dbReference type="BRENDA" id="6.2.1.25">
        <property type="organism ID" value="2414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011957">
        <property type="entry name" value="Benz_CoA_lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02262">
        <property type="entry name" value="benz_CoA_lig"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="24"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="426"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="523" mass="58543" checksum="CB2B061467B72DC4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TT5</accession>
    <name>Q39TT5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0261 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513094.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2110"/>
    <dbReference type="EnsemblBacteria" id="ABB32339">
        <property type="protein sequence ID" value="ABB32339"/>
        <property type="gene ID" value="Gmet_2110"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2110"/>
    <dbReference type="eggNOG" id="COG5441">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_036813_1_0_7"/>
    <dbReference type="OMA" id="SDISMMY"/>
    <dbReference type="OrthoDB" id="824620at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd15488">
        <property type="entry name" value="Tm-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008322">
        <property type="entry name" value="UPF0261"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044122">
        <property type="entry name" value="UPF0261_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06792">
        <property type="entry name" value="UPF0261"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033271">
        <property type="entry name" value="UCP033271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0261" evidence="1">
        <location>
            <begin position="11"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="455" mass="49133" checksum="E0DBED7425C1EB7D" modified="2005-11-22" version="1">MLTRTDGKGSKVLLIAAMDTKGTEARYIESWLAKAGFTTLIMDMGIRGKRPGPVAVTRDEVLRAAGKTWDDIQNVTSEGDAVDIMISGGVKCALALYKADLIQGVISLGGTMGTTLGTGVMRAFPIGFPKVMISTIAAKDTEAFIGNMDIFMLNSVSDLAGLNRITRKVLRNGALAIAGLVREREFHDEFSRPLAVLTTLGTTEATAARMRIHFEAWGYESVTFHTTGTGGQAMERMVNFEPVSAVVDLSLHELIDHHFGGAFDPGPERGRAALQKGIPTVIVPGNIDFLVTGPMAQAQIYFPGRRGHKHNANITCVRTSLEEIQRIAEIMAGYCNESTGPVAVLVPMKGFSCLDHEDGPQPDPEGPRVFAETFARALTRTIHFETVPLHINDEAFSEVIVGALQKIGGLRKIEADRLPSRQPATWSPYSSVHTLDRFSGNQHTTTETTGDALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TV1</accession>
    <name>Q39TV1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Molybdopterin sulfurtransferase MOSC domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">mosC-2</name>
        <name evidence="2" type="ordered locus">Gmet_2094</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513110.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2094"/>
    <dbReference type="EnsemblBacteria" id="ABB32323">
        <property type="protein sequence ID" value="ABB32323"/>
        <property type="gene ID" value="Gmet_2094"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2094"/>
    <dbReference type="eggNOG" id="COG2258">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_122785_1_0_7"/>
    <dbReference type="OMA" id="RHAGKDP"/>
    <dbReference type="OrthoDB" id="1877633at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="152" mass="16376" checksum="2592F7FE63413FAF" modified="2005-11-22" version="1">MGKVMAVCLSKNKGERKTPVDSVRLVPNHGIDGDAHAGDWHRQVSLLAQESIEKMQRMGLSVQAGDFAENITTVGIDLPGLPIGTRLNVGETTLEVTQIGKECHTRCAIYYQAGDCVMPKEGIFARVVRGGGIRPGDAIEVVKPVNNPRLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TX5</accession>
    <name>Q39TX5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Electron transfer flavoprotein-associated cytochrome b and CCG domain pair iron-sulfur cluster-binding oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514033.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2070"/>
    <dbReference type="EnsemblBacteria" id="ABB32299">
        <property type="protein sequence ID" value="ABB32299"/>
        <property type="gene ID" value="Gmet_2070"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2070"/>
    <dbReference type="eggNOG" id="COG0247">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2181">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005304_1_0_7"/>
    <dbReference type="OMA" id="WNIGHGA"/>
    <dbReference type="OrthoDB" id="1951488at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004017">
        <property type="entry name" value="Cys_rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036197">
        <property type="entry name" value="NarG-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02754">
        <property type="entry name" value="CCG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13237">
        <property type="entry name" value="Fer4_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103501">
        <property type="entry name" value="SSF103501"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="5">
        <location>
            <begin position="336"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="663" mass="73183" checksum="882DDB900B5E6132" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TX6</accession>
    <name>Q39TX6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Succinate--CoA ligase [ADP-forming] subunit beta</fullName>
            <ecNumber evidence="6">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Succinyl-CoA synthetase subunit beta</fullName>
            <shortName evidence="6">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">sucC</name>
        <name evidence="9" type="synonym">sucC-2</name>
        <name evidence="9" type="ordered locus">Gmet_2069</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + CoA + succinate = ADP + phosphate + succinyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514034.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2069"/>
    <dbReference type="EnsemblBacteria" id="ABB32298">
        <property type="protein sequence ID" value="ABB32298"/>
        <property type="gene ID" value="Gmet_2069"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2069"/>
    <dbReference type="eggNOG" id="COG0045">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037430_0_2_7"/>
    <dbReference type="OMA" id="REMYFSI"/>
    <dbReference type="OrthoDB" id="316012at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="CoA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_synthase_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="PTHR11815"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="SSF52210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="9"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding; shared with subunit alpha" evidence="6">
        <location>
            <begin position="321"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="53"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="387" mass="41439" checksum="5A03DDA27CDFD62A" modified="2005-11-22" version="1">MNIHEYQAKAILRRFGVPVPDGHVCYNGASAREWAKRLGDGPWVVKAQIHAGGRGKGGGVKLARTSQEVQLIARNMLGMTLRTHQTGPDGKLVTRVLVENGCNIDRELYISLLVDRSTSKVTVMASTEGGMDIEEVAATTPEKIFKEAIDPLVGLSPFQCRNLAFSLGLTGKLLPKAQKLLENLYATFIACDCSLLEINPLVVTKEGDLLALDAKFGFDDNAIFRHLQISDMRDYDEEDPNEVEASQHDLSYVSLNGNIGCLVNGAGLAMATMDIIKFSGGEPANFLDVGGGATIERVTEAFKIILSDKNVKGIFVNIFGGIMKCDVIATGVIEAARQVSLQVPLVVRLEGTNVALGKQLLSESGLNIVAADGMADGAQKIVQAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TY6</accession>
    <name>Q39TY6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2059</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514044.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2059"/>
    <dbReference type="EnsemblBacteria" id="ABB32288">
        <property type="protein sequence ID" value="ABB32288"/>
        <property type="gene ID" value="Gmet_2059"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2059"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_3_7"/>
    <dbReference type="OMA" id="VGTLGKQ"/>
    <dbReference type="OrthoDB" id="1601931at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011284">
        <property type="entry name" value="3oxo_ACP_reduc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01830">
        <property type="entry name" value="3oxo_ACP_reduc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 3" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="155"/>
            <end position="159"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR611284-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="247" mass="26326" checksum="4DF6E44EC974093C" modified="2005-11-22" version="1">MDLKGKNAIVTGASLGIGSAIALDLAKSGANVAINYRKHSEEANAICAEIQKMGQKAIAVQADVASFKDAQAMVDKVAAEFGSVDILVNNAGVNRDAVIWKMTEEQWDECLAINLKGYFNYCRAVAPLMKEQGSGKIVNVTSINGMRGKFGQTNYSAAKAGIIGLTKALARELAKSNVNCNAIAPGLIETEMMAALPEDVKQKSLADIVLGRMGKPEEVAWLVTFLCSEKSRHITGECIKVDGGQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TZ7</accession>
    <name>Q39TZ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514056.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2048"/>
    <dbReference type="EnsemblBacteria" id="ABB32277">
        <property type="protein sequence ID" value="ABB32277"/>
        <property type="gene ID" value="Gmet_2048"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2048"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073018_0_0_7"/>
    <dbReference type="OMA" id="RICHNAI"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029467">
        <property type="entry name" value="Cyt_c7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026352">
        <property type="entry name" value="Nanowire_3heme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039118">
        <property type="entry name" value="QrcA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39425">
        <property type="entry name" value="PTHR39425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14522">
        <property type="entry name" value="Cytochrome_C7"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04257">
        <property type="entry name" value="nanowire_3heme"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223121" evidence="1">
        <location>
            <begin position="23"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="38"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="120"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="200"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome_C7" evidence="2">
        <location>
            <begin position="279"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="340" mass="37128" checksum="9E5872E7BF6336F6" modified="2005-11-22" version="1">MNLRSISIACMLFLACILPATAKETKEITFKLRNAEPVVFSHDYHLAKYNNNCRICHNTLFNLKNRKRYTMLEMEKGKSCGACHTGIKAFSVADDAECVRCHKGKPRPVVFKMKGATDAVFKHELHVPKLGGKCRTCHSNKNIVGARKVTMAQMEKGKSCGACHDSKKAFTVSGNCGKCHQGMAPPKTVAFKIKGVADAAFSHDFHLGMYKCADCHTKLFAYRAGAKHNTMADMEKGKSCGACHNGKDAFASTGDCGKCHPGLKPAKLTWKTSLGEAFFDHGFHLGMFKCADCHTKIFKYKKGASSATMAQMEAGASCGTCHNGKDAFSVKDDCVKCHNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U57</accession>
    <name>Q39U57_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nicotinate-nucleotide diphosphorylase (carboxylating)</fullName>
            <ecNumber evidence="4">2.4.2.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Quinolinate phosphoribosyltransferase [decarboxylating]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">nadC</name>
        <name evidence="13" type="ordered locus">Gmet_1988</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the catabolism of quinolinic acid (QA).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from quinolinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the NadC/ModD family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.19" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512963.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1988"/>
    <dbReference type="EnsemblBacteria" id="ABB32217">
        <property type="protein sequence ID" value="ABB32217"/>
        <property type="gene ID" value="Gmet_1988"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1988"/>
    <dbReference type="eggNOG" id="COG0157">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039622_0_1_7"/>
    <dbReference type="OMA" id="DMIMLKD"/>
    <dbReference type="OrthoDB" id="1718114at2"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00331"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004514">
        <property type="term" value="F:nicotinate-nucleotide diphosphorylase (carboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01572">
        <property type="entry name" value="QPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004393">
        <property type="entry name" value="NadC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027277">
        <property type="entry name" value="NadC/ModD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037128">
        <property type="entry name" value="Quinolinate_PRibosylTase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002638">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022412">
        <property type="entry name" value="Quinolinate_PRibosylTrfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32179">
        <property type="entry name" value="PTHR32179"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01729">
        <property type="entry name" value="QRPTase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02749">
        <property type="entry name" value="QRPTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006250">
        <property type="entry name" value="NadC_ModD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="SSF51690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00078">
        <property type="entry name" value="nadC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="QRPTase_N" evidence="12">
        <location>
            <begin position="16"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="QRPTase_C" evidence="11">
        <location>
            <begin position="108"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="128"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="236"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="10">
        <location>
            <begin position="257"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR006250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR006250-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB32217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="276" mass="29028" checksum="0D4A3066F39C17C1" modified="2005-11-22" version="1">MTGIDKIIENALMEDIHTGDITTLAVVPGSRPARARLIAKEPLILAGIDVAARVFTFLDASVCFEARHGDGARLAAGDLIAELTGDSALLLQGERVALNLLQRMCGTATLTARYVEAVAGTRARIVDTRKTTPGLRVLEKYAVRVGGGINHRTGLYDGVLIKENHIAAAGGISRAVSRARSYIPHTLKIEVETESIAEVTEALEAGADIIMLDNMDLPTMTEAVALIGGRALVEASGGVNLETVRGIAEAGVDIISVGALTHSARAMDISMLLEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U83</accession>
    <name>Q39U83_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glyco_hydro_114 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511882.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1962"/>
    <dbReference type="EnsemblBacteria" id="ABB32191">
        <property type="protein sequence ID" value="ABB32191"/>
        <property type="gene ID" value="Gmet_1962"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1962"/>
    <dbReference type="eggNOG" id="COG3868">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014516_0_0_7"/>
    <dbReference type="OMA" id="NQNENVY"/>
    <dbReference type="OrthoDB" id="95208at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="Glycoside_hydrolase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016925">
        <property type="entry name" value="UCP029570"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029570">
        <property type="entry name" value="UCP029570"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="SSF51445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyco_hydro_114" evidence="1">
        <location>
            <begin position="35"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="917" mass="102182" checksum="2DE872B211834937" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U99</accession>
    <name>Q39U99_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="8">1.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">gapA</name>
        <name evidence="10" type="ordered locus">Gmet_1946</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.-" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511897.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1946"/>
    <dbReference type="EnsemblBacteria" id="ABB32175">
        <property type="protein sequence ID" value="ABB32175"/>
        <property type="gene ID" value="Gmet_1946"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1946"/>
    <dbReference type="eggNOG" id="COG0057">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030140_0_2_7"/>
    <dbReference type="OMA" id="HETYKGE"/>
    <dbReference type="OrthoDB" id="944149at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43148">
        <property type="entry name" value="PTHR43148"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gp_dh_N" evidence="9">
        <location>
            <begin position="3"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="151"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glyceraldehyde 3-phosphate binding" evidence="4">
        <location>
            <begin position="210"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="331" mass="35511" checksum="8E9994EA6CC1F80B" modified="2005-11-22" version="1">MALRVAINGFGRIGRSVLRAAIKEKGIEFVAINDLTDAKTLAHLLKYDSVHGPFPGKVEAGNGEIIVNGKPIKILAVRNPEELPWKKEKIDVVLESTGLFTSREKAELHLKAGAKKIIISAPATNEDITIVMGVNSNLYDPKKHNIISNASCTTNCLAPVAKVLHETFGIEKGLVTTVHSYTNDQQILDLPHKDLRRARAAAMSMIPTSTGAAKAVALVLPELKGKLDGMAIRVPTPNVSVVDLVVTLSKKADADKVNAALKKASKGSLKGVLGFSEEPLVSIDFNGNPLSSIVDAGCTKVIEGNMVKVLSWYDNETGFSHRVVDLMKLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UC7</accession>
    <name>Q39UC7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1918</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511925.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1918"/>
    <dbReference type="EnsemblBacteria" id="ABB32147">
        <property type="protein sequence ID" value="ABB32147"/>
        <property type="gene ID" value="Gmet_1918"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1918"/>
    <dbReference type="eggNOG" id="COG2197">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_51_7"/>
    <dbReference type="OMA" id="RTQKMQA"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="11"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="285"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="528"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="4">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="650" mass="72923" checksum="EB94DDA6E405D81E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UH6</accession>
    <name>Q39UH6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NHL repeat domain lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511977.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1869"/>
    <dbReference type="EnsemblBacteria" id="ABB32098">
        <property type="protein sequence ID" value="ABB32098"/>
        <property type="gene ID" value="Gmet_1869"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1869"/>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008645_8_0_7"/>
    <dbReference type="OMA" id="MAWPPAP"/>
    <dbReference type="OrthoDB" id="966287at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001258">
        <property type="entry name" value="NHL_repeat"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51125">
        <property type="entry name" value="NHL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="121"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="165"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="217"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="258"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="repeat" description="NHL" evidence="2">
        <location>
            <begin position="305"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="353" mass="38915" checksum="C1964C3B8E21A7E4" modified="2005-11-22" version="1">MKSVLHSCSVRYLLYLLLGLILLGCAGVGTSPIALHDPAVDLVWPPPPNPPRIRFLREITGPEQIVPIQSKVGRLWQIVTGEERVMIPLMTPYGLASDGGSLLCVADSSTRVVQCYDLNNREVFYIRQAGDEPLASPVGVAFDSNGNVLVSDSINARVYVFSRQGEYLREFGNGETTFKRPAGIAVAGNGDVYVVDVLAHKLKKFDKDGHYRGEFPRDGSGEPLSLPSNVAVDREGNTYVTDSMNFTIKKYDRNGNFLRSFGEVGDAPGSFARPRGVAVDSELHVYAVDASFDNFQIFDQEGKLLLFVGKPGNGPGEFYLPSGLFIDKHDRIFVADTYNKRIQIFEYLRQGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UI0</accession>
    <name>Q39UI0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type II secretion system inner membrane protein PulF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pulF</name>
        <name evidence="9" type="ordered locus">Gmet_1865</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511981.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1865"/>
    <dbReference type="EnsemblBacteria" id="ABB32094">
        <property type="protein sequence ID" value="ABB32094"/>
        <property type="gene ID" value="Gmet_1865"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1865"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035032_2_1_7"/>
    <dbReference type="OMA" id="IGRWVEW"/>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="71"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="271"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="402" mass="44763" checksum="1202856B6B7F9D49" modified="2005-11-22" version="1">MALYTCKLGSTEGRIIVKEFEAVNPEILRVSLEEQGFFVFEVKKKPLQFLWERGGRNRRVDNKTLLTLNQELLVLIKAGLPIIQALDTILERFDRGQLADILKEVRENVKGGMALSDALEKYPKAFPHLYVASVRAGERTGDLPLTIRRYIAFLKRVEEVRKRFVSALVYPSILVTVATIAIAFLLVYVVPTFSQVYADAGSQLPLPTRILISFSSTLKHYILFVIALIGAVVMALRRWAATERGRFWVDDLRIRLPFIGEVFSKFAVASFTRTLATVIGSGIPIVESLKMSVGTLNNVVLERRLLQAVVKVEEGMSLSNAIESVKFMPPLALRMLGVGETTGSLEEMLSDISEYFESDIDARLHLLTTAIEPAIMIVMGLVVGVIIITMYLPVFKIAGTVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UJ7</accession>
    <name>EX7L_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Exodeoxyribonuclease 7 large subunit</fullName>
            <ecNumber evidence="1">3.1.11.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Exodeoxyribonuclease VII large subunit</fullName>
            <shortName evidence="1">Exonuclease VII large subunit</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">xseA</name>
        <name type="ordered locus">Gmet_1848</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.</text>
            <dbReference type="EC" id="3.1.11.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterooligomer composed of large and small subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XseA family.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511998.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UJ7"/>
    <dbReference type="STRING" id="269799.Gmet_1848"/>
    <dbReference type="EnsemblBacteria" id="ABB32077">
        <property type="protein sequence ID" value="ABB32077"/>
        <property type="gene ID" value="Gmet_1848"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1848"/>
    <dbReference type="eggNOG" id="COG1570">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_023625_3_1_7"/>
    <dbReference type="OMA" id="WPAVRFE"/>
    <dbReference type="OrthoDB" id="1371775at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009318">
        <property type="term" value="C:exodeoxyribonuclease VII complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008855">
        <property type="term" value="F:exodeoxyribonuclease VII activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04489">
        <property type="entry name" value="ExoVII_LU_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00378">
        <property type="entry name" value="Exonuc_7_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003753">
        <property type="entry name" value="Exonuc_VII_L"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020579">
        <property type="entry name" value="Exonuc_VII_lsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025824">
        <property type="entry name" value="OB-fold_nuc-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30008">
        <property type="entry name" value="PTHR30008"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02601">
        <property type="entry name" value="Exonuc_VII_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13742">
        <property type="entry name" value="tRNA_anti_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00237">
        <property type="entry name" value="xseA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000048773" description="Exodeoxyribonuclease 7 large subunit">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00378"/>
        </source>
    </evidence>
    <sequence length="453" mass="50756" checksum="0B92285798613B22" modified="2005-11-22" version="1">MELFPEKRILTVSQLTSLIRGVLEENFEHVWVEGEVSNLAMPASGHLYFTLKDAGAQIRCVMFRASARALKFRPRDGMGLIVRGRITVYEQRGDYQFLVEYLEPRGVGALQLAFIQLKEKLAKEGLFAEEHKRPIPSLPQRIGVVTSATGAAIHDILNVLNRRFANVEVLIRPVKVQGEGAADEIAEAIIDFNRYGAVDVMIVGRGGGSLEDLWAFNEEKVARAVHRSRIPIISAVGHEIDFTIADFVADLRAPTPSAAAELVVKSKEELASKVEFLRHRLIQTLRRILADAGGELESLSRALRDPTVLLGHLSQRLDDIFVRLERAIAGDLKDRGRMLEALKNHLRLRNPALKVERARERVIALSDKSEIALLRHVDRYREAAAVHSARLETLSPLGTLARGYSVALKLPERVPVKTFRQLALKDRLELLFHHGRAWCRVESLDEDASCSHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UQ9</accession>
    <name>Q39UQ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix DNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513319.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1784"/>
    <dbReference type="EnsemblBacteria" id="ABB32015">
        <property type="protein sequence ID" value="ABB32015"/>
        <property type="gene ID" value="Gmet_1784"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1784"/>
    <dbReference type="HOGENOM" id="CLU_2342747_0_0_7"/>
    <dbReference type="OMA" id="MITIDEF"/>
    <dbReference type="OrthoDB" id="2097795at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="SSF46955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="97" mass="11354" checksum="241BC0B35F17A968" modified="2005-11-22" version="1">MMPDSFYPPSLPEVLTVEQLAERLQVSRATLFSWMQRDILIAGRHYFKQGRVLRFLWSSELVMELVVGSEARKNRRPVTGPVSPHPRKQSNPINWEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UR0</accession>
    <name>Q39UR0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Integrase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1783"/>
    <dbReference type="EnsemblBacteria" id="ABB32014">
        <property type="protein sequence ID" value="ABB32014"/>
        <property type="gene ID" value="Gmet_1783"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1783"/>
    <dbReference type="eggNOG" id="COG0582">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_628157_0_0_7"/>
    <dbReference type="OMA" id="RTTHHEA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022000">
        <property type="entry name" value="Min27-like_integrase_DNA_bind"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12167">
        <property type="entry name" value="Arm-DNA-bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyr recombinase" evidence="3">
        <location>
            <begin position="220"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="452" mass="53230" checksum="67C67D93B452C73F" modified="2005-11-22" version="1">MKRTTHHEALLFDNEEKKQGTIIRKPGSRKLYILFYYFNRRVEKTTGLTDTKKNREKVRLWLDRIIERRDAGKLIFADAFPGAPEAEKAYFSKLEGWQYAPEPRDILFGSYLQEWYTNVWSHYPEGTKKDDYRLIIDYWLVPFFGEMTFFQISGVEIQKFIASLKWKKGAKKGQPLSKARAKNILIPLRTIWNDACDQYRWVLHNPFTNLKKHLPKTQPKRREGFRFDEWRDFLEHIDPWYQPVVELMILTGMINSEMAGLRRSDIRPDHILVQHTIVRGKEHDTPKTIYRIRKIPITQAIRKRLDILQQRSTGELLVTTKTGTIFRPANFLKDVWTKAGKASGITDKVPYSMRHSFAAWALTLRIDPNRLVRLMGHGSKKMVYEVYGDYIDGLEEDFWKILEYFGRDFVETKAKRPPHLLGYPGNIYPMVPGSYLQLEPEQQSPGLQLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V26</accession>
    <name>Q39V26_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_1667</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365856.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1667"/>
    <dbReference type="EnsemblBacteria" id="ABB31898">
        <property type="protein sequence ID" value="ABB31898"/>
        <property type="gene ID" value="Gmet_1667"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1667"/>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_133_5_7"/>
    <dbReference type="OMA" id="FPLIFEF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033417">
        <property type="entry name" value="CHASE8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17152">
        <property type="entry name" value="CHASE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="9">
        <location>
            <begin position="181"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="295"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="240"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="537" mass="59722" checksum="55F778772D0F5700" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V41</accession>
    <name>Q39V41_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Efflux pump, RND family, inner membrane protein, AcrB/AcrD/AcrF family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511411.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1652"/>
    <dbReference type="EnsemblBacteria" id="ABB31883">
        <property type="protein sequence ID" value="ABB31883"/>
        <property type="gene ID" value="Gmet_1652"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1652"/>
    <dbReference type="eggNOG" id="COG0841">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002755_1_2_7"/>
    <dbReference type="OMA" id="GQDFSIM"/>
    <dbReference type="OrthoDB" id="145346at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2090.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027463">
        <property type="entry name" value="AcrB_DN_DC_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001036">
        <property type="entry name" value="Acrflvin-R"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32063">
        <property type="entry name" value="PTHR32063"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00873">
        <property type="entry name" value="ACR_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00702">
        <property type="entry name" value="ACRIFLAVINRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82714">
        <property type="entry name" value="SSF82714"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="529"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="856"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="882"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="908"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="958"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="986"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1037" mass="113664" checksum="7062706445023C88" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V84</accession>
    <name>Q39V84_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hup-2</name>
        <name evidence="4" type="ordered locus">Gmet_1608</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511457.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1608"/>
    <dbReference type="EnsemblBacteria" id="ABB31840">
        <property type="protein sequence ID" value="ABB31840"/>
        <property type="gene ID" value="Gmet_1608"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1608"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_3_1_7"/>
    <dbReference type="OMA" id="TTVAKFK"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="96" mass="9933" checksum="2C9E5B470806F238" modified="2005-11-22" version="1">MTKAELVDAVAKSAELTKAAADKAVNGVIEAVTAALKKGDKVTLVGFGSFEVATRKARTGRNPQTGKEIKIAAAKVPKFRPGKALKDAVAGAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VB4</accession>
    <name>Q39VB4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenosine-specific tRNA nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ccaA</name>
        <name evidence="6" type="ordered locus">Gmet_1578</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511487.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1578"/>
    <dbReference type="EnsemblBacteria" id="ABB31810">
        <property type="protein sequence ID" value="ABB31810"/>
        <property type="gene ID" value="Gmet_1578"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1578"/>
    <dbReference type="eggNOG" id="COG0617">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0618">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3620">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015961_5_0_7"/>
    <dbReference type="OMA" id="ILCHTTA"/>
    <dbReference type="OrthoDB" id="2018439at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="SSF81301"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="315"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="377"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="880" mass="98645" checksum="10FCA43B1AF993E1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VC6</accession>
    <name>Q39VC6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">O-acetyl-L-homoserine sulfhydrylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">metY-3</name>
        <name evidence="4" type="ordered locus">Gmet_1566</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511499.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1566"/>
    <dbReference type="EnsemblBacteria" id="ABB31798">
        <property type="protein sequence ID" value="ABB31798"/>
        <property type="gene ID" value="Gmet_1566"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1566"/>
    <dbReference type="eggNOG" id="COG2873">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_4_0_7"/>
    <dbReference type="OMA" id="YGGMITF"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="414" mass="44456" checksum="D3A441A61283664A" modified="2005-11-22" version="1">MARDFQLDTLLIHGGLEPGPAGATTVPIVQSSSFAHETAEDLEDIFRGRKAGHVYTRINNPTTESLERRLALLEGGISAIATSSGMAAITLAVLSIVRCGDEILSSASLFGGTFSLFRDTLSNYGIATRFVDPSDLAAMRAAVTERTRLIFVETMGNPRLDVPDLAALAAIAREAGVPLVVDATVTTPVLGRVKELGADIIVHSTSKYINGTGSAIGGAIIDCGTFDWRRESYPHFEPYVKKFRQFAFSARARKLIHKDLGACPAPMNSYLLSEGIETMALRMERNCANAQRLAEFLAAHPKVAWVNYPGLTSSPWHETAKAQFGGRYGALLTFGLADKAAAFHCIDGLRLAKNLANIGDTKTLVIHPASTICADFGPEEKALMGVSEEMIRVSVGIEAIDDIIEDFAESLNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VE7</accession>
    <name>Q39VE7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">YHS/TRASH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511523.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1543"/>
    <dbReference type="EnsemblBacteria" id="ABB31777">
        <property type="protein sequence ID" value="ABB31777"/>
        <property type="gene ID" value="Gmet_1543"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1543"/>
    <dbReference type="eggNOG" id="COG3350">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1233588_0_0_7"/>
    <dbReference type="OMA" id="HPLYQKD"/>
    <dbReference type="OrthoDB" id="1619068at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007029">
        <property type="entry name" value="YHS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04945">
        <property type="entry name" value="YHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRASH" evidence="2">
        <location>
            <begin position="175"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="215" mass="24764" checksum="352CE59FC6EFB833" modified="2005-11-22" version="1">MEETGQLSEKIRKRLDRHLNELAERQKQIDSTMKEMLGQRERFAAAAHRLLESVVHPRMVELSHQFENAFVSDRHSGTDFYCSCEFAHTPRFPATVTLDIGLFPEETGEKVAIRSTLDILPTLMEYKRNDETTLPLEGSDEAVGRWVEEKILEFVDTYLRLETHPLYQKDYTVVDLVCGMPISATTAPCRIELHGRALYFCSEHCKDAYLKEKAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VE9</accession>
    <name>Q39VE9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">(R)-benzylsuccinate synthase, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">bssD</name>
        <name evidence="12" type="ordered locus">Gmet_1541</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the organic radical-activating enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511525.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1541"/>
    <dbReference type="EnsemblBacteria" id="ABB31775">
        <property type="protein sequence ID" value="ABB31775"/>
        <property type="gene ID" value="Gmet_1541"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1541"/>
    <dbReference type="eggNOG" id="COG1180">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058969_0_0_7"/>
    <dbReference type="OMA" id="ERKYQVM"/>
    <dbReference type="OrthoDB" id="1141206at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040074">
        <property type="entry name" value="BssD/PflA/YjjW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034457">
        <property type="entry name" value="Organic_radical-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012839">
        <property type="entry name" value="Organic_radical_activase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001989">
        <property type="entry name" value="Radical_activat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30352">
        <property type="entry name" value="PTHR30352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000371">
        <property type="entry name" value="PFL_act_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01118">
        <property type="entry name" value="activating_enzymes__group_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01087">
        <property type="entry name" value="RADICAL_ACTIVATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="15"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="46"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="10">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB31775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="348" mass="38794" checksum="3DAD962362F4F4D1" modified="2005-11-22" version="1">MLTPLITEIQRFCLHDGPGIRTTIFVKGCPLHCPWCHNPENINPKQEFYYHASKCSNCGQCLTACPSGVDNPEHDDCIGKTTDRSHCTSCFQCVSACRFGARETVGKFISIESIVQEAVSDRIFYQHSGGGVTVSGGEPLMYPEFTRDLTYRLKVKENVHVAIETSLFAEWHNIEPLLKYVDLFIVDIKTPDPQKHQHVIGGSLHKILSNLERLLEARATVRTHLPIIPGINDTSQDFEAYAEYLGQFANQLSGVDILPYHSYATGKYVQLGRSYQYLGVPDLPAQQLTPLVNALRQQGIREITLGGMVGSSPAVENVAGTRSLKPRRDYFSRPVYSPQGRGVVVTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VJ0</accession>
    <name>Q39VJ0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF4091 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511567.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1500"/>
    <dbReference type="EnsemblBacteria" id="ABB31734">
        <property type="protein sequence ID" value="ABB31734"/>
        <property type="gene ID" value="Gmet_1500"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1500"/>
    <dbReference type="eggNOG" id="ENOG5030C9N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_374603_0_0_7"/>
    <dbReference type="OMA" id="SRRWEAW"/>
    <dbReference type="OrthoDB" id="1742912at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025150">
        <property type="entry name" value="GH123_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13320">
        <property type="entry name" value="DUF4091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4091" evidence="1">
        <location>
            <begin position="659"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="741" mass="82431" checksum="479385B4BBF60D59" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VJ9</accession>
    <name>Q39VJ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent O-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511576.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1491"/>
    <dbReference type="EnsemblBacteria" id="ABB31725">
        <property type="protein sequence ID" value="ABB31725"/>
        <property type="gene ID" value="Gmet_1491"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1491"/>
    <dbReference type="eggNOG" id="COG4122">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1064608_0_0_7"/>
    <dbReference type="OMA" id="LNDAIIC"/>
    <dbReference type="OrthoDB" id="498900at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="261" mass="29994" checksum="038132310CF7C1B1" modified="2005-11-22" version="1">MLRLPFPVRNPVKYIHWSLHYDYSPTGCEVLPREIEQYFPLMRKLRSFNRNVPHSARIDERFPTVGWVSWDEATLLYNYGKMFNGKKMLEIGCWVGWSTVALALSGLKLTVVDPVLENMPQGDACRDSLARARLMNSVDLVPGFSPAKVEQLSRQGESWDIFFIDGNHDGDAPLQDARMCAELAPEDSIILLHDLIQPNIAEALLWLQNNGWQCGVHYTSMFMGVAWRGNRKPIQHTADPRINWQKLIDGSYPHLRSFQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VM0</accession>
    <name>Q39VM0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511598.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1470"/>
    <dbReference type="EnsemblBacteria" id="ABB31704">
        <property type="protein sequence ID" value="ABB31704"/>
        <property type="gene ID" value="Gmet_1470"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1470"/>
    <dbReference type="eggNOG" id="COG1366">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_177663_0_0_7"/>
    <dbReference type="OMA" id="GRINSMG"/>
    <dbReference type="OrthoDB" id="2016420at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13466">
        <property type="entry name" value="STAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SSF52091"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STAS" evidence="1">
        <location>
            <begin position="17"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="103" mass="11500" checksum="97B506FF587801C9" modified="2005-11-22" version="1">MGTDFRVVVTREGLTDVVRFYGNIDASAEQSVRELSARVNGPNVRCDFSDSGRINSMGIAFLLRFLKDLRDDKDARITIRGLSQVNAILFKMTGIFLLASLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VQ5</accession>
    <name>Q39VQ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SPOR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1435</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511633.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1435"/>
    <dbReference type="EnsemblBacteria" id="ABB31669">
        <property type="protein sequence ID" value="ABB31669"/>
        <property type="gene ID" value="Gmet_1435"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1435"/>
    <dbReference type="eggNOG" id="COG3087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1056728_0_0_7"/>
    <dbReference type="OMA" id="AHRMKEK"/>
    <dbReference type="OrthoDB" id="1741144at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042834">
        <property type="term" value="F:peptidoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007730">
        <property type="entry name" value="SPOR-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036680">
        <property type="entry name" value="SPOR-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05036">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110997">
        <property type="entry name" value="SSF110997"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51724">
        <property type="entry name" value="SPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="SPOR" evidence="3">
        <location>
            <begin position="191"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="267" mass="28255" checksum="8DC33CC2F7BE9919" modified="2005-11-22" version="1">MVLDYRERKPVNKNRPKSKPVGLFVIAFGLVAVCSFALGVLTDRFLLSPRSLKVENAQAPPSVAPKNGPQEQPSSTAKDSVTAKQGAAPALQEPSLTFYETLPKGGKIILGSGMNPKMPKVLTASPAKTATEALPKNDQVLPRQTEAVMVQKADKPAIPVSSPEKSAAADNAERPKAAGETAKEVSAKKTAVSKGKFSVQVVSARERKEADAIKSGLQEKGFAAYVVESVVPGKGTWYRVRVGKQMDQSAAAKLAKQLGKAAIIIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VT1</accession>
    <name>Q39VT1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1409"/>
    <dbReference type="EnsemblBacteria" id="ABB31643">
        <property type="protein sequence ID" value="ABB31643"/>
        <property type="gene ID" value="Gmet_1409"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1409"/>
    <dbReference type="HOGENOM" id="CLU_646835_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="424" mass="48932" checksum="387EEF343C2523E1" modified="2005-11-22" version="1">MNYENFAQLLEDRYSDFCQRWPLSSFVLDHYLRANLLQRPAIINQHRNYLQQTIRYGKIVDLLSRGFPKIIKNSDDKPSVLLAAPLIFSFPWLAKEVRDHNSSKLFTLNFFGLAKYYRQLRRMGYSYASLFDPLFKVEWSKALGQGMKTLTETDRMLSWSGWDNLELLTEQTVSGLTTRLSRLNCVSVVMLRDFFWYEAALILACKRAAIPCHVVAHGYPHCDPENSECFGYLPFRGDTLYCMSEESYHQLSPWVEDKHCYSVRLFSNTQKVNGEGILFISSSVEEVGLLDDKYRLAVYKGLQAAANKLNCRVTVRFRDDEQLDKKIKQAESFNFRWTVKNNISLDEDLKNNRYVFGFGSTALFLSHMLGHPTYNVSSYGSIDGVENIVPEKIPDVVSHVPVSLGFVDNRTTFADIFWKSLLHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VV2</accession>
    <name>Q39VV2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Riboflavin biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Riboflavin kinase</fullName>
                <ecNumber evidence="12">2.7.1.26</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">Flavokinase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">FMN adenylyltransferase</fullName>
                <ecNumber evidence="12">2.7.7.2</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="12">FAD pyrophosphorylase</fullName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="12">FAD synthase</fullName>
            </alternativeName>
        </domain>
    </protein>
    <gene>
        <name evidence="14" type="primary">ribF</name>
        <name evidence="14" type="ordered locus">Gmet_1388</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>ATP + FMN + H(+) = diphosphate + FAD</text>
            <dbReference type="Rhea" id="RHEA:17237"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="2.7.7.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>ATP + riboflavin = ADP + FMN + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14357"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57986"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 12">Cofactor biosynthesis; FAD biosynthesis; FAD from FMN: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">Cofactor biosynthesis; FMN biosynthesis; FMN from riboflavin (ATP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the ribF family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.26" evidence="12"/>
    <dbReference type="EC" id="2.7.7.2" evidence="12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513120.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1388"/>
    <dbReference type="EnsemblBacteria" id="ABB31622">
        <property type="protein sequence ID" value="ABB31622"/>
        <property type="gene ID" value="Gmet_1388"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1388"/>
    <dbReference type="eggNOG" id="COG0196">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048437_0_0_7"/>
    <dbReference type="OMA" id="HRGHQAI"/>
    <dbReference type="OrthoDB" id="1504821at2"/>
    <dbReference type="UniPathway" id="UPA00276">
        <property type="reaction ID" value="UER00406"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00277">
        <property type="reaction ID" value="UER00407"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003919">
        <property type="term" value="F:FMN adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008531">
        <property type="term" value="F:riboflavin kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006747">
        <property type="term" value="P:FAD biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009398">
        <property type="term" value="P:FMN biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02064">
        <property type="entry name" value="FAD_synthetase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015864">
        <property type="entry name" value="FAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023468">
        <property type="entry name" value="Riboflavin_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002606">
        <property type="entry name" value="Riboflavin_kinase_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015865">
        <property type="entry name" value="Riboflavin_kinase_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023465">
        <property type="entry name" value="Riboflavin_kinase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22749">
        <property type="entry name" value="PTHR22749"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06574">
        <property type="entry name" value="FAD_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01687">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004491">
        <property type="entry name" value="FAD_Synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00904">
        <property type="entry name" value="Flavokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82114">
        <property type="entry name" value="SSF82114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00083">
        <property type="entry name" value="ribF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="6 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 12" id="KW-0288">FMN</keyword>
    <keyword evidence="12 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Flavokinase" evidence="13">
        <location>
            <begin position="183"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR004491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB31622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="322" mass="35831" checksum="A079BC056EF7F481" modified="2005-11-22" version="1">MHIFRSIEEIAEKLPNAVVTIGNFDGVHLGHREIFRRVKREAAAIGGVSLVITFIPHPIKMLGVKKGFRLISTYAEKETLLEASGIDYLLIIPFTGEFASISAERFVRDILVGTIGVRKLIIGYDYAFGKNRQGDVTMLRRMGEELGFTVDMLEPITSGDLVYSSTAVRQMVAEGDVRGVVRLLGRHFSVGGTVVHGRQRGKGLGFPTANLQTDKELIPKPGVYAVKVKVEETTYDGACNIGDNPTFGNGSLSIEVFIFDFDGDIYGREVRLYFVDRIRDEVTFPNPQVLQEAIARDVARCRELLRDVAIIEYQEYLAEEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VW8</accession>
    <name>Q39VW8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TPM_phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1372</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513136.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1372"/>
    <dbReference type="EnsemblBacteria" id="ABB31606">
        <property type="protein sequence ID" value="ABB31606"/>
        <property type="gene ID" value="Gmet_1372"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1372"/>
    <dbReference type="eggNOG" id="COG1512">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035211_2_3_7"/>
    <dbReference type="OMA" id="RAWGIGQ"/>
    <dbReference type="OrthoDB" id="1720318at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007621">
        <property type="entry name" value="TPM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04536">
        <property type="entry name" value="TPM_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="TPM_phosphatase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="290" mass="29291" checksum="DD5F6C52F4200318" modified="2005-11-22" version="1">MIRLFLAILIVLLPALASALDVPQLRGYVNDYAGILSAGTVRQLEESLAGFERSDSTQIVVLTVPSLEGDDLETFSIRVAEAWQIGHKGKDNGAILLVAKAERKVRIEVGRGLEGTLTDLVSGRIIRGEITPRFKQGDFDGGVTAGVTAIMAVVKGEYAATPRDLRQGKRSAPPVAALLFFLGVACIFLGALSRVFGGIAGAAGLPLVASLTFPGLGIIVLAGLAVAGFLLGIFLTFLFGGGGRGGGGTWGGPFYGGGFGGGFGGGWSSGGGGFSGGGGGFGGGGASGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VW9</accession>
    <name>Q39VW9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LemA family lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1371</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LemA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513137.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1371"/>
    <dbReference type="EnsemblBacteria" id="ABB31605">
        <property type="protein sequence ID" value="ABB31605"/>
        <property type="gene ID" value="Gmet_1371"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1371"/>
    <dbReference type="eggNOG" id="COG1704">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056714_0_0_7"/>
    <dbReference type="OMA" id="VETQYQR"/>
    <dbReference type="OrthoDB" id="1573349at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023353">
        <property type="entry name" value="LemA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007156">
        <property type="entry name" value="MamQ_LemA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34478">
        <property type="entry name" value="PTHR34478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04011">
        <property type="entry name" value="LemA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140478">
        <property type="entry name" value="SSF140478"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223197" evidence="6">
        <location>
            <begin position="21"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="194" mass="21544" checksum="9EDD738BE10DCDA4" modified="2005-11-22" version="1">MKRIVMLVLAALTLSGLTGCGYNVMQAKEEAVLAAWGDVEAAYQRRADLVPNLVEVVKGYAKHEADTLTAVTEARAKVGSMQVTKEALSNPETFAKFQQAQGELSGALSRLMVVVERYPDLKANQNFLDLQNQLEGTENRINVARTRYNKSVQDFNTSIRTFPNSLTNKLLLHLERKEPFKAEEGAKTAPKVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W67</accession>
    <name>Q39W67_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1271</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the MlaE permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365794.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1271"/>
    <dbReference type="EnsemblBacteria" id="ABB31507">
        <property type="protein sequence ID" value="ABB31507"/>
        <property type="gene ID" value="Gmet_1271"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1271"/>
    <dbReference type="eggNOG" id="COG0767">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045686_1_1_7"/>
    <dbReference type="OMA" id="PNALTRY"/>
    <dbReference type="OrthoDB" id="1253502at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003453">
        <property type="entry name" value="ABC_MlaE_Proteobac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030802">
        <property type="entry name" value="Permease_MalE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30188">
        <property type="entry name" value="PTHR30188"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02405">
        <property type="entry name" value="MlaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00056">
        <property type="entry name" value="TIGR00056"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="255" mass="27678" checksum="A768153DC4E734B3" modified="2005-11-22" version="1">MFERVGKRVIAFNEIVGEMVMLLCQTVWFFREAPRNILSIFTQMSIIGYETLPMASVMAFFVGMVLALQTGAELQKYGTQNIIGGIVGLSMVRELGPVMTSFLVAGRAGSAMAAEIGVMKVYEEIDALKTLDINPVRYLAMPRLIACLICVPALVIYADFVGILGGALLSHLHPKIFISYSTYYDSLNTALKLKEIGAGLLKATVFGCIIGVVSCYTGFKTTGGARGIAQSTTRAVVLSFMLILAADYFLTRLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WB9</accession>
    <name>Q39WB9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1218</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512151.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1218"/>
    <dbReference type="EnsemblBacteria" id="ABB31455">
        <property type="protein sequence ID" value="ABB31455"/>
        <property type="gene ID" value="Gmet_1218"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1218"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_313703_0_0_7"/>
    <dbReference type="OMA" id="VRITMAL"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="39"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="113"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="345"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="485"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="8">
        <location>
            <begin position="607"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="722"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="651"/>
            <end position="703"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="933" mass="105478" checksum="F3DBA35C33BC8107" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WF0</accession>
    <name>Q39WF0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1187</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512183.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1187"/>
    <dbReference type="EnsemblBacteria" id="ABB31424">
        <property type="protein sequence ID" value="ABB31424"/>
        <property type="gene ID" value="Gmet_1187"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1187"/>
    <dbReference type="HOGENOM" id="CLU_2897767_0_0_7"/>
    <dbReference type="OMA" id="ECWWAET"/>
    <dbReference type="OrthoDB" id="2023453at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="65" mass="7321" checksum="E2F8DAADC3A2A3C3" modified="2005-11-22" version="1">MYVARDKDKQLYLFKDLPLRGNECWWAESGVDGTYLRLDNALFPEVTWESAPLPVSLVSASEGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WK4</accession>
    <name>Q39WK4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pvc16_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513396.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1132"/>
    <dbReference type="EnsemblBacteria" id="ABB31370">
        <property type="protein sequence ID" value="ABB31370"/>
        <property type="gene ID" value="Gmet_1132"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1132"/>
    <dbReference type="eggNOG" id="ENOG502ZB25">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_822945_0_0_7"/>
    <dbReference type="OMA" id="STQGETH"/>
    <dbReference type="OrthoDB" id="1522990at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025351">
        <property type="entry name" value="Pvc16_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14065">
        <property type="entry name" value="Pvc16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pvc16_N" evidence="1">
        <location>
            <begin position="11"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="344" mass="36464" checksum="9D4323DD2F5975C9" modified="2005-11-22" version="1">MALPRSSLSQVCRAIADFVSVGLDASANSIQVMIGSPASAAPATADTNHRVNLFFYRVEPAGFFTGDTPGDPWWVRLHCLVTGFGLDEEQISAGENDLRLLGEVMRLFHETPVQSALTVDDETFRLQVVFHPLGADELNHIWSTQGDVSYRPSIAYEMALAPVLPAERRPESPLVGRIGTEVRAVPAARTSPFGGAAAAPPVPRTTVDASRPDWPPVISFVLDGGTCAQSLLFAHGSQELADFTPQVWVAGEPAAPVTLAWQRWTSTGGWEDVADPTATMATDLVLDPAAAGDADSVEVALPEELVSDGGQAVLYAERSFVRGADGVTVTVRSNPLLVTVHGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="45" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WL6</accession>
    <name>Q39WL6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1120"/>
    <dbReference type="EnsemblBacteria" id="ABB31358">
        <property type="protein sequence ID" value="ABB31358"/>
        <property type="gene ID" value="Gmet_1120"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1120"/>
    <dbReference type="HOGENOM" id="CLU_2553421_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="82" mass="9150" checksum="E7D3A4DE19F99049" modified="2005-11-22" version="1">MSTLLFLIKKYIVTESQREKVSGSEKVVFYFEETAGDQVRAQGFSHRLHLGWHYCSPLPAFCAWAEAVPGEGATSTGKKEPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WP9</accession>
    <name>Q39WP9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Selenium metabolism protein YedF, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">yedF</name>
        <name evidence="3" type="ordered locus">Gmet_1085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfur carrier protein TusA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513741.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1085"/>
    <dbReference type="DNASU" id="3741292"/>
    <dbReference type="EnsemblBacteria" id="ABB31325">
        <property type="protein sequence ID" value="ABB31325"/>
        <property type="gene ID" value="Gmet_1085"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1085"/>
    <dbReference type="eggNOG" id="COG0425">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097491_0_0_7"/>
    <dbReference type="OMA" id="CGTCLNF"/>
    <dbReference type="OrthoDB" id="1385159at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027396">
        <property type="entry name" value="DsrEFH-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019870">
        <property type="entry name" value="Se_metab_YedF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001455">
        <property type="entry name" value="TusA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036868">
        <property type="entry name" value="TusA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01206">
        <property type="entry name" value="TusA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64307">
        <property type="entry name" value="SSF64307"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75169">
        <property type="entry name" value="SSF75169"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03527">
        <property type="entry name" value="selenium_YedF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UPF0033" evidence="2">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="196" mass="20785" checksum="BF676814069605F3" modified="2005-11-22" version="1">MKIIDCRNMACPAPVVTTKRALEEAGGETVQVLVDPGAPRENVIRFAENRGFAVSEVEADNGFALTITSPGSAPVEPVRTVAGKGGKTVMLVASDRLGDGPEELGRLLMKNFIITLLDLAELPDRMLFVNTGVLLTTEGSEVLEALQSLGNRGVEVLSCGVCLDFFHRKEKLVAGSVTNMFTIAESLLGAGSVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WQ5</accession>
    <name>Q39WQ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Scaffold protein CheW associated with MCPs of class 36H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cheW36H</name>
        <name evidence="2" type="ordered locus">Gmet_1079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513735.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1079"/>
    <dbReference type="EnsemblBacteria" id="ABB31319">
        <property type="protein sequence ID" value="ABB31319"/>
        <property type="gene ID" value="Gmet_1079"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1079"/>
    <dbReference type="eggNOG" id="COG0835">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048995_1_0_7"/>
    <dbReference type="OMA" id="CVTRIAN"/>
    <dbReference type="OrthoDB" id="1711729at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039315">
        <property type="entry name" value="CheW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22617">
        <property type="entry name" value="PTHR22617"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheW-like" evidence="1">
        <location>
            <begin position="9"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="156" mass="17274" checksum="2357277D529C8AE2" modified="2005-11-22" version="1">MDTPERTIPHEYLTFTLGAEEYGIDILKVQEIRGYDAVTRIANSPEFLKGVINLRGVIVPIVDMRIRFNLGTPTYDEFTVVIIMNVLNRVIGMVVDGVSDVVALEPEQIRPAPEMGSALDTRYLTGLGTVNGQMLILMDIEKLLSSSEMQLMDSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WY2</accession>
    <name>Q39WY2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514693.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1000"/>
    <dbReference type="EnsemblBacteria" id="ABB31242">
        <property type="protein sequence ID" value="ABB31242"/>
        <property type="gene ID" value="Gmet_1000"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1000"/>
    <dbReference type="eggNOG" id="COG1011">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074041_0_0_7"/>
    <dbReference type="OMA" id="DDTLWVN"/>
    <dbReference type="OrthoDB" id="1204073at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="SSF56784"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="237" mass="26937" checksum="815F060F285ADFEF" modified="2005-11-22" version="1">MIEIIAFDGDDTLWHEAPLFQSSVMKFQELLAGYHDNDKLHDLISDKAVSNLKHFGYGIKGFTLSLIETALDVTEDRIPAEKIRNILELGKEMMNAPIDLLDGAKETVDLLSRTYRLILLTKGDLFHQEAKVARSGLGNYFHQLEIVAKKDDHIYERILNKYGIAGDKFMMVGNSVPSDILPALKVGAYAAHIPYHLEWAHETVSDEKRLELQEHQRCFLLETLHSLPEVLNQLSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X49</accession>
    <name>Q39X49_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dystroglycan-type cadherin-like domain repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0933"/>
    <dbReference type="EnsemblBacteria" id="ABB31175">
        <property type="protein sequence ID" value="ABB31175"/>
        <property type="gene ID" value="Gmet_0933"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0933"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2373">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3391">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_227677_0_0_7"/>
    <dbReference type="OMA" id="DTDCNAC"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007156">
        <property type="term" value="P:homophilic cell adhesion via plasma membrane adhesion molecules"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002126">
        <property type="entry name" value="Cadherin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043772">
        <property type="entry name" value="MBG_3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18887">
        <property type="entry name" value="MBG_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="SSF49313"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50268">
        <property type="entry name" value="CADHERIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223237" evidence="2">
        <location>
            <begin position="29"/>
            <end position="2636"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="2210"/>
            <end position="2304"/>
        </location>
    </feature>
    <feature type="domain" description="Cadherin" evidence="3">
        <location>
            <begin position="2389"/>
            <end position="2492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2450"/>
            <end position="2472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="2636" mass="264903" checksum="8A60C39324292B84" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XD6</accession>
    <name>Q39XD6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Helix-turn-helix transcriptional regulator, ArsR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512990.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0846"/>
    <dbReference type="EnsemblBacteria" id="ABB31088">
        <property type="protein sequence ID" value="ABB31088"/>
        <property type="gene ID" value="Gmet_0846"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0846"/>
    <dbReference type="eggNOG" id="COG0640">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_097806_6_2_7"/>
    <dbReference type="OMA" id="IWECLGL"/>
    <dbReference type="OrthoDB" id="1772343at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00090">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011991">
        <property type="entry name" value="ArsR-like_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001845">
        <property type="entry name" value="HTH_ArsR_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01022">
        <property type="entry name" value="HTH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00778">
        <property type="entry name" value="HTHARSR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00418">
        <property type="entry name" value="HTH_ARSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50987">
        <property type="entry name" value="HTH_ARSR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH arsR-type" evidence="1">
        <location>
            <begin position="5"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="91" mass="10201" checksum="99F586FE93DF48D5" modified="2005-11-22" version="1">MDFDISRNFSEEAEIFKVLGHPIRLKIVAGLCTRECNVKHIWECLGLPQATVSQHLALLKNKGIIEGKRDGVEVHYSVVHPLAKKLIEVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XH7</accession>
    <name>Q39XH7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Flavoredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514392.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0805"/>
    <dbReference type="EnsemblBacteria" id="ABB31047">
        <property type="protein sequence ID" value="ABB31047"/>
        <property type="gene ID" value="Gmet_0805"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0805"/>
    <dbReference type="eggNOG" id="COG1853">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059021_5_5_7"/>
    <dbReference type="OMA" id="ACIGPWD"/>
    <dbReference type="OrthoDB" id="1681849at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016646">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin_Reduct" evidence="1">
        <location>
            <begin position="9"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="188" mass="19957" checksum="4AF6BF7F54C191C3" modified="2005-11-22" version="1">MKQSLGAKTLLFPAPVLMVGTYDHEGKPNLMNAAWGGICCSQPPCVAVSLRKATYSYASIVERKAFTIGTPSEAAMKAADYVGIVSGRDTDKFAATGLTPVKSELVDAPYAAEFPFALECRLLHTLEIGLHTLFVGEIVDVKADAEVLGDDGLPDILKLKPLVFDTSHRGYHGVGPLLGKALAVGKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XI2</accession>
    <name>Q39XI2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase of ISGme5, ISL3 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0443</name>
        <name evidence="5" type="ordered locus">Gmet_0800</name>
        <name evidence="6" type="ordered locus">Gmet_1977</name>
        <name evidence="7" type="ordered locus">Gmet_2166</name>
        <name evidence="8" type="ordered locus">Gmet_2284</name>
        <name evidence="9" type="ordered locus">Gmet_2376</name>
        <name evidence="10" type="ordered locus">Gmet_2840</name>
        <name evidence="11" type="ordered locus">Gmet_3102</name>
        <name evidence="12" type="ordered locus">Gmet_3396</name>
    </gene>
    <organism evidence="5 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="5">GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="5">GS-15</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365668.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0443"/>
    <dbReference type="EnsemblBacteria" id="ABB30686">
        <property type="protein sequence ID" value="ABB30686"/>
        <property type="gene ID" value="Gmet_0443"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31042">
        <property type="protein sequence ID" value="ABB31042"/>
        <property type="gene ID" value="Gmet_0800"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32206">
        <property type="protein sequence ID" value="ABB32206"/>
        <property type="gene ID" value="Gmet_1977"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32395">
        <property type="protein sequence ID" value="ABB32395"/>
        <property type="gene ID" value="Gmet_2166"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32509">
        <property type="protein sequence ID" value="ABB32509"/>
        <property type="gene ID" value="Gmet_2284"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32601">
        <property type="protein sequence ID" value="ABB32601"/>
        <property type="gene ID" value="Gmet_2376"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33058">
        <property type="protein sequence ID" value="ABB33058"/>
        <property type="gene ID" value="Gmet_2840"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33316">
        <property type="protein sequence ID" value="ABB33316"/>
        <property type="gene ID" value="Gmet_3102"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33608">
        <property type="protein sequence ID" value="ABB33608"/>
        <property type="gene ID" value="Gmet_3396"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0443"/>
    <dbReference type="KEGG" id="gme:Gmet_0800"/>
    <dbReference type="KEGG" id="gme:Gmet_1977"/>
    <dbReference type="KEGG" id="gme:Gmet_2166"/>
    <dbReference type="KEGG" id="gme:Gmet_2284"/>
    <dbReference type="KEGG" id="gme:Gmet_2376"/>
    <dbReference type="KEGG" id="gme:Gmet_2840"/>
    <dbReference type="KEGG" id="gme:Gmet_3102"/>
    <dbReference type="KEGG" id="gme:Gmet_3396"/>
    <dbReference type="eggNOG" id="COG3464">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041900_0_2_7"/>
    <dbReference type="OMA" id="EPYARIT"/>
    <dbReference type="OrthoDB" id="1128314at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002560">
        <property type="entry name" value="Transposase_DDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032877">
        <property type="entry name" value="Transposase_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029261">
        <property type="entry name" value="Transposase_Znf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01610">
        <property type="entry name" value="DDE_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13542">
        <property type="entry name" value="HTH_Tnp_ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14690">
        <property type="entry name" value="zf-ISL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-ISL3" evidence="3">
        <location>
            <begin position="44"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="HTH_Tnp_ISL3" evidence="2">
        <location>
            <begin position="93"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="DDE_Tnp_ISL3" evidence="1">
        <location>
            <begin position="158"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="407" mass="46772" checksum="22AF3C5D860C0B4E" modified="2005-11-22" version="1">MSYSDVIAIAGGWEGYRVAGTRTIVTGDAKRIEVELIALSQDEMVCGSCGGRCTSVHETTKRVIRDLPILDAQTYLIVHRRRLLCPQCGPTLERLSWLAKYARVTRRLAESVARLCGVVSVKHVAQYLGLSWDQVKEIDKRSLTERVGTVDLSNIEVLGMDEFALHKGHRYATVIIEPYRKEVLWIGKGRSRESIRPFFTQLGPHGCKRLKAVVMDMNASYEEEIKQHSPQADIVYDLFHVVAKYGREVIDRVRVDEANRLKEDKKARKVVKTSRWLLLRNSENVKGDDMLRLQELLEANRSLLTVYLLKDDLKQLWKFTCIEEAGLFWEQWHQRAMESGIPPLILFARRLKGYLQGILNHCLWPLHTGILEGINNKIKVIKRMAYGFRDHEYFFLKIRAAFPGIPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XJ9</accession>
    <name>Q39XJ9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PEP motif-containing outer membrane channel, putative exosortase substrate</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513528.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31025">
        <property type="protein sequence ID" value="ABB31025"/>
        <property type="gene ID" value="Gmet_0783"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0783"/>
    <dbReference type="HOGENOM" id="CLU_773300_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013424">
        <property type="entry name" value="PEP_exosort_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07589">
        <property type="entry name" value="PEP-CTERM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02595">
        <property type="entry name" value="PEP_exosort"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PEP-CTERM" evidence="1">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="358" mass="38087" checksum="40D7A029C5DC22A0" modified="2005-11-22" version="1">MAKRIRSGFGAGAAALLILLCQSAQVFGYAEYYTYGDYNPTSSSNPGYYREYNDSAARVSFSRPVGDMLSIGDNKSYATSSGYADAGKLRMGISASAVSRPQNNYFTSSYIATTATNRATILPGTSGLSAGDTTRLQLTMKLDGTLGADARSYPGKGWAHAEFDAGFAISDSSVTICGPGEVGCWSPQLAFFGASGEAEAYDVYGPGWGYNYSNHWSESWSYGSNITPETSHDLAGGTKEQGVGMYYDWGRSFDTGYLTLVFEAIVGHTLDIESYLEAYVDANNDAESFADFDKTLAFGLTPTNGVVLGWEIGNPVPPAENAVPPGPEAVPEPSSMLLVGAGLVSLLGLHRVRARKEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XK9</accession>
    <name>Q39XK9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Diguanylate cyclase, CAP_ED domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513518.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0773"/>
    <dbReference type="EnsemblBacteria" id="ABB31015">
        <property type="protein sequence ID" value="ABB31015"/>
        <property type="gene ID" value="Gmet_0773"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0773"/>
    <dbReference type="eggNOG" id="COG0664">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_5_7"/>
    <dbReference type="OMA" id="AGDYALC"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="SSF51206"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="1">
        <location>
            <begin position="187"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="318" mass="34504" checksum="3D3CA3773D266858" modified="2005-11-22" version="1">MTHDSLFSTAELETVPLFRFVPLECIEGILAHCTAQELPRGERFEPDGPLDRSLSVLLSGRLALHYDVRETNDPLFLEPGDIIGETFSAGEPGVPCLLVAAEPCRVLVMEEDLIWSLAQASHAAACNLLGILLRRRHDPSRESFAGTAREYALHDQSIVDPLTGFQTRRWLEGVLERQAGRAASSGKPLSLMMIDIDHFRAFNEEHGRIGGDRALHAVSKALRNYLRPTEVVARYGGDTFAILLPETGVATARMIAERLRQRLTNTVIDIHDGRMLPPLTISVGVAEAAVGSDSLTLLRGALEALDAAKASGGNAVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XS7</accession>
    <name>Q39XS7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514097.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0705"/>
    <dbReference type="EnsemblBacteria" id="ABB30947">
        <property type="protein sequence ID" value="ABB30947"/>
        <property type="gene ID" value="Gmet_0705"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0705"/>
    <dbReference type="HOGENOM" id="CLU_794005_0_0_7"/>
    <dbReference type="OMA" id="IWFAFIL"/>
    <dbReference type="OrthoDB" id="520713at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="349" mass="38906" checksum="0809D019E4C8EB4E" modified="2005-11-22" version="1">MPMSIKNAILLFVVVALCAAFSMRIFQGLDEMMGDQYWVVDTTQGDHGWYAMGLLPHVKLMAKDVVKAVNTDADKSNNYEIYAQAGDFAGNSVYGICYGIPLIMYLIWFAFILGFPDRVDPYLLPRKIFTLAVITCCSIVVNLFLMRITADFATDPMSRIANVAGNHASLLFHNAGIWFAILFSALGTHAHSAQETSAPDSRQWQTQANEKFSWMFILLGAVTVLELFLVKGKLALPDAAVDYSVWLIWVVIFMRMFGFSPKYWFKRGRGLAIMFVGTALTLVAFYFLERFTGNLGAGFASPILAKALGVENQNIGLSLMISIYLIFWMEFSAAIRMNGPAKSAVEQKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y41</accession>
    <name>Q39Y41_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30833.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0590"/>
    <dbReference type="EnsemblBacteria" id="ABB30833">
        <property type="protein sequence ID" value="ABB30833"/>
        <property type="gene ID" value="Gmet_0590"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0590"/>
    <dbReference type="HOGENOM" id="CLU_1041148_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008969">
        <property type="entry name" value="CarboxyPept-like_regulatory"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49464">
        <property type="entry name" value="SSF49464"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223428" evidence="1">
        <location>
            <begin position="23"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30833.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="28105" checksum="B317D8732897F23E" modified="2012-10-31" version="2">MKNKMIGFFLMVFFCSIQAVFAADDTGTITGKWITKEYGPMTDAQVLLFNVAKGPPPAGHKYLRTPDMGTPVDQEGGFRVQAPAGRYYLVMLKRVDPNSAGPPREGDPQYYARDKKGKPKEFVVKAGKTTNIGTITEAVPYRKGVAAVKDGTTGIEGTVTDKQGQPVAGIRVFAYEAAEMQGMPRYASNETGADGKYVLVLTGKGTYFLKARTHYGGGKPAEGEFLGAYGSGPVVVDGGQLRQGIDIQVTRFSTQQRKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y46</accession>
    <name>Q39Y46_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ADP-heptose--lipopolysaccharide heptosyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0585</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512283.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0585"/>
    <dbReference type="CAZy" id="GT9">
        <property type="family name" value="Glycosyltransferase Family 9"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30828">
        <property type="protein sequence ID" value="ABB30828"/>
        <property type="gene ID" value="Gmet_0585"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0585"/>
    <dbReference type="eggNOG" id="COG0859">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038371_3_0_7"/>
    <dbReference type="OMA" id="ILPIRAW"/>
    <dbReference type="OrthoDB" id="1068323at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03789">
        <property type="entry name" value="GT9_LPS_heptosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002201">
        <property type="entry name" value="Glyco_trans_9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01075">
        <property type="entry name" value="Glyco_transf_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="406" mass="43876" checksum="06F5B44BDACE67E1" modified="2005-11-22" version="1">MNWKLIRIIDVWLGIPILFGIFVAGRLFGKRQPQRPATVRRILLIKFWGIGNLFMMLPSVQALRAAHPAAAIDVLSLDSNRDAIRACGVFDGVATITTAGPLRFLLSWRRAVALLRRNRYDIIIDFEQFARFSALVAGQIGAAEIIGFRTEGQHRSLNFTVQVPYDNAIHVTRSFHALVAAAGAAPVDRLPAAGISGSENLRERGKELLAQIGIGPDELCVVMHAGTSGNFSERRWPPERFSSLADTLHAGHNARTIFTGAAEEAFLTREAARHLHRPLSALDLGGKLKFRDYLALIAAADLVVSADTAAVHMASAVGTPVVGLYGPNTPRLYGPWGRGGVAVCQGLDCSPCITNFNAKLHVCRHPAGRGACMGAIGVEDVAAAIRRNFLEPDAPFLLTRLSGGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y53</accession>
    <name>Q39Y53_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ResB-like family cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0578</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0578"/>
    <dbReference type="EnsemblBacteria" id="ABB30821">
        <property type="protein sequence ID" value="ABB30821"/>
        <property type="gene ID" value="Gmet_0578"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0578"/>
    <dbReference type="eggNOG" id="COG1333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_625236_0_0_7"/>
    <dbReference type="OMA" id="CERFRSV"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="8"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="438" mass="48093" checksum="3098D56E9117F60F" modified="2005-11-22" version="1">MQRLASRRVSLTLILMLLCICVIGALVPQKSTLEPESYAAWVAAGGVHDLWLKLGFTRIFSTWYFLAVMILFFASTLAATIIRARGLLRREKPEPSAAAMVGEPFSTTVSGVPLEKLKLRVSGFSWHEGLCADGRYLAGTRFGIARWSVVSLHLSLLLLILGVLASHATYFRGYMKLGVGQSEQLDESGFFQQDRGMFAPALPQGLKITLLSFDNRYREAGYLPDIAADFLLEGAAGGPLRTRLLRSGMVSYGGLDLYLSVRRGFGVILHTVRRDGGRASGYVNFNFPEGGKTPRVQAEIPGSNAQVDVEFLSRNRRYDDLAGIAAPAIRMRFMRNGGVVAERLLRPGEGTVVEGISYTFGKIDYWCDIAATRDPGIYLIYAGFAAAALTLVLFAFFPTAEIRLLGAGGTDSVHVAVRCERFRSVAERILEQITEERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y63</accession>
    <name>Q39Y63_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ABC transporter, periplasmic substrate-binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0568</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512265.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0568"/>
    <dbReference type="EnsemblBacteria" id="ABB30811">
        <property type="protein sequence ID" value="ABB30811"/>
        <property type="gene ID" value="Gmet_0568"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0568"/>
    <dbReference type="eggNOG" id="COG3221">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051472_5_0_7"/>
    <dbReference type="OMA" id="FRGQIIC"/>
    <dbReference type="OrthoDB" id="988224at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="301" mass="33369" checksum="E99FE63DADACD373" modified="2005-11-22" version="1">MIRSTFRRFLLLFLPLLLLAGCKGEGSRPVVKIGYMLCNNEQETMSRFLPLTRYLSDKCGVDFVAVPVDTHDFEKRFKAGEFTFTHSNSLIYVILHENEGVQLLASEKRGKFGARSAGALIARKGSGIEKLADIRGKRLAFGPMLAPTGYLAEYDLMLSAGINPEHDLGTYSIPPGSYKHEKLIYGVLYGQYDVAAAPILDLETMTREGKIAADDFVILAQSKPVPYCTFGVAKGADPALVKKVKEALLALKPADTAEVDGERIKVLKAAWIDGYEELLDSDYDSIREMAKRVNMPPYQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y69</accession>
    <name>Q39Y69_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ResB-like family cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0562</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0562"/>
    <dbReference type="EnsemblBacteria" id="ABB30805">
        <property type="protein sequence ID" value="ABB30805"/>
        <property type="gene ID" value="Gmet_0562"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0562"/>
    <dbReference type="eggNOG" id="COG1333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_899433_0_0_7"/>
    <dbReference type="OMA" id="INREFYP"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="314" mass="34386" checksum="7FEAF9AF53F9B03E" modified="2005-11-22" version="1">MPVTQPDLLKRTVRFLASTELAVILFLATALLAIPGTFTDSRALYVHPVFLCLLGGLALNLVLCTVRRFRSISVPVLILHLGVLVVCGGVMARAFGYVATVNIYEGTTVDTVYRWDLKRDVPLGAALTIKRINREYYPIPVKVGVLRGTVKDSLHTLKTGDSFAAGPYRVTADSLQFPAEVLKLSVFQDGRLIGTCDTGGLRALPANFPYDFKLVAFQNPVMKRLWVDLALTRDSAPAVSGTAAVNDPFIWNGLYFYNTQVDVDKVGTPFAGIQVVRDPGRPCVFAGFAIMGFGSILSCARRLRKEQRKKTVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YB9</accession>
    <name>Q39YB9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Molybdate ABC transporter, periplasmic molybdate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">modA</name>
        <name evidence="5" type="ordered locus">Gmet_0512</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial solute-binding protein ModA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512208.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0512"/>
    <dbReference type="EnsemblBacteria" id="ABB30755">
        <property type="protein sequence ID" value="ABB30755"/>
        <property type="gene ID" value="Gmet_0512"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0512"/>
    <dbReference type="eggNOG" id="COG0725">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065520_3_1_7"/>
    <dbReference type="OMA" id="VCAPQVP"/>
    <dbReference type="OrthoDB" id="1506401at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015689">
        <property type="term" value="P:molybdate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005950">
        <property type="entry name" value="ModA"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004846">
        <property type="entry name" value="ModA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01256">
        <property type="entry name" value="modA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223307" evidence="4">
        <location>
            <begin position="26"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>molybdate</name>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004846-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="251" mass="27103" checksum="EEABA9C29DB6B5A5" modified="2005-11-22" version="1">MKNMIMNAITLAFCCILFAAPAALAGELNLSAAASLKDAINELSAVFVQKHPEVKIARNYGGSGVLAKQIEQGAPADLFISANPEWLDYLRERKLVESATIGTFAYNTLVFAGAAKQQAAGMNDLPKLRKIAVGSPRSVPAGEYALEAMRKAGIEKELAGKLVMAKDVREAMKYAELGEVDGAFVYRTDALLLGKQAKILFVVPEGLHGRVTYPLALTVAGAKKKEARGFLRFLRSVEAKRILVRYGFAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YC8</accession>
    <name>Q39YC8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_0503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>diphosphate + H2O = H(+) + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512199.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0503"/>
    <dbReference type="EnsemblBacteria" id="ABB30746">
        <property type="protein sequence ID" value="ABB30746"/>
        <property type="gene ID" value="Gmet_0503"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0503"/>
    <dbReference type="eggNOG" id="COG1227">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025243_1_0_7"/>
    <dbReference type="OMA" id="TIIANMF"/>
    <dbReference type="OrthoDB" id="732679at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010766">
        <property type="entry name" value="DRTGG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07085">
        <property type="entry name" value="DRTGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="SSF64182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="74"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="548" mass="59609" checksum="0B1F21EAF9A83CAC" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YG1</accession>
    <name>Q39YG1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cobyrinate a,c-diamide synthase</fullName>
            <ecNumber evidence="4">6.3.5.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cobyrinic acid a,c-diamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4 7" type="primary">cbiA</name>
        <name evidence="7" type="ordered locus">Gmet_0470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>2 ATP + cob(II)yrinate + 2 H2O + 2 L-glutamine = 2 ADP + cob(II)yrinate a,c diamide + 2 H(+) + 2 L-glutamate + 2 phosphate</text>
            <dbReference type="Rhea" id="RHEA:26289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58537"/>
            <dbReference type="ChEBI" id="CHEBI:58894"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 10/10.</text>
    </comment>
    <comment type="domain">
        <text evidence="4">Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="4">The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CobB/CbiA family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CobB/CobQ family. CobQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.11" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513839.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0470"/>
    <dbReference type="EnsemblBacteria" id="ABB30713">
        <property type="protein sequence ID" value="ABB30713"/>
        <property type="gene ID" value="Gmet_0470"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0470"/>
    <dbReference type="eggNOG" id="COG1797">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022752_2_0_7"/>
    <dbReference type="OMA" id="QPFKCGP"/>
    <dbReference type="OrthoDB" id="692368at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00231"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042242">
        <property type="term" value="F:cobyrinic acid a,c-diamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00027">
        <property type="entry name" value="CobB_CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004484">
        <property type="entry name" value="CbiA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002586">
        <property type="entry name" value="CobQ/CobB/MinD/ParA_Nub-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011698">
        <property type="entry name" value="GATase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43873">
        <property type="entry name" value="PTHR43873"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01656">
        <property type="entry name" value="CbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07685">
        <property type="entry name" value="GATase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00379">
        <property type="entry name" value="cobB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="3 4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CbiA" evidence="5">
        <location>
            <begin position="4"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="GATase_3" evidence="6">
        <location>
            <begin position="247"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="site" description="Increases nucleophilicity of active site Cys" evidence="4">
        <location>
            <position position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="462" mass="50224" checksum="FE6EC02994020997" modified="2005-11-22" version="1">MKSIIIAAPHSGSGKTTITLGIMECLKRRGLTVAPFKVGPDFIDPGYHRLICGRPSVNLDGWMCGGDFVQETFFHHAAGADIAVVEGVMGLFDGIGGVSDEGSTAEVAKLLGGPVVLVADAKGQARSVAALVKGFADFDPEVRVVGVIFNNVASDAHGRILREAVESHLPDVRVLGCIPRDESLSIPSRHLGLFTVDENPLPAEFLDHLVEVVREHVDLGMLWSVATLQGASDVKRRQDAPRREPVRIGVARDAAFCFVYEDNLRLLREAGAELVEFSPLADRELPEGVAGLYLPGGYPEVFADVLADNTPMKDAVRGAVVGEMPVYAECGGFIYLSRGVTGMRDDLESFNEFVGIFPVATLMLPRRKALGYREVELAADSIIGPVGAMARGHEFHYSEMEAMPPEVERLYRVRRAGIDLGTEGYRHRNCLASYVHIHFGSCPDMAEAFVNHCRNYAQRSHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YG5</accession>
    <name>Q39YG5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Bifunctional adenosylcobalamin biosynthesis protein</fullName>
            <ecNumber evidence="12">2.7.1.156</ecNumber>
            <ecNumber evidence="12">2.7.7.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">cobU</name>
        <name evidence="15" type="ordered locus">Gmet_0466</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 12">Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>adenosylcob(III)inamide + ATP = adenosylcob(III)inamide phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15769"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>adenosylcob(III)inamide + GTP = adenosylcob(III)inamide phosphate + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15765"/>
            <dbReference type="ChEBI" id="CHEBI:2480"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="EC" id="2.7.1.156"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 12">
            <text>adenosylcob(III)inamide phosphate + GTP + H(+) = adenosylcob(III)inamide-GDP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22712"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58502"/>
            <dbReference type="ChEBI" id="CHEBI:60487"/>
            <dbReference type="EC" id="2.7.7.62"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">Cofactor biosynthesis; adenosylcobalamin biosynthesis; adenosylcobalamin from cob(II)yrinate a,c-diamide: step 6/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 12">Belongs to the CobU/CobP family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.156" evidence="12"/>
    <dbReference type="EC" id="2.7.7.62" evidence="12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513835.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0466"/>
    <dbReference type="EnsemblBacteria" id="ABB30709">
        <property type="protein sequence ID" value="ABB30709"/>
        <property type="gene ID" value="Gmet_0466"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0466"/>
    <dbReference type="eggNOG" id="COG2087">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094161_0_1_7"/>
    <dbReference type="OMA" id="DCLTVWL"/>
    <dbReference type="OrthoDB" id="1903913at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00236"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036429">
        <property type="term" value="F:adenosylcobinamide kinase (ATP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036428">
        <property type="term" value="F:adenosylcobinamide kinase (GTP-specific) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008820">
        <property type="term" value="F:cobinamide phosphate guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00544">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003203">
        <property type="entry name" value="Cobinamide_kinase/P_G-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34848">
        <property type="entry name" value="PTHR34848"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02283">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006135">
        <property type="entry name" value="CobU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12 15" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="GMP-histidine intermediate" evidence="13">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="34"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="51"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00003889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00007490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR006135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR006135-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB30709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="172" mass="18512" checksum="58246586EC953537" modified="2005-11-22" version="1">MAPVIFITGGGRSGKSRLAERISGGFGAPLGYLATGTAGDGEMAERIARHRQRRGDDWTTIEEPLDLAGVLRENDGRFSAILVDCVTLWLTNLLLACDDPARCVARVKELTSLFPQLTTPLVLVSNEVGMGIVPENRLARQFRDLAGEANEMIAAAAGEVYVTFSGLPLRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YI1</accession>
    <name>Q39YI1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0450"/>
    <dbReference type="EnsemblBacteria" id="ABB30693">
        <property type="protein sequence ID" value="ABB30693"/>
        <property type="gene ID" value="Gmet_0450"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0450"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_1_7"/>
    <dbReference type="OMA" id="MSWEITP"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="274" mass="29461" checksum="37BF31CFA512DBB2" modified="2005-11-22" version="1">MNIVVLGASGVLGRAFAQAATAVGAACIVAGRKDPEIGLPHLPVDVTDPSSVSNFFTALGKRNLRIDVAFNFTGTHHAVMKLGQEDIPELLNDWSRVINTNLTGAFLLTAGFARLFVKQRHGHLVHLCSDASRVSLEGSHAYVASKHGLEGLVKSSAAQLARFGVRVNGLAPGTVETPLNRHLLRDDVGQLSRRAASILAHTPTKRFATVEGVVESAIALCIPQRHLTGNVIFCDDGYVIEGHSWPDGTWAAYQSPETLTDLLHFYDDPESNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YI4</accession>
    <name>Q39YI4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MAF_flag10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0447</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513815.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0447"/>
    <dbReference type="EnsemblBacteria" id="ABB30690">
        <property type="protein sequence ID" value="ABB30690"/>
        <property type="gene ID" value="Gmet_0447"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0447"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_340603_0_0_7"/>
    <dbReference type="OMA" id="VGPTVTN"/>
    <dbReference type="OrthoDB" id="724933at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002826">
        <property type="entry name" value="MptE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01973">
        <property type="entry name" value="MAF_flag10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="MAF_flag10" evidence="2">
        <location>
            <begin position="175"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="756"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="839" mass="94382" checksum="4DF6DE455A5896E1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YV6</accession>
    <name>Q39YV6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cbcS-2</name>
        <name evidence="9" type="ordered locus">Gmet_0325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512297.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0325"/>
    <dbReference type="EnsemblBacteria" id="ABB30568">
        <property type="protein sequence ID" value="ABB30568"/>
        <property type="gene ID" value="Gmet_0325"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0325"/>
    <dbReference type="eggNOG" id="ENOG503384B">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_143263_0_0_7"/>
    <dbReference type="OMA" id="IISCENC"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012286">
        <property type="entry name" value="Tetrahaem_cytochrome"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14537">
        <property type="entry name" value="Cytochrom_c3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_c3_2" evidence="8">
        <location>
            <begin position="83"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="181" mass="20064" checksum="9EDECC2782E0BBD6" modified="2005-11-22" version="1">MGNHVWRPLYIAVALIALVLVARTFLVPKDFGVHERGYMYGWHRKGNEAEWKAVTVKYRTAAYCKECHADKAESLARTPHGIISCENCHGPALNHPEDPPTLTIDRSRKLCLRCHAALITPTSGRASIAGINPETHNPEAECVLCHDPHNPVTREAHAKRDEEAGMLGASERGSEAYPLVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YW4</accession>
    <name>Q39YW4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Toxin, RelE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514027.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0316"/>
    <dbReference type="EnsemblBacteria" id="ABB30560">
        <property type="protein sequence ID" value="ABB30560"/>
        <property type="gene ID" value="Gmet_0316"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0316"/>
    <dbReference type="eggNOG" id="COG4737">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_110687_1_2_7"/>
    <dbReference type="OMA" id="MAYPKST"/>
    <dbReference type="OrthoDB" id="2029118at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009387">
        <property type="entry name" value="HigB-2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06296">
        <property type="entry name" value="RelE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039032">
        <property type="entry name" value="HigB-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="112" mass="12697" checksum="9B415994C1374D60" modified="2005-11-22" version="1">MPYIDYMVTFVESPLFTKQVHDYLTDDEYRIFQAFLAATLDAGDVVRGSGGVRKVRWNRRGTGKSGGVRVLYFARSEAGEIWLLLIYAKSAVDSIPGHILKALKEEMEHVTR</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-09-02" modified="2022-05-25" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z26</accession>
    <name>COXX_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protoheme IX farnesyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.141</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heme B farnesyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Heme O synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ctaB</name>
        <name type="ordered locus">Gmet_0253</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2E,6E)-farnesyl diphosphate + H2O + heme b = diphosphate + Fe(II)-heme o</text>
            <dbReference type="Rhea" id="RHEA:28070"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
            <dbReference type="EC" id="2.5.1.141"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Porphyrin-containing compound metabolism; heme O biosynthesis; heme O from protoheme: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.141" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513569.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z26"/>
    <dbReference type="SMR" id="Q39Z26"/>
    <dbReference type="STRING" id="269799.Gmet_0253"/>
    <dbReference type="EnsemblBacteria" id="ABB30498">
        <property type="protein sequence ID" value="ABB30498"/>
        <property type="gene ID" value="Gmet_0253"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0253"/>
    <dbReference type="eggNOG" id="COG0109">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_029631_3_1_7"/>
    <dbReference type="OMA" id="PPLMGYC"/>
    <dbReference type="OrthoDB" id="1875497at2"/>
    <dbReference type="UniPathway" id="UPA00834">
        <property type="reaction ID" value="UER00712"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008495">
        <property type="term" value="F:protoheme IX farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048034">
        <property type="term" value="P:heme O biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13957">
        <property type="entry name" value="PT_UbiA_Cox10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00154">
        <property type="entry name" value="CyoE_CtaB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006369">
        <property type="entry name" value="Protohaem_IX_farnesylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43448">
        <property type="entry name" value="PTHR43448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0350">Heme biosynthesis</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000346047" description="Protoheme IX farnesyltransferase">
        <location>
            <begin position="1"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="79"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="249"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00154"/>
        </source>
    </evidence>
    <sequence length="271" mass="28248" checksum="5B639C25E7BB9265" modified="2005-11-22" version="1">MIAEASRLLRPRLALLNGIAAVAGCLLAPEGAAMSLIVASLAGVTLLAAGGSALNQVMERDLDLLMERTRQRPLPTGELSPRAATAIGGISIIAGLVVLAGTGGIFPPLIGVGALAWYLGIYTPLKRRTSCSLLAGAVSGAVPPLVGWTITGGSLVDFRIVLVAGLLYLWQIPHFWLLQCRHAEDYRRAGLPLFAPGVTAGSPVFRVWIGAFAAGTLLLPLFGIIGGSAAPGFCAFPLLLVLLAFSRAEGALFSSLNLFPLLMVLALYLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZA9</accession>
    <name>Q39ZA9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH dehydrogenase I, L subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">nuoL-2</name>
        <name evidence="9" type="ordered locus">Gmet_0168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512755.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0168"/>
    <dbReference type="EnsemblBacteria" id="ABB30415">
        <property type="protein sequence ID" value="ABB30415"/>
        <property type="gene ID" value="Gmet_0168"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0168"/>
    <dbReference type="eggNOG" id="COG1009">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007100_6_0_7"/>
    <dbReference type="OMA" id="MGICSYF"/>
    <dbReference type="OrthoDB" id="1274678at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018393">
        <property type="entry name" value="NADHpl_OxRdtase_5_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001750">
        <property type="entry name" value="ND/Mrp_mem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003945">
        <property type="entry name" value="NU5C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001516">
        <property type="entry name" value="Proton_antipo_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42829">
        <property type="entry name" value="PTHR42829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00361">
        <property type="entry name" value="Proton_antipo_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00662">
        <property type="entry name" value="Proton_antipo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01974">
        <property type="entry name" value="NDH_I_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_N" evidence="8">
        <location>
            <begin position="64"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Proton_antipo_M" evidence="7">
        <location>
            <begin position="130"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="625" mass="66981" checksum="C732F7E1C75C77E5" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZE1</accession>
    <name>Q39ZE1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Magnesium transport protein CorA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">corA-2</name>
        <name evidence="7" type="synonym">corA</name>
        <name evidence="8" type="ordered locus">Gmet_0134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mediates influx of magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512719.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0134"/>
    <dbReference type="EnsemblBacteria" id="ABB30383">
        <property type="protein sequence ID" value="ABB30383"/>
        <property type="gene ID" value="Gmet_0134"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0134"/>
    <dbReference type="eggNOG" id="COG0598">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007127_5_0_7"/>
    <dbReference type="OMA" id="RAVSFMM"/>
    <dbReference type="OrthoDB" id="822653at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004488">
        <property type="entry name" value="Mg/Co-transport_prot_CorA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="SSF143865"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="SSF144083"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00383">
        <property type="entry name" value="corA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="317" mass="36721" checksum="B1259316E13100B9" modified="2005-11-22" version="1">MIKAYLRAEDSFRTVSVEPDELVDLDVSSLIWLDLLSPSTDELATVERSLKIELPTRQESEEIEFSSRFWEDESGIDINTYFLVRQEEKFHNETVSFILRGKFVVTIRFSDHRIFTEFSRKLRLSPRSFRDGADILSGILAMRVDMDADTLEALSRGIASLGRRGPQTFENPTEYLSHITDYEDINITIRENLTDKHRVLSSLLKSASISENLKKEFSMMMKDVNSLVISANFNFERLDYIQNLFLNHLSVEQNKVIKIFTVMSVIFLPPTMIASIYGMNYKHMPELEWVFGYPFALTLIILSAVLPLYVFKKKGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZG5</accession>
    <name>Q39ZG5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514115.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0110"/>
    <dbReference type="EnsemblBacteria" id="ABB30359">
        <property type="protein sequence ID" value="ABB30359"/>
        <property type="gene ID" value="Gmet_0110"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0110"/>
    <dbReference type="eggNOG" id="ENOG502ZCF6">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089932_0_0_7"/>
    <dbReference type="OMA" id="AGYAYPV"/>
    <dbReference type="OrthoDB" id="1866984at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223485" evidence="1">
        <location>
            <begin position="23"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="242" mass="25080" checksum="EB10CE594AF5159E" modified="2005-11-22" version="1">MNKALSISALALALSLPLGAHAFGPGASSMGGATAPAGVPLAGKVAETMASGGYTYLLLERDGKKTWAAIPETPVEVGREITLKPGMEMKNFASKALKRTFESIYFSEGLASAVESTAGKSSPGSKGVVVAPAEQVKVEKAASPNAHTIAETYEQRGSLDGKPVAVRGKVMRVSAGIMGKNWVHLQDGSGDAKKGTNDLTVTTQDLPAVGDVVTATGTLRKDKDFGGGYRYQVIIEEGTVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZP7</accession>
    <name>Q39ZP7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513793.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0027"/>
    <dbReference type="EnsemblBacteria" id="ABB30277">
        <property type="protein sequence ID" value="ABB30277"/>
        <property type="gene ID" value="Gmet_0027"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0027"/>
    <dbReference type="HOGENOM" id="CLU_122780_0_0_7"/>
    <dbReference type="OMA" id="GCCSTEL"/>
    <dbReference type="OrthoDB" id="1631180at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223473" evidence="1">
        <location>
            <begin position="27"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="195" mass="21585" checksum="5807B9608C285EB5" modified="2005-11-22" version="1">MVSFCCRLTRALVFTALLAIVFMVLAGCGPKTQISVSPSFRPASDVETAYVVPFGGALVPEEFSATVFNDFVDQLNGRRRETGIRSFAILKDEVSAVDPGWLARQYYISGDIWSYVEDSGCCSTNIRVKARVYVHEPGRSIPSVEIFVPMESFFDHDRSTIDRERGRLARDLARDLSQKVLAAMAPLRPPVSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="26" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEP6</accession>
    <name>J9JEP6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3640"/>
    <dbReference type="EnsemblBacteria" id="AFR42856">
        <property type="protein sequence ID" value="AFR42856"/>
        <property type="gene ID" value="Gmet_3640"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3640"/>
    <dbReference type="HOGENOM" id="CLU_1935029_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="130" mass="13800" checksum="43311A811EB6A16D" modified="2012-10-31" version="1">MKGQHATMKFSHVPIQAVAMVMVVLHLFLFPLVHAHGLAFVEPGGPHASDIVCLATDADAGHDSTEDAGHDSTGDHHGSSGICHPDTPFVVTHSQSHAVTQLIVELSPSYAGRLLLGYPRPLYIPPRNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="51" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PP2</accession>
    <name>Q39PP2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_A3577</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514715.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3577"/>
    <dbReference type="EnsemblBacteria" id="ABB33782">
        <property type="protein sequence ID" value="ABB33782"/>
        <property type="gene ID" value="Gmet_A3577"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3577"/>
    <dbReference type="HOGENOM" id="CLU_1308644_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="210" mass="24397" checksum="498438B6BE7C3763" modified="2005-11-22" version="1">MKKESPKHELKSLKDLLDFVRDYPEFMDEITTAMPKATALPGSNQSDFIQPIMPHIVRLKIWGMSDNSIRQLIDFEGPFYFDPRGFGKVLHTAIKKYARSVRYEIAEEVGKIIRESGGDDGHLTETYMDEAIHLFDKWRFPEDQGYENVTDYEFGEAILWAMRGFDPSLYFRRVTAQVLGRKMVKRLKLLYEIDFDSNETHPAEPAHKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PP7</accession>
    <name>Q39PP7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conjugal transfer entry/exclusion protein TrbJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_A3572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="5">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="5">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="5">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514721.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3572"/>
    <dbReference type="EnsemblBacteria" id="ABB33777">
        <property type="protein sequence ID" value="ABB33777"/>
        <property type="gene ID" value="Gmet_A3572"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3572"/>
    <dbReference type="eggNOG" id="COG5314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1159763_0_0_7"/>
    <dbReference type="OMA" id="QKMEPRW"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014147">
        <property type="entry name" value="T4SS_TrbJ"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02780">
        <property type="entry name" value="TrbJ_Ti"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0614">Plasmid</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004222965" evidence="3">
        <location>
            <begin position="21"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="206"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="239" mass="26124" checksum="F2F944A1EE334F8A" modified="2005-11-22" version="1">MKKALIVTVLILSMSAQAHATIPVLDYTNWAQNLFSYVQQVATAINTAEQLATQYQQLEVAIRQARQLNSDQIRGRIMNGIRQLAEIQQKTRGITYDYGRTEGAFDQYYPDMAAYNGMSGKDYAAQAAKANQQLQNSVRDAMLAQGLISNAATDQDALNALVAASNSADGQLAAAQAGNQISAMVAQQLIQLQQIMATSAREQSSYMAAQAAEKAKPLKKGDLPKGDDRNMLDYLRKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PS4</accession>
    <name>Q39PS4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">yrdA</name>
        <name evidence="1" type="ordered locus">Gmet_3545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513701.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3545"/>
    <dbReference type="EnsemblBacteria" id="ABB33750">
        <property type="protein sequence ID" value="ABB33750"/>
        <property type="gene ID" value="Gmet_3545"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3545"/>
    <dbReference type="eggNOG" id="COG0663">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064827_7_1_7"/>
    <dbReference type="OMA" id="YVTIGHN"/>
    <dbReference type="OrthoDB" id="1242595at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="SSF51161"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="177" mass="19159" checksum="0D91B9D7795C3539" modified="2005-11-22" version="1">MIRSFQGMNPRIDSSAFIAETAVVIGDVTVGAESSIWYNVVVRGDVNFIRIGARSNIQDLTMLHVTHKKHADDPGAPLVIGDDVTVGHSVTLHGCTIENGAFIGMQAMVMDKAVVGEGALVGARALVTEGTVIPPHTLWVGAPARYKRDLTPDEIAWLKRSAGNYVRYSREYLDDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PX7</accession>
    <name>Q39PX7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">frx-5</name>
        <name evidence="7" type="ordered locus">Gmet_3492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513649.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3492"/>
    <dbReference type="EnsemblBacteria" id="ABB33697">
        <property type="protein sequence ID" value="ABB33697"/>
        <property type="gene ID" value="Gmet_3492"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3492"/>
    <dbReference type="eggNOG" id="COG1141">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_6_4_7"/>
    <dbReference type="OMA" id="VSCIHWR"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001080">
        <property type="entry name" value="3Fe4S_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00352">
        <property type="entry name" value="3FE4SFRDOXIN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="73" mass="7922" checksum="E07BD51DC7E04C2A" modified="2005-11-22" version="1">MTKAPLVDKDVCISCGLCVDNIPDVFRFDDDNKAECFDPNGAAEDVIQSDAIDACPVSCISWSTDPDYLKSFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q49</accession>
    <name>Q39Q49_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome partitioning ATPase Soj</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514220.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3413"/>
    <dbReference type="EnsemblBacteria" id="ABB33625">
        <property type="protein sequence ID" value="ABB33625"/>
        <property type="gene ID" value="Gmet_3413"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3413"/>
    <dbReference type="eggNOG" id="COG1192">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037612_1_4_7"/>
    <dbReference type="OMA" id="VQCEYFA"/>
    <dbReference type="OrthoDB" id="729012at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025669">
        <property type="entry name" value="AAA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13614">
        <property type="entry name" value="AAA_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA_31" evidence="1">
        <location>
            <begin position="3"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="257" mass="27734" checksum="0CE8E05536F9466B" modified="2005-11-22" version="1">MAKKICIANQKGGVGKTTTAVNLAASLAAAEKRTLLVDMDPQGNAGSGVGIDKGSLTESVYDAIINDADPATLIVRTDLACLDLLPATTDLAGAELELVSAMAREWKLKEALAHLDDRYDYIIIDCPPSLGLLTVNAMTAADSVLIPLQCEYYAMEGLSQIIKTIKLVQKGLNPKLAIEGILLTMYDGRINLSRQVSEEIRTHFGSLAFQTVVPRNVRLSEAPSHGRPIILYDITSKGAVTYMELAKELMEREAHHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q65</accession>
    <name>Q39Q65_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3397</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3397"/>
    <dbReference type="EnsemblBacteria" id="ABB33609">
        <property type="protein sequence ID" value="ABB33609"/>
        <property type="gene ID" value="Gmet_3397"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3397"/>
    <dbReference type="HOGENOM" id="CLU_2699438_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="73" mass="7530" checksum="D97CD2052A8FF360" modified="2005-11-22" version="1">MARGAGEKTPWLKTLPEQVQAVRAALAAAGGPATADTIARTLQRARTDKVAELLATLAAIGQAREVEPGTYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="111" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q97</accession>
    <name>Q39Q97_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Type II secretion system protein E</fullName>
            <shortName evidence="3">T2SS protein E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Type II traffic warden ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gspE</name>
        <name evidence="5" type="ordered locus">Gmet_3365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">ATPase component of the type II secretion system required for the energy-dependent secretion of extracellular factors such as proteases and toxins from the periplasm. Acts as a molecular motor to provide the energy that is required for assembly of the pseudopilus and the extrusion of substrates generated in the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GSP E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512591.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3365"/>
    <dbReference type="EnsemblBacteria" id="ABB33577">
        <property type="protein sequence ID" value="ABB33577"/>
        <property type="gene ID" value="Gmet_3365"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3365"/>
    <dbReference type="eggNOG" id="COG2804">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013446_10_6_7"/>
    <dbReference type="OMA" id="RSRIDGM"/>
    <dbReference type="OrthoDB" id="749544at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001482">
        <property type="entry name" value="T2SS/T4SS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013369">
        <property type="entry name" value="T2SS_GspE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007831">
        <property type="entry name" value="T2SS_GspE_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00437">
        <property type="entry name" value="T2SSE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05157">
        <property type="entry name" value="T2SSE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02533">
        <property type="entry name" value="type_II_gspE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00662">
        <property type="entry name" value="T2SP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="T2SP_E" evidence="4">
        <location>
            <begin position="338"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="520" mass="57003" checksum="CD0128D2ED72D116" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QF6</accession>
    <name>Q39QF6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3305</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512529.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3305"/>
    <dbReference type="DNASU" id="3739396"/>
    <dbReference type="EnsemblBacteria" id="ABB33518">
        <property type="protein sequence ID" value="ABB33518"/>
        <property type="gene ID" value="Gmet_3305"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3305"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729117_0_0_7"/>
    <dbReference type="OMA" id="IMIGCEQ"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017613">
        <property type="entry name" value="Dearomat_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03200">
        <property type="entry name" value="dearomat_oah"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="374" mass="41613" checksum="0D2A628205F82A92" modified="2005-11-22" version="1">MARTNVMIAETFPEYLVDHNLIDCEVESLCNGMVRYEKRPARRRDGSVAEGLYNAWIIFNNPRQYNSYTTEMVKATILAFRRASVDREVNAVVFTGVGDKAFCTGGNTKEYAEYYAGNPQEYRQYMRLFNDMVSSILGCDRPVICRVNGMRIGGGQEIGMACDFSIAQDLAKFGQAGPKHGSAAIGGATDFLPIMIGCEQAMVSGTLCEPFSAHKAARLGIIADVVPALKVGGTFVANPTVVTDRFLDEYGRVVQGEFKTGADFKAGQARIKEGEVDLSLLDEKVEELCAKLLETFPECMTKSLEELRKPKLQAWNLNKENSRAWLALNMMNEARIGFRAFNEGTKETGREIDFVKLRRQLAEGTPWAEELIEI</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QJ2</accession>
    <name>CHEB5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-glutamate methylesterase/protein-glutamine glutaminase 5</fullName>
            <ecNumber evidence="1">3.1.1.61</ecNumber>
            <ecNumber evidence="1">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cheB5</name>
        <name type="ordered locus">Gmet_3269</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-L-glutamate 5-O-methyl ester + H2O = H(+) + L-glutamyl-[protein] + methanol</text>
            <dbReference type="Rhea" id="RHEA:23236"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="3.1.1.61"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">Contains a C-terminal catalytic domain, and an N-terminal region which modulates catalytic activity.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated by CheA. Phosphorylation of the N-terminal regulatory domain activates the methylesterase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CheB family.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.61" evidence="1"/>
    <dbReference type="EC" id="3.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512706.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QJ2"/>
    <dbReference type="SMR" id="Q39QJ2"/>
    <dbReference type="STRING" id="269799.Gmet_3269"/>
    <dbReference type="EnsemblBacteria" id="ABB33482">
        <property type="protein sequence ID" value="ABB33482"/>
        <property type="gene ID" value="Gmet_3269"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3269"/>
    <dbReference type="eggNOG" id="COG2201">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_51_0_7"/>
    <dbReference type="OMA" id="YGMPMAV"/>
    <dbReference type="OrthoDB" id="1655418at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000156">
        <property type="term" value="F:phosphorelay response regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008984">
        <property type="term" value="F:protein-glutamate methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018277">
        <property type="term" value="P:protein deamination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006482">
        <property type="term" value="P:protein demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16432">
        <property type="entry name" value="CheB_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00099">
        <property type="entry name" value="CheB_chemtxs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008248">
        <property type="entry name" value="CheB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035909">
        <property type="entry name" value="CheB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000673">
        <property type="entry name" value="Sig_transdc_resp-reg_Me-estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01339">
        <property type="entry name" value="CheB_methylest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000876">
        <property type="entry name" value="RR_chemtxs_CheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52738">
        <property type="entry name" value="SSF52738"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50122">
        <property type="entry name" value="CHEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000264280" description="Protein-glutamate methylesterase/protein-glutamine glutaminase 5">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="1">
        <location>
            <begin position="10"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="CheB-type methylesterase" evidence="1">
        <location>
            <begin position="161"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00099"/>
        </source>
    </evidence>
    <sequence length="357" mass="37875" checksum="DFEC6FC654EAB5ED" modified="2005-11-22" version="1">MLPNQERKLRVLVVDDSSFMRMVIRSVLEKDPAIEVIAVAMDGVEGVEKALALRPDLITMDIEMPRLDGISALKEIMAKAPTRVLMVSTLTCEGAKATFDALDAGAIDYIPKNVTDSIDAQKAFKEELLRKVKGSGISILGRPLVSPSPRLVVPPRPVIIPRPAGQRYQYVGIGASTGGPVAVQEVLGRIPGNFPHGIVVAIHMPKAFTGPYAERLNTKCSLQVKEAKAGDIVQPGVVLVTPGGMHTALVRQGSTVAIRTIATAEYPQYIYIPSVDHMLTTFADACNGSLLGVILTGMGADGFKGMKHLKTKGGGTIVQDEATSTIYGMPRACIEGGVADTVLPLTQIGTEITKIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QM3</accession>
    <name>Q39QM3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3238</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512677.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3238"/>
    <dbReference type="EnsemblBacteria" id="ABB33451">
        <property type="protein sequence ID" value="ABB33451"/>
        <property type="gene ID" value="Gmet_3238"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3238"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1592999_0_0_7"/>
    <dbReference type="OMA" id="EDEYMRV"/>
    <dbReference type="OrthoDB" id="1495333at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="165" mass="19150" checksum="3134550BB85C7D3F" modified="2005-11-22" version="1">MTREYSVQEALKLAIKGEKDSMDFYRKAALVTRNERAQKVFDLLANEEVGHLKAFFDHYKGGEFGSVADYMAQPPDTKNPTYVALMKAVNEETPEQQALELALREEKSCIDQYTVLARDLIDPLVRSIFEQVIKETEKHLAMIEEEYRHVMTMVHESDQDIYVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QP9</accession>
    <name>Q39QP9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-glutamate O-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.80</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cheR44H</name>
        <name evidence="7" type="ordered locus">Gmet_3212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>L-glutamyl-[protein] + S-adenosyl-L-methionine = [protein]-L-glutamate 5-O-methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:24452"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:10311"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:82795"/>
            <dbReference type="EC" id="2.1.1.80"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.1.1.80" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33425.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3212"/>
    <dbReference type="DNASU" id="3740967"/>
    <dbReference type="EnsemblBacteria" id="ABB33425">
        <property type="protein sequence ID" value="ABB33425"/>
        <property type="gene ID" value="Gmet_3212"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3212"/>
    <dbReference type="eggNOG" id="COG1352">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025854_1_1_7"/>
    <dbReference type="OMA" id="YETSHEA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.155.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022642">
        <property type="entry name" value="CheR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000780">
        <property type="entry name" value="CheR_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022641">
        <property type="entry name" value="CheR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036804">
        <property type="entry name" value="CheR_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01739">
        <property type="entry name" value="CheR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03705">
        <property type="entry name" value="CheR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00996">
        <property type="entry name" value="CHERMTFRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00138">
        <property type="entry name" value="MeTrc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50123">
        <property type="entry name" value="CHER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CheR-type methyltransferase" evidence="6">
        <location>
            <begin position="27"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33425.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="307" mass="35215" checksum="56F572C0884EF3FA" modified="2012-10-31" version="2">MLPTTDISRDNAGHEAMILPTWMATESDETSLDFPDHALERVRDILRLRRNFDISSYKDKYLKRRIAIRVRATRSVTADAYCDLVARNERELELLLKGLTIHVSQFFRNSSTFEALRGTVLPAIFDRLRREGRDSATFWSVGCASGEEPYSLAIILRDSFRESLKEFKVSLVATDIDGGILDAARAGIYSPERLAEVPAEVKDRYFRPMGERFVLDPTIREMVDFRRSDLFDPESSVESDLILCRNVLIYFERSEQARILRGFVSSLCTGGVLVLGKAETLVAEVRQRFTTLCPMERIYQKNRFSVY</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-11-28" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QQ5</accession>
    <name>Y3206_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UPF0234 protein Gmet_3206</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_3206</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0234 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512644.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QQ5"/>
    <dbReference type="SMR" id="Q39QQ5"/>
    <dbReference type="STRING" id="269799.Gmet_3206"/>
    <dbReference type="EnsemblBacteria" id="ABB33419">
        <property type="protein sequence ID" value="ABB33419"/>
        <property type="gene ID" value="Gmet_3206"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3206"/>
    <dbReference type="eggNOG" id="COG1666">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099839_1_0_7"/>
    <dbReference type="OMA" id="SDFDRQE"/>
    <dbReference type="OrthoDB" id="1612988at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd11740">
        <property type="entry name" value="YajQ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00632">
        <property type="entry name" value="UPF0234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007551">
        <property type="entry name" value="DUF520"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035571">
        <property type="entry name" value="UPF0234-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035570">
        <property type="entry name" value="UPF0234_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036183">
        <property type="entry name" value="YajQ-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30476">
        <property type="entry name" value="PTHR30476"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04461">
        <property type="entry name" value="DUF520"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89963">
        <property type="entry name" value="SSF89963"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000261939" description="UPF0234 protein Gmet_3206">
        <location>
            <begin position="1"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00632"/>
        </source>
    </evidence>
    <sequence length="161" mass="17996" checksum="3244DCA087981FC9" modified="2005-11-22" version="1">MPSFDIVSKVDMQEVDNAVNQAVKEIGQRYDFKGSKSEVTLEKDAIKILADDDFRLKAIVDILQSKFIKRGISPKALQYGKAETASGGMVRQIITVQQGISKEKGKEVVAVIKDTKLKVQGQIQDDQVRVTGKNRDDLQEAIRTLKGKDLGIELQFVNFRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R26</accession>
    <name>Q39R26_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3084</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514538.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3084"/>
    <dbReference type="EnsemblBacteria" id="ABB33298">
        <property type="protein sequence ID" value="ABB33298"/>
        <property type="gene ID" value="Gmet_3084"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3084"/>
    <dbReference type="eggNOG" id="COG1565">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024840_1_1_7"/>
    <dbReference type="OMA" id="AFPVHVI"/>
    <dbReference type="OrthoDB" id="1220759at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PTHR12049"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="385" mass="43044" checksum="B4A3502BF7F0110E" modified="2005-11-22" version="1">MDQPDDNRLRGIILNRIREQGRIPFADFMAMCLYEPGLGYYTSPGRKVGAEGDFYTSINVHSVFGRLIAREICRMWEEMGRPASFDIVEAGAGHGRLATDVIDAIQELNPTLYDGIRLTLIEAEPSLAAVQGELLAPHLPKVSWSTPADLAEGRLRFTGCLYSNELIDSFPPHLVEMGPEGLREVFVAAEGDQFSEILDLPSTPELEAYLSRLGITFAVGQRAEINLNAVRWLESVATALERGFVLTIDYGYLAPELYGPMRLNGTLLCYYRHTIEENPYIRIGLQDMTTHVDFTTLAARGEELGLRKVWYGEQYRFLVATGMMEELMALEAAATSEKEQIAIRLALKKLILPEGGMGDTFKVLVQAKGVENPRLLCMRDWGKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="108" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R67</accession>
    <name>Q39R67_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tyrosine recombinase XerC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10 14" type="primary">xerC</name>
        <name evidence="14" type="ordered locus">Gmet_3042</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the 'phage' integrase family. XerC subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513602.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3042"/>
    <dbReference type="EnsemblBacteria" id="ABB33257">
        <property type="protein sequence ID" value="ABB33257"/>
        <property type="gene ID" value="Gmet_3042"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3042"/>
    <dbReference type="eggNOG" id="COG4974">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027562_9_0_7"/>
    <dbReference type="OMA" id="HSFASHM"/>
    <dbReference type="OrthoDB" id="745068at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009037">
        <property type="term" value="F:tyrosine-based site-specific recombinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006313">
        <property type="term" value="P:transposition, DNA-mediated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.443.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01808">
        <property type="entry name" value="Recomb_XerC_XerD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044068">
        <property type="entry name" value="CB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013762">
        <property type="entry name" value="Integrase-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002104">
        <property type="entry name" value="Integrase_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010998">
        <property type="entry name" value="Integrase_recombinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004107">
        <property type="entry name" value="Integrase_SAM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011931">
        <property type="entry name" value="Recomb_XerC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023009">
        <property type="entry name" value="Tyrosine_recombinase_XerC/XerD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02899">
        <property type="entry name" value="Phage_int_SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00589">
        <property type="entry name" value="Phage_integrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="SSF56349"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02224">
        <property type="entry name" value="recomb_XerC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51900">
        <property type="entry name" value="CB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51898">
        <property type="entry name" value="TYR_RECOMBINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0229">DNA integration</keyword>
    <keyword evidence="8 10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7 10 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core-binding (CB)" evidence="13">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Tyr recombinase" evidence="12">
        <location>
            <begin position="107"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB33257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="294" mass="32760" checksum="9DE6338552DEE23C" modified="2005-11-22" version="1">MEQEIAAFIRHLETERNVSPHTLAAYRSDLAQFREFVRQETGAAAEPEGVSHLLIRRWLALLHRDHTKSSVGRKLAAVRAFFKHLIRTGRLVKNPAELVSTPKKEKKVPYHLSIDEATALVETPKEPDILSLRDRAILETLYSCGVRVSELTGLNIGGIDLDDGTARVLGKGGKERIVPVGSIARAALSHYLTARNHPPLDAPLFTNARGGRLTPRSVRRVVDKHILRIAAMRKISPHTLRHTFATHLLEGGADLRAIQELLGHASLSTTQKYTHVGIDRLMEVYDKAHPKARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RE9</accession>
    <name>Q39RE9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, type 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512893.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2958"/>
    <dbReference type="DNASU" id="3740813"/>
    <dbReference type="EnsemblBacteria" id="ABB33175">
        <property type="protein sequence ID" value="ABB33175"/>
        <property type="gene ID" value="Gmet_2958"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2958"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_056366_0_0_7"/>
    <dbReference type="OMA" id="DCMHYLG"/>
    <dbReference type="OrthoDB" id="1518440at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="72"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="278" mass="30094" checksum="333BEFD2D70FBE68" modified="2005-11-22" version="1">MSDVTDAQAIADHWGRGDVFGLIVAALNQMAKPLDGLTVEELAPVDHFHSRGFPATVEFADRLPINAGEQILDIGCGLGGPARYMAKRFQCRVSGIDITGPFVEAANRLTALLHMEQQVEIAQGNGQRLPYPDSCFDGAYTQDVTMNVAERAGFFAEAYRVLKPGAFFALSEHGLGPQGKPHYPVPWSDDGTGAYLTAPAETRAILERTGFEAITVEDTGAKCVAGYGKVIERAEKGALPPLGLHLFMGESMVEKMRNAARNIEEGRTHPIQLICRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RH8</accession>
    <name>Q39RH8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Menaquinol oxidoreductase complex Cbc5, cytochrome c subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">cbcA</name>
        <name evidence="4" type="ordered locus">Gmet_2928</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512864.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2928"/>
    <dbReference type="EnsemblBacteria" id="ABB33146">
        <property type="protein sequence ID" value="ABB33146"/>
        <property type="gene ID" value="Gmet_2928"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2928"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_771076_0_0_7"/>
    <dbReference type="OMA" id="RMLPCIT"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010177">
        <property type="entry name" value="Paired_CXXCH_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09699">
        <property type="entry name" value="Paired_CXXCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223191" evidence="2">
        <location>
            <begin position="24"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="3">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="350" mass="38210" checksum="B55F830C7B1C728C" modified="2005-11-22" version="1">MTTLRSATLVLSILLVFPMVALAAAATEDGCIGCHGDKNISGKSGSHLFIDPGQYKKTSHSIIGCTSCHESVTSNHPNDGIRPSRATCKECHSPVHQEYAASLHANNAACADCHNPHAVKPPAMTSARDMNAMCAKCHETAKMVNVHAKWLPQADLHIDALPCITCHTGSQNYVITMYIEKRLGTKEHSDFKVASFDELTQLVPGDKDVKALIDTNGDNFISLAELRSFNRNSKHDDMRLWGMMTPEKVTHSYQILDNRWDCTFCHASGPRAMQTSFVAFPEKGGTYTRVAVEKGAVLDVLYGTPDFYMMGSTRSTALSIVGGLIVLGGMGFAGVHGTLRFLTRKNRKEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RM8</accession>
    <name>Q39RM8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514609.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2878"/>
    <dbReference type="CAZy" id="GT4">
        <property type="family name" value="Glycosyltransferase Family 4"/>
    </dbReference>
    <dbReference type="DNASU" id="3740789"/>
    <dbReference type="EnsemblBacteria" id="ABB33096">
        <property type="protein sequence ID" value="ABB33096"/>
        <property type="gene ID" value="Gmet_2878"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2878"/>
    <dbReference type="eggNOG" id="COG0438">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009583_0_3_7"/>
    <dbReference type="OMA" id="YMGRATR"/>
    <dbReference type="OrthoDB" id="635734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_4-like_N" evidence="2">
        <location>
            <begin position="26"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycos_transf_1" evidence="1">
        <location>
            <begin position="204"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="380" mass="42424" checksum="64A45FC4E80E9D0C" modified="2005-11-22" version="1">MAAVAHVKIDAAGEKRVLYLVDKSGFGGVQTIAYTLMRHGVDERIGMDFFFLRNINDRFGMEDVREPNVFYSRATHRYSLRPFVEILRFIREKKVSILHLNGNKSIILGLVIKKLFQPTIKIIAHEHGGVFDYSRWYAAFLKSFRNSFDLFITISNYRKHFLVERCLVAPSAIRVIDNFVDPARLATASASACGHTDRCDSEGDKPFVIGYVGGLSRIKGCDVLIRALPPLRERLGNFRVMIAGDGPARAELEELVAALGLGDIVSFLGFVDPPGIAYAQFDMMVIPSRSEEGPICLYEAWMMGLPVVASNAPVLNERIRDGETGILFQSDEPCDLAEKIYSVCRNPDVAAHIRAGGSCEAARHTVERYRGDLRDVYLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RQ0</accession>
    <name>Q39RQ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2856</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514560.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2856"/>
    <dbReference type="EnsemblBacteria" id="ABB33074">
        <property type="protein sequence ID" value="ABB33074"/>
        <property type="gene ID" value="Gmet_2856"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2856"/>
    <dbReference type="eggNOG" id="ENOG502ZNMP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076708_0_0_7"/>
    <dbReference type="OMA" id="LYDSHYQ"/>
    <dbReference type="OrthoDB" id="1715292at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="261" mass="28524" checksum="F416A5464FDA11A8" modified="2005-11-22" version="1">MVVDNTKLQKLLTDPPMPVTSRDLRRDGNVFHVGGELPPRETLETLFDSYCLAPAELFHLSFGAPDTFSNGETLARLIKKNFNTHILGTMDFPVSPALLERAYAAGVDIIHIPFTAFERSDQESRLASLQCAQTVFPRWAVASSLVLGEAPLETLLAGIDNLLSHGIVPLLQFPAPASRCGIEEAAAAYAHLATAWRTSKATMAPLLPLIALATPLVPQTQGGTLRGFMNRLRDRRLLAVSDLRRALRVRQVEESFESAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RX2</accession>
    <name>Q39RX2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">BioD and DRTGG domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2784</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511678.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2784"/>
    <dbReference type="EnsemblBacteria" id="ABB33002">
        <property type="protein sequence ID" value="ABB33002"/>
        <property type="gene ID" value="Gmet_2784"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2784"/>
    <dbReference type="eggNOG" id="COG0857">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040984_1_0_7"/>
    <dbReference type="OMA" id="ANLYQMP"/>
    <dbReference type="OrthoDB" id="687829at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028979">
        <property type="entry name" value="Ser_kin/Pase_Hpr-like_N_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75138">
        <property type="entry name" value="SSF75138"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="377" mass="41705" checksum="9F8C721295E76B9D" modified="2005-11-22" version="1">MARKIFIAATGQNCGKTTTSLSLLHLARKKYGRVGFMKPLGPKPATLRGVPMDKDAALMAQVFGLTKDLRWMSPVVVYPDTSRKVIDGEISPDGLRERILEAHAELEKQCDFIIIEGSGHPGVGSVMKLSNARIARMLDAPVLMVTGGGVGNVVDAVSVDLALFEKEGAQVRAILANKLVPHKREQILDYLQRAFADEPFPVIGGFDYQPVLANPTLDRVSKLLDLPLHGNRRDRNRIIHNVQIGAASTQRVAELLRDSTLLIVTSSRDELLVTLANLYQMPEYRSKLVGLVIPGIIPVSTITQQILERSKIPFLRNYTHTTAELYHLITEDVSKITAEDTEKLALIRSLAETRLDFDRLDALFGPAPRDPDRPRTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="112" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RX7</accession>
    <name>Q39RX7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane-bound transcriptional regulator, ribonuclease BN-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2779</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511682.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2779"/>
    <dbReference type="EnsemblBacteria" id="ABB32997">
        <property type="protein sequence ID" value="ABB32997"/>
        <property type="gene ID" value="Gmet_2779"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2779"/>
    <dbReference type="eggNOG" id="COG1295">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1959">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032288_2_0_7"/>
    <dbReference type="OMA" id="MTMMTIE"/>
    <dbReference type="OrthoDB" id="1421045at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000944">
        <property type="entry name" value="Tscrpt_reg_Rrf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017039">
        <property type="entry name" value="Virul_fac_BrkB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30213">
        <property type="entry name" value="PTHR30213"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02082">
        <property type="entry name" value="Rrf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03631">
        <property type="entry name" value="Virul_fac_BrkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00765">
        <property type="entry name" value="yihY_not_rbn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51197">
        <property type="entry name" value="HTH_RRF2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="453" mass="49938" checksum="16CC942EDCF34BC1" modified="2005-11-22" version="1">MAQRETAVDRIIGFFTHALWEMEPDSFGPVKGRLLRCLQIGALVVKDFLDDQCLIRASALAFSTLLSIVPFFALAFAVLKGFGVQNTLEPFILDQVAAGSHEIVDKIVAYINNTKVGSLGAIGLAALFVTVVTLLGNVEEAFNAIWGVRETRSLYRKFSDYLSVLVSGPILLFAAVSTTTTIESQAFVQWIMGYTYLGDALLALFRLVPYLSIWIALVFLYMFIPNTKVRFRSALVGGIIAGTIWQGAQWGYIHFQVGVAKYNAIYGTLAVLPVFMVWLYASWVIVLLGGEVVYAHQHLRTFRREVRTPAISNAARERLALAVIYEISLAFHNDRPPWSITGLAEHLDVPERSVRELLECLEDEGVLAAGCGDDPLYLPARDLEHIRVGEVLSSLRNQGVGLPGQLGGEDHVVVDDLWEAIEAAVRSALGDLSFRDLAERVPLAGEPLSRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S35</accession>
    <name>Q39S35_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sensor diguanylate cyclase, GAF domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511739.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2721"/>
    <dbReference type="EnsemblBacteria" id="ABB32939">
        <property type="protein sequence ID" value="ABB32939"/>
        <property type="gene ID" value="Gmet_2721"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2721"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3706">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4936">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_399425_0_0_7"/>
    <dbReference type="OMA" id="SIMIERA"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018771">
        <property type="entry name" value="PocR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10114">
        <property type="entry name" value="PocR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GGDEF" evidence="2">
        <location>
            <begin position="533"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="686" mass="75289" checksum="83C295CCF83FBE7A" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S82</accession>
    <name>Q39S82_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-dependent hydrolase YcbL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">ycbL</name>
        <name evidence="2" type="ordered locus">Gmet_2674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511787.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2674"/>
    <dbReference type="EnsemblBacteria" id="ABB32892">
        <property type="protein sequence ID" value="ABB32892"/>
        <property type="gene ID" value="Gmet_2674"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2674"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030571_5_4_7"/>
    <dbReference type="OMA" id="GAWGTNC"/>
    <dbReference type="OrthoDB" id="1581636at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="12"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="209" mass="22271" checksum="BB27F2F3B4D88BA3" modified="2005-11-22" version="1">MIFEIVVVGPMGVNCFILGCEETKEGVVVDPGADAGRILDRVRALGLTIRTVINTHGHFDHIGGNKAVLEATGGRLMIHRDDVHFLSRAADVAANYGLSTANSPPPDELLEDGMTVTFGKCAMKVFHTPGHTPGGCCLYLEGEGKVITGDTLFAESVGRTDFPGSSHEALITSIRTKLLPLPDETQVFPGHGEASSIGREKLYNPYLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SB7</accession>
    <name>Q39SB7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Phosphoenolpyruvate carboxykinase [GTP]</fullName>
            <shortName evidence="9">PEP carboxykinase</shortName>
            <shortName evidence="9">PEPCK</shortName>
            <ecNumber evidence="9">4.1.1.32</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">GTP-dependent phosphoenolpyruvate carboxykinase</fullName>
            <shortName evidence="9">GTP-PEPCK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pckG</name>
        <name evidence="12" type="synonym">pckA</name>
        <name evidence="12" type="ordered locus">Gmet_2638</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + oxaloacetate = CO2 + GDP + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:10388"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="4.1.1.32"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="9">Binds 1 Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.32" evidence="9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511823.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2638"/>
    <dbReference type="EnsemblBacteria" id="ABB32857">
        <property type="protein sequence ID" value="ABB32857"/>
        <property type="gene ID" value="Gmet_2638"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2638"/>
    <dbReference type="eggNOG" id="COG1274">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028872_1_1_7"/>
    <dbReference type="OMA" id="GPTNNWV"/>
    <dbReference type="OrthoDB" id="267285at2"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004613">
        <property type="term" value="F:phosphoenolpyruvate carboxykinase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00819">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.449.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00452">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018091">
        <property type="entry name" value="PEP_carboxykin_GTP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013035">
        <property type="entry name" value="PEP_carboxykinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008209">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035077">
        <property type="entry name" value="PEP_carboxykinase_GTP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035078">
        <property type="entry name" value="PEP_carboxykinase_GTP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008210">
        <property type="entry name" value="PEP_carboxykinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11561">
        <property type="entry name" value="PTHR11561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00821">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17297">
        <property type="entry name" value="PEPCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001348">
        <property type="entry name" value="PEP_carboxykinase_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68923">
        <property type="entry name" value="SSF68923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00505">
        <property type="entry name" value="PEPCK_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 9" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="12" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 9" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PEPCK_N" evidence="11">
        <location>
            <begin position="13"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PEPCK_GTP" evidence="10">
        <location>
            <begin position="236"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="211"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="9">
        <location>
            <begin position="381"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="264"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="263"/>
            <end position="268"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="414"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="507"/>
            <end position="510"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="617" mass="69155" checksum="A9C3B97701F32E16" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SE1</accession>
    <name>Q39SE1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GAF domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511847.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2614"/>
    <dbReference type="EnsemblBacteria" id="ABB32833">
        <property type="protein sequence ID" value="ABB32833"/>
        <property type="gene ID" value="Gmet_2614"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2614"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1076542_0_0_7"/>
    <dbReference type="OMA" id="RHCSIML"/>
    <dbReference type="OrthoDB" id="1584599at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAF" evidence="1">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="263" mass="28814" checksum="66A009566779025D" modified="2005-11-22" version="1">MQTDGNFFVKLVGMSTFLEQQENLDESLNDFAAMAANIVNVENCSIMLFREGDKPGDFRLRVFAKTGHLPENAFREAVKVNDGIAGRVAATGQALLVEDITRSPYLPLARTPEGTSKCFISVPVLIGTKVVGVINLTNPRDGRCFTDDDLALTTFVALLVGKSIQVVQLQNVLRSRFAQMAISRETKSLVASKVTEFYQDPARLARIAAKTFYREMTRAGLGAEHILNAATEIVGLLGDNLKKHKKRLTDTQATAPQEQIIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SI6</accession>
    <name>Q39SI6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513465.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2569"/>
    <dbReference type="EnsemblBacteria" id="ABB32788">
        <property type="protein sequence ID" value="ABB32788"/>
        <property type="gene ID" value="Gmet_2569"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2569"/>
    <dbReference type="eggNOG" id="ENOG5033C3D">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_203783_0_0_7"/>
    <dbReference type="OMA" id="ECLWADD"/>
    <dbReference type="OrthoDB" id="2059197at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription, termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011112">
        <property type="entry name" value="Rho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07498">
        <property type="entry name" value="Rho_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho_N" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="59" mass="6634" checksum="2F2917FEEF6DD2B7" modified="2005-11-22" version="1">MKMQEIKEIAKQRGVKAGTLKKAELIKAIQRMEGNSDCYAEGKAANCGQDQCLWREDCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="107" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SJ8</accession>
    <name>Q39SJ8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GTPase HflX</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">GTP-binding protein HflX</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hflX</name>
        <name evidence="8" type="ordered locus">Gmet_2557</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer. Associates with the 50S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="5">May associate with membranes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32776.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2557"/>
    <dbReference type="EnsemblBacteria" id="ABB32776">
        <property type="protein sequence ID" value="ABB32776"/>
        <property type="gene ID" value="Gmet_2557"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2557"/>
    <dbReference type="eggNOG" id="COG2262">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019597_7_1_7"/>
    <dbReference type="OMA" id="TGRGVQM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01878">
        <property type="entry name" value="HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00900">
        <property type="entry name" value="GTPase_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030394">
        <property type="entry name" value="G_HFLX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032305">
        <property type="entry name" value="GTP-bd_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016496">
        <property type="entry name" value="GTPase_HflX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025121">
        <property type="entry name" value="GTPase_HflX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042108">
        <property type="entry name" value="GTPase_HflX_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10229">
        <property type="entry name" value="PTHR10229"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16360">
        <property type="entry name" value="GTP-bdg_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13167">
        <property type="entry name" value="GTP-bdg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03156">
        <property type="entry name" value="GTP_HflX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51705">
        <property type="entry name" value="G_HFLX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hflx-type G" evidence="7">
        <location>
            <begin position="380"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="339"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32776.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="556" mass="62989" checksum="66A638BB3B3D0426" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="47" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SL8</accession>
    <name>Q39SL8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32756">
        <property type="protein sequence ID" value="ABB32756"/>
        <property type="gene ID" value="Gmet_2535"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2535"/>
    <dbReference type="eggNOG" id="ENOG5033V07">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_508769_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="535" mass="62976" checksum="DC1B6B138A76D778" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SU5</accession>
    <name>Q39SU5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2454</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366055.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2454"/>
    <dbReference type="EnsemblBacteria" id="ABB32679">
        <property type="protein sequence ID" value="ABB32679"/>
        <property type="gene ID" value="Gmet_2454"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2454"/>
    <dbReference type="eggNOG" id="COG3852">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_39_7"/>
    <dbReference type="OMA" id="INEHNGF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="157"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="367" mass="40520" checksum="DF126C58C82F0B6B" modified="2005-11-22" version="1">MTLTGPLRILFLAAAIIGISLFHYLTPLHLPALHDIFQRLYYLPIILAALWFGLRGGLAASIIVSILYVPHVLFQWGVHPSLELEKFLEILLYNVVGGVTGFLCQKEGERREELERAARRLEESYRALRSQADLIIGIEEQLRRAERLSALGELSAMLAHEIRNPLGSIRGTAEILRDDFQPGHPKHEFLEILLKETDRLNRVVEDFLRLSRPGDGERKTCDLAAELRELVTLLGSDAAARGVRIGLEADEVPPVTGDPEKLRQAFLNLMLNGIQATGAGGTVTVRVKMFPRSGDDRPLVELAFADTGAGIPRESLERIFTPFFTTKEGGTGLGLAITQRIVEGHGGTVTVESEPGQGTTFRVRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SX3</accession>
    <name>Q39SX3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Gmet_2426</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512474.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2426"/>
    <dbReference type="EnsemblBacteria" id="ABB32651">
        <property type="protein sequence ID" value="ABB32651"/>
        <property type="gene ID" value="Gmet_2426"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2426"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2198">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG5002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_64_7"/>
    <dbReference type="OMA" id="YAEANSF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021796">
        <property type="entry name" value="DUF3365"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11845">
        <property type="entry name" value="DUF3365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="12">
        <location>
            <begin position="247"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="334"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="11">
        <location>
            <begin position="576"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="HPt" evidence="13">
        <location>
            <begin position="733"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="300"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="7">
        <location>
            <position position="625"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="6">
        <location>
            <position position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="827" mass="91046" checksum="28A1A995E99B96C7" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T36</accession>
    <name>Q39T36_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EVE domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513257.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2363"/>
    <dbReference type="EnsemblBacteria" id="ABB32588">
        <property type="protein sequence ID" value="ABB32588"/>
        <property type="gene ID" value="Gmet_2363"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2363"/>
    <dbReference type="eggNOG" id="COG2947">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041799_2_2_7"/>
    <dbReference type="OMA" id="LWDGIRN"/>
    <dbReference type="OrthoDB" id="1829674at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="SSF88697"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="1">
        <location>
            <begin position="6"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="158" mass="18293" checksum="B9769F82CB8C979B" modified="2005-11-22" version="1">MIRERRFWLFKSEPSCFSFDDLKARPNGTEHWDGVRNFQARNLLRDEIKPGDGVLFYHSNIPEPAIVGIAEVVSEGYPDWTALDPSAEHFDPRAGGDNPVWYMVDVRYVRPLKRPVTLNEMKIHSELSGMVLLKRSRLSVQPVTQHEWEYILRLGGID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TD3</accession>
    <name>Q39TD3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">etfA-8</name>
        <name evidence="4" type="ordered locus">Gmet_2265</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366021.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2265"/>
    <dbReference type="EnsemblBacteria" id="ABB32491">
        <property type="protein sequence ID" value="ABB32491"/>
        <property type="gene ID" value="Gmet_2265"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2265"/>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_0_1_7"/>
    <dbReference type="OMA" id="HMAGMKH"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000089">
        <property type="entry name" value="Electra_flavoP_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ETF" evidence="3">
        <location>
            <begin position="5"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="322" mass="33851" checksum="FBEBC16F073E8587" modified="2005-11-22" version="1">MAAQIFAYIKHKGGAVDDTALELISAARNIDASAEPIALVAGSGADLDQACSQTASTYKQVWKLGNSAFAYPNAEVLRKALLAVLPTDAIVLVPHDAFGMDLSPGLSIKLDATFVADVLALEVSGNDLRVVRQEYGGQVSSHSLCRMDKGAVINIRPGAFAPVEALASIGEVVDKSSYVAEVSTGREFVELIEAVAGDVDITKEDILVSIGRGIGDEEGIQIAEELAEAMGGVVSCSRPIVDAKWMDKSRQVGTSGQTVKPKVYLACGISGSFQHLGGIKGNPFVVAINKNPKAPIFQVADVGIVADLQEFLPELTERINEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TK2</accession>
    <name>Q39TK2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Enoyl-CoA hydratase/isomerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365951.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2195"/>
    <dbReference type="EnsemblBacteria" id="ABB32422">
        <property type="protein sequence ID" value="ABB32422"/>
        <property type="gene ID" value="Gmet_2195"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2195"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009834_7_6_7"/>
    <dbReference type="OMA" id="ESARFCT"/>
    <dbReference type="OrthoDB" id="1498685at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="257" mass="28643" checksum="2BD5EE0D3F64E28B" modified="2005-11-22" version="1">MTEKFETIIFEKRGAIAVITMNRPDKLNACNTVMYRELDCVLDKIESDREVQAVVITGSGDKAFSAGADLEELNFDNLRDSSEYIKVDARAFRRLENIPQPVIAAVNGAAIGYGCKVAIVSDIAIASETAKFSLPGATFGAVHVIMLGRAREVMGRKRLSQLLLTGEKIDAHEAERYGIVNKVVPQDQVMAEAMKIANRIAECPPLSVQVTRRMLHRGMDDDYRWEDLLSPGLLLMEDVKEGRRAFKEKRKPKFVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TL9</accession>
    <name>Q39TL9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2176</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2176"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32405">
        <property type="protein sequence ID" value="ABB32405"/>
        <property type="gene ID" value="Gmet_2176"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2176"/>
    <dbReference type="eggNOG" id="COG0463">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025996_2_0_7"/>
    <dbReference type="OMA" id="LVNFRRH"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="8"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="324" mass="36904" checksum="20B83A5DD3BA15A0" modified="2005-11-22" version="1">MSAMLKLSVAICTYNGERFLREQLDSIARQTRLPDELILCDDGSSDRTLQIIDNFASSAPFEVKSSRNVSNIGSTKNFERAIGLCDGDIIALSDQDDVWHRDKLEVIERAFLDAPLTGAVFTNGAVVGDDLSPLGYTLWDTFRFKKKQQSCFKKGRALEVLLNHDVVTGATMAFRSALRDIVVPIPVEWVHDAWIALLTSIYSKIDFIDKNLIDYRQHSNQQIGSVKKNFTDHKNVAQSITDYYAQISKYEMLLDHIRCLNQVPNDYAIGKLHDKIEHMEVRNSICTSPKIIKTVEATCELLNRRYHNYSNGYFSFCKDIFWGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TQ4</accession>
    <name>Q39TQ4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-dependent hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2141</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513064.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2141"/>
    <dbReference type="EnsemblBacteria" id="ABB32370">
        <property type="protein sequence ID" value="ABB32370"/>
        <property type="gene ID" value="Gmet_2141"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2141"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048478_0_1_7"/>
    <dbReference type="OMA" id="HSPEHAC"/>
    <dbReference type="OrthoDB" id="733552at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="38"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="354" mass="40034" checksum="BF5EFFFF263B896F" modified="2005-11-22" version="1">MMLSMTFPYSPPHSDGELVEIGPDVRWLRMPVTYAPDHVNIYLVRVAGGWLIVDTGLDSPEARRIWEEVFSGPLAGEKVVGVYCTHYHVDHLGLAGYLTERWRVPLFMTYEEYYTLLGWPDLPQEVPWQHVEFFQRAGFPQELLPQTLVMFDFAREISPMPLSFVRLQDRSHLPLDEEWQVIVGRGHSPEHALLLSKVRKILISGDQLLPSISTNVSVSVMNPEDDPLSHWLASLDRLATIPDDVLVLPGHGLPFRGARKRVAELRGHHRRRSQVIVDACAGSELSAYELVKVLYSFSLGDFDLQLALGECLSHVRYLACRGRLEARLDGEGINRYRSVRGVRAVNGGAGFCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TR4</accession>
    <name>Q39TR4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p-hydroxybenzaldehyde dehydrogenase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">pcmO</name>
        <name evidence="7" type="ordered locus">Gmet_2131</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513074.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2131"/>
    <dbReference type="EnsemblBacteria" id="ABB32360">
        <property type="protein sequence ID" value="ABB32360"/>
        <property type="gene ID" value="Gmet_2131"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2131"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_1_0_7"/>
    <dbReference type="OMA" id="PFGGEKH"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="12"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="480" mass="51754" checksum="282FC7E6D6AE2B37" modified="2005-11-22" version="1">MKEYRLFINGEWVPSSTGTMADDINPATGDVYAKVHQASRDDIEQAIASAYRARVDWGKTVPAQREAILIKAAAILEERIPEFAEVLIEEGGATFGKAMFESSFVVTLLRSAAGECRRIFGETIPSDAPGLFSMSVRRPLGVIAGISPFNFPFLLAMKKVALALAAGNTFVLKPASPTPVIGLKIAELFEAAGLPKGVLNVIPVKGSTLGNTLVEDPRIRMVTFTGSTDVGKQLAEVAGRHQKKITLEMGGKSPLIVLKDADIDYAVDAAVFGIFLHQGQVCMANSRLIVEADIYDRFCEKLTAKVKGLKMGDPHKPDTVIGPLIDAKQCAFIDSQVHDALADGARVLSGGRSEGAFYQPTIVADVTRKMRIFDEESFGPVVCVIKAANSEEALALANDSSFGLSAGLITNDLQKAFDLSLRLESGMVHINDSSIFDEPHVPFGGVKDSGVGREGGHYSMEEMTEVKWITVQMGKRQFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TW4</accession>
    <name>Q39TW4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Benzoyl-CoA reductase electron transfer protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">bamG</name>
        <name evidence="7" type="ordered locus">Gmet_2081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514584.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2081"/>
    <dbReference type="EnsemblBacteria" id="ABB32310">
        <property type="protein sequence ID" value="ABB32310"/>
        <property type="gene ID" value="Gmet_2081"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2081"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_7"/>
    <dbReference type="OMA" id="HYAQEIY"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="16516" checksum="54702980CA863B99" modified="2005-11-22" version="1">MDISRIDQIIDKHDGEASSLIQILLDIQSEHNWLPKEALKRVCERLQVPMSRITHIATFYKAFSLVPKGRHQVHVCMGTACHVRGAQRVLDTVQEVTGVKSGETDSDLKFSVETVNCLGCCALGPVMEVDGKHHGNIAPSQIASVLNNCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TX9</accession>
    <name>Q39TX9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">etfA-2</name>
        <name evidence="8" type="ordered locus">Gmet_2066</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514037.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q39TX9"/>
    <dbReference type="STRING" id="269799.Gmet_2066"/>
    <dbReference type="EnsemblBacteria" id="ABB32295">
        <property type="protein sequence ID" value="ABB32295"/>
        <property type="gene ID" value="Gmet_2066"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2066"/>
    <dbReference type="eggNOG" id="COG1143">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_1_1_7"/>
    <dbReference type="OMA" id="LCKKHRP"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="448" mass="48588" checksum="86587D190257CC79" modified="2005-11-22" version="1">MTETKKTIKKPRGKARVLDGKCIACGARCESSCPVDGIEMNAAGEPTVLGEKCIGCAKCVKVCAAGALEMFYTPEELELLKQWDQQHHTVEEEVDEGEKQLREMLARYRGVWVFIEQYDGEAAKVSWELLGTGAELAKSLGVELSAVIIGHKVEHLCDEAFGYGAHKAITLDAPVFANYRTKPYTDAICHLISKHRPEIILMGATGQGRDLAGAVATIVKTGLTADCTGLGIDDKRNLMQTRPAFGGNIMATIMCDRFRPQMSTVRPHVMPMPEFQVGRTGEVVREQYDLREEDVLVKVIEVLSDKGGKDIDIAGAEIIVSGGRGLMNKENFAMLQELADELGGVVGASRSAVDAGWMPHSRQVGQTGKTVRPKIYVACGISGAIQHLVGMQDSDVVIAINRDPEAPIFQVATYGIVGDLFQIVPSIIRKVRSLKGQRGGVIPDRVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U69</accession>
    <name>Q39U69_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511868.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1976"/>
    <dbReference type="EnsemblBacteria" id="ABB32205">
        <property type="protein sequence ID" value="ABB32205"/>
        <property type="gene ID" value="Gmet_1976"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1976"/>
    <dbReference type="HOGENOM" id="CLU_2787956_0_0_7"/>
    <dbReference type="OMA" id="RAYYLQE"/>
    <dbReference type="OrthoDB" id="2050383at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="68" mass="8278" checksum="E549B58848328E9B" modified="2005-11-22" version="1">MADARETLEMMREVARTRISMLRDGITFYDNERRSYYLRQYEEKLAQIEHLIRRISIRLVEPSTEETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U88</accession>
    <name>Q39U88_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">MEMO1 family protein Gmet_1957</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1957</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the MEMO1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511887.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1957"/>
    <dbReference type="DNASU" id="3740137"/>
    <dbReference type="EnsemblBacteria" id="ABB32186">
        <property type="protein sequence ID" value="ABB32186"/>
        <property type="gene ID" value="Gmet_1957"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1957"/>
    <dbReference type="eggNOG" id="COG1355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038085_2_0_7"/>
    <dbReference type="OMA" id="EQEAQYG"/>
    <dbReference type="OrthoDB" id="1070303at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd07361">
        <property type="entry name" value="MEMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00055">
        <property type="entry name" value="MEMO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002737">
        <property type="entry name" value="MEMO1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11060">
        <property type="entry name" value="PTHR11060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01875">
        <property type="entry name" value="Memo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="267" mass="28860" checksum="1E5D8002F7604CA2" modified="2005-11-22" version="1">MTRQPAVAGQFYTDEPKRLRGDLQRMIPAETMKQRVKGIVAPHAGYVYSGHVAGAVYGAIEIPSTVVILGPNHHGFGAAAALYPEGEWLTPLGSVPIDVRLSQLVQKHVPLVEPEMSAHRFEHSLEVQVPFLQYCRADVSIVPICLGFGDYERCRLLGEGIARAIREFGEDVLIVASSDMTHYESADAARAKDEQAIAEVLALNPEGLVQICRRKNITMCGVIPATVMLVTAKALGASKAELISYATSGDVTGDNRQVVAYAAMAVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UF2</accession>
    <name>Q39UF2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecBCD enzyme subunit RecB</fullName>
            <ecNumber evidence="8">3.1.11.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Exonuclease V subunit RecB</fullName>
            <shortName evidence="8">ExoV subunit RecB</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Helicase/nuclease RecBCD subunit RecB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8 12" type="primary">recB</name>
        <name evidence="12" type="ordered locus">Gmet_1893</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides.</text>
            <dbReference type="EC" id="3.1.11.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotrimer of RecB, RecC and RecD. All subunits contribute to DNA-binding. Interacts with RecA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The C-terminal domain has nuclease activity and interacts with RecD. It interacts with RecA, facilitating its loading onto ssDNA.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">The N-terminal DNA-binding domain is a ssDNA-dependent ATPase and has ATP-dependent 3'-5' helicase function. This domain interacts with RecC.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.11.5" evidence="8"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511951.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1893"/>
    <dbReference type="EnsemblBacteria" id="ABB32122">
        <property type="protein sequence ID" value="ABB32122"/>
        <property type="gene ID" value="Gmet_1893"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1893"/>
    <dbReference type="eggNOG" id="COG1074">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001114_6_1_7"/>
    <dbReference type="OMA" id="KQSIYRW"/>
    <dbReference type="OrthoDB" id="137860at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008854">
        <property type="term" value="F:exodeoxyribonuclease V activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01485">
        <property type="entry name" value="RecB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011604">
        <property type="entry name" value="PDDEXK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004586">
        <property type="entry name" value="RecB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="PTHR11070"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF23">
        <property type="entry name" value="PTHR11070:SF23"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="SSF52980"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00609">
        <property type="entry name" value="recB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="10">
        <location>
            <begin position="1"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="11">
        <location>
            <begin position="473"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="DNA-binding and helicase activity, interacts with RecC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Nuclease activity, interacts with RecD and RecA" evidence="8">
        <location>
            <begin position="904"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="active site" description="For nuclease activity" evidence="8">
        <location>
            <position position="1098"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="19"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="964"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1085"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1098"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1200" mass="134081" checksum="62B0303F74532506" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UG3</accession>
    <name>Q39UG3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CBS domain pair-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511962.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1882"/>
    <dbReference type="EnsemblBacteria" id="ABB32111">
        <property type="protein sequence ID" value="ABB32111"/>
        <property type="gene ID" value="Gmet_1882"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1882"/>
    <dbReference type="eggNOG" id="COG3448">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040681_9_0_7"/>
    <dbReference type="OMA" id="WDKQVHQ"/>
    <dbReference type="OrthoDB" id="2014094at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="SSF54631"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="8"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="2">
        <location>
            <begin position="98"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="149" mass="16730" checksum="C460024B326080BB" modified="2005-11-22" version="1">MLKVRDIMTTDVVSVKRETTIRELAEIFTKHRVGSVPVVDESGNLIGIVTESDLIEQDKSLHIPTVISLFDWVIYLESEKKFEKELQKMTGQTVGDLYTDTAEMVTPDTPVSEVADIMSSKKLHALPVVEGKRLVGMVSRIDLIRTMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UG6</accession>
    <name>Q39UG6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">(R)-citramalate synthase</fullName>
            <ecNumber evidence="4">2.3.1.182</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">cimA</name>
        <name evidence="11" type="ordered locus">Gmet_1879</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O + pyruvate = (3R)-citramalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19045"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30934"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.182"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-isoleucine biosynthesis; 2-oxobutanoate from pyruvate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-IPM synthase/homocitrate synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.182" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511965.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1879"/>
    <dbReference type="EnsemblBacteria" id="ABB32108">
        <property type="protein sequence ID" value="ABB32108"/>
        <property type="gene ID" value="Gmet_1879"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1879"/>
    <dbReference type="eggNOG" id="COG0119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022158_7_0_7"/>
    <dbReference type="OMA" id="KSWDFHV"/>
    <dbReference type="OrthoDB" id="840579at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00066"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043714">
        <property type="term" value="F:(R)-citramalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005675">
        <property type="entry name" value="Citramal_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43538">
        <property type="entry name" value="PTHR43538"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="SSF110921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00977">
        <property type="entry name" value="citramal_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00815">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="10">
        <location>
            <begin position="4"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB32108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="528" mass="59135" checksum="34FBD2EA9133D107" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UH9</accession>
    <name>Q39UH9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1866"/>
    <dbReference type="EnsemblBacteria" id="ABB32095">
        <property type="protein sequence ID" value="ABB32095"/>
        <property type="gene ID" value="Gmet_1866"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1866"/>
    <dbReference type="HOGENOM" id="CLU_147927_0_0_7"/>
    <dbReference type="OMA" id="CAITCHA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223411" evidence="1">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="142" mass="15275" checksum="0FBFB34F29C0DDD5" modified="2005-11-22" version="1">MSFVKQGIGACVAVLVLSGTGIAAPEVPDGAVNPHTSPESCGVCHVLPKEKLGSFFVANATKRQLLTNQVALCRQCHGMEFGHGIGMKPEMNRESLPLAEDGTITCAITCHAMHVKNPGNQEQERYHLRLPLSKICLSCHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UI9</accession>
    <name>Q39UI9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Cell division ATP-binding protein FtsE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 9" type="primary">ftsE</name>
        <name evidence="9" type="ordered locus">Gmet_1856</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer. Forms a membrane-associated complex with FtsX.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ABC transporter superfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511990.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1856"/>
    <dbReference type="EnsemblBacteria" id="ABB32085">
        <property type="protein sequence ID" value="ABB32085"/>
        <property type="gene ID" value="Gmet_1856"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1856"/>
    <dbReference type="eggNOG" id="COG2884">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="ALINCPK"/>
    <dbReference type="OrthoDB" id="1181903at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007049">
        <property type="term" value="P:cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005286">
        <property type="entry name" value="Cell_div_FtsE_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02673">
        <property type="entry name" value="FtsE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="2"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="223" mass="24735" checksum="1F2D780A4B34C504" modified="2005-11-22" version="1">MIQFHNVFLSYQSDAAALNDVSLKVPKGDFVFVTGPSGAGKSTLLKLVYGALSPSRGQVLVDGQNITRLTRTQIPLLRRTIGVVFQDFKLLPNRTVLENVAITLEVLGWSKRDIGKKVYHVLKQMGIEHKINATPLRLSGGEQQRVALARALVNEPKILLADEPTGNLDDENKEQILSIFREANIKGTTVVVATHDRRVIENSHRRVIVLDRGRVAEDTDVPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UK3</accession>
    <name>Q39UK3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dihydroorotate dehydrogenase B (NAD(+)), electron transfer subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Dihydroorotate oxidase B, electron transfer subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5 9" type="primary">pyrK</name>
        <name evidence="9" type="ordered locus">Gmet_1842</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 7">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="5 7">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="5 6">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; orotate from (S)-dihydroorotate (NAD(+) route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer of 2 PyrK and 2 PyrD type B subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PyrK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512004.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1842"/>
    <dbReference type="EnsemblBacteria" id="ABB32071">
        <property type="protein sequence ID" value="ABB32071"/>
        <property type="gene ID" value="Gmet_1842"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1842"/>
    <dbReference type="eggNOG" id="COG0543">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003827_1_2_7"/>
    <dbReference type="OMA" id="RYMKCGI"/>
    <dbReference type="OrthoDB" id="1885467at2"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00945"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01211">
        <property type="entry name" value="DHODB_Fe_S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012165">
        <property type="entry name" value="Cyt_c3_hydrogenase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037117">
        <property type="entry name" value="Dihydroorotate_DH_ele_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019480">
        <property type="entry name" value="Dihydroorotate_DH_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023455">
        <property type="entry name" value="Dihydroorotate_DHASE_ETsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10418">
        <property type="entry name" value="DHODB_Fe-S_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006816">
        <property type="entry name" value="Cyc3_hyd_g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="SSF52343"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="SSF63380"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="5 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="5 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5 6">
        <location>
            <begin position="84"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5 7">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR006816-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="271" mass="29649" checksum="FA0CDDE5B96B3C5E" modified="2005-11-22" version="1">MQFKATIISNQEVSPGYFRMRITAHPELTGAQPGQFVMVRVRDAIDPLLRRPFGIFDVGTVPSEYPGCSSATYLEMLYKVVGKGTETLSTYHHGDHVDIIAPLGTGFDLGDPEEEKILVGGGVGIAPLYYLAKTLVGRSRVRFFLGGRTRDDILCVTEFERLGVETYVSTDDGTLGDRGLVTDVMERHVREDGRKKTIYACGPMPMLKAVAGIARQTGTSCQVSLEAYMACGMGACLGCVVKGRDHGDETPDYRCVCKDGPVFAFDQLMWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UL3</accession>
    <name>Q39UL3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Peptidoglycan-binding protein, OmpA family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512014.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1832"/>
    <dbReference type="EnsemblBacteria" id="ABB32061">
        <property type="protein sequence ID" value="ABB32061"/>
        <property type="gene ID" value="Gmet_1832"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1832"/>
    <dbReference type="eggNOG" id="COG2885">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_520496_0_0_7"/>
    <dbReference type="OMA" id="QRHVSED"/>
    <dbReference type="OrthoDB" id="583204at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07185">
        <property type="entry name" value="OmpA_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006664">
        <property type="entry name" value="OMP_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006665">
        <property type="entry name" value="OmpA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036737">
        <property type="entry name" value="OmpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00691">
        <property type="entry name" value="OmpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01021">
        <property type="entry name" value="OMPADOMAIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103088">
        <property type="entry name" value="SSF103088"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51123">
        <property type="entry name" value="OMPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223313" evidence="3">
        <location>
            <begin position="21"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="OmpA-like" evidence="4">
        <location>
            <begin position="402"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="523" mass="56040" checksum="F1398ACDC384E44D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UR3</accession>
    <name>Q39UR3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamyl-Q tRNA(Asp) synthetase</fullName>
            <shortName evidence="5">Glu-Q-RSs</shortName>
            <ecNumber evidence="5">6.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gluQ</name>
        <name evidence="8" type="synonym">yadB</name>
        <name evidence="8" type="ordered locus">Gmet_1780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513323.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1780"/>
    <dbReference type="EnsemblBacteria" id="ABB32011">
        <property type="protein sequence ID" value="ABB32011"/>
        <property type="gene ID" value="Gmet_1780"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1780"/>
    <dbReference type="eggNOG" id="COG0008">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015768_0_1_7"/>
    <dbReference type="OMA" id="WLLRMED"/>
    <dbReference type="OrthoDB" id="1409413at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01428">
        <property type="entry name" value="Glu_Q_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022380">
        <property type="entry name" value="Glu-Q_tRNA(Asp)_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03838">
        <property type="entry name" value="queuosine_YadB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 5 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-synt_1c" evidence="7">
        <location>
            <begin position="12"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Glutamate binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region" evidence="5">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region" evidence="5">
        <location>
            <begin position="244"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="314" mass="33562" checksum="8C3DF1BC2BBB8E9B" modified="2005-11-22" version="1">MMSEQIPDNRSVVGRFAPSPTGPLHLGSLVAAVGSYAMAKREGGLWLLRMEDLDTPRVVPGMADDMFRTLEALGFAWDGEVMWQSRRSDAYSAAFERLLAIGEAYPCGCSRAEIARAASAPHDGEGEVAYPNICRNGLQPGKEPRSYRVKVGSEPIVVRDLVMGEKRYDLSQICGDFVVKRADGLFAYQLAVVVDDADQGVNQVVRGADLLSSTPRQILLQSLLDYETPVYAHLPLVTAAGGGKLSKRDNAVSLAAGLDLAVEGGRLILAALRFLGQRPPESLAGSNGKEVLAWGAANFDIALVPTASAPLSVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UX0</accession>
    <name>Q39UX0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513380.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1723"/>
    <dbReference type="EnsemblBacteria" id="ABB31954">
        <property type="protein sequence ID" value="ABB31954"/>
        <property type="gene ID" value="Gmet_1723"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1723"/>
    <dbReference type="eggNOG" id="ENOG502ZA7Y">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116203_0_0_7"/>
    <dbReference type="OMA" id="YAFLNIQ"/>
    <dbReference type="OrthoDB" id="1897347at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="191" mass="21730" checksum="B4D301EC179A68D0" modified="2005-11-22" version="1">MSSETDFKRYSVAPIGAGDEGIQLLQGLSKEELIRIIVDDAKNWLAHDGLWFQAVEKRYGIDVAIDADTEAWRYFTVIEAKRIMERLGIQPGGGIPALVECLKHRLYARLNLQDVIEQSDDRVAFRMLDCRVQSARRRKGLPDFPCKSVGLVEYAEFARTVDPRIRTSCIACPPDAHPDAFWCAWEFVVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UY9</accession>
    <name>Q39UY9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">[lipopolysaccharide]-lipid A 3-O-deacylase outer membrane protein, PagL family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514150.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1704"/>
    <dbReference type="EnsemblBacteria" id="ABB31935">
        <property type="protein sequence ID" value="ABB31935"/>
        <property type="gene ID" value="Gmet_1704"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1704"/>
    <dbReference type="eggNOG" id="COG3637">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_118029_0_0_7"/>
    <dbReference type="OMA" id="GITHRGF"/>
    <dbReference type="OrthoDB" id="1863236at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018550">
        <property type="entry name" value="Lipid-A_deacylase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011250">
        <property type="entry name" value="OMP/PagP_b-brl"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09411">
        <property type="entry name" value="PagL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56925">
        <property type="entry name" value="SSF56925"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223303" evidence="1">
        <location>
            <begin position="25"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="200" mass="21727" checksum="01756F8F4ECA7ED5" modified="2005-11-22" version="1">MKPYPCLVAFLVSGSLLATSPCSAAESPSVATAGHEWAFLAGYGITHRGFGATRTQVQTADAIGRFGWFLSDEVGKGSWYQGRHELLVELPIHLAVDQRDRIMTGGYLLGSWKFTGLADEKLYPYVFAGGGVLFVDLGLPTMGTRLDFSYQGGTGIQYLIGKDTAIMGEYRYHHVSNAGTAEPNEPLNSSKFLVGVSWFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V72</accession>
    <name>Q39V72_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511443.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1621"/>
    <dbReference type="EnsemblBacteria" id="ABB31852">
        <property type="protein sequence ID" value="ABB31852"/>
        <property type="gene ID" value="Gmet_1621"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1621"/>
    <dbReference type="eggNOG" id="COG1186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_089470_5_0_7"/>
    <dbReference type="OMA" id="IKVEFYR"/>
    <dbReference type="OrthoDB" id="2047548at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="SSF75620"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RF_PROK_I" evidence="3">
        <location>
            <begin position="2"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="75"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="107" mass="12547" checksum="21979F672940C116" modified="2005-11-22" version="1">MIEINEADLKFEFYRGSGPGGQHRNVTESGVRIRHVPTGVVVQACESRSQARNREIALERLRQILERRERRVKKRVATTVPRGQKEKRIEEKKRRSLTKRLRTPSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V78</accession>
    <name>Q39V78_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Archease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1615</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the archease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511449.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1615"/>
    <dbReference type="EnsemblBacteria" id="ABB31846">
        <property type="protein sequence ID" value="ABB31846"/>
        <property type="gene ID" value="Gmet_1615"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1615"/>
    <dbReference type="eggNOG" id="COG1371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_111362_3_0_7"/>
    <dbReference type="OMA" id="KAVTWHA"/>
    <dbReference type="OrthoDB" id="1786857at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002804">
        <property type="entry name" value="Archease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023572">
        <property type="entry name" value="Archease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036820">
        <property type="entry name" value="Archease_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12682">
        <property type="entry name" value="PTHR12682"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01951">
        <property type="entry name" value="Archease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69819">
        <property type="entry name" value="SSF69819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Archease" evidence="5">
        <location>
            <begin position="3"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="143" mass="16216" checksum="56A9A8C0DA0BF2EB" modified="2005-11-22" version="1">MPYRYLPDIATADTAFEATGATREEMFTAAADALTNVMVEDLATIQPRQELEIILENADLDLLLFDFLQEIIYYKDARRLLLRPSSLTIADSDAILKLHTVVRGEEIDLDRHPMVVDVKAVTLHRFAVELRDGTWRATVVLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V86</accession>
    <name>Q39V86_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein phosphoaspartate phosphatase CheX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cheX-4</name>
        <name evidence="3" type="ordered locus">Gmet_1606</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511459.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1606"/>
    <dbReference type="EnsemblBacteria" id="ABB31838">
        <property type="protein sequence ID" value="ABB31838"/>
        <property type="gene ID" value="Gmet_1606"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1606"/>
    <dbReference type="eggNOG" id="COG1406">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_052003_0_0_7"/>
    <dbReference type="OMA" id="DTVMEFV"/>
    <dbReference type="OrthoDB" id="1051427at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028976">
        <property type="entry name" value="CheC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028051">
        <property type="entry name" value="CheX-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13690">
        <property type="entry name" value="CheX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103039">
        <property type="entry name" value="SSF103039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CheX" evidence="2">
        <location>
            <begin position="174"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="287" mass="31638" checksum="0CD686D7C3F310DE" modified="2005-11-22" version="1">MAVKFFGQFLVEKGVVSRETLLQAIELQESVNLSFGATSLAMGILTEADIERIHNAQRIEDLRFGDMAVKLGLLTSEQMMQVLTRQKNTHLYIGEALVKVGSFQADELPKYLEEFKADQAQYATDTVVIPTGVSEPKIWEMVADLSYKMLTRVALLVFRPEPCFVADRVPAMDVYATMDFTGDISGRYFMGVTAATQKKIAKAILKEPNVDNEPKEILDDTVMEFVNVALGNIAAKAAQSGKSMEIAPPEIIEAPDGIQVPDGHKALCFPVCLSDGDRIELAVFIQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-02-05" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V90</accession>
    <name>ACP_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Acyl carrier protein</fullName>
            <shortName evidence="1">ACP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">acpP</name>
        <name type="ordered locus">Gmet_1602</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511463.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39V90"/>
    <dbReference type="SMR" id="Q39V90"/>
    <dbReference type="STRING" id="269799.Gmet_1602"/>
    <dbReference type="EnsemblBacteria" id="ABB31834">
        <property type="protein sequence ID" value="ABB31834"/>
        <property type="gene ID" value="Gmet_1602"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1602"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_5_1_7"/>
    <dbReference type="OMA" id="CEIPDEQ"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="Acyl_carrier"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="PTHR20863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword id="KW-0276">Fatty acid metabolism</keyword>
    <keyword id="KW-0444">Lipid biosynthesis</keyword>
    <keyword id="KW-0443">Lipid metabolism</keyword>
    <keyword id="KW-0596">Phosphopantetheine</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000066612" description="Acyl carrier protein">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="2">
        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="2">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00258"/>
        </source>
    </evidence>
    <sequence length="77" mass="8563" checksum="9560B24FCCD9CDC6" modified="2005-11-22" version="1">MSAIDKRVKEIVAEQLGVDEAQVTNEASFMDDLGADSLDTVELVMALEEEFDIEISDEDAEKIQSVQDAIDYITEHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VC3</accession>
    <name>Q39VC3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc-dependent isopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1569</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511496.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1569"/>
    <dbReference type="EnsemblBacteria" id="ABB31801">
        <property type="protein sequence ID" value="ABB31801"/>
        <property type="gene ID" value="Gmet_1569"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1569"/>
    <dbReference type="eggNOG" id="COG1310">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116765_1_1_7"/>
    <dbReference type="OMA" id="GAHYVLV"/>
    <dbReference type="OrthoDB" id="1811367at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070122">
        <property type="term" value="F:isopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028090">
        <property type="entry name" value="JAB_dom_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14464">
        <property type="entry name" value="Prok-JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="132" mass="14241" checksum="D151E4BA308A0F8D" modified="2005-11-22" version="1">MLTIPRAIHAELIAHAQADAPIEACGILGGIDGAVSAIFRMANTDQSDEHFMMDPKEQFAVVKELRNRGLAMLAIYHSHPETPARPSEEDIRLALTPGVSYVIASLAGAEPDVKAFRITDGVVEPEPIDIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VI9</accession>
    <name>Q39VI9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Hepar_II_III_N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365837.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1501"/>
    <dbReference type="EnsemblBacteria" id="ABB31735">
        <property type="protein sequence ID" value="ABB31735"/>
        <property type="gene ID" value="Gmet_1501"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1501"/>
    <dbReference type="eggNOG" id="COG5360">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022012_3_0_7"/>
    <dbReference type="OMA" id="HLFANAK"/>
    <dbReference type="OrthoDB" id="442785at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008929">
        <property type="entry name" value="Chondroitin_lyas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012480">
        <property type="entry name" value="Hepar_II_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031680">
        <property type="entry name" value="Hepar_II_III_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07940">
        <property type="entry name" value="Hepar_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16889">
        <property type="entry name" value="Hepar_II_III_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48230">
        <property type="entry name" value="SSF48230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hepar_II_III_N" evidence="1">
        <location>
            <begin position="114"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="561" mass="63734" checksum="A71BDA35382FA47E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="49" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VL4</accession>
    <name>Q39VL4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511592.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1476"/>
    <dbReference type="EnsemblBacteria" id="ABB31710">
        <property type="protein sequence ID" value="ABB31710"/>
        <property type="gene ID" value="Gmet_1476"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1476"/>
    <dbReference type="eggNOG" id="COG1361">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1022170_0_0_7"/>
    <dbReference type="OrthoDB" id="91949at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="272" mass="29663" checksum="6C3B2B02A100790A" modified="2005-11-22" version="1">MKTEEVLPQKERGRNEGRFPYCLVRREETRDTSHIIRESLISPQLLSGTAATTLAANSFQDIPVTYLADVHGTQSASINMGFTYDGMTYSATNYLPLQGQAIYKPDFTGSYGFNYGTPYLANPVDGTVRLVNAGSQPLTVTGVSITGADAVRFQITGGNQNGNLSPGQYRDINVRYLANSVATHSANVNVSYTYDGVANTQDLGLSGQTLSTPVAQLWLDDTMIAERKRGTLPIFNRSLATLNPNVSSNFWPSLRSHKLFSHLPLSCNRALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VR9</accession>
    <name>Q39VR9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase sigma-38 factor, stationary phase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">rpoS</name>
        <name evidence="7" type="ordered locus">Gmet_1421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511646.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1421"/>
    <dbReference type="EnsemblBacteria" id="ABB31655">
        <property type="protein sequence ID" value="ABB31655"/>
        <property type="gene ID" value="Gmet_1421"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1421"/>
    <dbReference type="eggNOG" id="COG0568">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014793_3_5_7"/>
    <dbReference type="OMA" id="RRVQREF"/>
    <dbReference type="OrthoDB" id="1565734at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016987">
        <property type="term" value="F:sigma factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription, initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014284">
        <property type="entry name" value="RNA_pol_sigma-70_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000943">
        <property type="entry name" value="RNA_pol_sigma70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009042">
        <property type="entry name" value="RNA_pol_sigma70_r1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007627">
        <property type="entry name" value="RNA_pol_sigma70_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007624">
        <property type="entry name" value="RNA_pol_sigma70_r3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007630">
        <property type="entry name" value="RNA_pol_sigma70_r4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013325">
        <property type="entry name" value="RNA_pol_sigma_r2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013324">
        <property type="entry name" value="RNA_pol_sigma_r3/r4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00140">
        <property type="entry name" value="Sigma70_r1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04542">
        <property type="entry name" value="Sigma70_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04539">
        <property type="entry name" value="Sigma70_r3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04545">
        <property type="entry name" value="Sigma70_r4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00046">
        <property type="entry name" value="SIGMA70FCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88659">
        <property type="entry name" value="SSF88659"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88946">
        <property type="entry name" value="SSF88946"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02937">
        <property type="entry name" value="sigma70-ECF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00715">
        <property type="entry name" value="SIGMA70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0731">Sigma factor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="RNA_pol_sigma70" evidence="6">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="326" mass="38075" checksum="3FE12B8D76ABB467" modified="2005-11-22" version="1">MDDFLEKEAVEPEEHAERQPDDFLEPEPTSFEYEEAEEEEEQEEEIKVVEVEHFDDAIKLYLREIQRTTLLTADEEKVLASRIAKGDKAARDKMIESNLRLVVKIAKRYINRGLPFLDLIEEGNMGLIKAVERFKLSKECRFSTYATWWIRQSIERALVNQSRTIRLPVHVSDDINKMLKITRELVNRFNREPTVKEVATEMNVNSAYIRRLMVLLKKTYSIERPMGENSDYFLIDTIEDTSSVSPAVLLEDLNKYEIVSKWFASLSENEQKILTLRFGLEDKEPQTLDTIGRSFGVTRERIRQIEAKSLEKLRKYIDNSDGSAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VW7</accession>
    <name>Q39VW7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513135.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1373"/>
    <dbReference type="EnsemblBacteria" id="ABB31607">
        <property type="protein sequence ID" value="ABB31607"/>
        <property type="gene ID" value="Gmet_1373"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1373"/>
    <dbReference type="eggNOG" id="COG3762">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086382_0_1_7"/>
    <dbReference type="OMA" id="VWILGDR"/>
    <dbReference type="OrthoDB" id="1927539at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="211" mass="24092" checksum="659E2B5A0F86838B" modified="2005-11-22" version="1">MKRAEEFFTPKERERVRAAVAETERGTSGEIATMVVDASDSYREAEILGAVLLSGLLSVIVAVTIHHVTIWSYIPLVVLLYFPSWYLFRRAPRLKLPFAGRRRLAEAVRERAVRAFYEKGLYRTREETGILIFISLLEHKVWILGDRGINKKIDPRFWQELAAQLARGLREGRACDVLCSVVAGCGAELARHFPHRADDVNELQDEILTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VZ8</accession>
    <name>Q39VZ8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1341</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1341"/>
    <dbReference type="EnsemblBacteria" id="ABB31576">
        <property type="protein sequence ID" value="ABB31576"/>
        <property type="gene ID" value="Gmet_1341"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1341"/>
    <dbReference type="eggNOG" id="COG1629">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033718_0_0_7"/>
    <dbReference type="OMA" id="RYSHWFS"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026950">
        <property type="entry name" value="Caps_assemb_Wzi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038636">
        <property type="entry name" value="Wzi_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14052">
        <property type="entry name" value="Caps_assemb_Wzi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="559" mass="61253" checksum="C4D76AC6A6F9DE2D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W01</accession>
    <name>Q39W01_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD-dependent nucleoside diphosphate-sugar epimerase/dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1338</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polysaccharide synthase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31573.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365812.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1338"/>
    <dbReference type="EnsemblBacteria" id="ABB31573">
        <property type="protein sequence ID" value="ABB31573"/>
        <property type="gene ID" value="Gmet_1338"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1338"/>
    <dbReference type="eggNOG" id="COG1086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013560_5_0_7"/>
    <dbReference type="OMA" id="IIIAMPS"/>
    <dbReference type="OrthoDB" id="662797at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05237">
        <property type="entry name" value="UDP_invert_4-6DH_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003869">
        <property type="entry name" value="Polysac_CapD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02719">
        <property type="entry name" value="Polysacc_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Polysacc_synt_2" evidence="3">
        <location>
            <begin position="282"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31573.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="639" mass="70938" checksum="CE92F4E0C7B001BB" modified="2012-10-31" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W29</accession>
    <name>Q39W29_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">2-oxoacid:ferredoxin oxidoreductase, gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">vorC</name>
        <name evidence="3" type="ordered locus">Gmet_1309</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512057.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1309"/>
    <dbReference type="EnsemblBacteria" id="ABB31545">
        <property type="protein sequence ID" value="ABB31545"/>
        <property type="gene ID" value="Gmet_1309"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1309"/>
    <dbReference type="eggNOG" id="COG1014">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087284_0_1_7"/>
    <dbReference type="OMA" id="RMANMVA"/>
    <dbReference type="OrthoDB" id="1777574at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="SSF53323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POR" evidence="2">
        <location>
            <begin position="11"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="184" mass="19371" checksum="010C6E35AAAD8A10" modified="2005-11-22" version="1">MRHDVFISGFGGQGVLLAGNLLGYAAMGEGKNVSFYPSYGVEKRGGAAMCTVVIADGEVGSPVVGNPSVSVILNQTSFDKYASRVKPGGVCIVNTSLVEIGDFSRSDIELIPIPMNEIAMQLGDLRMVNMVAVGAYAAKTGAVSLQSLEGALRKTLPERNHRFIPANVRAIEAGAQRSGSHFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W37</accession>
    <name>Q39W37_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1301</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512065.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1301"/>
    <dbReference type="EnsemblBacteria" id="ABB31537">
        <property type="protein sequence ID" value="ABB31537"/>
        <property type="gene ID" value="Gmet_1301"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1301"/>
    <dbReference type="eggNOG" id="COG4259">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2450402_0_0_7"/>
    <dbReference type="OMA" id="TGIYNFY"/>
    <dbReference type="OrthoDB" id="1961376at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="89" mass="9910" checksum="96219326516266D1" modified="2005-11-22" version="1">MNKRFLVALCLVVACLAGCSLPPEKPVTKDELYATGIYNFYTIKESPESVLAAINREGEVILDARYRDRPVFIKILALSSGLQVHVIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="109" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W49</accession>
    <name>Q39W49_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Phosphoenolpyruvate-protein phosphotransferase</fullName>
            <ecNumber evidence="5 13">2.7.3.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Phosphotransferase system, enzyme I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="primary">ptsI</name>
        <name evidence="20" type="ordered locus">Gmet_1289</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="20 21" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>L-histidyl-[protein] + phosphoenolpyruvate = N(pros)-phospho-L-histidyl-[protein] + pyruvate</text>
            <dbReference type="Rhea" id="RHEA:23880"/>
            <dbReference type="Rhea" id="RHEA-COMP:9745"/>
            <dbReference type="Rhea" id="RHEA-COMP:9746"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:64837"/>
            <dbReference type="EC" id="2.7.3.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 13 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <dbReference type="EC" id="2.7.3.9" evidence="5 13"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512077.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1289"/>
    <dbReference type="EnsemblBacteria" id="ABB31525">
        <property type="protein sequence ID" value="ABB31525"/>
        <property type="gene ID" value="Gmet_1289"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1289"/>
    <dbReference type="eggNOG" id="COG1080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007308_7_0_7"/>
    <dbReference type="OMA" id="CNAEWAL"/>
    <dbReference type="OrthoDB" id="467393at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008965">
        <property type="term" value="F:phosphoenolpyruvate-protein phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009401">
        <property type="term" value="P:phosphoenolpyruvate-dependent sugar phosphotransferase system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008279">
        <property type="entry name" value="PEP-util_enz_mobile_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018274">
        <property type="entry name" value="PEP_util_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000121">
        <property type="entry name" value="PEP_util_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023151">
        <property type="entry name" value="PEP_util_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036637">
        <property type="entry name" value="Phosphohistidine_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024692">
        <property type="entry name" value="PTS_EI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006318">
        <property type="entry name" value="PTS_EI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008731">
        <property type="entry name" value="PTS_EIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036618">
        <property type="entry name" value="PtsI_HPr-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05524">
        <property type="entry name" value="PEP-utilisers_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00391">
        <property type="entry name" value="PEP-utilizers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02896">
        <property type="entry name" value="PEP-utilizers_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000732">
        <property type="entry name" value="PTS_enzyme_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47831">
        <property type="entry name" value="SSF47831"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52009">
        <property type="entry name" value="SSF52009"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01417">
        <property type="entry name" value="PTS_I_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00742">
        <property type="entry name" value="PEP_ENZYMES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00370">
        <property type="entry name" value="PEP_ENZYMES_PHOS_SITE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0598">Phosphotransferase system</keyword>
    <keyword evidence="20" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="13 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PEP-utilisers_N" evidence="19">
        <location>
            <begin position="12"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers" evidence="17">
        <location>
            <begin position="166"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PEP-utilizers_C" evidence="18">
        <location>
            <begin position="265"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="PEP binding" evidence="15">
        <location>
            <begin position="464"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="14">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="475"/>
        </location>
        <ligand>
            <name>phosphoenolpyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR000732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000732-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF05524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="ABB31525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="588" mass="64859" checksum="4D80EB3A3FB954D5" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="95" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WE2</accession>
    <name>Q39WE2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine protease, subtilase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_1195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512175.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1195"/>
    <dbReference type="EnsemblBacteria" id="ABB31432">
        <property type="protein sequence ID" value="ABB31432"/>
        <property type="gene ID" value="Gmet_1195"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1195"/>
    <dbReference type="eggNOG" id="COG1404">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011263_15_6_7"/>
    <dbReference type="OMA" id="RFTDYVP"/>
    <dbReference type="OrthoDB" id="923655at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07473">
        <property type="entry name" value="Peptidases_S8_Subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034204">
        <property type="entry name" value="PfSUB1-like_cat_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="SSF52743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223460" evidence="6">
        <location>
            <begin position="26"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_S8" evidence="7">
        <location>
            <begin position="142"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="519" mass="54835" checksum="1D084F99266AB930" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WE6</accession>
    <name>Q39WE6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512179.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1191"/>
    <dbReference type="EnsemblBacteria" id="ABB31428">
        <property type="protein sequence ID" value="ABB31428"/>
        <property type="gene ID" value="Gmet_1191"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1191"/>
    <dbReference type="eggNOG" id="COG0810">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_112402_0_0_7"/>
    <dbReference type="OMA" id="CHGASKQ"/>
    <dbReference type="OrthoDB" id="2201536at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223370" evidence="2">
        <location>
            <begin position="28"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="184" mass="18747" checksum="6476B54EFE645CD5" modified="2005-11-22" version="1">MSKTLKMAVLFLALTIGQTAVIPSGHADDDYATKIKKASQEKAEKEKKEREKKEKESKNHKPAPIPRPNPTPVPPTPAPAPKPIPAPAPKPTPAPTPAPTPAPAPAPAPTPVPAPTPAPTPAPAPVPAKTWALYNQYCAGCHGASKQGKTAAAIQSAISGNIGGMGYLSSSLTAAQITSLAAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WI8</accession>
    <name>Q39WI8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rubredoxin reductase, selenocysteine-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_1148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1148"/>
    <dbReference type="KEGG" id="gme:Gmet_1148"/>
    <dbReference type="eggNOG" id="COG0446">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_003291_1_3_7"/>
    <dbReference type="OMA" id="WVSHAPC"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="SSF55424"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0711">Selenium</keyword>
    <keyword evidence="4" id="KW-0712">Selenocysteine</keyword>
    <feature type="domain" description="Pyr_redox_2" evidence="3">
        <location>
            <begin position="5"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Pyr_redox_dim" evidence="2">
        <location>
            <begin position="333"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="non-standard amino acid" description="Selenocysteine" evidence="4">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="451" mass="47905" checksum="4FC181611BE62E23" modified="2008-02-26" version="2">MAKEKLVVIGGDAAGMSAASQAKRRRPELEIVVFERSPHTSFSAUGIPYYVGRVVDKEEKLVIRSPEKFREKYGIDARALHEVVEIDAAQGKVRVRDLQRGGSAWESYDQLLIATGAVPLCPDLPGSDAVDICGVNTLESGLEIRRRLDKGGMKKGVVVGGGYIGLEMAEALVRHGLEVSLVNRAPQVMGTLDYDMGAMVSQALRDVGVSLYLEETLTAFETKGGKVTGVVTDRRTLPADIVILGLGVRPNTALASAAGIPLGEKGSIRVNERMQTGVAGIWAAGDCAESFHLVSRKPVHIALGTVANRHGRVAGINLGGGYATFPGVVGTAVTKICQVEVARTGLQEEELRELGIEWISAVIKSRTRAGYFPGAGGITVKVLAERGSGRLLGGQIVGMEGSAKRIDTLATALHAGFTVEEMINLDLGYAPPFSPVWDPVVIAAREVAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="131" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WQ1</accession>
    <name>Q39WQ1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histidine kinase</fullName>
            <ecNumber evidence="4">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ordered locus">Gmet_1083</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="13 14" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513739.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1083"/>
    <dbReference type="EnsemblBacteria" id="ABB31323">
        <property type="protein sequence ID" value="ABB31323"/>
        <property type="gene ID" value="Gmet_1083"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1083"/>
    <dbReference type="eggNOG" id="COG2202">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_51_7"/>
    <dbReference type="OMA" id="WMEWVAT"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033463">
        <property type="entry name" value="sCache_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029151">
        <property type="entry name" value="Sensor-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17202">
        <property type="entry name" value="sCache_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103190">
        <property type="entry name" value="SSF103190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="11">
        <location>
            <begin position="349"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="415"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="12">
        <location>
            <begin position="543"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="740"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="ABB31323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="986" mass="110271" checksum="9F0CDA9F21524688" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WR0</accession>
    <name>Q39WR0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513730.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1074"/>
    <dbReference type="EnsemblBacteria" id="ABB31314">
        <property type="protein sequence ID" value="ABB31314"/>
        <property type="gene ID" value="Gmet_1074"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1074"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_070764_7_3_7"/>
    <dbReference type="OMA" id="WEEDCSA"/>
    <dbReference type="OrthoDB" id="1847197at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="167" mass="18501" checksum="E2E4E1BF6F0B303A" modified="2005-11-22" version="1">MEVLEAIYGRRSVRQYTSEPVTREEVLEIVQAGSWAPSGLNNQPWRFAIVSDDEKRRALAGFTKYRHILEGAPVSIAVFCDRAAMYNDTKDHQSVGACLQNMLLAAHALGLGAVWLGEILKSADKVRELLALPESLELMAVVAVGRPAEFTRTGDRKDLDELIVGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X00</accession>
    <name>Q39X00_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Prolidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514377.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0982"/>
    <dbReference type="MEROPS" id="M24.008"/>
    <dbReference type="EnsemblBacteria" id="ABB31224">
        <property type="protein sequence ID" value="ABB31224"/>
        <property type="gene ID" value="Gmet_0982"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0982"/>
    <dbReference type="eggNOG" id="COG0006">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017266_4_0_7"/>
    <dbReference type="OMA" id="YCSDRTR"/>
    <dbReference type="OrthoDB" id="415910at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046914">
        <property type="term" value="F:transition metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_NTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="SSF53092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="SSF55920"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase_N" evidence="6">
        <location>
            <begin position="5"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_M24" evidence="5">
        <location>
            <begin position="138"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="357" mass="38675" checksum="8101638E0E4EF56B" modified="2005-11-22" version="1">MLQNRIIKARGCAEKQDVDAILFFNLSNVRYLAGFTGSDGVLVVGRDSCWFLTDSRYTTQAAREVTGCSTVEYRVKLDGIAELCASQGFRRVGFEAEHTTVALLTALTTKVSGVEFVPLGEELAPLRIVKDAEEIDLLAETARIASEALLASLDGLKPGVVEREYALDLEFAMRRAGTDDKSFDFIVASGERGALPHGRASTKVIGAGELVTIDFGAIFRGYHSDETVTVCVGEPDDRQREIYGIVKEAHDRALAAVRPGVSFKELDAIARGFIEERGYGAFFGHGLGHGVGLDVHEKPVVSPRGEGVAEEGMVFTIEPGIYIPQWGGVRIEDAVAVTGNGYRLLTRVPKELIILNP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X01</accession>
    <name>AROQ_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">3-dehydroquinate dehydratase</fullName>
            <shortName evidence="1">3-dehydroquinase</shortName>
            <ecNumber evidence="1">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Type II DHQase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">aroQ</name>
        <name type="ordered locus">Gmet_0981</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes a trans-dehydration via an enolate intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homododecamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514376.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X01"/>
    <dbReference type="SMR" id="Q39X01"/>
    <dbReference type="STRING" id="269799.Gmet_0981"/>
    <dbReference type="EnsemblBacteria" id="ABB31223">
        <property type="protein sequence ID" value="ABB31223"/>
        <property type="gene ID" value="Gmet_0981"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0981"/>
    <dbReference type="eggNOG" id="COG0757">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090968_1_0_7"/>
    <dbReference type="OMA" id="AYTHYSY"/>
    <dbReference type="OrthoDB" id="1872106at2"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00086"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:cellular amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="PTHR21272"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="SSF52304"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000023467" description="3-dehydroquinate dehydratase">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="100"/>
            <end position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00169"/>
        </source>
    </evidence>
    <sequence length="150" mass="16067" checksum="42C64938A5237D33" modified="2005-11-22" version="1">MNVLVVHGPNLNLLGTREPGIYGVLTLDRINEEISALAEELGCSVSFFQSNSEGAIIDAIQQACGACDGILINPAAYTHTSVAIRDALAAVALPVVEVHLSNIHRREEFRHHSFIAPVAVGQIAGFGADSYLLGLRALFTYIKKEIVTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X02</accession>
    <name>Q39X02_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GTPase-activating protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514375.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0980"/>
    <dbReference type="EnsemblBacteria" id="ABB31222">
        <property type="protein sequence ID" value="ABB31222"/>
        <property type="gene ID" value="Gmet_0980"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0980"/>
    <dbReference type="eggNOG" id="COG2018">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161433_1_0_7"/>
    <dbReference type="OMA" id="LACSVMG"/>
    <dbReference type="OrthoDB" id="1643542at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Robl_LC7" evidence="1">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="120" mass="13040" checksum="B733FDE641B58E91" modified="2005-11-22" version="1">MPFSETLKSIVESVGGGLGAVIMADDGIAIDEYLLDGSGMDLNLMAVEYASLLKEVKRMADVLKTGSLEEMAVNTGRSQVIVRTINDELFIALILGQDGNCGKGRYLLRREVFGLRERLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X13</accession>
    <name>Q39X13_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0969</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0969"/>
    <dbReference type="EnsemblBacteria" id="ABB31211">
        <property type="protein sequence ID" value="ABB31211"/>
        <property type="gene ID" value="Gmet_0969"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0969"/>
    <dbReference type="HOGENOM" id="CLU_1445748_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="187" mass="21372" checksum="8CF7AC6E6D20115F" modified="2005-11-22" version="1">MNMGKPVRKTGRTIAVLVVIILGAASIYVVATWPYNVVGWMTYRILGKPFPSRVTELQNIKRFLDAKRKLNKKEYDAAFQGLQYLRQNVAVTFPFFKEIYLYLGYIHDLRGDLRGEEALHRELETKDKVFALFLEGLYAIRHGRDVEGKGYLAESIKLDNQFNRLGKYRGVALKALGTAALPRKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X43</accession>
    <name>Q39X43_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Replication-associated recombination protein A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">rarA</name>
        <name evidence="5" type="ordered locus">Gmet_0939</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514422.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0939"/>
    <dbReference type="EnsemblBacteria" id="ABB31181">
        <property type="protein sequence ID" value="ABB31181"/>
        <property type="gene ID" value="Gmet_0939"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0939"/>
    <dbReference type="eggNOG" id="COG2256">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_017985_0_3_7"/>
    <dbReference type="OMA" id="RIILSQC"/>
    <dbReference type="OrthoDB" id="977094at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="4">
        <location>
            <begin position="52"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="441" mass="48858" checksum="44BD3249DF9B084E" modified="2005-11-22" version="1">MTDLFDATAATETGRDAPLAERMRPRTLDDYVGQEHLLGEGKLLRRLIESDTLSSLIFWGPPGSGKTTLARIIANATKSHFIFFSAILSGVKEIREIVKEAENERKYRGSNTILFVDEIHRFNKSQQDAFLPYVEKGVFTIIGATTENPSFEVIAPLLSRCKVLVLNSLTDEEVTTILRRALVDPERGLGNRSLAVSDEALAFMAEQAQGDARIALNTLETAARLAKNGEIDLDSAREAAQKKALLYDKGGEEHYNVISAFIKSMRGSDPDGALYWLARMIEAGEDPLFILRRMVILASEDIGNADPRALQVAVAALQAFQLVGMPEGRIIMAQAVTYLATAPKSNASYAGIDAALAEVRKSGALPVPLHIRNAPTRLMKDLGYHAGYKYAHDYEGGHVSQEYLPEQLRGKTFYAPRGHGYEKTIKERMEYLRTLQERNKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X50</accession>
    <name>Q39X50_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidylprolyl cis-trans isomerase, PpiC-type</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0932</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513962.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0932"/>
    <dbReference type="EnsemblBacteria" id="ABB31174">
        <property type="protein sequence ID" value="ABB31174"/>
        <property type="gene ID" value="Gmet_0932"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0932"/>
    <dbReference type="eggNOG" id="COG0760">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034646_5_3_7"/>
    <dbReference type="OMA" id="MKTIICL"/>
    <dbReference type="OrthoDB" id="1838755at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023058">
        <property type="entry name" value="PPIase_PpiC_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027304">
        <property type="entry name" value="Trigger_fact/SurA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109998">
        <property type="entry name" value="SSF109998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01096">
        <property type="entry name" value="PPIC_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="2">
        <location>
            <begin position="183"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="330" mass="37078" checksum="A734F2B124151A2C" modified="2005-11-22" version="1">MRLNRSLTFGLFLLGVMFTLHLLQTPVSADEVNKTGKVVARVNGVPIYENALQSHLAALANKGRASGFARDPAKMNDYQKKKALYSLIDAELLRQASNQQQVTDLDAKVSKRLQEVKGKFPDEEAFLKNLQARGKTLDIFVAELRDGIRYDEYLTSKKVIGVPVPDEEIQKFYRDNPTSFSVPEQIKVRHILIEPDGSTAEAVAKAEKKAGEIRNRVVRDKDFAAVAKEVSACSTASSGGDLGYVSRGTMPAEFDKVAFSLKLNEVSEPVRTKFGFHIMEVLDKKPVTVRPYSEVREFISRYLQRFDDEKRLNAHTLELRKKATIEVLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X63</accession>
    <name>Q39X63_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0919</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365745.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0919"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31161">
        <property type="protein sequence ID" value="ABB31161"/>
        <property type="gene ID" value="Gmet_0919"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0919"/>
    <dbReference type="eggNOG" id="COG1216">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823260_0_0_7"/>
    <dbReference type="OMA" id="VPVWNRP"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glyco_trans_2-like" evidence="1">
        <location>
            <begin position="7"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="355" mass="39323" checksum="6FD966DD230B2C20" modified="2005-11-22" version="1">MTPFTVDILIPIWNRPVETRNCLVTLMETTPSARLILIDNGSDRETERLLEEFSEILGERALFLKTSANQGFVRAVNRSLAQVEAPYAVVMQNTTLVTRGWLEPMVELADSRPDAGIIVPRLELEDGQGRRPKAAPPAGPVTEVSHGSFAASMVRRELVERQGGFDEELDGGPWCLRDYSRRAFRNGFLTLALDGAVVTYAEEVPLGSVARREETVRRSAETCRARWGREDAFCIYFPKDAEPEAVHGKLDVILRGARMGQCFTLILHPGLHKSLMETGHAPLHSNIALAPLPRFFATGEIRKIIGKLASVRGDTVTVAGVDGLSIPGVEGARSFSWLADEIRRRHESLYRPESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X98</accession>
    <name>Q39X98_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UDP-4-amino-4-deoxy-L-arabinose formyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">arnG</name>
        <name evidence="3" type="ordered locus">Gmet_0884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513031.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0884"/>
    <dbReference type="EnsemblBacteria" id="ABB31126">
        <property type="protein sequence ID" value="ABB31126"/>
        <property type="gene ID" value="Gmet_0884"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0884"/>
    <dbReference type="eggNOG" id="COG0223">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_033347_2_0_7"/>
    <dbReference type="OMA" id="IIVANNW"/>
    <dbReference type="OrthoDB" id="2009156at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016742">
        <property type="term" value="F:hydroxymethyl-, formyl- and related transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009058">
        <property type="term" value="P:biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005793">
        <property type="entry name" value="Formyl_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011034">
        <property type="entry name" value="Formyl_transferase-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02911">
        <property type="entry name" value="Formyl_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50486">
        <property type="entry name" value="SSF50486"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="SSF53328"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Formyl_trans_N" evidence="1">
        <location>
            <begin position="30"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Formyl_trans_C" evidence="2">
        <location>
            <begin position="210"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="311" mass="33962" checksum="36D1250A30EF3795" modified="2005-11-22" version="1">MASSSGRGTRVVVCAYHNVGFRCLEELLKQGADVRLVFTHEDSPTEEIWFQSVRELAQRHGIPYLTSDINEPANVAKVREIAPDFLFSFYYRNMITPEVLDIPRKGALNLHGSYLPKYRGRVPVNWAVINGETETGATLHHMVEKPDAGDIVDREKVPIAFTDTSFDVFTKVTDAAVTVISRSYPLLVAGTAPRIPMNLVEGNYCGGRRPADGLIDWTKSAVQIYNLIRGVTHPYPGAFTYLDGKKILVWSARPLPGSAEPGVVVTEDPLVVGTGEGLLEITSLQLEGGDEVAAGSFSAIVHPAGKRFANP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XG4</accession>
    <name>Q39XG4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">McbC-like oxidoreductase for polypeptide thioester cyclization</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0818</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514405.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0818"/>
    <dbReference type="EnsemblBacteria" id="ABB31060">
        <property type="protein sequence ID" value="ABB31060"/>
        <property type="gene ID" value="Gmet_0818"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0818"/>
    <dbReference type="eggNOG" id="COG0778">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059362_1_0_7"/>
    <dbReference type="OMA" id="GHMGQNI"/>
    <dbReference type="OrthoDB" id="1267141at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.109.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029479">
        <property type="entry name" value="Nitroreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000415">
        <property type="entry name" value="Nitroreductase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00881">
        <property type="entry name" value="Nitroreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55469">
        <property type="entry name" value="SSF55469"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223250" evidence="2">
        <location>
            <begin position="26"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Nitroreductase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB31060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="282" mass="30294" checksum="943D60ED6F1A2F40" modified="2005-11-22" version="1">MTNVSRMVAGGALCLFLAIPLATFADGAKVTQLEPPRKEGGVPLMDALRERKSVREFSGEALSPRQLSDLLWAAFGINRPEKGGRTAPSAMNRQEIDVYVATSDGLYLYDARGHRLIQEGTRDIRALTGRQPFVAEAPVNLIYVADYGQMGEASLEEKAFYAAADAGAISQNVYLFCASEGLATVARASIDSPALAKAMGLRNEQRIVLAQSVGVPKVKAGVTKPSKHLTPPEQIWSTPARLADPPTSGAPEDAVTLPKKSSEHPRNPLGQPKLTIEKPTEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XG6</accession>
    <name>Q39XG6_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Pyruvate carboxylase</fullName>
            <ecNumber evidence="2 6">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pyc</name>
        <name evidence="14" type="ordered locus">Gmet_0816</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + hydrogencarbonate + pyruvate = ADP + H(+) + oxaloacetate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="2 6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514403.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0816"/>
    <dbReference type="EnsemblBacteria" id="ABB31058">
        <property type="protein sequence ID" value="ABB31058"/>
        <property type="gene ID" value="Gmet_0816"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0816"/>
    <dbReference type="eggNOG" id="COG1038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000395_0_1_7"/>
    <dbReference type="OMA" id="YAIQSRV"/>
    <dbReference type="OrthoDB" id="361205at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006090">
        <property type="term" value="P:pyruvate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CbamoylP_synth_lsu-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="SSF51230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="SSF51246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="SSF52440"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="3 6" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="5"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="125"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="13">
        <location>
            <begin position="536"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="1073"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="545"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="617"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="9">
        <location>
            <position position="714"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="743"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="745"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="878"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB31058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1148" mass="127097" checksum="5DE57E5806A94BE4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-06-12" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XL1</accession>
    <name>NQOR_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)H dehydrogenase (quinone)</fullName>
            <ecNumber evidence="1">1.6.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName>Flavoprotein WrbA</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">NAD(P)H:quinone oxidoreductase</fullName>
            <shortName evidence="1">NQO</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ordered locus">Gmet_0771</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + H(+) + NADH = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a quinone + H(+) + NADPH = a quinol + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:46164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="1">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513516.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XL1"/>
    <dbReference type="SMR" id="Q39XL1"/>
    <dbReference type="STRING" id="269799.Gmet_0771"/>
    <dbReference type="EnsemblBacteria" id="ABB31013">
        <property type="protein sequence ID" value="ABB31013"/>
        <property type="gene ID" value="Gmet_0771"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0771"/>
    <dbReference type="eggNOG" id="COG0655">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_051402_0_2_7"/>
    <dbReference type="OMA" id="KFADGNP"/>
    <dbReference type="OrthoDB" id="796211at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008753">
        <property type="term" value="F:NADPH dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01017">
        <property type="entry name" value="NQOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005025">
        <property type="entry name" value="FMN_Rdtase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037513">
        <property type="entry name" value="NQO"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03358">
        <property type="entry name" value="FMN_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="SSF52218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0285">Flavoprotein</keyword>
    <keyword id="KW-0288">FMN</keyword>
    <keyword id="KW-0520">NAD</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000291016" description="NAD(P)H dehydrogenase (quinone)">
        <location>
            <begin position="1"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="1">
        <location>
            <begin position="3"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="11"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="82"/>
            <end position="84"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="102"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="117"/>
            <end position="123"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01017"/>
        </source>
    </evidence>
    <sequence length="203" mass="21538" checksum="7CA99102A7D9CDB0" modified="2005-11-22" version="1">MKVLIPFYSMYGHIYRMAEAVAEGVREVSGAEAVLRRVPETLPTDVLQKMGAVEPQKAFAHIPVCTVDELAAADAIIFGTPTRFGNMCGQMRQFLDATGGLWVKGGLVGKAGGVFTSSATQHGGQESTILTFHTFLLHQGMVLVGLPYAFAGQMRIDEITGGSPYGASTIAGGQGERLPSENELAGARYQGKYIAEIAAKLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XM4</accession>
    <name>Q39XM4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0758</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513503.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0758"/>
    <dbReference type="EnsemblBacteria" id="ABB31000">
        <property type="protein sequence ID" value="ABB31000"/>
        <property type="gene ID" value="Gmet_0758"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0758"/>
    <dbReference type="eggNOG" id="ENOG5034BUY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1336466_0_0_7"/>
    <dbReference type="OMA" id="FWVFPFR"/>
    <dbReference type="OrthoDB" id="1694163at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="217" mass="23507" checksum="199BB2C5ACF446AC" modified="2005-11-22" version="1">MADRHDLRVIPLRCPACGATLEAGGEDVIYPCKPCGSYRELVGEELVQREIVHVAGPDLDAPPAARREMPRLPFWVFPFRAVTVGGEVATLREYLALAGSVSPLSPGRGEKSPLVFVPAFAAKSASLLRAGRLLTLRSPAFGRSAGVPSRIAPIVFREADARALTEAVVLATVATERRVNQRFLDSFAVRCGAGRLLSIPFDDREGRLHQPDLDLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XS0</accession>
    <name>Q39XS0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methyl-accepting chemotaxis sensory transducer, class 40H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">mcp40H-4</name>
        <name evidence="6" type="ordered locus">Gmet_0712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyl-accepting chemotaxis (MCP) protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514617.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0712"/>
    <dbReference type="EnsemblBacteria" id="ABB30954">
        <property type="protein sequence ID" value="ABB30954"/>
        <property type="gene ID" value="Gmet_0712"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0712"/>
    <dbReference type="eggNOG" id="COG0840">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_107_27_7"/>
    <dbReference type="OMA" id="NIANGDW"/>
    <dbReference type="OrthoDB" id="429006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004888">
        <property type="term" value="F:transmembrane signaling receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004090">
        <property type="entry name" value="Chemotax_Me-accpt_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024478">
        <property type="entry name" value="HlyB_4HB_MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004089">
        <property type="entry name" value="MCPsignal_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12729">
        <property type="entry name" value="4HB_MCP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00015">
        <property type="entry name" value="MCPsignal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00260">
        <property type="entry name" value="CHEMTRNSDUCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00283">
        <property type="entry name" value="MA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50111">
        <property type="entry name" value="CHEMOTAXIS_TRANSDUC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0807">Transducer</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="5">
        <location>
            <begin position="219"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Methyl-accepting transducer" evidence="4">
        <location>
            <begin position="276"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="550" mass="57469" checksum="42438ECD1BEAF059" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XU2</accession>
    <name>Q39XU2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Undecaprenyl diphosphate phosphatase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514081.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0690"/>
    <dbReference type="EnsemblBacteria" id="ABB30932">
        <property type="protein sequence ID" value="ABB30932"/>
        <property type="gene ID" value="Gmet_0690"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0690"/>
    <dbReference type="eggNOG" id="COG0671">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072573_8_2_7"/>
    <dbReference type="OMA" id="IWVGHHY"/>
    <dbReference type="OrthoDB" id="1930882at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03385">
        <property type="entry name" value="PAP2_BcrC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxi_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="P_Acid_Pase_2/haloperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033879">
        <property type="entry name" value="UPP_Pase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="SSF48317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="acidPPc" evidence="2">
        <location>
            <begin position="51"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="198" mass="22179" checksum="9DB181639CF224B6" modified="2005-11-22" version="1">MEALNHRLFFLINAPAHPDALMVSFARGLADELIWLVPLLLIYGWLWGNEQRRIAMLEATVAGLAGLLANQVIALVWPHPRPFMVNMGHTFLRHVADSSFPSDHLTLIWSVSFCLIMRKHFRPAGIAVALAGLPVAWARIYLGVHFPLDMVGAALVAVMSAWLVLRGERLLIDVCYRPMFAAYHLLAKPLIRGGWLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XV0</accession>
    <name>Q39XV0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, GNAT family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514073.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0682"/>
    <dbReference type="EnsemblBacteria" id="ABB30924">
        <property type="protein sequence ID" value="ABB30924"/>
        <property type="gene ID" value="Gmet_0682"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0682"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054109_0_0_7"/>
    <dbReference type="OMA" id="WEEGTQI"/>
    <dbReference type="OrthoDB" id="1526822at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041496">
        <property type="entry name" value="YitH_GNAT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18014">
        <property type="entry name" value="Acetyltransf_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="269" mass="28595" checksum="AC4BEA9154FFFA78" modified="2005-11-22" version="1">MRIRPFYPDDVSLFLALAAAEGWISDPWEFAFILESFPCGCLAVEENGRPVAFATAVRYGASGWIGNLIVAEEYRGRGYGTLLMGRAMDQLLDSGARTVWLTASAQGRPLYEKMGFREMDGVVRWCGTATGGTQWHDDPVAPDELVPLDRAGWGDDRRCVLSAVAARGIVLRENGGFLVTQPCGSGFQLGPWAAEGRGVAGELLGRALSRLQGGAQVLLDVPVRNGAAASVLAHAGFAACGRTVLMCVGDEPAYKPEKIFALATLGSVG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-02" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XZ7</accession>
    <name>RS17_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsQ</name>
        <name type="ordered locus">Gmet_0635</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514245.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39XZ7"/>
    <dbReference type="SMR" id="Q39XZ7"/>
    <dbReference type="STRING" id="269799.Gmet_0635"/>
    <dbReference type="EnsemblBacteria" id="ABB30877">
        <property type="protein sequence ID" value="ABB30877"/>
        <property type="gene ID" value="Gmet_0635"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0635"/>
    <dbReference type="eggNOG" id="COG0186">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073626_1_2_7"/>
    <dbReference type="OMA" id="HPMYGKF"/>
    <dbReference type="OrthoDB" id="2035880at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01345_B">
        <property type="entry name" value="Ribosomal_S17_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019984">
        <property type="entry name" value="Ribosomal_S17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_S17/S11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_S17_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="PTHR10744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03635">
        <property type="entry name" value="uS17_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000233481" description="30S ribosomal protein S17">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01345"/>
        </source>
    </evidence>
    <sequence length="85" mass="10054" checksum="CC3F659F2D5A563C" modified="2005-11-22" version="1">MSQRGNRKTQVGIVVSDKMDKTVVVQVSHLVKHPVYNKYIKRSVKYKAHDEENSCKSGDRVQIVETRPLSKDKRWRVRQIIDRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y47</accession>
    <name>Q39Y47_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512282.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0584"/>
    <dbReference type="EnsemblBacteria" id="ABB30827">
        <property type="protein sequence ID" value="ABB30827"/>
        <property type="gene ID" value="Gmet_0584"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0584"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011615_5_0_7"/>
    <dbReference type="OrthoDB" id="1251981at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="546" mass="60206" checksum="D31A66374557AC73" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y55</accession>
    <name>Q39Y55_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0576</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365688.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0576"/>
    <dbReference type="EnsemblBacteria" id="ABB30819">
        <property type="protein sequence ID" value="ABB30819"/>
        <property type="gene ID" value="Gmet_0576"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0576"/>
    <dbReference type="eggNOG" id="COG4386">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4733">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_262794_0_0_7"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="4">
        <location>
            <begin position="847"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1284" mass="134512" checksum="6B745402246D4289" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YC6</accession>
    <name>Q39YC6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512201.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0505"/>
    <dbReference type="EnsemblBacteria" id="ABB30748">
        <property type="protein sequence ID" value="ABB30748"/>
        <property type="gene ID" value="Gmet_0505"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0505"/>
    <dbReference type="eggNOG" id="ENOG50300QI">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1862327_0_0_7"/>
    <dbReference type="OMA" id="RMLRWQE"/>
    <dbReference type="OrthoDB" id="1865786at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223626" evidence="1">
        <location>
            <begin position="23"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="136" mass="15994" checksum="2C11BCDC4F26F2A2" modified="2005-11-22" version="1">MRIQRVASFFLMLLFLAGCRNTYLVAQRFEDSSREYDRLVRWQEHENACMSFAASTVADECLARAKAAKGVSMADYRVKRVDMDPEKGTATVRVEIDYYILPSTRLKTLEDVQQWRYEEIDGKERWRIVTPLPEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YN1</accession>
    <name>Q39YN1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">zf-RING_7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365662.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0400"/>
    <dbReference type="EnsemblBacteria" id="ABB30643">
        <property type="protein sequence ID" value="ABB30643"/>
        <property type="gene ID" value="Gmet_0400"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0400"/>
    <dbReference type="eggNOG" id="COG1579">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_073076_2_2_7"/>
    <dbReference type="OMA" id="EHCGRIL"/>
    <dbReference type="OrthoDB" id="833439at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003743">
        <property type="entry name" value="Zf-RING_7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02591">
        <property type="entry name" value="zf-RING_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="zf-RING_7" evidence="2">
        <location>
            <begin position="199"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="237" mass="26760" checksum="1D5AD90B5BDFE2BE" modified="2005-11-22" version="1">MRKNLFMLEELQELDLKIDGRQGGRQTLLDQMVELDQQVEETRLAVDAKRGELALLEEEKEGLEANLVTEDENIARSEVRQKEIKTQKEYQAVVKEITAARKLKAELEEQILQKSAQAEELTADIAAREADLASLEENMASRKAEIQEGLDRIDRELAADAAAKETTVKAIPASLVKRYLALRERRQGIAIVEARAGNCSGCNMNLPPQLYNSLFRGDDLVLCPHCQRMLFLRQDAQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YP3</accession>
    <name>HIS4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase</fullName>
            <ecNumber evidence="1">5.3.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisA</name>
        <name type="ordered locus">Gmet_0388</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:15469"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="5.3.1.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HisA/HisF family.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.16" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512360.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YP3"/>
    <dbReference type="SMR" id="Q39YP3"/>
    <dbReference type="STRING" id="269799.Gmet_0388"/>
    <dbReference type="EnsemblBacteria" id="ABB30631">
        <property type="protein sequence ID" value="ABB30631"/>
        <property type="gene ID" value="Gmet_0388"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0388"/>
    <dbReference type="eggNOG" id="COG0106">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_1_1_7"/>
    <dbReference type="OMA" id="EWLHLVD"/>
    <dbReference type="OrthoDB" id="794219at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00009"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003949">
        <property type="term" value="F:1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04732">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01014">
        <property type="entry name" value="HisA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006063">
        <property type="entry name" value="HisA_bact_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044524">
        <property type="entry name" value="Isoase_HisA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023016">
        <property type="entry name" value="Isoase_HisA-like_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43090">
        <property type="entry name" value="PTHR43090"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00007">
        <property type="entry name" value="TIGR00007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0413">Isomerase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000229058" description="1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01014"/>
        </source>
    </evidence>
    <sequence length="244" mass="25421" checksum="73C84D71F8213E86" modified="2005-11-22" version="1">MIVIPAIDLKEGKCVRLEQGLMEKDTVFCDNPADQARAWERQGAELLHIVDLDGAFAGEPKNRASIEAIVKAIAIPTQLGGGIRDIPTIEAYLSLGIGRVILGTAAQRNPELVEEACRLFPGRIVVGIDAKDGMVAVQGWAEVTGVTAVDLAKRFEGYGVAAIIYTDIARDGMMQGPNIAATRALAEAISIPVIASGGVSSLKDIENLMTIEASGIAGAITGKAVYTGAINLAEAVALTKRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YS4</accession>
    <name>Q39YS4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512329.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0357"/>
    <dbReference type="EnsemblBacteria" id="ABB30600">
        <property type="protein sequence ID" value="ABB30600"/>
        <property type="gene ID" value="Gmet_0357"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0357"/>
    <dbReference type="eggNOG" id="COG3784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1254970_0_0_7"/>
    <dbReference type="OMA" id="NDRWVQK"/>
    <dbReference type="OrthoDB" id="1714881at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008309">
        <property type="entry name" value="UCP025560"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07027">
        <property type="entry name" value="DUF1318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="219" mass="23749" checksum="3A9926ABBE5BC955" modified="2005-11-22" version="1">MKRTIMKALLAGLFGMLAACAIITVNVYFPEKAVKEAYKSLDEMLLKPGEEKPAPDGQKPAEEKPAPGPQSKLLKGFSSFALVGEAFAADNYADQLAIEISGMPEVLKAYDEMKARLPQLDLLRDQGVVGETNQGLVTIRDKGKATPQDEALVKAEVANRKTVITAMARAILKLNKQPESKATIGQVLPKAAATYADAKREAAKPGWWTQLANGRWVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YY1</accession>
    <name>Q39YY1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PAS domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514009.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0298"/>
    <dbReference type="EnsemblBacteria" id="ABB30543">
        <property type="protein sequence ID" value="ABB30543"/>
        <property type="gene ID" value="Gmet_0298"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0298"/>
    <dbReference type="eggNOG" id="COG5000">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_144643_0_0_7"/>
    <dbReference type="OMA" id="EFTIQML"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="1">
        <location>
            <begin position="6"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="149" mass="16532" checksum="E7F6FA07395A58BC" modified="2005-11-22" version="1">MPDTTNDKLLRLIAEGVPDAVIFADREGIVRIWSPGAERMFGFTAAEAVGQSLDLIIPENLRARHWEGYRRVMETGETHYGTKLLSAPALCSAGGRISTEFSMALVRDCEGAMAGSGAIIRDVTERWQKEKAMKERLAELERHEAERNG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z72</accession>
    <name>ASSY_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Argininosuccinate synthase</fullName>
            <ecNumber evidence="1">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">argG</name>
        <name type="ordered locus">Gmet_0206</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-aspartate + L-citrulline = 2-(N(omega)-L-arginino)succinate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10932"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.4.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512795.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Z72"/>
    <dbReference type="SMR" id="Q39Z72"/>
    <dbReference type="STRING" id="269799.Gmet_0206"/>
    <dbReference type="EnsemblBacteria" id="ABB30452">
        <property type="protein sequence ID" value="ABB30452"/>
        <property type="gene ID" value="Gmet_0206"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0206"/>
    <dbReference type="eggNOG" id="COG0137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032784_4_2_7"/>
    <dbReference type="OMA" id="QCEVVTF"/>
    <dbReference type="OrthoDB" id="357142at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="Argininosuccinate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="PTHR11587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="SSF69864"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0055">Arginine biosynthesis</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000263928" description="Argininosuccinate synthase">
        <location>
            <begin position="1"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="14"/>
            <end position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>L-aspartate</name>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>L-citrulline</name>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00005"/>
        </source>
    </evidence>
    <sequence length="406" mass="45765" checksum="C90737ACB588EA90" modified="2005-11-22" version="1">MAKVHKDVKKIVLAYSGGLDTSIILKWLKNEYGCEVIAFSADLGQGDELAPIRDKAFATGADKVYIDDLKEEFVRDFVFPMFRANAIYEGHYLLGTSIARPLIAKRQMEIAKIEGADAVSHGATGKGNDQVRFELAYYHFDPAITVVVPWREWKLNSRQALVNYAKKNGIPIPVTKKRPWSSDRNMLHISFEGGILEDTWAEPPENMYVLTKAPEKAPNKPQFVEIEFKNGNAVAVDGEKMSPAQLLAHLNYIGGEHGIGRVDLLENRSVGMKSRGVYETPGGTILREAHSAVEQITMDREVMRIRDSLIPEYARQVYSGYWFSPEREMLQTLIDDSQKCVNGVARVKLYKGHCRTVGRKSETNSLFNLDFATFEKDQVFNQADATGFIKINSLRLRIRALMQGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z78</accession>
    <name>Q39Z78_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Regulatory protein RecX</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4 5" type="primary">recX</name>
        <name evidence="5" type="ordered locus">Gmet_0200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Modulates RecA activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RecX family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512789.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0200"/>
    <dbReference type="EnsemblBacteria" id="ABB30446">
        <property type="protein sequence ID" value="ABB30446"/>
        <property type="gene ID" value="Gmet_0200"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0200"/>
    <dbReference type="eggNOG" id="COG2137">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066607_3_3_7"/>
    <dbReference type="OrthoDB" id="2025178at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01114">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003783">
        <property type="entry name" value="Regulatory_RecX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33602">
        <property type="entry name" value="PTHR33602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02631">
        <property type="entry name" value="RecX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="155" mass="17645" checksum="AF4A61E54464176C" modified="2005-11-22" version="1">MGEERSGFSRALDILSRRDHSEAELALKLRRKGIDEREIASVVARLRELGYLNDRRLAERIAETAMAGGRMAGPRLSRELIRRGIPRELAAEALARATEGRDLRDDIREMLAGKFSSFDPREADLREKRRVVGWFQRRGYPLSAILDALRVSADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z90</accession>
    <name>Q39Z90_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonuclease Z-related hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512777.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0188"/>
    <dbReference type="EnsemblBacteria" id="ABB30434">
        <property type="protein sequence ID" value="ABB30434"/>
        <property type="gene ID" value="Gmet_0188"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0188"/>
    <dbReference type="eggNOG" id="COG1234">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_823444_0_0_7"/>
    <dbReference type="OMA" id="MDHFMGM"/>
    <dbReference type="OrthoDB" id="1712770at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="34"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="361" mass="40275" checksum="57990B756AA38151" modified="2005-11-22" version="1">MKRLPFRYLEPTFCAGLLDDPVLLVNVRPLGRAILVDCGQLHHLAKRVLKSLDAIFITHAHMDHFMGFDTLVRHIHVSPRTVQLFGPAGIAGKVTAKLAGYDWNLTESYWCTFRVHEVHPDRIINFTFPGAQGFPCLPEGETPRAGTEIYRNPLLTVDAAICDHNAIPTLAFRITERPSFWIDGGKIASEELVPGEWLRELKSRFYRGELDGRTITVPCRTAAGGVEERSVHGRELFEAIRRDQEPAGIGYLTDIGASAGNLATARRLLTGVTLLACECSFLAADRDKARTSHHLCTTDVSALARELRPGWLLPMHLSKSYNTKGHLIYDELALAPETRLIRLPEHLTPRPLLPTEFPKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="50" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZE6</accession>
    <name>Q39ZE6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0129</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514134.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0129"/>
    <dbReference type="EnsemblBacteria" id="ABB30378">
        <property type="protein sequence ID" value="ABB30378"/>
        <property type="gene ID" value="Gmet_0129"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0129"/>
    <dbReference type="HOGENOM" id="CLU_2355704_0_0_7"/>
    <dbReference type="OrthoDB" id="442163at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="96" mass="10504" checksum="E35C9DEDB310683E" modified="2005-11-22" version="1">MKGAHGRFCEVSQLLAGDARGGQLADDLLNACFDHVLPEDGGEGSMKTLAHLMVTLDRFNAHVRREGGEGLFVGSPEEVAAWAEELTRQIWENRPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZJ3</accession>
    <name>Q39ZJ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514781.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0082"/>
    <dbReference type="EnsemblBacteria" id="ABB30331">
        <property type="protein sequence ID" value="ABB30331"/>
        <property type="gene ID" value="Gmet_0082"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0082"/>
    <dbReference type="eggNOG" id="COG2114">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1233577_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="224" mass="26187" checksum="111629132F66E192" modified="2005-11-22" version="1">MTQESDMAQEVMAAVLVFDICSSTDILEDLHRTDNLQKWRNLLIGVKKFIVEQGDNFPFRLYNFTGDGWILLFDHNIDGEKLLPFIRKLCTTFKHLYEQKIHPVLETPPEIIGLTIGMDRGRLIKIRLNHRDEYVGRPLNVACRLQSAIKDRDKNPANKMLMTKNLYNSIKQDTIQWRFTEVERTLRNIAGSRRVSCMKLMSIEPQNVTKRILHPPLLQRKNRG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZJ9</accession>
    <name>GATC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C</fullName>
            <shortName evidence="1">Asp/Glu-ADT subunit C</shortName>
            <ecNumber evidence="1">6.3.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">gatC</name>
        <name type="ordered locus">Gmet_0076</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + L-glutamyl-tRNA(Gln) = ADP + H(+) + L-glutamate + L-glutaminyl-tRNA(Gln) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17521"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="Rhea" id="RHEA-COMP:9684"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-aspartyl-tRNA(Asn) + L-glutamine = ADP + 2 H(+) + L-asparaginyl-tRNA(Asn) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14513"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="Rhea" id="RHEA-COMP:9677"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterotrimer of A, B and C subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GatC family.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.-" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514200.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZJ9"/>
    <dbReference type="SMR" id="Q39ZJ9"/>
    <dbReference type="STRING" id="269799.Gmet_0076"/>
    <dbReference type="EnsemblBacteria" id="ABB30325">
        <property type="protein sequence ID" value="ABB30325"/>
        <property type="gene ID" value="Gmet_0076"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0076"/>
    <dbReference type="eggNOG" id="COG0721">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105899_6_1_7"/>
    <dbReference type="OMA" id="VTPMAMK"/>
    <dbReference type="OrthoDB" id="1780195at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050566">
        <property type="term" value="F:asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050567">
        <property type="term" value="F:glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00122">
        <property type="entry name" value="GatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003837">
        <property type="entry name" value="Asp/Glu-ADT_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036113">
        <property type="entry name" value="Asp/Glu-ADT_sf_sub_c"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15004">
        <property type="entry name" value="PTHR15004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02686">
        <property type="entry name" value="Glu-tRNAGln"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141000">
        <property type="entry name" value="SSF141000"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00135">
        <property type="entry name" value="gatC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000016123" description="Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00122"/>
        </source>
    </evidence>
    <sequence length="95" mass="10367" checksum="81E2D9FD39BDF2CC" modified="2005-11-22" version="1">MKITKAEVDAVALLARLELTPEETETFTGQMDAILAYVEKLNELDTSGIIPTSHAVPVENAFRDDAVRPSIGVENALANAPDRVEGFFRVPKVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZK9</accession>
    <name>Q39ZK9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">16S rRNA (cytosine(967)-C(5))-methyltransferase</fullName>
            <ecNumber evidence="5">2.1.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">16S rRNA m5C967 methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">rRNA (cytosine-C(5)-)-methyltransferase RsmB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">rsmB</name>
        <name evidence="14" type="ordered locus">Gmet_0066</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(967) in 16S rRNA + S-adenosyl-L-methionine = 5-methylcytidine(967) in 16S rRNA + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42748"/>
            <dbReference type="Rhea" id="RHEA-COMP:10219"/>
            <dbReference type="Rhea" id="RHEA-COMP:10220"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.176"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.176" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514190.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0066"/>
    <dbReference type="EnsemblBacteria" id="ABB30315">
        <property type="protein sequence ID" value="ABB30315"/>
        <property type="gene ID" value="Gmet_0066"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0066"/>
    <dbReference type="eggNOG" id="COG0144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0781">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005316_0_1_7"/>
    <dbReference type="OMA" id="RVNRQHH"/>
    <dbReference type="OrthoDB" id="1064993at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="Fmu/NOL1/Nop2p_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031341">
        <property type="entry name" value="Methyltr_RsmF_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB/NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035926">
        <property type="entry name" value="NusB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006027">
        <property type="entry name" value="NusB_RsmB_TIM44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004573">
        <property type="entry name" value="rRNA_ssu_MeTfrase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="PTHR22807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17125">
        <property type="entry name" value="Methyltr_RsmF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01029">
        <property type="entry name" value="NusB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48013">
        <property type="entry name" value="SSF48013"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00563">
        <property type="entry name" value="rsmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 12 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM_MT_RSMB_NOP" evidence="13">
        <location>
            <begin position="172"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="S-adenosyl-L-methionine binding" evidence="12">
        <location>
            <begin position="262"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="12">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="446" mass="49000" checksum="EC2CD4C0C9319380" modified="2005-11-22" version="1">MTRSNPRRTALDILLRVERDRAFAEQLLDRELSLGTLTGPDRGLLTELVYGVLRRQGTLDFLVDAFAASRSGKLERAILVILRLGLYQLFFLDRIPTSAAVNESVNLAKAVAPRAAGFVNAVLRRADRERDSLPWPDRGADPAAYIAVRHSHPRWLVEQWIEQLGIPEAEELAVAMAEQAPLTIRVNTLKTTREAFMEELAAAGITAEPTVWAPHGVRILSRTAVTTLPGFAEGLFTVQDESSQLAAFFLDPQPGERILDVCAAPGGKATYLAQLMENRGEVLACDISAKKLRLVAEAAARLGIGIIRTMAGDATKPGAGEPPFDRILLDAPCSGFGVIRRNPEGKWWKTPDDLARLAATQRNILAAVAPRLRPGGVLLYSTCSTMVAEDEDVVDDFLSRHEDFVLEDLNAISPDFPGQFTGRGHFRSWPHRHGMDGFFAARIRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZL9</accession>
    <name>Q39ZL9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hydrogen-dependent growth transcriptional repressor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hgtR</name>
        <name evidence="1" type="ordered locus">Gmet_0056</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514180.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30305">
        <property type="protein sequence ID" value="ABB30305"/>
        <property type="gene ID" value="Gmet_0056"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0056"/>
    <dbReference type="HOGENOM" id="CLU_207132_0_0_7"/>
    <dbReference type="OMA" id="NTRRIPD"/>
    <dbReference type="OrthoDB" id="2066134at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="63" mass="7489" checksum="8A77FBD35DECF1DC" modified="2005-11-22" version="1">MGRMRENPRYNVISMRISDEERDRLQQIMEATQKSVSDIMREAMEIFAVQLQKTEQPHHQKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="20" xmlns="http://uniprot.org/uniprot">
    <accession>J7LYC8</accession>
    <name>J7LYC8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3584"/>
    <dbReference type="EnsemblBacteria" id="AFR42798">
        <property type="protein sequence ID" value="AFR42798"/>
        <property type="gene ID" value="Gmet_3584"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3584"/>
    <dbReference type="HOGENOM" id="CLU_2316284_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="99" mass="11221" checksum="74DE4477A1F9F2BF" modified="2012-10-31" version="1">MNSNQCDTIIEESALGLKFQHNTTHTNSLSIYLLSRRRGTPASISRQSRWTADRSTMLHAQSNQGSATKTAPRLNADGAALRRERWSPPWNHYTNHCKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-06-02" version="19" xmlns="http://uniprot.org/uniprot">
    <accession>J7M077</accession>
    <name>J7M077_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="AFR42797">
        <property type="protein sequence ID" value="AFR42797"/>
        <property type="gene ID" value="Gmet_3583"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3583"/>
    <dbReference type="HOGENOM" id="CLU_2915953_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="61" mass="6680" checksum="F9937D5D8C2B805C" modified="2012-10-31" version="1">MSRNGADEKAASKLPRNSCQVPKKTRAMTKTTRKIETSLFTGGMILSPGSLRQQGRDVDVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="23" xmlns="http://uniprot.org/uniprot">
    <accession>J7M0A4</accession>
    <name>J7M0A4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366010.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3613"/>
    <dbReference type="EnsemblBacteria" id="AFR42832">
        <property type="protein sequence ID" value="AFR42832"/>
        <property type="gene ID" value="Gmet_3613"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3613"/>
    <dbReference type="HOGENOM" id="CLU_2934938_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="AFR42832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="60" mass="6867" checksum="FD5F94CF03BBDB95" modified="2012-10-31" version="1">MSDIKGLPRYNVISFRVTDEEMKAMRLLKKKRKSALARLIREALSATDFPVNMDAGNECH</sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2020-12-02" version="24" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEN2</accession>
    <name>J9JEN2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3603"/>
    <dbReference type="EnsemblBacteria" id="AFR42821">
        <property type="protein sequence ID" value="AFR42821"/>
        <property type="gene ID" value="Gmet_3603"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3603"/>
    <dbReference type="HOGENOM" id="CLU_2649310_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="76" mass="8525" checksum="74109376D56601ED" modified="2012-10-31" version="1">MSIMHPDVRNAPMMSAEKRSAFIEYPRLFNFRAVSKPFGSHYYSASRSSRVSVPPCGQSWLSDEPASTQEPAMSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PP9</accession>
    <name>Q39PP9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin, RHH family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_A3570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <geneLocation type="plasmid" evidence="2">
        <name>pGS-15</name>
    </geneLocation>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of plasmid of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
            <plasmid evidence="2">pGS-15</plasmid>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000149">
        <property type="protein sequence ID" value="ABB33775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514724.1">
        <property type="nucleotide sequence ID" value="NC_007515.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_A3570"/>
    <dbReference type="EnsemblBacteria" id="ABB33775">
        <property type="protein sequence ID" value="ABB33775"/>
        <property type="gene ID" value="Gmet_A3570"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_A3570"/>
    <dbReference type="eggNOG" id="COG4710">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_155311_6_1_7"/>
    <dbReference type="OMA" id="HYSECKV"/>
    <dbReference type="OrthoDB" id="2086657at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Plasmid pGS-15"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046257">
        <property type="entry name" value="DUF6290"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010985">
        <property type="entry name" value="Ribbon_hlx_hlx"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19807">
        <property type="entry name" value="DUF6290"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47598">
        <property type="entry name" value="SSF47598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0614">Plasmid</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="74" mass="8608" checksum="6E0D050777C13D81" modified="2005-11-22" version="1">MLAIRLPEEIETRLDSLAKATGRSKSYYVREALVEYLDDLEDIYLAEKRLEDIRAGRTKTIPLEEVMKEYGLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PT2</accession>
    <name>Q39PT2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Biopolymer transport membrane proton channel, TolQ-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_3537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the exbB/tolQ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513693.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3537"/>
    <dbReference type="EnsemblBacteria" id="ABB33742">
        <property type="protein sequence ID" value="ABB33742"/>
        <property type="gene ID" value="Gmet_3537"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3537"/>
    <dbReference type="eggNOG" id="COG0811">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_053325_2_2_7"/>
    <dbReference type="OMA" id="SWTYIFR"/>
    <dbReference type="OrthoDB" id="1796180at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043213">
        <property type="term" value="P:bacteriocin transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002898">
        <property type="entry name" value="MotA_ExbB_proton_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014163">
        <property type="entry name" value="Tol-Pal_TolQ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01618">
        <property type="entry name" value="MotA_ExbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02796">
        <property type="entry name" value="tolQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="MotA_ExbB" evidence="9">
        <location>
            <begin position="95"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB33742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="224" mass="24835" checksum="0ACDA1F35B48C109" modified="2005-11-22" version="1">MLHLAGTGLVVKLVLLILIFFSVVSWAIIFFKLLQVYRANSESERFLDFFWKTKRFDAVNSQLDRFTNSPLTVLFSEGYSELKRLVEKGDQKEELDVMSTELGGIENIARALRRATTSEITRLEKYVTFLATTGSTTPFIGLFGTVWGIMTAFKGIGETGSASLAVVAPGISEALIATAIGLVAAIPAVMAYNHFQYKIKVLIATMDNFSTEFLNIVQRTVTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PV4</accession>
    <name>Q39PV4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513671.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3515"/>
    <dbReference type="EnsemblBacteria" id="ABB33720">
        <property type="protein sequence ID" value="ABB33720"/>
        <property type="gene ID" value="Gmet_3515"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3515"/>
    <dbReference type="HOGENOM" id="CLU_190609_1_0_7"/>
    <dbReference type="OMA" id="GKISAFH"/>
    <dbReference type="OrthoDB" id="2044847at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="70" mass="8300" checksum="73AB3022737CE4BB" modified="2005-11-22" version="1">MLIRVRYQDNTYDMVKAWRLEEYIATGKISAFHRGNEWVTVSRDQVRHSGDTSYGGPERRRRENNLSRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PW3</accession>
    <name>Q39PW3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3506</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33711.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366200.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3506"/>
    <dbReference type="EnsemblBacteria" id="ABB33711">
        <property type="protein sequence ID" value="ABB33711"/>
        <property type="gene ID" value="Gmet_3506"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3506"/>
    <dbReference type="HOGENOM" id="CLU_165407_0_0_7"/>
    <dbReference type="OMA" id="NAPPDVY"/>
    <dbReference type="OrthoDB" id="1983020at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33711.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="128" mass="13550" checksum="3AFA6DC550938215" modified="2012-10-31" version="2">MKAWQLRTGPAMFNKIIAVLLIMAVITIAGNGLCFAQDNDHCPQASCAKAGTVLKADCGDASPCCPDDGGDTEGHCHCCLSCPCHAPLNSQPPLISYSPLVISLSFLEHLNAPPDVYRSIFVPPQIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PW4</accession>
    <name>Q39PW4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Zinc-dependent membrane dipeptidase, M19 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_3505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513661.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3505"/>
    <dbReference type="DNASU" id="3739046"/>
    <dbReference type="EnsemblBacteria" id="ABB33710">
        <property type="protein sequence ID" value="ABB33710"/>
        <property type="gene ID" value="Gmet_3505"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3505"/>
    <dbReference type="eggNOG" id="COG2355">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031404_2_1_7"/>
    <dbReference type="OMA" id="KHIFHIA"/>
    <dbReference type="OrthoDB" id="1145595at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="PTHR10443"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="SSF51556"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="327" mass="34318" checksum="4C6EB12187C8D8B1" modified="2005-11-22" version="1">MSLHPADFIEKPPRFPVVDGHVDLVYDLMRRHPGIPFEQVADGQVTAQSLKKGGVWVLVAALYCADSHNGPASAAREMRRLHDYACRYLEWFALLRSPGEMAAALGGSGPPGIVFLVENADALLELDLDEVRRWGVRAVGLTHAGRNRLADGNGVTDPKGLTAAGKSLVRSIAGAGLILDVAHLAEPGFREVASLVTGPLISSHTGLRSFCDRPRNLSDPQVAEIARRGGVVGISAAPEMLVPGGTATLDDLFRQVDHVVQRHGPEAVGIGSDFGGFDDTAKGAEDHGGLPLLAERLLGAGYPAGAVGLIMGGNWCRIYGGIPGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q09</accession>
    <name>Q39Q09_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_3456</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513907.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3456"/>
    <dbReference type="EnsemblBacteria" id="ABB33665">
        <property type="protein sequence ID" value="ABB33665"/>
        <property type="gene ID" value="Gmet_3456"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3456"/>
    <dbReference type="eggNOG" id="COG0697">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2371">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042632_0_0_7"/>
    <dbReference type="OMA" id="EPHSHWH"/>
    <dbReference type="OrthoDB" id="1515911at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="3">
        <location>
            <begin position="155"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB33665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="346" mass="37135" checksum="279C8F5CF3E1686E" modified="2005-11-22" version="1">MYSGQFLAVISAALFGISPVLCKLVIGEMSPALLAGLLYLGSGIGLHILLLFQGKKSIEEVKRLSPKKRLALLGSILSGGVVAPLFLAYGIKFGTASEVSLLLNIETVATTLIAWFVFREHVGLGVWGGKALILLGSVFVILKNDGSLAFSFAGLLVLLACAFWGIDNNLTRDIEELPATVLASIKGFGAGAFNTLLALALSTGTATVPQVAGSLLIGAMSYGMSLVLFVEALRRIGSARTSTLFAIGPFVGTFLSVLILGERPPATYWVAASLMLAGIALLQREMHGHPHTHEELSHSHKHLHDEHHQHEHAEGEGTEPHDHPHLHEPLTHSHVHWPDIHHRHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q67</accession>
    <name>Q39Q67_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">4-oxobutanoate dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">gabD</name>
        <name evidence="7" type="ordered locus">Gmet_3395</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33607.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512621.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3395"/>
    <dbReference type="EnsemblBacteria" id="ABB33607">
        <property type="protein sequence ID" value="ABB33607"/>
        <property type="gene ID" value="Gmet_3395"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3395"/>
    <dbReference type="eggNOG" id="COG1012">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005391_5_1_7"/>
    <dbReference type="OMA" id="WHKLIEQ"/>
    <dbReference type="OrthoDB" id="384611at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009013">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="CACAO"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010102">
        <property type="entry name" value="Succ_semiAld_DH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="SSF53720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01780">
        <property type="entry name" value="SSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldedh" evidence="6">
        <location>
            <begin position="24"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33607.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="484" mass="51760" checksum="086C77CA8505B1B2" modified="2012-10-31" version="2">MMILKNSSLLKQQCYLDGHWCCADGGATIDVTNPATGEILGVVPKMGTQETRRAIEAANGALDGWKARTAKERSAILRRWFELIMENLEDLAVIMTAEQGKPLAESRGEIAYAASFIEWFAEEGKRIYGDTIPSYARDKRIVVIKEPIGVCAAITPWNFPAAMITRKAGPALAAGCTMVVKPATATPFSALALALIGEQAGIPAGVFSVITGSSKEIGDEMTGNPIVRKLTFTGSTEVGKQLTAQCAGTMKKVSMELGGNAPFIVFDDADLDAAVEGAIASKYRNTGQTCVCTNRILVQESVYEAFSAKLVAAVSKMTVGDGLKGEVQQGPLIDMTALEKVEEHIADAVAKGARVVLGGKRHALGGTFFEPTIITDVTPGMLVAREETFGPLAPLFKFSTDEEAIRMANDTEFGLASYFYSRDIRRVWKVSEALEYGMVGINTGLISSEVAPFGGVKESGVGREGSKYGIEEFVEVKYLCMGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q92</accession>
    <name>Q39Q92_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Type II secretion system protein J</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">gspJ</name>
        <name evidence="11" type="ordered locus">Gmet_3370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GSP J family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3370"/>
    <dbReference type="EnsemblBacteria" id="ABB33582">
        <property type="protein sequence ID" value="ABB33582"/>
        <property type="gene ID" value="Gmet_3370"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3370"/>
    <dbReference type="eggNOG" id="COG4795">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1303422_0_0_7"/>
    <dbReference type="OMA" id="LYGTYFS"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015627">
        <property type="term" value="C:type II protein secretion system complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015628">
        <property type="term" value="P:protein secretion by the type II secretion system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012902">
        <property type="entry name" value="N_methyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045584">
        <property type="entry name" value="Pilin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010055">
        <property type="entry name" value="T2SS_protein-GspJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07963">
        <property type="entry name" value="N_methyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11612">
        <property type="entry name" value="T2SSJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54523">
        <property type="entry name" value="SSF54523"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02532">
        <property type="entry name" value="IV_pilin_GFxxxE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00409">
        <property type="entry name" value="PROKAR_NTER_METHYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="211" mass="24113" checksum="6DC830A817089738" modified="2005-11-22" version="1">MSGTWPPRMTRTERGNGGFTLLEVLVAMLLLVIIAGALYSSYFTVLRARERAEEGGEQRRELRGTLDLLRRELDGAFYRTSDKRLRFVVNDRDIFGKPASTLELVTVAPPSAEERPASDLVLVKYEVKEKEKRLSLNREATDLFGSMKPIPYPQMDEIEGFLVECYDSGKWVRTWNTELSPKLPERVRIILTVRDGENTADYSVTAKPRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QD4</accession>
    <name>Q39QD4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6016 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3327</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512551.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3327"/>
    <dbReference type="EnsemblBacteria" id="ABB33540">
        <property type="protein sequence ID" value="ABB33540"/>
        <property type="gene ID" value="Gmet_3327"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3327"/>
    <dbReference type="eggNOG" id="COG0662">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_121835_0_0_7"/>
    <dbReference type="OMA" id="AMEPGTY"/>
    <dbReference type="OrthoDB" id="1928636at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027565">
        <property type="entry name" value="Cupin_WbuC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046058">
        <property type="entry name" value="Cupin_WbuC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19480">
        <property type="entry name" value="DUF6016"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04366">
        <property type="entry name" value="cupin_WbuC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6016" evidence="1">
        <location>
            <begin position="5"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="154" mass="16541" checksum="8D52AFF6FC1E8A0D" modified="2005-11-22" version="1">MKIITRELLDQVTGEARGSARLRKNHNLHPSDDFCCHRLLNAMEPGSYIQPHRHLDPNKDESMVILRGRLGVVSFDGAGAVTGTRLLQPGDAVAVDIPHGEFHTVVSLEPGTVFFEAKAGPYLPLAGEEKASWAPAEGDGGAGTYHASLVALFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QF7</accession>
    <name>Q39QF7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Succinyl:benzoate coenzyme A transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512528.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3304"/>
    <dbReference type="EnsemblBacteria" id="ABB33517">
        <property type="protein sequence ID" value="ABB33517"/>
        <property type="gene ID" value="Gmet_3304"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3304"/>
    <dbReference type="eggNOG" id="COG0427">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030703_1_0_7"/>
    <dbReference type="OMA" id="EKMGIWR"/>
    <dbReference type="OrthoDB" id="319106at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="SSF100950"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AcetylCoA_hyd_C" evidence="2">
        <location>
            <begin position="278"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="437" mass="47911" checksum="7764ADB58842ED26" modified="2005-11-22" version="1">MESVKNAKRSYEKEYRQKVCSPVEAAAVVKSGDCLCFPISVGEPTLFVRALAARRHELEGVVINQQHHLCPDYFTEDSAPHIKVNAWFTSHVSREAVQKGWADFVPNYFHEVPRLLRDYWPVDVAGTVVSPMDEHGYFTCSLSVAYTMEAIKKAKKVVVQVNPQAPRTHGNCHIHISEVDHIIECDEPLASLTIPPITPVEEAIGGYISELVEDGSCLQLGWGGIPNSVCKALLHKKDLGIHTELLSDGMVDLMLSGAVNNSRKQTHTGKTVATFALGTSRLYEFMNENPRIEMHPVDYVNYPHNIGKNDNVVSINATLEVDLLGQCCSESFGHLQYSGTGGQADFVRGSNISNGGKGFITTASTAKNGTISRIVPTLAPGASVTTGKNDVDYVVTEFGVAKLRGQTARQRAINLINIAHPDFRGELTEAARRMNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QV9</accession>
    <name>Q39QV9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycine dehydrogenase (aminomethyl-transferring)</fullName>
            <ecNumber evidence="2">1.4.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">gcvP2</name>
        <name evidence="5" type="ordered locus">Gmet_3152</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(R)-N(6)-lipoyl-L-lysyl-[glycine-cleavage complex H protein] + glycine + H(+) = (R)-N(6)-(S(8)-aminomethyldihydrolipoyl)-L-lysyl-[glycine-cleavage complex H protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:24304"/>
            <dbReference type="Rhea" id="RHEA-COMP:10494"/>
            <dbReference type="Rhea" id="RHEA-COMP:10495"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="1.4.4.2"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="1.4.4.2" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513868.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3152"/>
    <dbReference type="EnsemblBacteria" id="ABB33365">
        <property type="protein sequence ID" value="ABB33365"/>
        <property type="gene ID" value="Gmet_3152"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3152"/>
    <dbReference type="eggNOG" id="COG1003">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004620_5_0_7"/>
    <dbReference type="OMA" id="MHINLHK"/>
    <dbReference type="OrthoDB" id="70707at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004375">
        <property type="term" value="F:glycine dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006546">
        <property type="term" value="P:glycine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020581">
        <property type="entry name" value="GDC_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11773">
        <property type="entry name" value="PTHR11773"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02347">
        <property type="entry name" value="GDC-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00033655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="481" mass="52287" checksum="8BA965627F4983BB" modified="2005-11-22" version="1">MQLIYEKSVPGRRGVRLPASDVPAAPELPAALRRKEPAALPEASELDVVRHFTGLSRRNFSVDTNFYPLGSCTMKYNAKVLEEAARLFAPYHPMVPLLPHGSSFSQGCLGLAYELGAALAEITGMDEVTTQPLAGAHGEMTGIMLIAAYHEAKGNKKKYVVVPDSSHGTNPASATMVGYEIITVPTAPYGDMDLDRFREVMTDEVAAVMMTCPNTLGLFNPHIQEICDIAHDHDALMYYDGANLNAILGKVRPGDVGFDVIHLNLHKTFGTPHGGGGPGSGPVGVKKQLVPFLPSPRIVKYDDGCYGVDAPAHGSIGRTSGFFGNFGVMAKAFAYITMVGREGLIQVSEQAVLNANYVMHRLKDVYDLPYDQTCMHECVFSAARQVKSGVHAIDIAKFLIDRGYHPPTVYFPLIVKEAIMIEPTETESKETLDAFIAVMREAAELAESDPAAFAEMPRTMPVTRLDETKAAREQNVCYFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QW0</accession>
    <name>Q39QW0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoate--protein ligase A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">lplA</name>
        <name evidence="2" type="ordered locus">Gmet_3151</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513867.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3151"/>
    <dbReference type="EnsemblBacteria" id="ABB33364">
        <property type="protein sequence ID" value="ABB33364"/>
        <property type="gene ID" value="Gmet_3151"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3151"/>
    <dbReference type="eggNOG" id="COG0095">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_022986_5_0_7"/>
    <dbReference type="OMA" id="YAYLDDW"/>
    <dbReference type="OrthoDB" id="871298at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="1">
        <location>
            <begin position="43"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="280" mass="29912" checksum="F7ABF45E766999C5" modified="2005-11-22" version="1">MSATLAADGSPNLTRWRLVDTGPLDGPANMAVDEALLLHFDPAASLPVLRLYGWEPPAFSVGRFQRAEDALHLERCAAAGIPVVRRITGGGVIYHAAELTYAVVCAPRHISDAQGVKESFRALTGFLIRFYGTLGFEASWAVDSQPPGKRLGVRTPLCFAGQEEYDIVSGGRKIGGNAQRRLKDVIFQHGSVPLRCALAEALPFFRQPPAGLLEGAASLAQLGVTADSAWLRERLVAAFAESLGVDLVLAVLTAEEEATAARLGAERYGKAAWNLHGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QY6</accession>
    <name>Q39QY6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514299.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3124"/>
    <dbReference type="EnsemblBacteria" id="ABB33338">
        <property type="protein sequence ID" value="ABB33338"/>
        <property type="gene ID" value="Gmet_3124"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3124"/>
    <dbReference type="eggNOG" id="ENOG5032YCZ">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_190060_0_1_7"/>
    <dbReference type="OMA" id="QNWLWFT"/>
    <dbReference type="OrthoDB" id="2045084at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021309">
        <property type="entry name" value="DUF2892"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11127">
        <property type="entry name" value="DUF2892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="70" mass="8122" checksum="2B8A79862EBC93AF" modified="2005-11-22" version="1">MYIDRMLRIIAGSFILISLLLANYHSINWLWFTAFVGLNLLQSGFTNWCPMITILEKLGVPRFPAECCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R04</accession>
    <name>Q39R04_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Flagellar hook-length control protein FliK</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">fliK</name>
        <name evidence="3" type="ordered locus">Gmet_3106</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514281.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3106"/>
    <dbReference type="EnsemblBacteria" id="ABB33320">
        <property type="protein sequence ID" value="ABB33320"/>
        <property type="gene ID" value="Gmet_3106"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3106"/>
    <dbReference type="eggNOG" id="COG3144">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_569570_0_0_7"/>
    <dbReference type="OMA" id="ETESNMA"/>
    <dbReference type="OrthoDB" id="1909634at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021136">
        <property type="entry name" value="Flagellar_hook_control-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038610">
        <property type="entry name" value="FliK-like_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02120">
        <property type="entry name" value="Flg_hook"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0966">Cell projection</keyword>
    <keyword evidence="3" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0282">Flagellum</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flg_hook" evidence="2">
        <location>
            <begin position="347"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="479" mass="49767" checksum="0A27249E2A7456B5" modified="2005-11-22" version="1">MSMEIMQMLQVIPQAVPTAGTAPEVPAGSAATPDLFASLMAGLLVEPPATTATAELPSLPAETAEPDDQNATAAKPDDITTAEAAMMSLASLVAPRTIVPQAAPVTETPVPTGTTIEASAAVAATQVMAAATATAPAALPSQPPLADAVIHQPELPRETTQAKTPITEAAPAAPAPQATPAPKAEEKNAVEVLKVNLEPTKTTEVELRTQASEPLPETAPAPEAAASKPAPRTMGPAAAYPDRIPVIPKEGNPSAETKQASGTETAPLTDAKLQKVEVTIGDEGGKEQSTGEQGKGGSNSADLKAHVAPVQTDAAKPFEPTLTGTTKSEHQPNHGLRDSIMAQVKEGIATRQPAGNGEIAIRLAPAELGELRINVQVVDQHVKVEVLAANSQVREILLSNLDSLKENFSRQNLTMTGFDVSTGTGQGYEQLFHQGKEAGQQGGFRTAYQRGTAETEAPATQAADYYYTDRRDSILDVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="66" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RA5</accession>
    <name>Q39RA5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">TIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514316.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3004"/>
    <dbReference type="EnsemblBacteria" id="ABB33219">
        <property type="protein sequence ID" value="ABB33219"/>
        <property type="gene ID" value="Gmet_3004"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3004"/>
    <dbReference type="eggNOG" id="ENOG502ZAXS">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1174066_0_0_7"/>
    <dbReference type="OrthoDB" id="1992733at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003953">
        <property type="term" value="F:NAD+ nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019677">
        <property type="term" value="P:NAD catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000157">
        <property type="entry name" value="TIR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035897">
        <property type="entry name" value="Toll_tir_struct_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13676">
        <property type="entry name" value="TIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52200">
        <property type="entry name" value="SSF52200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TIR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="236" mass="26921" checksum="83FF18D36D2D95CB" modified="2005-11-22" version="1">MAHSYQVFISFKNSDEQGLPTRDSQLADLLYREFTSRGLDVFYSNLSLPRLGESEYKKCIDDALDSSTVLIAVGTSRENLESKWVRYEWDSFYNDVLSGVKPQGRLFVYYEKMSTKELPRTLRQNQAFPHGLDHLNELSEYIMRALPASPVPKFQDLAICTNCGHQFDQRDPPHCSYHPEPALHVKSLGARDDYREVYRFPCCDSFAFAAIDWARGGTDVPPSRFPGCKQGRCIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RL2</accession>
    <name>Q39RL2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33112.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512830.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2894"/>
    <dbReference type="CAZy" id="GT2">
        <property type="family name" value="Glycosyltransferase Family 2"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33112">
        <property type="protein sequence ID" value="ABB33112"/>
        <property type="gene ID" value="Gmet_2894"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2894"/>
    <dbReference type="eggNOG" id="COG1215">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_075518_0_0_7"/>
    <dbReference type="OMA" id="QTHWEVE"/>
    <dbReference type="OrthoDB" id="1445278at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="SSF53448"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33112.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="337" mass="36974" checksum="9C9079B001242CC8" modified="2012-10-31" version="2">MNDNQPVSIIIPVRPGGEVRAVERLRTVNYPAGSIEVLVAEGCSPSRQRNRAAAMAKGKLVYFLDDDSLVDPAFLQRAVERFVDPRVAAVGGPSLTPATDTFFQRAVGLVISSPFGGGGARNRYRRTGAARPSSERELILCNLAFRRELFLAFGGLDERLYPNEENELMDRLLTDGWLLVHDPELAIYRSQRPSFRAFMRQFFGYGTGRGEQTRIAGLRHGIDFAPAFFLAYLLLLPWAPTLLWFIPLICYGALLIAAAVAAAWQGRAPAAIPLLFILFPTLHLSYGAGLLKGVLRPRFAQSQTEPPAVAVRVIKELGMPWAAAGVARADNDGRLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RL3</accession>
    <name>Q39RL3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2893</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366115.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2893"/>
    <dbReference type="EnsemblBacteria" id="ABB33111">
        <property type="protein sequence ID" value="ABB33111"/>
        <property type="gene ID" value="Gmet_2893"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2893"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_548309_0_0_7"/>
    <dbReference type="OMA" id="HTLWRHA"/>
    <dbReference type="OrthoDB" id="895667at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="497" mass="55523" checksum="DAEE9F1A63DD55DB" modified="2005-11-22" version="1">MTGIRKRTVLLFFLATTVVVYGNTFLNDWTYDDVPVIVQNPDAHSLKGFVENSRPGRPLRELTYIPEYHLFGEKPAGYRVQQLAWHGMNGFLLVLVFGLLGVELPYALLGALFFLVHPLQSESVANLSHRKELLTLFFSLVSLYGYVKAAALAGGRRVAFMAVAVAGYVVALLANETVITLPLLVILVECYGMPRERRILLRRPLLLAVSGAIAAAYLLYTFRGFIRPEQLLTIYSKNSFMASRSYLPLFMGSMTAFGFYLWKIVLPVGLAPEYTFRLAESFLQPWALLSGTLLVVLVTVMVRAARRLPLLSLGIGWFFVFWLPVSNLVPVAYLAADRYMYLCLPGVGLALAVLLQRLRSAKVEAGFCAVLLVLAVLTAIQNGYWRTEHTLWRHAVAVNPDSTWVQETVALSYLLTDETDKAVAHAREAIRLNRLNTRAYLTLAKAEERRGNLAEAVKNYEFFAAYGGMEYPSEAADVQASLPALRERLALQKTNLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RU3</accession>
    <name>Q39RU3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2813</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513992.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2813"/>
    <dbReference type="EnsemblBacteria" id="ABB33031">
        <property type="protein sequence ID" value="ABB33031"/>
        <property type="gene ID" value="Gmet_2813"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2813"/>
    <dbReference type="HOGENOM" id="CLU_142668_1_0_7"/>
    <dbReference type="OMA" id="AWKEMKA"/>
    <dbReference type="OrthoDB" id="2022157at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223308" evidence="2">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="124" mass="14013" checksum="3EF5DC5DF1CC3886" modified="2005-11-22" version="1">MRPFIVATAALLALSILHPPTVPASEEQPAQQEKNGGDTERKASEIGRKIDELDAKMKQATEETKAAFAREMADLRKQQDALREKMEEMKGASGKAWKEMKAGTEKALHELQKSYDRARERFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RV5</accession>
    <name>Q39RV5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2801</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2801"/>
    <dbReference type="EnsemblBacteria" id="ABB33019">
        <property type="protein sequence ID" value="ABB33019"/>
        <property type="gene ID" value="Gmet_2801"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2801"/>
    <dbReference type="eggNOG" id="ENOG503311J">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125332_0_0_7"/>
    <dbReference type="OMA" id="NGPIRRE"/>
    <dbReference type="OrthoDB" id="1821477at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB33019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="152" mass="18199" checksum="3BB4DF45E25C723E" modified="2005-11-22" version="1">MDEENMTEKNFIDLTDSDFEIARWIWKNLVPKSGQADTVQGEILRAIEKLRWEAQENGNINWDYSFEMFIDFLQNKLGNEERFSKETRAEIANDLARLKNFIPPDELENDLQKADLPYIEDDLYDRLTNHLVSFCRLHPEVIQLQKDERQYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S18</accession>
    <name>Q39S18_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Molybdopterin-binding iron-sulfur cluster-binding oxidoreductase MopB-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2738</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511721.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2738"/>
    <dbReference type="EnsemblBacteria" id="ABB32956">
        <property type="protein sequence ID" value="ABB32956"/>
        <property type="gene ID" value="Gmet_2738"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2738"/>
    <dbReference type="eggNOG" id="COG0243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000422_13_3_7"/>
    <dbReference type="OMA" id="CPLDCPD"/>
    <dbReference type="OrthoDB" id="88184at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043546">
        <property type="term" value="F:molybdopterin cofactor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02786">
        <property type="entry name" value="MopB_CT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006657">
        <property type="entry name" value="MoPterin_dinucl-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006655">
        <property type="entry name" value="Mopterin_OxRdtase_prok_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037920">
        <property type="entry name" value="YoaE_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04879">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01568">
        <property type="entry name" value="Molydop_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00926">
        <property type="entry name" value="Molybdop_Fe4S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="SSF50692"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00490">
        <property type="entry name" value="MOLYBDOPTERIN_PROK_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="671" mass="73636" checksum="20FADA2485189EC1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S64</accession>
    <name>Q39S64_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Acyl-CoA synthetase, AMP-forming</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511769.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2692"/>
    <dbReference type="EnsemblBacteria" id="ABB32910">
        <property type="protein sequence ID" value="ABB32910"/>
        <property type="gene ID" value="Gmet_2692"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2692"/>
    <dbReference type="eggNOG" id="COG0318">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000022_59_7_7"/>
    <dbReference type="OMA" id="CEQYISV"/>
    <dbReference type="OrthoDB" id="1015470at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_Synth/Lig"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-binding" evidence="1">
        <location>
            <begin position="15"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding_C" evidence="2">
        <location>
            <begin position="454"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="552" mass="61176" checksum="8DA763AE757671F2" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S86</accession>
    <name>Q39S86_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511791.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2670"/>
    <dbReference type="EnsemblBacteria" id="ABB32888">
        <property type="protein sequence ID" value="ABB32888"/>
        <property type="gene ID" value="Gmet_2670"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2670"/>
    <dbReference type="HOGENOM" id="CLU_161930_0_0_7"/>
    <dbReference type="OMA" id="RNALWSE"/>
    <dbReference type="OrthoDB" id="1812505at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="125" mass="14168" checksum="FC38BAEC53245861" modified="2005-11-22" version="1">MAKGYQANRERQEQIGALGKALAKRAGFACEWCEGKEDLRPWDYRPDEEPSEETLALLCGRCREMADGRRGDLHELREIRNALWSPVPAVAEGVARVLAKSKEAWVREAIEESFIDEAVKVQLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S99</accession>
    <name>Q39S99_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511804.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2657"/>
    <dbReference type="EnsemblBacteria" id="ABB32875">
        <property type="protein sequence ID" value="ABB32875"/>
        <property type="gene ID" value="Gmet_2657"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2657"/>
    <dbReference type="eggNOG" id="ENOG502ZV95">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2117520_0_0_7"/>
    <dbReference type="OMA" id="MTRHTEA"/>
    <dbReference type="OrthoDB" id="2232783at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="114" mass="11970" checksum="E77F7A677F11C3FE" modified="2005-11-22" version="1">MGEITRQARAELRQLPLMLGKLAGGIAAVIGFTAAVVIVTRRPGALDGLLPALLAGCAGVAVFVLSAWALRGRLAGDAAGEPLPARRARTSLLAWGLLLFFAGVFLAWAWFMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SD4</accession>
    <name>Q39SD4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribose-5-phosphate isomerase B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">rpiB-2</name>
        <name evidence="3" type="ordered locus">Gmet_2621</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511840.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2621"/>
    <dbReference type="EnsemblBacteria" id="ABB32840">
        <property type="protein sequence ID" value="ABB32840"/>
        <property type="gene ID" value="Gmet_2621"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2621"/>
    <dbReference type="eggNOG" id="COG0698">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_091396_4_0_7"/>
    <dbReference type="OMA" id="ETHHANQ"/>
    <dbReference type="OrthoDB" id="1346802at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016861">
        <property type="term" value="F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="SSF89623"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR005384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="16077" checksum="8512A434D5BD95C9" modified="2005-11-22" version="1">MRIGIAADHGGFTMKERMAAALREAGYELTDFGAERLDPDDDYPDFVIPLAQAVGEGKLDRGIAFCSSGVGASIAANKVPGARAALIHDDYSAHQGVEHDDMNIICLGSLVVGYAQSWELVRAFLAATFSGAERHRRRLAKVAALEQCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SE5</accession>
    <name>Q39SE5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511851.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2610"/>
    <dbReference type="EnsemblBacteria" id="ABB32829">
        <property type="protein sequence ID" value="ABB32829"/>
        <property type="gene ID" value="Gmet_2610"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2610"/>
    <dbReference type="eggNOG" id="ENOG5033FSP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099393_1_0_7"/>
    <dbReference type="OMA" id="DRWNSAD"/>
    <dbReference type="OrthoDB" id="1980311at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021455">
        <property type="entry name" value="DUF3106"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11304">
        <property type="entry name" value="DUF3106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223059" evidence="2">
        <location>
            <begin position="25"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="162" mass="19988" checksum="4608395106D8E6FE" modified="2005-11-22" version="1">MRKRIGVVAAAGLLMAALLGEAAAAPWERLTPDERQVLKPFEGRWESLPPERQERLRRGAERWRTMTPEEREQARERSRKWRELPREERERIRKRFDEFSKLPPAEQERIRQRYRWFRELPPEERAALREKWRGLSREERRELRDRYRAMTPEQRKDYLKQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SF3</accession>
    <name>Q39SF3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Antitoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511859.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2602"/>
    <dbReference type="EnsemblBacteria" id="ABB32821">
        <property type="protein sequence ID" value="ABB32821"/>
        <property type="gene ID" value="Gmet_2602"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2602"/>
    <dbReference type="eggNOG" id="ENOG50348CE">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2616962_0_0_7"/>
    <dbReference type="OMA" id="IEGYQAT"/>
    <dbReference type="OrthoDB" id="1934494at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013321">
        <property type="entry name" value="Arc_rbn_hlx_hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="78" mass="8873" checksum="668437402EC99D1B" modified="2005-11-22" version="1">MPNTRLNITLPTPIVDDIKALYGQRGLSQFLEEAAREKLEELKKKAHKGLIEGYQSTAEETKEVLKKFESAVTEKRDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SM5</accession>
    <name>Q39SM5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2528</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514523.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2528"/>
    <dbReference type="EnsemblBacteria" id="ABB32749">
        <property type="protein sequence ID" value="ABB32749"/>
        <property type="gene ID" value="Gmet_2528"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2528"/>
    <dbReference type="HOGENOM" id="CLU_128747_5_1_7"/>
    <dbReference type="OrthoDB" id="2089542at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="35" mass="4041" checksum="A8A3AF84EE5CC7B3" modified="2005-11-22" version="1">MATWKCSTCGFTKEGRCKPQKCPQCQEKGNFEKQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SN1</accession>
    <name>MSCL_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large-conductance mechanosensitive channel</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">mscL</name>
        <name type="ordered locus">Gmet_2522</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homopentamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MscL family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39SN1"/>
    <dbReference type="STRING" id="269799.Gmet_2522"/>
    <dbReference type="EnsemblBacteria" id="ABB32743">
        <property type="protein sequence ID" value="ABB32743"/>
        <property type="gene ID" value="Gmet_2522"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2522"/>
    <dbReference type="eggNOG" id="COG1970">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095787_2_3_7"/>
    <dbReference type="OMA" id="AWIIFLM"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00115">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019823">
        <property type="entry name" value="Mechanosensitive_channel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001185">
        <property type="entry name" value="MS_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037673">
        <property type="entry name" value="MSC/AndL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036019">
        <property type="entry name" value="MscL_channel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30266">
        <property type="entry name" value="PTHR30266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01741">
        <property type="entry name" value="MscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01264">
        <property type="entry name" value="MECHCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81330">
        <property type="entry name" value="SSF81330"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00220">
        <property type="entry name" value="mscL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01327">
        <property type="entry name" value="MSCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0407">Ion channel</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000238002" description="Large-conductance mechanosensitive channel">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00115"/>
        </source>
    </evidence>
    <sequence length="145" mass="15602" checksum="8A994FFCA50DC63F" modified="2005-11-22" version="1">MGMMEEFKEFAVKGNVVDLAVGVIIGGAFGKIVTSFVSDIVMPPLGLIMGKVNFTDLFINLSGKPFDSLKAAKDAGAPVISYGVFINTLIDFIIIAFVIFMVIKQINRFKKEPAPAPPNTKECPHCLSAVPIKATKCAFCTSDIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SX2</accession>
    <name>Q39SX2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cheA34H</name>
        <name evidence="7" type="ordered locus">Gmet_2427</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366050.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2427"/>
    <dbReference type="EnsemblBacteria" id="ABB32652">
        <property type="protein sequence ID" value="ABB32652"/>
        <property type="gene ID" value="Gmet_2427"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2427"/>
    <dbReference type="eggNOG" id="COG0643">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000650_3_7_7"/>
    <dbReference type="OMA" id="HGHKPIN"/>
    <dbReference type="OrthoDB" id="305000at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.560">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004105">
        <property type="entry name" value="CheA-like_dim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037006">
        <property type="entry name" value="CheA-like_homodim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036061">
        <property type="entry name" value="CheW-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002545">
        <property type="entry name" value="CheW-lke_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037257">
        <property type="entry name" value="T2SS_E_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01584">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02895">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00260">
        <property type="entry name" value="CheW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01231">
        <property type="entry name" value="H-kinase_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160246">
        <property type="entry name" value="SSF160246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="SSF47226"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50341">
        <property type="entry name" value="SSF50341"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50851">
        <property type="entry name" value="CHEW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HPt" evidence="6">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="315"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="CheW-like" evidence="5">
        <location>
            <begin position="565"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="3">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="702" mass="77191" checksum="01CF0CB0BE87FEF1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SY8</accession>
    <name>Q39SY8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512489.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2411"/>
    <dbReference type="EnsemblBacteria" id="ABB32636">
        <property type="protein sequence ID" value="ABB32636"/>
        <property type="gene ID" value="Gmet_2411"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2411"/>
    <dbReference type="eggNOG" id="COG1550">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149981_2_1_7"/>
    <dbReference type="OMA" id="RARNRFN"/>
    <dbReference type="OrthoDB" id="1813824at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007546">
        <property type="entry name" value="DUF503"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036746">
        <property type="entry name" value="TT1725-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36441">
        <property type="entry name" value="PTHR36441"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04456">
        <property type="entry name" value="DUF503"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103007">
        <property type="entry name" value="SSF103007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="93" mass="10462" checksum="FB5C66784C62114F" modified="2005-11-22" version="1">MFVFSARFHIFLPTDSLKGKRGIVKSLIARARQNFNVAAAEVDLQDVHGETVIAFVTVGGDRARVRHLLDRVEEWIAEERPDVEVVASLIEEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T38</accession>
    <name>Q39T38_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_2361</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513259.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2361"/>
    <dbReference type="EnsemblBacteria" id="ABB32586">
        <property type="protein sequence ID" value="ABB32586"/>
        <property type="gene ID" value="Gmet_2361"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2361"/>
    <dbReference type="eggNOG" id="ENOG5033UH5">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_890703_0_0_7"/>
    <dbReference type="OMA" id="PRKTKAN"/>
    <dbReference type="OrthoDB" id="1545396at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223371" evidence="3">
        <location>
            <begin position="20"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB32586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="326" mass="35371" checksum="2A63AE7950F70F5A" modified="2005-11-22" version="1">MRFLIVAVMLFVVVSPAVAASKNVTYFLDGTRVEGVASAPKGYLELPLPGNYIPGSFRVRPAGSVPVARVDVVPARPDSKAEKEMKDLMERRRTLEDRLKALDVRQEIFKAAAKSQSSKAPRKTKNNPQPLDTIRKGTDYAVTQLEEVYRGRRRAEEGLKTVDARIEALKKEGGIGGSVARVWLSGKGSASYSFLTTGTGWTPFYDFRLRGNGMVEVTVKAQLPGVQRDKVSVVAQNVVDATPDVQAVSVSSNLAPVARFSLPVEREEPFRAPQSGVSFAFRNTTGERLMAGGGACYLNGEYLGAVRFEGSSSGELKDVVAGRLQE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TA2</accession>
    <name>RS20_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsT</name>
        <name type="ordered locus">Gmet_2297</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Binds directly to 16S ribosomal RNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS20 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514501.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39TA2"/>
    <dbReference type="SMR" id="Q39TA2"/>
    <dbReference type="STRING" id="269799.Gmet_2297"/>
    <dbReference type="EnsemblBacteria" id="ABB32522">
        <property type="protein sequence ID" value="ABB32522"/>
        <property type="gene ID" value="Gmet_2297"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2297"/>
    <dbReference type="eggNOG" id="COG0268">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_160655_3_1_7"/>
    <dbReference type="OMA" id="GVIHKNA"/>
    <dbReference type="OrthoDB" id="2005443at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00500">
        <property type="entry name" value="Ribosomal_S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002583">
        <property type="entry name" value="Ribosomal_S20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036510">
        <property type="entry name" value="Ribosomal_S20_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33398">
        <property type="entry name" value="PTHR33398"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01649">
        <property type="entry name" value="Ribosomal_S20p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46992">
        <property type="entry name" value="SSF46992"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00029">
        <property type="entry name" value="S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000236435" description="30S ribosomal protein S20">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="87" mass="9598" checksum="CAD4AF143C3C3D3D" modified="2005-11-22" version="1">MAHHKSALKRIKQNKRKQFRNKSIRSGLRTFIKNVREAVEAKDAAKAKEALQAAIPVIDKAATKGIIHANAASRNVSRLTKLVNTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TA8</accession>
    <name>Q39TA8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ferritin-like domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514507.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2291"/>
    <dbReference type="DNASU" id="3739319"/>
    <dbReference type="EnsemblBacteria" id="ABB32516">
        <property type="protein sequence ID" value="ABB32516"/>
        <property type="gene ID" value="Gmet_2291"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2291"/>
    <dbReference type="eggNOG" id="COG1633">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_125830_3_0_7"/>
    <dbReference type="OMA" id="VENIYAF"/>
    <dbReference type="OrthoDB" id="1634402at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003251">
        <property type="entry name" value="Rubrerythrin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02915">
        <property type="entry name" value="Rubrerythrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="SSF47240"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubrerythrin" evidence="1">
        <location>
            <begin position="4"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="161" mass="18177" checksum="17D2B824D434F58A" modified="2005-11-22" version="1">MNVIDCALKMEEEAAAHYIQLAAASSVDELQRIFSMLAAAEKEHHATLLSMLGNIDPAKAEFKALDEAACAFKPLLGKRDLVSELLKDPDGYQHVVREEEASIKFYEELAGKADNEETRALLKKLADEERRHLSIVENIYSFVENPKTYLAWGEFSNLKEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TB6</accession>
    <name>Q39TB6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">HNH endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_2283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2283"/>
    <dbReference type="EnsemblBacteria" id="ABB32508">
        <property type="protein sequence ID" value="ABB32508"/>
        <property type="gene ID" value="Gmet_2283"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2283"/>
    <dbReference type="eggNOG" id="ENOG5030IJX">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_099810_0_1_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010902">
        <property type="entry name" value="NUMOD4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13392">
        <property type="entry name" value="HNH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07463">
        <property type="entry name" value="NUMOD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="SSF54060"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NUMOD4" evidence="1">
        <location>
            <begin position="5"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="HNHc" evidence="2">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="159" mass="18091" checksum="A886675605A23DFD" modified="2005-11-22" version="1">MTESERWKVVREAREYEVSNNGDIRRIKTRHVLSPSVSKKGCIANLYVGESKKPKALLWHRVVAEAFIDNPDELPCVRHKDGNRSNNNASNLEWSCRSRCMKRAYATGSKKPTRGSKISTPIGVFTHQREAAKAAGLSQSTVAWRIKSDRFPDWYNLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TE2</accession>
    <accession>Q39ZI2</accession>
    <name>Q39TE2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transposase of ISGme9, IS481 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0007</name>
        <name evidence="3" type="ordered locus">Gmet_0093</name>
        <name evidence="4" type="ordered locus">Gmet_0708</name>
        <name evidence="5" type="ordered locus">Gmet_2256</name>
        <name evidence="6" type="ordered locus">Gmet_2593</name>
        <name evidence="7" type="ordered locus">Gmet_3081</name>
    </gene>
    <organism evidence="5 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="5">GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
            <strain evidence="5">GS-15</strain>
        </source>
    </reference>
    <reference evidence="5" key="3">
        <citation type="submission" date="2012-09" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30257.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30342.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0007"/>
    <dbReference type="EnsemblBacteria" id="ABB30257">
        <property type="protein sequence ID" value="ABB30257"/>
        <property type="gene ID" value="Gmet_0007"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30342">
        <property type="protein sequence ID" value="ABB30342"/>
        <property type="gene ID" value="Gmet_0093"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30950">
        <property type="protein sequence ID" value="ABB30950"/>
        <property type="gene ID" value="Gmet_0708"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32482">
        <property type="protein sequence ID" value="ABB32482"/>
        <property type="gene ID" value="Gmet_2256"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32812">
        <property type="protein sequence ID" value="ABB32812"/>
        <property type="gene ID" value="Gmet_2593"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33295">
        <property type="protein sequence ID" value="ABB33295"/>
        <property type="gene ID" value="Gmet_3081"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0007"/>
    <dbReference type="KEGG" id="gme:Gmet_0093"/>
    <dbReference type="KEGG" id="gme:Gmet_0708"/>
    <dbReference type="KEGG" id="gme:Gmet_2256"/>
    <dbReference type="KEGG" id="gme:Gmet_2593"/>
    <dbReference type="KEGG" id="gme:Gmet_3081"/>
    <dbReference type="eggNOG" id="COG2801">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_709319_0_0_7"/>
    <dbReference type="OMA" id="ARNELTH"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="SSF53098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="1">
        <location>
            <begin position="138"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30257.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30342.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="389" mass="44856" checksum="E1F6CDAD6372D676" modified="2005-11-22" version="1">MEDKNKQLRVLAVQRFRNGETPESICTSLGKSRSWLYKWVARQNGDDPVWSDERSRCPQSMPNRTTAEIEEIVKMVRLNLYNKGLFCGAQAILWELEDLGVKPLPSTRTINRILARNELTHRRTGKYEAKGTLYPVLPSALPNQTHQADLVGPCYLTGPIRFYSLNVVDTATVRCGLHSSRSKAGQMVIDGLWEVWKRLGIPERLQVDNAMSFFGSPTHPRGMGPLIRLCLHNDVEPWFIPMAEPWRNGMIEKFNDRYQQRFLGKVIMTSEEELKVGSLTFEQRHNSKYRYSKLKGSTPLKALATSHVQLRFPTEDEPPRHRLKKPEVGKYHAVRLIRSDLKLNIFGECFSVPPETALEYVVATIDVKEQKLKLFLDKNQVEEFDYKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TJ7</accession>
    <name>Q39TJ7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Zinc-dependent hydrolase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365956.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2200"/>
    <dbReference type="EnsemblBacteria" id="ABB32427">
        <property type="protein sequence ID" value="ABB32427"/>
        <property type="gene ID" value="Gmet_2200"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2200"/>
    <dbReference type="eggNOG" id="COG0491">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_082362_0_0_7"/>
    <dbReference type="OMA" id="MQIRTIA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="SSF56281"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactamase_B" evidence="1">
        <location>
            <begin position="5"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="265" mass="28834" checksum="A195B2A21973C5D3" modified="2005-11-22" version="1">MLINGGISCIVPDILEQFRAFRIDDTKIDKLLILHSHFDHVGIVPFFLRRKPGMVLYGSCRSLEVLQKPKALHAINAASRYVIESSGLSESTASCDLEWREGYPGIAVANGDMIDLGGLEVQIFDTPGHSPCSVSAYVPRLEALFPSDAGGVPSGEKIVTYGTSNYGIFEESLCRLKELPIAYYCADHCGYVTGDEAAGFVTASLAAATARRNLMISVYRRTGNLDDAARELAEYCADENIGGIVPPETFVEAQRQILMHLVGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TR3</accession>
    <name>Q39TR3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sec-independent protein translocase protein TatA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pcmP</name>
        <name evidence="7" type="synonym">tatA</name>
        <name evidence="9" type="ordered locus">Gmet_2132</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TatA/E family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513073.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2132"/>
    <dbReference type="EnsemblBacteria" id="ABB32361">
        <property type="protein sequence ID" value="ABB32361"/>
        <property type="gene ID" value="Gmet_2132"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2132"/>
    <dbReference type="eggNOG" id="COG1826">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_086034_6_1_7"/>
    <dbReference type="OMA" id="RIPEIMS"/>
    <dbReference type="OrthoDB" id="1907955at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033281">
        <property type="term" value="C:TAT protein transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043953">
        <property type="term" value="P:protein transport by the Tat complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00236">
        <property type="entry name" value="TatA_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003369">
        <property type="entry name" value="TatA/B/E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006312">
        <property type="entry name" value="TatA/E"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02416">
        <property type="entry name" value="TatA_B_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01411">
        <property type="entry name" value="tatAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="66" mass="7285" checksum="5C1198C38C823A14" modified="2005-11-22" version="1">MFGFGMPEIIILLVIALVVFGPAKLPQLGSALGGAIRNFRKGTEEPTVVNRQNKENHETAERHEKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TU9</accession>
    <name>Q39TU9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513108.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2096"/>
    <dbReference type="EnsemblBacteria" id="ABB32325">
        <property type="protein sequence ID" value="ABB32325"/>
        <property type="gene ID" value="Gmet_2096"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2096"/>
    <dbReference type="eggNOG" id="COG0456">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_127721_0_0_7"/>
    <dbReference type="OMA" id="FIIGEVR"/>
    <dbReference type="OrthoDB" id="1390922at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="SSF55729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="148" mass="16525" checksum="EB9253C73AA868CD" modified="2005-11-22" version="1">MSDQLSIRNAKPSDLNDVISLDTVTSKTEKADYWRGIFDRFVTGGKSDRIFLVAESNGRVVGFIAGEVRAWEFGSPPCGWVFAIAVSPKAREGGIGRRMFDEISARLKQAGVTTVRTMVDRDNKLTLSFFRSMGLRTGRYIELEKPLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="59" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TV6</accession>
    <name>Q39TV6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514577.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32318">
        <property type="protein sequence ID" value="ABB32318"/>
        <property type="gene ID" value="Gmet_2089"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2089"/>
    <dbReference type="eggNOG" id="ENOG50332QF">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_138548_0_0_7"/>
    <dbReference type="OMA" id="PRPRITH"/>
    <dbReference type="OrthoDB" id="1670533at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="116" mass="13492" checksum="BDA0AB54BD872743" modified="2005-11-22" version="1">MKTRLILKPGQRGTKRLSDKYGDNLVCVRFRYDAATRQRIKTVELIVERIDWNPPPEKFSADTLVAVKIEGYEIDHRKKIKEAGGKWNPDKRLWYVRYGAIAGTELEKHIYVDTTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TW1</accession>
    <name>Q39TW1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyferredoxin, putative benzoyl-CoA reductase electron transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">bamE</name>
        <name evidence="8" type="ordered locus">Gmet_2084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HdrA family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365914.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2084"/>
    <dbReference type="EnsemblBacteria" id="ABB32313">
        <property type="protein sequence ID" value="ABB32313"/>
        <property type="gene ID" value="Gmet_2084"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2084"/>
    <dbReference type="eggNOG" id="COG1148">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004231_2_0_7"/>
    <dbReference type="OMA" id="FERILCA"/>
    <dbReference type="OrthoDB" id="1619561at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039650">
        <property type="entry name" value="HdrA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43498">
        <property type="entry name" value="PTHR43498"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="SSF51905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="936"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="7">
        <location>
            <begin position="969"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1014" mass="111535" checksum="D4CC959E7B0D6968" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TY1</accession>
    <name>Q39TY1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2064</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514039.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2064"/>
    <dbReference type="EnsemblBacteria" id="ABB32293">
        <property type="protein sequence ID" value="ABB32293"/>
        <property type="gene ID" value="Gmet_2064"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2064"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_7_1_7"/>
    <dbReference type="OMA" id="EPDRLHR"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="259" mass="28837" checksum="6353345D4E976A48" modified="2005-11-22" version="1">MKTKNKTVPLIKSVDHAFELLEQFRGDASELSLSELGRRLNLPKNNVFRLLATLESRRFIEHNTSTGSYRLGLKAFHLSRMVSRQMRLVNRARPTLEAMVRECNETVCLTVLRDFSIVCLDAVECSQPVRVVPPIGMRLPAHCTAAGKVQLAHLPEDKVAKLLTVHKLERNTPYTIIDPASFKEHLLQIKEHGYAIGREELEVGVTCVATPVRDYSSNVIGAIVLPGPITRFSDDLINGVLIPLAKKGAEEISSQLGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TZ8</accession>
    <name>Q39TZ8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4124 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_2047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514057.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2047"/>
    <dbReference type="EnsemblBacteria" id="ABB32276">
        <property type="protein sequence ID" value="ABB32276"/>
        <property type="gene ID" value="Gmet_2047"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2047"/>
    <dbReference type="HOGENOM" id="CLU_123270_0_0_7"/>
    <dbReference type="OMA" id="RRWVISM"/>
    <dbReference type="OrthoDB" id="1983618at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025392">
        <property type="entry name" value="DUF4124"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13511">
        <property type="entry name" value="DUF4124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223286" description="DUF4124 domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4124" evidence="4">
        <location>
            <begin position="14"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="135"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="177" mass="20423" checksum="84B4F92942FBFE55" modified="2005-11-22" version="1">MKQLIFALAVVMGFSGAARADTYRWVDDKGVVNFTDNPDLIPSKYRKRVRKSPSMTNPAPSPESEPESRPQRQSKPPVNKSDKKPTDSLSEQEWRSRFATLRAELKALQDGLPKKREALNQLHRKRTIYQRPQDRAAYNEQMDKIERDEARIKELEAQLSALDNEASRAGVPFEWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U71</accession>
    <name>Q39U71_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511870.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1974"/>
    <dbReference type="EnsemblBacteria" id="ABB32203">
        <property type="protein sequence ID" value="ABB32203"/>
        <property type="gene ID" value="Gmet_1974"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1974"/>
    <dbReference type="HOGENOM" id="CLU_2649329_0_0_7"/>
    <dbReference type="OMA" id="LGYLFFC"/>
    <dbReference type="OrthoDB" id="2006403at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="76" mass="8219" checksum="DFD7745830BE31B4" modified="2005-11-22" version="1">MAKNQGLALGIAAMALYIIGGILTFIGLYLIVFMHGSDVLGWGEGRSLGYLFFCVGISLSVMGVLFMRIFRNRGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="103" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UC2</accession>
    <name>Q39UC2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">cbcW</name>
        <name evidence="14" type="ordered locus">Gmet_1923</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="10">Binds 2 heme groups non-covalently.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the cytochrome b family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511920.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1923"/>
    <dbReference type="EnsemblBacteria" id="ABB32152">
        <property type="protein sequence ID" value="ABB32152"/>
        <property type="gene ID" value="Gmet_1923"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1923"/>
    <dbReference type="eggNOG" id="COG1290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031114_3_0_7"/>
    <dbReference type="OMA" id="RFFAFHF"/>
    <dbReference type="OrthoDB" id="262439at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070469">
        <property type="term" value="C:respirasome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00284">
        <property type="entry name" value="Cytochrome_b_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005798">
        <property type="entry name" value="Cyt_b/b6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036150">
        <property type="entry name" value="Cyt_b/b6_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00032">
        <property type="entry name" value="Cytochrom_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81648">
        <property type="entry name" value="SSF81648"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51003">
        <property type="entry name" value="CYTB_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="12">
        <location>
            <begin position="7"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_CTER" evidence="13">
        <location>
            <begin position="235"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB32152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="367" mass="41269" checksum="57FE8E13D6ABC19B" modified="2005-11-22" version="1">MSPLKSIYHWLDVRIGVGELVEKRLTGYLLPRSINAWYSLGSVLLIIFTLQVITGILLLVYYVPDAEKAFKSVSAIMNDVPFGWLIRLCHAVGSNMMVAVLLLHMLSVLFMGSYKRPRELNWLTGFILFNLVLAISLTGYLLPWSQLSFWATTVATNSAGAIPVIGNYLVEFLRGGKLVGAPTLGRFFAVHVALLPLLIGAFIGGHLFLLERIGVSTPPFGQKESKNTWMGDQFRYESHPGGIPFFPNYMLQDMTSILIYLAIFFCVIFYIPYIFLPPTAFVPADPYKTPAHIKPEWYFLANYQTLKVFPNELLGLLVQGAVMTFLALLPFIDKGRERHPFKRPLFLACFVGGILLYVAMAVWGHYS</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UD2</accession>
    <name>SYH_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histidine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Histidyl-tRNA synthetase</fullName>
            <shortName evidence="1">HisRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisS</name>
        <name type="ordered locus">Gmet_1913</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-histidine + tRNA(His) = AMP + diphosphate + H(+) + L-histidyl-tRNA(His)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511931.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UD2"/>
    <dbReference type="SMR" id="Q39UD2"/>
    <dbReference type="STRING" id="269799.Gmet_1913"/>
    <dbReference type="EnsemblBacteria" id="ABB32142">
        <property type="protein sequence ID" value="ABB32142"/>
        <property type="gene ID" value="Gmet_1913"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1913"/>
    <dbReference type="eggNOG" id="COG0124">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025113_1_1_7"/>
    <dbReference type="OMA" id="YQIQKVW"/>
    <dbReference type="OrthoDB" id="277998at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43707">
        <property type="entry name" value="PTHR43707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="SSF55681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000016366" description="Histidine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00127"/>
        </source>
    </evidence>
    <sequence length="413" mass="46091" checksum="465CF5454BBF6B48" modified="2005-11-22" version="1">MITGIKGFNDILPGEVERWQHIEATARRVFGLYGYAEIRVPILEKTELFCRSIGDTTDIVEKEMYSFVDKGENAVTMRPEGTASVMRAYIEHKLYAQDPVAKLYYMGPMFRYERPQKGRYRQFHQIGAEVTGVTDPKVDAQVLTMLCHFFAELGLTEPTLQINSLGCPECRPVYREALKSFLRERLDRLCDDCKRRYETNPLRALDCKSAHCKEATADAPAMLDHLCAGCDDHFAATRRHLERAGTPYSINNRMVRGLDYYTRTTFELVTGLLGAQSAVAAGGRYDGLIADLDGPAVPGIGFAMGVERVALLLGQQEFARRPDLFIAALGTEAQDEAFRLMCGLQRLGVSVEMDYEGKSLKSQMRRSDKFNSRFTLIIGSDEMASGRATLKAMDTGTQSDVLLDPTAIAGQVK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UE8</accession>
    <name>HIS3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyl-AMP cyclohydrolase</fullName>
            <shortName evidence="1">PRA-CH</shortName>
            <ecNumber evidence="1">3.5.4.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hisI</name>
        <name type="ordered locus">Gmet_1897</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-5'-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-[(5-phospho-beta-D-ribosylamino)methylideneamino]imidazole-4-carboxamide</text>
            <dbReference type="Rhea" id="RHEA:20049"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58435"/>
            <dbReference type="ChEBI" id="CHEBI:59457"/>
            <dbReference type="EC" id="3.5.4.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 3/9.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PRA-CH family.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.19" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511947.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UE8"/>
    <dbReference type="SMR" id="Q39UE8"/>
    <dbReference type="STRING" id="269799.Gmet_1897"/>
    <dbReference type="EnsemblBacteria" id="ABB32126">
        <property type="protein sequence ID" value="ABB32126"/>
        <property type="gene ID" value="Gmet_1897"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1897"/>
    <dbReference type="eggNOG" id="COG0139">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048577_5_0_7"/>
    <dbReference type="OMA" id="TGYRSCF"/>
    <dbReference type="OrthoDB" id="1842189at2"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00008"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004635">
        <property type="term" value="F:phosphoribosyl-AMP cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.810">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01021">
        <property type="entry name" value="HisI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026660">
        <property type="entry name" value="PRA-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002496">
        <property type="entry name" value="PRib_AMP_CycHydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038019">
        <property type="entry name" value="PRib_AMP_CycHydrolase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01502">
        <property type="entry name" value="PRA-CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141734">
        <property type="entry name" value="SSF141734"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0368">Histidine biosynthesis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000229822" description="Phosphoribosyl-AMP cyclohydrolase">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01021"/>
        </source>
    </evidence>
    <sequence length="125" mass="14305" checksum="201C61CF487A001F" modified="2005-11-22" version="1">MIQIDFQKMGGLIPAIIQDHESGEVLMVAFMDEKTLNLTLESGKTWFFSRTRNKYWMKGEESGNTQEVIEVLTDCDADSVVIKVKQNGPAACHTGNRSCFYVRWEGGQWVEHSNPLFDPKEVYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="102" xmlns="http://uniprot.org/uniprot">
    <accession>Q39V64</accession>
    <name>Q39V64_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Homoserine dehydrogenase</fullName>
            <ecNumber evidence="6 16">1.1.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="primary">hom</name>
        <name evidence="19" type="ordered locus">Gmet_1629</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="19 20" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-homoserine + NAD(+) = H(+) + L-aspartate 4-semialdehyde + NADH</text>
            <dbReference type="Rhea" id="RHEA:15757"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>L-homoserine + NADP(+) = H(+) + L-aspartate 4-semialdehyde + NADPH</text>
            <dbReference type="Rhea" id="RHEA:15761"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57476"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:537519"/>
            <dbReference type="EC" id="1.1.1.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 17">Belongs to the homoserine dehydrogenase family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.3" evidence="6 16"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511435.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1629"/>
    <dbReference type="EnsemblBacteria" id="ABB31860">
        <property type="protein sequence ID" value="ABB31860"/>
        <property type="gene ID" value="Gmet_1629"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1629"/>
    <dbReference type="eggNOG" id="COG0460">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009116_1_0_7"/>
    <dbReference type="OMA" id="LMFYGPG"/>
    <dbReference type="OrthoDB" id="1464088at2"/>
    <dbReference type="UniPathway" id="UPA00050">
        <property type="reaction ID" value="UER00063"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00051">
        <property type="reaction ID" value="UER00465"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004412">
        <property type="term" value="F:homoserine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005106">
        <property type="entry name" value="Asp/hSer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016204">
        <property type="entry name" value="HDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001342">
        <property type="entry name" value="HDH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019811">
        <property type="entry name" value="HDH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01842">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00742">
        <property type="entry name" value="Homoserine_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03447">
        <property type="entry name" value="NAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000098">
        <property type="entry name" value="Homoser_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="SSF55021"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01042">
        <property type="entry name" value="HOMOSER_DHGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="9 16" id="KW-0412">Isoleucine biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11 15 16" id="KW-0521">NADP</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 16" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="ACT" evidence="18">
        <location>
            <begin position="355"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000098-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="ABB31860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="436" mass="46712" checksum="B3905FE1E6595602" modified="2005-11-22" version="1">MNEIKVGLLGLGTIGTGVAKLLMTNADLIAAKVGARITLKKIADLDITTDRGIALPADILTTNADEVLTDPEISVVIELIGGYEPAKRFVLKAIENGKHVVTANKALLALHGEEIYPAAARKGVEVLFEAAVGGGIPVISAIRGNMAANNFSTVFGILNGTCNYILTRMTKEGVDFADVLKKAQELGYAEADPTFDIEGVDTAHKLALLVSLCFGTRVTFSDIHTEGISSLSSVDIKFARDFGYKIKLLAIGKRDGDRVEARVHPTMIPVNNPLADVDGAFNAIRFTGDFIGPVMFYGRGAGMDPTASAVVGDIIEVSRNIVAGIGRRCAPLGYCDEAVATLPLKPMGEIESKYYIRFSAVDRPGVLARISGILGKYDISIESMVQSGRMAGEEVPIVIMTHEARESDVRTALDEIDTFDIITQKSQVIRIEDNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VF3</accession>
    <name>Q39VF3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Aromatic hydrocarbon degradation ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1537</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbbQ/NirQ/NorQ/GpvN family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511529.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1537"/>
    <dbReference type="EnsemblBacteria" id="ABB31771">
        <property type="protein sequence ID" value="ABB31771"/>
        <property type="gene ID" value="Gmet_1537"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1537"/>
    <dbReference type="eggNOG" id="COG0714">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_979077_0_0_7"/>
    <dbReference type="OMA" id="AFHFEPP"/>
    <dbReference type="OrthoDB" id="848248at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013615">
        <property type="entry name" value="CbbQ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08406">
        <property type="entry name" value="CbbQ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA" evidence="2">
        <location>
            <begin position="38"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="294" mass="33013" checksum="F63D29DB660DBD04" modified="2005-11-22" version="1">MSASKQSNLSVPQEDPYFYVSKDVADIFEKIHQLSQKKPVNVLISGRQGCGKSSLVRQYAAIYQNPLSTFQVGILSEPGQLFGEYALEAGETKYKQFLFPEAIQTPNCVIHLEEINRPEHPKALNMLFSLLSDSREVWLEELGQVNVAKGVVFFATLNEGDDFVGTELLDAALRDRFYFLLMDYLPNDVEREVLVKKTGISAVQADDIISALNFLRSHSDLRIDVSTRTALMIGDMMAVGASLRQALAVSLQTSQEALESVLIGLHVNKGYTESVGNEYVLFDHTWQQHTREYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="119" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VY7</accession>
    <name>Q39VY7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (flavodoxin)</fullName>
            <ecNumber evidence="6">1.17.7.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6 7" type="primary">ispG</name>
        <name evidence="7" type="ordered locus">Gmet_1353</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H(+) + H2O + oxidized [flavodoxin] = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + reduced [flavodoxin]</text>
            <dbReference type="Rhea" id="RHEA:43604"/>
            <dbReference type="Rhea" id="RHEA-COMP:10622"/>
            <dbReference type="Rhea" id="RHEA-COMP:10623"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="ChEBI" id="CHEBI:58483"/>
            <dbReference type="ChEBI" id="CHEBI:128753"/>
            <dbReference type="EC" id="1.17.7.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="6">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 5/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the IspG family.</text>
    </comment>
    <dbReference type="EC" id="1.17.7.3" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513155.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1353"/>
    <dbReference type="DNASU" id="3738687"/>
    <dbReference type="EnsemblBacteria" id="ABB31587">
        <property type="protein sequence ID" value="ABB31587"/>
        <property type="gene ID" value="Gmet_1353"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1353"/>
    <dbReference type="eggNOG" id="COG0821">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_042258_0_0_7"/>
    <dbReference type="OMA" id="PTCGRTQ"/>
    <dbReference type="OrthoDB" id="665306at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00096"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046429">
        <property type="term" value="F:4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00159">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011005">
        <property type="entry name" value="Dihydropteroate_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016425">
        <property type="entry name" value="IspG_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004588">
        <property type="entry name" value="IspG_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30454">
        <property type="entry name" value="PTHR30454"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04551">
        <property type="entry name" value="GcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004640">
        <property type="entry name" value="IspG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="SSF51366"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="SSF56014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00612">
        <property type="entry name" value="ispG_gcpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="355" mass="37847" checksum="112C5582853F14AC" modified="2005-11-22" version="1">MIRETRQIHVGNVAIGGGAPCSVQSMCNTDTRDVAATLSQVLSLSSAGCEIVRCAVPDMAAAEALGEIKRQSPIPVIADIHFDYRLALRVLEGGIDGLRLNPGNIGERWKVEEVVKAARERLVPIRIGVNAGSLEKELLEKYGHPTAEAMVESALGHVRILEDIGYDQIKISLKASDVMKTVEAYRLLAQKVDYPLHIGITEAGTIFSGTIKSSVGLGILLADGIGDTMRVSLTGDPVDEVRVGFEILKALGLRQRGINFVSCPTCGRCQINLIGVAQEVENRLAAIDTPLTVAVMGCVVNGPGEAREADVGIAGGKGEGLLFRHGEIVRKVPEAEMADALIAEVEQMAKEKTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="67" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W00</accession>
    <name>Q39W00_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin, AbrB family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513167.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1339"/>
    <dbReference type="EnsemblBacteria" id="ABB31574">
        <property type="protein sequence ID" value="ABB31574"/>
        <property type="gene ID" value="Gmet_1339"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1339"/>
    <dbReference type="eggNOG" id="COG2002">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_158484_8_0_7"/>
    <dbReference type="OMA" id="GCLKYQG"/>
    <dbReference type="OrthoDB" id="1942483at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007159">
        <property type="entry name" value="SpoVT-AbrB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037914">
        <property type="entry name" value="SpoVT-AbrB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04014">
        <property type="entry name" value="MazE_antitoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00966">
        <property type="entry name" value="SpoVT_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89447">
        <property type="entry name" value="SSF89447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01439">
        <property type="entry name" value="lp_hng_hel_AbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SpoVT-AbrB" evidence="1">
        <location>
            <begin position="4"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="89" mass="9958" checksum="7F9CBDE211ACD387" modified="2005-11-22" version="1">METSKLSSKGQIIIPKQVREAHHWQTGMEFVIESVGDGILLRPRKPFPPTRLEDGLGCAGYSGPAKTLAEMEQGILEDLKRKWLKGVNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W80</accession>
    <name>Q39W80_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Nucleoid maintenance protease YeaZ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">yeaZ</name>
        <name evidence="2" type="ordered locus">Gmet_1258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512109.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1258"/>
    <dbReference type="EnsemblBacteria" id="ABB31494">
        <property type="protein sequence ID" value="ABB31494"/>
        <property type="gene ID" value="Gmet_1258"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1258"/>
    <dbReference type="eggNOG" id="COG1214">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_064886_0_0_7"/>
    <dbReference type="OMA" id="PFYLKDF"/>
    <dbReference type="OrthoDB" id="1826274at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022496">
        <property type="entry name" value="T6A_TsaB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="PTHR11735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF11">
        <property type="entry name" value="PTHR11735:SF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="SSF53067"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03725">
        <property type="entry name" value="T6A_YeaZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TsaD" evidence="1">
        <location>
            <begin position="32"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="230" mass="24224" checksum="424613A046E715E5" modified="2005-11-22" version="1">MKLLTVDTSTSTCSVALTIGGSLVAESLLDSERTLSERLLASIDTILRDAGLLLADLDGFGVALGPGSFTGVRIGVSTVKGLALATGKPVAGFSSLAMLALNLPVNSLPVCTLFDARKKEVYAGLYRCGSLPEPLHADCVMAPERFLDLVDGPALFVGNGALRYHELIVETLGDRAVFAPAHCHQPRAAAGAVLALEAFRSGALTLLPFLNPTYIRPSEAELSRMMRETL</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W82</accession>
    <name>DXR_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-deoxy-D-xylulose 5-phosphate reductoisomerase</fullName>
            <shortName evidence="1">DXP reductoisomerase</shortName>
            <ecNumber evidence="1">1.1.1.267</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">1-deoxyxylulose-5-phosphate reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">2-C-methyl-D-erythritol 4-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">dxr</name>
        <name type="ordered locus">Gmet_1256</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH</text>
            <dbReference type="Rhea" id="RHEA:13717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58262"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.267"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5-phosphate: step 1/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DXR family.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.267" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512111.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W82"/>
    <dbReference type="SMR" id="Q39W82"/>
    <dbReference type="STRING" id="269799.Gmet_1256"/>
    <dbReference type="PRIDE" id="Q39W82"/>
    <dbReference type="EnsemblBacteria" id="ABB31492">
        <property type="protein sequence ID" value="ABB31492"/>
        <property type="gene ID" value="Gmet_1256"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1256"/>
    <dbReference type="eggNOG" id="COG0743">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035714_4_0_7"/>
    <dbReference type="OMA" id="PIDSEHF"/>
    <dbReference type="OrthoDB" id="1200722at2"/>
    <dbReference type="UniPathway" id="UPA00056">
        <property type="reaction ID" value="UER00092"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030604">
        <property type="term" value="F:1-deoxy-D-xylulose-5-phosphate reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019288">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00183">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003821">
        <property type="entry name" value="DXP_reductoisomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013644">
        <property type="entry name" value="DXP_reductoisomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013512">
        <property type="entry name" value="DXP_reductoisomerase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026877">
        <property type="entry name" value="DXPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036169">
        <property type="entry name" value="DXPR_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30525">
        <property type="entry name" value="PTHR30525"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08436">
        <property type="entry name" value="DXP_redisom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02670">
        <property type="entry name" value="DXP_reductoisom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13288">
        <property type="entry name" value="DXPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006205">
        <property type="entry name" value="Dxp_reductismrs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69055">
        <property type="entry name" value="SSF69055"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00243">
        <property type="entry name" value="Dxr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0521">NADP</keyword>
    <keyword id="KW-0560">Oxidoreductase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000020266" description="1-deoxy-D-xylulose 5-phosphate reductoisomerase">
        <location>
            <begin position="1"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00183"/>
        </source>
    </evidence>
    <sequence length="384" mass="40965" checksum="408C5922C46A5B3F" modified="2005-11-22" version="1">MKKLTILGSTGSIGTSTLEIVAAHPDRFQVIALTAGSNLELLKQQVEVFRPRLVSVLTADLARQLDRMLSDPKPEIHHGIPGLIAAATAGEADVVVAAIVGAAGLVPTAAAIKAGKDVALANKETLVTAGRIMMDLVRENGVRLYPVDSEHSAVFQSLEGQSGKDVKRIILTASGGPFLNLPLDRLSRVSVADALNHPNWSMGQKITIDSATMMNKGLEVIEARWLFDTPAERIAVNIHPQSIIHSMVEYVDGCVMAQLGVPDMKAPIAYALTYPERIPTGVKPLDLTALSGLTFLAPDYQRFPALKLAYDALAAGESMPAVMNAANEVAVEAFLKGKIGFTGIATSIARTMDAHEPHTLATIEDVLSSDLWAREKSRELIGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W93</accession>
    <name>Q39W93_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ligand-gated TonB-dependent outer membrane channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TonB-dependent receptor family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512124.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1245"/>
    <dbReference type="EnsemblBacteria" id="ABB31481">
        <property type="protein sequence ID" value="ABB31481"/>
        <property type="gene ID" value="Gmet_1245"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1245"/>
    <dbReference type="eggNOG" id="COG4206">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008287_18_5_7"/>
    <dbReference type="OMA" id="SYELQWR"/>
    <dbReference type="OrthoDB" id="71288at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009279">
        <property type="term" value="C:cell outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.170.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039426">
        <property type="entry name" value="BtuB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012910">
        <property type="entry name" value="Plug_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037066">
        <property type="entry name" value="Plug_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000531">
        <property type="entry name" value="TonB-dep_rcpt_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036942">
        <property type="entry name" value="TonB_rcpt_b-brl_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30069">
        <property type="entry name" value="PTHR30069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07715">
        <property type="entry name" value="Plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00593">
        <property type="entry name" value="TonB_dep_Rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0998">Cell outer membrane</keyword>
    <keyword evidence="2 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0798">TonB box</keyword>
    <feature type="domain" description="Plug" evidence="6">
        <location>
            <begin position="64"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="TonB_dep_Rec" evidence="5">
        <location>
            <begin position="231"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="636" mass="70259" checksum="04DB36144FE64FBD" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WA9</accession>
    <name>Q39WA9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Anti-sigma factor, protein serine/threonine kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rsbW</name>
        <name evidence="2" type="ordered locus">Gmet_1228</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512141.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1228"/>
    <dbReference type="EnsemblBacteria" id="ABB31465">
        <property type="protein sequence ID" value="ABB31465"/>
        <property type="gene ID" value="Gmet_1228"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1228"/>
    <dbReference type="eggNOG" id="COG2172">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090336_11_2_7"/>
    <dbReference type="OMA" id="IMNRLMD"/>
    <dbReference type="OrthoDB" id="1832160at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13581">
        <property type="entry name" value="HATPase_c_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="HATPase_c" evidence="1">
        <location>
            <begin position="42"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="144" mass="16556" checksum="FAA9C0138602CF6C" modified="2005-11-22" version="1">MDRKEIEVDIKVPNQTRYLSLIGRIGEDIAKELDRYDGDRDMLAYHINLVLTEAMVNAIKHANANDPDKMVHVYINITDQDLLIRVFDDGQGFNINSIPPPDFDQLEDRGRGIFIIKQLMDTVKYEKINGGNMLEMTKCLRCCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WB0</accession>
    <name>Q39WB0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidylglycerol--prolipoprotein diacylglyceryl transferase</fullName>
            <ecNumber evidence="2">2.5.1.145</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 3" type="primary">lgt</name>
        <name evidence="3" type="ordered locus">Gmet_1227</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol) + L-cysteinyl-[prolipoprotein] = H(+) + S-1,2-diacyl-sn-glyceryl-L-cysteinyl-[prolipoprotein] + sn-glycerol 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:56712"/>
            <dbReference type="Rhea" id="RHEA-COMP:14679"/>
            <dbReference type="Rhea" id="RHEA-COMP:14680"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57685"/>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
            <dbReference type="ChEBI" id="CHEBI:140658"/>
            <dbReference type="EC" id="2.5.1.145"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Lgt family.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.145" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512142.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1227"/>
    <dbReference type="EnsemblBacteria" id="ABB31464">
        <property type="protein sequence ID" value="ABB31464"/>
        <property type="gene ID" value="Gmet_1227"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1227"/>
    <dbReference type="eggNOG" id="COG0682">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_013386_1_0_7"/>
    <dbReference type="OMA" id="TDVPWAI"/>
    <dbReference type="OrthoDB" id="435911at2"/>
    <dbReference type="UniPathway" id="UPA00664"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005887">
        <property type="term" value="C:integral component of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008961">
        <property type="term" value="F:phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042158">
        <property type="term" value="P:lipoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01147">
        <property type="entry name" value="Lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001640">
        <property type="entry name" value="Lgt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30589">
        <property type="entry name" value="PTHR30589"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01790">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00544">
        <property type="entry name" value="lgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01311">
        <property type="entry name" value="LGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)</name>
            <dbReference type="ChEBI" id="CHEBI:64716"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="261" mass="29329" checksum="C3E7CEA71ABD24D0" modified="2005-11-22" version="1">MQLPHIDPVFLRIGPLEFRWYGLMYILGFIAAYFIVLRRARKRSLLLSADDVADIIFYLAVGVILGGRLGYILFYNAPYYLEHPLKIFAVWEGGMSFHGGLIGVVLAGLLVARKKRLGFFTLADLCVLTAPVGLGLGRLGNFINGELYGRVTDMPWGVVFREGGPMPRHPSQLYEAILEGPVLFIILMVVGRKERPAGVAFWTFVSCYGLFRFFVEFFREPDSQLGFIMGPFSMGQLLSFPMFLLGLAMVLIITKKGKRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WD6</accession>
    <name>Q39WD6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Pentapeptide repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1201</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512169.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1201"/>
    <dbReference type="EnsemblBacteria" id="ABB31438">
        <property type="protein sequence ID" value="ABB31438"/>
        <property type="gene ID" value="Gmet_1201"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1201"/>
    <dbReference type="eggNOG" id="COG1357">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040409_0_0_7"/>
    <dbReference type="OMA" id="HANIWIR"/>
    <dbReference type="OrthoDB" id="1483029at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001646">
        <property type="entry name" value="5peptide_repeat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00805">
        <property type="entry name" value="Pentapeptide"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="515" mass="55867" checksum="32561D39B10F0EA1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WG9</accession>
    <name>Q39WG9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquinone/menaquinone biosynthesis C-methyltransferase UbiE</fullName>
            <ecNumber evidence="6">2.1.1.163</ecNumber>
            <ecNumber evidence="6">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Demethylmenaquinone methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ubiE</name>
        <name evidence="8" type="ordered locus">Gmet_1167</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2-demethylmenaquinol + S-adenosyl-L-methionine = a menaquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42640"/>
            <dbReference type="Rhea" id="RHEA-COMP:9539"/>
            <dbReference type="Rhea" id="RHEA-COMP:9563"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18151"/>
            <dbReference type="ChEBI" id="CHEBI:55437"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.1.1.163"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + H(+) + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Quinol/quinone metabolism; menaquinone biosynthesis; menaquinol from 1,4-dihydroxy-2-naphthoate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.163" evidence="6"/>
    <dbReference type="EC" id="2.1.1.201" evidence="6"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1167"/>
    <dbReference type="EnsemblBacteria" id="ABB31405">
        <property type="protein sequence ID" value="ABB31405"/>
        <property type="gene ID" value="Gmet_1167"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1167"/>
    <dbReference type="eggNOG" id="COG2226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_037990_0_0_7"/>
    <dbReference type="OMA" id="VRNFENL"/>
    <dbReference type="UniPathway" id="UPA00079">
        <property type="reaction ID" value="UER00169"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043333">
        <property type="term" value="F:2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043770">
        <property type="term" value="F:demethylmenaquinone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102094">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102955">
        <property type="term" value="F:S-adenosylmethionine:2-demethylmenaquinol-7 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102027">
        <property type="term" value="F:S-adenosylmethionine:2-demethylquinol-8 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009234">
        <property type="term" value="P:menaquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 6" id="KW-0474">Menaquinone biosynthesis</keyword>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="259" mass="29698" checksum="167A5361449882D1" modified="2005-11-22" version="1">MPRKNQDLYHHYPQKDRKFTMYKLSEKGEQIREMFSDIAPRYDFLNRLLSFGIDRRWRRIAVQCARWSEGGKILDVATGTGDVALEIARQTPDSVSIIGIDITEGMVVLGREKVAQSPYARRITLEIAPCEAIPFPDNTFDSVTIAFGIRNVVDRRQGLAEMQRILKPGGRAVILEFSTPRSQFFKRVYYFYFLRLLPAIGGLFSNFSAYKYLPDSVLEFPSQEEFKTLMRSVGFHSTTHRDLTFGIATIYTGEKAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WH9</accession>
    <name>Q39WH9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1157</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513422.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1157"/>
    <dbReference type="EnsemblBacteria" id="ABB31395">
        <property type="protein sequence ID" value="ABB31395"/>
        <property type="gene ID" value="Gmet_1157"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1157"/>
    <dbReference type="eggNOG" id="COG2119">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040186_2_2_7"/>
    <dbReference type="OMA" id="PDKMDDD"/>
    <dbReference type="OrthoDB" id="2050363at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="Gdt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="PTHR12608"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="UPF0016"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="192" mass="20636" checksum="B7EFAA9A10A4F34D" modified="2005-11-22" version="1">MDTAVLMTTFGVIFLAELGDKTQLTAMALAIRYPWKKVFVGIAAAFALLNVGAVLVGKILFAVLPLFWIKFMSGGLFLFFGVTTLRGGEDADEEEGKKASARGPVVTSFVMILLAELGDKTQLVTTSLAAQYDSPLAVFTGSTLALWLVSLIGIFLGRQLIRVVSLYTIQKAAGVLFLVFGVIVLYQAFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WI4</accession>
    <name>Q39WI4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31390.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513417.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1152"/>
    <dbReference type="EnsemblBacteria" id="ABB31390">
        <property type="protein sequence ID" value="ABB31390"/>
        <property type="gene ID" value="Gmet_1152"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1152"/>
    <dbReference type="eggNOG" id="ENOG502ZW4W">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_145322_0_0_7"/>
    <dbReference type="OMA" id="WMQSFER"/>
    <dbReference type="OrthoDB" id="1978207at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31390.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="145" mass="16327" checksum="7F6ED9463DB073CF" modified="2012-10-31" version="2">MEFRLIALTALFVLVAGCAAGDRSMMATRPYPHSHSFYDLLVSWETTGNRGSVTIDGTLKNQSYYYLSDPEITATLLDANGKIIGEGTFLFFPHQFSLDEIAPFTIRIPLKEGEVPKRIRFTYRYRLAEEGMAGSLRFNSFEATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WJ0</accession>
    <name>Q39WJ0_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4157 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513410.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1146"/>
    <dbReference type="EnsemblBacteria" id="ABB31384">
        <property type="protein sequence ID" value="ABB31384"/>
        <property type="gene ID" value="Gmet_1146"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1146"/>
    <dbReference type="eggNOG" id="COG3064">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1041844_0_0_7"/>
    <dbReference type="OrthoDB" id="1722319at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025295">
        <property type="entry name" value="DUF4157"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13699">
        <property type="entry name" value="DUF4157"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4157" evidence="2">
        <location>
            <begin position="142"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="242" mass="26036" checksum="0650730AC321507B" modified="2005-11-22" version="1">MKTFADKLKTSPGPVRRTPVSEVSLYGSPGKNRLEVQQIIRSTKIQPRLVVGTPNDVYEREADHVADAVMRMPDGTVFSGLTGREDDAVQAKSAGEAAPIAGELSEEEEEKLVSLKADGDGEVPLSGELDERIRALEGGGVPLGEGERAFFEPRFGADFSQVRIHTGSAAEEMVRSLNALAFTFGQDIVFGAGHYAPDTPVGRQLLAHELVHTVQQNGRTVIQRGGQDDQEPEGRRDGDSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WM9</accession>
    <name>Q39WM9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Kef-type potassium transporter, NAD-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_1105</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513761.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1105"/>
    <dbReference type="EnsemblBacteria" id="ABB31345">
        <property type="protein sequence ID" value="ABB31345"/>
        <property type="gene ID" value="Gmet_1105"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1105"/>
    <dbReference type="eggNOG" id="COG0475">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG0490">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1226">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_005126_9_0_7"/>
    <dbReference type="OMA" id="IRPFHDV"/>
    <dbReference type="OrthoDB" id="941006at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015299">
        <property type="term" value="F:solute:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006037">
        <property type="entry name" value="RCK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036721">
        <property type="entry name" value="RCK_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003148">
        <property type="entry name" value="RCK_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02080">
        <property type="entry name" value="TrkA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02254">
        <property type="entry name" value="TrkA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116726">
        <property type="entry name" value="SSF116726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51202">
        <property type="entry name" value="RCK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51201">
        <property type="entry name" value="RCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0630">Potassium</keyword>
    <keyword evidence="1" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="RCK N-terminal" evidence="7">
        <location>
            <begin position="410"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="RCK C-terminal" evidence="8">
        <location>
            <begin position="573"/>
            <end position="658"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="672" mass="72528" checksum="4540EE248FE1A3D4" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="60" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WN8</accession>
    <name>Q39WN8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513752.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB31336">
        <property type="protein sequence ID" value="ABB31336"/>
        <property type="gene ID" value="Gmet_1096"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1096"/>
    <dbReference type="HOGENOM" id="CLU_1989441_0_0_7"/>
    <dbReference type="OMA" id="MAPRIYL"/>
    <dbReference type="OrthoDB" id="2101815at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="126" mass="14078" checksum="A7F832930872631B" modified="2005-11-22" version="1">METLYTVMAFITVSVAAILIPRMMIDWQRCREFLRDSDGEALRRFVAEQRQWIVRHGMCAAGAIGMVAVITCAPGMAAYERLAGVMTAYGMMTLTFMFIESLLAQRAESLLQARSASVEQAREFGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WR1</accession>
    <name>Q39WR1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CRISPR-associated endoribonuclease Cas2</fullName>
            <ecNumber evidence="9">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">cas2</name>
        <name evidence="11" type="ordered locus">Gmet_1073</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer, forms a heterotetramer with a Cas1 homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513729.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1073"/>
    <dbReference type="EnsemblBacteria" id="ABB31313">
        <property type="protein sequence ID" value="ABB31313"/>
        <property type="gene ID" value="Gmet_1073"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1073"/>
    <dbReference type="eggNOG" id="COG1343">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_161124_3_1_7"/>
    <dbReference type="OMA" id="CYDVNTE"/>
    <dbReference type="OrthoDB" id="1951170at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043571">
        <property type="term" value="P:maintenance of CRISPR repeat elements"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09725">
        <property type="entry name" value="Cas2_I_II_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01471">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021127">
        <property type="entry name" value="CRISPR_associated_Cas2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019199">
        <property type="entry name" value="Virulence_VapD/CRISPR_Cas2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34405">
        <property type="entry name" value="PTHR34405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09827">
        <property type="entry name" value="CRISPR_Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032582">
        <property type="entry name" value="Cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01573">
        <property type="entry name" value="cas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="5 9 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR032582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB31313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="97" mass="11862" checksum="CA13F3F1C97307F0" modified="2005-11-22" version="1">MWVVVCYDVNTETREGRRRLRRVAQACKNYGQRVQKSVFECQVNEMKFEDLRRKLLREINKEQDNLRFYRLTEPRENHVETHGLTRTIFFDDEPLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WT1</accession>
    <name>Q39WT1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Iron-containing alcohol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_1053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365768.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1053"/>
    <dbReference type="EnsemblBacteria" id="ABB31293">
        <property type="protein sequence ID" value="ABB31293"/>
        <property type="gene ID" value="Gmet_1053"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1053"/>
    <dbReference type="eggNOG" id="COG1454">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007207_0_0_7"/>
    <dbReference type="OMA" id="AKAMWIK"/>
    <dbReference type="OrthoDB" id="1456634at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="PTHR11496"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-ADH" evidence="2">
        <location>
            <begin position="9"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB31293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="382" mass="40366" checksum="E76364A2E14412AC" modified="2005-11-22" version="1">MNISKFVAPEIIFGQGSLSQIGESAARIGASKVFLVSDEDVISAGWVDKALHYLHAVGLETEIYSSLTSNPKDFEVLEGARHYVASGCDAIVAVGGGSPTDVAKAVAILASNGGELRDYEGINRISRPLPPMVIAPSTAGAGSEVSPFAIIVDTERKLKMSIISKSLVPDIAIVDPELLRTKDAKLAAATGMDALTHGIESYVSLAATPLTDIHACKAIQLIAANLRRAVADRGDMEANTNMAMASLTAGIAFSNAILGATHAMTHQVDGLLDQHHGEANASILPHVMEFNLSACPERFKHIAWSLGKDVRNTGQEEGARLAIEGIRELIADIGLAKGLGAMGLREEFIPLLSRNALNDACLVTNPRNATVDDIEAIFRKAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WU9</accession>
    <name>Q39WU9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphate acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pta</name>
        <name evidence="6" type="ordered locus">Gmet_1035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphate acetyltransferase and butyryltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.8" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513208.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1035"/>
    <dbReference type="EnsemblBacteria" id="ABB31275">
        <property type="protein sequence ID" value="ABB31275"/>
        <property type="gene ID" value="Gmet_1035"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1035"/>
    <dbReference type="eggNOG" id="COG0280">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_019723_0_1_7"/>
    <dbReference type="OMA" id="TMLVKMG"/>
    <dbReference type="OrthoDB" id="1301815at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012147">
        <property type="entry name" value="P_Ac_Bu_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004614">
        <property type="entry name" value="P_AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042113">
        <property type="entry name" value="P_AcTrfase_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042112">
        <property type="entry name" value="P_AcTrfase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002505">
        <property type="entry name" value="PTA_PTB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01515">
        <property type="entry name" value="PTA_PTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000428">
        <property type="entry name" value="P_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00651">
        <property type="entry name" value="pta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PTA_PTB" evidence="5">
        <location>
            <begin position="3"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="333" mass="34577" checksum="DB1779840C99FB34" modified="2005-11-22" version="1">MGLMDQIKAKARNKLQTIVLPESYDDRMYAAAQQIVEQGLARVVMLGNADAIAKKAADLGADISKVELIDPASSPKLSDYADALVELRKSKGLTKEEALKLLTAADNLYYAGMMVRQGDAGGEVAGATGTTGDVLRAAFQTVGPAPGIKTVSSFFFMVTKTPSFGENGIIFFADCAVNPNPDAQALADIAVATARNCKAFLDVDARVAMLSFSTKGSATHADVDKVLKAMELAKGIDPALQIDGELQADAALLPKVGERKAPGSAVAGKANVLVFPDLDAGNIAYKLVERVAGAEAIGPIIQGLAKPVNDLSRGCSVDDIVNVAAITAVQAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="120" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X30</accession>
    <name>Q39X30_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="7">Glutamate N-acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">Ornithine acetyltransferase</fullName>
                <shortName evidence="7">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="7">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="7">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="7">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="7">N-acetylglutamate synthase</fullName>
                <shortName evidence="7">AGSase</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="7">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">argJ</name>
        <name evidence="8" type="ordered locus">Gmet_0952</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>L-glutamate + N(2)-acetyl-L-ornithine = L-ornithine + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>acetyl-CoA + L-glutamate = CoA + H(+) + N-acetyl-L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Heterotetramer of two alpha and two beta chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="7">Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the ArgJ family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="7"/>
    <dbReference type="EC" id="2.3.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514435.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0952"/>
    <dbReference type="MEROPS" id="T05.002"/>
    <dbReference type="EnsemblBacteria" id="ABB31194">
        <property type="protein sequence ID" value="ABB31194"/>
        <property type="gene ID" value="Gmet_0952"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0952"/>
    <dbReference type="eggNOG" id="COG1364">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027172_1_0_7"/>
    <dbReference type="OMA" id="DYVHENS"/>
    <dbReference type="OrthoDB" id="1083409at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:acetyl-CoA:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103045">
        <property type="term" value="F:methione N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="PTHR23100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="SSF56266"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023263371" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="7">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023263370" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="7">
        <location>
            <begin position="179"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="393"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="7">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="7">
        <location>
            <begin position="178"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB31194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="393" mass="41142" checksum="29A1D0509634B2EA" modified="2005-11-22" version="1">MNIKGFKFSAVEAAIKKPGRLDLALIVSETPAAVAGVYTTNAVKAAPVLLDQERTKKGACRAIVVNSGNANACTGPVGLADARETTRLVADGVGSAEEEVLVCSTGVIGVPLPMERMRAGIPPLVRGLGTGTFDDVARAIMTTDTFPKMEVRTGKAGGMEYTVAGIAKGAGMIMPNMATMLAFIVTDAAVDPTWLRTVFAAGVERSFNAITVDGDTSTNDTALIMANGAAGNPVLSAGSDDAAEFVRLLDEVLLALAKLIVKDGEGATKFVEITVKGARSDADAKRAAMAVANSCLVKTAFFGQDANWGRIFAAVGYSGAEVDPDRTELFFDDVQMVRAGVFTGGDAEARGTEILKKREFSVTVDLHLGEGVSTVYTSDLSYDYVKINADYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X57</accession>
    <name>Q39X57_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dTDP-4-dehydrorhamnose 3,5-epimerase</fullName>
            <ecNumber evidence="3">5.1.3.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Thymidine diphospho-4-keto-rhamnose 3,5-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">dTDP-4-keto-6-deoxyglucose 3,5-epimerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_0925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-beta-L-rhamnose</text>
            <dbReference type="Rhea" id="RHEA:16969"/>
            <dbReference type="ChEBI" id="CHEBI:57649"/>
            <dbReference type="ChEBI" id="CHEBI:62830"/>
            <dbReference type="EC" id="5.1.3.13"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="5.1.3.13" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513955.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0925"/>
    <dbReference type="EnsemblBacteria" id="ABB31167">
        <property type="protein sequence ID" value="ABB31167"/>
        <property type="gene ID" value="Gmet_0925"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0925"/>
    <dbReference type="eggNOG" id="COG1898">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_090940_3_0_7"/>
    <dbReference type="OMA" id="KAWHYHK"/>
    <dbReference type="OrthoDB" id="1618609at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008830">
        <property type="term" value="F:dTDP-4-dehydrorhamnose 3,5-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000888">
        <property type="entry name" value="dTDP_sugar_isom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21047">
        <property type="entry name" value="PTHR21047"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00908">
        <property type="entry name" value="dTDP_sugar_isom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="SSF51182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="site" description="Participates in a stacking interaction with the thymidine ring of dTDP-4-oxo-6-deoxyglucose" evidence="8">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600888-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB31167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="162" mass="17983" checksum="E7B3F73EC76B965A" modified="2005-11-22" version="1">MQNFPEFKKGKIHDVAVRPLTKFLDERGWLAELFRSDETDAATMPAMAYLSMTQPGVARGPHEHVDQTDWFCFIGPSNFKVYLWDARPTSATFGVKQTIYAGIDAPLAMIVPPGVVHAYKNVGGENGIVFNAPNRLYAGEGKKSPVDEIRHEEVEGSPFTLD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X66</accession>
    <name>PUR7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="1">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">purC</name>
        <name type="ordered locus">Gmet_0916</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + ATP + L-aspartate = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:22628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:77657"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513946.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39X66"/>
    <dbReference type="SMR" id="Q39X66"/>
    <dbReference type="STRING" id="269799.Gmet_0916"/>
    <dbReference type="EnsemblBacteria" id="ABB31158">
        <property type="protein sequence ID" value="ABB31158"/>
        <property type="gene ID" value="Gmet_0916"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0916"/>
    <dbReference type="eggNOG" id="COG0152">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045637_0_0_7"/>
    <dbReference type="OMA" id="TKFEFGF"/>
    <dbReference type="OrthoDB" id="1345271at2"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0658">Purine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000018707" description="Phosphoribosylaminoimidazole-succinocarboxamide synthase">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00137"/>
        </source>
    </evidence>
    <sequence length="296" mass="33042" checksum="ABF8435F6F155713" modified="2005-11-22" version="1">MANLVLKTDFPDLKLVARGKVRDIYDLGEALLIVTTDRISAFDVIMNEGIPDKGYVLTQISAFWFRQMEDIIPNHIISTEVKDFPAECQKYAADLEGRSMLVKKANPLPAECIVRGYISGSGWKDYKATGSICGIKLPAGLVESDKLEEPIFTPSTKAELGTHDENISFDRMVEMMGKELAGKVRDVTIAIYKRARDIADAKGIIIADTKFEYGIYNGELIIIDECMTPDSSRFWPKDSYKPGGAQPSFDKQFLRDYLETLDWNKTAPAPPLPAEIVKKTGEKYMEALVRLTGKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X69</accession>
    <name>Q39X69_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Lipoprotein cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0913</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513943.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0913"/>
    <dbReference type="EnsemblBacteria" id="ABB31155">
        <property type="protein sequence ID" value="ABB31155"/>
        <property type="gene ID" value="Gmet_0913"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0913"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_446728_0_0_7"/>
    <dbReference type="OMA" id="EWRASAH"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="490" mass="51485" checksum="9706F4723F284E1E" modified="2005-11-22" version="1">MKLSKSLTLLLGTAAMVGLYGCGSSNRESAIDQQSASFQASAGCISCHATNKTSPVTGALIVEEWKKSAHNTRSGAACTDCHTNSGHPDGGTIVKAVQDTQCATCHTVASLAYPHFANYTTSLAAQYVSQTDAAGVQCRQCHNPHDTTSLIQYNRDWAESGHGSVEYVAGNASASSVNSHYPWTTASRDACAKCHTTSGYKHVIAGGTAPFLSNNKKNEAIMCSACHSDYSWARRTPGAQTLEYTYAAAAITLDDAGDSNLCLVCHSGRGNMQSARPTRNGSTFHHAVAGAVLFSAKTHVGYEFAGQNYVYAGFKHDTIGMTDGSGPCVSCHMKSTKGHTFGVVTKDSNGAITAINTIATCNACHAGTYALTPAKLEEESAGYQQAGNLLKAKLTAKGIVIPSSGTTAYIAGLAANDYGAWQNSFLTSDEPGGYAHNRKYVKRLIFDSLDWLDNGTFDGTITLSPADVAAYPEAAAWFRADATTGVAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XB5</accession>
    <name>Q39XB5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein S1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsA</name>
        <name evidence="2" type="ordered locus">Gmet_0867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513013.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0867"/>
    <dbReference type="EnsemblBacteria" id="ABB31109">
        <property type="protein sequence ID" value="ABB31109"/>
        <property type="gene ID" value="Gmet_0867"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0867"/>
    <dbReference type="eggNOG" id="COG0539">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015805_2_1_7"/>
    <dbReference type="OMA" id="SLNEFRY"/>
    <dbReference type="OrthoDB" id="1235756at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035104">
        <property type="entry name" value="Ribosomal_protein_S1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022967">
        <property type="entry name" value="S1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10724:SF7">
        <property type="entry name" value="PTHR10724:SF7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00681">
        <property type="entry name" value="RIBOSOMALS1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="47"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="131"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="217"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="302"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="389"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="1">
        <location>
            <begin position="476"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="586" mass="64628" checksum="9780A89BA38AB0D3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XJ5</accession>
    <name>Q39XJ5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Organic solvent tolerance ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0787</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513532.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0787"/>
    <dbReference type="EnsemblBacteria" id="ABB31029">
        <property type="protein sequence ID" value="ABB31029"/>
        <property type="gene ID" value="Gmet_0787"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0787"/>
    <dbReference type="eggNOG" id="COG1127">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_22_7"/>
    <dbReference type="OMA" id="EVFCLIG"/>
    <dbReference type="OrthoDB" id="1058434at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030296">
        <property type="entry name" value="MlaF/Mkl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43023:SF6">
        <property type="entry name" value="PTHR43023:SF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="2"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="248" mass="28110" checksum="C739FD93AABDDCE7" modified="2005-11-22" version="1">MIKLVDIHKSFDSQTVLDGLSLEIPEGKITAVIGPSGEGKSVLLKHMIGLMKPDRGQVHVDGENITAMRRFEMNRVWEKFGMLFQNAALFDSMTVFENVAFPLEEKTRFSRAEIRDRVHNALENVGLRGIDKKYPDELSGGMKKRVGLARALLLNPRIILFDEPTTGLDPIICRAIHQLIRDTHERYGYTAVIVSHEIPEIFDISDQVAMLYRGRITEMGTPEEIRRSEHPVVRQFISGSLEGPIKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XP6</accession>
    <name>Q39XP6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type IV pilus minor pilin PilX</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pilX-1</name>
        <name evidence="3" type="ordered locus">Gmet_0736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514453.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0736"/>
    <dbReference type="EnsemblBacteria" id="ABB30978">
        <property type="protein sequence ID" value="ABB30978"/>
        <property type="gene ID" value="Gmet_0736"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0736"/>
    <dbReference type="eggNOG" id="COG4726">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1624766_0_0_7"/>
    <dbReference type="OMA" id="HATLYEM"/>
    <dbReference type="OrthoDB" id="2008731at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025746">
        <property type="entry name" value="PilX_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14341">
        <property type="entry name" value="PilX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="PilX_N" evidence="2">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="163" mass="18554" checksum="8677B79CB31135AE" modified="2005-11-22" version="1">MGGRVLNERGAALVVAIILLMVLTILMTVLNHATLYEMISSRTYQESQRAFYAAETGVRDALEWLGKQNSPPETTITPPGWFYDGTVARKDATWCSWQTVEDIHFRYYIEHLKDAPNYNMSSTIGKNSKGPKSVQHYYRITVDGANSTYLVHRQVQVVTTAYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XT4</accession>
    <name>Q39XT4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cystathionine gamma-synthase/beta-lyase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">metC-1</name>
        <name evidence="4" type="ordered locus">Gmet_0698</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514089.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0698"/>
    <dbReference type="EnsemblBacteria" id="ABB30940">
        <property type="protein sequence ID" value="ABB30940"/>
        <property type="gene ID" value="Gmet_0698"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0698"/>
    <dbReference type="eggNOG" id="COG0626">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_018986_2_0_7"/>
    <dbReference type="OMA" id="THGGIIV"/>
    <dbReference type="OrthoDB" id="637281at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="PTHR11808"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="391" mass="42775" checksum="098ED902EDFFFDD4" modified="2005-11-22" version="1">MNIATQTAQIGLEWDTRTGAVTVPIYQTATFRHPGLGQSTGYDYTRSGNPTRQALEEGIARLEGGARGFAYASGMAAIANLLLLFKKGDHLVVTEDLYGGTCRLFDQIFTQYELSFTYVDTSDIKAVRAAIRPETKALFVESLTNPLLKVADIAALSALCRERGLLHIVDNTFLTPYLLRPFDHGADITVYSATKYLAGHNDTVSGLVAVKDPQLAERVYFLQNSVGAVLGPQDSWLTIRGMKTLSVRLDRQQENAGRVAQWLSNHPRVRKVYYPGLSGHPGHPGHELLARQARGFGAMIAFEVDEHALVERLLLKTEVISFAESLGGVETLITFPQVQTHADIPPELRQRLGINDVLLRLSVGIEDADDLIDDLAQAFEGGDQGSGTGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XV4</accession>
    <name>Q39XV4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Antitoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0678</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Antitoxin component of a type II toxin-antitoxin (TA) system.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the phD/YefM antitoxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514069.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0678"/>
    <dbReference type="EnsemblBacteria" id="ABB30920">
        <property type="protein sequence ID" value="ABB30920"/>
        <property type="gene ID" value="Gmet_0678"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0678"/>
    <dbReference type="eggNOG" id="COG2161">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_166037_3_2_7"/>
    <dbReference type="OMA" id="YLKSHTA"/>
    <dbReference type="OrthoDB" id="2047723at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006442">
        <property type="entry name" value="Antitoxin_Phd/YefM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036165">
        <property type="entry name" value="YefM-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02604">
        <property type="entry name" value="PhdYeFM_antitox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143120">
        <property type="entry name" value="SSF143120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="99" mass="11042" checksum="C4DE4D744126DD89" modified="2005-11-22" version="1">MKINEDIRPVTYLKSRAADLLAQVNETHRPVIITQNGEARAVLQDPESYEQMRAAIGLLKLVAQGEEDVRAGRVSEQDEIFARLERKLRNGAKGDSDAP</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y11</accession>
    <name>RS12_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">30S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">rpsL</name>
        <name type="ordered locus">Gmet_0621</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">With S4 and S5 plays an important role in translational accuracy.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365696.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y11"/>
    <dbReference type="SMR" id="Q39Y11"/>
    <dbReference type="STRING" id="269799.Gmet_0621"/>
    <dbReference type="EnsemblBacteria" id="ABB30863">
        <property type="protein sequence ID" value="ABB30863"/>
        <property type="gene ID" value="Gmet_0621"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0621"/>
    <dbReference type="eggNOG" id="COG0048">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_104295_1_2_7"/>
    <dbReference type="OMA" id="SPALEKC"/>
    <dbReference type="OrthoDB" id="1707228at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00403_B">
        <property type="entry name" value="Ribosomal_S12_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_S12/S23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_S12_bac"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="PTHR11652"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000238131" description="30S ribosomal protein S12">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-methylthioaspartic acid" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00403"/>
        </source>
    </evidence>
    <sequence length="123" mass="13669" checksum="9E41CE951874DD02" modified="2005-11-22" version="1">MPTINQLIRIGRKSKKEKSNSPALKSCPQKRGVCTRVYTTTPKKPNSALRKVARVRLTNGIEVSSYIPGVGHNLQEHSVVLIRGGRVKDLPGVRYHIVRGTLDSVGVKDRKQARSKYGAKRPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y19</accession>
    <name>Q39Y19_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein translocase subunit SecE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7 8" type="primary">secE</name>
        <name evidence="8" type="ordered locus">Gmet_0613</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell inner membrane</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514629.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0613"/>
    <dbReference type="EnsemblBacteria" id="ABB30855">
        <property type="protein sequence ID" value="ABB30855"/>
        <property type="gene ID" value="Gmet_0613"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0613"/>
    <dbReference type="eggNOG" id="COG0690">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_113663_8_0_7"/>
    <dbReference type="OMA" id="IKKVVWP"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0065002">
        <property type="term" value="P:intracellular protein transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043952">
        <property type="term" value="P:protein transport by the Sec complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005807">
        <property type="entry name" value="SecE_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038379">
        <property type="entry name" value="SecE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33910">
        <property type="entry name" value="PTHR33910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01650">
        <property type="entry name" value="SECETRNLCASE"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00964">
        <property type="entry name" value="secE_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01067">
        <property type="entry name" value="SECE_SEC61G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="61" mass="6731" checksum="A6E86A955500063C" modified="2005-11-22" version="1">MIAKAKDFLTEVKAELGKVTWPTRKETISTTWVVVAIVVIISIYLGACDVILAKLMRLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="80" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y79</accession>
    <name>Q39Y79_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transketolase, B protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">tklB</name>
        <name evidence="2" type="ordered locus">Gmet_0552</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365681.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0552"/>
    <dbReference type="EnsemblBacteria" id="ABB30795">
        <property type="protein sequence ID" value="ABB30795"/>
        <property type="gene ID" value="Gmet_0552"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0552"/>
    <dbReference type="eggNOG" id="COG3958">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009227_1_1_7"/>
    <dbReference type="OMA" id="VINTCDY"/>
    <dbReference type="OrthoDB" id="900125at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="SSF52518"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="SSF52922"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transket_pyr" evidence="1">
        <location>
            <begin position="5"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="314" mass="32540" checksum="EA2674C64C89AC77" modified="2005-11-22" version="1">MSTMIATRDAYGQTLAELGEENSSIVVLDADLSGSTKTSTFAKKFPERFFNMGIAEANMVGTAAGLAAAGKIPFVSTFAIFAVGRAWEQVRQSAAYPKANVKIVATHGGITVGEDGGSHQSVEDIAIMRAVPNMTVIVPADGPETAKAIRAAAAYKGPVYVRLGRNKVPTVTAADAPFEIGKGVQLADGTDLTFVTTGLMTAQALAAAETLKGEGISARVVHLATVKPLDGDILLKAARETGAIVTAEEHSIVGGLGGAVAEFLAENSPVPLKRVGINDRFGTSGKAEELLKYFGLMPIDLVEAARGVVARKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YE0</accession>
    <name>Q39YE0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Periplasmic divalent manganese/zinc-binding lipoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">acdA</name>
        <name evidence="5" type="ordered locus">Gmet_0491</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the bacterial solute-binding protein 9 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512187.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0491"/>
    <dbReference type="EnsemblBacteria" id="ABB30734">
        <property type="protein sequence ID" value="ABB30734"/>
        <property type="gene ID" value="Gmet_0491"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0491"/>
    <dbReference type="eggNOG" id="COG0803">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016838_1_0_7"/>
    <dbReference type="OMA" id="HAAYDYL"/>
    <dbReference type="OrthoDB" id="1703187at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006129">
        <property type="entry name" value="AdhesinB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006128">
        <property type="entry name" value="Lipoprotein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006127">
        <property type="entry name" value="ZnuA-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01297">
        <property type="entry name" value="ZnuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00691">
        <property type="entry name" value="ADHESINB"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00690">
        <property type="entry name" value="ADHESNFAMILY"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223444" evidence="4">
        <location>
            <begin position="18"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="318" mass="34680" checksum="E5071C568F092245" modified="2005-11-22" version="1">MRRIAFMVLVLVLAALASGCRKTEEKGAGGSGKLRIVATIFPVYEFARAVAGDKAEVTLLLPPGMEPHSFEPQPGDIVRVSNADLFIYTNRYMEPWAGEIVKGAGGRKLTVVDASRGAKFLKAGEGNNHDDHGHGGHNHGGEGMDPHLWLDFTNSQLMVDNIAAALAERDPANRSVYLANAAAYRARLADLDERYRKGLASCATRTILHGGHYAFGYLANRYGLRYLSAYAVSADAEPTPAKLAQLVNQVRAEGLKYIFTEELLDPRTAETIARETGASILMLHGAHTVSKADLDRGVTFMELMEKNLKNLREGLQCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YE9</accession>
    <name>Q39YE9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cobalt-sirohydrochlorin C20-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cbiL</name>
        <name evidence="9" type="ordered locus">Gmet_0482</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the precorrin methyltransferase family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513851.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0482"/>
    <dbReference type="EnsemblBacteria" id="ABB30725">
        <property type="protein sequence ID" value="ABB30725"/>
        <property type="gene ID" value="Gmet_0482"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0482"/>
    <dbReference type="eggNOG" id="COG2243">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076014_2_1_7"/>
    <dbReference type="OMA" id="MEYPVTT"/>
    <dbReference type="OrthoDB" id="1209876at2"/>
    <dbReference type="UniPathway" id="UPA00148"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030788">
        <property type="term" value="F:precorrin-2 C20-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11645">
        <property type="entry name" value="Precorrin_2_C20_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012382">
        <property type="entry name" value="CobI/CbiL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006364">
        <property type="entry name" value="CobI/CbiL/CobIJ_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036427">
        <property type="entry name" value="Precrrn-2_mtase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="SSF53790"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01467">
        <property type="entry name" value="cobI_cbiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword evidence="4 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TP_methylase" evidence="8">
        <location>
            <begin position="4"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR036427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="234" mass="25828" checksum="B60CBB7A625B1CA1" modified="2005-11-22" version="1">MTAKIYAVGVGPGDPELLTRKAARIIRSAAVICAPTGAADAASYALSIVEDLIDPSRQEVLPQVFPMRKDQEGLEAFWDEAAAQVAARVRAGRDVAFITIGDPFLYSTFLYLYRIFQERYPDIPVEIVPGISSINAAAAAAGVPLGMAAERIAILPTTYEDDELRRTFADFDTVILMKVNRVFDRIYALLKELGLERKGVFVRRVGSADEEVIFDLERLVGEKLDYLSLLIVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YF8</accession>
    <name>Q39YF8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cobalt ABC transporter, membrane protein CbiN</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">cbiN</name>
        <name evidence="2" type="ordered locus">Gmet_0473</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0473"/>
    <dbReference type="EnsemblBacteria" id="ABB30716">
        <property type="protein sequence ID" value="ABB30716"/>
        <property type="gene ID" value="Gmet_0473"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0473"/>
    <dbReference type="eggNOG" id="ENOG5033HPN">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_2318614_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="93" mass="9966" checksum="3E18973D6F7EADBE" modified="2005-11-22" version="1">MRIFLLVAVLWGGVVLGGWAAAGDKWPGVDETVVEKIAREQGRRAHAPLINTDQGDLLLFAFLAAGAVGGFAAGYWWRMLVTEKGNGSKRGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="65" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YH2</accession>
    <name>Q39YH2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PilZ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513828.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0459"/>
    <dbReference type="EnsemblBacteria" id="ABB30702">
        <property type="protein sequence ID" value="ABB30702"/>
        <property type="gene ID" value="Gmet_0459"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0459"/>
    <dbReference type="HOGENOM" id="CLU_1037303_0_0_7"/>
    <dbReference type="OMA" id="HERMDSW"/>
    <dbReference type="OrthoDB" id="1084216at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035438">
        <property type="term" value="F:cyclic-di-GMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009875">
        <property type="entry name" value="PilZ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040638">
        <property type="entry name" value="PilZN1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18672">
        <property type="entry name" value="DUF5634_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07238">
        <property type="entry name" value="PilZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5634_N" evidence="2">
        <location>
            <begin position="8"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="PilZ" evidence="1">
        <location>
            <begin position="163"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="259" mass="29261" checksum="170A5D00E93314B2" modified="2005-11-22" version="1">MSTEYSNYFEELQKINVAVRLGGGGSFDGTAAITSLKGDLAWLELYGNEQPPRGAVQVGAETWVSVWTGGALCRCDAKVETVRDDRQFSIRLVGEVKETQRREYFRLDVSLPVLYKVLDTVAPEDAEADWNSDRKVFCRPPEMVPTSDGPKVVDWDGEDVVPVRTNLSGGGMRLRVSRLVESGTLVKLTLFLPLPQPRVIYVVAEALRCQEITLSREPGQHYSMSLKFVMIVDRDREAIISYLFNEQRRELMAKNERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YJ5</accession>
    <name>Q39YJ5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Negative regulator of flagellin synthesis</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Anti-sigma-28 factor</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">flgM</name>
        <name evidence="11" type="ordered locus">Gmet_0436</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Responsible for the coupling of flagellin expression to flagellar assembly by preventing expression of the flagellin genes when a component of the middle class of proteins is defective. It negatively regulates flagellar genes by inhibiting the activity of FliA by directly binding to FliA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the FlgM family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512408.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0436"/>
    <dbReference type="EnsemblBacteria" id="ABB30679">
        <property type="protein sequence ID" value="ABB30679"/>
        <property type="gene ID" value="Gmet_0436"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0436"/>
    <dbReference type="eggNOG" id="COG2747">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_182923_0_0_7"/>
    <dbReference type="OMA" id="MIEGAYR"/>
    <dbReference type="OrthoDB" id="1979521at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035890">
        <property type="entry name" value="Anti-sigma-28_factor_FlgM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007412">
        <property type="entry name" value="FlgM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031316">
        <property type="entry name" value="FlgM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04316">
        <property type="entry name" value="FlgM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101498">
        <property type="entry name" value="SSF101498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03824">
        <property type="entry name" value="FlgM_jcvi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="11" id="KW-0966">Cell projection</keyword>
    <keyword evidence="11" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0282">Flagellum</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FlgM" evidence="10">
        <location>
            <begin position="40"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB30679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="97" mass="10239" checksum="E3AA1F490CDDC7A8" modified="2005-11-22" version="1">MTAINDIVSLSSTAAMRPATGEKQAKPVQAPAAGTVQSSDRVELSLGKVQVERLKEIAPAEETVRTDRVAALKQQVAGGSYTVDSRLVAGKMLALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YN3</accession>
    <name>Q39YN3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">23S rRNA (2-N-methyl-G2445)-methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">rlmL</name>
        <name evidence="4" type="ordered locus">Gmet_0398</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512370.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0398"/>
    <dbReference type="EnsemblBacteria" id="ABB30641">
        <property type="protein sequence ID" value="ABB30641"/>
        <property type="gene ID" value="Gmet_0398"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0398"/>
    <dbReference type="eggNOG" id="COG0116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_032119_3_1_7"/>
    <dbReference type="OMA" id="GFMYKAN"/>
    <dbReference type="OrthoDB" id="1772619at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034470">
        <property type="term" value="P:ncRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RNA_methylase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01261">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="58"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="389" mass="43188" checksum="F485769FB7850725" modified="2005-11-22" version="1">MTIIRRKAAAGPFVGEQSFFATTAKGVEEVLAREMTSLGLGGVTMDKGGVRFTGDLSACYRANLWLRTASRILITLTEFPCHSPQDLYDGVRALPWDRYLTPDTTLAVECVLRDSALTHSGFVALKTKDAIVDTLRDRFGRRPSVNPKDPDLLVNVHLVRNRCTISLDSSGTGLDRRGYRAEAGEAPLRETLAAALVLLTDWDGTVPLVDPLCGSGTILIEAVLKALNRAPGLVRERFGFQRWPAFDVPRWRRLLEEARQTERTTLAVPILGSDRLEDVLAVARGNSRRAGVEKFISFEARDLRDLVPPPAPGVILTNPPYGRRLGDEEQLKSFYRQIGDVFKQRCAGYTAWLFTGNLDLAKEVGLKASRRIALFNGPLDCRLLKYDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YS6</accession>
    <name>Q39YS6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">hup-1</name>
        <name evidence="4" type="ordered locus">Gmet_0355</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the bacterial histone-like protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512326.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0355"/>
    <dbReference type="EnsemblBacteria" id="ABB30598">
        <property type="protein sequence ID" value="ABB30598"/>
        <property type="gene ID" value="Gmet_0355"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0355"/>
    <dbReference type="eggNOG" id="COG0776">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_105066_3_1_7"/>
    <dbReference type="OMA" id="DCELTKE"/>
    <dbReference type="OrthoDB" id="1847472at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000119">
        <property type="entry name" value="Hist_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020816">
        <property type="entry name" value="Histone-like_DNA-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010992">
        <property type="entry name" value="IHF-like_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33175">
        <property type="entry name" value="PTHR33175"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00216">
        <property type="entry name" value="Bac_DNA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01727">
        <property type="entry name" value="DNABINDINGHU"/>
    </dbReference>
    <dbReference type="SMART" id="SM00411">
        <property type="entry name" value="BHL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47729">
        <property type="entry name" value="SSF47729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00045">
        <property type="entry name" value="HISTONE_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="94" mass="9693" checksum="64411C999C1648DC" modified="2005-11-22" version="1">MTKAELVDAVAKSANLTKAAADKAVGAVISAVSDALKKGDKVTLVGFGSFEVSTRKARTGRNPQTGKEIKIAAAKVPKFRPGKALKDAVAAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YU6</accession>
    <name>Q39YU6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ppcF</name>
        <name evidence="6" type="ordered locus">Gmet_0335</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512307.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0335"/>
    <dbReference type="EnsemblBacteria" id="ABB30578">
        <property type="protein sequence ID" value="ABB30578"/>
        <property type="gene ID" value="Gmet_0335"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0335"/>
    <dbReference type="eggNOG" id="ENOG50349AP">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_188310_0_0_7"/>
    <dbReference type="OMA" id="KDCKKCH"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002322">
        <property type="entry name" value="Cyt_c_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020942">
        <property type="entry name" value="Cyt_c_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02085">
        <property type="entry name" value="Cytochrom_CIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00609">
        <property type="entry name" value="CYTOCHROMEC3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223320" evidence="4">
        <location>
            <begin position="23"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_CIII" evidence="5">
        <location>
            <begin position="30"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="92" mass="10165" checksum="284BC2DAADB7BBBF" modified="2005-11-22" version="1">MKKTAITIAFVATSAFAAHVFAADVFEFPASMGKVTFPHKMHQEMLKDCKKCHENGPGKIKDFGKDWAHKTCKGCHTELKKGPVGCTDCHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YY7</accession>
    <name>Q39YY7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0292"/>
    <dbReference type="EnsemblBacteria" id="ABB30537">
        <property type="protein sequence ID" value="ABB30537"/>
        <property type="gene ID" value="Gmet_0292"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0292"/>
    <dbReference type="eggNOG" id="COG4412">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4932">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014557_0_0_7"/>
    <dbReference type="OMA" id="GMFESTT"/>
    <dbReference type="OrthoDB" id="924098at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223527" evidence="1">
        <location>
            <begin position="22"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="916" mass="91649" checksum="D19FC4071DC0613E" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YZ0</accession>
    <name>Q39YZ0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0289</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514000.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0289"/>
    <dbReference type="EnsemblBacteria" id="ABB30534">
        <property type="protein sequence ID" value="ABB30534"/>
        <property type="gene ID" value="Gmet_0289"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0289"/>
    <dbReference type="eggNOG" id="ENOG50348QR">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_830950_0_0_7"/>
    <dbReference type="OMA" id="EIEEFAW"/>
    <dbReference type="OrthoDB" id="1635672at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041290">
        <property type="entry name" value="Tli4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18426">
        <property type="entry name" value="Tli4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223326" evidence="1">
        <location>
            <begin position="26"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Tli4_C" evidence="2">
        <location>
            <begin position="204"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="334" mass="37757" checksum="5FDAC28DAF64FC87" modified="2005-11-22" version="1">MKTVFRRALLVITATILTVSFTACKGSAGNGSDHKEPGKGAQKGMNTYNIGRFSIDVPTEMKEAGRTHEFRYAEIEEFLWPKNVDREEARKEAWARRIAEINSNRPPRGIKKIIVETKESLSVGKWSKGVLYYGNDMSSKDGFWMIMADYGQVGAIFIIKGLIEYEEPMFDDLLEIARNYEPMKQDKVDSFHTAYGNITLPYLEQESSYVRFEGHPLDLMLEIEMTETNNVEESGPVERLAAAISTNFAPTVDVKKIRARKKNVAGLEGEELVVRLTDGGESELHFGWEYAGKQDSGEYPLIQIEMESPDGRVEEKLKVWDAILGSMKSLYKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z08</accession>
    <name>Q39Z08_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_0271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513588.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0271"/>
    <dbReference type="EnsemblBacteria" id="ABB30516">
        <property type="protein sequence ID" value="ABB30516"/>
        <property type="gene ID" value="Gmet_0271"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0271"/>
    <dbReference type="eggNOG" id="COG3784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1254970_0_0_7"/>
    <dbReference type="OrthoDB" id="1714881at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008309">
        <property type="entry name" value="UCP025560"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07027">
        <property type="entry name" value="DUF1318"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="220" mass="23774" checksum="0C7691BFD61E9839" modified="2005-11-22" version="1">MPMKIFVWMLAVVAGILASCAFITVNVYFPEKEVKKAFKTLDEKYLGKEGGEAPVPEQPPAGAEPAPAEKPQSRFEGARWPLAVTATAWAAEDAAGGLVVELSRMPEVVKAYEEMRGRLTTLDQLRDGGIVGETNQGLVTVRDPSRIAGLKGAVDEENANRKTVITGMARAILKQAGKPDTPANMGQVLGKAAATYAQTKQETARPGWWIQLQNGKWVQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="69" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z36</accession>
    <name>Q39Z36_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PMT_2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_0243</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0243"/>
    <dbReference type="EnsemblBacteria" id="ABB30488">
        <property type="protein sequence ID" value="ABB30488"/>
        <property type="gene ID" value="Gmet_0243"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0243"/>
    <dbReference type="eggNOG" id="COG1807">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_506944_0_0_7"/>
    <dbReference type="OMA" id="VGPEYLQ"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038731">
        <property type="entry name" value="RgtA/B/C-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13231">
        <property type="entry name" value="PMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="PMT_2" evidence="9">
        <location>
            <begin position="73"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="552" mass="60474" checksum="2A81965B099BBFB9" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z54</accession>
    <name>Q39Z54_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0225</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30470.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512815.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0225"/>
    <dbReference type="EnsemblBacteria" id="ABB30470">
        <property type="protein sequence ID" value="ABB30470"/>
        <property type="gene ID" value="Gmet_0225"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0225"/>
    <dbReference type="eggNOG" id="COG0477">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046685_2_1_7"/>
    <dbReference type="OMA" id="WQAYFLK"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="278"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="1"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30470.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="396" mass="43881" checksum="DA8BD7FDD2C0E630" modified="2012-10-31" version="2">MTSLRRNIPLLYGFSFLQMTLFPMAVITLFWKDHIGLSLSQILLLQSIFAVAMVVMEYPSGYISDRVGYRTALTLASVLGIAGWGVYTVASSFRDVLIAETLLGISTSFISGTDSALLYESLKETGDEAAYGRFEGRSTFFGQTGEAAGALFAGVLYARYPLLPFVLQVAVWVLALLLTRGMAEPPRERHHQVNHLKESLASARYVFIENRRLRVTVLLSIALGLSSFYPVWLIQPYMRNAGVPLASFGPIWAGANLTVAIFAVFSHRLREQLRDRGMIFLLIILVWGGYLGLGLAAGVWGFLFYYLLTAMRGMRGPFLLHVAQAEIPSANRAGMLSLQSLCFRLLFAVTAPLLGRFADAHGVGNSFRLLFFAYLLVLPPLVWLFLRQRHGVGSHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z81</accession>
    <name>Q39Z81_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0197</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365633.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0197"/>
    <dbReference type="EnsemblBacteria" id="ABB30443">
        <property type="protein sequence ID" value="ABB30443"/>
        <property type="gene ID" value="Gmet_0197"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0197"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_435310_0_0_7"/>
    <dbReference type="OMA" id="GNAIFIF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="7">
        <location>
            <begin position="85"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="6">
        <location>
            <begin position="427"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="689"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="710" mass="79070" checksum="4BF0E613832FDE98" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z85</accession>
    <name>Q39Z85_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoribosylaminoimidazole carboxylase-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30439.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512782.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0193"/>
    <dbReference type="EnsemblBacteria" id="ABB30439">
        <property type="protein sequence ID" value="ABB30439"/>
        <property type="gene ID" value="Gmet_0193"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0193"/>
    <dbReference type="eggNOG" id="COG1691">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_065705_0_0_7"/>
    <dbReference type="OMA" id="EVIWGPG"/>
    <dbReference type="OrthoDB" id="1744359at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039476">
        <property type="entry name" value="P2CMN_synthase_LarB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000031">
        <property type="entry name" value="PurE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43064">
        <property type="entry name" value="PTHR43064"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00731">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01001">
        <property type="entry name" value="AIRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AIRC" evidence="1">
        <location>
            <begin position="120"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30439.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="249" mass="26058" checksum="223F1E3710F8592A" modified="2012-10-31" version="2">MDPNELKILLNEFKSGAIGEDEALERLRHLPFEDIGDAMVDHHRSLRQGFPEVIFGAGKSAGQIERIMASLAARGNNILVTRLDEAKALAVKEAFPPAVWHADARCLTLEQKPAERRGRGTVLVVSAGTSDLPVAAEALVTLRMLGNDTEHLYDVGVAGIHRLLARREALTAASVLIVVAGMEGALPSVVGGLVDRPVIAVPTSVGYGAAFGGIAALLGMLNSCAAGVTVVNIDNGFGAAVAASKINRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZD5</accession>
    <name>Q39ZD5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ResB-like family cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_0140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512725.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0140"/>
    <dbReference type="EnsemblBacteria" id="ABB30389">
        <property type="protein sequence ID" value="ABB30389"/>
        <property type="gene ID" value="Gmet_0140"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0140"/>
    <dbReference type="eggNOG" id="COG1333">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1228479_0_0_7"/>
    <dbReference type="OMA" id="PHLMHAG"/>
    <dbReference type="OrthoDB" id="1728166at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023494">
        <property type="entry name" value="Cyt_c_bgen_Ccs1/CcsB/ResB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007816">
        <property type="entry name" value="ResB-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31566">
        <property type="entry name" value="PTHR31566"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05140">
        <property type="entry name" value="ResB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0201">Cytochrome c-type biogenesis</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="ResB" evidence="7">
        <location>
            <begin position="85"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB30389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="236" mass="25749" checksum="41F35C609C43FE99" modified="2005-11-22" version="1">MIKRIYEFLASLSLGLWLMGGVMAFLAAGSFGGEDAASLNEMPLFVWLGAAPFSASWWLWGTLVLLALMVVNTLLCSVEAIRKRYGKSGLLALLAPQLMHAGFLLIVLAHLLSAKGGEKQAMQLFEGSNLRFPGGSFVMVDAIEVETDPRGMPLDYRARMRVVEQGRSTPVTVRPNEPLFHDGVGIYLKQAAPFPYPTAYVEIHREPGAGWALAGALLFTAGNVMLLAVRRERRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZF3</accession>
    <name>Q39ZF3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">Pyruvate kinase</fullName>
            <ecNumber evidence="4 12">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">pyk</name>
        <name evidence="15" type="ordered locus">Gmet_0122</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="15 16" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + pyruvate = ADP + H(+) + phosphoenolpyruvate</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the pyruvate kinase family.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514127.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0122"/>
    <dbReference type="EnsemblBacteria" id="ABB30371">
        <property type="protein sequence ID" value="ABB30371"/>
        <property type="gene ID" value="Gmet_0122"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0122"/>
    <dbReference type="eggNOG" id="COG0469">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_015439_0_2_7"/>
    <dbReference type="OMA" id="MVRVHHL"/>
    <dbReference type="OrthoDB" id="1098983at2"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_Kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PTHR11817"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="SSF50800"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="SSF51621"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="SSF52935"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 15" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PK" evidence="13">
        <location>
            <begin position="6"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="PK_C" evidence="14">
        <location>
            <begin position="357"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="ABB30371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="480" mass="51839" checksum="164CDA0B5410973A" modified="2005-11-22" version="1">MDKSSRKTKIVATLGPASSSPEMISKLMEAGADLFRLNFSHGANDQRRETIATIRRLSAARGKEIGILADLQGPKIRTGRMENGAISLRKGDPLDIVTDEVLGTPTLISTIYKALPHDVKPGSRILMDDGLIELKVHSVEGNLVRCTVVEGGTLKDLKGINLPGVHVSAPSLSEKDLRDLEFCLAEGVDYIALSFVRSAEDVEGLKRILFERGIHIPVVAKIEKPEALRNFKSILKAADGVMVARGDLGVEISAEKVPLFQKKIIRACNEAGKPVITATQMLESMISHPRPTRAETSDVANAILDGTDAVMLSGETASGQFPLEAVRTMAKVALDVERYAQMEDTLPQRRHNPSIAEAVAEAACRAAVTVDARAISVMTQSGSTAALISKFRPPLPIIAFTQSLETRRRLSLYWGVKPLPIGPMTGTDEQIAAVESTFLSAGYRKGDVIVITMGVPVEARGSTNLMKVHKLGTGKFFEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZH5</accession>
    <name>Q39ZH5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cytochrome c/b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">cbcY</name>
        <name evidence="9" type="ordered locus">Gmet_0100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514105.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0100"/>
    <dbReference type="EnsemblBacteria" id="ABB30349">
        <property type="protein sequence ID" value="ABB30349"/>
        <property type="gene ID" value="Gmet_0100"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0100"/>
    <dbReference type="eggNOG" id="COG2864">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_021306_0_0_7"/>
    <dbReference type="OMA" id="VHFFNTH"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012286">
        <property type="entry name" value="Tetrahaem_cytochrome"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14537">
        <property type="entry name" value="Cytochrom_c3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223534" evidence="7">
        <location>
            <begin position="25"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="588"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_c3_2" evidence="8">
        <location>
            <begin position="98"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="618" mass="70145" checksum="9943C19C8A0F8A80" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2022-05-25" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZN6</accession>
    <name>KUP1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable potassium transport system protein kup 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kup1</name>
        <name type="ordered locus">Gmet_0038</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transport of potassium into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513805.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZN6"/>
    <dbReference type="STRING" id="269799.Gmet_0038"/>
    <dbReference type="EnsemblBacteria" id="ABB30288">
        <property type="protein sequence ID" value="ABB30288"/>
        <property type="gene ID" value="Gmet_0038"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0038"/>
    <dbReference type="eggNOG" id="COG3158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008142_4_2_7"/>
    <dbReference type="OMA" id="GHETIIP"/>
    <dbReference type="OrthoDB" id="589903at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01522">
        <property type="entry name" value="Kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023051">
        <property type="entry name" value="K+_uptake_low_affin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000279786" description="Probable potassium transport system protein kup 1">
        <location>
            <begin position="1"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01522"/>
        </source>
    </evidence>
    <sequence length="605" mass="66478" checksum="D0518089E51192B1" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2012-10-31" modified="2021-06-02" version="25" xmlns="http://uniprot.org/uniprot">
    <accession>J9JEM1</accession>
    <name>J9JEM1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="AFR42794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3580"/>
    <dbReference type="EnsemblBacteria" id="AFR42794">
        <property type="protein sequence ID" value="AFR42794"/>
        <property type="gene ID" value="Gmet_3580"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3580"/>
    <dbReference type="HOGENOM" id="CLU_207127_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="AFR42794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="63" mass="6807" checksum="94D4C8912D74EED5" modified="2012-10-31" version="1">MCGSKHHDKHLCSLKSSGEPHRPGTARVECGHCGARTDDPGKVCEPITRPAIGWFSNGSDYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="77" xmlns="http://uniprot.org/uniprot">
    <accession>Q39PT3</accession>
    <name>Q39PT3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nitrilase/amidohydrolase superfamily protein, class 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513692.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3536"/>
    <dbReference type="EnsemblBacteria" id="ABB33741">
        <property type="protein sequence ID" value="ABB33741"/>
        <property type="gene ID" value="Gmet_3536"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3536"/>
    <dbReference type="eggNOG" id="COG0388">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_030130_3_1_7"/>
    <dbReference type="OMA" id="LFDSGYC"/>
    <dbReference type="OrthoDB" id="1650683at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006807">
        <property type="term" value="P:nitrogen compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="SSF56317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="259" mass="29030" checksum="1765D0AF0FE8320E" modified="2005-11-22" version="1">MTRTVKAGAVQFTIKVGDVDVNMRYVEGALRRLAAQGCALAVLPEMWDTGYAYRELNELAKRTPEVVTELGRLSRELGMVIVGSMPEPHGEKVCNTAYVLDRGELVGSYRKIHLFSLMGEDRSLDGGDRWLVVDTSVGRIGVFICYDLRFPELTRRLAVEGAEILVVPAEWPKPRDEHWKALLKARAIENQLFVVAANCCGIQGKLDFFGSSLIIGPKGEHLAEGGYEPCEISATLDFGEMQSWRRQIPCFEDRKPEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q35</accession>
    <name>Q39Q35_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heterodisulfide oxidoreductase, iron-sulfur cluster-binding subunit G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">hdrG</name>
        <name evidence="3" type="ordered locus">Gmet_3427</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514234.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3427"/>
    <dbReference type="EnsemblBacteria" id="ABB33639">
        <property type="protein sequence ID" value="ABB33639"/>
        <property type="gene ID" value="Gmet_3427"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3427"/>
    <dbReference type="eggNOG" id="COG1908">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_095272_1_0_7"/>
    <dbReference type="OMA" id="FPCTGRI"/>
    <dbReference type="OrthoDB" id="1769704at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003813">
        <property type="entry name" value="MvhD/FlpD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02662">
        <property type="entry name" value="FlpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FlpD" evidence="2">
        <location>
            <begin position="13"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="168" mass="18718" checksum="20E39CADD03BEAD5" modified="2005-11-22" version="1">MHVKPNHTFEPKIVAFVCTWCTYAGADLAGTARLQYPANTRVVKFPCTGRIDPVFILRAFQKGADGVLVSGCHPGDCHYMAGNFHARRRFAAFRALLDFIGVDLQRLQFSWVSAAEGGKWVEVATELTERVRALGPMREFKELEAQEQWSGAIDSPELQEAYEAVGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q38</accession>
    <name>Q39Q38_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heterodisulfide oxidoreductase, iron-sulfur cluster-binding subunit C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">hdrC</name>
        <name evidence="5" type="ordered locus">Gmet_3424</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33636.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514231.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3424"/>
    <dbReference type="EnsemblBacteria" id="ABB33636">
        <property type="protein sequence ID" value="ABB33636"/>
        <property type="gene ID" value="Gmet_3424"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3424"/>
    <dbReference type="eggNOG" id="COG1150">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_093432_1_0_7"/>
    <dbReference type="OMA" id="RTYGRQY"/>
    <dbReference type="OrthoDB" id="1319322at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33636.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="194" mass="22263" checksum="AD2839928BB1F1C9" modified="2012-10-31" version="2">MKHSTMRLSIETMNLDFVKKVEALSGSSVRRCFQCGKCSAGCPMRSFMEHPPNRIVRFLQLGQYERVLAGRSIWYCASCETCTTRCPNKVDLAAIMDALRKCSWDAKGPSKESYVQLANRLFIDNIRTYGRQYEMRLAAVFNVKSGQFLKDLMLGPKLITKGKLKVFHQKNKNLAEIEQIFKRIEELRKKGEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q48</accession>
    <name>Q39Q48_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Response regulator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3414</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514221.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3414"/>
    <dbReference type="EnsemblBacteria" id="ABB33626">
        <property type="protein sequence ID" value="ABB33626"/>
        <property type="gene ID" value="Gmet_3414"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3414"/>
    <dbReference type="eggNOG" id="COG0784">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_69_17_7"/>
    <dbReference type="OMA" id="GHNEPDF"/>
    <dbReference type="OrthoDB" id="1630092at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="5"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="139" mass="15064" checksum="61FE61D371DD618E" modified="2005-11-22" version="1">MEKFQVLLVEDNPDDEFLALRALRKQGIDNIVVAHDGEEALARLLGPGSPGGGGEILEPAFILLDLKLPKINGIEVLTALRGNVRTKQVPVIVISSSREETDLKCCRELDVLSCLTKPVDGKEIVGILEKAGLFDIHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="93" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Q59</accession>
    <name>Q39Q59_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Biosynthetic peptidoglycan transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ordered locus">Gmet_3403</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33615.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3403"/>
    <dbReference type="CAZy" id="GT51">
        <property type="family name" value="Glycosyltransferase Family 51"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33615">
        <property type="protein sequence ID" value="ABB33615"/>
        <property type="gene ID" value="Gmet_3403"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3403"/>
    <dbReference type="eggNOG" id="COG0744">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_006354_1_0_7"/>
    <dbReference type="OMA" id="KRSNMIL"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009274">
        <property type="term" value="C:peptidoglycan-based cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016763">
        <property type="term" value="F:pentosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001264">
        <property type="entry name" value="Glyco_trans_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023346">
        <property type="entry name" value="Lysozyme-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036950">
        <property type="entry name" value="PBP_transglycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011812">
        <property type="entry name" value="Pep_trsgly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30400">
        <property type="entry name" value="PTHR30400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00912">
        <property type="entry name" value="Transgly"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53955">
        <property type="entry name" value="SSF53955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="1" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0133">Cell shape</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Transgly" evidence="13">
        <location>
            <begin position="57"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="266"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB33615.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="320" mass="35278" checksum="BD07A20F29FDDF5A" modified="2012-10-31" version="2">MKKMLYLAIGAVVAYGAYIALSLMFLPSVEELKNRRTNMTIQVKDWHGDYHPFTVGPKNRYWTPSGSIPAEMKWAVILAEDSNFYKHEGIDVKAIKNAIKYDLEKKSFARGASTITQQVAKNLFLSREKTISRKVKEIVLAKRMEEELTKGRIIELYLNVVELGPMVYGIGHGARYYFGKPASALTPRECAFLAAMLPGPRVAYNPYKNLDKVLKRSNMILRLLRNKGVLSAGEYQQALGQEPNIAGLQRKVDQSIEKVEATFQNFTGSAGPQEPVPVPASEGEGTVKEAPAALPPAEPAGTTPAEEGKGGAPPVQEEQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QB1</accession>
    <name>Q39QB1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NADH dehydrogenase I, E subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">nuoE-1</name>
        <name evidence="7" type="ordered locus">Gmet_3351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>2Fe-2S cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49601"/>
        </cofactor>
        <text evidence="6">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512577.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3351"/>
    <dbReference type="EnsemblBacteria" id="ABB33563">
        <property type="protein sequence ID" value="ABB33563"/>
        <property type="gene ID" value="Gmet_3351"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3351"/>
    <dbReference type="eggNOG" id="COG1905">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054362_2_1_7"/>
    <dbReference type="OMA" id="CHVQGAE"/>
    <dbReference type="OrthoDB" id="1206880at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000216">
        <property type="entry name" value="NADH_DH_24kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="SSF52833"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4 6" id="KW-0408">Iron</keyword>
    <keyword evidence="5 6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000216-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="173" mass="19220" checksum="397E1B117F8EE301" modified="2005-11-22" version="1">MSNAPAEATNVEETPVEEIDLGPANHVIDKYLTLPGNLMPVLQGIQDEYGYVPKPTIDLVAERLNVYPSQIFGVLTFYAQFHLKPRGRYIIRVCVGTACHVQGAPRIVETFFDKLGISHAETSPDLRYTFEKVACLGACGMAPLAMVNDDTFGKMTVQKVEEIIAEYNQRPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QD3</accession>
    <name>Q39QD3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_3328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512552.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3328"/>
    <dbReference type="EnsemblBacteria" id="ABB33541">
        <property type="protein sequence ID" value="ABB33541"/>
        <property type="gene ID" value="Gmet_3328"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3328"/>
    <dbReference type="eggNOG" id="COG0346">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046006_10_4_7"/>
    <dbReference type="OMA" id="WGKMAVV"/>
    <dbReference type="OrthoDB" id="1984437at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="SSF54593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="116" mass="12801" checksum="8A997B28755449C4" modified="2005-11-22" version="1">MVEAMKNVVVFVRDFEAAKRFYKEQLKLPLTQEGVTMMEFFSGGATLGVAMALTDEAAALAGRHTGITLRVKDIDDFCRELTDTGVRFDQPLEQSPWGKMAVVADPDGNLFALADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QP0</accession>
    <name>Q39QP0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, major facilitator superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_3221</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512660.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3221"/>
    <dbReference type="EnsemblBacteria" id="ABB33434">
        <property type="protein sequence ID" value="ABB33434"/>
        <property type="gene ID" value="Gmet_3221"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3221"/>
    <dbReference type="eggNOG" id="COG2814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_001265_5_12_7"/>
    <dbReference type="OMA" id="WYVVVIC"/>
    <dbReference type="OrthoDB" id="1345431at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17328">
        <property type="entry name" value="MFS_spinster_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="PTHR23505"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="SSF103473"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="MFS" evidence="6">
        <location>
            <begin position="19"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="416" mass="44551" checksum="EAE05CD71E55EE42" modified="2005-11-22" version="1">MHINAPSPPSKSSPYARYVLALLLGVNLLNYIDRQVLYAVFPLIQHDFSLSDTALGLLGSGFMVTYMVSAPLFGWLGDRWSRTRLAAAGLGIWSVATAAAGLAPTYPALLTARTTVGVGEASFGTVSPGLLAEFFDRERRGRILSYFYLAIPVGSALGYLLGGVIGQQWGWHAAFMMVGLPGLLLVLPVWLMREPPRSADAALEQNDNPDNGGYRALFRNRSFIANTLAMAAMTFALGGLAQWIPTFLYREHGLSVSTGNTLFGGLTVVTGICGTLTGGWLGDRLQRRTPKGYLLVSGWGFLLGTPAAAYAILTPSLNHCLGGMFLAEFFLFLNTGPLNTVIVNVTRPAVRAMAFAVNIFFIHALGDAISPTILGRLSDIWGLRTALLSTPVAILVAALFAFVCCHSIEGDMAKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QP8</accession>
    <name>Q39QP8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-monophosphate kinase</fullName>
            <shortName evidence="2">TMP kinase</shortName>
            <shortName evidence="2">Thiamine-phosphate kinase</shortName>
            <ecNumber evidence="2">2.7.4.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 5" type="primary">thiL</name>
        <name evidence="5" type="ordered locus">Gmet_3213</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ATP + thiamine phosphate = ADP + thiamine diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15913"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.16"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine diphosphate from thiamine phosphate: step 1/1.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thiamine-monophosphate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.16" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512651.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3213"/>
    <dbReference type="EnsemblBacteria" id="ABB33426">
        <property type="protein sequence ID" value="ABB33426"/>
        <property type="gene ID" value="Gmet_3213"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3213"/>
    <dbReference type="eggNOG" id="COG0611">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_046964_1_1_7"/>
    <dbReference type="OMA" id="HFRRDWS"/>
    <dbReference type="OrthoDB" id="1016556at2"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00142"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009030">
        <property type="term" value="F:thiamine-phosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016310">
        <property type="term" value="P:phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02194">
        <property type="entry name" value="ThiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02128">
        <property type="entry name" value="TMP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016188">
        <property type="entry name" value="PurM-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006283">
        <property type="entry name" value="ThiL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30270">
        <property type="entry name" value="PTHR30270"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00586">
        <property type="entry name" value="AIRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005303">
        <property type="entry name" value="Thiam_monoph_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="SSF55326"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="SSF56042"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01379">
        <property type="entry name" value="thiL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AIRS" evidence="3">
        <location>
            <begin position="31"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="AIRS_C" evidence="4">
        <location>
            <begin position="156"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="125"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>5</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="329" mass="34703" checksum="4CCFFDE83BBB0FB4" modified="2005-11-22" version="1">MRLREIGEFGLIGRISSRVADGAGVRIGIGDDAAATEPTPGRWLLVTSDMLLEGIHFDLAFTDPYRLGRKSLAVNLSDVAAMGGEPRHFLLSLAVPTGVTVEFLDRFTEGMLDLAREHGVTLIGGDTCRSSNGLVISVTLHGEQVPELVVRRGGARPGDHVFVTGTVGDSALGLELLRRGERRGWAVDRHLDPTPRVRAGLALAGARLPSAMIDVSDGLAADLGHILDLSGVGARLKLDLLPLSPSFRELAPQMTPNPSLLSLTGGEDYELLFTVPADRSEEVAPLLVETGCAATLIGEITDGRGLAVVGPDGREIPVTCGGYNHFAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QW9</accession>
    <name>Q39QW9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Resolvase-like serine recombinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_3142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513857.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3142"/>
    <dbReference type="DNASU" id="3740916"/>
    <dbReference type="EnsemblBacteria" id="ABB33355">
        <property type="protein sequence ID" value="ABB33355"/>
        <property type="gene ID" value="Gmet_3142"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3142"/>
    <dbReference type="eggNOG" id="COG1961">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010686_3_1_7"/>
    <dbReference type="OMA" id="NLLMIMG"/>
    <dbReference type="OrthoDB" id="1791095at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006118">
        <property type="entry name" value="Recombinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006119">
        <property type="entry name" value="Resolv_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036162">
        <property type="entry name" value="Resolvase-like_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00239">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00857">
        <property type="entry name" value="Resolvase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53041">
        <property type="entry name" value="SSF53041"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00397">
        <property type="entry name" value="RECOMBINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51736">
        <property type="entry name" value="RECOMBINASES_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0229">DNA integration</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Resolvase/invertase-type recombinase catalytic" evidence="6">
        <location>
            <begin position="3"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-serine intermediate" evidence="4 5">
        <location>
            <position position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606118-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB33355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="203" mass="22505" checksum="94A638AC7AE92A3D" modified="2005-11-22" version="1">MAKTIAYLRVSTSQQDLKNQKFEILDYAQKNGLSIDDFVEVEISSRKSVEERKIDYLVSMLSQGDRVIVSELSRIGRSTVEVLNIINELASKKVFLIAIKQNLNINGSENLQAKVMVTMFSLFAELERDLISDRTKRALEARKAAGVKLGRPKGATGVSKLDGMEGQITELLRKQVSLSSIAKIFSVSRGTVYSFIATRGLTA</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-21" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39QX7</accession>
    <name>UPPP_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Undecaprenyl-diphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Bacitracin resistance protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Undecaprenyl pyrophosphate phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">uppP</name>
        <name type="ordered locus">Gmet_3133</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>di-trans,octa-cis-undecaprenyl diphosphate + H2O = di-trans,octa-cis-undecaprenyl phosphate + H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:28094"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58405"/>
            <dbReference type="ChEBI" id="CHEBI:60392"/>
            <dbReference type="EC" id="3.6.1.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text>Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the UppP family.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.27" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514308.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39QX7"/>
    <dbReference type="SMR" id="Q39QX7"/>
    <dbReference type="STRING" id="269799.Gmet_3133"/>
    <dbReference type="EnsemblBacteria" id="ABB33347">
        <property type="protein sequence ID" value="ABB33347"/>
        <property type="gene ID" value="Gmet_3133"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3133"/>
    <dbReference type="eggNOG" id="COG1968">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_060296_1_0_7"/>
    <dbReference type="OMA" id="IEGPFRD"/>
    <dbReference type="OrthoDB" id="1826154at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050380">
        <property type="term" value="F:undecaprenyl-diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016311">
        <property type="term" value="P:dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009252">
        <property type="term" value="P:peptidoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046677">
        <property type="term" value="P:response to antibiotic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01006">
        <property type="entry name" value="Undec_diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003824">
        <property type="entry name" value="UppP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30622">
        <property type="entry name" value="PTHR30622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02673">
        <property type="entry name" value="BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00753">
        <property type="entry name" value="undec_PP_bacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0046">Antibiotic resistance</keyword>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0133">Cell shape</keyword>
    <keyword id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0573">Peptidoglycan synthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <feature type="chain" id="PRO_0000227619" description="Undecaprenyl-diphosphatase">
        <location>
            <begin position="1"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01006"/>
        </source>
    </evidence>
    <sequence length="269" mass="28565" checksum="747E26482FF33783" modified="2005-11-22" version="1">MNPLHATVLGAIQGLTEVLPVSSSAHLILIPWLFGWPESGITFDVALHLGTLIALALYFRRDIAELVVNALSGLTGGAHSSATRLPWYIIAGCVPAAIVGKTLEEPIEAIFRANPAIIAAFLIGFGLLLALADTLGSKKSRMDQIDLKNAMMIGLAQCLALLPGVSRSGITITAALFLGFSRETAARFSFLLSLPIVAGAALLKVGHLVRHGVPEGELQPLLIGVGVSAVFGYVSVALLLKLVQRYSLYPFVWYRLLAGAGVLLFIFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R02</accession>
    <name>Q39R02_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flagellar FliJ protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">fliJ</name>
        <name evidence="12" type="ordered locus">Gmet_3108</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FliJ family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514283.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3108"/>
    <dbReference type="EnsemblBacteria" id="ABB33322">
        <property type="protein sequence ID" value="ABB33322"/>
        <property type="gene ID" value="Gmet_3108"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3108"/>
    <dbReference type="eggNOG" id="COG2882">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139638_2_0_7"/>
    <dbReference type="OMA" id="QECAQRQ"/>
    <dbReference type="OrthoDB" id="1950424at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009288">
        <property type="term" value="C:bacterial-type flagellum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044781">
        <property type="term" value="P:bacterial-type flagellum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071973">
        <property type="term" value="P:bacterial-type flagellum-dependent cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012823">
        <property type="entry name" value="Flagell_FliJ"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02050">
        <property type="entry name" value="FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02473">
        <property type="entry name" value="flagell_FliJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1005">Bacterial flagellum biogenesis</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0966">Cell projection</keyword>
    <keyword evidence="7" id="KW-0145">Chemotaxis</keyword>
    <keyword evidence="12" id="KW-0969">Cilium</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="29"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB33322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="148" mass="17513" checksum="10A72D1D773876D2" modified="2005-11-22" version="1">MMQNHNNGFQLQQVLNYRKEIEKVRKVEFATAKREFESATEVLERHKAEADQARVEYNNKQASVVNAAELQMYADFFRRKTGDIQSQRVQVDSLGREMTERREELMDAAKDKKALELLKERQMAALRRERAEKERAFLEELAIQKAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="99" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R19</accession>
    <name>Q39R19_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome c peroxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">macA</name>
        <name evidence="11" type="ordered locus">Gmet_3091</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
        <text evidence="6">Binds 2 heme groups.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="6">Binds 2 heme groups per subunit.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514545.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3091"/>
    <dbReference type="PeroxiBase" id="3761">
        <property type="entry name" value="GmeDiHCcP_GS-15"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB33305">
        <property type="protein sequence ID" value="ABB33305"/>
        <property type="gene ID" value="Gmet_3091"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3091"/>
    <dbReference type="eggNOG" id="COG1858">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034652_1_1_7"/>
    <dbReference type="OMA" id="YKFANVG"/>
    <dbReference type="OrthoDB" id="52724at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004852">
        <property type="entry name" value="Di-haem_cyt_c_peroxidsae"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026259">
        <property type="entry name" value="MauG/Cytc_peroxidase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03150">
        <property type="entry name" value="CCP_MauG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00034">
        <property type="entry name" value="Cytochrom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000294">
        <property type="entry name" value="Cytochrome-c_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="SSF46626"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0574">Periplasm</keyword>
    <keyword evidence="11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="10">
        <location>
            <begin position="51"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c" evidence="10">
        <location>
            <begin position="205"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>1</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="6">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
            <label>2</label>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000294-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000294-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="346" mass="36879" checksum="0EE1CFE599654572" modified="2005-11-22" version="1">MERKAIACAAVLALVVGTAWGKDDVMGRAKGIFKPIPAKAKALKGNPATPAKVELGKMLYFDPRLSSSQLISCNTCHNVGLAGADLQETAIGHGWQKGPRNSPTVLNAVYNIAQFWDGRAEDLAAQAKGPVQASVEMNNKPENLVATLKSIPGYQPLFRKAFPGEKDPVTFDNVAKAIEVFEATLVTPDAPFDRYLNGNKKALTAAEEQGLALFLDKGCVACHSGINVGGTGYFPFGVKESPGPEIRPEGDTGRFKVTNTAADKYVFRSPSLRNAAITMPYFHSGKVWALKDAVKIMGGAQLGISLTDDDAGKITAFLGSLTGKQPKVMHPILPPNSDTTPRPMTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R51</accession>
    <name>Q39R51_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ordered locus">Gmet_3058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513618.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3058"/>
    <dbReference type="EnsemblBacteria" id="ABB33273">
        <property type="protein sequence ID" value="ABB33273"/>
        <property type="gene ID" value="Gmet_3058"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3058"/>
    <dbReference type="eggNOG" id="COG0553">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG1061">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_287543_0_0_7"/>
    <dbReference type="OMA" id="VMCRTER"/>
    <dbReference type="OrthoDB" id="20073at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="1"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="2">
        <location>
            <begin position="757"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB33273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="993" mass="111953" checksum="5A8877A685CF4B55" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="101" xmlns="http://uniprot.org/uniprot">
    <accession>Q39R82</accession>
    <name>Q39R82_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_3027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514341.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_3027"/>
    <dbReference type="EnsemblBacteria" id="ABB33242">
        <property type="protein sequence ID" value="ABB33242"/>
        <property type="gene ID" value="Gmet_3027"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_3027"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_7_1_7"/>
    <dbReference type="OMA" id="RHSMRMF"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="74"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB33242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="260" mass="29657" checksum="4973A4CC1A4D82A6" modified="2005-11-22" version="1">MAKKDKSEYIIQAVDHALDLLEQFHEDVDELGVTELSKRLKLHKNNVFRLLATLESRGYIEQNRVTENYRLGLKTLELGQTFIKQMGLLRQSRPVLEWLVKECNETAYVAILKEQSIVYLDVVETDLTVRVVPRVGSRLPAYCTAAGKVQIAYMPDEELDAFFPVKELKPYTPNTITDRDVLRKHLMEVAEQGYAIDNEELDLGVRCAGAPIRDYTRRIIGAVSLSGPSMRFTDERMAKELIPLITQAADEISMKLGYHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RB5</accession>
    <name>Q39RB5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Probable endonuclease 4</fullName>
            <ecNumber evidence="9">3.1.21.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Endodeoxyribonuclease IV</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Endonuclease IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9 11" type="primary">nfo</name>
        <name evidence="11" type="ordered locus">Gmet_2994</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="11 12" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Endonucleolytic cleavage to 5'-phosphooligonucleotide end-products.</text>
            <dbReference type="EC" id="3.1.21.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 3 Zn(2+) ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.21.2" evidence="9"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514485.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2994"/>
    <dbReference type="EnsemblBacteria" id="ABB33209">
        <property type="protein sequence ID" value="ABB33209"/>
        <property type="gene ID" value="Gmet_2994"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2994"/>
    <dbReference type="eggNOG" id="COG0648">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_025885_0_1_7"/>
    <dbReference type="OMA" id="HPGSHLK"/>
    <dbReference type="OrthoDB" id="1088517at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008833">
        <property type="term" value="F:deoxyribonuclease IV (phage-T4-induced) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="PTHR21445"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="SSF51658"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AP_endonuc_2" evidence="10">
        <location>
            <begin position="22"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="ABB33209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="285" mass="31593" checksum="5B68EE2D92761070" modified="2005-11-22" version="1">MDYFGAHMSIAGGLHNAPDRGVKVGCGVIQIFTQNSNQWRGKIPSDSDVALFREKWAESGLHEIICHDIYLINLAAPEGETRDKSLLSFREEMERCARLGIDKIVMHPGAHVGDGEETGIKRICEAFDALIPAVPEFTGKILLETTAGQGTNLGYTFEHLRAIIDGSAHPDRFAVCYDTCHTFAAGYDITTPEGYKQVFADFDRIIGIDRLQCFHINDSKKGLNCRVDRHEHIGQGAMGLEGFRTLVNDPRFAKVPKILETPKGDNDEFDVMNLKTLRGLMAGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RD7</accession>
    <name>Q39RD7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Antitoxin, XRE family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2972</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB33187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512905.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2972"/>
    <dbReference type="EnsemblBacteria" id="ABB33187">
        <property type="protein sequence ID" value="ABB33187"/>
        <property type="gene ID" value="Gmet_2972"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2972"/>
    <dbReference type="eggNOG" id="COG3093">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_140230_5_1_7"/>
    <dbReference type="OMA" id="QFWMNLQ"/>
    <dbReference type="OrthoDB" id="2063007at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013430">
        <property type="entry name" value="Toxin_antidote_HigA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36924">
        <property type="entry name" value="PTHR36924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="SSF47413"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02607">
        <property type="entry name" value="antidote_HigA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="1">
        <location>
            <begin position="24"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB33187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="101" mass="11615" checksum="4B1F69F2A6F46BCA" modified="2005-11-22" version="1">MNPTNRMRPIHPGEVLREEFLIPLGMSAHALALELKVPAPRINDIVRERRAVTPDTALRLARYFGTTPQFWLNLQTSYDLKIAERELGSKIEREVHTRLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="62" xmlns="http://uniprot.org/uniprot">
    <accession>Q39RZ7</accession>
    <name>Q39RZ7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1722 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511702.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2759"/>
    <dbReference type="EnsemblBacteria" id="ABB32977">
        <property type="protein sequence ID" value="ABB32977"/>
        <property type="gene ID" value="Gmet_2759"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2759"/>
    <dbReference type="eggNOG" id="COG1683">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3272">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_076318_0_0_7"/>
    <dbReference type="OMA" id="CGLERVK"/>
    <dbReference type="OrthoDB" id="1757306at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007553">
        <property type="entry name" value="2-thiour_desulf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013560">
        <property type="entry name" value="DUF1722"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017087">
        <property type="entry name" value="UCP037004"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04463">
        <property type="entry name" value="2-thiour_desulf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08349">
        <property type="entry name" value="DUF1722"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037004">
        <property type="entry name" value="UCP037004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1722" evidence="1">
        <location>
            <begin position="198"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="323" mass="36871" checksum="A089EBCF212267F2" modified="2005-11-22" version="1">MFMPEAVNWNRPIKVGVSSCLLGEKVRYDGGHKHDHYITDVLGKFFTFVPVCPEVGCGMPVPREAMRLEGDPEHPRLVTNKTRIDKTEQMRAFCKQKVTELADEELCGFIFKKDSPSSGLFRVKVHNEGMPTRSGSGLFAAAVVKHFPLLPAEEEGRLNDAAIRENFIERIFCYRRWKDFLLDSPDLGHLVTFHARHKLLILAHSTSIYREMGSLVAHGKGMSWPELAQSYEALFMKALALHATVKKNTNVLTHIMGYFKRDLSPAEKEELLGVIKEYHDRLVPLIVPLTLLKHYVGKYGQSYLQQQYYLSPHPAELMLRNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="70" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S06</accession>
    <name>Q39S06_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UroD-like decarboxylase/methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511709.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2750"/>
    <dbReference type="EnsemblBacteria" id="ABB32968">
        <property type="protein sequence ID" value="ABB32968"/>
        <property type="gene ID" value="Gmet_2750"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2750"/>
    <dbReference type="eggNOG" id="COG0407">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_040933_2_0_7"/>
    <dbReference type="OMA" id="IHICGRL"/>
    <dbReference type="OrthoDB" id="1104410at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004853">
        <property type="term" value="F:uroporphyrinogen decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006779">
        <property type="term" value="P:porphyrin-containing compound biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000257">
        <property type="entry name" value="Uroporphyrinogen_deCOase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01208">
        <property type="entry name" value="URO-D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="SSF51726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Uroporphyrinogen_deCOase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="340" mass="35524" checksum="720AAB1576830DDE" modified="2005-11-22" version="1">MTAAERVMAVFTGEKPDRPPFALTLSLYGARLINAPLASYYADPALYAQGQVRVAELVSPDIIFAPFALALEAEAYGAELRYHPDGPPMVRRHPFRAPRDAASLSPPAIDTCPGLAYLCESVRRLADHFCGSVPLAGVLTAPVDLPAMLMGLDGWLETLLFEPALAETVLAAATEHFAAMAGALAAAGAACIAIPLMLANPTLVTPEVISRSIVPPLAQAFARTPIPIILHHGGNPAMPFLPLVKDLPNVAGFVIGPGDSFAAARSIVGEEKLILGNLNGPVLNRLTPEQAGARAAAILADRRDDPHFVLASSSADVPLDTPLETLLAVRAAVEGHGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S20</accession>
    <name>Q39S20_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, periplasmic substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511723.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2736"/>
    <dbReference type="EnsemblBacteria" id="ABB32954">
        <property type="protein sequence ID" value="ABB32954"/>
        <property type="gene ID" value="Gmet_2736"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2736"/>
    <dbReference type="eggNOG" id="COG2984">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058196_4_2_7"/>
    <dbReference type="OMA" id="FAMVPYY"/>
    <dbReference type="OrthoDB" id="1729219at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007487">
        <property type="entry name" value="ABC_transpt-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35271">
        <property type="entry name" value="PTHR35271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04392">
        <property type="entry name" value="ABC_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223201" evidence="1">
        <location>
            <begin position="22"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="287" mass="31219" checksum="B7C4C96C4692E993" modified="2005-11-22" version="1">MNRLILHILAVLLLWGFPAFAAEVVVVQGERLAPFEAAFHGFKDTAGVRSVERFVLSDLRGADVVRAVREARPRLVLAVGRDALARVRDIREIPVVYVMVPPSATADATGRNVTGIEMDVPAERYLSLCGNGLGGKRVGIIYNPAKTGALVQEARQAAERLGITLVVRRADDPREAVRELSSLKGKVDTLWLLPDPTVVTRDTMESFALFSQQNRVPVVAFAAKYLQQGAVAAIEVDPADMGRQAGRMARRILDGASPQAETPEHPAKTRLKVNHSVAQHLGITLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39S93</accession>
    <name>Q39S93_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2663</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511798.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2663"/>
    <dbReference type="EnsemblBacteria" id="ABB32881">
        <property type="protein sequence ID" value="ABB32881"/>
        <property type="gene ID" value="Gmet_2663"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2663"/>
    <dbReference type="eggNOG" id="COG0457">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_665257_0_0_7"/>
    <dbReference type="OrthoDB" id="796596at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="SSF48452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="413" mass="46152" checksum="2997E11D1A941F5F" modified="2005-11-22" version="1">MKLNIGCGHTYLKGHLNIDVSGDSVADAIMEAHDLCLDTASVDEIVASQLMEHLGFFKGKYFLAECFRVLRPSGTLRLETPHLERSFEIFLAGDRTAREDALTWLYGAETAGMQHRFCFPLELLRELVAEAGFALMHHESFLYQDNRPSLRLILRKPADRKQHEFMAELRKRLVMQEIPAFEDELVMAGQEELLKRLADALQRDAAETMGLAVYSAEIVREFFTLKGKSDANAGKCRAVAARLAESRFQGALLAMLKARPEGAGRQGDAYREILRDGIAIISAVLAGKTVELPRDEGRPVTVFSEPLLKSLADKVFARGLKQFHLGEYREALDSFGESSRIFRDNPFVYWNSARIHGLHRNADAARLNYEMALAALDASPSEVKHAHRPALMAEMNGIPPWEPVSVIEKEGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-06-02" version="71" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SC8</accession>
    <name>Q39SC8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511834.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2627"/>
    <dbReference type="EnsemblBacteria" id="ABB32846">
        <property type="protein sequence ID" value="ABB32846"/>
        <property type="gene ID" value="Gmet_2627"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2627"/>
    <dbReference type="eggNOG" id="COG1073">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_039611_0_0_7"/>
    <dbReference type="OMA" id="WDRKNTA"/>
    <dbReference type="OrthoDB" id="1903504at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="SSF53474"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="430" mass="48844" checksum="478D617405FD1189" modified="2005-11-22" version="1">MRWFSKGIISLALAALLTGCVGNDQYRTSYEPCNVAQQGAECRKSSLEQNDEYLLGFVEFDDQGWFWDRKQANVLIDRLLEKDALESGLLMVVYVHGWRHNASFDDDNVASFRETLKRIYSYEHLASQSEGRPERKVAGIYVGWRGLSANVEPFRTLSFWDRKNTADKVGHGALTDLLVQLEEVQFSHLKVYDETKSRLAQTKLIIVGHSFGGEMVYSALSQILVDRFSGDAESPQTFGDLVILVNPAFEASRFTPLHDLAGVRKWYADGQLPLVAIFTSETDQATKTAFPVGRTLSTLFEKYRPDDGKQKQADRHAVGHFEPYRTHELRPRPEAEAAPPQATETPEKKVADLRTAKSLRQQWIDLSSRNGWSLDLGNARLTHLGKSLPRNPLYVVAVDKQIIDGHGDIWNERFIDFMRQFILFTTIVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39SI9</accession>
    <name>Q39SI9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513468.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2566"/>
    <dbReference type="EnsemblBacteria" id="ABB32785">
        <property type="protein sequence ID" value="ABB32785"/>
        <property type="gene ID" value="Gmet_2566"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2566"/>
    <dbReference type="eggNOG" id="ENOG502Z7U8">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_610679_0_0_7"/>
    <dbReference type="OMA" id="AYGYHGT"/>
    <dbReference type="OrthoDB" id="420136at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="435" mass="46932" checksum="C4F50A4CACC23B37" modified="2005-11-22" version="1">MTQYNPLKQIPATAGYGKGDVFVLFGELFGRGYANGIVDEAKKAGMTIIGATVGRRDNNGPLRPLTPEELAEAEANLGGKIINVPLEAGFDLEPAADGLTPADRLKGVKPDTVVETRLDMAAIEESRQKGLARFRENLALFAKDLDGLIPAGANVLIAHTMAGGIPRARTLMPILNRVFKGQGDRYLASGPFWKSDVGQLCSLSFDEVTADTFGALIAATAGLRSRVEGAGSRISYSAFGYHGCAVLIGGEYRWQSYTPYLQGWAKIRLEEVATKAWQEGVKATVYNSPEIQTNSSALFLGVEISLYPLLAALRKEGDGPAATAIWDACQGLLKEGETLDALLAKADAYLSSPVLNPFGTYEQWPHHNTAEQASLMLTVSDELMTMSADPKNVVCAELSKSVFQAVGRLMFDHSWSPQAPVVWLNHDTIARRLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ST9</accession>
    <name>Q39ST9_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ordered locus">Gmet_2460</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512440.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2460"/>
    <dbReference type="EnsemblBacteria" id="ABB32685">
        <property type="protein sequence ID" value="ABB32685"/>
        <property type="gene ID" value="Gmet_2460"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2460"/>
    <dbReference type="eggNOG" id="COG3614">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4251">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_114_62_7"/>
    <dbReference type="OMA" id="CYSISHE"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006189">
        <property type="entry name" value="CHASE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042240">
        <property type="entry name" value="CHASE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03924">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM01079">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50839">
        <property type="entry name" value="CHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="CHASE" evidence="9">
        <location>
            <begin position="87"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="397"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="352"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB32685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="606" mass="68196" checksum="AE2EECB979E54C86" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T12</accession>
    <name>Q39T12_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32612.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32612">
        <property type="protein sequence ID" value="ABB32612"/>
        <property type="gene ID" value="Gmet_2387"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2387"/>
    <dbReference type="HOGENOM" id="CLU_3043847_0_0_7"/>
    <dbReference type="OMA" id="IKQNTIH"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32612.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="51" mass="6144" checksum="6E9337B8A9C2454A" modified="2012-10-31" version="2">MLYFVKEKTIHTFPVSKRCTVQREKEQLRDTIPTDVEQCPYCMHSWPGEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T50</accession>
    <name>Q39T50_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Phospholipid/lipopolysaccharide-flipping ABC transporter MsbA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">msbA</name>
        <name evidence="12" type="ordered locus">Gmet_2349</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513271.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2349"/>
    <dbReference type="EnsemblBacteria" id="ABB32574">
        <property type="protein sequence ID" value="ABB32574"/>
        <property type="gene ID" value="Gmet_2349"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2349"/>
    <dbReference type="eggNOG" id="COG1132">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_84_3_7"/>
    <dbReference type="OMA" id="FNTLQMG"/>
    <dbReference type="OrthoDB" id="643917at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034040">
        <property type="term" value="F:ATPase-coupled lipid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011917">
        <property type="entry name" value="ABC_transpr_lipidA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="PTHR24221"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="SSF90123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02203">
        <property type="entry name" value="MsbA_lipidA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="1 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="19"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="335"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="367"/>
            <end position="374"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="571" mass="63225" checksum="007E4ACE3A9C43C3" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T60</accession>
    <name>Q39T60_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">acpP-4</name>
        <name evidence="2" type="ordered locus">Gmet_2339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4" key="3">
        <citation type="journal article" date="2011" name="Biochemistry" volume="50" first="1442" last="1453">
            <title>Solution structure of 4'-phosphopantetheine - GmACP3 from Geobacter metallireducens: a specialized acyl carrier protein with atypical structural features and a putative role in lipopolysaccharide biosynthesis.</title>
            <authorList>
                <person name="Ramelot T.A."/>
                <person name="Smola M.J."/>
                <person name="Lee H.W."/>
                <person name="Ciccosanti C."/>
                <person name="Hamilton K."/>
                <person name="Acton T.B."/>
                <person name="Xiao R."/>
                <person name="Everett J.K."/>
                <person name="Prestegard J.H."/>
                <person name="Montelione G.T."/>
                <person name="Kennedy M.A."/>
            </authorList>
            <dbReference type="PubMed" id="21235239"/>
            <dbReference type="DOI" id="10.1021/bi101932s"/>
        </citation>
        <scope>STRUCTURE BY NMR IN COMPLEX WITH PHOSPHOPANTETHEINE</scope>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513281.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="2LML">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=1-79"/>
    </dbReference>
    <dbReference type="PDBsum" id="2LML"/>
    <dbReference type="SMR" id="Q39T60"/>
    <dbReference type="STRING" id="269799.Gmet_2339"/>
    <dbReference type="DNASU" id="3739500"/>
    <dbReference type="EnsemblBacteria" id="ABB32564">
        <property type="protein sequence ID" value="ABB32564"/>
        <property type="gene ID" value="Gmet_2339"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2339"/>
    <dbReference type="eggNOG" id="COG0236">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_108696_20_2_7"/>
    <dbReference type="OMA" id="DWDSLNH"/>
    <dbReference type="OrthoDB" id="1943389at2"/>
    <dbReference type="EvolutionaryTrace" id="Q39T60"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="SSF47336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="2LML"/>
        </source>
    </evidence>
    <sequence length="79" mass="8941" checksum="BCBE9EBB9B6F6B7B" modified="2005-11-22" version="1">MPTLDALTPIFRQVFDDDSIVLTRETSANDIDAWDSLSHMNLIVSLEVHYKIKFALGELQKLKNVGDLADLVDKKLARK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="114" xmlns="http://uniprot.org/uniprot">
    <accession>Q39T99</accession>
    <name>SYL_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Leucine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Leucyl-tRNA synthetase</fullName>
            <shortName evidence="1">LeuRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">leuS</name>
        <name type="ordered locus">Gmet_2300</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514498.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39T99"/>
    <dbReference type="SMR" id="Q39T99"/>
    <dbReference type="STRING" id="269799.Gmet_2300"/>
    <dbReference type="PRIDE" id="Q39T99"/>
    <dbReference type="EnsemblBacteria" id="ABB32525">
        <property type="protein sequence ID" value="ABB32525"/>
        <property type="gene ID" value="Gmet_2300"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2300"/>
    <dbReference type="eggNOG" id="COG0495">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004427_0_0_7"/>
    <dbReference type="OMA" id="TFMVLAP"/>
    <dbReference type="OrthoDB" id="32262at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA editing activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00049_B">
        <property type="entry name" value="Leu_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002302">
        <property type="entry name" value="Leu-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025709">
        <property type="entry name" value="Leu_tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43740">
        <property type="entry name" value="PTHR43740"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13603">
        <property type="entry name" value="tRNA-synt_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00985">
        <property type="entry name" value="TRNASYNTHLEU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="SSF47323"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="SSF50677"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00396">
        <property type="entry name" value="leuS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000009346" description="Leucine--tRNA ligase">
        <location>
            <begin position="1"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'HIGH' region">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="'KMSKS' region">
        <location>
            <begin position="581"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="584"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00049"/>
        </source>
    </evidence>
    <sequence length="824" mass="93514" checksum="63EB85F98765DD2D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="86" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TA1</accession>
    <name>Q39TA1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA polymerase III, delta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">holA</name>
        <name evidence="3" type="ordered locus">Gmet_2298</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514500.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2298"/>
    <dbReference type="DNASU" id="3739326"/>
    <dbReference type="EnsemblBacteria" id="ABB32523">
        <property type="protein sequence ID" value="ABB32523"/>
        <property type="gene ID" value="Gmet_2298"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2298"/>
    <dbReference type="eggNOG" id="COG1466">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_044694_2_1_7"/>
    <dbReference type="OMA" id="EEPYYID"/>
    <dbReference type="OrthoDB" id="1199768at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009360">
        <property type="term" value="C:DNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010372">
        <property type="entry name" value="DNA_pol3_delta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005790">
        <property type="entry name" value="DNA_polIII_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06144">
        <property type="entry name" value="DNA_pol3_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="SSF48019"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01128">
        <property type="entry name" value="holA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DNA_pol3_delta" evidence="2">
        <location>
            <begin position="19"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="334" mass="37269" checksum="05ECF83D9CCC7461" modified="2005-11-22" version="1">MKIDEFNKALDRGEISPLYYFHGDEPHLMERAVKRLMDSAVPPDFRDFNLDVFYGNECKGDEVASVAQTLPMFADRRMVLVKRAGDLSAAALEILASCVADPPPTTCLVFMGEKVDQRKKFFQEMKKKGELVECKRPYENQLGAFIREEAKGLGKRVEPAAAEMLVYLVGNNLGELSTQLEKVALYVGQRETISVEDVRGIVSDTKVESVFDLTNALGERNVVKALRSLATILRDGEAPLMLLAMIARHFRQLWRVRDLMAQKVPQQDISRLAGINPYFIKGVMAQARNFSASELKKVFEGLYATDLALKGGGAKRPTLTLEKLVMDVCGMGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TE9</accession>
    <name>Q39TE9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011366002.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2248"/>
    <dbReference type="EnsemblBacteria" id="ABB32475">
        <property type="protein sequence ID" value="ABB32475"/>
        <property type="gene ID" value="Gmet_2248"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2248"/>
    <dbReference type="eggNOG" id="COG3203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016532_0_0_7"/>
    <dbReference type="OMA" id="GRHTVYW"/>
    <dbReference type="OrthoDB" id="227881at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010727">
        <property type="entry name" value="DUF1302"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06980">
        <property type="entry name" value="DUF1302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223499" evidence="1">
        <location>
            <begin position="35"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="544" mass="59171" checksum="A56299D20A887C55" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TF3</accession>
    <name>Q39TF3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Exporter, RND superfamily, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ordered locus">Gmet_2244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2244"/>
    <dbReference type="EnsemblBacteria" id="ABB32471">
        <property type="protein sequence ID" value="ABB32471"/>
        <property type="gene ID" value="Gmet_2244"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2244"/>
    <dbReference type="eggNOG" id="COG1033">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008861_4_0_7"/>
    <dbReference type="OMA" id="LHFVSHF"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004869">
        <property type="entry name" value="MMPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03176">
        <property type="entry name" value="MMPL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="668"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="736"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="771"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="7">
        <location>
            <begin position="278"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="ABB32471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="831" mass="91419" checksum="F89D6265B47C21E8" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TF6</accession>
    <name>Q39TF6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcriptional regulator, TetR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_2241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB32468">
        <property type="protein sequence ID" value="ABB32468"/>
        <property type="gene ID" value="Gmet_2241"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2241"/>
    <dbReference type="eggNOG" id="COG1309">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_069356_12_4_7"/>
    <dbReference type="OrthoDB" id="1437290at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001647">
        <property type="entry name" value="HTH_TetR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041490">
        <property type="entry name" value="KstR2_TetR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036271">
        <property type="entry name" value="Tet_transcr_reg_TetR-rel_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17932">
        <property type="entry name" value="TetR_C_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00440">
        <property type="entry name" value="TetR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00455">
        <property type="entry name" value="HTHTETR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48498">
        <property type="entry name" value="SSF48498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50977">
        <property type="entry name" value="HTH_TETR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH tetR-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="H-T-H motif" evidence="4">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="198" mass="22609" checksum="98E76BF6F16B6112" modified="2005-11-22" version="1">MSAKRHCSVDFLTYESERDNGKIECSTYDKLIKTAIMVMSEVGYKGMSIGILADMVGISKSTVIHYFKSKEGILLAVMENFLPAYIDEFKPVLNNKSLDGVTKLNKFVHFHMKMVAERKDVLSINIKDGKFLTGKSRTVYQQQQRLYGQQVVRIIQQIQSEETNLFKDLDPHVTAKAIMGMCNHACVWYKKNDILTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="121" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TH4</accession>
    <name>Q39TH4_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sigma 54-dependent transcriptional regulator, GAF domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_2223</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2223"/>
    <dbReference type="EnsemblBacteria" id="ABB32450">
        <property type="protein sequence ID" value="ABB32450"/>
        <property type="gene ID" value="Gmet_2223"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2223"/>
    <dbReference type="eggNOG" id="COG2203">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3604">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_8_11_7"/>
    <dbReference type="OMA" id="IKSIMFI"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeobox-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002197">
        <property type="entry name" value="HTH_Fis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025944">
        <property type="entry name" value="Sigma_54_int_dom_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02954">
        <property type="entry name" value="HTH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="SSF46689"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00688">
        <property type="entry name" value="SIGMA54_INTERACT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="6">
        <location>
            <begin position="244"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="556" mass="62093" checksum="F54174C8D8DC2A68" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="83" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TI0</accession>
    <name>Q39TI0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Oxidoreductase, short-chain dehydrogenase/reductase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_2217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365973.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2217"/>
    <dbReference type="EnsemblBacteria" id="ABB32444">
        <property type="protein sequence ID" value="ABB32444"/>
        <property type="gene ID" value="Gmet_2217"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2217"/>
    <dbReference type="eggNOG" id="COG1028">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010194_1_0_7"/>
    <dbReference type="OMA" id="PYDDFPE"/>
    <dbReference type="OrthoDB" id="1356861at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="258" mass="27032" checksum="26842CFA03856B58" modified="2005-11-22" version="1">MGRVEGKVAIVTGAASGLGAASARLLAREGARVVITDINVKDGQALANSLGEGAIFLRHDVSDEAQWVAIIEQTLSRFGRLDILVNNAGVVVVADVEHTTVEDWRFVNAVGTDGTFFGCKHAIPAMRRSGGGSIVNLSSLAGIGGYPLVFAYSASKGAIRAMTKSVAVHCAQNKYNIRCNSIHPGGILTPLVEGFIKSAVGTADASMDKARDLFSKLGEPDDVAYMVLYLASDESKFVSGSEFIIDNTATITEGVVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TL5</accession>
    <name>Q39TL5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SAM-dependent methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_2180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2180"/>
    <dbReference type="EnsemblBacteria" id="ABB32409">
        <property type="protein sequence ID" value="ABB32409"/>
        <property type="gene ID" value="Gmet_2180"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2180"/>
    <dbReference type="eggNOG" id="COG4627">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_116761_0_0_7"/>
    <dbReference type="OMA" id="FYERYLC"/>
    <dbReference type="OrthoDB" id="1515497at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="SSF53335"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransf_11" evidence="1">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="209" mass="24598" checksum="23439BEA567DA976" modified="2005-11-22" version="1">MLLYFDLKGLIMHDKTGVMKTINKKPSVIIECGCGESKRMADSIAIDIINMDGVDIVADLNKGFPFFDDNSVDGIVSHHFLEHLTSIDLFFKESYRILKKGGKFSGTVPHFSNPYFYSDYTHKTQFGLYSFSYLSKKQFFKRTVPVFYNDLDFEIIKLEIVFYSIFNSRKFPKRIVQKIVNRSKWTQEFYEECFCFMFPAFEIKFELQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="61" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TR8</accession>
    <name>Q39TR8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">p-cresol transport outer membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pcmK</name>
        <name evidence="1" type="ordered locus">Gmet_2127</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513078.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2127"/>
    <dbReference type="EnsemblBacteria" id="ABB32356">
        <property type="protein sequence ID" value="ABB32356"/>
        <property type="gene ID" value="Gmet_2127"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2127"/>
    <dbReference type="eggNOG" id="COG4313">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_066206_2_0_7"/>
    <dbReference type="OMA" id="MPAPRWE"/>
    <dbReference type="OrthoDB" id="1322015at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025737">
        <property type="entry name" value="Phenol_MetA_deg_put"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13557">
        <property type="entry name" value="Phenol_MetA_deg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB32356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="307" mass="33491" checksum="B9B785DE35E00167" modified="2005-11-22" version="1">MNLSKSLILSICLTTIVFIHSGAWAFNSSSFNGTADFYAGAAPPPGLHLIDYNVFMDIKKIENKGQGLVDGKGTLTAIAFRPIYVSEKGLFGGNFLMHSIIPLLSVEADVKANTPGGQITVQGHDGGLGDVYFGVGMAWHTPVWHWLTVLDVITPTGSFDPNKPVNAGNNAFIIEPVVAVTGMFPNGMEVNAKFMYSYHTKNSDYVEAGTGIKGYQTGQAFHMDYNVNYAVTKDLKLGVTGWLWQGLENDRIGGQKRADTKDFEFSMGPAARYQNGKFAVIGKYVLPVAAENRIEANQLWIDLVYSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TS6</accession>
    <name>Q39TS6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Menaquinol oxidoreductase complex, cytochrome b subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">pcmC</name>
        <name evidence="3" type="ordered locus">Gmet_2119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513086.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_2119"/>
    <dbReference type="EnsemblBacteria" id="ABB32348">
        <property type="protein sequence ID" value="ABB32348"/>
        <property type="gene ID" value="Gmet_2119"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2119"/>
    <dbReference type="eggNOG" id="COG1290">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_031114_0_1_7"/>
    <dbReference type="OMA" id="RWSAHAM"/>
    <dbReference type="OrthoDB" id="1339825at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.810.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005797">
        <property type="entry name" value="Cyt_b/b6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027387">
        <property type="entry name" value="Cytb/b6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016174">
        <property type="entry name" value="Di-haem_cyt_TM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00033">
        <property type="entry name" value="Cytochrome_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81342">
        <property type="entry name" value="SSF81342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51002">
        <property type="entry name" value="CYTB_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="CYTB_NTER" evidence="2">
        <location>
            <begin position="1"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB32348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="247" mass="28042" checksum="B10587591161C3D5" modified="2005-11-22" version="1">MSESAYSITEAIRQLPRNIKASISRRGEGTVEQEQAAAVFGNMFLHLHPVRVHVNSLRAGYTFGLGLISFYLFLILVASGLLLMFYYTPSTELAYRNMKDLEYVVTFGVILRNVHRWSAHAMVAFVFLHMCRVFYTGSYKAPREFNWVIGVFLLLVTLFLSFTGYLLPWDQLAFWAVTVGSNIAGYMPVLGDYIRFLMLGGNEVGQMALLRFYVLHVVALPLLAATLLGVHFWRIRKDGGLSRPRND</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-10-29" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39TV7</accession>
    <name>BAMA_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase</fullName>
            <shortName evidence="4">6-OCH-CoA hydrolase</shortName>
            <ecNumber evidence="2">3.7.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">6-oxocyclohex-1-ene-1-carbonyl-CoA hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">bamA</name>
        <name type="ordered locus">Gmet_2088</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2005" name="Mol. Microbiol." volume="58" first="1238" last="1252">
            <title>Gene clusters involved in anaerobic benzoate degradation of Geobacter metallireducens.</title>
            <authorList>
                <person name="Wischgoll S."/>
                <person name="Heintz D."/>
                <person name="Peters F."/>
                <person name="Erxleben A."/>
                <person name="Sarnighausen E."/>
                <person name="Reski R."/>
                <person name="Van Dorsselaer A."/>
                <person name="Boll M."/>
            </authorList>
            <dbReference type="PubMed" id="16313613"/>
            <dbReference type="DOI" id="10.1111/j.1365-2958.2005.04909.x"/>
        </citation>
        <scope>INDUCTION</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference key="3">
        <citation type="journal article" date="2008" name="Environ. Microbiol." volume="10" first="1547" last="1556">
            <title>6-Oxocyclohex-1-ene-1-carbonyl-coenzyme A hydrolases from obligately anaerobic bacteria: characterization and identification of its gene as a functional marker for aromatic compounds degrading anaerobes.</title>
            <authorList>
                <person name="Kuntze K."/>
                <person name="Shinoda Y."/>
                <person name="Moutakki H."/>
                <person name="McInerney M.J."/>
                <person name="Vogt C."/>
                <person name="Richnow H.-H."/>
                <person name="Boll M."/>
            </authorList>
            <dbReference type="PubMed" id="18312395"/>
            <dbReference type="DOI" id="10.1111/j.1462-2920.2008.01570.x"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBUNIT</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the central benzoyl-CoA catabolism. Catalyzes the addition of one molecule of water to the double bond and the hydrolytic cleavage of C-C bond in the alicyclic ring, 6-oxocyclohex-1-ene-1-carbonyl-CoA (6-OCH-CoA) to yield 3-hydroxypimelyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>6-oxocyclohex-1-ene-1-carbonyl-CoA + 2 H2O = 3-hydroxy-6-carboxyhexanoyl-CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:39651"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57343"/>
            <dbReference type="ChEBI" id="CHEBI:76526"/>
            <dbReference type="EC" id="3.7.1.21"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="2">70 uM for 6-OCH-CoA</KM>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="5">Aromatic compound metabolism; benzoyl-CoA degradation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homohexamer.</text>
    </comment>
    <comment type="induction">
        <text evidence="1">By benzoate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.21" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514578.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39TV7"/>
    <dbReference type="SMR" id="Q39TV7"/>
    <dbReference type="STRING" id="269799.Gmet_2088"/>
    <dbReference type="EnsemblBacteria" id="ABB32317">
        <property type="protein sequence ID" value="ABB32317"/>
        <property type="gene ID" value="Gmet_2088"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_2088"/>
    <dbReference type="eggNOG" id="COG1024">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_729117_0_0_7"/>
    <dbReference type="OMA" id="AILGCDK"/>
    <dbReference type="OrthoDB" id="1275789at2"/>
    <dbReference type="UniPathway" id="UPA00739"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018807">
        <property type="term" value="F:6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016823">
        <property type="term" value="F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901788">
        <property type="term" value="P:benzoyl-CoA catabolic process"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017613">
        <property type="entry name" value="Dearomat_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="SSF52096"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03200">
        <property type="entry name" value="dearomat_oah"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000430863" description="6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase">
        <location>
            <begin position="1"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000269" key="1">
        <source>
            <dbReference type="PubMed" id="16313613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="2">
        <source>
            <dbReference type="PubMed" id="18312395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="3">
        <source>
            <dbReference type="PubMed" id="16313613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="18312395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="5"/>
    <sequence length="381" mass="41952" checksum="0ACE5FECC5F587BB" modified="2005-11-22" version="1">MARTDEIIARTAPGHLNDHNLIDREVESLCDGMVKYEKRPAKRHDGSVAEGIYNAWIILDNPKQYNSYTTDMVKAIILAFRRASVDRSVNAVVFTGVGDKAFCTGGNTKEYAEYYAGNPQEYRQYMRLFNDMVSAILGCDKAVISRVNGMRIGGGQEIGMACDFSIAQDLANFGQAGPKHGSAAIGGATDFLPLMVGCEQAMVSGTLCEPFSAHKAARLGIICDVVPALKVGGKFVANPTVVTDRYLDEYGRVVHGEFKAGAAFKEGQGQIKEGEIDLSLLDEKVESLCTKLLETFPECMTKSLEELRKPKLHAWNLNKENSRAWLALNMMNEARTGFRAFNEGTKETGREIDFVKLRQGLAKGTPWTEELIESLMPTAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="88" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U86</accession>
    <name>Q39U86_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chromosome segregation and condensation protein ScpA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">scpA</name>
        <name evidence="2" type="ordered locus">Gmet_1959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511885.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1959"/>
    <dbReference type="DNASU" id="3740139"/>
    <dbReference type="EnsemblBacteria" id="ABB32188">
        <property type="protein sequence ID" value="ABB32188"/>
        <property type="gene ID" value="Gmet_1959"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1959"/>
    <dbReference type="eggNOG" id="COG1354">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038686_3_2_7"/>
    <dbReference type="OMA" id="YLVMAAM"/>
    <dbReference type="OrthoDB" id="959677at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01805">
        <property type="entry name" value="ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003768">
        <property type="entry name" value="ScpA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33969">
        <property type="entry name" value="PTHR33969"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02616">
        <property type="entry name" value="SMC_ScpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="266" mass="30396" checksum="60E6AFBAEE878692" modified="2005-11-22" version="1">MSNGGNLDLYQDEESPSYTVKLEVFEGPLDLLLHLIRKNEVDIYDIPLSTITKEYLEYIKMMKELNLEIAGEFLVMASTLIQIKSKTLLPTPVDEDAPEEEEEDPRAELVRRLLEYQKYKEAAVSLTGRDLLGRDTYARSFISPELAEMLPEEEPVEVELFELIEAFRKVLDRVSEESFHEVGAESITIAERINEILSLLEGKESLLFDELFPEHFNRDFLIATFLAVLELCKLKMVKVVQANRYGSIWIQPAVMDGEGSLVDAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39U96</accession>
    <name>Q39U96_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-export membrane protein SecG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="primary">secG</name>
        <name evidence="12" type="ordered locus">Gmet_1949</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="12 13" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in protein export. Participates in an early event of protein translocation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SecG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1949"/>
    <dbReference type="EnsemblBacteria" id="ABB32178">
        <property type="protein sequence ID" value="ABB32178"/>
        <property type="gene ID" value="Gmet_1949"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1949"/>
    <dbReference type="eggNOG" id="COG1314">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_094156_2_1_7"/>
    <dbReference type="OMA" id="MYEVLMV"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004692">
        <property type="entry name" value="SecG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34182">
        <property type="entry name" value="PTHR34182"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03840">
        <property type="entry name" value="SecG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01651">
        <property type="entry name" value="SECGEXPORT"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00810">
        <property type="entry name" value="secG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="78"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="ABB32178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="131" mass="13186" checksum="3E69DC4CD17AE12D" modified="2005-11-22" version="1">MTILLTILHILVCIALIAIVLLQSGKGAEMGASFGAGGSQSVFGAGGGTTFLSKLTTGAAIIFMLTSLTLAYLSGQSETSSIMPKGTVAPSPRKTAAPPTTQPTGTPQAPVQSTPTPQPSQRSSESAPQTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="97" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UC6</accession>
    <name>Q39UC6_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Response receiver-modulated cyclic diguanylate phosphodiesterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511924.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1919"/>
    <dbReference type="DNASU" id="3738103"/>
    <dbReference type="EnsemblBacteria" id="ABB32148">
        <property type="protein sequence ID" value="ABB32148"/>
        <property type="gene ID" value="Gmet_1919"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1919"/>
    <dbReference type="eggNOG" id="COG3437">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_92_10_7"/>
    <dbReference type="OMA" id="DHHEMAF"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037522">
        <property type="entry name" value="HD_GYP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51832">
        <property type="entry name" value="HD_GYP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="3">
        <location>
            <begin position="4"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="HD-GYP" evidence="4">
        <location>
            <begin position="152"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB32148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="350" mass="39562" checksum="4D06A071EF9B332A" modified="2005-11-22" version="1">MLPTILTVDDEEMIRDLMVTALSREGYRCFQAGSAEEARSVLQNNKIDLAILDIMMPGLSGDDFLKELKVLSPETVVLMVTALSDTETAMKCIHLGAYDYILKPFDIDRVLLTIHNALEKQRLLAENREYQANLEKKVDEQTRQIRMAMEDLNLAYNHTLTALVRALDAREKETGSHSERVMTYTLLLGEAMGVPEKDLSVMARGALLHDIGKVGISDNILLKPAKLDEREWMEMMRHPQLGYEILSGIKFLKGPAEIVFAHHERFDGSGYPKGLSRSGIPLGARIFSLVDTLDAMTSDRPYRKALPFEAVTSEVRRCRGTQFDPEIVDIFLSIPRERWEVVGKRHFIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UC8</accession>
    <name>Q39UC8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Response receiver sensor diguanylate cyclase, PAS domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1917</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511926.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1917"/>
    <dbReference type="EnsemblBacteria" id="ABB32146">
        <property type="protein sequence ID" value="ABB32146"/>
        <property type="gene ID" value="Gmet_1917"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1917"/>
    <dbReference type="eggNOG" id="COG2199">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2204">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_11_28_7"/>
    <dbReference type="OMA" id="TPIFYND"/>
    <dbReference type="OrthoDB" id="1635706at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01949">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000160">
        <property type="entry name" value="GGDEF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013656">
        <property type="entry name" value="PAS_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00990">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08448">
        <property type="entry name" value="PAS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00267">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="SSF52172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="SSF55073"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00254">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50887">
        <property type="entry name" value="GGDEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Response regulatory" evidence="2">
        <location>
            <begin position="6"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="3">
        <location>
            <begin position="146"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="4">
        <location>
            <begin position="212"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="GGDEF" evidence="5">
        <location>
            <begin position="293"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="1">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB32146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="419" mass="47223" checksum="63E6D6B285A8F07D" modified="2005-11-22" version="1">MNPPLRVLIIEDSEDDCFFLIRALKKEYEITHERVDTEDALRKALIGEKWDIVLSDYFMPQFDALAALLILQEMNLDLPFIIVSGRIGEIEAVKAMKAGAHDYIMKGDFTRLMPAIRRELREAVIREERRRAERDLREQLHFRQVLIDSIPAPIFFKNTNGVFLGCNKAFESFSGLVQNEVIGKTMADLASNSISERFVEADKELFQHGGTQIYESSISFADGALHDVIFYKATFNNIDNTLGGLVGTILDITERKQTEEKLRYMSTHDPLTGLYNRAYFQEELERLEQGRQFPVSIVVSDIDKLKYVNDSLGHAAGDDLITRAALILKGAFRAEDVVARIGGDEFAVLLPTADAVVVEEALTRVMSKIEASNTPDVSFALSMSFGAATASKGERLEETQKLADKRMYQHKFKKNHTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="117" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UD3</accession>
    <name>Q39UD3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 16">Aconitate hydratase B</fullName>
            <ecNumber evidence="5 16">4.2.1.3</ecNumber>
            <ecNumber evidence="6 16">4.2.1.99</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">2-methylisocitrate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="primary">acnB</name>
        <name evidence="22" type="ordered locus">Gmet_1912</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="22 23" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = 2-methyl-cis-aconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:17941"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="ChEBI" id="CHEBI:57872"/>
            <dbReference type="EC" id="4.2.1.99"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>citrate = D-threo-isocitrate</text>
            <dbReference type="Rhea" id="RHEA:10336"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="EC" id="4.2.1.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.3" evidence="5 16"/>
    <dbReference type="EC" id="4.2.1.99" evidence="6 16"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365887.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1912"/>
    <dbReference type="EnsemblBacteria" id="ABB32141">
        <property type="protein sequence ID" value="ABB32141"/>
        <property type="gene ID" value="Gmet_1912"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1912"/>
    <dbReference type="eggNOG" id="COG1049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016536_0_0_7"/>
    <dbReference type="OMA" id="QDTTGAM"/>
    <dbReference type="OrthoDB" id="32104at2"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00718"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00946"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047456">
        <property type="term" value="F:2-methylisocitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047780">
        <property type="term" value="F:citrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01576">
        <property type="entry name" value="AcnB_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004406">
        <property type="entry name" value="Aconitase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015933">
        <property type="entry name" value="Aconitase_B_HEAT-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036288">
        <property type="entry name" value="Aconitase_B_HEAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015929">
        <property type="entry name" value="Aconitase_B_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06434">
        <property type="entry name" value="Aconitase_2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11791">
        <property type="entry name" value="Aconitase_B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036687">
        <property type="entry name" value="AcnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="SSF53732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74778">
        <property type="entry name" value="SSF74778"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00117">
        <property type="entry name" value="acnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12 17" id="KW-0408">Iron</keyword>
    <keyword evidence="13 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9 16" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Aconitase_B_N" evidence="21">
        <location>
            <begin position="4"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase_2_N" evidence="20">
        <location>
            <begin position="167"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase" evidence="19">
        <location>
            <begin position="461"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="18">
        <location>
            <begin position="233"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Substrate binding" evidence="18">
        <location>
            <begin position="403"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="703"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="762"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="784"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="789"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00019379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR036687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR036687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR036687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF06434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF11791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="ABB32141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="847" mass="91141" checksum="22B62FC749FA30B6" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="130" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UE2</accession>
    <name>Q39UE2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sulfate ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">cysA</name>
        <name evidence="7" type="ordered locus">Gmet_1903</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511941.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1903"/>
    <dbReference type="EnsemblBacteria" id="ABB32132">
        <property type="protein sequence ID" value="ABB32132"/>
        <property type="gene ID" value="Gmet_1903"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1903"/>
    <dbReference type="eggNOG" id="COG1118">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000604_1_1_7"/>
    <dbReference type="OMA" id="HLGWEIQ"/>
    <dbReference type="OrthoDB" id="1220708at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043190">
        <property type="term" value="C:ATP-binding cassette (ABC) transporter complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015419">
        <property type="term" value="F:ABC-type sulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102025">
        <property type="term" value="F:ABC-type thiosulfate transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03296">
        <property type="entry name" value="ABC_CysA_sulfate_importer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008995">
        <property type="entry name" value="Mo/tungstate-bd_C_term_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005666">
        <property type="entry name" value="Sulph_transpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024765">
        <property type="entry name" value="TOBE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12857">
        <property type="entry name" value="TOBE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50331">
        <property type="entry name" value="SSF50331"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00968">
        <property type="entry name" value="3a0106s01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0764">Sulfate transport</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="3"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="35"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB32132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="343" mass="38106" checksum="578B663057E530AE" modified="2005-11-22" version="1">MSIEIVSVNKAFGSFTALNDVNLTVPSGELTALLGPSGSGKTTLLRIIAGLETPDAGSIRFDGEETTDRHVRERQVGFVFQHYALFRHMTVAENVAFGLTVKPRKERPSKKEIRERVFELLRLVQLEGLADRYPSQLSGGQRQRVALARALAVEPKVLLLDEPFGALDAKVRVELRRWLRRLHDEIHVTSVFVTHDQEEALEVADRIVVMNKGRIEQVGTPAEVYDQPANPFVFDFLGSVNLFHCRAEQGQARAAAPELSVGYVRSHDIEVERTPTVAAVEAEVRHVQAVGPAVRVELLVRGTGKTVEAELSRDGAERLALGIGETVYARPRKMQRFVGDYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="98" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UF0</accession>
    <name>Q39UF0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Winged helix-turn-helix transcriptional regulator, MarR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511949.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1895"/>
    <dbReference type="EnsemblBacteria" id="ABB32124">
        <property type="protein sequence ID" value="ABB32124"/>
        <property type="gene ID" value="Gmet_1895"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1895"/>
    <dbReference type="eggNOG" id="COG1846">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_083287_18_7_7"/>
    <dbReference type="OMA" id="GWIQREQ"/>
    <dbReference type="OrthoDB" id="1744037at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000835">
        <property type="entry name" value="HTH_MarR-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01047">
        <property type="entry name" value="MarR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00598">
        <property type="entry name" value="HTHMARR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00347">
        <property type="entry name" value="HTH_MARR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50995">
        <property type="entry name" value="HTH_MARR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH marR-type" evidence="1">
        <location>
            <begin position="2"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="150" mass="17489" checksum="6F0EB3C459550014" modified="2005-11-22" version="1">MHENLCSKLNYLARLLLSKVNEETSHFGVTQGQLPVLCCLNEKEGQTQSELCKNIQVEQPTMANTLRRMERDGLIYRNTSEHDGRQSQIFISTQVRPVIEVLQAKRDEVISRMLREMSVEERDTFERLVDMAVKGLDDRHQQTERKKEDV</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-04-04" modified="2022-08-03" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UG0</accession>
    <name>PDXJ_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxine 5'-phosphate synthase</fullName>
            <shortName evidence="1">PNP synthase</shortName>
            <ecNumber evidence="1">2.6.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pdxJ</name>
        <name type="ordered locus">Gmet_1885</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = H(+) + 2 H2O + phosphate + pyridoxine 5'-phosphate</text>
            <dbReference type="Rhea" id="RHEA:15265"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="EC" id="2.6.99.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxine 5'-phosphate biosynthesis; pyridoxine 5'-phosphate from D-erythrose 4-phosphate: step 5/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homooctamer; tetramer of dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PNP synthase family.</text>
    </comment>
    <dbReference type="EC" id="2.6.99.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511959.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39UG0"/>
    <dbReference type="SMR" id="Q39UG0"/>
    <dbReference type="STRING" id="269799.Gmet_1885"/>
    <dbReference type="EnsemblBacteria" id="ABB32114">
        <property type="protein sequence ID" value="ABB32114"/>
        <property type="gene ID" value="Gmet_1885"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1885"/>
    <dbReference type="eggNOG" id="COG0854">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074563_0_0_7"/>
    <dbReference type="OMA" id="SNAGWDT"/>
    <dbReference type="OrthoDB" id="1159993at2"/>
    <dbReference type="UniPathway" id="UPA00244">
        <property type="reaction ID" value="UER00313"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033856">
        <property type="term" value="F:pyridoxine 5'-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00003">
        <property type="entry name" value="PNPsynthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00279">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004569">
        <property type="entry name" value="PyrdxlP_synth_PdxJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036130">
        <property type="entry name" value="Pyridoxine-5'_phos_synth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30456">
        <property type="entry name" value="PTHR30456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03740">
        <property type="entry name" value="PdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63892">
        <property type="entry name" value="SSF63892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00559">
        <property type="entry name" value="pdxJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000231808" description="Pyridoxine 5'-phosphate synthase">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="70"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="7"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="9"/>
            <end position="10"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>1-deoxy-D-xylulose 5-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57792"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="213"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>3-amino-2-oxopropyl phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:57279"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="1">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00279"/>
        </source>
    </evidence>
    <sequence length="239" mass="25688" checksum="C541B46CFAC7D14B" modified="2005-11-22" version="1">MAKLGVNIDHVATIRQARGGVEPDPVAAAALAELAGADGITIHLREDRRHIQDRDLKLLRQTVKTKLNLEMAATAEMVAIALSVKPDMCTLVPEKRQELTTEGGLDVRIAMQGIAEAVERLQNGGIAVSLFVDPDPDQVKASSKVGSDYIEIHTGAFADAKDWKSEQDELERIGNAIKLGAKLGLGINAGHGLNYTNIRKVAALGGIEEYNIGHSIISRAVLVGLDRAVRDMVDLIKYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UI3</accession>
    <name>Q39UI3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Type II secretion system protein PulN, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">pulN</name>
        <name evidence="2" type="ordered locus">Gmet_1862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511984.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1862"/>
    <dbReference type="EnsemblBacteria" id="ABB32091">
        <property type="protein sequence ID" value="ABB32091"/>
        <property type="gene ID" value="Gmet_1862"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1862"/>
    <dbReference type="eggNOG" id="COG3166">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1501440_0_0_7"/>
    <dbReference type="OMA" id="FTISCKV"/>
    <dbReference type="OrthoDB" id="1905540at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007813">
        <property type="entry name" value="PilN"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05137">
        <property type="entry name" value="PilN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB32091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="179" mass="19604" checksum="A9D09B7A497B534A" modified="2005-11-22" version="1">MDLKINLSTRYFIDTRKLNAALAAAVALLVLVLFFVVKGVATNAGQAKQLEGELAKLQERFATSAKGVTEQEYQGIIKKISVANGILKKRGLNWLLLLDQLESVVPDGVTLSSIEPKLKEGTLTLAGTAKEFRNLRTFVENLEGAPRFSDVFLQSQTEVKEGTDQRGVGFTVTCKVDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UP1</accession>
    <name>Q39UP1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Molybdopterin molybdenumtransferase</fullName>
            <ecNumber evidence="7">2.10.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">moeA-3</name>
        <name evidence="9" type="ordered locus">Gmet_1804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 7">Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenylyl-molybdopterin + H(+) + molybdate = AMP + H2O + Mo-molybdopterin</text>
            <dbReference type="Rhea" id="RHEA:35047"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:36264"/>
            <dbReference type="ChEBI" id="CHEBI:62727"/>
            <dbReference type="ChEBI" id="CHEBI:71302"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.10.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 7">Belongs to the MoeA family.</text>
    </comment>
    <dbReference type="EC" id="2.10.1.1" evidence="7"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB32033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512042.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1804"/>
    <dbReference type="EnsemblBacteria" id="ABB32033">
        <property type="protein sequence ID" value="ABB32033"/>
        <property type="gene ID" value="Gmet_1804"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1804"/>
    <dbReference type="eggNOG" id="COG0303">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_010186_7_0_7"/>
    <dbReference type="OMA" id="KMPKVAF"/>
    <dbReference type="OrthoDB" id="651103at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061599">
        <property type="term" value="F:molybdopterin molybdotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032324">
        <property type="term" value="P:molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00887">
        <property type="entry name" value="MoeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.980.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036425">
        <property type="entry name" value="MoaB/Mog-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001453">
        <property type="entry name" value="MoaB/Mog_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038987">
        <property type="entry name" value="MoeA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005111">
        <property type="entry name" value="MoeA_C_domain_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036688">
        <property type="entry name" value="MoeA_C_domain_IV_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005110">
        <property type="entry name" value="MoeA_linker/N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036135">
        <property type="entry name" value="MoeA_linker/N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10192">
        <property type="entry name" value="PTHR10192"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00994">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03454">
        <property type="entry name" value="MoeA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03453">
        <property type="entry name" value="MoeA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00852">
        <property type="entry name" value="MoCF_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53218">
        <property type="entry name" value="SSF53218"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63867">
        <property type="entry name" value="SSF63867"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63882">
        <property type="entry name" value="SSF63882"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00177">
        <property type="entry name" value="molyb_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0500">Molybdenum</keyword>
    <keyword evidence="6 7" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MoCF_biosynth" evidence="8">
        <location>
            <begin position="175"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB32033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="434" mass="46857" checksum="58497B51C093629D" modified="2005-11-22" version="1">MPGSEETLRIILDNITPLGVERVDLQSALGRVLARDVVAPWDLPLFDNSARDGFALRSADCTGEGTTLRITGFIPAGCNVSEPVLGGCAVRIMTGAPIPHNCDAVVPGEDTLETDGQVTVMAPVRRRQYIRFRGEDLTGGDLVLTEGTVIQAQEIGLLASFGQAVVPVYRKARVAVLSTGDELIELGEQPSNGRIINSNAQYLAAALREIGAEPILLCIGRDNRESLKEQLQTGLKADALITTAGVSAGARDLVRDVLVEVGVRQMLGKIEMKSGGPKAFGMKDGIPVFSLPGNPLSTMVTFEEFVRPGLLRLMGHRRTVRPNLKARLREDIRKEPGRVHCQSVRVEAENGRYMATTVGNHKACRLSTIQRANAIVILPEGPSVVAAGEEVEVHLLRGDLVLLEEPNLTAGCVPDDRVSEEGETFERRVRVATR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="81" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UU4</accession>
    <name>Q39UU4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoesterase</fullName>
            <ecNumber evidence="3">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1749</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the metallophosphoesterase superfamily. YfcE family.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="3"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513355.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1749"/>
    <dbReference type="EnsemblBacteria" id="ABB31980">
        <property type="protein sequence ID" value="ABB31980"/>
        <property type="gene ID" value="Gmet_1749"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1749"/>
    <dbReference type="eggNOG" id="COG0622">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_063749_2_0_7"/>
    <dbReference type="OMA" id="ICFGHSH"/>
    <dbReference type="OrthoDB" id="1355703at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110165">
        <property type="term" value="C:cellular anatomical entity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00841">
        <property type="entry name" value="MPP_YfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041802">
        <property type="entry name" value="MPP_YfcE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="PTHR11124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="SSF56300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallophos_2" evidence="4">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="160" mass="17277" checksum="6F0E5FFFAE6352CA" modified="2005-11-22" version="1">MKIAIFSDTHGNHTLLARAFDLAGDVDHIFHLGDDTDDAIFLELLCGKTVIKVLGNCDFSTDSPRESLLSLEGMKFLLTHGDRYGVKGGLDKLTTRAAEEKADAVFYGHTHVPTVTTIDGILYVNPGCLKRGFSKPSFALLSLENGTLSASIVPVTPLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UU7</accession>
    <name>Q39UU7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ABC transporter, periplasmic substrate-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1746"/>
    <dbReference type="EnsemblBacteria" id="ABB31977">
        <property type="protein sequence ID" value="ABB31977"/>
        <property type="gene ID" value="Gmet_1746"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1746"/>
    <dbReference type="eggNOG" id="COG2984">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_058196_2_0_7"/>
    <dbReference type="OMA" id="NMDSETP"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="CDD" id="cd06325">
        <property type="entry name" value="PBP1_ABC_unchar_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007487">
        <property type="entry name" value="ABC_transpt-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35271">
        <property type="entry name" value="PTHR35271"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04392">
        <property type="entry name" value="ABC_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223529" evidence="1">
        <location>
            <begin position="30"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="324" mass="34821" checksum="B4C5ECCECA12F3B4" modified="2005-11-22" version="1">MWQRTLILKRLIYILPVLIFAVCATPASAARKFVAAVLTSDMPRYKEAYRAFVKGLAAKGYGEGEVEFVTQTPNPDPISWANSVRKFSALDPDILVTFGAPATISATQEVLRMPIVFVDVYGPVETGISRSMTKAGGNLCGVSSKVPMTTLIKAMMAIRPVKTLGILYNSRERGSYVQMQEIKRLAAQQGFAVLEANVPVASGLDAALTHVLSKSDCLFVSESSVVNRGMDKVMHKAMRAKVPVISLAPDAAGKGALVSLEVSPTEQGQLAANHVAKILSGMKPGDLPILTPRKVDLVINLESAKSLDLQVPFRVLSLATKVIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="73" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UU9</accession>
    <name>Q39UU9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">omcI</name>
        <name evidence="2" type="ordered locus">Gmet_1744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1744"/>
    <dbReference type="EnsemblBacteria" id="ABB31975">
        <property type="protein sequence ID" value="ABB31975"/>
        <property type="gene ID" value="Gmet_1744"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1744"/>
    <dbReference type="eggNOG" id="COG3005">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045390_0_0_7"/>
    <dbReference type="OMA" id="ADLQCEA"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020015">
        <property type="entry name" value="Decahaem_cyt-c_DmsE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010177">
        <property type="entry name" value="Paired_CXXCH_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09699">
        <property type="entry name" value="Paired_CXXCH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03508">
        <property type="entry name" value="decahem_SO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01905">
        <property type="entry name" value="paired_CXXCH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Paired_CXXCH_1" evidence="1">
        <location>
            <begin position="165"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="1">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Paired_CXXCH_1" evidence="1">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="337" mass="37135" checksum="3E1097FCB245C071" modified="2005-11-22" version="1">MNMLNTISGIFTAAVVTTGALLLSSCAELKQDRPLLPVREYERMIVGRLDAEYVGTDNCVSKCHKHEKIADDFRHSLHGEQIKPETGLPLVNCESCHGPGSLAIEKLGDNVEENDEKKVKCDTSTFLDIHNLPTPAQSLICLKCHAAASSPTLAHWTGSVHALNDVGCFDCHKLHRSPRQKVTREETAELCYGCHTEIKAENSLFSHHPIREKKIACTDCHDPHGSVQPHLLKGSTPKELCTRCHMEKQGPFAFEHGDVTENCATCHSPHGSVNNHLLNAAMPFLCLQCHGGHVVTLMPNDPVDKRLFNNRCTDCHSQIHGTDIPAGANNNRGNFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39UV1</accession>
    <name>Q39UV1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513362.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1742"/>
    <dbReference type="EnsemblBacteria" id="ABB31973">
        <property type="protein sequence ID" value="ABB31973"/>
        <property type="gene ID" value="Gmet_1742"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1742"/>
    <dbReference type="HOGENOM" id="CLU_1756200_0_0_7"/>
    <dbReference type="OMA" id="TQYIYRH"/>
    <dbReference type="OrthoDB" id="1862220at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="145" mass="16904" checksum="EA849C94CFEAEAD1" modified="2005-11-22" version="1">MTDEHDERRPLGLVLLTGLYLFFFVVTVSTYGSPFPFLGRIYLGTVAKALIFVDSLVCLYLFLGLMKRQNMTWYLLICYNLFEVINTIVNLTFITPAELERVIGERIDQEALMVNNIASALAILLLTQYIYRHKHYFTNSRKYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-04-07" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VC5</accession>
    <name>Q39VC5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Thiamin biosynthesis sulfur carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">thiS-2</name>
        <name evidence="1" type="ordered locus">Gmet_1567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2008-04" db="PDB data bank">
            <title>Crystal structure of thiamine biosynthesis protein (ThiS) from Geobacter metallireducens.</title>
            <authorList>
                <person name="Forouhar F."/>
                <person name="Abashidze M."/>
                <person name="Seetharaman J."/>
                <person name="Mao L."/>
                <person name="Janjua H."/>
                <person name="Xiao R."/>
                <person name="Maglaqui M."/>
                <person name="Ciccosanti C."/>
                <person name="Foote E.L."/>
                <person name="Wang H."/>
                <person name="Everett J.K."/>
                <person name="Acton T.B."/>
                <person name="Montelione G.T."/>
                <person name="Tong L."/>
                <person name="Hunt J.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS)</scope>
    </reference>
    <reference evidence="3" key="3">
        <citation type="submission" date="2008-06" db="PDB data bank">
            <title>NMR Solution Structure of a Thiamine Biosynthesis Protein from Geobacter Metallireducens: Northeast Structural Genomics Consortium Target GmR137.</title>
            <authorList>
                <person name="Mani R."/>
                <person name="Wang H."/>
                <person name="Jiang M."/>
                <person name="Magliaqui M."/>
                <person name="Xiao R."/>
                <person name="Nair R."/>
                <person name="Baran M.C."/>
                <person name="Gurla S.V.T."/>
                <person name="Acton T.B."/>
                <person name="Rost B."/>
                <person name="Montelione G.T."/>
            </authorList>
        </citation>
        <scope>STRUCTURE BY NMR</scope>
    </reference>
    <reference evidence="1 2" key="4">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511498.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="PDB" id="2K5P">
        <property type="method" value="NMR"/>
        <property type="chains" value="A=1-70"/>
    </dbReference>
    <dbReference type="PDB" id="3CWI">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=1-70"/>
    </dbReference>
    <dbReference type="PDBsum" id="2K5P"/>
    <dbReference type="PDBsum" id="3CWI"/>
    <dbReference type="SMR" id="Q39VC5"/>
    <dbReference type="STRING" id="269799.Gmet_1567"/>
    <dbReference type="DNASU" id="3738504"/>
    <dbReference type="EnsemblBacteria" id="ABB31799">
        <property type="protein sequence ID" value="ABB31799"/>
        <property type="gene ID" value="Gmet_1567"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1567"/>
    <dbReference type="eggNOG" id="COG2104">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_174611_3_2_7"/>
    <dbReference type="OMA" id="PDMVSVQ"/>
    <dbReference type="OrthoDB" id="2084255at2"/>
    <dbReference type="EvolutionaryTrace" id="Q39VC5"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010035">
        <property type="entry name" value="Thi_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="SSF54285"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01683">
        <property type="entry name" value="thiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3 4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="2K5P"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3CWI"/>
        </source>
    </evidence>
    <sequence length="70" mass="7454" checksum="179E2F36A1387921" modified="2005-11-22" version="1">MNLTVNGKPSTVDGAESLNVTELLSALKVAQAEYVTVELNGEVLEREAFDATTVKDGDAVEFLYFMGGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VK2</accession>
    <name>Q39VK2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gmd-2</name>
        <name evidence="4" type="synonym">gmd</name>
        <name evidence="6" type="ordered locus">Gmet_1488</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004511579.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1488"/>
    <dbReference type="EnsemblBacteria" id="ABB31722">
        <property type="protein sequence ID" value="ABB31722"/>
        <property type="gene ID" value="Gmet_1488"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1488"/>
    <dbReference type="eggNOG" id="COG1089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_14_0_7"/>
    <dbReference type="OMA" id="FVKSSWQ"/>
    <dbReference type="OrthoDB" id="955232at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="5"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="349" mass="39458" checksum="EC8B18C5D0F22D46" modified="2005-11-22" version="1">MKKALITGITGQDGSYLAELLLQKGYEVHGMIRRSSSFNTGRINHIYRDPHEKDVRLFLHYGDLNDASSINTLLRIVQPDEIYNLGAQSHVRVSFDVPEYTGEVDALGAVRILEGIRETGLNTRFYQASSSELYGKVVETPQRESTPFYPRSPYGCAKAYAYYITQNYRESYDIYACNGILFNHESPRRGETFVTRKITRAAARIKLGLQNCLYLGNLDAKRDWGFAGDYVEAMWLMLQQEQADDYVIATGETYMVRTFAEKVFARLGMPLEWGGSGDREEGVDTATGKPLIRVDSKYFRPAEVDLLLGDPSKAKRVLGWQQQTSFDQLVAMMTDADLALAEREMRANG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VU5</accession>
    <name>Q39VU5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Type IV pilus inner membrane protein PilC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">pilC</name>
        <name evidence="9" type="ordered locus">Gmet_1395</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GSP F family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513113.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1395"/>
    <dbReference type="EnsemblBacteria" id="ABB31629">
        <property type="protein sequence ID" value="ABB31629"/>
        <property type="gene ID" value="Gmet_1395"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1395"/>
    <dbReference type="eggNOG" id="COG1459">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_035032_2_1_7"/>
    <dbReference type="OMA" id="TRQMATM"/>
    <dbReference type="OrthoDB" id="1268170at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.81.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003004">
        <property type="entry name" value="GspF/PilC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018076">
        <property type="entry name" value="T2SS_GspF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042094">
        <property type="entry name" value="T2SS_GspF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30012">
        <property type="entry name" value="PTHR30012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00482">
        <property type="entry name" value="T2SSF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00812">
        <property type="entry name" value="BCTERIALGSPF"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="70"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="T2SSF" evidence="8">
        <location>
            <begin position="273"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB31629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="405" mass="43152" checksum="B3D351AF65E90153" modified="2005-11-22" version="1">MPKFSWEARSRTGAAQKGVMEAASAAAVEAQLKKFGFGSISVKEEGKGLSMELKLPGFGKKVETKDLVIFTRQFATMIDSGLPLVQCLDILSSQQENATFKEVLIKVKETVEGGSTFADALSKHPKVFDQLFVNLVAAGEVGGILDTILNRLAAYIEKAMKLKKQIKGAMVYPATIMTIAIGVVAVILIFVIPTFAKMFADFGGELPGATKFVIALSNFVVKYILLIIGLIFAVVVAIKKYYATPNGKKTLDTLALKAPIAGPLIRKVSVARFTRTLGTLISSGVPIMDGLEIVAKTAGNKVVEEAVYKVRSSIAEGKTMAEPLQECGVFPPMVVQMISVGEATGAMDAMLSKIADFYDDEVDDAVSALTALMEPMLMVFLGTTVGGLVIAMYLPIFKLAGTVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="74" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VV1</accession>
    <name>Q39VV1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1389</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513119.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1389"/>
    <dbReference type="EnsemblBacteria" id="ABB31623">
        <property type="protein sequence ID" value="ABB31623"/>
        <property type="gene ID" value="Gmet_1389"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1389"/>
    <dbReference type="eggNOG" id="COG0392">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048072_3_1_7"/>
    <dbReference type="OMA" id="AGPWHFA"/>
    <dbReference type="OrthoDB" id="1819626at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022791">
        <property type="entry name" value="L-PG_synthase/AglD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03706">
        <property type="entry name" value="LPG_synthase_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00374">
        <property type="entry name" value="TIGR00374"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="336" mass="36373" checksum="D8A4C397D5417B70" modified="2005-11-22" version="1">MTALAGDKRLWLGIGVSIALLALLFRSVDPAELIRAFRGIQGIWLVPAVVFTFLSYLMRAVRWKYLLSPLKQTSFPNLVSATLIGYMANNLLPARLGELVRAYVLGEQEGIGTGAVVATLVIDRLADGFTVLLLLVTAVFTLRLPPGSEAAQQGLVAGGYITLGLYLAVVVFLVLLRRNTMGTIRLLERLLRPFPGKIAEKVIPFLGAFIDGARITPHWRERLALVASSLVIWGFAVFPIHCVLKAFGLNFPIPVSLFIMVLLVFAVMVPASPGFVGTYHAACVYGLLALGVPRGMALSVAIVIHGINFFPVIVVGLACLWRENLSLSALSKKAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="89" xmlns="http://uniprot.org/uniprot">
    <accession>Q39VX9</accession>
    <name>Q39VX9_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">2-oxoglutarate:ferredoxin oxidoreductase, ferredoxin subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">korD</name>
        <name evidence="5" type="ordered locus">Gmet_1361</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513147.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1361"/>
    <dbReference type="EnsemblBacteria" id="ABB31595">
        <property type="protein sequence ID" value="ABB31595"/>
        <property type="gene ID" value="Gmet_1361"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1361"/>
    <dbReference type="eggNOG" id="COG2768">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_139698_5_3_7"/>
    <dbReference type="OMA" id="ACMQCEL"/>
    <dbReference type="OrthoDB" id="1873445at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13187">
        <property type="entry name" value="Fer4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="64" mass="7281" checksum="54FE22F736FA9760" modified="2005-11-22" version="1">MEKKLPTIEIVEKYCKGCHICVEFCPTKVLEMKGFVVAVKNLEACIKCMQCELRCPDFAIKVTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="54" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W09</accession>
    <name>Q39W09_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_1330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1330"/>
    <dbReference type="EnsemblBacteria" id="ABB31565">
        <property type="protein sequence ID" value="ABB31565"/>
        <property type="gene ID" value="Gmet_1330"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1330"/>
    <dbReference type="eggNOG" id="ENOG5032SXY">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059692_1_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="372" mass="42677" checksum="C2E20464E29E984F" modified="2005-11-22" version="1">MVDMHDIVYILLFVFVAVSAFVSSLCQDKALKFILFSASTFFMSAIIAFRWEIGTDWNSYYEYFVGIKNGSGSSYDNHFDIGFYLLNFVIANINGNYTIFLIVTTVLSTVLVNYIIYKKSNNPHLGQLIFLGNYLPIHFMGSIRRSIAITFVFLFLIYSIQYKNKIKSYIIMMFAFAQHKTSIIGITKLIVPKKRFSVKVIIALIGAAYFINYIGLIDLILEKLLMITVGGPDIGLVKTIANYSGENYKLYSPENVNPQMQSLLSMIKKIIYLFFFTRGLARNSNSLDDISLNIYVIGIMIYTLFIGAMVIQVLSVYFLFMEVLLASRVYSKLRLYEKRVFLIYILVISYASYDSNLSVFPELFSPYRSVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="68" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W21</accession>
    <name>Q39W21_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_1317</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the HepT RNase toxin family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1317"/>
    <dbReference type="EnsemblBacteria" id="ABB31553">
        <property type="protein sequence ID" value="ABB31553"/>
        <property type="gene ID" value="Gmet_1317"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1317"/>
    <dbReference type="eggNOG" id="COG2445">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_142825_1_0_7"/>
    <dbReference type="OMA" id="FLAHDYE"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110001">
        <property type="term" value="C:toxin-antitoxin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008201">
        <property type="entry name" value="HepT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037038">
        <property type="entry name" value="HepT-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01934">
        <property type="entry name" value="DUF86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-1277">Toxin-antitoxin system</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="138" mass="15788" checksum="731D807CEFF7B459" modified="2005-11-22" version="1">MERIRQKIGRINEHLSIIRAIKDDCSRKFAVDPIYRGALLHYLYLLSDGCIVLAELVIKHKGLRLPQSYAESFDILGESKVLDEDFAYRFASIAGFRNFLAHDYEKIDQEVICGAIMNSLNDVDIFLQHIRKSMGLVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W27</accession>
    <name>Q39W27_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">GDP-mannose 4,6-dehydratase</fullName>
            <ecNumber evidence="3 4">4.2.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">GDP-D-mannose dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">gmd-1</name>
        <name evidence="4" type="synonym">gmd</name>
        <name evidence="6" type="ordered locus">Gmet_1311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>GDP-alpha-D-mannose = GDP-4-dehydro-alpha-D-rhamnose + H2O</text>
            <dbReference type="Rhea" id="RHEA:23820"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57964"/>
            <dbReference type="EC" id="4.2.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.47" evidence="3 4"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514786.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1311"/>
    <dbReference type="EnsemblBacteria" id="ABB31547">
        <property type="protein sequence ID" value="ABB31547"/>
        <property type="gene ID" value="Gmet_1311"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1311"/>
    <dbReference type="eggNOG" id="COG1089">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_007383_14_1_7"/>
    <dbReference type="OMA" id="TDCLYLG"/>
    <dbReference type="OrthoDB" id="955232at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008446">
        <property type="term" value="F:GDP-mannose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019673">
        <property type="term" value="P:GDP-mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00955">
        <property type="entry name" value="GDP_Man_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006368">
        <property type="entry name" value="GDP_Man_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43715">
        <property type="entry name" value="PTHR43715"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="SSF51735"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01472">
        <property type="entry name" value="gmd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-bd_dom" evidence="5">
        <location>
            <begin position="5"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="360" mass="41128" checksum="C7EAAAEFC88D4881" modified="2005-11-22" version="1">MKKALITGITGQDGSYLAELLLEKGYEVHGVKRRASLFNTDRIDHLYQDPHETGRRFVLHYGDMTDSTNLIRIIQSVQPDEIYNLAAQSHVAVSFETPEYTANADAIGPLRILEAIRILGLEKKTRFYQASTSELYGLVQEIPQKETTPFYPRSPYAVAKLYAYWITVNYRESYGIYGCNGILFNHESPVRGETFVTRKITRALARIKLGLQECLYLGNLDAKRDWGHARDYVEMQWLLMQQDEPEDWVIATGIQYSVRDFVNAAAEELGMKIAWQGAGVNETGTDHSGKVMVKVDPRYFRPTEVETLLGDAAKAREKLGWAPKISFRELVSEMVREDLRAAERDELVKKHGYKAFDHHE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="96" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W62</accession>
    <name>PYRG_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CTP synthase</fullName>
            <ecNumber evidence="1">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cytidine 5'-triphosphate synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Cytidine triphosphate synthetase</fullName>
            <shortName evidence="1">CTP synthetase</shortName>
            <shortName evidence="1">CTPS</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">pyrG</name>
        <name type="ordered locus">Gmet_1276</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O + L-glutamine + UTP = ADP + CTP + 2 H(+) + L-glutamate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutamine = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + NH4(+) + UTP = ADP + CTP + 2 H(+) + phosphate</text>
            <dbReference type="Rhea" id="RHEA:16597"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="1">Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CTP synthase family.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512091.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W62"/>
    <dbReference type="SMR" id="Q39W62"/>
    <dbReference type="STRING" id="269799.Gmet_1276"/>
    <dbReference type="EnsemblBacteria" id="ABB31512">
        <property type="protein sequence ID" value="ABB31512"/>
        <property type="gene ID" value="Gmet_1276"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1276"/>
    <dbReference type="eggNOG" id="COG0504">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_011675_5_0_7"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="783657at2"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01227">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="PTHR11550"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="SSF52317"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword id="KW-0436">Ligase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000266125" description="CTP synthase">
        <location>
            <begin position="1"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase type-1" evidence="1">
        <location>
            <begin position="292"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Amidoligase domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; for glutamine hydrolysis" evidence="1">
        <location>
            <position position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="15"/>
            <end position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="147"/>
            <end position="149"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="382"/>
            <end position="385"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="405"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01227"/>
        </source>
    </evidence>
    <sequence length="538" mass="59477" checksum="FDB8916706AF7AF5" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39W79</accession>
    <name>ILVD_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dihydroxy-acid dehydratase</fullName>
            <shortName evidence="1">DAD</shortName>
            <ecNumber evidence="1">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">ilvD</name>
        <name type="ordered locus">Gmet_1259</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="1">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="1">Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IlvD/Edd family.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512108.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39W79"/>
    <dbReference type="SMR" id="Q39W79"/>
    <dbReference type="STRING" id="269799.Gmet_1259"/>
    <dbReference type="PRIDE" id="Q39W79"/>
    <dbReference type="EnsemblBacteria" id="ABB31495">
        <property type="protein sequence ID" value="ABB31495"/>
        <property type="gene ID" value="Gmet_1259"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1259"/>
    <dbReference type="eggNOG" id="COG0129">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_014271_4_2_7"/>
    <dbReference type="OMA" id="TQGRNMA"/>
    <dbReference type="OrthoDB" id="193579at2"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="SSF143975"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_1000000985" description="Dihydroxy-acid dehydratase">
        <location>
            <begin position="1"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="78"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="1">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="1">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00012"/>
        </source>
    </evidence>
    <sequence length="553" mass="58483" checksum="61458FB0EC1FD44F" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WA2</accession>
    <name>Q39WA2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Peptide ABC transporter, membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_1236</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the binding-protein-dependent transport system permease family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512133.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1236"/>
    <dbReference type="EnsemblBacteria" id="ABB31472">
        <property type="protein sequence ID" value="ABB31472"/>
        <property type="gene ID" value="Gmet_1236"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1236"/>
    <dbReference type="eggNOG" id="COG1173">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028518_1_1_7"/>
    <dbReference type="OMA" id="VHMRESA"/>
    <dbReference type="OrthoDB" id="1734230at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06261">
        <property type="entry name" value="TM_PBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3720.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035906">
        <property type="entry name" value="MetI-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025966">
        <property type="entry name" value="OppC_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00528">
        <property type="entry name" value="BPD_transp_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12911">
        <property type="entry name" value="OppC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161098">
        <property type="entry name" value="SSF161098"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="82"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB31472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="284" mass="31248" checksum="4B77413A2CD9F89B" modified="2005-11-22" version="1">MAFRESWFHTVFWKRFRHNRFAMAGGCVVLLLFVVSLLAPYITPWDPHAIDAYHVLLPPSANHWFGTDELGRDVFTRVVYGARISLKVGFVSVGIAVAIGVVLGLVSGFYGGIIDTVIMRFVDIMLCFPTFFLILAVIAFLEPSIWYIMAIIGLTGWMGVARLVRAEVLSLRERDFILAARALGASDARIIFRHILPNALSPVLVSATLGVAGAILTESALSFLGIGVQPPTPSWGNILTSGKDYIEFGWWLSLFPGLAILVTVLAYNLLGEGIRDALDPRLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WN7</accession>
    <name>Q39WN7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable membrane transporter protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_1097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513753.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1097"/>
    <dbReference type="EnsemblBacteria" id="ABB31337">
        <property type="protein sequence ID" value="ABB31337"/>
        <property type="gene ID" value="Gmet_1097"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1097"/>
    <dbReference type="eggNOG" id="COG0730">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_045498_6_0_7"/>
    <dbReference type="OMA" id="FSATQMF"/>
    <dbReference type="OrthoDB" id="881796at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="263" mass="26804" checksum="6436B7650F49CCBE" modified="2005-11-22" version="1">MFLLAYLALGAFAGVLAGLLGVGGGIVIVPALTFLFTAQGLPAPYIAHLALGTSLATIIFTSVSSLRAHHGRGAVEWRVVRRISAGIVAGTLAGSWVAAQLSTRSLKVFFVVFLYYVAIQMLLNIRPKPSRQLPGTGGMLGVGGVIGAVSSLVGIGGGSLSVPFMVWCNISMHNAIGTSAAIGFPIALAGAAGYMANGLVVTSLPPWSVGFVYLPALAGIALASVITAPFGARLAHNLPVSGLKKIFALLLIVMGTKLLSGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="56" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WP3</accession>
    <name>Q39WP3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513747.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1091"/>
    <dbReference type="EnsemblBacteria" id="ABB31331">
        <property type="protein sequence ID" value="ABB31331"/>
        <property type="gene ID" value="Gmet_1091"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1091"/>
    <dbReference type="HOGENOM" id="CLU_2081437_0_0_7"/>
    <dbReference type="OMA" id="CCADETI"/>
    <dbReference type="OrthoDB" id="2093587at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="117" mass="12408" checksum="AC30B3A1F572ACFC" modified="2005-11-22" version="1">MNAMKTVILSHRVLAAALVVILLLLSTSGFGLALSLHLKDQTPSKHANCGCITADSDGGESGGPASEAFHGDFNPSCIAPLVMPAYAPPVENLHPFEPFRAPPQVFYDLFVPPQNHC</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-03" modified="2022-05-25" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WQ8</accession>
    <name>CHED1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable chemoreceptor glutamine deamidase CheD 1</fullName>
            <ecNumber evidence="1">3.5.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cheD1</name>
        <name type="ordered locus">Gmet_1076</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>H2O + L-glutaminyl-[protein] = L-glutamyl-[protein] + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16441"/>
            <dbReference type="Rhea" id="RHEA-COMP:10207"/>
            <dbReference type="Rhea" id="RHEA-COMP:10208"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29973"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="EC" id="3.5.1.44"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CheD family.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.44" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513732.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39WQ8"/>
    <dbReference type="SMR" id="Q39WQ8"/>
    <dbReference type="STRING" id="269799.Gmet_1076"/>
    <dbReference type="EnsemblBacteria" id="ABB31316">
        <property type="protein sequence ID" value="ABB31316"/>
        <property type="gene ID" value="Gmet_1076"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1076"/>
    <dbReference type="eggNOG" id="COG1871">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_087854_0_0_7"/>
    <dbReference type="OMA" id="MQAKIFG"/>
    <dbReference type="OrthoDB" id="1863047at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050568">
        <property type="term" value="F:protein-glutamine glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006935">
        <property type="term" value="P:chemotaxis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16352">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01440">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038592">
        <property type="entry name" value="CheD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005659">
        <property type="entry name" value="Chemorcpt_Glu_NH3ase_CheD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011324">
        <property type="entry name" value="Cytotoxic_necrot_fac-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35147">
        <property type="entry name" value="PTHR35147"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03975">
        <property type="entry name" value="CheD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64438">
        <property type="entry name" value="SSF64438"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0145">Chemotaxis</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000251033" description="Probable chemoreceptor glutamine deamidase CheD 1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01440"/>
        </source>
    </evidence>
    <sequence length="178" mass="19653" checksum="45F00ADF13F0456C" modified="2005-11-22" version="1">MHTGRYFAKNSYYDRTFNKQAVKILPGEYHATDSDTMIVTVLGSCVSVCIRDRLSGIGGMNHYMLPGEAGTDESPSPRYGTHAMELLIDHLIQLGGRLPYLEAKVFGAGRVINGVTDVGERNAEFALRYLEEREIPVTAVDVGDIYPRKVYFAPATGRAFVRQIRTGSIDSLFIGESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="72" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X15</accession>
    <name>Q39X15_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Type IV pilus assembly protein PilY1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">pilY1-2</name>
        <name evidence="6" type="ordered locus">Gmet_0967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PilY1 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365750.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0967"/>
    <dbReference type="EnsemblBacteria" id="ABB31209">
        <property type="protein sequence ID" value="ABB31209"/>
        <property type="gene ID" value="Gmet_0967"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0967"/>
    <dbReference type="eggNOG" id="COG2304">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3419">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004773_0_0_7"/>
    <dbReference type="OMA" id="NQGLVHM"/>
    <dbReference type="OrthoDB" id="165468at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009289">
        <property type="term" value="C:pilus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008707">
        <property type="entry name" value="PilC_beta_prop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_supfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05567">
        <property type="entry name" value="Neisseria_PilC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="SSF50998"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="SSF53300"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0281">Fimbrium</keyword>
    <keyword evidence="2" id="KW-1029">Fimbrium biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223375" evidence="4">
        <location>
            <begin position="33"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="Neisseria_PilC" evidence="5">
        <location>
            <begin position="568"/>
            <end position="870"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="1030" mass="110931" checksum="3ADF46987FA8DD4D" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X23</accession>
    <name>Q39X23_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Prepilin leader peptidase/N-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
            <ecNumber evidence="10">3.4.23.43</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="primary">pilD</name>
        <name evidence="14" type="ordered locus">Gmet_0959</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an essential role in type IV pili and type II pseudopili formation by proteolytically removing the leader sequence from substrate proteins and subsequently monomethylating the alpha-amino group of the newly exposed N-terminal phenylalanine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Typically cleaves a -Gly-|-Phe- bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine.</text>
            <dbReference type="EC" id="3.4.23.43"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cell membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the peptidase A24 family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EC" id="3.4.23.43" evidence="10"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514353.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0959"/>
    <dbReference type="MEROPS" id="A24.019"/>
    <dbReference type="DNASU" id="3738200"/>
    <dbReference type="EnsemblBacteria" id="ABB31201">
        <property type="protein sequence ID" value="ABB31201"/>
        <property type="gene ID" value="Gmet_0959"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0959"/>
    <dbReference type="eggNOG" id="COG1989">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_057101_0_1_7"/>
    <dbReference type="OMA" id="VFWLFKL"/>
    <dbReference type="OrthoDB" id="2046608at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010627">
        <property type="entry name" value="Pept_A24A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014032">
        <property type="entry name" value="Peptidase_A24A_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000045">
        <property type="entry name" value="Prepilin_IV_endopep_pep"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06750">
        <property type="entry name" value="DiS_P_DiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01478">
        <property type="entry name" value="Peptidase_A24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00864">
        <property type="entry name" value="PREPILNPTASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DiS_P_DiS" evidence="13">
        <location>
            <begin position="13"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase_A24" evidence="12">
        <location>
            <begin position="107"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB31201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="259" mass="27783" checksum="A2826E33AC2C9635" modified="2005-11-22" version="1">MSPVVIFALFSFLLGAAVGSFLNVCIYRLPAGESVVSPPSRCPACGARIRPWHNIPILGWLILRGKCRDCGAPISPRYPFVELLNGLLTLALFLKFGPSPTFLVLFVFCSALVAVTFIDLDHQLIPDVISLPGIVVGFACSFALPWLGWKSSLIGIVAGGGSLLSVARLYELLTKKEGMGGGDIKLLAMMGAFLGWRSVPFIIFASSLIGSVIGVTLMLVQKKDSKLAIPFGPFLATGAVLYIFFGKTIITWYLTLGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="87" xmlns="http://uniprot.org/uniprot">
    <accession>Q39X86</accession>
    <name>Q39X86_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="1">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="primary">yggS</name>
        <name evidence="5" type="ordered locus">Gmet_0896</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513043.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0896"/>
    <dbReference type="EnsemblBacteria" id="ABB31138">
        <property type="protein sequence ID" value="ABB31138"/>
        <property type="gene ID" value="Gmet_0896"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0896"/>
    <dbReference type="eggNOG" id="COG0325">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_059988_1_0_7"/>
    <dbReference type="OMA" id="IEWHMIG"/>
    <dbReference type="OrthoDB" id="1423012at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PTHR10146"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="SSF51419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00044">
        <property type="entry name" value="TIGR00044"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ala_racemase_N" evidence="4">
        <location>
            <begin position="6"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="1 2">
        <location>
            <position position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_02087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="231" mass="25312" checksum="46259A141DE528DD" modified="2005-11-22" version="1">MTIASNLIHLQERIATVARRAGRDPESVRLVAVSKTKPAEAVEDAARAGQRLFGENYVQEFTAKAGEVREPVEWHFIGALQSNKVRQIAGLVTMIHSVDRLSLAQEIERQWAKLDTTCDVLIQVNIAGEATKSGTTAGELLTLVREVALLPHLRVRGLMTMPPFFDDPEGARPYFRELKRLAGVVAAAGIPGVVMDELSMGMSGDFEAAVEEGATLVRIGTSLFGEREYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XG8</accession>
    <name>Q39XG8_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein QmcA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0814</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514401.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0814"/>
    <dbReference type="EnsemblBacteria" id="ABB31056">
        <property type="protein sequence ID" value="ABB31056"/>
        <property type="gene ID" value="Gmet_0814"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0814"/>
    <dbReference type="eggNOG" id="COG0330">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_024949_3_3_7"/>
    <dbReference type="OMA" id="NAVLYFR"/>
    <dbReference type="OrthoDB" id="1213601at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018080">
        <property type="entry name" value="Band_7/stomatin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_HflKC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="PTHR10264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="SSF117892"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01270">
        <property type="entry name" value="BAND_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="PHB" evidence="4">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB31056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="257" mass="28831" checksum="34F891A829A374DB" modified="2005-11-22" version="1">MFDIFNYVPVVFILILLIMFAASAIRVLPEYERGVLFRLGRLAGVRGPGLFFIIPGIDKLIRVSLRIVALDVPPQDVITHDNVTVKVSAVICFRVMEPQKAIVEVENYLYATSQLAQTTLRSVLGQVELDELLANREKINKELQEILDRHTGPWGVKVTAVEVKNIDLPQEMLRAIAKQAEAERERRAKVIHADGEFQASEKLAQAAKVLAAEPTSLQLRYLQTLTEIAAEKNSTTIFPIPIDLIKMFLEKMGDRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="82" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XL5</accession>
    <name>Q39XL5_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513512.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0767"/>
    <dbReference type="EnsemblBacteria" id="ABB31009">
        <property type="protein sequence ID" value="ABB31009"/>
        <property type="gene ID" value="Gmet_0767"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0767"/>
    <dbReference type="eggNOG" id="COG0433">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_028164_1_1_7"/>
    <dbReference type="OMA" id="TTEYGNI"/>
    <dbReference type="OrthoDB" id="600220at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033186">
        <property type="entry name" value="HerA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05872">
        <property type="entry name" value="DUF853"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB31009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="482" mass="51374" checksum="3CB95FA2422EE5AE" modified="2005-11-22" version="1">MGTALDALLIAKGEKEVCLLPRMANRHGLVAGATGTGKTVTLRVLAERFSAIGVPVFMADVKGDLSGLALPGDENPKVAERVAKMGLEGFACSGFPVVFWDVFGEQGHPVRTTVSEMGPLLLSRLLNLNDVQSGVLNVIFKVADDNGLLLLDFKDLQAMVRYVGDNAAEFQTAYGNISAASIGAIQRNLLALGEQGAEQFFGEPALNLQDFMQTDSDGRGVINILAADKLMQSPKLYATFLLWMLSELFEQLPEAGDPEKPNLVFFFDEAHLLFDDAPKALVEKIEQVVRLIRSKGVGIYFVTQNPVDLPDTVLGQLGNRVQHALRAFTPKDQKGVRAAAETFRANPAFSVETVITQLEVGEALVSVLDGKGAPTVVERALVCPPQSRFAPLAGAERTAVIARSPLAGFYEKAVDRESAYETLKAKTEAAAPAPEEGKSEVASQVGTVLGAFAKSAAHAIGSQVGRQIIRGGLGSLFGGGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="57" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XP0</accession>
    <name>Q39XP0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Lipoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0742</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514459.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30984">
        <property type="protein sequence ID" value="ABB30984"/>
        <property type="gene ID" value="Gmet_0742"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0742"/>
    <dbReference type="eggNOG" id="ENOG503479N">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_149248_0_0_7"/>
    <dbReference type="OMA" id="PADYSWA"/>
    <dbReference type="OrthoDB" id="1977159at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004223498" evidence="1">
        <location>
            <begin position="34"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="132" mass="14054" checksum="66E64A4C6A408300" modified="2005-11-22" version="1">MTRPAPITGSASPRLGRLARLLAASALLTAACATLTPTTALDPNKLPPILAQDEIIRPYTKIGTVEVSRERLGHIDDLKNEADEWAYDALGAEAAKLGADAIILPEVQAKKGSYLFFPSTSIKAKGIAIRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="100" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XP1</accession>
    <name>Q39XP1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Helix-turn-helix transcriptional regulator, IclR family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514458.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0741"/>
    <dbReference type="DNASU" id="3740547"/>
    <dbReference type="EnsemblBacteria" id="ABB30983">
        <property type="protein sequence ID" value="ABB30983"/>
        <property type="gene ID" value="Gmet_0741"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0741"/>
    <dbReference type="eggNOG" id="COG1414">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_062618_6_0_7"/>
    <dbReference type="OMA" id="APIRGYG"/>
    <dbReference type="OrthoDB" id="370329at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014757">
        <property type="entry name" value="Tscrpt_reg_IclR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005471">
        <property type="entry name" value="Tscrpt_reg_IclR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09339">
        <property type="entry name" value="HTH_IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01614">
        <property type="entry name" value="IclR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00346">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="SSF46785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51077">
        <property type="entry name" value="HTH_ICLR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51078">
        <property type="entry name" value="ICLR_ED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH iclR-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="IclR-ED" evidence="4">
        <location>
            <begin position="73"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="255" mass="28216" checksum="A2965E312D77E43E" modified="2005-11-22" version="1">MTREKSSYAVQTVEKALDILETLTEESRHATLPYLAERLDLSRNKAFRLLATLESKGLVERDDASGIYRLGISSVELAQRLLNSTSLIRHSHPVMEKLARKHDEAVYIAVLKGEEVLFLDMVDCDQAIKTAPLVGKRFPFFTNAAGKAIKSLESADLLEKFFKKRRNGGTPDPALLQTELTAIRERGFAVDFDGLGEGIVTVAVAVRDYAGKVIGALTMLGPSFRLMASRLEEEIIPSLREGAEMLSLKFGYAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="110" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XU8</accession>
    <name>Q39XU8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Electron transfer flavoprotein, alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">etfA-1</name>
        <name evidence="10" type="ordered locus">Gmet_0684</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="10 11" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ETF alpha-subunit/FixB family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514075.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0684"/>
    <dbReference type="EnsemblBacteria" id="ABB30926">
        <property type="protein sequence ID" value="ABB30926"/>
        <property type="gene ID" value="Gmet_0684"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0684"/>
    <dbReference type="eggNOG" id="COG1145">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG2025">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_034178_1_1_7"/>
    <dbReference type="OMA" id="YKHVWVF"/>
    <dbReference type="OrthoDB" id="1400253at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01715">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014730">
        <property type="entry name" value="ETF_a/b_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001308">
        <property type="entry name" value="ETF_a/FixB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033947">
        <property type="entry name" value="ETF_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014731">
        <property type="entry name" value="ETF_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018206">
        <property type="entry name" value="ETF_asu_C_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43153">
        <property type="entry name" value="PTHR43153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01012">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00766">
        <property type="entry name" value="ETF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00893">
        <property type="entry name" value="ETF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="SSF52467"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00696">
        <property type="entry name" value="ETF_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="9">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="ABB30926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="443" mass="47845" checksum="8699B5F9056B9DA5" modified="2005-11-22" version="1">MTEPKKIKKPRGTARPIPGKCIACGARCQSACPVDAIEMSDAGEPIILSEKCIGCLKCVKVCPADALEMFFTPEELKILEELARQQAAGAAPAVEEEDAEEAALAQMLAAYRGVWVFVEQTEGEPAKVSWELMGVGAQLARDIGTELCAIVIGHGVEHLCREAFSYGATKAYLMDQDVFRFYRTEPYLDACCHLIDKYKPEIILMGATGMGRDLAGAVATRVKTGLTADCTGLDVDDKRNLRQTRPAFGGNIMATIMCDKFRPQMATVRPHVMPMPERMEGATGAIVREQITLNEADILTKVIEIIRDTKVGVDIAGAEFIVSGGRGLMGPENFAMLQELADELGGVVGASRSAVDAGWMPHDRQVGQTGKTVRPKIYIACGISGAIQHLVGMQDSDVVIAINRDKEAPIFQVATYGIVGDLFKIVPAITSQLRELKASKRKG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-12-12" modified="2022-08-03" version="106" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y09</accession>
    <name>EFG1_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Elongation factor G 1</fullName>
            <shortName evidence="1">EF-G 1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">fusA1</name>
        <name type="ordered locus">Gmet_0623</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365698.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y09"/>
    <dbReference type="SMR" id="Q39Y09"/>
    <dbReference type="STRING" id="269799.Gmet_0623"/>
    <dbReference type="PRIDE" id="Q39Y09"/>
    <dbReference type="EnsemblBacteria" id="ABB30865">
        <property type="protein sequence ID" value="ABB30865"/>
        <property type="gene ID" value="Gmet_0623"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0623"/>
    <dbReference type="eggNOG" id="COG0480">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002794_4_1_7"/>
    <dbReference type="OMA" id="AATTCHW"/>
    <dbReference type="OrthoDB" id="88967at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribosomal_S5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="SSF50447"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="SSF54211"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="SSF54980"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0251">Elongation factor</keyword>
    <keyword id="KW-0342">GTP-binding</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-0648">Protein biosynthesis</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000263454" description="Elongation factor G 1">
        <location>
            <begin position="1"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="tr-type G">
        <location>
            <begin position="8"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="17"/>
            <end position="24"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="81"/>
            <end position="85"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="135"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00054"/>
        </source>
    </evidence>
    <sequence length="692" mass="75920" checksum="03E78C020261179B" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-03-07" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y10</accession>
    <name>RS7_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">30S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpsG</name>
        <name type="ordered locus">Gmet_0622</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the 30S ribosomal subunit. Contacts proteins S9 and S11.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365697.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y10"/>
    <dbReference type="SMR" id="Q39Y10"/>
    <dbReference type="STRING" id="269799.Gmet_0622"/>
    <dbReference type="EnsemblBacteria" id="ABB30864">
        <property type="protein sequence ID" value="ABB30864"/>
        <property type="gene ID" value="Gmet_0622"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0622"/>
    <dbReference type="eggNOG" id="COG0049">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_072226_1_1_7"/>
    <dbReference type="OMA" id="NVMPHVE"/>
    <dbReference type="OrthoDB" id="1540940at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00480_B">
        <property type="entry name" value="Ribosomal_S7_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_S5/S7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005717">
        <property type="entry name" value="Ribosomal_S7_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_S7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_S7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="PTHR11205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="SSF47973"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01029">
        <property type="entry name" value="rpsG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <keyword id="KW-0820">tRNA-binding</keyword>
    <feature type="chain" id="PRO_0000226502" description="30S ribosomal protein S7">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00480"/>
        </source>
    </evidence>
    <sequence length="156" mass="17750" checksum="E16FB9D41923950C" modified="2005-11-22" version="1">MPRRREVAKRVILPDPKFNDRVVAKLVNVIMVGGKKSTAERALYGALEVVSQKTGEEAVKVLKKCLDNIKPTLEVKSRRVGGSTYQVPVEVRADRRVSLAMRWLVKYANDRSEKTVTDKLAGEILDVYNNRGAAVKKREDTHRMAEANRAFAHYRW</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-06-27" modified="2022-08-03" version="94" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y12</accession>
    <name>RPOC_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase subunit beta'</fullName>
            <shortName evidence="1">RNAP subunit beta'</shortName>
            <ecNumber evidence="1">2.7.7.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">RNA polymerase subunit beta'</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Transcriptase subunit beta'</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rpoC</name>
        <name type="ordered locus">Gmet_0620</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1)</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514636.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y12"/>
    <dbReference type="SMR" id="Q39Y12"/>
    <dbReference type="STRING" id="269799.Gmet_0620"/>
    <dbReference type="PRIDE" id="Q39Y12"/>
    <dbReference type="EnsemblBacteria" id="ABB30862">
        <property type="protein sequence ID" value="ABB30862"/>
        <property type="gene ID" value="Gmet_0620"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0620"/>
    <dbReference type="eggNOG" id="COG0086">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000524_3_1_7"/>
    <dbReference type="OMA" id="YRNIRVE"/>
    <dbReference type="OrthoDB" id="4421at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed 5'-3' RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01322">
        <property type="entry name" value="RNApol_bact_RpoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012754">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="PTHR19376"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02386">
        <property type="entry name" value="rpoC_TIGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0804">Transcription</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000240804" description="DNA-directed RNA polymerase subunit beta'">
        <location>
            <begin position="1"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="810"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="884"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="891"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="894"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01322"/>
        </source>
    </evidence>
    <sequence length="1392" mass="155029" checksum="47CC262891FD20BF" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="91" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y17</accession>
    <name>RL11_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">50S ribosomal protein L11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">rplK</name>
        <name type="ordered locus">Gmet_0615</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">One or more lysine residues are methylated.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514631.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39Y17"/>
    <dbReference type="SMR" id="Q39Y17"/>
    <dbReference type="STRING" id="269799.Gmet_0615"/>
    <dbReference type="EnsemblBacteria" id="ABB30857">
        <property type="protein sequence ID" value="ABB30857"/>
        <property type="gene ID" value="Gmet_0615"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0615"/>
    <dbReference type="eggNOG" id="COG0080">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_074237_2_1_7"/>
    <dbReference type="OMA" id="CKQFNAK"/>
    <dbReference type="OrthoDB" id="1702697at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_L11/L12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_L11/L12_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006519">
        <property type="entry name" value="Ribosomal_L11_bac-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_L11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_L11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_L11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="PTHR11661"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="SSF46906"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="SSF54747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01632">
        <property type="entry name" value="L11_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0488">Methylation</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0687">Ribonucleoprotein</keyword>
    <keyword id="KW-0689">Ribosomal protein</keyword>
    <keyword id="KW-0694">RNA-binding</keyword>
    <keyword id="KW-0699">rRNA-binding</keyword>
    <feature type="chain" id="PRO_0000258157" description="50S ribosomal protein L11">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00736"/>
        </source>
    </evidence>
    <sequence length="140" mass="14758" checksum="1E35D0337CA25476" modified="2005-11-22" version="1">MAKKITGYIKLQIPAGKANPSPPIGPALGQHGVNIMEFCKAFNAKTQGDEGTITPVVITVYADRSFSFITKVPPMSVLIKKAVGIESGSSVPNKNKVGTLTAEQVKEIAVKKMPDMNAASLEAAMRTVEGTARSMGVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="76" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y31</accession>
    <name>Q39Y31_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0600"/>
    <dbReference type="EnsemblBacteria" id="ABB30843">
        <property type="protein sequence ID" value="ABB30843"/>
        <property type="gene ID" value="Gmet_0600"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0600"/>
    <dbReference type="eggNOG" id="COG0484">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG3291">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_349435_0_0_7"/>
    <dbReference type="OMA" id="MPANHIP"/>
    <dbReference type="OrthoDB" id="738283at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036280">
        <property type="entry name" value="Multihaem_cyt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022409">
        <property type="entry name" value="PKD/Chitinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000601">
        <property type="entry name" value="PKD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035986">
        <property type="entry name" value="PKD_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00089">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48695">
        <property type="entry name" value="SSF48695"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49299">
        <property type="entry name" value="SSF49299"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50093">
        <property type="entry name" value="PKD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PKD" evidence="1">
        <location>
            <begin position="477"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="712" mass="75578" checksum="ED222BBB94D68634" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-01-19" version="63" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y58</accession>
    <name>Q39Y58_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ResC/HemX-like cytochrome c</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512270.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0573"/>
    <dbReference type="EnsemblBacteria" id="ABB30816">
        <property type="protein sequence ID" value="ABB30816"/>
        <property type="gene ID" value="Gmet_0573"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0573"/>
    <dbReference type="eggNOG" id="COG0755">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_049710_2_2_7"/>
    <dbReference type="OMA" id="DVYAYRF"/>
    <dbReference type="OrthoDB" id="213184at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017004">
        <property type="term" value="P:cytochrome complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002541">
        <property type="entry name" value="Cyt_c_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045062">
        <property type="entry name" value="Cyt_c_biogenesis_CcsA/CcmC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30071">
        <property type="entry name" value="PTHR30071"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01578">
        <property type="entry name" value="Cytochrom_C_asm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrom_C_asm" evidence="6">
        <location>
            <begin position="75"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="278" mass="32185" checksum="FE74C57D38E099C0" modified="2005-11-22" version="1">MFNGNDPVIIDVSVHWIAVIVYVLATISNVWGVVFTKKKAVQWSYFLAYLGLAIHGLVLLYRWVITGHGPYMARYEILSSNAWVLLVLFLVFGKVYPKIKPASIVVFPATFLLIALGLFFNPEMTRMPPSMRSIWLVLHVLFYKISVATILVALAFSLVLILKTRTSYTWLERLPSIEVVDVYAYRFAGFSFVFWAIAMLAGSIWAYQLWGRFWGWDPVETWSLITWGAFGMYLHLRRFFGWKGERAAYFYLLCTFVSIVALYFTPLLETSIHSEYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="58" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Y66</accession>
    <name>Q39Y66_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365686.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0565"/>
    <dbReference type="EnsemblBacteria" id="ABB30808">
        <property type="protein sequence ID" value="ABB30808"/>
        <property type="gene ID" value="Gmet_0565"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0565"/>
    <dbReference type="HOGENOM" id="CLU_2246115_0_0_7"/>
    <dbReference type="OMA" id="DVMWREE"/>
    <dbReference type="OrthoDB" id="2098474at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027569">
        <property type="entry name" value="Geo_PqqD_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008792">
        <property type="entry name" value="PQQD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041881">
        <property type="entry name" value="PqqD_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05402">
        <property type="entry name" value="PqqD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR04302">
        <property type="entry name" value="geo_PqqD_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="104" mass="11594" checksum="0ABF1F2E85ECEFEC" modified="2005-11-22" version="1">MKTIHRNPNVMWREEADALARVQEAMDRGEEVEETGTSVLFSGGTMLSLNFLGTEIWKLCDGRALDGIVAELLPQFEVDEAVLREDVRAFLDELAAKGFVSHAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="122" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YA4</accession>
    <name>Q39YA4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sensor protein</fullName>
            <ecNumber evidence="5">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ordered locus">Gmet_0527</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="9 10" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Member of a two-component regulatory system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cell inner membrane</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="5"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365675.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0527"/>
    <dbReference type="EnsemblBacteria" id="ABB30770">
        <property type="protein sequence ID" value="ABB30770"/>
        <property type="gene ID" value="Gmet_0527"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0527"/>
    <dbReference type="eggNOG" id="COG2205">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_89_6_7"/>
    <dbReference type="OMA" id="EFLGWMI"/>
    <dbReference type="OrthoDB" id="692375at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006290">
        <property type="entry name" value="CztS_silS_copS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01386">
        <property type="entry name" value="cztS_silS_copS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="8">
        <location>
            <begin position="201"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="7">
        <location>
            <begin position="262"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="246"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="ABB30770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="477" mass="52548" checksum="0B338FE699406234" modified="2005-11-22" version="1">MSSTEREVTHPGALSLTARLTILSTLATTCVLLFVIVFQFLALASDLEFEDNNFIIEKIRVIEAIIARYPDDSAHLDQEVNWEGALRQDTRYLVRIMGRQGNVVMETRGMDRIVPARQFPPPARDSRAIGQGKKLHVQDGRIYLLNSAWGMSEKGLSSRFIQVALDVTDDEDILQGYKQKMAFVFLAGICLSAALSAVVVRRGLRPLAEITGAAGRIDVTTLDERLGARVWPRELARFAAAFDGMLDRLETSFDRLEASSANLAHEIRTPINILRGEAEVAISRARSAEEYRRVIESSLEEYERLSRLIDNILFLARAEQRIEPIPLDMRGELELLLDFYGTLAEEKEITISCSGRGEIHADPLLFQRAVGNLLSNAIRYTPTGGAITVSFTRDNDGAAHLTVTDTGIGIAPDDLLRVFDRFYRSSEARALNAQGTGLGLAIVRSIMDLHGGSVSVSSEPGRGTAVTLHFPAAPSPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="104" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YA8</accession>
    <name>Q39YA8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter, ATP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ordered locus">Gmet_0523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="5 6" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512219.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0523"/>
    <dbReference type="EnsemblBacteria" id="ABB30766">
        <property type="protein sequence ID" value="ABB30766"/>
        <property type="gene ID" value="Gmet_0523"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0523"/>
    <dbReference type="eggNOG" id="COG1116">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="eggNOG" id="COG4754">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_027829_2_3_7"/>
    <dbReference type="OMA" id="INWGRYG"/>
    <dbReference type="OrthoDB" id="1713578at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018632">
        <property type="entry name" value="AAA-associated_dom_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09821">
        <property type="entry name" value="AAA_assoc_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="10"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="ABB30766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="435" mass="47698" checksum="36DCC1580ACE66D1" modified="2005-11-22" version="1">MTTSASAELLRLDNIRKSYRKTEGDEHLVLDGVALTVGEGEIVALLGRSGSGKSTLLRIISGLVPPGGGTVSYGGNPVTGPVEGVAMVFQTFALMPWLTVLENVELGLLARRVPAAERRRRALEAIDLIGLDGFESAFPKELSGGMRQRVGFARALVVEPDLLLMDEPFSALDVLTAETLRTDLIELWIERRIPTRGIILVSHNIEESVLLADRIVILGSSPGRIVAEVPVPLPHPRDREAPAFRKLVDDVYALMTEKPRGAARPEGVPIGHRLPDASVSRLTGLIDALAREPYRGRADLPEIADDQGLSVDHLFPLLEALEILGFARVEAGDVELTPSGRSFAEADILRQKEIFAEHLVRRVSLAAHIRRVLDERPGNRAPEERFLRELEDYLSEDEAQRVLRVVIEWGRNAEIFAYDESAGVLSLENPVEAEG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-10-31" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YF3</accession>
    <name>CBID_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalt-precorrin-5B C(1)-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.195</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cobalt-precorrin-6A synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cbiD</name>
        <name type="ordered locus">Gmet_0478</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Co-precorrin-5B + S-adenosyl-L-methionine = Co-precorrin-6A + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:26285"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:60063"/>
            <dbReference type="ChEBI" id="CHEBI:60064"/>
            <dbReference type="EC" id="2.1.1.195"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; adenosylcobalamin biosynthesis; cob(II)yrinate a,c-diamide from sirohydrochlorin (anaerobic route): step 6/10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CbiD family.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.195" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513847.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YF3"/>
    <dbReference type="SMR" id="Q39YF3"/>
    <dbReference type="STRING" id="269799.Gmet_0478"/>
    <dbReference type="PRIDE" id="Q39YF3"/>
    <dbReference type="EnsemblBacteria" id="ABB30721">
        <property type="protein sequence ID" value="ABB30721"/>
        <property type="gene ID" value="Gmet_0478"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0478"/>
    <dbReference type="eggNOG" id="COG1903">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_041273_0_0_7"/>
    <dbReference type="OMA" id="YHGKLIK"/>
    <dbReference type="OrthoDB" id="1282567at2"/>
    <dbReference type="UniPathway" id="UPA00148">
        <property type="reaction ID" value="UER00227"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043780">
        <property type="term" value="F:cobalt-precorrin-5B C1-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046140">
        <property type="term" value="P:corrin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00787">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002748">
        <property type="entry name" value="CbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036074">
        <property type="entry name" value="CbiD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35863">
        <property type="entry name" value="PTHR35863"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01888">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026782">
        <property type="entry name" value="CbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111342">
        <property type="entry name" value="SSF111342"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00312">
        <property type="entry name" value="cbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0489">Methyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000257763" description="Cobalt-precorrin-5B C(1)-methyltransferase">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00787"/>
        </source>
    </evidence>
    <sequence length="369" mass="39351" checksum="02AC6B693C6E1397" modified="2005-11-22" version="1">MNTKPLRHGYTTGACAAAAAKGAARMLREQRPVEEVELVLPKGERVAFRLHGQEFDDSAASCFVVKDAGDDPDVTNGAEIHARVRREPLNRSGARTMVFVDGGKGVGTVTKPGLGVGVGNPAINPVPMRMITEGVKEEFSVVCLPQVLHVTISIPNGEELAKKTLNARLGIVGGLSILGTTGIVRPISAKAWTDTLDAALDVARACGCETIVLSTGRTSELVAIHAGIGDRGPGTGKTLPEEAYVMMGDHVGYALRACARKGVRHVILVGQFAKLLKIACGHEQTHVSSSELDLQMLAEWLHELGSRSPVPGPWSRYNTARQVLEESGNDSLFMELVCTRARDAARRLAPSLDIKVLLAGYDSTVLYFG</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2008-01-15" modified="2022-05-25" version="92" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YG4</accession>
    <name>COBT_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase</fullName>
            <shortName evidence="1">NN:DBI PRT</shortName>
            <ecNumber evidence="1">2.4.2.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">N(1)-alpha-phosphoribosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">cobT</name>
        <name type="ordered locus">Gmet_0467</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate</text>
            <dbReference type="Rhea" id="RHEA:11196"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15890"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:57918"/>
            <dbReference type="EC" id="2.4.2.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleoside biosynthesis; alpha-ribazole biosynthesis; alpha-ribazole from 5,6-dimethylbenzimidazole: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CobT family.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.21" evidence="1"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513836.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39YG4"/>
    <dbReference type="SMR" id="Q39YG4"/>
    <dbReference type="STRING" id="269799.Gmet_0467"/>
    <dbReference type="EnsemblBacteria" id="ABB30710">
        <property type="protein sequence ID" value="ABB30710"/>
        <property type="gene ID" value="Gmet_0467"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0467"/>
    <dbReference type="eggNOG" id="COG2038">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_002982_0_0_7"/>
    <dbReference type="OMA" id="AWMRKCA"/>
    <dbReference type="OrthoDB" id="1765140at2"/>
    <dbReference type="UniPathway" id="UPA00061">
        <property type="reaction ID" value="UER00516"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008939">
        <property type="term" value="F:nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009236">
        <property type="term" value="P:cobalamin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02439">
        <property type="entry name" value="DMB-PRT_CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1610.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00230">
        <property type="entry name" value="CobT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003200">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017846">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_bact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023195">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036087">
        <property type="entry name" value="Nict_dMeBzImd_PRibTrfase_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02277">
        <property type="entry name" value="DBI_PRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52733">
        <property type="entry name" value="SSF52733"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03160">
        <property type="entry name" value="cobT_DBIPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0169">Cobalamin biosynthesis</keyword>
    <keyword id="KW-0328">Glycosyltransferase</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_1000021597" description="Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00230"/>
        </source>
    </evidence>
    <sequence length="353" mass="36518" checksum="CCB55A3C201A5CFB" modified="2005-11-22" version="1">MTLLTETLSNIRPVDAGLMAQAQARLDNKTKPIGSLGRLEEFARRTVAISGSLDPSTAKKAIFTFAADHGVVEEGVSAFPKEVTVQMVFNFLKGGAGINVLANHVGADVLVVDMGIDHDFGDTPGLIDRKVARGTRNMAKGPAMTREEAVTALEAGIELACGCKADGVAMAGTGEMGIGNTTAASAIIAAFSGKTVADVTHRGTGINDAALAKKVTIIEQALAVNRPDPKDPIDVLAKVGGLEIAGIAGLVLGCAANRIPVVVDGFISTAGALIACELCPTVKEYIFAAHESVEIGHRFMLERIGAEPILDLHLRLGEGTGAALAMGLIEAGVKILKEMATFAEAGVEKGRDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="75" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YG7</accession>
    <name>Q39YG7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Metal-dependent phosphohydrolase, HDOD domain-containing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513833.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0464"/>
    <dbReference type="DNASU" id="3739831"/>
    <dbReference type="EnsemblBacteria" id="ABB30707">
        <property type="protein sequence ID" value="ABB30707"/>
        <property type="gene ID" value="Gmet_0464"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0464"/>
    <dbReference type="eggNOG" id="COG1639">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_048246_4_2_7"/>
    <dbReference type="OMA" id="LTEKMLW"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006675">
        <property type="entry name" value="HDIG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013976">
        <property type="entry name" value="HDOD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08668">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00277">
        <property type="entry name" value="HDIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51833">
        <property type="entry name" value="HDOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HDOD" evidence="1">
        <location>
            <begin position="15"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="284" mass="31376" checksum="9036E6E51E2B1E22" modified="2005-11-22" version="1">MNKELETLIMSAVDLPTIPVVATKVIELIEQEDVTIEKLATAVSSDPAVAARILKLSNSAYYGCQRQINTLSAAIMLLGFKTLKSLVIAASLKQLNRRFGLTEKMLWEHSVGAALAGRVIATQGRFINEETGFLVGLFHDLGKTIMSNRDPQKFQGVMMRCYNEGIPFAEAERSVYPYSHAEVGALVIRKWNFPESLSTAIMHHHQFGSAPITDQYDLFLTATASLANKFCKKLGIGDRDADDDLNLTNAPEAMLLGFTSDTAEKALATFQETFEENKSFFLND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YN0</accession>
    <name>Q39YN0_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30644.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512373.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0401"/>
    <dbReference type="EnsemblBacteria" id="ABB30644">
        <property type="protein sequence ID" value="ABB30644"/>
        <property type="gene ID" value="Gmet_0401"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0401"/>
    <dbReference type="eggNOG" id="ENOG5034AST">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_1592210_0_0_7"/>
    <dbReference type="OMA" id="CITFNCE"/>
    <dbReference type="OrthoDB" id="1945629at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30644.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="170" mass="19014" checksum="35C9297D22F2D597" modified="2012-10-31" version="2">MNDRERWDCAIAAVSADYAALPSALQGEVKTLATAIRGARRELHSLAQEMGSGTICASCGGQCCLRGKYHVTVADILVFLAEGEPLFTPRFNRDVCPYLDDYGCMMAPSLRPFPCITFNCERIEELWEPERIAAFYRGERQLRALYGKLEQLFAHRAGAARRMAILGYNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YN8</accession>
    <name>Q39YN8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Membrane protein implicated in colicin V production</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0393</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512365.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0393"/>
    <dbReference type="EnsemblBacteria" id="ABB30636">
        <property type="protein sequence ID" value="ABB30636"/>
        <property type="gene ID" value="Gmet_0393"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0393"/>
    <dbReference type="eggNOG" id="COG1286">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_092720_4_3_7"/>
    <dbReference type="OMA" id="SPEWANI"/>
    <dbReference type="OrthoDB" id="1840581at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003825">
        <property type="entry name" value="Colicin-V_CvpA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02674">
        <property type="entry name" value="Colicin_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB30636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="178" mass="18786" checksum="0CF18AE9AF40144E" modified="2005-11-22" version="1">MSLLDILLWAVLLGFAAKGFMKGFVREVCSLLGLVTGGWAAFTYYQAAGAFLGNLIHLPPRVASAVAFLCILLAIGLLFFLVGHLLTVILKIVLLGGVNRVGGIVFGLLQGGLLLSIVLYLASSPSVPQGVRGRIAASGSARALADCGKDIVTGWRKNAVEKRPAGENRTKDVTDPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="105" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YU1</accession>
    <name>Q39YU1_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cold shock DNA/RNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ordered locus">Gmet_0340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512312.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0340"/>
    <dbReference type="EnsemblBacteria" id="ABB30583">
        <property type="protein sequence ID" value="ABB30583"/>
        <property type="gene ID" value="Gmet_0340"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0340"/>
    <dbReference type="eggNOG" id="COG1278">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_117621_6_1_7"/>
    <dbReference type="OMA" id="FICKDQG"/>
    <dbReference type="OrthoDB" id="2034748at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProt"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019844">
        <property type="entry name" value="CSD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="SSF50249"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00352">
        <property type="entry name" value="CSD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="66" mass="7181" checksum="E31F13A9E779B80D" modified="2005-11-22" version="1">MANGTVKWFNDSKGFGFLEQENGEDVFVHFSAINGDGFKSLTEGDRVTFDVVKGPKGLQAANVTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="116" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YU4</accession>
    <name>Q39YU4_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">GTP 3',8-cyclase</fullName>
            <ecNumber evidence="3 12">4.1.99.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Molybdenum cofactor biosynthesis protein A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="primary">moaA-2</name>
        <name evidence="12" type="synonym">moaA</name>
        <name evidence="14" type="ordered locus">Gmet_0337</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="14 15" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>AH2 + GTP + S-adenosyl-L-methionine = (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate + 5'-deoxyadenosine + A + H(+) + L-methionine</text>
            <dbReference type="Rhea" id="RHEA:49576"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:131766"/>
            <dbReference type="EC" id="4.1.99.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="12">Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer and homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the radical SAM superfamily. MoaA family.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.22" evidence="3 12"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512309.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0337"/>
    <dbReference type="EnsemblBacteria" id="ABB30580">
        <property type="protein sequence ID" value="ABB30580"/>
        <property type="gene ID" value="Gmet_0337"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0337"/>
    <dbReference type="eggNOG" id="COG2896">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_009273_0_1_7"/>
    <dbReference type="OMA" id="IEFMPIG"/>
    <dbReference type="OrthoDB" id="1199289at2"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019008">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061798">
        <property type="term" value="F:GTP 3',8'-cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01225_B">
        <property type="entry name" value="MoaA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaB/NifB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013483">
        <property type="entry name" value="MoaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000385">
        <property type="entry name" value="MoaA_NifB_PqqE_Fe-S-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010505">
        <property type="entry name" value="Mob_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06463">
        <property type="entry name" value="Mob_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR02666">
        <property type="entry name" value="moaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01305">
        <property type="entry name" value="MOAA_NIFB_PQQE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="9 12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 12" id="KW-0408">Iron</keyword>
    <keyword evidence="8 12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="13">
        <location>
            <begin position="6"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-substrate</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="ABB30580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="326" mass="35401" checksum="AD2C294FD9F522AB" modified="2005-11-22" version="1">MELIDTYGRRITYLRLSVTDRCNLRCRYCMPAAGVEKLGHGDILSYEDLFRIARAAVAVGIEKIRVTGGEPLVRKGIVPFLARLAKLPGLRELVLTTNGFLLPEMAGELRRAGVQRLNVSLDSFRPGTFRAITRGGDVWQVLAGIAAAEAAGFPPPKINMVVMRGVNDDEVLDFARLTIEHPYAVRFIESMPATREKNWQNLTIAGEEILERIGTQFSLEPVGKGSLAGPSRDFRLRGAAGTIGIITALSGHFCADCNRIRVTSTGMAKSCLFSDGGIDLKPFLRCEGSKPLAEALRNLACAKPACHGMSMERAEHRAFAMAAVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="46" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YW2</accession>
    <name>Q39YW2_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_0318</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514029.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="EnsemblBacteria" id="ABB30562">
        <property type="protein sequence ID" value="ABB30562"/>
        <property type="gene ID" value="Gmet_0318"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0318"/>
    <dbReference type="HOGENOM" id="CLU_1110170_0_0_7"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB30562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="250" mass="28949" checksum="FE14BF72C176F143" modified="2005-11-22" version="1">MSNSLNDQIDFHIPERHEFCSGYEIYNQRERRGPIWFDALEVINKNWGNASEMERGVSRIIRGWNRFYARYDKNAVIASIDRNIDSLSNLRDRGIETLTTLDSELLTTLFNDFLSSLKRLNDNRKSPVSVAKTLSLFAPAFLPIWDSNIAWKYNCFYIDGDSHIKYLKFCEKIKYSRKEFENLFRTATIVHFSRESTNTTIQSTQSTGFKGATGKKKRDRLLFEERIAEGMKACGKTSPSPIFFVDSGCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="78" xmlns="http://uniprot.org/uniprot">
    <accession>Q39YZ3</accession>
    <name>Q39YZ3_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Type VI secretion system needle syringe protein TssI</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">tssI</name>
        <name evidence="3" type="ordered locus">Gmet_0286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="3 4" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VgrG protein family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513997.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0286"/>
    <dbReference type="EnsemblBacteria" id="ABB30531">
        <property type="protein sequence ID" value="ABB30531"/>
        <property type="gene ID" value="Gmet_0286"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0286"/>
    <dbReference type="eggNOG" id="COG3501">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_004121_3_0_7"/>
    <dbReference type="OMA" id="NTHTIES"/>
    <dbReference type="OrthoDB" id="1880900at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006531">
        <property type="entry name" value="Gp5/Vgr_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010609">
        <property type="entry name" value="Gp5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017847">
        <property type="entry name" value="T6SS_RhsGE_Vgr_subset"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006533">
        <property type="entry name" value="T6SS_Vgr_RhsGE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037026">
        <property type="entry name" value="Vgr_OB-fold_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06715">
        <property type="entry name" value="Gp5_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04717">
        <property type="entry name" value="Phage_base_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR01646">
        <property type="entry name" value="vgr_GE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR03361">
        <property type="entry name" value="VI_Rhs_Vgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phage_base_V" evidence="2">
        <location>
            <begin position="395"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="ABB30531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="709" mass="78013" checksum="8BD5CF1B10E1E2BA" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="113" xmlns="http://uniprot.org/uniprot">
    <accession>Q39Z74</accession>
    <name>Q39Z74_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acetylornithine aminotransferase</fullName>
            <shortName evidence="2">ACOAT</shortName>
            <ecNumber evidence="2">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2 4" type="primary">argD</name>
        <name evidence="4" type="ordered locus">Gmet_0204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="4 5" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>2-oxoglutarate + N(2)-acetyl-L-ornithine = L-glutamate + N-acetyl-L-glutamate 5-semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:18049"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29123"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.6.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
        <text evidence="2">Binds 1 pyridoxal phosphate per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="2">May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512793.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0204"/>
    <dbReference type="EnsemblBacteria" id="ABB30450">
        <property type="protein sequence ID" value="ABB30450"/>
        <property type="gene ID" value="Gmet_0204"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0204"/>
    <dbReference type="eggNOG" id="COG4992">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_016922_10_1_7"/>
    <dbReference type="OMA" id="PFMVPTY"/>
    <dbReference type="OrthoDB" id="572533at2"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="SSF53383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 4" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="2" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="105"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Pyridoxal phosphate binding" evidence="2">
        <location>
            <begin position="224"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>N(2)-acetyl-L-ornithine</name>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="ABB30450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="399" mass="43325" checksum="BA0E2C157EE97826" modified="2005-11-22" version="1">MKSADWIAKGDKYIMKTYGRYPLVPVRGEGCRVWDADGKEYLDFLAGVAVNNLGHCHPKVVAALQKQAAEMIHCSNYYNIPTQIELAELLCSNSFADKAFFCNSGAEANEAAIKLARKYAREKTGDVERYEIITAIASFHGRTMATISATGQEKVQKFFDPLLHGFTYVPFDDADALEAAVTPKTCAVMLEPIQGEGGVVIPSADYFRKVREICDRHGLLLIFDEVQVGIGRTGKLFAHEHFDVTPDIMTLAKALAGGAPIGSMLAKDEVAASFSPGTHGSTFGGNPLVTAAGVAAVRAVLEEGLLNRAEEMGEYLVGELERLKEKYAFITDVRGIGLMIGMELSAPAGEIVLKGLERGVLLNVAQDKVLRFVPPLIVTKQEVNEMIAVLDGILEEIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2020-12-02" version="64" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZA8</accession>
    <name>Q39ZA8_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nodulin 21-like membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ordered locus">Gmet_0169</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="7 8" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004512756.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0169"/>
    <dbReference type="EnsemblBacteria" id="ABB30416">
        <property type="protein sequence ID" value="ABB30416"/>
        <property type="gene ID" value="Gmet_0169"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0169"/>
    <dbReference type="eggNOG" id="COG1814">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_038957_3_0_7"/>
    <dbReference type="OMA" id="SRIGWLR"/>
    <dbReference type="OrthoDB" id="1717935at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:cellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="PTHR31851"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="ABB30416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="230" mass="23383" checksum="F528B4B47E77588E" modified="2005-11-22" version="1">MSTKSETHYAERIGWLRAAVLGANDGIISTASLVVGVAAAHAARGNVLIAGVAGLVAGTMSMAAGEYVSVSSQADTEKADLARERRELEEDHEFELKELASIYVDRGLEPQLAKQVATQLMAHDALAAHARDELGLNEIHTARPIQAALASAVTFAVGATLPLIITLLSPEQLIVPGVAGGSLVCLALLGTLAARAGGADIAVGATRVTLWGALAMAATAGVGALFGTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-05-25" version="79" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZF7</accession>
    <name>Q39ZF7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hydrogenase assembly chaperone HypC/HupF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="primary">hypC</name>
        <name evidence="2" type="ordered locus">Gmet_0118</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HupF/HypC family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004514123.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0118"/>
    <dbReference type="EnsemblBacteria" id="ABB30367">
        <property type="protein sequence ID" value="ABB30367"/>
        <property type="gene ID" value="Gmet_0118"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0118"/>
    <dbReference type="eggNOG" id="COG0298">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_159381_2_2_7"/>
    <dbReference type="OMA" id="HYPARVD"/>
    <dbReference type="OrthoDB" id="2031925at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019812">
        <property type="entry name" value="Hydgase_assmbl_chp_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001109">
        <property type="entry name" value="Hydrogenase_HupF/HypC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35177">
        <property type="entry name" value="PTHR35177"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01455">
        <property type="entry name" value="HupF_HypC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00445">
        <property type="entry name" value="HUPFHYPC"/>
    </dbReference>
    <dbReference type="TIGRFAMs" id="TIGR00074">
        <property type="entry name" value="hypC_hupF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01097">
        <property type="entry name" value="HUPF_HYPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="76" mass="8409" checksum="1AECE6BF8E063E0D" modified="2005-11-22" version="1">MCLGVPMQVVSVGDGDIVAEIDGVRKEASLMLLDEEVKEGDFVIVHAGFAISRLDEEEAQETLRLMREVFKPEDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="90" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZI7</accession>
    <name>Q39ZI7_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sigma-54-dependent transcriptional regulator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ordered locus">Gmet_0088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="2 3" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30337.2"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_011365622.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0088"/>
    <dbReference type="EnsemblBacteria" id="ABB30337">
        <property type="protein sequence ID" value="ABB30337"/>
        <property type="gene ID" value="Gmet_0088"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0088"/>
    <dbReference type="eggNOG" id="COG3829">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_555320_0_0_7"/>
    <dbReference type="OMA" id="DFYYRLC"/>
    <dbReference type="OrthoDB" id="123059at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of transcription, DNA-templated"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002078">
        <property type="entry name" value="Sigma_54_int"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00158">
        <property type="entry name" value="Sigma54_activat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="SSF52540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50045">
        <property type="entry name" value="SIGMA54_INTERACT_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sigma-54 factor interaction" evidence="1">
        <location>
            <begin position="169"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="ABB30337.2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="503" mass="56809" checksum="82AD1E6E89E4BDB6" modified="2012-10-31" version="2">MTFYEWQLYIECMKAIETILATERDFFAKVARAAFLNPFGESRDELDLLLAGTGAGDRGGVLAAIIARVAERTAVLQRELRGNHHRLPAADRETVRTVLLFDLFHRFLDSFDRLIREQAVGGDSPCPVPFAGGFQAAFAEAGFSETESRRYLGLFYQLRRAFYFIREGLAGSSPSLRRVREHLWQTLFTHNIRWFDQYLWDRMEDFSVLILGETGTGKGAAAAAIGRSGFIPFDPKTGRFSESFTRNFLAVNLSQYPEGVLESELFGHRKGAFTGAIDHHEGVFSRCTPHGAIFLDEIGEVPLPVQVKLLQVLQERSFSPVGSHQRLRFSGRVIAATNRDLTRLREQGEFRDDFYYRLCSDVITIPPLRQRLQECPDELGELVAGILTRLTGTAPKREVQLLRKAIERETGKGYHWPGNVRELEQAVRRVLVTGHYRGEEKGAPSGVTEQFLADVAAGGLDAQGLLAGYCRILYERHDTYEEVARRANLDRRTVKKYLQQAGE</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2006-05-30" modified="2022-05-25" version="84" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZN3</accession>
    <name>HSLO_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">33 kDa chaperonin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Heat shock protein 33 homolog</fullName>
            <shortName evidence="1">HSP33</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">hslO</name>
        <name type="ordered locus">Gmet_0041</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="1">Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSP33 family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513808.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZN3"/>
    <dbReference type="SMR" id="Q39ZN3"/>
    <dbReference type="STRING" id="269799.Gmet_0041"/>
    <dbReference type="EnsemblBacteria" id="ABB30291">
        <property type="protein sequence ID" value="ABB30291"/>
        <property type="gene ID" value="Gmet_0041"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0041"/>
    <dbReference type="eggNOG" id="COG1281">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_054493_1_0_7"/>
    <dbReference type="OMA" id="DMQCECC"/>
    <dbReference type="OrthoDB" id="1406579at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00498">
        <property type="entry name" value="Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.30.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00117">
        <property type="entry name" value="HslO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000397">
        <property type="entry name" value="Heat_shock_Hsp33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016154">
        <property type="entry name" value="Heat_shock_Hsp33_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016153">
        <property type="entry name" value="Heat_shock_Hsp33_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30111">
        <property type="entry name" value="PTHR30111"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01430">
        <property type="entry name" value="HSP33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005261">
        <property type="entry name" value="Heat_shock_Hsp33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118352">
        <property type="entry name" value="SSF118352"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64397">
        <property type="entry name" value="SSF64397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0143">Chaperone</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1015">Disulfide bond</keyword>
    <keyword id="KW-0676">Redox-active center</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000238068" description="33 kDa chaperonin">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="244"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="1">
        <location>
            <begin position="277"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_00117"/>
        </source>
    </evidence>
    <sequence length="301" mass="32104" checksum="FF47E1441EB01F8E" modified="2005-11-22" version="1">MGNSTDSIITDYLVRVIARDGSIRALACVTTGLVGELCRRHGTWPTASAALGRAVTGGALMGALLKTGQRVALRFEGNGPLKNILVEADANGAVRGCVGNPEANPLREDGKLDVAAAIGQAGLLTVTKDLGLKEPYTGTVLLYTSEIAEDLAYYLTDSEQVPSAVGLGVFVEPDGAVAAAGGFLIQSLPPHNDEAVDRLMERIGAMPPVTELLRQGKSPEGLLEYLFEGIPYDTLEKRALAFVCSCSRERIERVLISLGRDDLASLLAEQGETEVTCEFCREHYHFGRDDLERLLAGISAM</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2007-03-06" modified="2022-05-25" version="85" xmlns="http://uniprot.org/uniprot">
    <accession>Q39ZN5</accession>
    <name>KUP2_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Probable potassium transport system protein kup 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">kup2</name>
        <name type="ordered locus">Gmet_0039</name>
    </gene>
    <organism>
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transport of potassium into the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAK/KUP transporter (TC 2.A.72) family.</text>
    </comment>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB30289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513806.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q39ZN5"/>
    <dbReference type="STRING" id="269799.Gmet_0039"/>
    <dbReference type="PRIDE" id="Q39ZN5"/>
    <dbReference type="EnsemblBacteria" id="ABB30289">
        <property type="protein sequence ID" value="ABB30289"/>
        <property type="gene ID" value="Gmet_0039"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0039"/>
    <dbReference type="eggNOG" id="COG3158">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_008142_4_2_7"/>
    <dbReference type="OMA" id="LMIMCIV"/>
    <dbReference type="OrthoDB" id="589903at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016021">
        <property type="term" value="C:integral component of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01522">
        <property type="entry name" value="Kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023051">
        <property type="entry name" value="K+_uptake_low_affin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="PTHR30540"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0997">Cell inner membrane</keyword>
    <keyword id="KW-1003">Cell membrane</keyword>
    <keyword id="KW-0406">Ion transport</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0630">Potassium</keyword>
    <keyword id="KW-0633">Potassium transport</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000279787" description="Probable potassium transport system protein kup 2">
        <location>
            <begin position="1"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_01522"/>
        </source>
    </evidence>
    <sequence length="606" mass="66611" checksum="E0F9C672FADA6762" modified="2005-11-22" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2021-09-29" version="55" xmlns="http://uniprot.org/uniprot">
    <accession>Q39WT5</accession>
    <name>Q39WT5_GEOMG</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ordered locus">Gmet_1049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="1 2" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513223.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_1049"/>
    <dbReference type="EnsemblBacteria" id="ABB31289">
        <property type="protein sequence ID" value="ABB31289"/>
        <property type="gene ID" value="Gmet_1049"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_1049"/>
    <dbReference type="eggNOG" id="ENOG50330WW">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_078787_0_0_7"/>
    <dbReference type="OMA" id="ERCDIFE"/>
    <dbReference type="OrthoDB" id="827979at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="ABB31289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="316" mass="35491" checksum="686096CB664E7BA1" modified="2005-11-22" version="1">MTSLHEDFWYRTLFKLRLYEASGNAFQRLFSEVMQQALPGFQAVAPWGNWGDGGNDGWCPPENRYFQVYGPEATTEVNVVQAATKAVGDFAKLRKKWPGVERYHFVCNDRYCGMPAPIGSMLLDLAKQEKLLEATPFSSADLTARFISLKDSQKVAIVYGIPSELPDFIDPHAVSELLTGLADGDNTHPSLLDGVSPDFDAKIKLNGIKSPVSESLSYYFYQVADVDRFLNARDIGLAQKIAFEIKALYHDSKKVIPNSADAPNERYVWLIDRLIPTSLPRHPHSMKAYRQAAQVIIAKYFETCDAYEHPNSFNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-11-22" modified="2022-08-03" version="118" xmlns="http://uniprot.org/uniprot">
    <accession>Q39XK3</accession>
    <name>Q39XK3_GEOMG</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ordered locus">Gmet_0779</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Geobacter metallireducens (strain ATCC 53774 / DSM 7210 / GS-15)</name>
        <dbReference type="NCBI Taxonomy" id="269799"/>
        <lineage>
            <taxon>Bacteria</taxon>
            <taxon>Proteobacteria</taxon>
            <taxon>Deltaproteobacteria</taxon>
            <taxon>Desulfuromonadales</taxon>
            <taxon>Geobacteraceae</taxon>
            <taxon>Geobacter</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="submission" date="2005-10" db="EMBL/GenBank/DDBJ databases">
            <title>Complete sequence of Geobacter metallireducens GS-15.</title>
            <authorList>
                <consortium name="US DOE Joint Genome Institute"/>
                <person name="Copeland A."/>
                <person name="Lucas S."/>
                <person name="Lapidus A."/>
                <person name="Barry K."/>
                <person name="Detter J.C."/>
                <person name="Glavina T."/>
                <person name="Hammon N."/>
                <person name="Israni S."/>
                <person name="Pitluck S."/>
                <person name="Di Bartolo G."/>
                <person name="Chain P."/>
                <person name="Schmutz J."/>
                <person name="Larimer F."/>
                <person name="Land M."/>
                <person name="Kyrpides N."/>
                <person name="Ivanova N."/>
                <person name="Richardson P."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <reference evidence="6 7" key="2">
        <citation type="journal article" date="2009" name="BMC Microbiol." volume="9" first="109" last="109">
            <title>The genome sequence of Geobacter metallireducens: features of metabolism, physiology and regulation common and dissimilar to Geobacter sulfurreducens.</title>
            <authorList>
                <person name="Aklujkar M."/>
                <person name="Krushkal J."/>
                <person name="DiBartolo G."/>
                <person name="Lapidus A."/>
                <person name="Land M.L."/>
                <person name="Lovley D.R."/>
            </authorList>
            <dbReference type="PubMed" id="19473543"/>
            <dbReference type="DOI" id="10.1186/1471-2180-9-109"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">ATCC 53774 / DSM 7210 / GS-15</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="CP000148">
        <property type="protein sequence ID" value="ABB31021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="WP_004513524.1">
        <property type="nucleotide sequence ID" value="NC_007517.1"/>
    </dbReference>
    <dbReference type="STRING" id="269799.Gmet_0779"/>
    <dbReference type="EnsemblBacteria" id="ABB31021">
        <property type="protein sequence ID" value="ABB31021"/>
        <property type="gene ID" value="Gmet_0779"/>
    </dbReference>
    <dbReference type="KEGG" id="gme:Gmet_0779"/>
    <dbReference type="eggNOG" id="COG4191">
        <property type="taxonomic scope" value="Bacteria"/>
    </dbReference>
    <dbReference type="HOGENOM" id="CLU_000445_133_3_7"/>
    <dbReference type="OMA" id="INSARFK"/>
    <dbReference type="OrthoDB" id="1755994at2"/>
    <dbReference type="Proteomes" id="UP000007073">
        <property type="component" value="Chromosome"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="SSF47384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="SSF55785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="SSF55874"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="227"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="23"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="159"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="ABB31021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000007073"/>
        </source>
    </evidence>
    <sequence length="434" mass="49193" checksum="0F69A0F9FBF9E611" modified="2005-11-22" version="1">MELPLQSVVPRTEGDALTLLHELQVHQIELEMQNEELHRSQDELRSSRDRYSLLYDFAPVGYFTLSRNGTILSANLAGATLLNTERSRLIRQNFGRFLDKINSARFKELLDKVFSGNNTHTFELLMSKGLQQPLFVQIEGTTVVPGDECLMAVIDITPRKQAEDNLLRAREELEQRVLERTVELARSIDREKEEMTGRLQAVEELRNKELLLVHQGRMAAMGEMLANIAHQWRQSLNVMGLLIQQLGLFSESDCLDKQLVSVNVAKAMEILKHLSQTIDDFRAFSEPDREKIPFRINQVIKKTLELVGELFTQQGISIQSDFVQDSQVAGFPNEFSQALLNLLLNARDALVADKWIKVSSRPENGRAVVTITDNGGGIDENIIDKVFDPYFTTKKLGKGSGIGLFMSKNIIERNMGGHLTVRNIKECAEFRIEV</sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>